Primary Site >> Pancreatic Cancer
Gene >> TGFBR1
| 1. | |||||||||||
| Journal: | Cancer Res. 1993 Jun 15;53(12):2704-7. | ||||||||||
| Title: | Enhanced expression of the type II transforming growth factor beta receptor in human pancreatic cancer cells without alteration of type III receptor expression. | ||||||||||
| Author: | Friess, H|Yamanaka, Y|Buchler, M|Berger, H G|Kobrin, M S|Baldwin, R L|Korc, M | ||||||||||
| PMID: | 8389240 | ||||||||||
| 2. | |||||||||||
| Journal: | Int J Cancer. 1996 Jul 17;67(2):283-8. | ||||||||||
| Title: | Attenuated ALK5 receptor expression in human pancreatic cancer: correlation with resistance to growth inhibition. | ||||||||||
| Author: | Baldwin, R L|Friess, H|Yokoyama, M|Lopez, M E|Kobrin, M S|Buchler, M W|Korc, M | ||||||||||
| PMID: | 8760600 | ||||||||||
| 3. | |||||||||||
| Journal: | Dig Dis Sci. 1997 Oct;42(10):2054-63. | ||||||||||
| Title: | Presence of two signaling TGF-beta receptors in human pancreatic cancer correlates with advanced tumor stage. | ||||||||||
| Author: | Lu, Z|Friess, H|Graber, H U|Guo, X|Schilling, M|Zimmermann, A|Korc, M|Buchler, M W | ||||||||||
| PMID: | 9365135 | ||||||||||
| 4. | |||||||||||
| Journal: | Int J Cancer. 1998 Oct 5;78(2):255-60. | ||||||||||
| Title: | Transfection of the type I TGF-beta receptor restores TGF-beta responsiveness in pancreatic cancer. | ||||||||||
| Author: | Wagner, M|Kleeff, J|Lopez, M E|Bockman, I|Massaque, J|Korc, M | ||||||||||
| PMID: | 9754660 | ||||||||||
| 5. | |||||||||||
| Journal: | Cancer Res. 1998 Dec 1;58(23):5329-32. | ||||||||||
| Title: | Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas. | ||||||||||
| Author: | Goggins, M|Shekher, M|Turnacioglu, K|Yeo, C J|Hruban, R H|Kern, S E | ||||||||||
| PMID: | 9850059 | ||||||||||
| 6. | |||||||||||
| Journal: | Biochem Biophys Res Commun. 1999 Feb 16;255(2):268-73. | ||||||||||
| Title: | Smad6 suppresses TGF-beta-induced growth inhibition in COLO-357 pancreatic cancer cells and is overexpressed in pancreatic cancer. | ||||||||||
| Author: | Kleeff, J|Maruyama, H|Friess, H|Buchler, M W|Falb, D|Korc, M | ||||||||||
| PMID: | 10049697 | ||||||||||
| 7. | |||||||||||
| Journal: | Ann Oncol. 1999;10 Suppl 4:4-8. | ||||||||||
| Title: | Progress in cancer genetics: lessons from pancreatic cancer. | ||||||||||
| Author: | Goggins, M|Kern, S E|Offerhaus, J A|Hruban, R H | ||||||||||
| PMID: | 10436774 | ||||||||||
| 8. | |||||||||||
| Journal: | Oncogene. 1999 Sep 23;18(39):5363-72. | ||||||||||
| Title: | The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer. | ||||||||||
| Author: | Kleeff, J|Ishiwata, T|Maruyama, H|Friess, H|Truong, P|Buchler, M W|Falb, D|Korc, M | ||||||||||
| PMID: | 10498890 | ||||||||||
| 9. | |||||||||||
| Journal: | Dig Dis Sci. 1999 Sep;44(9):1793-802. | ||||||||||
| Title: | Overexpression of Smad2 and colocalization with TGF-beta1 in human pancreatic cancer. | ||||||||||
| Author: | Kleeff, J|Friess, H|Simon, P|Susmallian, S|Buchler, P|Zimmermann, A|Buchler, M W|Korc, M | ||||||||||
| PMID: | 10505717 | ||||||||||
| 10. | |||||||||||
| Journal: | Pancreas. 1999 Nov;19(4):370-6. | ||||||||||
| Title: | Enhanced expression of the type II transforming growth factor-beta receptor is associated with decreased survival in human pancreatic cancer. | ||||||||||
| Author: | Wagner, M|Kleeff, J|Friess, H|Buchler, M W|Korc, M | ||||||||||
| PMID: | 10547197 | ||||||||||
| 11. | |||||||||||
| Journal: | Curr Opin Gastroenterol. 2000 Sep;16(5):419-25. | ||||||||||
| Title: | Molecular genetics of ductal pancreatic neoplasia. | ||||||||||
| Author: | Su, G H|Kern, S E | ||||||||||
| PMID: | 17031113 | ||||||||||
| 12. | |||||||||||
| Journal: | Int J Oncol. 2001 Jul;19(1):71-81. | ||||||||||
| Title: | Altered expression of TGFB receptors and mitogenic effects of TGFB in pancreatic carcinomas. | ||||||||||
| Author: | Jonson, T|Albrechtsson, E|Axelson, J|Heidenblad, M|Gorunova, L|Johansson, B|Hoglund, M | ||||||||||
| PMID: | 11408925 | ||||||||||
| 13. | |||||||||||
| Journal: | Hepatogastroenterology. 2001 Jul-Aug;48(40):933-8. | ||||||||||
| Title: | Molecular diagnosis of pancreatic cancer. | ||||||||||
| Author: | Inoue, S|Tezel, E|Nakao, A | ||||||||||
| PMID: | 11490843 | ||||||||||
| 14. | |||||||||||
| Journal: | Clin Cancer Res. 2001 Sep;7(9):2931-40. | ||||||||||
| Title: | Soluble type II transforming growth factor-beta (TGF-beta) receptor inhibits TGF-beta signaling in COLO-357 pancreatic cancer cells in vitro and attenuates tumor formation. | ||||||||||
| Author: | Rowland-Goldsmith, M A|Maruyama, H|Kusama, T|Ralli, S|Korc, M | ||||||||||
| PMID: | 11555612 | ||||||||||
| 15. | |||||||||||
| Journal: | Oncogene. 2003 Jun 12;22(24):3698-711. | ||||||||||
| Title: | Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest. | ||||||||||
| Author: | Nicolas, Francisco J|Hill, Caroline S | ||||||||||
| PMID: | 12802277 | ||||||||||
| 16. | |||||||||||
| Journal: | Cancer Res. 2004 Aug 1;64(15):5200-11. | ||||||||||
| Title: | Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1. | ||||||||||
| Author: | Subramanian, Gayathri|Schwarz, Roderich E|Higgins, Linda|McEnroe, Glenn|Chakravarty, Sarvajit|Dugar, Sundeep|Reiss, Michael | ||||||||||
| PMID: | 15289325 | ||||||||||
| 17. | |||||||||||
| Journal: | J Biol Chem. 2005 Jun 10;280(23):21858-66. Epub 2005 Apr 4. | ||||||||||
| Title: | Smad7 abrogates transforming growth factor-beta1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein. | ||||||||||
| Author: | Boyer Arnold, Nichole|Korc, Murray | ||||||||||
| PMID: | 15811853 | ||||||||||
| 18. | |||||||||||
| Journal: | Int J Cancer. 2007 Apr 15;120(8):1641-51. | ||||||||||
| Title: | Antitumor activity of ALK1 in pancreatic carcinoma cells. | ||||||||||
| Author: | Ungefroren, Hendrik|Schniewind, Bodo|Groth, Stephanie|Chen, Wen-Bin|Muerkoster, Susanne Sebens|Kalthoff, Holger|Fandrich, Fred | ||||||||||
| PMID: | 17230504 | ||||||||||
| 19. | |||||||||||
| Journal: | Oncogene. 2007 Jul 19;26(33):4850-62. Epub 2007 Feb 12. | ||||||||||
| Title: | Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function. | ||||||||||
| Author: | Schniewind, B|Groth, S|Sebens Muerkoster, S|Sipos, B|Schafer, H|Kalthoff, H|Fandrich, F|Ungefroren, H | ||||||||||
| PMID: | 17297450 | ||||||||||
| 20. | |||||||||||
| Journal: | Cancer Res. 2007 Sep 1;67(17):8344-50. | ||||||||||
| Title: | Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer. | ||||||||||
| Author: | Hinz, Sebastian|Pagerols-Raluy, Laia|Oberg, Hans-Heinrich|Ammerpohl, Ole|Grussel, Sandra|Sipos, Bence|Grutzmann, Robert|Pilarsky, Christian|Ungefroren, Hendrik|Saeger, Hans-Detlev|Kloppel, Gunter|Kabelitz, Dieter|Kalthoff, Holger | ||||||||||
| PMID: | 17804750 | ||||||||||
| 21. | |||||||||||
| Journal: | Anticancer Res. 2007 Nov-Dec;27(6B):4149-57. | ||||||||||
| Title: | Antitumor activity of TGF-beta inhibitor is dependent on the microenvironment. | ||||||||||
| Author: | Medicherla, Satyanarayana|Li, Lingyun|Ma, Jing Ying|Kapoun, Ann M|Gaspar, Nicholas J|Liu, Yu-Wang|Mangadu, Ruban|O'Young, Gilbert|Protter, Andrew A|Schreiner, George F|Wong, Darren H|Higgins, Linda S | ||||||||||
| PMID: | 18229422 | ||||||||||
| 22. | |||||||||||
| Journal: | Growth Factors. 2009 Oct;27(5):289-99. | ||||||||||
| Title: | Transforming growth factor-beta induces nerve growth factor expression in pancreatic stellate cells by activation of the ALK-5 pathway. | ||||||||||
| Author: | Haas, Stephan L|Fitzner, Brit|Jaster, Robert|Wiercinska, Eliza|Gaitantzi, Haristi|Jesnowski, Ralf|Lohr, J-Matthias|Singer, Manfred V|Dooley, Steven|Breitkopf, Katja | ||||||||||
| PMID: | 19639490 | ||||||||||
| 23. | |||||||||||
| Journal: | Cancer Res. 2009 Dec 15;69(24):9169-74. | ||||||||||
| Title: | Tgfbr1 haploinsufficiency inhibits the development of murine mutant Kras-induced pancreatic precancer. | ||||||||||
| Author: | Adrian, Kevin|Strouch, Matthew J|Zeng, Qinghua|Barron, Morgan R|Cheon, Eric C|Honasoge, Akilesh|Xu, Yanfei|Phukan, Sharbani|Sadim, Maureen|Bentrem, David J|Pasche, Boris|Grippo, Paul J | ||||||||||
| PMID: | 19951995 | ||||||||||
| 24. | |||||||||||
| Journal: | Pancreas. 2013 Apr;42(3):411-21. | ||||||||||
| Title: | Molecular markers for novel therapeutic strategies in pancreatic endocrine tumors. | ||||||||||
| Author: | Gilbert, Judith A|Adhikari, Laura J|Lloyd, Ricardo V|Halfdanarson, Thorvardur R|Muders, Michael H|Ames, Matthew M | ||||||||||
| PMID: | 23211371 | ||||||||||
| 25. | |||||||||||
| Journal: | Int J Biol Markers. 2015 May 26;30(2):e226-33. | ||||||||||
| Title: | Identification of biomarkers for the prognosis of pancreatic ductal adenocarcinoma with miRNA microarray data. | ||||||||||
| Author: | Wang, Song|Zhao, Yanxun|Li, Dongsheng|Zhu, Liangchen|Shen, Zugang | ||||||||||
| PMID: | 25791160 | ||||||||||
| 26. | |||||||||||
| Journal: | Mol Med Rep. 2016 May;13(5):3913-9. | ||||||||||
| Title: | Gene expression profile analysis of pancreatic cancer based on microarray data. | ||||||||||
| Author: | Long, Jin|Liu, Zhe|Wu, Xingda|Xu, Yuanhong|Ge, Chunlin | ||||||||||
| PMID: | 27035876 | ||||||||||
| 27. | |||||||||||
| Journal: | Cell Signal. 2016 Nov;28(11):1652-62. | ||||||||||
| Title: | Negative control of TRAIL-R1 signaling by transforming growth factor beta1 in pancreatic tumor cells involves Smad-dependent down regulation of TRAIL-R1. | ||||||||||
| Author: | Radke, David I|Ungefroren, Hendrik|Helm, Ole|Voigt, Susann|Alp, Gokhan|Braun, Hendrik|Hubner, Sebastian|Dilchert, Janine|Sebens, Susanne|Adam, Dieter|Kalthoff, Holger|Trauzold, Anna | ||||||||||
| PMID: | 27492861 | ||||||||||
| 28. | |||||||||||
| Journal: | J Clin Med. 2016 Nov 30;5(12). pii: jcm5120111. | ||||||||||
| Title: | Proteinase-Activated Receptor 2 Is a Novel Regulator of TGF-beta Signaling in Pancreatic Cancer. | ||||||||||
| Author: | Witte, David|Zeeh, Franziska|Gadeken, Thomas|Gieseler, Frank|Rauch, Bernhard H|Settmacher, Utz|Kaufmann, Roland|Lehnert, Hendrik|Ungefroren, Hendrik | ||||||||||
| PMID: | 27916875 | ||||||||||
| 29. | |||||||||||
| Journal: | Mol Cancer Res. 2017 Aug;15(8):1029-1039. | ||||||||||
| Title: | miR-202 Diminishes TGFbeta Receptors and Attenuates TGFbeta1-Induced EMT in Pancreatic Cancer. | ||||||||||
| Author: | Mody, Hardik R|Hung, Sau Wai|Pathak, Rakesh K|Griffin, Jazmine|Cruz-Monserrate, Zobeida|Govindarajan, Rajgopal | ||||||||||
| PMID: | 28373289 | ||||||||||
| 30. | |||||||||||
| Journal: | Sci Rep. 2017 Dec 11;7(1):17313. | ||||||||||
| Title: | Negative regulation of TGF-beta1-induced MKK6-p38 and MEK-ERK signalling and epithelial-mesenchymal transition by Rac1b. | ||||||||||
| Author: | Witte, David|Otterbein, Hannah|Forster, Maria|Giehl, Klaudia|Zeiser, Robert|Lehnert, Hendrik|Ungefroren, Hendrik | ||||||||||
| PMID: | 29229918 | ||||||||||
| 31. | |||||||||||
| Journal: | Int J Mol Sci. 2017 Dec 20;18(12). pii: ijms18122776. | ||||||||||
| Title: | The Role of PAR2 in TGF-beta1-Induced ERK Activation and Cell Motility. | ||||||||||
| Author: | Ungefroren, Hendrik|Witte, David|Fiedler, Christian|Gadeken, Thomas|Kaufmann, Roland|Lehnert, Hendrik|Gieseler, Frank|Rauch, Bernhard H | ||||||||||
| PMID: | 29261154 | ||||||||||
| 32. | |||||||||||
| Journal: | Cell Death Dis. 2018 Jun 13;9(6):706. | ||||||||||
| Title: | Linc00462 promotes pancreatic cancer invasiveness through the miR-665/TGFBR1-TGFBR2/SMAD2/3 pathway. | ||||||||||
| Author: | Zhou, Bin|Guo, Weidong|Sun, Chuandong|Zhang, Bingyuan|Zheng, Fang | ||||||||||
| PMID: | 29899418 | ||||||||||
| 33. | |||||||||||
| Journal: | Br J Cancer. 2018 Oct 15. pii: 10.1038/s41416-018-0246-z. | ||||||||||
| Title: | Galunisertib plus gemcitabine vs. gemcitabine for first-line treatment of patients with unresectable pancreatic cancer. | ||||||||||
| Author: | Melisi, Davide|Garcia-Carbonero, Rocio|Macarulla, Teresa|Pezet, Denis|Deplanque, Gael|Fuchs, Martin|Trojan, Jorg|Oettle, Helmut|Kozloff, Mark|Cleverly, Ann|Smith, Claire|Estrem, Shawn T|Gueorguieva, Ivelina|Lahn, Michael M F|Blunt, Al|Benhadji, Karim A|Ta | ||||||||||
| PMID: | 30318515 | ||||||||||