Literatures

Primary Site >> Stomach Cancer

Gene >> TIMP2

1.
Journal:	Clin Chim Acta. 1993 Oct 29;220(1):31-45.
Title:	A one-step sandwich enzyme immunoassay for tissue inhibitor of metalloproteinases-2 using monoclonal antibodies.
Author:	Fujimoto, N\|Zhang, J\|Iwata, K\|Shinya, T\|Okada, Y\|Hayakawa, T
PMID:	8287559

2.
Journal:	Clin Chim Acta. 1993 Nov 30;221(1-2):91-103.
Title:	A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 2 (72-kDa gelatinase/type IV collagenase) using monoclonal antibodies.
Author:	Fujimoto, N\|Mouri, N\|Iwata, K\|Ohuchi, E\|Okada, Y\|Hayakawa, T
PMID:	8149645

3.
Journal:	Mod Pathol. 1994 Feb;7(2):220-5.
Title:	Prognosis of gastric carcinoma revealed by interactions between tumor cells and basement membrane.
Author:	Grigioni, W F\|D'Errico, A\|Fortunato, C\|Fiorentino, M\|Mancini, A M\|Stetler-Stevenson, W G\|Sobel, M E\|Liotta, L A\|Onisto, M\|Garbisa, S
PMID:	8008747

4.
Journal:	Int J Cancer. 1996 Feb 20;69(1):9-16.
Title:	Enhanced production of matrix metalloproteinases and activation of matrix metalloproteinase 2 (gelatinase A) in human gastric carcinomas.
Author:	Nomura, H\|Fujimoto, N\|Seiki, M\|Mai, M\|Okada, Y
PMID:	8600068

5.
Journal:	Semin Oncol. 1996 Jun;23(3):316-24.
Title:	Invasion and metastases in gastric cancer: in vitro and in vivo models with clinical correlations.
Author:	Schwartz, G K
PMID:	8658215

6.
Journal:	J Korean Med Sci. 1996 Dec;11(6):474-9.
Title:	Overexpression of tissue inhibitors of metalloproteinase-1 and -2 in the stroma of gastric cancer.
Author:	Hong, S I\|Park, I C\|Hong, W S\|Son, Y S\|Lee, S H\|Lee, J I\|Choi, D W\|Moon, N M\|Choe, T B\|Jang, J J
PMID:	9008095

7.
Journal:	Br J Surg. 1997 Dec;84(12):1651-64.
Title:	Prognostic factors in gastric cancer.
Author:	Allgayer, H\|Heiss, M M\|Schildberg, F W
PMID:	9448610

8.
Journal:	J Korean Med Sci. 1998 Jun;13(3):286-90.
Title:	Reduced expression of tissue inhibitor of metalloproteinase in nodal metastasis of stomach cancer.
Author:	Ko, B K\|Cho, H R\|Choi, D W\|Nam, C W\|Park, C J\|Kim, G Y\|Kim, S S\|Woo, Y J\|Huh, J\|Kim, M Y
PMID:	9681807

9.
Journal:	Gut. 1998 Dec;43(6):791-7.
Title:	Matrix metalloproteinases and their inhibitors in gastric cancer.
Author:	Murray, G I\|Duncan, M E\|Arbuckle, E\|Melvin, W T\|Fothergill, J E
PMID:	9824606

10.
Journal:	Zhonghua Bing Li Xue Za Zhi. 1998 Oct;27(5):362-5.
Title:	[The effect of tissue inhibitor of metalloproteinase-2 gene (TIMP-2 gene) on gastric carcinoma cells in vitro and in vivo].
Author:	Li, N\|Xu, C\|Liu, W
PMID:	11245013

11.
Journal:	J Cancer Res Clin Oncol. 1999 Oct;125(10):541-8.
Title:	Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma.
Author:	Sakamoto, A\|Oda, Y\|Iwamoto, Y\|Tsuneyoshi, M
PMID:	10473866

12.
Journal:	Dig Dis Sci. 2000 Jan;45(1):114-21.
Title:	Expression of tissue inhibitors of metalloproteinases (TIMPs) in gastric cancer.
Author:	Joo, Y E\|Seo, K S\|Kim, H S\|Rew, J S\|Park, C S\|Kim, S J
PMID:	10695623

13.
Journal:	Int J Oncol. 2001 Feb;18(2):355-61.
Title:	Comparative study of angiostatic and anti-invasive gene expressions as prognostic factors in gastric cancer.
Author:	Lee, J H\|Koh, J T\|Shin, B A\|Ahn, K Y\|Roh, J H\|Kim, Y J\|Kim, K K
PMID:	11172604

14.
Journal:	Hum Pathol. 2002 Jan;33(1):80-6.
Title:	Relationship between biologic behavior and phenotypic expression in intramucosal gastric carcinomas.
Author:	Kabashima, Akira\|Yao, Takashi\|Sugimachi, Keizo\|Tsuneyoshi, Masazumi
PMID:	11823976

15.
Journal:	Wei Sheng Yan Jiu. 2003 Mar;32(2):117-9.
Title:	[Effects of c9, t11-conjugated linoleic acid on the metastasis of human gastric carcinoma cell line].
Author:	Yang, Yanmei\|Chen, Bingqing\|Xue, Yingben\|Zheng, Yumei
PMID:	12792999

16.
Journal:	World J Gastroenterol. 2003 Sep;9(9):1909-14.
Title:	Inhibitory effects of c9, t11-conjugated linoleic acid on invasion of human gastric carcinoma cell line SGC-7901.
Author:	Chen, Bing-Qing\|Yang, Yan-Mei\|Gao, Yan-Hui\|Liu, Jia-Ren\|Xue, Ying-Ben\|Wang, Xuan-Lin\|Zheng, Yu-Mei\|Zhang, Jing-Shu\|Liu, Rui-Hai
PMID:	12970874

17.
Journal:	Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Jan;37(1):26-8.
Title:	[The effects of conjugated linoleic acid on the expression of invasiveness and metastasis-associated gene of human gastric carcinoma cell line].
Author:	Yang, Yan-mei\|Chen, Bing-qing\|Zheng, Yu-mei\|Wang, Xuan-lin\|Liu, Jia-ren\|Xue, Ying-ben\|Liu, Rui-hai
PMID:	12760791

18.
Journal:	Dig Dis Sci. 2004 Oct;49(10):1621-30.
Title:	Enhanced cell surface expression of matrix metalloproteinases and their inhibitors, and tumor-induced host response in progression of human gastric carcinoma.
Author:	Koyama, Shohei
PMID:	15573916

19.
Journal:	Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Dec;29(6):643-6.
Title:	[Helicobacter pylori infection, the invasion and metastasis of the gastric carcinoma, and the expression of MMP-2 and TIMP-2].
Author:	Xu, Can-xia\|Zhong, Hua\|Shen, Shou-rong
PMID:	16114547

20.
Journal:	J Cancer Res Clin Oncol. 2005 Dec;131(12):809-14.
Title:	Coordinate cell-surface expression of matrix metalloproteinases and their inhibitors on cancer-associated myofibroblasts from malignant ascites in patients with gastric carcinoma.
Author:	Koyama, Shohei
PMID:	16180025

21.
Journal:	World J Gastroenterol. 2005 Sep 28;11(36):5592-600.
Title:	DNA ploidy analysis and expression of MMP-9, TIMP-2, and E-cadherin in gastric carcinoma.
Author:	Zhang, Jing-Fang\|Zhang, Yuan-Ping\|Hao, Feng-Yun\|Zhang, Cai-Xin\|Li, Yu-Jun\|Ji, Xiang-Rui
PMID:	16237750

22.
Journal:	Br J Cancer. 2006 Sep 18;95(6):744-51. Epub 2006 Aug 29.
Title:	Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer.
Author:	Kubben, F J G M\|Sier, C F M\|Meijer, M J W\|van den Berg, M\|van der Reijden, J J\|Griffioen, G\|van de Velde, C J H\|Lamers, C B H W\|Verspaget, H W
PMID:	16940985

