Primary Site >> Liver Cancer

Gene >> PTGS2

Journal: Hepatology. 1999 Mar;29(3):688-96.
Title: Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation.
Author: Koga, H|Sakisaka, S|Ohishi, M|Kawaguchi, T|Taniguchi, E|Sasatomi, K|Harada, M|Kusaba, T|Tanaka, M|Kimura, R|Nakashima, Y|Nakashima, O|Kojiro, M|Kurohiji, T|Sata, M
PMID: 10051469
Journal: World J Gastroenterol. 2001 Dec;7(6):796-800.
Title: Growth inhibition and apoptosis induction of Sulindac on Human gastric cancer cells.
Author: Wu, Y L|Sun, B|Zhang, X J|Wang, S N|He, H Y|Qiao, M M|Zhong, J|Xu, J Y
PMID: 11854904
Journal: Prostaglandins Leukot Essent Fatty Acids. 2003 Nov;69(5):329-37.
Title: Cyclooxygenase 2 (COX2)-prostanoid pathway and liver diseases.
Author: Hu, Ke-Qin
PMID: 14580367
Journal: Am J Pathol. 2006 Apr;168(4):1375-84.
Title: Epigenetic instability and chromosomal instability in hepatocellular carcinoma.
Author: Katoh, Hiroto|Shibata, Tatsuhiro|Kokubu, Akiko|Ojima, Hidenori|Fukayama, Masashi|Kanai, Yae|Hirohashi, Setsuo
PMID: 16565510
Journal: Exp Mol Med. 2006 Dec 31;38(6):694-702.
Title: Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance.
Author: Park, Byung Lae|Kim, Yoon Jun|Cheong, Hyun Sub|Kim, Lyoung Hyo|Choi, Yoo Hyun|Lee, Hyo-Suk|Shin, Hyoung Doo
PMID: 17202846
Journal: Environ Toxicol Pharmacol. 2007 Jan;23(1):89-95.
Title: Genotoxic activity and induction of biotransformation enzymes in two human cell lines after treatment by Erika fuel extract.
Author: Amat-Bronnert, Agnes|Castegnaro, Marcel|Pfohl-Leszkowicz, Annie
PMID: 21783741
Journal: Hepatology. 2008 Mar;47(3):908-18.
Title: Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma.
Author: Nishida, Naoshi|Nagasaka, Takeshi|Nishimura, Takafumi|Ikai, Iwao|Boland, C Richard|Goel, Ajay
PMID: 18161048
Journal: PLoS One. 2010 Apr 15;5(4):e10201.
Title: DEHP impairs zebrafish reproduction by affecting critical factors in oogenesis.
Author: Carnevali, Oliana|Tosti, Luca|Speciale, Claudia|Peng, Chun|Zhu, Yong|Maradonna, Francesca
PMID: 20419165
Journal: Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):308-13.
Title: Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver.
Author: Osterreicher, Christoph H|Penz-Osterreicher, Melitta|Grivennikov, Sergei I|Guma, Monica|Koltsova, Ekaterina K|Datz, Christian|Sasik, Roman|Hardiman, Gary|Karin, Michael|Brenner, David A
PMID: 21173249
Journal: Breast Cancer Res. 2011 Sep 13;13(5):R87.
Title: Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study.
Author: Sihto, Harri|Lundin, Johan|Lundin, Mikael|Lehtimaki, Tiina|Ristimaki, Ari|Holli, Kaija|Sailas, Liisa|Kataja, Vesa|Turpeenniemi-Hujanen, Taina|Isola, Jorma|Heikkila, Paivi|Joensuu, Heikki
PMID: 21914172
Journal: Biochem J. 2011 Apr 15;435(2):431-9.
Title: Endoplasmic reticulum stress induced by hepatitis B virus X protein enhances cyclo-oxygenase 2 expression via activating transcription factor 4.
Author: Cho, Hyun Kook|Cheong, Kyu Jin|Kim, Hye Young|Cheong, Jaehun
PMID: 21244365
Journal: J Hepatol. 2011 May;54(5):939-47.
Title: Aberrant CpG island hypermethylation in dysplastic nodules and early HCC of hepatitis B virus-related human multistep hepatocarcinogenesis.
Author: Um, Tae-Hee|Kim, Haeryoung|Oh, Bong-Kyeong|Kim, Myoung Soo|Kim, Kyung Sik|Jung, Guhung|Park, Young Nyun
PMID: 21145824
Journal: Biomed Pharmacother. 2012 Sep;66(6):454-8.
Title: Genes responsible for the characteristics of primary cultured invasive phenotype hepatocellular carcinoma cells.
Author: Lin, Zu-Yau|Chuang, Wan-Long
PMID: 22681909
Journal: Pathol Oncol Res. 2013 Jan;19(1):55-62.
Title: Immunosuppressive prednisolone enhances early cholangiocarcinoma in Syrian hamsters with liver fluke infection and administration of N-nitrosodimethylamine.
Author: Juasook, Amornrat|Boonmars, Thidarut|Wu, Zhiliang|Loilome, Watcharin|Veteewuthacharn, Kulathida|Namwat, Nissana|Sudsarn, Pakkayanee|Wonkchalee, Orasa|Sriraj, Pranee|Aukkanimart, Ratchadawan
PMID: 22851165
Journal: PLoS One. 2013 May 31;8(5):e65023.
Title: Aspirin minimized the pro-metastasis effect of sorafenib and improved survival by up-regulating HTATIP2 in hepatocellular carcinoma.
Author: Lu, Lu|Sun, Hui-Chuan|Zhang, Wei|Chai, Zong-Tao|Zhu, Xiao-Dong|Kong, Ling-Qun|Wang, Wen-Quan|Zhang, Ke-Zhi|Zhang, Yuan-Yuan|Zhang, Qiang-Bo|Ao, Jian-Yang|Li, Jia-Qi|Wang, Lu|Wu, Wei-Zhong|Tang, Zhao-You
PMID: 23741443
Journal: World J Gastroenterol. 2013 Oct 28;19(40):6883-7.
Title: Expression and significance of cyclooxygenase-2 mRNA in benign and malignant ascites.
Author: Lu, Jing|Li, Xiao-Feng|Kong, Li-Xia|Ma, Lin|Liao, Su-Huan|Jiang, Chang-You
PMID: 24187465
Journal: Mol Med Rep. 2014 Nov;10(5):2556-62.
Title: Saikosaponind suppresses the expression of cyclooxygenase2 through the phosphosignal transducer and activator of transcription 3/hypoxiainducible factor1alpha pathway in hepatocellular carcinoma cells.
Author: He, Shuixiang|Lu, Guifang|Hou, Helei|Zhao, Zhenjun|Zhu, Zhanfang|Lu, Xinlan|Chen, Jinghong|Wang, Zhilun
PMID: 25231214
Journal: Br J Cancer. 2014 Aug 12;111(4):749-55.
Title: Epidermal growth factor receptor (EGFR) and prostaglandin-endoperoxide synthase 2 (PTGS2) are prognostic biomarkers for patients with resected colorectal cancer liver metastases.
Author: Goos, J A C M|Hiemstra, A C|Coupe, V M H|Diosdado, B|Kooijman, W|Delis-Van Diemen, P M|Karga, C|Belien, J A M|Menke-van der Houven van Oordt, C W|Geldof, A A|Meijer, G A|Hoekstra, O S|Fijneman, R J A
PMID: 24983372
Journal: Onco Targets Ther. 2014 Feb 24;7:353-63.
Title: Cyclooxygenase-2 inhibitor is a robust enhancer of anticancer agents against hepatocellular carcinoma multicellular spheroids.
Author: Cui, Jie|Guo, Ya-Huan|Zhang, Hong-Yi|Jiang, Li-Li|Ma, Jie-Qun|Wang, Wen-Juan|Wang, Min-Cong|Yang, Cheng-Cheng|Nan, Ke-Jun|Song, Li-Ping
PMID: 24591842
Journal: Oncogene. 2014 Jun 5;33(23):2949-55.
Title: Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology.
Author: Ogino, S|Lochhead, P|Giovannucci, E|Meyerhardt, J A|Fuchs, C S|Chan, A T
PMID: 23792451
Journal: Eur J Gastroenterol Hepatol. 2014 Aug;26(8):871-9.
Title: Angiogenesis and proliferation markers in adjacent cirrhotic tissue could predict hepatocellular carcinoma outcome after liver transplantation.
Author: Campillo, Ana|Solanas, Estela|Morandeira, Maria J|Castiella, Tomas|Lorente, Sara|Garcia-Gil, Francisco Agustin|Piazuelo, Elena|de Martino, Alba|Serrano, Maria T
PMID: 24922356
Journal: PLoS Genet. 2015 Feb 18;11(2):e1004873.
Title: Systemic delivery of microRNA-101 potently inhibits hepatocellular carcinoma in vivo by repressing multiple targets.
Author: Zheng, Fang|Liao, Yi-Ji|Cai, Mu-Yan|Liu, Tian-Hao|Chen, Shu-Peng|Wu, Pei-Hong|Wu, Long|Bian, Xiu-Wu|Guan, Xin-Yuan|Zeng, Yi-Xin|Yuan, Yun-Fei|Kung, Hsiang-Fu|Xie, Dan
PMID: 25693145
Journal: J Clin Exp Hepatol. 2015 Mar;5(1):14-21.
Title: Study of the effects of cyclooxygenase-2 inhibitor on the promotion of hepatic tumorigenesis in rats fed a high fat diet.
Author: Hamzawy, Magda|Elsaid, Laila|Shams, Asmaa|Rashid, Laila|Mahfouz, Soheir|Sharawy, Nivin
PMID: 25941430
Journal: Mol Med Rep. 2015 Sep;12(3):4572-4577.
Title: Berberine induces apoptosis by suppressing the arachidonic acid metabolic pathway in hepatocellular carcinoma.
Author: Li, Jing|Li, Ou|Kan, Mujie|Zhang, Ming|Shao, Dan|Pan, Yue|Zheng, Huilin|Zhang, Xuewen|Chen, Li|Liu, Songyan
PMID: 26081696
Journal: J Cancer. 2015 Jun 25;6(8):740-9.
Title: Methylation Profiling of Multiple Tumor Suppressor Genes in Hepatocellular Carcinoma and the Epigenetic Mechanism of 3OST2 Regulation.
Author: Chen, Haiyan|Zhang, Tingguo|Sheng, Yan|Zhang, Cheng|Peng, Yunfei|Wang, Xiao|Zhang, Cuijuan
PMID: 26185536
Journal: Medicine (Baltimore). 2015 Sep;94(35):e1116.
Title: Common Variants of the Prostaglandin-Endoperoxide Synthase 2 Gene and Hepatocellular Carcinoma Susceptibility.
Author: Li, Hong-guang|Liu, Fang-feng|Zhu, Hua-qiang|Zhou, Xu|Lu, Jun|Chang, Hong|Hu, Jin-hua
PMID: 26334888
Journal: Am J Transl Res. 2015 Dec 15;7(12):2752-63. eCollection 2015.
Title: c9, t11- conjugated linoleic acid induces HCC cell apoptosis and correlation with PPAR-gamma signaling pathway.
Author: Lu, Guozhong|Zhang, Guoqing|Zheng, Xing|Zeng, Yan|Xu, Ziqi|Zeng, Weichi|Wang, Kebing
PMID: 26885272
Journal: Am J Transl Res. 2016 Feb 15;8(2):1064-72. eCollection 2016.
Title: IL-13 induces the expression of 11betaHSD2 in IL-13Ralpha2 dependent manner and promotes the malignancy of colorectal cancer.
Author: Jiang, Li|Cheng, Qi|Zhang, Binhao|Zhang, Mingzhi
PMID: 27158392
Journal: Mol Med Rep. 2016 Dec;14(6):5667-5676.
Title: Effect of ximenynic acid on cell cycle arrest and apoptosis and COX-1 in HepG2 cells.
Author: Cai, Fang|Li, Jianying|Liu, Yandi|Zhang, Zunyi|Hettiarachchi, D S|Li, Duo
PMID: 27840952
Journal: J Gastrointest Oncol. 2016 Aug;7(4):570-9.
Title: A genetic database can be utilized to identify potential biomarkers for biphenotypic hepatocellular carcinoma-cholangiocarcinoma.
Author: Mok, Shaffer R S|Mohan, Sachin|Grewal, Navjot|Elfant, Adam B|Judge, Thomas A
PMID: 27563447
Journal: Sci Rep. 2016 May 4;6:24944.
Title: Molecular targets of Chinese herbs: a clinical study of hepatoma based on network pharmacology.
Author: Gao, Li|Wang, Xiao-Dong|Niu, Yang-Yang|Duan, Dan-Dan|Yang, Xue|Hao, Jian|Zhu, Cui-Hong|Chen, Dan|Wang, Ke-Xin|Qin, Xue-Mei|Wu, Xiong-Zhi
PMID: 27143508
Journal: Oncotarget. 2016 Feb 23;7(8):8866-78.
Title: Activated hepatic stellate cells promote liver cancer by induction of myeloid-derived suppressor cells through cyclooxygenase-2.
Author: Xu, Yaping|Zhao, Wenxiu|Xu, Jianfeng|Li, Jie|Hong, Zaifa|Yin, Zhenyu|Wang, Xiaomin
PMID: 26758420
Journal: Cancer Discov. 2017 May;7(5):522-538.
Title: Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity.
Author: Loo, Tze Mun|Kamachi, Fumitaka|Watanabe, Yoshihiro|Yoshimoto, Shin|Kanda, Hiroaki|Arai, Yuriko|Nakajima-Takagi, Yaeko|Iwama, Atsushi|Koga, Tomoaki|Sugimoto, Yukihiko|Ozawa, Takayuki|Nakamura, Masaru|Kumagai, Miho|Watashi, Koichi|Taketo, Makoto M|Aoki, Tom
PMID: 28202625
Journal: Oncol Res. 2018 Jan 2.
Title: MiR-136 inhibits malignant progression of hepatocellular carcinoma cells by targeting cyclooxygenase 2.
Author: Jia, Haiyan|Wang, Hong|Yao, Yanfen|Wang, Chunlei|Li, Pibao
PMID: 29295728
Journal: Pathol Res Pract. 2018 Jun;214(6):914-918.
Title: Intrahepatic cholangiocarcinoma after Fontan procedure in an adult with visceral heterotaxy.
Author: Wang, Dehua|Marshall, Darren|Veldtman, Gruschen|Gupta, Anita|Trout, Andrew T|Villafane, Juan|Bove, Kevin
PMID: 29559246
Journal: Int J Mol Med. 2018 Aug;42(2):713-725.
Title: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review).
Author: Katoh, Masaru
PMID: 29786110
Journal: World J Gastroenterol. 2018 Jun 28;24(24):2605-2616.
Title: Bioinformatics analysis of aberrantly methylated-differentially expressed genes and pathways in hepatocellular carcinoma.
Author: Sang, Liang|Wang, Xue-Mei|Xu, Dong-Yang|Zhao, Wen-Jing
PMID: 29962817
Journal: Autophagy. 2018 Aug 21:1-21.
Title: Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells.
Author: Zhang, Zili|Yao, Zhen|Wang, Ling|Ding, Hai|Shao, Jiangjuan|Chen, Anping|Zhang, Feng|Zheng, Shizhong
PMID: 30081711
Journal: J Control Release. 2018 Oct 10;287:78-93.
Title: Dual-targeted casein micelles as green nanomedicine for synergistic phytotherapy of hepatocellular carcinoma.
Author: Abdelmoneem, Mona A|Mahmoud, Mazen|Zaky, Amira|Helmy, Maged W|Sallam, Marwa|Fang, Jia-You|Elkhodairy, Kadria A|Elzoghby, Ahmed O
PMID: 30138716
Journal: Int J Mol Med. 2018 Oct 16.
Title: COX-2 induces apoptosis-resistance in hepatocellular carcinoma cells via the HIF-1alpha/PKM2 pathway.
Author: Wang, Qin|Lu, Donghui|Fan, Lulu|Li, Yuhuan|Liu, Yu|Yu, Hanqing|Wang, Hua|Liu, Jiatao|Sun, Guoping
PMID: 30365092