Primary Site >> Liver Cancer

Gene >> TGFB1

Journal: Hepatology. 1996 May;23(5):1268-75.
Title: Hepatic silicosis, cirrhosis, and liver tumors in mice and hamsters: studies of transforming growth factor beta expression.
Author: Williams, A O|Knapton, A D
PMID: 8621163
Journal: Cell Death Differ. 1999 Feb;6(2):190-200.
Title: Inhibition of transforming growth factor beta1-induced hepatoma cell apoptosis by liver tumor promoters: characterization of primary signaling events and effects on CPP32-like caspase activity.
Author: Buchmann, A|Willy, C|Buenemann, C L|Stroh, C|Schmiechen, A|Schwarz, M
PMID: 10200566
Journal: Oncology. 2000 Apr;58(3):261-70.
Title: Secretion of extracellular matrix (fibronectin), growth factor (transforming growth factor beta) and protease (cathepsin D) by hepatoma cells.
Author: Ito, H|Miyazaki, M|Nishimura, F|Nakajima, N
PMID: 10765130
Journal: Int J Oncol. 2000 Mar;16(3):599-610.
Title: Transforming growth factor-beta and response to anticancer therapies in human liver and gastric tumors in vitro and in vivo.
Author: Liu, P|Menon, K|Alvarez, E|Lu, K|Teicher, B A
PMID: 10675495
Journal: Carcinogenesis. 2001 Mar;22(3):447-52.
Title: Transforming growth factor-beta1-induced Smad signaling, cell-cycle arrest and apoptosis in hepatoma cells.
Author: Buenemann, C L|Willy, C|Buchmann, A|Schmiechen, A|Schwarz, M
PMID: 11238185
Journal: Carcinogenesis. 2003 Nov;24(11):1801-9.
Title: Expression of activins C and E induces apoptosis in human and rat hepatoma cells.
Author: Vejda, Susanne|Erlach, Natascha|Peter, Barbara|Drucker, Claudia|Rossmanith, Walter|Pohl, Jens|Schulte-Hermann, Rolf|Grusch, Michael
PMID: 12949049
Journal: Zhonghua Wai Ke Za Zhi. 2005 Jun 1;43(11):721-5.
Title: [The study of inhibition effect of octreotide on the growth of hepatocellular carcinoma xenografts in situ in nude mice].
Author: Hua, Yun-peng|Huang, Jie-fu|Liang, Li-jian|Li, Shao-qiang|Lai, Jia-ming|Liang, Hui-zhen
PMID: 16008961
Journal: Zhonghua Wai Ke Za Zhi. 2005 Jul 1;43(13):846-9.
Title: [Expression of Smad4 and transforming growth factor-beta1, transforming growth factor-beta receptor II in cholangiocarcinoma tissue and its biological significance].
Author: Zhang, Bing-yuan|Zhang, Jian-yu|Zhao, Kai|Wu, Li-qun
PMID: 16083599
Journal: Oncogene. 2006 Jun 26;25(27):3787-800.
Title: Dysregulation of growth factor signaling in human hepatocellular carcinoma.
Author: Breuhahn, K|Longerich, T|Schirmacher, P
PMID: 16799620
Journal: Ann N Y Acad Sci. 2006 Nov;1089:98-103.
Title: Regulatory cytokine gene polymorphisms and risk of colorectal carcinoma.
Author: Crivello, Antonino|Giacalone, Antonio|Vaglica, Marina|Scola, Letizia|Forte, Giusi Irma|Macaluso, Maria Catena|Raimondi, Cristina|Di Noto, Laura|Bongiovanni, Alberto|Accardo, Angela|Candore, Giuseppina|Palmeri, Laura|Verna, Roberto|Caruso, Calogero|Lio, Do
PMID: 17261758
Journal: Toxicology. 2008 Apr 18;246(2-3):242-7.
Title: Repression of Ah receptor and induction of transforming growth factor-beta genes in DEN-induced mouse liver tumors.
Author: Peng, Li|Mayhew, Christopher N|Schnekenburger, Michael|Knudsen, Erik S|Puga, Alvaro
PMID: 18282651
Journal: Virus Res. 2010 Jan;147(1):67-76.
Title: Adenovirus E1A and E1B-19K proteins protect human hepatoma cells from transforming growth factor beta1-induced apoptosis.
Author: Tarakanova, Vera L|Wold, William S M
PMID: 19854227
Journal: Hepatology. 2010 May;51(5):1635-44.
Title: Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor-beta.
Author: You, Hanning|Ding, Wei|Rountree, C Bart
PMID: 20196115
Journal: Cancer Sci. 2010 Dec;101(12):2546-53.
Title: Human mesenchymal stem cells inhibit metastasis of a hepatocellular carcinoma model using the MHCC97-H cell line.
Author: Li, Guo-Cai|Ye, Qing-Hai|Xue, Yu-Hua|Sun, Hai-Jing|Zhou, Hai-Jun|Ren, Ning|Jia, Hu-Liang|Shi, Jiong|Wu, Jin-Cai|Dai, Chun|Dong, Qiong-Zhu|Qin, Lun-Xiu
PMID: 20942864
Journal: Genes Chromosomes Cancer. 2011 Feb;50(2):122-35.
Title: Sulfatase 1 and sulfatase 2 in hepatocellular carcinoma: associated signaling pathways, tumor phenotypes, and survival.
Author: Yang, Ju Dong|Sun, Zhifu|Hu, Chunling|Lai, Jinping|Dove, Rebecca|Nakamura, Ikuo|Lee, Ju-Seog|Thorgeirsson, Snorri S|Kang, Koo Jeong|Chu, In-Sun|Roberts, Lewis R
PMID: 21104785
Journal: J Lipid Res. 2012 Dec;53(12):2698-707.
Title: TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury.
Author: Matsubara, Tsutomu|Tanaka, Naoki|Sato, Misako|Kang, Dong Wook|Krausz, Kristopher W|Flanders, Kathleen C|Ikeda, Kazuo|Luecke, Hans|Wakefield, Lalage M|Gonzalez, Frank J
PMID: 23034213
Journal: Genes Chromosomes Cancer. 2013 Mar;52(3):225-36.
Title: The human sulfatase 2 inhibitor 2,4-disulfonylphenyl-tert-butylnitrone (OKN-007) has an antitumor effect in hepatocellular carcinoma mediated via suppression of TGFB1/SMAD2 and Hedgehog/GLI1 signaling.
Author: Zheng, Xin|Gai, Xiaohong|Han, Shaoshan|Moser, Catherine D|Hu, Chunling|Shire, Abdirashid M|Floyd, Robert A|Roberts, Lewis R
PMID: 23109092
Journal: Hepatology. 2013 Apr;57(4):1484-97.
Title: Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma.
Author: Yamashita, Taro|Honda, Masao|Nakamoto, Yasunari|Baba, Masayo|Nio, Kouki|Hara, Yasumasa|Zeng, Sha Sha|Hayashi, Takehiro|Kondo, Mitsumasa|Takatori, Hajime|Yamashita, Tatsuya|Mizukoshi, Eishiro|Ikeda, Hiroko|Zen, Yoh|Takamura, Hiroyuki|Wang, Xin Wei|Kaneko,
PMID: 23174907
Journal: Exp Ther Med. 2013 Jan;5(1):119-127.
Title: Evaluation of TGFbeta, XPO4, elF5A2 and ANGPTL4 as biomarkers in HCC.
Author: Zhang, Hao|Wei, Shi|Ning, Song|Jie, Yungliu|Ru, Yukang|Gu, Yuchun
PMID: 23251252
Journal: J Cancer Res Clin Oncol. 2013 Jun;139(6):1033-42.
Title: KLF8 involves in TGF-beta-induced EMT and promotes invasion and migration in gastric cancer cells.
Author: Zhang, Hui|Liu, Lili|Wang, Yafang|Zhao, Guohong|Xie, Rougang|Liu, Changhao|Xiao, Xiao|Wu, Kaichun|Nie, Yongzhan|Zhang, Hongbo|Fan, Daiming
PMID: 23504025
Journal: PLoS One. 2013 Nov 4;8(11):e78624.
Title: iSubgraph: integrative genomics for subgroup discovery in hepatocellular carcinoma using graph mining and mixture models.
Author: Ozdemir, Bahadir|Abd-Almageed, Wael|Roessler, Stephanie|Wang, Xin Wei
PMID: 24223834
Journal: PLoS One. 2014 May 5;9(5):e96799.
Title: Harnessing high density lipoproteins to block transforming growth factor beta and to inhibit the growth of liver tumor metastases.
Author: Medina-Echeverz, Jose|Fioravanti, Jessica|Diaz-Valdes, Nancy|Frank, Kathrin|Aranda, Fernando|Gomar, Celia|Ardaiz, Nuria|Dotor, Javier|Umansky, Viktor|Prieto, Jesus|Berraondo, Pedro
PMID: 24797128
Journal: Oncology. 2014;87(1):21-9.
Title: Summary of bi-shRNA/GM-CSF augmented autologous tumor cell immunotherapy (FANG) in advanced cancer of the liver.
Author: Nemunaitis, John|Barve, Minal|Orr, Douglas|Kuhn, Joseph|Magee, Mitchell|Lamont, Jeffrey|Bedell, Cynthia|Wallraven, Gladice|Pappen, Beena O|Roth, Alyssa|Horvath, Staci|Nemunaitis, Derek|Kumar, Padmasini|Maples, Phillip B|Senzer, Neil
PMID: 24968881
Journal: Hepatology. 2014 Dec;60(6):2077-90.
Title: Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells.
Author: Dubois-Pot-Schneider, Helene|Fekir, Karim|Coulouarn, Cedric|Glaise, Denise|Aninat, Caroline|Jarnouen, Kathleen|Le Guevel, Remy|Kubo, Takashi|Ishida, Seiichi|Morel, Fabrice|Corlu, Anne
PMID: 25098666
Journal: Eur J Med Res. 2015 May 24;20:56.
Title: Effects of transforming growth factor beta-1 infected human bone marrow mesenchymal stem cells on high- and low-metastatic potential hepatocellular carcinoma.
Author: Li, Tianran|Zhao, Shaohong|Song, Bin|Wei, Zhengmao|Lu, Guangming|Zhou, Jun|Huo, Tianlong
PMID: 26003220
Journal: Ann Surg Oncol. 2015 Dec;22 Suppl 3:S915-22.
Title: A Long Non-coding RNA Activated by Transforming Growth Factor-beta is an Independent Prognostic Marker of Gastric Cancer.
Author: Saito, Tomoko|Kurashige, Junji|Nambara, Sho|Komatsu, Hisateru|Hirata, Hidenari|Ueda, Masami|Sakimura, Shotaro|Uchi, Ryutaro|Takano, Yuki|Shinden, Yoshiaki|Iguchi, Tomohiro|Eguchi, Hidetoshi|Ehata, Shogo|Murakami, Kazunari|Sugimachi, Keishi|Mimori, Koshi
PMID: 25986864
Journal: In Vivo. 2015 May-Jun;29(3):327-40.
Title: Monoclonal antibody against transforming growth factor Beta 1 does not influence liver regeneration after resection in large animal experiments.
Author: Bruha, Jan|Vycital, Ondrej|Tonar, Zbynek|Mirka, Hynek|Haidingerova, Lenka|Benes, Jan|Palek, Richard|Skala, Martin|Treska, Vladislav|Liska, Vaclav
PMID: 25977378
Journal: BMC Cancer. 2015 Mar 27;15:188.
Title: The role of multipotent cancer associated fibroblasts in hepatocarcinogenesis.
Author: Sukowati, Caecilia Hapsari Ceriapuri|Anfuso, Beatrice|Croce, Lory Saveria|Tiribelli, Claudio
PMID: 25879842
Journal: Clin Cancer Res. 2015 Jul 1;21(13):3081-91.
Title: Keratin 19, a Cancer Stem Cell Marker in Human Hepatocellular Carcinoma.
Author: Kawai, Takayuki|Yasuchika, Kentaro|Ishii, Takamichi|Katayama, Hokahiro|Yoshitoshi, Elena Yukie|Ogiso, Satoshi|Kita, Sadahiko|Yasuda, Katsutaro|Fukumitsu, Ken|Mizumoto, Masaki|Hatano, Etsuro|Uemoto, Shinji
PMID: 25820415
Journal: Cell Tissue Res. 2015 Mar;359(3):829-39.
Title: Co-migration of colon cancer cells and CAFs induced by TGFbeta(1) enhances liver metastasis.
Author: Gonzalez-Zubeldia, Idoia|Dotor, Javier|Redrado, Miriam|Bleau, Anne-Marie|Manrique, Irene|de Aberasturi, Arrate L|Villalba, Maria|Calvo, Alfonso
PMID: 25557989
Journal: Am J Pathol. 2015 Feb;185(2):325-34.
Title: A new Mdr2(-/-) mouse model of sclerosing cholangitis with rapid fibrosis progression, early-onset portal hypertension, and liver cancer.
Author: Ikenaga, Naoki|Liu, Susan B|Sverdlov, Deanna Y|Yoshida, Shuhei|Nasser, Imad|Ke, Qingen|Kang, Peter M|Popov, Yury
PMID: 25478810
Journal: Mol Cancer. 2015 Mar 24;14:64.
Title: The role of TGFBI (betaig-H3) in gastrointestinal tract tumorigenesis.
Author: Han, Bing|Cai, Haolei|Chen, Ying|Hu, Bing|Luo, Hongyu|Wu, Yulian|Wu, Jiangping
PMID: 25889002
Journal: Mol Med Rep. 2016 Jan;13(1):522-8.
Title: NIM811 downregulates transforming growth factorbeta signal transduction in vivo and in vitro.
Author: Chen, Jing|Liu, Dian-Gang|Wang, Hui|Wu, Xiao-Ning|Cong, Min|You, Hong|Jia, Ji-Dong
PMID: 26573209
Journal: Nat Commun. 2016 Mar 18;7:11012.
Title: Differential TGFbeta pathway targeting by miR-122 in humans and mice affects liver cancer metastasis.
Author: Yin, Shenyi|Fan, Yu|Zhang, Hanshuo|Zhao, Zhihua|Hao, Yang|Li, Juan|Sun, Changhong|Yang, Junyu|Yang, Zhenjun|Yang, Xiao|Lu, Jian|Xi, Jianzhong Jeff
PMID: 26987776
Journal: Onco Targets Ther. 2016 Mar 17;9:1623-33.
Title: miR-663 overexpression induced by endoplasmic reticulum stress modulates hepatocellular carcinoma cell apoptosis via transforming growth factor beta 1.
Author: Huang, Yawei|Liu, Jiatao|Fan, Lulu|Wang, Fang|Yu, Hanqing|Wei, Wei|Sun, Guoping
PMID: 27073326
Journal: Oncotarget. 2016 Dec 20;7(51):84695-84704.
Title: Enhanced circulating transforming growth factor beta 1 is causally associated with an increased risk of hepatocellular carcinoma: a mendelian randomization meta-analysis.
Author: Lu, Wei-Qun|Qiu, Ji-Liang|Huang, Zhi-Liang|Liu, Hai-Ying
PMID: 27835897
Journal: Cell Mol Gastroenterol Hepatol. 2017 Jan 17;3(3):484-499.
Title: Serotonin Activated Hepatic Stellate Cells Contribute to Sex Disparity in Hepatocellular Carcinoma.
Author: Yang, Qiqi|Yan, Chuan|Yin, Chunyue|Gong, Zhiyuan
PMID: 28462385
Journal: Oncotarget. 2017 Aug 18;8(44):77096-77109.
Title: Chronically high level of tgfb1a induction causes both hepatocellular carcinoma and cholangiocarcinoma via a dominant Erk pathway in zebrafish.
Author: Yan, Chuan|Yang, Qiqi|Shen, Han-Ming|Spitsbergen, Jan M|Gong, Zhiyuan
PMID: 29100373
Journal: Cell Death Dis. 2017 Oct 12;8(10):e3098.
Title: The level of caveolin-1 expression determines response to TGF-beta as a tumour suppressor in hepatocellular carcinoma cells.
Author: Moreno-Caceres, Joaquim|Caballero-Diaz, Daniel|Nwosu, Zeribe Chike|Meyer, Christoph|Lopez-Luque, Judit|Malfettone, Andrea|Lastra, Raquel|Serrano, Teresa|Ramos, Emilio|Dooley, Steven|Fabregat, Isabel
PMID: 29022911
Journal: J Hum Genet. 2017 Nov;62(11):969-977.
Title: Genetic variants underlying vitamin D metabolism and VDR-TGFbeta-1-SMAD3 interaction may impact on HCV progression: a study based on dbGaP data from the HALT-C study.
Author: de Azevedo, Laura A|Matte, Ursula|da Silveira, Themis R|Alvares-da-Silva, Mario R
PMID: 28703134
Journal: J Mater Sci Mater Med. 2017 Aug;28(8):120.
Title: Hybrid polymeric-protein nano-carriers (HPPNC) for targeted delivery of TGFbeta inhibitors to hepatocellular carcinoma cells.
Author: Hanafy, Nemany A N|Quarta, Alessandra|Di Corato, Riccardo|Dini, Luciana|Nobile, Concetta|Tasco, Vittorianna|Carallo, Sonia|Cascione, Mariafrancesca|Malfettone, Andrea|Soukupova, Jitka|Rinaldi, Rosaria|Fabregat, Isabel|Leporatti, Stefano
PMID: 28685231
Journal: Med Oncol. 2017 Jun;34(6):101.
Title: The identification of key genes and pathways in hepatocellular carcinoma by bioinformatics analysis of high-throughput data.
Author: Zhang, Chaoyang|Peng, Li|Zhang, Yaqin|Liu, Zhaoyang|Li, Wenling|Chen, Shilian|Li, Guancheng
PMID: 28432618
Journal: PLoS One. 2017 Mar 23;12(3):e0174265.
Title: Targeted deep sequencing of plasma circulating cell-free DNA reveals Vimentin and Fibulin 1 as potential epigenetic biomarkers for hepatocellular carcinoma.
Author: Holmila, Reetta|Sklias, Athena|Muller, David C|Degli Esposti, Davide|Guilloreau, Paule|Mckay, James|Sangrajrang, Suleeporn|Srivatanakul, Petcharin|Hainaut, Pierre|Merle, Philippe|Herceg, Zdenko|Nogueira da Costa, Andre
PMID: 28333958
Journal: Cancer Res. 2017 Mar 15;77(6):1395-1407.
Title: Tumor-Associated Neutrophils and Macrophages Promote Gender Disparity in Hepatocellular Carcinoma in Zebrafish.
Author: Yan, Chuan|Yang, Qiqi|Gong, Zhiyuan
PMID: 28202512
Journal: Cancer Lett. 2017 Apr 28;392:39-50.
Title: Transforming growth factor-beta-induced plasticity causes a migratory stemness phenotype in hepatocellular carcinoma.
Author: Malfettone, Andrea|Soukupova, Jitka|Bertran, Esther|Crosas-Molist, Eva|Lastra, Raquel|Fernando, Joan|Koudelkova, Petra|Rani, Bhavna|Fabra, Angels|Serrano, Teresa|Ramos, Emilio|Mikulits, Wolfgang|Giannelli, Gianluigi|Fabregat, Isabel
PMID: 28161507
Journal: Metabolism. 2017 Jan;66:32-44.
Title: Amelioration of non-alcoholic fatty liver disease with NPC1L1-targeted IgY or n-3 polyunsaturated fatty acids in mice.
Author: Bae, Jin-Sik|Park, Jong-Min|Lee, Junghoon|Oh, Byung-Chul|Jang, Sang-Ho|Lee, Yun Bin|Han, Young-Min|Ock, Chan-Young|Cha, Ji-Young|Hahm, Ki-Baik
PMID: 27923447
Journal: Sci Rep. 2018 Feb 5;8(1):2362.
Title: Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH.
Author: Shiba, Kumiko|Tsuchiya, Kyoichiro|Komiya, Chikara|Miyachi, Yasutaka|Mori, Kentaro|Shimazu, Noriko|Yamaguchi, Shinobu|Ogasawara, Naomi|Katoh, Makoto|Itoh, Michiko|Suganami, Takayoshi|Ogawa, Yoshihiro
PMID: 29402900
Journal: Cancer Manag Res. 2018 Apr 10;10:679-696.
Title: Marker of proliferation Ki-67 expression is associated with transforming growth factor beta 1 and can predict the prognosis of patients with hepatic B virus-related hepatocellular carcinoma.
Author: Yang, Chengkun|Su, Hao|Liao, Xiwen|Han, Chuangye|Yu, Tingdong|Zhu, Guangzhi|Wang, Xiangkun|Winkler, Cheryl Ann|O'Brien, Stephen J|Peng, Tao
PMID: 29692627
Journal: Hum Gene Ther. 2018 May 3.
Title: External Beam Radiation Therapy Enhances Mesenchymal Stem Cell-Mediated Sodium-Iodide Symporter Gene Delivery.
Author: Schug, Christina|Sievert, Wolfgang|Urnauer, Sarah|Muller, Andrea M|Schmohl, Kathrin A|Wechselberger, Alexandra|Schwenk, Nathalie|Lauber, Kirsten|Schwaiger, Markus|Multhoff, Gabriele|Wagner, Ernst|Nelson, Peter J|Spitzweg, Christine
PMID: 29724129
Journal: Sci Rep. 2018 May 31;8(1):8495.
Title: Interaction of hepatic stellate cells with neutrophils and macrophages in the liver following oncogenic kras activation in transgenic zebrafish.
Author: Yang, Qiqi|Yan, Chuan|Gong, Zhiyuan
PMID: 29855567
Journal: Autophagy. 2018 Aug 21:1-21.
Title: Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells.
Author: Zhang, Zili|Yao, Zhen|Wang, Ling|Ding, Hai|Shao, Jiangjuan|Chen, Anping|Zhang, Feng|Zheng, Shizhong
PMID: 30081711
Journal: Cytokine. 2018 Aug 7. pii: S1043-4666(18)30330-2.
Title: Essential role of suppressor of cytokine signaling 1 (SOCS1) in hepatocytes and macrophages in the regulation of liver fibrosis.
Author: Mafanda, Euphrasie Kawila|Kandhi, Rajani|Bobbala, Diwakar|Khan, Md Gulam Musawwir|Nandi, Madhuparna|Menendez, Alfredo|Ramanathan, Sheela|Ilangumaran, Subburaj
PMID: 30097285
Journal: Pathol Oncol Res. 2018 Aug 14. pii: 10.1007/s12253-018-0458-9.
Title: Chronic Hyperglycaemia Induced Alterations of Hepatic Stellate Cells Differ from the Effect of TGFB1, and Point toward Metabolic Stress.
Author: Kiss, Katalin|Regos, Eszter|Rada, Kristof|Firneisz, Gabor|Baghy, Kornelia|Kovalszky, Ilona
PMID: 30109568
Journal: Exp Ther Med. 2018 Aug;16(2):1052-1060.
Title: Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocarcinogenesis via modulating TGF-beta/TbetaR and Imp7/8.
Author: Wu, Chao|Kan, Hongwei|Hu, Min|Liu, Xin|Boye, Alex|Jiang, Yufeng|Wu, Jiajun|Wang, Jiyu|Yang, Xiaochuan|Yang, Yan
PMID: 30112050
Journal: Oncogene. 2018 Oct 26. pii: 10.1038/s41388-018-0552-1.
Title: Bclaf1 promotes angiogenesis by regulating HIF-1alpha transcription in hepatocellular carcinoma.
Author: Wen, Ying|Zhou, Xueqiong|Lu, Meiting|He, Meiling|Tian, Ye|Liu, Lixia|Wang, Mengnan|Tan, Wenchong|Deng, Yaotang|Yang, Xushan|Mayer, Matthias P|Zou, Fei|Chen, Xuemei
PMID: 30367150