23.
Journal:	Eur J Cancer. 2007 Mar;43(4):799-808. Epub 2007 Jan 22.
Title:	Clinicopathological significance of MMP-2 and TIMP-2 genotypes in gastric cancer.
Author:	Wu, Chun-Ying\|Wu, Ming-Shiang\|Chen, Yi-Ju\|Chen, Chien-Jen\|Chen, Hsiao-Ping\|Shun, Chia-Tung\|Chen, Gran-Hum\|Huang, Shih-Pei\|Lin, Jaw-Town
PMID:	17236757

24.
Journal:	Eur J Cancer. 2007 Aug;43(12):1869-76. Epub 2007 Jul 2.
Title:	Clinical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer.
Author:	Kubben, Frank J G M\|Sier, Cornelis F M\|Hawinkels, Lukas J A C\|Tschesche, Harald\|van Duijn, Wim\|Zuidwijk, Kim\|van der Reijden, Johan J\|Hanemaaijer, Roeland\|Griffioen, Gerrit\|Lamers, Cornelis B H W\|Verspaget, Hein W
PMID:	17604154

25.
Journal:	Eur J Surg Oncol. 2008 Jun;34(6):636-41. Epub 2007 Oct 22.
Title:	Tissue inhibitor of metalloproteinase-2 G-418C polymorphism is associated with an increased risk of gastric cancer in a Chinese population.
Author:	Yang, L\|Gu, H-J\|Zhu, H-J\|Sun, Q-M\|Cong, R-H\|Zhou, B\|Tang, N-P\|Wang, B
PMID:	17954022

26.
Journal:	Histol Histopathol. 2008 Aug;23(8):917-23.
Title:	Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer.
Author:	Alakus, H\|Grass, G\|Hennecken, J K\|Bollschweiler, E\|Schulte, C\|Drebber, U\|Baldus, S E\|Metzger, R\|Holscher, A H\|Monig, S P
PMID:	18498066

27.
Journal:	Bull Exp Biol Med. 2009 Dec;148(6):899-902.
Title:	Comparative enzyme immunoassay of matrix metalloproteinases-2, -7, -9 and their tissue inhibitor-2 in tumors and plasma of patients with gastric cancer.
Author:	Gerstein, E S\|Sini, Li\|Ryabov, A B\|Dvorova, E K\|Yurchenko, A A\|Stilidi, I S\|Kushlinskii, N E\|Davydov, M I
PMID:	21116502

28.
Journal:	World J Surg. 2010 Dec;34(12):2853-9.
Title:	Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer.
Author:	Alakus, Hakan\|Afriani, Noor\|Warnecke-Eberz, Ute\|Bollschweiler, Elfriede\|Fetzner, Ulrich\|Drebber, Uta\|Metzger, Ralf\|Holscher, Arnulf H\|Monig, Stefan P
PMID:	20730428

29.
Journal:	Life Sci. 2010 Jun 19;86(25-26):936-41.
Title:	Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG.
Author:	Manikandan, Palrasu\|Murugan, Ramalingam Senthil\|Priyadarsini, Ramamurthi Vidya\|Vinothini, Govindarajah\|Nagini, Siddavaram
PMID:	20434464

30.
Journal:	Cancer Sci. 2010 Nov;101(11):2398-403.
Title:	Exogenous introduction of tissue inhibitor of metalloproteinase 2 reduces accelerated growth of TGF-beta-disrupted diffuse-type gastric carcinoma.
Author:	Johansson, Erik\|Komuro, Akiyoshi\|Iwata, Caname\|Hagiwara, Akifumi\|Fuse, Yuma\|Watanabe, Akira\|Morishita, Yasuyuki\|Aburatani, Hiroyuki\|Funa, Keiko\|Kano, Mitsunobu R\|Miyazono, Kohei
PMID:	20718757

31.
Journal:	Mol Biol Rep. 2011 Mar;38(3):1541-50.
Title:	Regulation of MMP-2 expression and activity by beta-1,3-N-acetylglucosaminyltransferase-8 in AGS gastric cancer cells.
Author:	Shen, Li\|Liu, Zhenhua\|Tu, Youbin\|Xu, Lan\|Sun, Xiaoya\|Wu, Shiliang
PMID:	20963502

32.
Journal:	Acta Pharmacol Sin. 2011 Feb;32(2):259-69.
Title:	Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells.
Author:	Wu, Xue-mei\|Shao, Xiang-qiang\|Meng, Xian-xin\|Zhang, Xiao-na\|Zhu, Li\|Liu, Shi-xu\|Lin, Jian\|Xiao, Hua-sheng
PMID:	21293479

33.
Journal:	J Surg Oncol. 2011 Mar 1;103(3):243-7.
Title:	Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric adenocarcinoma.
Author:	Zhang, Ming\|Zhu, Guan-Yu\|Gao, Hong-Yu\|Zhao, Shu-Peng\|Xue, Yingwei
PMID:	21337552

34.
Journal:	Folia Histochem Cytobiol. 2011;49(1):125-31.
Title:	Clinical significance of serum levels of matrix metalloproteinase 2 (MMP-2) and its tissue inhibitor (TIMP-2) in gastric cancer.
Author:	Mroczko, Barbara\|Lukaszewicz-Zajac, Marta\|Gryko, Mariusz\|Kedra, Boguslaw\|Szmitkowski, Maciej
PMID:	21526499

35.
Journal:	Cancer Res. 2011 Dec 1;71(23):7187-97.
Title:	Classification of Epstein-Barr virus-positive gastric cancers by definition of DNA methylation epigenotypes.
Author:	Matsusaka, Keisuke\|Kaneda, Atsushi\|Nagae, Genta\|Ushiku, Tetsuo\|Kikuchi, Yasuko\|Hino, Rumi\|Uozaki, Hiroshi\|Seto, Yasuyuki\|Takada, Kenzo\|Aburatani, Hiroyuki\|Fukayama, Masashi
PMID:	21990320

36.
Journal:	Zhonghua Yu Fang Yi Xue Za Zhi. 2011 Aug;45(8):711-6.
Title:	[Association of polymorphism in matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 with genetic susceptibility of gastric cancer].
Author:	Lin, Xian-dong\|Chen, Gang\|Li, Chao\|Zhang, Li-yuan\|Shi, Yi\|Zhou, Dong-mei\|Zheng, Xiong-wei
PMID:	22169692

37.
Journal:	J Med Food. 2012 Jan;15(1):24-32.
Title:	The hexane extract of Saussurea lappa and its active principle, dehydrocostus lactone, inhibit prostate cancer cell migration.
Author:	Kim, Eun Ji\|Hong, Ji Eun\|Lim, Soon Sung\|Kwon, Gyoo Taik\|Kim, Jongdai\|Kim, Jong-Sang\|Lee, Ki Won\|Park, Jung Han Yoon
PMID:	22082097

38.
Journal:	Oncol Lett. 2013 Feb;5(2):574-582.
Title:	Expression of C-X-C chemokine receptor types 1/2 in patients with gastric carcinoma: Clinicopathological correlations and significance.
Author:	Wang, Jun Pu\|Hu, Wan Ming\|Wang, Kuan Song\|Yu, Jun\|Luo, Bai Hua\|Wu, Chang\|Chen, Zhi Hong\|Luo, Geng Qiu\|Liu, Yu Wu\|Liu, Qin Lai\|Xiao, Yan\|Zhou, Hai Yan\|Yang, Xiao Jing\|Jiang, Hai Ying\|Li, Jing He\|Wen, Ji Fang
PMID:	23420470

39.
Journal:	Adv Med Sci. 2013;58(2):235-43.
Title:	Matrix metalloproteinase 2 (MMP-2) and their tissue inhibitor 2 (TIMP-2) in gastric cancer patients.
Author:	Lukaszewicz-Zajac, M\|Mroczko, B\|Guzinska-Ustymowicz, K\|Pryczynicz, A\|Gryko, M\|Kemona, A\|Kedra, B\|Szmitkowski, M
PMID:	24384769

40.
Journal:	Tumour Biol. 2014 Feb;35(2):1481-8.
Title:	Inhibition of gastric cancer cell growth and invasion through siRNA-mediated knockdown of guanine nucleotide exchange factor Vav3.
Author:	Tan, Bibo\|Li, Yong\|Zhao, Qun\|Fan, Liqiao\|Wang, Dong\|Liu, Yu
PMID:	24072493

41.
Journal:	FEBS Lett. 2014 Feb 14;588(4):600-7.
Title:	MicroRNA-106a targets TIMP2 to regulate invasion and metastasis of gastric cancer.
Author:	Zhu, Meng\|Zhang, Ning\|He, Shuixiang\|Lui, Yuanyuan\|Lu, Guifang\|Zhao, Lin
PMID:	24440352

42.
Journal:	Neoplasma. 2014;61(3):257-64.
Title:	Impact of Annexin A3 expression in gastric cancer cells.
Author:	Yu, S Y\|Li, Y\|Fan, L Q\|Zhao, Q\|Tan, B B\|Liu, Y
PMID:	24824926

43.
Journal:	PLoS One. 2014 Jun 6;9(6):e96678.
Title:	Interleukin 17A promotes gastric cancer invasiveness via NF-kappaB mediated matrix metalloproteinases 2 and 9 expression.
Author:	Wang, Yidong\|Wu, Hong\|Wu, Xiaoling\|Bian, Zhuoqiong\|Gao, Qing
PMID:	24905806

44.
Journal:	Pathol Oncol Res. 2015 Jan;21(1):73-81.
Title:	Immunoexpression of metalloproteinases 2 and 14 and TIMP-2 inhibitor in main types of primary gastric carcinomas and lymph node metastasis.
Author:	Gurgel, Daniel Cordeiro\|Valenca-Junior, Jose Telmo\|Dornelas, Conceicao Aparecida\|Vieira, Renato Braga\|Maia-Filho, Joao Tarcisio Alves\|Lima-Junior, Roberto Cesar Pereira\|Ribeiro, Ronaldo Albuquerque\|Almeida, Paulo Roberto Carvalho
PMID:	24800696

45.
Journal:	Int J Clin Exp Med. 2015 Nov 15;8(11):20391-401. eCollection 2015.
Title:	Correlations of MMP-2 and TIMP-2 gene polymorphisms with the risk and prognosis of gastric cancer.
Author:	Zhang, De-Yong\|Wang, Jing\|Zhang, Guan-Qi\|Chu, Xian-Qun\|Zhang, Jian-Liang\|Zhou, Yong
PMID:	26884955

46.
Journal:	Oncol Lett. 2015 Apr;9(4):1772-1778.
Title:	Cancer and embryo expression protein 65 promotes cancer cell growth and metastasis.
Author:	Jin, Genglin\|Peng, Lirong\|Zhang, Jianzhi\|Qu, Like\|Shou, Chengchao
PMID:	25789040

47.
Journal:	Am J Dermatopathol. 2015 May;37(5):381-8.
Title:	Comparative expression of matrix metalloproteinases in internal malignancies and paired cutaneous metastatic lesions.
Author:	Kim, Tae Hyung\|Jung, Jin Young\|Roh, Hyo Jin\|Chung, Kee Yang\|Roh, Mi Ryung
PMID:	25062266

48.
Journal:	Clin Exp Metastasis. 2016 Jun;33(5):509-19.
Title:	MicroRNA-106a functions as an oncogene in human gastric cancer and contributes to proliferation and metastasis in vitro and in vivo.
Author:	Zhu, Meng\|Zhang, Ning\|He, Shuixiang\|Yan, Ruirui\|Zhang, Jun
PMID:	27142596

49.
Journal:	Asian Pac J Trop Med. 2016 Aug;9(8):796-800.
Title:	Effect of hGC-MSCs from human gastric cancer tissue on cell proliferation, invasion and epithelial-mesenchymal transition in tumor tissue of gastric cancer tumor-bearing mice.
Author:	Song, Lin\|Zhou, Xin\|Jia, Hong-Jun\|Du, Mei\|Zhang, Jin-Ling\|Li, Liang
PMID:	27569891

50.
Journal:	Onco Targets Ther. 2016 Nov 3;9:6801-6808.
Title:	Association of TIMP-2-418G/C and TIMP-2-303G/A with gastric cancer: a meta-analysis.
Author:	Yang, Yan\|Xiong, Yuqi\|Li, Jing\|Wu, Changping\|Jiang, Jingting
PMID:	27843330

51.
Journal:	Pathol Res Pract. 2017 May;213(5):435-440.
Title:	Expression of Vav3 protein and its prognostic value in patients with gastric cancer.
Author:	Tan, Bibo\|Li, Yong\|Shi, Xiaoming\|Fan, Liqiao\|Zhao, Qun\|Liu, Yanli\|Tan, Ming\|Liu, Qingwei\|Jia, Nan
PMID:	28285969

52.
Journal:	Oncol Lett. 2017 Feb;13(2):655-660.
Title:	Anti-metastatic activity of fangchinoline in human gastric cancer AGS cells.
Author:	Chen, Zhengrong\|He, Tengfei\|Zhao, Kui\|Xing, Chungen
PMID:	28356942

53.
Journal:	Clin Epigenetics. 2017 Oct 17;9:114.
Title:	MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer.
Author:	Sandoval-Borquez, Alejandra\|Polakovicova, Iva\|Carrasco-Veliz, Nicolas\|Lobos-Gonzalez, Lorena\|Riquelme, Ismael\|Carrasco-Avino, Gonzalo\|Bizama, Carolina\|Norero, Enrique\|Owen, Gareth I\|Roa, Juan C\|Corvalan, Alejandro H
PMID:	29075357

54.
Journal:	PLoS One. 2017 Dec 8;12(12):e0189490.
Title:	MicroRNA-93 promotes proliferation and metastasis of gastric cancer via targeting TIMP2.
Author:	Guan, Hao\|Li, Weiming\|Li, Yuanyuan\|Wang, Jichang\|Li, Yan\|Tang, Yanan\|Lu, Shaoying
PMID:	29220395

55.
Journal:	World J Gastroenterol. 2017 Dec 28;23(48):8512-8525.
Title:	Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts.
Author:	Wang, Zhen-Fei\|Ma, Da-Guang\|Zhu, Zhe\|Mu, Yong-Ping\|Yang, Yong-Yan\|Feng, Li\|Yang, Hao\|Liang, Jun-Qing\|Liu, Yong-Yan\|Liu, Li\|Lu, Hai-Wen
PMID:	29358859

56.
Journal:	Med Sci Monit. 2018 Apr 24;24:2508-2517.
Title:	Overexpression of Myosin Phosphatase Target Subunit 1 (MYPT1) Inhibits Tumor Progression and Metastasis of Gastric Cancer.
Author:	Wang, Fengyong\|Sun, Yuanshui
PMID:	29687789

57.
Journal:	Sci Rep. 2018 Jun 25;8(1):9629.
Title:	TIMP2 is a Poor Prognostic Factor and Predicts Metastatic Biological Behavior in Gastric Cancer.
Author:	Wang, Wei\|Zhang, Yifan\|Liu, Mingxing\|Wang, Yang\|Yang, Tao\|Li, Dongsheng\|Ding, Feng\|Bai, Guang\|Li, Qing
PMID:	29941993

58.
Journal:	Biomed Pharmacother. 2018 Nov;107:397-407.
Title:	Rosmarinic acid influences collagen, MMPs, TIMPs, glycosylation and MUC1 in CRL-1739 gastric cancer cell line.
Author:	Radziejewska, I\|Supruniuk, K\|Nazaruk, J\|Karna, E\|Poplawska, B\|Bielawska, A\|Galicka, A
PMID:	30099344

59.
Journal:	J Cell Biochem. 2018 Aug 20.
Title:	Knockdown of long noncoding RNA urothelial carcinoma-associated 1 inhibits cell viability, migration, and invasion by regulating microRNA-182 in gastric carcinoma.
Author:	Qin, Lei\|Jia, Zhihua\|Xie, Dawei\|Liu, Zhongyuan
PMID:	30129054