Primary Site >> Colorectal Cancer

Gene >> PLK1

Journal: Curr Pharm Des. 2000 Mar;6(4):379-92.
Title: Cell cycle molecular targets in novel anticancer drug discovery.
Author: Buolamwini, J K
PMID: 10788588
Journal: Ann Surg Oncol. 2001 Oct;8(9):729-40.
Title: Comparative expression of the mitotic regulators SAK and PLK in colorectal cancer.
Author: Macmillan, J C|Hudson, J W|Bull, S|Dennis, J W|Swallow, C J
PMID: 11597015
Journal: Int J Oncol. 2002 Jan;20(1):121-6.
Title: Down-regulation of PLK3 gene expression by types and amount of dietary fat in rat colon tumors.
Author: Dai, Wei|Liu, Tongyi|Wang, Qi|Rao, Chinthalapally V|Reddy, Bandaru S
PMID: 11743651
Journal: Oncogene. 2002 May 9;21(20):3253-7.
Title: Gene expression differences between the microsatellite instability (MIN) and chromosomal instability (CIN) phenotypes in colorectal cancer revealed by high-density cDNA array hybridization.
Author: Dunican, Donncha S|McWilliam, Peter|Tighe, Orna|Parle-McDermott, Anne|Croke, David T
PMID: 12082642
Journal: J Natl Cancer Inst. 2002 Dec 18;94(24):1863-77.
Title: Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells.
Author: Spankuch-Schmitt, Birgit|Bereiter-Hahn, Jurgen|Kaufmann, Manfred|Strebhardt, Klaus
PMID: 12488480
Journal: Cancer Sci. 2003 Feb;94(2):148-52.
Title: Polo-like kinase 1 (PLK1) is overexpressed in primary colorectal cancers.
Author: Takahashi, Takao|Sano, Bun|Nagata, Takayasu|Kato, Hiroki|Sugiyama, Yasuyuki|Kunieda, Katsuyuki|Kimura, Masashi|Okano, Yukio|Saji, Shigetoyo
PMID: 12708489
Journal: J Biol Chem. 2004 May 14;279(20):21183-92.
Title: p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis.
Author: Kho, Patricia S|Wang, Zhen|Zhuang, Li|Li, Yuqing|Chew, Joon-Lin|Ng, Huck-Hui|Liu, Edison T|Yu, Qiang
PMID: 15016801
Journal: Oncogene. 2005 Jan 10;24(2):287-91.
Title: Polo-like kinases (Plks) and cancer.
Author: Takai, Noriyuki|Hamanaka, Ryoji|Yoshimatsu, Jun|Miyakawa, Isao
PMID: 15640844
Journal: World J Gastroenterol. 2005 Aug 7;11(29):4596-9.
Title: Apoptosis induction with polo-like kinase-1 antisense phosphorothioate oligodeoxynucleotide of colon cancer cell line SW480.
Author: Fan, Yu|Zheng, Shu|Xu, Ze-Feng|Ding, Jia-Yi
PMID: 16052696
Journal: World J Gastroenterol. 2005 Sep 28;11(36):5644-50.
Title: Polo-like kinase 1 expression is a prognostic factor in human colon cancer.
Author: Weichert, Wilko|Kristiansen, Glen|Schmidt, Mathias|Gekeler, Volker|Noske, Aurelia|Niesporek, Silvia|Dietel, Manfred|Denkert, Carsten
PMID: 16237758
Journal: Yi Chuan. 2006 Jan;28(1):21-5.
Title: [Knockdown of PLK1 mRNA by special siRNA].
Author: Chen, Gong-Xing|Dong, Qing-Hua|Zhang, Jia-Wei|Fu, Fang-Fang|Xu, Ze-Feng|Liang, Qiao-Yi|Zheng, Shu|Ding, Jia-Yi
PMID: 16469711
Journal: Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10747-52. Epub 2006 Jun 30.
Title: Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer.
Author: Hadjihannas, Michel V|Bruckner, Martina|Jerchow, Boris|Birchmeier, Walter|Dietmaier, Wolfgang|Behrens, Jurgen
PMID: 16815967
Journal: Radiat Oncol. 2006 Aug 3;1:25.
Title: Radiosensitization of colorectal carcinoma cell lines by histone deacetylase inhibition.
Author: Flatmark, Kjersti|Nome, Ragnhild V|Folkvord, Sigurd|Bratland, Ase|Rasmussen, Heidi|Ellefsen, Mali Strand|Fodstad, Oystein|Ree, Anne Hansen
PMID: 16887021
Journal: Clin Cancer Res. 2006 Sep 1;12(17):5182-9.
Title: A phase I pharmacokinetic study of HMN-214, a novel oral stilbene derivative with polo-like kinase-1-interacting properties, in patients with advanced solid tumors.
Author: Garland, Linda L|Taylor, Charles|Pilkington, Deborah L|Cohen, Jan L|Von Hoff, Daniel D
PMID: 16951237
Journal: Cancer Res. 2006 Nov 1;66(21):10349-56.
Title: Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c.
Author: Knock, Erin|Deng, Liyuan|Wu, Qing|Leclerc, Daniel|Wang, Xiao-ling|Rozen, Rima
PMID: 17079455
Journal: Genome Biol. 2007;8(7):R131.
Title: Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer.
Author: Kaiser, Sergio|Park, Young-Kyu|Franklin, Jeffrey L|Halberg, Richard B|Yu, Ming|Jessen, Walter J|Freudenberg, Johannes|Chen, Xiaodi|Haigis, Kevin|Jegga, Anil G|Kong, Sue|Sakthivel, Bhuvaneswari|Xu, Huan|Reichling, Timothy|Azhar, Mohammad|Boivin, Gregory P|
PMID: 17615082
Journal: Cell Cycle. 2007 Dec 15;6(24):3114-31.
Title: The cyclin-dependent kinase inhibitor seliciclib (R-roscovitine; CYC202) decreases the expression of mitotic control genes and prevents entry into mitosis.
Author: Whittaker, Steven R|Te Poele, Robert H|Chan, Florence|Linardopoulos, Spiros|Walton, Michael I|Garrett, Michelle D|Workman, Paul
PMID: 18075315
Journal: Curr Pharm Biotechnol. 2008 Dec;9(6):510-5.
Title: The database dbEST correctly predicts gene expression in colon cancer patients.
Author: Radeva, M|Hofmann, T|Altenberg, B|Mothes, H|Richter, K K|Pool-Zobel, B|Greulich, K O
PMID: 19075689
Journal: Mol Cell Proteomics. 2009 Apr;8(4):827-45.
Title: Discovery and scoring of protein interaction subnetworks discriminative of late stage human colon cancer.
Author: Nibbe, Rod K|Markowitz, Sanford|Myeroff, Lois|Ewing, Rob|Chance, Mark R
PMID: 19098285
Journal: Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3964-9.
Title: A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53.
Author: Sur, Surojit|Pagliarini, Raymond|Bunz, Fred|Rago, Carlo|Diaz, Luis A Jr|Kinzler, Kenneth W|Vogelstein, Bert|Papadopoulos, Nickolas
PMID: 19225112
Journal: Clin Cancer Res. 2009 May 1;15(9):3094-102.
Title: BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity.
Author: Rudolph, Dorothea|Steegmaier, Martin|Hoffmann, Matthias|Grauert, Matthias|Baum, Anke|Quant, Jens|Haslinger, Christian|Garin-Chesa, Pilar|Adolf, Gunther R
PMID: 19383823
Journal: Environ Mol Mutagen. 2009 Oct;50(8):672-96.
Title: Nucleation capacity and presence of centrioles define a distinct category of centrosome abnormalities that induces multipolar mitoses in cancer cells.
Author: Difilippantonio, Michael J|Ghadimi, B Michael|Howard, Tamara|Camps, Jordi|Nguyen, Quang Tri|Ferris, Douglas K|Sackett, Dan L|Ried, Thomas
PMID: 19768832
Journal: Am J Pathol. 2010 Aug;177(2):918-29.
Title: Polo-like kinase 1 as predictive marker and therapeutic target for radiotherapy in rectal cancer.
Author: Rodel, Franz|Keppner, Sarah|Capalbo, Gianni|Bashary, Robina|Kaufmann, Manfred|Rodel, Claus|Strebhardt, Klaus|Spankuch, Birgit
PMID: 20581060
Journal: Int J Cancer. 2011 Mar 1;128(5):1069-79.
Title: A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets.
Author: Grade, Marian|Hummon, Amanda B|Camps, Jordi|Emons, Georg|Spitzner, Melanie|Gaedcke, Jochen|Hoermann, Patrick|Ebner, Reinhard|Becker, Heinz|Difilippantonio, Michael J|Ghadimi, B Michael|Beissbarth, Tim|Caplen, Natasha J|Ried, Thomas
PMID: 20473941
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2011 Jan;14(1):61-4.
Title: [Influence of silencing Polo-like kinase 1 on migration and invasion of colorectal cancer cells].
Author: Han, Ding-Pei|Cui, Jiang-Tao|Lu, Ai-Guo|Chen, Xue-Hua|Feng, Bo|Zong, Ya-Ping|Qu, Shun|Cao, Qi-Feng|Zheng, Min-Hua
PMID: 21271384
Journal: Cancer Biother Radiopharm. 2011 Aug;26(4):427-36.
Title: Efficient inhibition of human colorectal carcinoma growth by RNA interference targeting polo-like kinase 1 in vitro and in vivo.
Author: Xu, Wen-Jing|Zhang, Shuang|Yang, Yang|Zhang, Na|Wang, Wei|Liu, Sheng-Yong|Tian, Hong-Wei|Dai, Lei|Xie, Qian|Zhao, Xia|Wei, Yu-Quan|Deng, Hong-Xin
PMID: 21797676
Journal: Exp Mol Pathol. 2012 Feb;92(1):27-32.
Title: Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population.
Author: Mori, Takashi|Nishizawa, Satoshi|Hirohashi, Yoshihiko|Torigoe, Toshihiko|Tamura, Yasuaki|Takahashi, Akari|Kochin, Vitaly|Fujii, Reona|Kondo, Toru|Greene, Mark I|Hara, Isao|Sato, Noriyuki
PMID: 22001602
Journal: Neoplasma. 2012;59(6):676-84.
Title: Enhanced chemosensitivity to CPT-11 in colorectal carcinoma xenografts by small hairpin RNA interference targeting PLK1.
Author: Fan, P|Zhang, S|Tian, H|Yan, N|Dai, L|Zhang, X|Cheng, L|Li, C|Li, Y|Chen, X|Shi, G|Yang, Y|Wei, Y|Deng, H
PMID: 22862168
Journal: Stem Cells. 2012 Sep;30(9):1819-30.
Title: Proliferation state and polo-like kinase1 dependence of tumorigenic colon cancer cells.
Author: Francescangeli, Federica|Patrizii, Michele|Signore, Michele|Federici, Giulia|Di Franco, Simone|Pagliuca, Alfredo|Baiocchi, Marta|Biffoni, Mauro|Ricci Vitiani, Lucia|Todaro, Matilde|De Maria, Ruggero|Zeuner, Ann
PMID: 22753241
Journal: Med Sci Monit. 2012 Jun;18(6):BR237-46.
Title: Polo-like kinase 1 is overexpressed in colorectal cancer and participates in the migration and invasion of colorectal cancer cells.
Author: Han, Ding-pei|Zhu, Qian-lin|Cui, Jiang-tao|Wang, Pu-xiongzhi|Qu, Shun|Cao, Qi-feng|Zong, Ya-ping|Feng, Bo|Zheng, Min-hua|Lu, Ai-guo
PMID: 22648245
Journal: Mol Cancer Ther. 2012 Mar;11(3):700-9.
Title: TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens.
Author: Hikichi, Yuichi|Honda, Kohei|Hikami, Kouki|Miyashita, Hitoshi|Kaieda, Isao|Murai, Saomi|Uchiyama, Noriko|Hasegawa, Maki|Kawamoto, Tomohiro|Sato, Takashi|Ichikawa, Takashi|Cao, Sheldon|Nie, Zhe|Zhang, Lilly|Yang, Johnny|Kuida, Keisuke|Kupperman, Erik
PMID: 22188812
Journal: J Med Chem. 2012 Jan 12;55(1):197-208.
Title: Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905).
Author: Duffey, Matthew O|Vos, Tricia J|Adams, Ruth|Alley, Jennifer|Anthony, Justin|Barrett, Cynthia|Bharathan, Indu|Bowman, Douglas|Bump, Nancy J|Chau, Ryan|Cullis, Courtney|Driscoll, Denise L|Elder, Amy|Forsyth, Nancy|Frazer, Jonathan|Guo, Jianping|Guo, Luyi|Hy
PMID: 22070629
Journal: Cell Cycle. 2012 Feb 1;11(3):543-53.
Title: p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors.
Author: Sanhaji, Mourad|Kreis, Nina-Naomi|Zimmer, Brigitte|Berg, Thorsten|Louwen, Frank|Yuan, Juping
PMID: 22262171
Journal: Cancer Biol Ther. 2013 May;14(5):436-49.
Title: Identification of novel compounds that enhance colon cancer cell sensitivity to inflammatory apoptotic ligands.
Author: Chopra, Avijeet S|Kuratnik, Anton|Scocchera, Eric W|Wright, Dennis L|Giardina, Charles
PMID: 23377828
Journal: Cell Div. 2013 May 16;8(1):7.
Title: Cell cycle-dependent localization of CHK2 at centrosomes during mitosis.
Author: Chouinard, Guillaume|Clement, Isabelle|Lafontaine, Julie|Rodier, Francis|Schmitt, Estelle
PMID: 23680298
Journal: Cancer Discov. 2013 Oct;3(10):1156-71.
Title: PDK1 signaling toward PLK1-MYC activation confers oncogenic transformation, tumor-initiating cell activation, and resistance to mTOR-targeted therapy.
Author: Tan, Jing|Li, Zhimei|Lee, Puay Leng|Guan, Peiyong|Aau, Mei Yee|Lee, Shuet Theng|Feng, Min|Lim, Cheryl Zihui|Lee, Eric Yong Jing|Wee, Zhen Ning|Lim, Yaw Chyn|Karuturi, R K Murthy|Yu, Qiang
PMID: 23887393
Journal: J Proteome Res. 2013 Sep 6;12(9):4136-51.
Title: TIMP-1 increases expression and phosphorylation of proteins associated with drug resistance in breast cancer cells.
Author: Hekmat, Omid|Munk, Stephanie|Fogh, Louise|Yadav, Rachita|Francavilla, Chiara|Horn, Heiko|Wurtz, Sidse Ornbjerg|Schrohl, Anne-Sofie|Damsgaard, Britt|Romer, Maria Unni|Belling, Kirstine C|Jensen, Niels Frank|Gromova, Irina|Bekker-Jensen, Dorte B|Moreira, Jo
PMID: 23909892
Journal: Int J Biomater. 2013;2013:252531.
Title: Systemic siRNA Delivery via Peptide-Tagged Polymeric Nanoparticles, Targeting PLK1 Gene in a Mouse Xenograft Model of Colorectal Cancer.
Author: Malhotra, Meenakshi|Tomaro-Duchesneau, Catherine|Saha, Shyamali|Prakash, Satya
PMID: 24159333
Journal: Radiother Oncol. 2014 Feb;110(2):355-61.
Title: PLK1-inhibition can cause radiosensitization or radioresistance dependent on the treatment schedule.
Author: Lund-Andersen, Christin|Patzke, Sebastian|Nahse-Kumpf, Viola|Syljuasen, Randi G
PMID: 24502970
Journal: Dis Markers. 2014;2014:798170.
Title: Expression of the microtubule-associated protein MAP9/ASAP and its partners AURKA and PLK1 in colorectal and breast cancers.
Author: Rouquier, Sylvie|Pillaire, Marie-Jeanne|Cazaux, Christophe|Giorgi, Dominique
PMID: 24876664
Journal: PLoS One. 2015 Jun 5;10(6):e0129313.
Title: Upregulated Polo-Like Kinase 1 Expression Correlates with Inferior Survival Outcomes in Rectal Cancer.
Author: Tut, T G|Lim, S H S|Dissanayake, I U|Descallar, J|Chua, W|Ng, W|de Souza, P|Shin, J-S|Lee, C S
PMID: 26047016
Journal: Nat Chem Biol. 2015 Jan;11(1):58-63.
Title: GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors.
Author: Thorne, Curtis A|Wichaidit, Chonlarat|Coster, Adam D|Posner, Bruce A|Wu, Lani F|Altschuler, Steven J
PMID: 25402767
Journal: Pathol Oncol Res. 2016 Apr;22(2):377-83.
Title: PLK-1 Expression is Associated with Histopathological Response to Neoadjuvant Therapy of Hepatic Metastasis of Colorectal Carcinoma.
Author: Fernandez-Acenero, M J|Cortes, D|Gomez del Pulgar, T|Cebrian, A|Estrada, L|Martinez-Useros, J|Celdran, A|Garcia-Foncillas, J|Pastor, C
PMID: 26577686
Journal: Tumour Biol. 2016 Nov;37(11):14415-14425.
Title: Study of apoptosis-related interactions in colorectal cancer.
Author: Arora, Himanshu|Qureshi, Rehana|Rizvi, M A|Shrivastava, Sharad|Parihar, Mordhwaj S
PMID: 27629291
Journal: Cancer Sci. 2016 Dec;107(12):1877-1887.
Title: Effect of AKT3 expression on MYC- and caspase-8-dependent apoptosis caused by polo-like kinase inhibitors in HCT 116 cells.
Author: Nonomiya, Yuma|Noguchi, Kohji|Tanaka, Noritaka|Kasagaki, Takahiro|Katayama, Kazuhiro|Sugimoto, Yoshikazu
PMID: 27699933
Journal: Pathol Res Pract. 2016 Dec;212(12):1133-1137.
Title: Decreased PLK1 expression denotes therapy resistance and unfavourable disease-free survival in rectal cancer patients receiving neoadjuvant chemoradiotherapy.
Author: Cebrian, Arancha|Gomez Del Pulgar, Teresa|Fernandez-Acenero, Maria Jesus|Borrero-Palacios, Aurea|Del Puerto-Nevado, Laura|Martinez-Useros, Javier|Marin-Arango, Juan Pablo|Carames, Cristina|Vega-Bravo, Ricardo|Rodriguez-Remirez, Maria|Manzarbeitia, Felix|G
PMID: 27712975
Journal: Cancer Sci. 2017 May;108(5):1042-1048.
Title: YPC-21661 and YPC-22026, novel small molecules, inhibit ZNF143 activity in vitro and in vivo.
Author: Haibara, Hirotaka|Yamazaki, Ryuta|Nishiyama, Yukiko|Ono, Masahiro|Kobayashi, Tsuneyuki|Hokkyo-Itagaki, Atsuko|Nishisaka, Fukiko|Nishiyama, Hiroyuki|Kurita, Akinobu|Matsuzaki, Takeshi|Izumi, Hiroto|Kohno, Kimitoshi
PMID: 28192620
Journal: Biochim Biophys Acta Gen Subj. 2017 Jul;1861(7):1777-1787.
Title: Polo-like kinase 1 expression is suppressed by CCAAT/enhancer-binding protein alpha to mediate colon carcinoma cell differentiation and apoptosis.
Author: Dasgupta, Nirmalya|Thakur, Bhupesh Kumar|Ta, Atri|Das, Sayan|Banik, George|Das, Santasabuj
PMID: 28341486
Journal: World J Stem Cells. 2017 May 26;9(5):77-88.
Title: Next-generation sequencing traces human induced pluripotent stem cell lines clonally generated from heterogeneous cancer tissue.
Author: Ishikawa, Tetsuya
PMID: 28596815
Journal: Br J Pharmacol. 2018 Mar;175(5):743-762.
Title: Simultaneous use of erythropoietin and LFM-A13 as a new therapeutic approach for colorectal cancer.
Author: Tankiewicz-Kwedlo, Anna|Hermanowicz, Justyna Magdalena|Domaniewski, Tomasz|Pawlak, Krystyna|Rusak, Malgorzata|Pryczynicz, Anna|Surazynski, Arkadiusz|Kaminski, Tomasz|Kazberuk, Adam|Pawlak, Dariusz
PMID: 29160911
Journal: BMC Cancer. 2018 Feb 5;18(1):136.
Title: Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer.
Author: Klauck, Peter J|Bagby, Stacey M|Capasso, Anna|Bradshaw-Pierce, Erica L|Selby, Heather M|Spreafico, Anna|Tentler, John J|Tan, Aik Choon|Kim, Jihye|Arcaroli, John J|Purkey, Alicia|Messersmith, Wells A|Kuida, Keisuke|Eckhardt, S Gail|Pitts, Todd M
PMID: 29402316
Journal: Nat Commun. 2018 Mar 16;9(1):1106.
Title: PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells.
Author: Raab, Monika|Sanhaji, Mourad|Matthess, Yves|Horlin, Albrecht|Lorenz, Ioana|Dotsch, Christina|Habbe, Nils|Waidmann, Oliver|Kurunci-Csacsko, Elisabeth|Firestein, Ron|Becker, Sven|Strebhardt, Klaus
PMID: 29549256
Journal: Theranostics. 2018 Apr 15;8(10):2884-2895.
Title: G9a stimulates CRC growth by inducing p53 Lys373 dimethylation-dependent activation of Plk1.
Author: Zhang, Jie|Wang, Yafang|Shen, Yanyan|He, Pengxing|Ding, Jian|Chen, Yi
PMID: 29774081