Literatures

Primary Site >> Colorectal Cancer

Gene >> PIK3CA

1.
Journal:	J Biol Chem. 1998 Nov 27;273(48):32016-22.
Title:	A novel mitogenic signaling pathway of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, phosphatidylinositol 3-kinase beta, and protein kinase Cepsilon.
Author:	Graness, A\|Adomeit, A\|Heinze, R\|Wetzker, R\|Liebmann, C
PMID:	9822674

2.
Journal:	Oncogene. 2000 Oct 19;19(44):5083-90.
Title:	A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells.
Author:	Benistant, C\|Chapuis, H\|Roche, S
PMID:	11042696

3.
Journal:	FASEB J. 2000 Nov;14(14):2329-38.
Title:	Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways.
Author:	Attoub, S\|Noe, V\|Pirola, L\|Bruyneel, E\|Chastre, E\|Mareel, M\|Wymann, M P\|Gespach, C
PMID:	11053255

4.
Journal:	Gut. 2003 Oct;52(10):1472-8.
Title:	Phosphatidylinositol 3-kinase mediates proliferative signals in intestinal epithelial cells.
Author:	Sheng, H\|Shao, J\|Townsend, C M Jr\|Evers, B M
PMID:	12970141

5.
Journal:	Carcinogenesis. 2004 Feb;25(2):241-8.
Title:	Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma.
Author:	Khaleghpour, Kianoush\|Li, Yang\|Banville, Denis\|Yu, Zhenbao\|Shen, Shi-Hsiang
PMID:	14578160

6.
Journal:	Cancer Res. 2004 Aug 1;64(15):5048-50.
Title:	Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas.
Author:	Broderick, Daniel K\|Di, Chunhui\|Parrett, Timothy J\|Samuels, Yardena R\|Cummins, Jordan M\|McLendon, Roger E\|Fults, Daniel W\|Velculescu, Victor E\|Bigner, Darell D\|Yan, Hai
PMID:	15289301

7.
Journal:	Surgery. 2004 Aug;136(2):143-9.
Title:	Inhibition of alpha5 integrin decreases PI3K activation and cell adhesion of human colon cancers.
Author:	Murillo, Carlos A\|Rychahou, Piotr G\|Evers, B Mark
PMID:	15300173

8.
Journal:	Cancer Res. 2004 Nov 1;64(21):7678-81.
Title:	Mutation of the PIK3CA gene in ovarian and breast cancer.
Author:	Campbell, Ian G\|Russell, Sarah E\|Choong, David Y H\|Montgomery, Karen G\|Ciavarella, Marianne L\|Hooi, Christine S F\|Cristiano, Briony E\|Pearson, Richard B\|Phillips, Wayne A
PMID:	15520168

9.
Journal:	Oncogene. 2005 Feb 17;24(8):1477-80.
Title:	PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.
Author:	Lee, Jong Woo\|Soung, Young Hwa\|Kim, Su Young\|Lee, Hae Woo\|Park, Won Sang\|Nam, Suk Woo\|Kim, Sang Ho\|Lee, Jung Young\|Yoo, Nam Jin\|Lee, Sug Hyung
PMID:	15608678

10.
Journal:	Cell Physiol Biochem. 2005;15(1-4):29-40.
Title:	TNF-alpha activates MUC2 transcription via NF-kappaB but inhibits via JNK activation.
Author:	Ahn, Dae-ho\|Crawley, Suzanne C\|Hokari, Ryota\|Kato, Shingo\|Yang, Stacey C\|Li, Jian-Dong\|Kim, Young S
PMID:	15665513

11.
Journal:	Lancet Oncol. 2005 May;6(5):279-86.
Title:	Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study.
Author:	Moroni, Mauro\|Veronese, Silvio\|Benvenuti, Silvia\|Marrapese, Giovanna\|Sartore-Bianchi, Andrea\|Di Nicolantonio, Federica\|Gambacorta, Marcello\|Siena, Salvatore\|Bardelli, Alberto
PMID:	15863375

12.
Journal:	Cancer Res. 2005 Jun 1;65(11):4562-7.
Title:	Functional analysis of PIK3CA gene mutations in human colorectal cancer.
Author:	Ikenoue, Tsuneo\|Kanai, Fumihiko\|Hikiba, Yohko\|Obata, Toshiyuki\|Tanaka, Yasuo\|Imamura, Jun\|Ohta, Miki\|Jazag, Amarsanaa\|Guleng, Bayasi\|Tateishi, Keisuke\|Asaoka, Yoshinari\|Matsumura, Masayuki\|Kawabe, Takao\|Omata, Masao
PMID:	15930273

13.
Journal:	Cancer Cell. 2005 Jun;7(6):561-73.
Title:	Mutant PIK3CA promotes cell growth and invasion of human cancer cells.
Author:	Samuels, Yardena\|Diaz, Luis A Jr\|Schmidt-Kittler, Oleg\|Cummins, Jordan M\|Delong, Laura\|Cheong, Ian\|Rago, Carlo\|Huso, David L\|Lengauer, Christoph\|Kinzler, Kenneth W\|Vogelstein, Bert\|Velculescu, Victor E
PMID:	15950905

14.
Journal:	Eur J Cancer. 2005 Jul;41(11):1649-54.
Title:	The prevalence of PIK3CA mutations in gastric and colon cancer.
Author:	Velho, Sergia\|Oliveira, Carla\|Ferreira, Ana\|Ferreira, Antonio Carlos\|Suriano, Gianpaolo\|Schwartz, Simo Jr\|Duval, Alex\|Carneiro, Fatima\|Machado, Jose Carlos\|Hamelin, Richard\|Seruca, Raquel
PMID:	15994075

15.
Journal:	FEBS Lett. 2005 Sep 26;579(23):5123-8.
Title:	Comparison of phosphatidylinositol-3-kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA.
Author:	Morrow, Christopher J\|Gray, Alexander\|Dive, Caroline
PMID:	16150444

16.
Journal:	Breast Cancer Res. 2005;7(5):R609-16.
Title:	Somatic mutation and gain of copy number of PIK3CA in human breast cancer.
Author:	Wu, Guojun\|Xing, Mingzhao\|Mambo, Elizabeth\|Huang, Xin\|Liu, Junwei\|Guo, Zhongmin\|Chatterjee, Aditi\|Goldenberg, David\|Gollin, Susanne M\|Sukumar, Saraswati\|Trink, Barry\|Sidransky, David
PMID:	16168105

17.
Journal:	Int J Cancer. 2006 Mar 15;118(6):1426-9.
Title:	Somatic mutations of the ERBB4 kinase domain in human cancers.
Author:	Soung, Young Hwa\|Lee, Jong Woo\|Kim, Su Young\|Wang, Young Pil\|Jo, Keon Hyun\|Moon, Seok Whan\|Park, Won Sang\|Nam, Suk Woo\|Lee, Jung Young\|Yoo, Nam Jin\|Lee, Sug Hyung
PMID:	16187281

18.
Journal:	Curr Opin Oncol. 2006 Jan;18(1):77-82.
Title:	Oncogenic PI3K and its role in cancer.
Author:	Samuels, Yardena\|Ericson, Kajsa
PMID:	16357568

19.
Journal:	Biochem Biophys Res Commun. 2006 Feb 10;340(2):469-75. Epub 2005 Dec 15.
Title:	Correlation of PIK3Ca mutations with gene expression and drug sensitivity in NCI-60 cell lines.
Author:	Whyte, David B\|Holbeck, Susan L
PMID:	16376301

20.
Journal:	Clin Cancer Res. 2006 Jan 1;12(1):57-61.
Title:	Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.
Author:	Lee, Jong Woo\|Soung, Young Hwa\|Seo, Si Hyung\|Kim, Su Young\|Park, Cho Hyun\|Wang, Young Pil\|Park, Kyeongmee\|Nam, Suk Woo\|Park, Won Sang\|Kim, Sang Ho\|Lee, Jung Young\|Yoo, Nam Jin\|Lee, Sug Hyung
PMID:	16397024

21.
Journal:	J Biol Chem. 2006 May 19;281(20):13957-63. Epub 2006 Mar 16.
Title:	Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc.
Author:	Mizukami, Yusuke\|Fujiki, Kotoyo\|Duerr, Eva-Maria\|Gala, Manish\|Jo, Won-Seok\|Zhang, Xiaobo\|Chung, Daniel C
PMID:	16543245

22.
Journal:	Cancer Res. 2006 Apr 15;66(8):3992-5.
Title:	KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.
Author:	Lievre, Astrid\|Bachet, Jean-Baptiste\|Le Corre, Delphine\|Boige, Valerie\|Landi, Bruno\|Emile, Jean-Francois\|Cote, Jean-Francois\|Tomasic, Gorana\|Penna, Christophe\|Ducreux, Michel\|Rougier, Philippe\|Penault-Llorca, Frederique\|Laurent-Puig, Pierre
PMID:	16618717

23.
Journal:	Ann Surg. 2006 Jun;243(6):833-42; discussion 843-4.
Title:	Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma.
Author:	Rychahou, Piotr G\|Jackson, Lindsey N\|Silva, Scott R\|Rajaraman, Srinivasan\|Evers, B Mark
PMID:	16772787

24.
Journal:	Clin Chem. 2006 Dec;52(12):2299-302.
Title:	Improved marker combination for detection of de novo genetic variation and aberrant DNA in colorectal neoplasia.
Author:	Kann, Lisa\|Han, James\|Ahlquist, David\|Levin, Theodore\|Rex, Douglas\|Whitney, Duncan\|Markowitz, Sanford\|Shuber, Anthony
PMID:	17082247

25.
Journal:	Mol Cancer Res. 2007 Feb;5(2):195-201.
Title:	Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines.
Author:	Hollestelle, Antoinette\|Elstrodt, Fons\|Nagel, Jord H A\|Kallemeijn, Wouter W\|Schutte, Mieke
PMID:	17314276

26.
Journal:	Mol Cancer Ther. 2007 Mar;6(3):1143-50.
Title:	Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis.
Author:	Wang, Jing\|Kuropatwinski, Karen\|Hauser, Jennie\|Rossi, Michael R\|Zhou, Yunfei\|Conway, Alexis\|Kan, Julie L C\|Gibson, Neil W\|Willson, James K V\|Cowell, John K\|Brattain, Michael G
PMID:	17363507

27.
Journal:	Int J Cancer. 2007 Oct 1;121(7):1627-30.
Title:	Mutations of the PIK3CA gene in hereditary colorectal cancers.
Author:	Miyaki, Michiko\|Iijima, Takeru\|Yamaguchi, Tatsuro\|Takahashi, Keiichi\|Matsumoto, Hiroshi\|Yasutome, Michiya\|Funata, Nobuaki\|Mori, Takeo
PMID:	17546593

28.
Journal:	Cancer Res. 2007 Jun 15;67(12):5851-8.
Title:	Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model.
Author:	Guo, Xiao-Ning\|Rajput, Ashwani\|Rose, Rebecca\|Hauser, Jennie\|Beko, Alexander\|Kuropatwinski, Karen\|LeVea, Charles\|Hoffman, Robert M\|Brattain, Michael G\|Wang, Jing
PMID:	17575153

29.
Journal:	Int J Cancer. 2007 Oct 15;121(8):1771-8.
Title:	PIK3CA mutation is predictive of poor survival in patients with colorectal cancer.
Author:	Kato, Shunsuke\|Iida, Satoru\|Higuchi, Tetsuro\|Ishikawa, Toshiaki\|Takagi, Yoko\|Yasuno, Masamichi\|Enomoto, Masayuki\|Uetake, Hiroyuki\|Sugihara, Kenichi
PMID:	17590872

30.
Journal:	Int J Cancer. 2008 Mar 1;122(5):1189-94.
Title:	Novel mutant-enriched sequencing identified high frequency of PIK3CA mutations in pharyngeal cancer.
Author:	Qiu, Wanglong\|Tong, Guo-Xia\|Manolidis, Spiros\|Close, Lanny G\|Assaad, Adel M\|Su, Gloria H
PMID:	17990317

31.
Journal:	Hum Mutat. 2008 Feb;29(2):284-8.
Title:	PIK3CA cancer mutations display gender and tissue specificity patterns.
Author:	Benvenuti, Silvia\|Frattini, Milo\|Arena, Sabrina\|Zanon, Carlo\|Cappelletti, Vera\|Coradini, Danila\|Daidone, Maria Grazia\|Pilotti, Silvana\|Pierotti, Marco A\|Bardelli, Alberto
PMID:	18022911

32.
Journal:	J Cell Physiol. 2008 May;215(2):538-49.
Title:	Deoxycholyltaurine rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling.
Author:	Raufman, Jean-Pierre\|Shant, Jasleen\|Guo, Chang Yue\|Roy, Sanjit\|Cheng, Kunrong
PMID:	18064605

33.
Journal:	Oncogene. 2008 Jun 5;27(25):3539-45.
Title:	Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population.
Author:	Abubaker, J\|Bavi, P\|Al-Harbi, S\|Ibrahim, M\|Siraj, A K\|Al-Sanea, N\|Abduljabbar, A\|Ashari, L H\|Alhomoud, S\|Al-Dayel, F\|Uddin, S\|Al-Kuraya, K S
PMID:	18193083

34.
Journal:	Cancer Res. 2008 Mar 15;68(6):1953-61.
Title:	PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab.
Author:	Jhawer, Minaxi\|Goel, Sanjay\|Wilson, Andrew J\|Montagna, Cristina\|Ling, Yi-He\|Byun, Do-Sun\|Nasser, Shannon\|Arango, Diego\|Shin, Joongho\|Klampfer, Lidija\|Augenlicht, Leonard H\|Perez-Soler, Roman\|Mariadason, John M
PMID:	18339877

35.
Journal:	Clin Chem. 2008 Apr;54(4):757-60.
Title:	Multiplexed assays for detection of mutations in PIK3CA.
Author:	Board, Ruth E\|Thelwell, Nicola J\|Ravetto, Paul F\|Little, Stephen\|Ranson, Malcolm\|Dive, Caroline\|Hughes, Andrew\|Whitcombe, David
PMID:	18375489

36.
Journal:	Carcinogenesis. 2008 Jun;29(6):1087-91.
Title:	Defining the blueprint of the cancer genome.
Author:	Velculescu, Victor E
PMID:	18495658

37.
Journal:	Neoplasia. 2008 Jun;10(6):534-41.
Title:	PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations.
Author:	Nosho, Katsuhiko\|Kawasaki, Takako\|Ohnishi, Mutsuko\|Suemoto, Yuko\|Kirkner, Gregory J\|Zepf, Dimity\|Yan, Liying\|Longtine, Janina A\|Fuchs, Charles S\|Ogino, Shuji
PMID:	18516290

38.
Journal:	Mol Cancer Ther. 2008 Jun;7(6):1337-46.
Title:	In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation.
Author:	Ikediobi, Ogechi N\|Reimers, Mark\|Durinck, Steffen\|Blower, Paul E\|Futreal, Andrew P\|Stratton, Michael R\|Weinstein, John N
PMID:	18524847

39.
Journal:	Hum Pathol. 2008 Sep;39(9):1301-8.
Title:	Genetic alterations in colorectal cancers with demethylation of insulin-like growth factor II.
Author:	Ohta, Miki\|Sugimoto, Takafumi\|Seto, Motoko\|Mohri, Dai\|Asaoka, Yoshinari\|Tada, Motohisa\|Tanaka, Yasuo\|Yamaji, Yutaka\|Kanai, Fumihiko\|Kawabe, Takao\|Omata, Masao
PMID:	18619647

40.
Journal:	Am J Clin Pathol. 2008 Aug;130(2):247-53.
Title:	High-resolution melting analysis for rapid detection of KRAS, BRAF, and PIK3CA gene mutations in colorectal cancer.
Author:	Simi, Lisa\|Pratesi, Nicola\|Vignoli, Marina\|Sestini, Roberta\|Cianchi, Fabio\|Valanzano, Rosa\|Nobili, Stefania\|Mini, Enrico\|Pazzagli, Mario\|Orlando, Claudio
PMID:	18628094

41.
Journal:	Cell Cycle. 2008 Sep 1;7(17):2674-81.
Title:	Somatic oncogenic mutations, benign skin lesions and cancer progression: where to look next?
Author:	Toll, Agusti\|Real, Francisco X
PMID:	18728396

42.
Journal:	Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13057-62.
Title:	PTEN-deficient cancers depend on PIK3CB.
Author:	Wee, Susan\|Wiederschain, Dmitri\|Maira, Sauveur-Michel\|Loo, Alice\|Miller, Christine\|deBeaumont, Rosalie\|Stegmeier, Frank\|Yao, Yung-Mae\|Lengauer, Christoph
PMID:	18755892

43.
Journal:	BMC Cancer. 2008 Sep 9;8:255.
Title:	BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?
Author:	Velho, Sergia\|Moutinho, Catia\|Cirnes, Luis\|Albuquerque, Cristina\|Hamelin, Richard\|Schmitt, Fernando\|Carneiro, Fatima\|Oliveira, Carla\|Seruca, Raquel
PMID:	18782444

44.
Journal:	Ann N Y Acad Sci. 2008 Sep;1138:204-13.
Title:	The transforming functions of PI3-kinase-gamma are linked to disruption of intercellular adhesion and promotion of cancer cell invasion.
Author:	Attoub, Samir\|De Wever, Olivier\|Bruyneel, Eric\|Mareel, Marc\|Gespach, Christian
PMID:	18837901

45.
Journal:	Cancer Genet Cytogenet. 2008 Dec;187(2):74-9.
Title:	PIK3CA gene mutations in breast carcinoma in Malaysian patients.
Author:	Ching-Shian Leong, Vincent\|Jabal, Mohd Faizal\|Leong, Pooi Pooi\|Abdullah, Maizaton Atmadini\|Gul, Yunus Alif\|Seow, Heng Fong
PMID:	19027487

46.
Journal:	J Clin Pathol. 2009 Sep;62(9):777-85.
Title:	Molecular pathology of endometrial carcinoma: practical aspects from the diagnostic and therapeutic viewpoints.
Author:	Llobet, D\|Pallares, J\|Yeramian, A\|Santacana, M\|Eritja, N\|Velasco, A\|Dolcet, X\|Matias-Guiu, X
PMID:	18977806

47.
Journal:	Cancer Lett. 2009 Feb 18;274(2):266-70.
Title:	Endometrial cancer and somatic G>T KRAS transversion in patients with constitutional MUTYH biallelic mutations.
Author:	Tricarico, Rossella\|Bet, Paola\|Ciambotti, Benedetta\|Di Gregorio, Carmela\|Gatteschi, Beatrice\|Gismondi, Viviana\|Toschi, Benedetta\|Tonelli, Francesco\|Varesco, Liliana\|Genuardi, Maurizio
PMID:	18980800

48.
Journal:	Am J Surg Pathol. 2009 Apr;33(4):572-82.
Title:	Clinical, pathologic, and molecular features of early-onset colorectal carcinoma.
Author:	Yantiss, Rhonda K\|Goodarzi, Mahmoud\|Zhou, Xi K\|Rennert, Hanna\|Pirog, Edyta C\|Banner, Barbara F\|Chen, Yao-Tseng
PMID:	19047896

49.
Journal:	Neoplasia. 2009 Jan;11(1):87-95.
Title:	JC virus T-antigen in colorectal cancer is associated with p53 expression and chromosomal instability, independent of CpG island methylator phenotype.
Author:	Nosho, Katsuhiko\|Shima, Kaori\|Kure, Shoko\|Irahara, Natsumi\|Baba, Yoshifumi\|Chen, Li\|Kirkner, Gregory J\|Fuchs, Charles S\|Ogino, Shuji
PMID:	19107235

50.
Journal:	Gastroenterology. 2009 Apr;136(4):1242-50.
Title:	Colorectal cancer expression of peroxisome proliferator-activated receptor gamma (PPARG, PPARgamma) is associated with good prognosis.
Author:	Ogino, Shuji\|Shima, Kaori\|Baba, Yoshifumi\|Nosho, Katsuhiko\|Irahara, Natsumi\|Kure, Shoko\|Chen, Li\|Toyoda, Saori\|Kirkner, Gregory J\|Wang, Y Lynn\|Giovannucci, Edward L\|Fuchs, Charles S
PMID:	19186181

51.
Journal:	Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2835-40.
Title:	Knockin of mutant PIK3CA activates multiple oncogenic pathways.
Author:	Gustin, John P\|Karakas, Bedri\|Weiss, Michele B\|Abukhdeir, Abde M\|Lauring, Josh\|Garay, Joseph P\|Cosgrove, David\|Tamaki, Akina\|Konishi, Hiroyuki\|Konishi, Yuko\|Mohseni, Morassa\|Wang, Grace\|Rosen, D Marc\|Denmeade, Samuel R\|Higgins, Michaela J\|Vitolo, Michele
PMID:	19196980

52.
Journal:	Cancer Res. 2009 Mar 1;69(5):1851-7.
Title:	PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies.
Author:	Sartore-Bianchi, Andrea\|Martini, Miriam\|Molinari, Francesca\|Veronese, Silvio\|Nichelatti, Michele\|Artale, Salvatore\|Di Nicolantonio, Federica\|Saletti, Piercarlo\|De Dosso, Sara\|Mazzucchelli, Luca\|Frattini, Milo\|Siena, Salvatore\|Bardelli, Alberto
PMID:	19223544

53.
Journal:	J Biol Chem. 2009 Apr 17;284(16):10912-22.
Title:	Knockdown of Ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma.
Author:	Wang, Jing\|Rajput, Ashwani\|Kan, Julie L C\|Rose, Rebecca\|Liu, Xiao-Qiong\|Kuropatwinski, Karen\|Hauser, Jennie\|Beko, Alexander\|Dominquez, Ivan\|Sharratt, Elizabeth A\|Brattain, Lisa\|Levea, Charles\|Sun, Feng-Lei\|Keane, David M\|Gibson, Neil W\|Brattain, Michael G
PMID:	19224914

54.
Journal:	J Clin Oncol. 2009 Mar 20;27(9):1477-84.
Title:	PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer.
Author:	Ogino, Shuji\|Nosho, Katsuhiko\|Kirkner, Gregory J\|Shima, Kaori\|Irahara, Natsumi\|Kure, Shoko\|Chan, Andrew T\|Engelman, Jeffrey A\|Kraft, Peter\|Cantley, Lewis C\|Giovannucci, Edward L\|Fuchs, Charles S
PMID:	19237633

55.
Journal:	Neoplasia. 2009 May;11(5):418-25.
Title:	Aurora-A expression is independently associated with chromosomal instability in colorectal cancer.
Author:	Baba, Yoshifumi\|Nosho, Katsuhiko\|Shima, Kaori\|Irahara, Natsumi\|Kure, Shoko\|Toyoda, Saori\|Kirkner, Gregory J\|Goel, Ajay\|Fuchs, Charles S\|Ogino, Shuji
PMID:	19412426

56.
Journal:	Mod Pathol. 2009 Jul;22(7):922-32.
Title:	SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
Author:	Nosho, Katsuhiko\|Shima, Kaori\|Irahara, Natsumi\|Kure, Shoko\|Firestein, Ron\|Baba, Yoshifumi\|Toyoda, Saori\|Chen, Li\|Hazra, Aditi\|Giovannucci, Edward L\|Fuchs, Charles S\|Ogino, Shuji
PMID:	19430421

57.
Journal:	Clin Cancer Res. 2009 Jun 1;15(11):3663-71.
Title:	DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer.
Author:	Nosho, Katsuhiko\|Shima, Kaori\|Irahara, Natsumi\|Kure, Shoko\|Baba, Yoshifumi\|Kirkner, Gregory J\|Chen, Li\|Gokhale, Sumita\|Hazra, Aditi\|Spiegelman, Donna\|Giovannucci, Edward L\|Jaenisch, Rudolf\|Fuchs, Charles S\|Ogino, Shuji
PMID:	19470733

58.
Journal:	PLoS One. 2009 May 27;4(5):e5717.
Title:	Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors.
Author:	Jaiswal, Bijay S\|Janakiraman, Vasantharajan\|Kljavin, Noelyn M\|Eastham-Anderson, Jeffrey\|Cupp, James E\|Liang, Yuxin\|Davis, David P\|Hoeflich, Klaus P\|Seshagiri, Somasekar
PMID:	19492075

59.
Journal:	Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1849-58.
Title:	A cohort study of p27 localization in colon cancer, body mass index, and patient survival.
Author:	Ogino, Shuji\|Shima, Kaori\|Nosho, Katsuhiko\|Irahara, Natsumi\|Baba, Yoshifumi\|Wolpin, Brian M\|Giovannucci, Edward L\|Meyerhardt, Jeffrey A\|Fuchs, Charles S
PMID:	19505918

60.
Journal:	Mol Cancer Res. 2009 Jun;7(6):955-65.
Title:	Blocking phosphoinositide 3-kinase activity in colorectal cancer cells reduces proliferation but does not increase apoptosis alone or in combination with cytotoxic drugs.
Author:	Martin-Fernandez, Cristina\|Bales, Juliana\|Hodgkinson, Cassandra\|Welman, Arkadiusz\|Welham, Melanie J\|Dive, Caroline\|Morrow, Christopher J
PMID:	19509113

61.
Journal:	Am J Gastroenterol. 2009 Aug;104(8):2047-56.
Title:	A cohort study of STMN1 expression in colorectal cancer: body mass index and prognosis.
Author:	Ogino, Shuji\|Nosho, Katsuhiko\|Baba, Yoshifumi\|Kure, Shoko\|Shima, Kaori\|Irahara, Natsumi\|Toyoda, Saori\|Chen, Li\|Kirkner, Gregory J\|Wolpin, Brian M\|Chan, Andrew T\|Giovannucci, Edward L\|Fuchs, Charles S
PMID:	19513025

62.
Journal:	Mol Diagn Ther. 2009;13(2):103-14.
Title:	Clinical biomarkers in oncology: focus on colorectal cancer.
Author:	De Roock, Wendy\|Biesmans, Bart\|De Schutter, Jef\|Tejpar, Sabine
PMID:	19537845

63.
Journal:	Clin Cancer Res. 2009 Jul 15;15(14):4665-73.
Title:	Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer.
Author:	Baba, Yoshifumi\|Nosho, Katsuhiko\|Shima, Kaori\|Freed, Ellen\|Irahara, Natsumi\|Philips, Juliet\|Meyerhardt, Jeffrey A\|Hornick, Jason L\|Shivdasani, Ramesh A\|Fuchs, Charles S\|Ogino, Shuji
PMID:	19584150

64.
Journal:	Gan To Kagaku Ryoho. 2009 Jul;36(7):1063-6.
Title:	[Status of components in EGFR-related signal transduction as predictive markers for anti-EGFR antibody therapy in colorectal cancer treatment].
Author:	Shimodaira, Hideki\|Soeda, Hiroshi\|Komine, Keigo\|Ishioka, Chikashi
PMID:	19620792

65.
Journal:	Gastroenterology. 2009 Nov;137(5):1609-20.e1-3.
Title:	A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers.
Author:	Nosho, Katsuhiko\|Kure, Shoko\|Irahara, Natsumi\|Shima, Kaori\|Baba, Yoshifumi\|Spiegelman, Donna\|Meyerhardt, Jeffrey A\|Giovannucci, Edward L\|Fuchs, Charles S\|Ogino, Shuji
PMID:	19686742

66.
Journal:	J Pathol. 2009 Nov;219(3):337-46.
Title:	Frequent PIK3CA gene amplification and its clinical significance in colorectal cancer.
Author:	Jehan, Zeenath\|Bavi, Prashant\|Sultana, Mehar\|Abubaker, Jehad\|Bu, Rong\|Hussain, Azhar\|Alsbeih, Ghazi\|Al-Sanea, Nasser\|Abduljabbar, Alaa\|Ashari, Luai H\|Alhomoud, Samar\|Al-Dayel, Fouad\|Uddin, Shahab\|Al-Kuraya, Khawla S
PMID:	19697359

67.
Journal:	J Clin Oncol. 2009 Sep 20;27(27):4591-8.
Title:	Prognostic significance and molecular associations of 18q loss of heterozygosity: a cohort study of microsatellite stable colorectal cancers.
Author:	Ogino, Shuji\|Nosho, Katsuhiko\|Irahara, Natsumi\|Shima, Kaori\|Baba, Yoshifumi\|Kirkner, Gregory J\|Meyerhardt, Jeffrey A\|Fuchs, Charles S
PMID:	19704056

68.
Journal:	Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2513-21.
Title:	p21 expression in colon cancer and modifying effects of patient age and body mass index on prognosis.
Author:	Ogino, Shuji\|Nosho, Katsuhiko\|Shima, Kaori\|Baba, Yoshifumi\|Irahara, Natsumi\|Kirkner, Gregory J\|Hazra, Aditi\|De Vivo, Immaculata\|Giovannucci, Edward L\|Meyerhardt, Jeffrey A\|Fuchs, Charles S
PMID:	19723919

69.
Journal:	J Natl Cancer Inst. 2009 Oct 7;101(19):1308-24.
Title:	Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer.
Author:	Siena, Salvatore\|Sartore-Bianchi, Andrea\|Di Nicolantonio, Federica\|Balfour, Julia\|Bardelli, Alberto
PMID:	19738166

70.
Journal:	Cancer Res. 2009 Oct 1;69(19):7811-8.
Title:	An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression.
Author:	Yuan, Ziqiang\|Shin, Joongho\|Wilson, Andrew\|Goel, Sanjay\|Ling, Yi-He\|Ahmed, Naseem\|Dopeso, Higinio\|Jhawer, Minaxi\|Nasser, Shannon\|Montagna, Cristina\|Fordyce, Kenneth\|Augenlicht, Leonard H\|Aaltonen, Lauri A\|Arango, Diego\|Weber, Thomas K\|Mariadason, John M
PMID:	19789347

71.
Journal:	Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2765-72.
Title:	Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer.
Author:	Kure, Shoko\|Nosho, Katsuhiko\|Baba, Yoshifumi\|Irahara, Natsumi\|Shima, Kaori\|Ng, Kimmie\|Meyerhardt, Jeffrey A\|Giovannucci, Edward L\|Fuchs, Charles S\|Ogino, Shuji
PMID:	19789368

72.
Journal:	PLoS One. 2009 Oct 2;4(10):e7287.
Title:	Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer.
Author:	Sartore-Bianchi, Andrea\|Di Nicolantonio, Federica\|Nichelatti, Michele\|Molinari, Francesca\|De Dosso, Sara\|Saletti, Piercarlo\|Martini, Miriam\|Cipani, Tiziana\|Marrapese, Giovanna\|Mazzucchelli, Luca\|Lamba, Simona\|Veronese, Silvio\|Frattini, Milo\|Bardelli, Albe
PMID:	19806185

73.
Journal:	Clin Cancer Res. 2009 Nov 15;15(22):6956-62.
Title:	PIK3CA mutations predict local recurrences in rectal cancer patients.
Author:	He, Youji\|Van't Veer, Laura J\|Mikolajewska-Hanclich, Izabela\|van Velthuysen, Marie-Louise F\|Zeestraten, Eliane C M\|Nagtegaal, Iris D\|van de Velde, Cornelis J H\|Marijnen, Corrie A M
PMID:	19903786

74.
Journal:	Clin Cancer Res. 2009 Nov 15;15(22):6748-50.
Title:	Getting knit-PI3Ky: PIK3CA mutation status to direct multimodality therapy?
Author:	Myers, Andrea P\|Meyerhardt, Jeffrey A\|Cantley, Lewis C
PMID:	19903790

75.
Journal:	Clin Transl Oncol. 2009 Nov;11(11):737-47.
Title:	Biomarkers and anti-EGFR therapies for KRAS wild-type metastatic colorectal cancer.
Author:	Garcia-Saenz, Jose A\|Sastre, Javier\|Diaz-Rubio Garcia, Eduardo
PMID:	19917537

76.
Journal:	Cancer Cell. 2009 Dec 8;16(6):463-74.
Title:	Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation.
Author:	Jaiswal, Bijay S\|Janakiraman, Vasantharajan\|Kljavin, Noelyn M\|Chaudhuri, Subhra\|Stern, Howard M\|Wang, Weiru\|Kan, Zhengyan\|Dbouk, Hashem A\|Peters, Brock A\|Waring, Paul\|Dela Vega, Trisha\|Kenski, Denise M\|Bowman, Krista K\|Lorenzo, Maria\|Li, Hong\|Wu, Jianshen
PMID:	19962665

77.
Journal:	Oncology. 2009;77 Suppl 1:69-74.
Title:	The dark side of the moon: the PI3K/PTEN/AKT pathway in colorectal carcinoma.
Author:	Silvestris, Nicola\|Tommasi, Stefania\|Petriella, Daniela\|Santini, Daniele\|Fistola, Ettore\|Russo, Antonio\|Numico, Gianmauro\|Tonini, Giuseppe\|Maiello, Evaristo\|Colucci, Giuseppe
PMID:	20130434

78.
Journal:	An R Acad Nac Med (Madr). 2009;126(2):243-57; discussion 258-62.
Title:	[Biomarkers and anti-EGFR therapies for KRAS wild-type tumors in metastatic colorectal cancer patients].
Author:	Diaz-Rubio Garcia, Eduardo
PMID:	20432670

79.
Journal:	Fam Cancer. 2010 Jun;9(2):125-9.
Title:	Frequent alterations of the PI3K/AKT/mTOR pathways in hereditary nonpolyposis colorectal cancer.
Author:	Ekstrand, Anna Isinger\|Jonsson, Mats\|Lindblom, Annika\|Borg, Ake\|Nilbert, Mef
PMID:	19731079

80.
Journal:	Int J Cancer. 2010 Jun 15;126(12):2863-73.
Title:	CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival.
Author:	Firestein, Ron\|Shima, Kaori\|Nosho, Katsuhiko\|Irahara, Natsumi\|Baba, Yoshifumi\|Bojarski, Emeric\|Giovannucci, Edward L\|Hahn, William C\|Fuchs, Charles S\|Ogino, Shuji
PMID:	19790197

81.
Journal:	Cancer Epidemiol Biomarkers Prev. 2010 Jan;19(1):301-9.
Title:	Cytoplasmic localization of beta-catenin is a marker of poor outcome in breast cancer patients.
Author:	Lopez-Knowles, Elena\|Zardawi, Sarah J\|McNeil, Catriona M\|Millar, Ewan K A\|Crea, Paul\|Musgrove, Elizabeth A\|Sutherland, Robert L\|O'Toole, Sandra A
PMID:	20056651

82.
Journal:	PLoS One. 2010 Jan 21;5(1):e8802.
Title:	Two multiplex assays that simultaneously identify 22 possible mutation sites in the KRAS, BRAF, NRAS and PIK3CA genes.
Author:	Lurkin, Irene\|Stoehr, Robert\|Hurst, Carolyn D\|van Tilborg, Angela A G\|Knowles, Margaret A\|Hartmann, Arndt\|Zwarthoff, Ellen C
PMID:	20098682

83.
Journal:	J Clin Oncol. 2010 Mar 1;28(7):1254-61.
Title:	Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer.
Author:	Bardelli, Alberto\|Siena, Salvatore
PMID:	20100961

84.
Journal:	Clin Cancer Res. 2010 Feb 1;16(3):790-9.
Title:	Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases.
Author:	Baldus, Stephan E\|Schaefer, Karl-L\|Engers, Rainer\|Hartleb, Dinah\|Stoecklein, Nikolas H\|Gabbert, Helmut E
PMID:	20103678

85.
Journal:	Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):822-31.
Title:	PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype.
Author:	Baba, Yoshifumi\|Nosho, Katsuhiko\|Shima, Kaori\|Goessling, Wolfram\|Chan, Andrew T\|Ng, Kimmie\|Chan, Jennifer A\|Giovannucci, Edward L\|Fuchs, Charles S\|Ogino, Shuji
PMID:	20200425

86.
Journal:	BMC Cancer. 2010 Mar 16;10:101.
Title:	A rapid, sensitive, reproducible and cost-effective method for mutation profiling of colon cancer and metastatic lymph nodes.
Author:	Fumagalli, Debora\|Gavin, Patrick G\|Taniyama, Yusuke\|Kim, Seung-Il\|Choi, Hyun-Joo\|Paik, Soonmyung\|Pogue-Geile, Katherine L
PMID:	20233444

87.
Journal:	Am J Pathol. 2010 May;176(5):2292-301.
Title:	HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers.
Author:	Baba, Yoshifumi\|Nosho, Katsuhiko\|Shima, Kaori\|Irahara, Natsumi\|Chan, Andrew T\|Meyerhardt, Jeffrey A\|Chung, Daniel C\|Giovannucci, Edward L\|Fuchs, Charles S\|Ogino, Shuji
PMID:	20363910

88.
Journal:	Oncogene. 2010 May 27;29(21):3033-43.
Title:	Oncogenic mutations as predictive factors in colorectal cancer.
Author:	Lievre, A\|Blons, H\|Laurent-Puig, P
PMID:	20383189

89.
Journal:	Eur J Cancer. 2010 Jul;46(11):1997-2009.
Title:	Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab.
Author:	Tol, Jolien\|Dijkstra, Jeroen R\|Klomp, Marjolein\|Teerenstra, Steven\|Dommerholt, Martin\|Vink-Borger, M Elisa\|van Cleef, Patricia H\|van Krieken, J Han\|Punt, Cornelis J A\|Nagtegaal, Iris D
PMID:	20413299

90.
Journal:	Recent Pat DNA Gene Seq. 2010 Jun;4(2):86-93.
Title:	Recent patents and advances in genomic biomarker discovery for colorectal cancers.
Author:	Quyun, Chen\|Ye, Zhiyun\|Lin, Sheng-Cai\|Lin, Biaoyang
PMID:	20426761

91.
Journal:	Mol Cancer. 2010 May 27;9:125.
Title:	Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors.
Author:	Baba, Yoshifumi\|Huttenhower, Curtis\|Nosho, Katsuhiko\|Tanaka, Noriko\|Shima, Kaori\|Hazra, Aditi\|Schernhammer, Eva S\|Hunter, David J\|Giovannucci, Edward L\|Fuchs, Charles S\|Ogino, Shuji
PMID:	20507599

92.
Journal:	J Biol Chem. 2010 Aug 6;285(32):24987-98.
Title:	Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1.
Author:	Larson, Yan\|Liu, Jianyu\|Stevens, Payton D\|Li, Xin\|Li, Jing\|Evers, B Mark\|Gao, Tianyan
PMID:	20530489

93.
Journal:	Cancer Res. 2010 Jul 1;70(13):5507-17.
Title:	The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy.
Author:	Al-Saffar, Nada M S\|Jackson, L Elizabeth\|Raynaud, Florence I\|Clarke, Paul A\|Ramirez de Molina, Ana\|Lacal, Juan C\|Workman, Paul\|Leach, Martin O
PMID:	20551061

94.
Journal:	Carcinogenesis. 2010 Sep;31(9):1604-11.
Title:	Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.
Author:	Slattery, Martha L\|Herrick, Jennifer S\|Lundgreen, Abbie\|Fitzpatrick, Francis A\|Curtin, Karen\|Wolff, Roger K
PMID:	20622004

95.
Journal:	Anat Rec (Hoboken). 2010 Sep;293(9):1506-11.
Title:	Gene mutations in epidermal growth factor receptor signaling network and their association with survival in Chinese patients with metastatic colorectal cancers.
Author:	Liao, Wangjun\|Liao, Yulin\|Zhou, Jeff X\|Xie, Jianming\|Chen, Jinzhang\|Huang, Weizhen\|Luo, Rongcheng
PMID:	20652941

96.
Journal:	Gastroenterology. 2010 Dec;139(6):1855-64.
Title:	Hypomethylation of the IGF2 DMR in colorectal tumors, detected by bisulfite pyrosequencing, is associated with poor prognosis.
Author:	Baba, Yoshifumi\|Nosho, Katsuhiko\|Shima, Kaori\|Huttenhower, Curtis\|Tanaka, Noriko\|Hazra, Aditi\|Giovannucci, Edward L\|Fuchs, Charles S\|Ogino, Shuji
PMID:	20682317

97.
Journal:	J Clin Oncol. 2010 Sep 20;28(27):4240-6.
Title:	Randomized, phase II study of the insulin-like growth factor-1 receptor inhibitor IMC-A12, with or without cetuximab, in patients with cetuximab- or panitumumab-refractory metastatic colorectal cancer.
Author:	Reidy, Diane Lauren\|Vakiani, Efsevia\|Fakih, Marwan G\|Saif, Muhammad Wasif\|Hecht, Joel Randolph\|Goodman-Davis, Noah\|Hollywood, Ellen\|Shia, Jinru\|Schwartz, Jonathan\|Chandrawansa, Kumari\|Dontabhaktuni, Aruna\|Youssoufian, Hagop\|Solit, David B\|Saltz, Leonard B
PMID:	20713879

98.
Journal:	Curr Cancer Drug Targets. 2010 Dec;10(8):813-23.
Title:	KRAS mutation testing of colorectal cancer for anti-EGFR therapy: dogmas versus evidence.
Author:	Timar, Jozsef\|Hegedus, Balazs\|Raso, Erzsebet
PMID:	20718705

99.
Journal:	Diagn Mol Pathol. 2010 Sep;19(3):157-63.
Title:	NRAS mutations are rare in colorectal cancer.
Author:	Irahara, Natsumi\|Baba, Yoshifumi\|Nosho, Katsuhiko\|Shima, Kaori\|Yan, Liying\|Dias-Santagata, Dora\|Iafrate, Anthony John\|Fuchs, Charles S\|Haigis, Kevin M\|Ogino, Shuji
PMID:	20736745

100.
Journal:	Br J Cancer. 2010 Sep 28;103(7):1025-33.
Title:	Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer.
Author:	Baba, Y\|Nosho, K\|Shima, K\|Meyerhardt, J A\|Chan, A T\|Engelman, J A\|Cantley, L C\|Loda, M\|Giovannucci, E\|Fuchs, C S\|Ogino, S
PMID:	20808308

101.
Journal:	Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2777-85.
Title:	Cathepsin B expression and survival in colon cancer: implications for molecular detection of neoplasia.
Author:	Chan, Andrew T\|Baba, Yoshifumi\|Shima, Kaori\|Nosho, Katsuhiko\|Chung, Daniel C\|Hung, Kenneth E\|Mahmood, Umar\|Madden, Karen\|Poss, Kirtland\|Ranieri, Audrey\|Shue, Daniel\|Kucherlapati, Raju\|Fuchs, Charles S\|Ogino, Shuji
PMID:	20833970

102.
Journal:	J Pathol. 2010 Dec;222(4):350-66.
Title:	Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review.
Author:	Nosho, Katsuhiko\|Baba, Yoshifumi\|Tanaka, Noriko\|Shima, Kaori\|Hayashi, Marika\|Meyerhardt, Jeffrey A\|Giovannucci, Edward\|Dranoff, Glenn\|Fuchs, Charles S\|Ogino, Shuji
PMID:	20927778

103.
Journal:	Expert Rev Gastroenterol Hepatol. 2010 Oct;4(5):525-9.
Title:	Colorectal cancer: cetuximab, KRAS, BRAF, PIK3CA mutations and beyond.
Author:	Katsios, Christos\|Ziogas, Dimosthenis E\|Roukos, Dimitrios H
PMID:	20932136

104.
Journal:	Mediators Inflamm. 2010;2010.
Title:	The p110alpha and p110beta isoforms of class I phosphatidylinositol 3-kinase are involved in toll-like receptor 5 signaling in epithelial cells.
Author:	Ivison, Sabine M\|Khan, Mohammed A S\|Graham, Nicholas R\|Shobab, Leila A\|Yao, Yu\|Kifayet, Arnawaz\|Sly, Laura M\|Steiner, Theodore S
PMID:	20953381

105.
Journal:	J Cell Biochem. 2010 Dec 1;111(5):1082-6.
Title:	Activation of signal pathways and the resistance to anti-EGFR treatment in colorectal cancer.
Author:	Chen, Jiezhong\|Huang, Xu-Feng\|Katsifis, Andrew
PMID:	21053280

106.
Journal:	PLoS One. 2010 Nov 12;5(11):e13978.
Title:	DNA sequence profiles of the colorectal cancer critical gene set KRAS-BRAF-PIK3CA-PTEN-TP53 related to age at disease onset.
Author:	Berg, Marianne\|Danielsen, Stine A\|Ahlquist, Terje\|Merok, Marianne A\|Agesen, Trude H\|Vatn, Morten H\|Mala, Tom\|Sjo, Ole H\|Bakka, Arne\|Moberg, Ingvild\|Fetveit, Torunn\|Mathisen, Oystein\|Husby, Anders\|Sandvik, Oddvar\|Nesbakken, Arild\|Thiis-Evensen, Espen\|Lothe
PMID:	21103049

107.
Journal:	Br J Cancer. 2010 Dec 7;103(12):1765-72.
Title:	Molecular determinants of anti-EGFR sensitivity and resistance in metastatic colorectal cancer.
Author:	Di Fiore, F\|Sesboue, R\|Michel, P\|Sabourin, J C\|Frebourg, T
PMID:	21139621

108.
Journal:	Magy Onkol. 2010 Dec;54(4):383-94.
Title:	Predictive and prognostic factors in the complex treatment of patients with colorectal cancer.
Author:	Laszlo, Landherr
PMID:	21163770

109.
Journal:	Clin Cancer Res. 2010 Dec 15;16(24):6179.
Title:	Do rectal cancer patients with PIK3CA mutations benefit from preoperative radiotherapy with regard to local recurrences?
Author:	He, Youji\|Van't Veer, Laura J\|Lopez-Yurda, Marta\|van de Velde, Cornelis J H\|Marijnen, Corrie A M
PMID:	21169263

110.
Journal:	Int J Cancer. 2011 Mar 1;128(5):1080-94.
Title:	Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review.
Author:	Shima, Kaori\|Nosho, Katsuhiko\|Baba, Yoshifumi\|Cantor, Mami\|Meyerhardt, Jeffrey A\|Giovannucci, Edward L\|Fuchs, Charles S\|Ogino, Shuji
PMID:	20473920

111.
Journal:	Mol Biol Rep. 2011 Feb;38(2):1347-51.
Title:	PIK3CA mutations in KRAS and BRAF wild type colorectal cancer patients. A study of Spanish population.
Author:	Herreros-Villanueva, Marta\|Gomez-Manero, Noemi\|Muniz, