Primary Site >> Pancreatic Cancer

Gene >> RRM1

Journal: Cancer Res. 2006 Apr 1;66(7):3928-35.
Title: Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine.
Author: Giovannetti, Elisa|Del Tacca, Mario|Mey, Valentina|Funel, Niccola|Nannizzi, Sara|Ricci, Sergio|Orlandini, Cinzia|Boggi, Ugo|Campani, Daniela|Del Chiaro, Marco|Iannopollo, Mauro|Bevilacqua, Generoso|Mosca, Franco|Danesi, Romano
PMID: 16585222
Journal: Int J Cancer. 2007 Mar 15;120(6):1355-63.
Title: Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer.
Author: Nakahira, Shin|Nakamori, Shoji|Tsujie, Masanori|Takahashi, Yuji|Okami, Jiro|Yoshioka, Shinichi|Yamasaki, Makoto|Marubashi, Shigeru|Takemasa, Ichiro|Miyamoto, Atsushi|Takeda, Yutaka|Nagano, Hiroaki|Dono, Keizo|Umeshita, Koji|Sakon, Masato|Monden, Morito
PMID: 17131328
Journal: Br J Cancer. 2007 Feb 12;96(3):457-63.
Title: Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells.
Author: Nakano, Y|Tanno, S|Koizumi, K|Nishikawa, T|Nakamura, K|Minoguchi, M|Izawa, T|Mizukami, Y|Okumura, T|Kohgo, Y
PMID: 17224927
Journal: Anticancer Res. 2008 Jul-Aug;28(4B):2205-12.
Title: Down-regulation of deoxycytidine kinase enhances acquired resistance to gemcitabine in pancreatic cancer.
Author: Ohhashi, Seiji|Ohuchida, Kenoki|Mizumoto, Kazuhiro|Fujita, Hayato|Egami, Takuya|Yu, Jun|Toma, Hiroki|Sadatomi, Shoko|Nagai, Eishi|Tanaka, Masao
PMID: 18751396
Journal: Oncogene. 2009 Aug 13;28(32):2903-9.
Title: Significance of RRM1 and ERCC1 expression in resectable pancreatic adenocarcinoma.
Author: Akita, H|Zheng, Z|Takeda, Y|Kim, C|Kittaka, N|Kobayashi, S|Marubashi, S|Takemasa, I|Nagano, H|Dono, K|Nakamori, S|Monden, M|Mori, M|Doki, Y|Bepler, G
PMID: 19543324
Journal: Cancer Invest. 2010 Feb;28(2):172-80.
Title: In situ protein expression of RRM1, ERCC1, and BRCA1 in metastatic breast cancer patients treated with gemcitabine-based chemotherapy.
Author: Metro, G|Zheng, Z|Fabi, A|Schell, M|Antoniani, B|Mottolese, M|Monteiro, A N|Vici, P|Lara Rivera, S|Boulware, D|Cognetti, F|Bepler, G
PMID: 19968494
Journal: Clin Cancer Res. 2010 Jan 1;16(1):320-9.
Title: Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity.
Author: Okazaki, Taro|Javle, Milind|Tanaka, Motofumi|Abbruzzese, James L|Li, Donghui
PMID: 20028759
Journal: Int J Oncol. 2010 Feb;36(2):341-9.
Title: Tranilast strongly sensitizes pancreatic cancer cells to gemcitabine via decreasing protein expression of ribonucleotide reductase 1.
Author: Mitsuno, Mayumi|Kitajima, Yoshihiko|Ohtaka, Kazuma|Kai, Keita|Hashiguchi, Kazuyoshi|Nakamura, Jun|Hiraki, Masatsugu|Noshiro, Hirokazu|Miyazaki, Kohji
PMID: 20043067
Journal: Cancer. 2010 Nov 15;116(22):5325-35.
Title: Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer.
Author: Tanaka, Motofumi|Javle, Milind|Dong, Xiaoqun|Eng, Cathy|Abbruzzese, James L|Li, Donghui
PMID: 20665488
Journal: Cancer. 2011 Jul 15;117(14):3126-34.
Title: Prognostic roles of human equilibrative transporter 1 (hENT-1) and ribonucleoside reductase subunit M1 (RRM1) in resected pancreatic cancer.
Author: Kim, Richard|Tan, Ann|Lai, Kevin K|Jiang, John|Wang, Yixen|Rybicki, Lisa A|Liu, Xiulu
PMID: 21264835
Journal: Int J Oncol. 2011 Aug;39(2):473-82.
Title: Predicting the chemosensitivity of pancreatic cancer cells by quantifying the expression levels of genes associated with the metabolism of gemcitabine and 5-fluorouracil.
Author: Kurata, Nobuaki|Fujita, Hayato|Ohuchida, Kenoki|Mizumoto, Kazuhiro|Mahawithitwong, Prawej|Sakai, Hiroshi|Onimaru, Manabu|Manabe, Tatsuya|Ohtsuka, Takao|Tanaka, Masao
PMID: 21617862
Journal: Pancreas. 2011 Jul;40(5):657-63.
Title: Genetic effects and modifiers of radiotherapy and chemotherapy on survival in pancreatic cancer.
Author: Zeng, Hongmei|Yu, Herbert|Lu, Lingeng|Jain, Dhanpat|Kidd, Mark S|Saif, M Wasif|Chanock, Stephen J|Hartge, Patricia|Risch, Harvey A
PMID: 21487324
Journal: Cancer Sci. 2011 Mar;102(3):622-9.
Title: Disrupted plasma membrane localization of equilibrative nucleoside transporter 2 in the chemoresistance of human pancreatic cells to gemcitabine (dFdCyd).
Author: Nishio, Ren|Tsuchiya, Hiroyuki|Yasui, Toshihiro|Matsuura, Shizuka|Kanki, Keita|Kurimasa, Akihiro|Hisatome, Ichiro|Shiota, Goshi
PMID: 21205085
Journal: Lancet Oncol. 2011 Jul;12(7):693-702.
Title: The ribonucleotide reductase large subunit (RRM1) as a predictive factor in patients with cancer.
Author: Jordheim, Lars Petter|Seve, Pascal|Tredan, Olivier|Dumontet, Charles
PMID: 21163702
Journal: Invest New Drugs. 2012 Jun;30(3):1164-74.
Title: A phase II trial of erlotinib in combination with gemcitabine and capecitabine in previously untreated metastatic/recurrent pancreatic cancer: combined analysis with translational research.
Author: Oh, Do-Youn|Lee, Keun Wook|Lee, Kyung-Hee|Sohn, Chang-Hak|Park, Young Suk|Zang, Dae Young|Ryoo, Hun-Mo|Song, Hong-Suk|Kim, Jin-Soo|Kang, Hye-Jin|Kim, Bong-Seog|Bang, Yung-Jue
PMID: 21404106
Journal: Hepatogastroenterology. 2012 Jul-Aug;59(117):1609-13.
Title: Prediction of a side effect and efficacy of adjuvant chemotherapy with gemcitabine for post operative patient of pancreatic cancer by a genetic polymorphism analysis.
Author: Kasuya, Kazuhiko|Tsuchida, Akihiko|Nagakawa, Yuichi|Suzuki, Yoshiaki|Suzuki, Minako|Aoki, Tatsuya|Abe, Yuta|Shimazu, Motohide|Itoi, Takao|Sofuni, Atsushi
PMID: 22155850
Journal: BMC Cancer. 2012 Mar 22;12:104.
Title: Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma?
Author: Valsecchi, Matias E|Holdbrook, Thomas|Leiby, Benjamin E|Pequignot, Edward|Littman, Susan J|Yeo, Charles J|Brody, Jonathan R|Witkiewicz, Agnieszka K
PMID: 22436573
Journal: Chin J Cancer. 2012 Oct;31(10):476-83.
Title: Expression of RRM1 and its association with resistancy to gemcitabine-based chemotherapy in advanced nasopharyngeal carcinoma.
Author: Zhao, Li-Ping|Xue, Cong|Zhang, Jian-Wei|Hu, Zhi-Huang|Zhao, Yuan-Yuan|Zhang, Jing|Huang, Yan|Zhao, Hong-Yun|Zhang, Li
PMID: 22692073
Journal: Asian Pac J Cancer Prev. 2013;14(7):4261-5.
Title: Predictive and prognostic roles of ribonucleotide reductase M1 in patients with pancreatic cancer treated with gemcitabine: a meta-analysis.
Author: Zhang, Xiong|Jin, Fen-Shu|Zhang, Li-Guo|Chen, Rui-Xue|Zhao, Jin-Hui|Wang, Yan-Nan|Wang, En-Fu|Jiang, Zhen-Dong
PMID: 23991987
Journal: Hepatogastroenterology. 2013 Sep;60(126):1484-7.
Title: In vitro effects of lapatinib with gemcitabine for pancreatic cancer cells.
Author: Murata, Akihiro|Nakata, Bunzo|Komoto, Masahiro|Hirata, Keiichiro|Kimura, Kenjiro|Amano, Ryosuke|Hirakawa, Kosei
PMID: 23933942
Journal: Biomark Med. 2013 Aug;7(4):663-71.
Title: Do hENT1 and RRM1 predict the clinical benefit of gemcitabine in pancreatic cancer?
Author: Jordheim, Lars Petter|Dumontet, Charles
PMID: 23905902
Journal: Surgery. 2013 Apr;153(4):565-75.
Title: Combined analysis of intratumoral human equilibrative nucleoside transporter 1 (hENT1) and ribonucleotide reductase regulatory subunit M1 (RRM1) expression is a powerful predictor of survival in patients with pancreatic carcinoma treated with adjuvant gem
Author: Nakagawa, Naoya|Murakami, Yoshiaki|Uemura, Kenichiro|Sudo, Takeshi|Hashimoto, Yasushi|Kondo, Naru|Sueda, Taijiro
PMID: 23253379
Journal: Oncogene. 2013 Mar 28;32(13):1714-23.
Title: The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family.
Author: Skrypek, N|Duchene, B|Hebbar, M|Leteurtre, E|van Seuningen, I|Jonckheere, N
PMID: 22580602
Journal: Cancer. 2013 Jan 15;119(2):445-53.
Title: An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: implication
Author: Fisher, Sarah B|Patel, Sameer H|Bagci, Pelin|Kooby, David A|El-Rayes, Bassel F|Staley, Charles A 3rd|Adsay, N Volkan|Maithel, Shishir K
PMID: 22569992
Journal: World J Surg Oncol. 2013 May 27;11:117.
Title: Prognostic predictive values of gemcitabine sensitivity-related gene products for unresectable or recurrent biliary tract cancer treated with gemcitabine alone.
Author: Murata, Akihiro|Amano, Ryosuke|Yamada, Nobuya|Kimura, Kenjiro|Yashiro, Masakazu|Nakata, Bunzo|Hirakawa, Kosei
PMID: 23710668
Journal: JOP. 2014 Jul 28;15(4):299-302.
Title: Pharmacogenetics in neuroendocrine tumors of the pancreas.
Author: Rizvi, Syed Mujtaba|Wong, Joyce|Saif, Muhammad Wasif|Jia, Yuxia
PMID: 25076325
Journal: Anticancer Drugs. 2015 Jan;26(1):90-100.
Title: Acquired resistance to gemcitabine and cross-resistance in human pancreatic cancer clones.
Author: Yoneyama, Hiroshi|Takizawa-Hashimoto, Asako|Takeuchi, Osamu|Watanabe, Yukiko|Atsuda, Koichiro|Asanuma, Fumiki|Yamada, Yoshinori|Suzuki, Yukio
PMID: 25187316
Journal: Oncol Rep. 2015 Jan;33(1):383-90.
Title: Establishment of human pancreatic cancer gemcitabineresistant cell line with ribonucleotide reductase overexpression.
Author: Wang, Congfei|Zhang, Weiwei|Fu, Mingjuan|Yang, Aiqin|Huang, Heguang|Xie, Jieming
PMID: 25394408
Journal: J Pharmacol Sci. 2015 Mar;127(3):319-25.
Title: Ribonucleotide reductase is an effective target to overcome gemcitabine resistance in gemcitabine-resistant pancreatic cancer cells with dual resistant factors.
Author: Minami, Kentaro|Shinsato, Yoshinari|Yamamoto, Masatatsu|Takahashi, Homare|Zhang, Shaoxuan|Nishizawa, Yukihiko|Tabata, Sho|Ikeda, Ryuji|Kawahara, Kohich|Tsujikawa, Kazutake|Chijiiwa, Kazuo|Yamada, Katsushi|Akiyama, Shin-ichi|Perez-Torras, Sandra|Pastor-Ang
PMID: 25837929
Journal: Clin Cancer Res. 2015 Dec 15;21(24):5563-77.
Title: The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy in Pancreatic Cancer Models by Altering Ribonucleotide Reductase Subunit-1 (RRM1).
Author: Vena, Francesca|Li Causi, Eleonora|Rodriguez-Justo, Manuel|Goodstal, Samantha|Hagemann, Thorsten|Hartley, John A|Hochhauser, Daniel
PMID: 26228206
Journal: World J Gastrointest Oncol. 2015 Sep 15;7(9):132-40.
Title: Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review.
Author: Borazanci, Erkut|Millis, Sherri Z|Korn, Ron|Han, Haiyong|Whatcott, Clifford J|Gatalica, Zoran|Barrett, Michael T|Cridebring, Derek|Von Hoff, Daniel D
PMID: 26380056
Journal: Contemp Oncol (Pozn). 2015;19(3):207-13.
Title: ERCC1 and RRM1 as a predictive parameter for non-small cell lung, ovarian or pancreas cancer treated with cisplatin and/or gemcitabine.
Author: Ulker, Mehmet|Duman, Berna Bozkurt|Sahin, Berksoy|Gumurdulu, Derya
PMID: 26557761
Journal: Pancreas. 2016 Nov;45(10):1485-1493.
Title: Precision Medicine and Pancreatic Cancer: A Gemcitabine Pathway Approach.
Author: Farrell, James J|Moughan, Jennifer|Wong, Jonathan L|Regine, William F|Schaefer, Paul|Benson, Al B 3rd|Macdonald, John S|Liu, Xiyong|Yen, Yun|Lai, Raymond|Zheng, Zhong|Bepler, Gerold|Guha, Chandan|Elsaleh, Hany
PMID: 27748721
Journal: Cancer Lett. 2016 Apr 1;373(1):130-137.
Title: MicroRNA-101-3p reverses gemcitabine resistance by inhibition of ribonucleotide reductase M1 in pancreatic cancer.
Author: Fan, Pei|Liu, Li|Yin, Yefeng|Zhao, Zhefu|Zhang, Yiyao|Amponsah, Prince S|Xiao, Xi|Bauer, Nathalie|Abukiwan, Alia|Nwaeburu, Clifford C|Gladkich, Jury|Gao, Chao|Schemmer, Peter|Gross, Wolfgang|Herr, Ingrid
PMID: 26828016
Journal: Mol Med Rep. 2017 Apr;15(4):1461-1470.
Title: Sclareolide enhances gemcitabineinduced cell death through mediating the NICD and Gli1 pathways in gemcitabineresistant human pancreatic cancer.
Author: Chen, Sheng|Wang, Ye|Zhang, Wen-Long|Dong, Mao-Sheng|Zhang, Jian-Hua
PMID: 28259943
Journal: J Gastrointest Oncol. 2017 Feb;8(1):164-172.
Title: Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis.
Author: Borazanci, Erkut|Millis, Sherri Z|Kimbrough, Jeffery|Doll, Nancy|Von Hoff, Daniel|Ramanathan, Ramesh K
PMID: 28280620
Journal: Front Pharmacol. 2017 Mar 27;8:155.
Title: Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine.
Author: Grixti, Justine M|O'Hagan, Steve|Day, Philip J|Kell, Douglas B
PMID: 28396636
Journal: Oncol Lett. 2017 May;13(5):3423-3430.
Title: Clinical implications of ribonucleotide reductase subunit M1 in patients with pancreatic cancer who undergo curative resection followed by adjuvant chemotherapy with gemcitabine.
Author: Aoyama, Toru|Miyagi, Yohei|Murakawa, Masaaki|Yamaoku, Koichiro|Atsumi, Yosuke|Shiozawa, Manabu|Ueno, Makoto|Morimoto, Manabu|Oshima, Takashi|Yukawa, Norio|Yoshikawa, Takaki|Rino, Yasushi|Masuda, Munetaka|Morinaga, Soichiro
PMID: 28521448
Journal: Cancer Chemother Pharmacol. 2017 Oct;80(4):765-775.
Title: MiR-608 regulating the expression of ribonucleotide reductase M1 and cytidine deaminase is repressed through induced gemcitabine chemoresistance in pancreatic cancer cells.
Author: Rajabpour, Azam|Afgar, Ali|Mahmoodzadeh, Habibollah|Radfar, Jalal-E-Din|Rajaei, Farzad|Teimoori-Toolabi, Ladan
PMID: 28887583
Journal: Oncol Lett. 2017 Nov;14(5):5400-5408.
Title: Astaxanthin inhibits gemcitabine-resistant human pancreatic cancer progression through EMT inhibition and gemcitabine resensitization.
Author: Yan, Tao|Li, Hai-Ying|Wu, Jian-Song|Niu, Qiang|Duan, Wei-Hong|Han, Qing-Zeng|Ji, Wang-Ming|Zhang, Tao|Lv, Wei
PMID: 29098031
Journal: J Clin Pharm Ther. 2018 Apr;43(2):163-169.
Title: Effect of ribonucleotide reductase M1 expression on overall survival in patients with pancreatic cancer receiving gemcitabine chemotherapy: A literature-based meta-analysis.
Author: Han, Q L|Zhou, Y H|Lyu, Y|Yan, H|Dai, G H
PMID: 29214667
Journal: Oncol Rep. 2018 Mar;39(3):1322-1330.
Title: CHK1 inhibition sensitizes pancreatic cancer cells to gemcitabine via promoting CDK-dependent DNA damage and ribonucleotide reductase downregulation.
Author: Liang, Min|Zhao, Tiangang|Ma, Linfeng|Guo, Yingjie
PMID: 29286153
Journal: Br J Cancer. 2018 Apr;118(8):1084-1088.
Title: Intratumoural expression of deoxycytidylate deaminase or ribonuceotide reductase subunit M1 expression are not related to survival in patients with resected pancreatic cancer given adjuvant chemotherapy.
Author: Elander, N O|Aughton, K|Ghaneh, P|Neoptolemos, J P|Palmer, D H|Cox, T F|Campbell, F|Costello, E|Halloran, C M|Mackey, J R|Scarfe, A G|Valle, J W|McDonald, A C|Carter, R|Tebbutt, N C|Goldstein, D|Shannon, J|Dervenis, C|Glimelius, B|Deakin, M|Charnley, R M|
PMID: 29523831
Journal: Oncotarget. 2018 Jun 19;9(47):28434-28444.
Title: Deferasirox, an oral iron chelator, with gemcitabine synergistically inhibits pancreatic cancer cell growth in vitro and in vivo.
Author: Shinoda, Shuhei|Kaino, Seiji|Amano, Shogo|Harima, Hirofumi|Matsumoto, Toshihiko|Fujisawa, Koichi|Takami, Taro|Yamamoto, Naoki|Yamasaki, Takahiro|Sakaida, Isao
PMID: 29983871
Journal: Pancreatology. 2018 Aug 22. pii: S1424-3903(18)30658-6.
Title: Silencing of TRPM8 inhibits aggressive tumor phenotypes and enhances gemcitabine sensitivity in pancreatic cancer.
Author: Liu, JieFeng|Hu, GuoHuang|Gong, YuJing|Yu, QianLe|He, Bin|Li, WangHao|He, ZhiGuo|Hao, WenJie|He, ZiChao|Liu, YiPing
PMID: 30316690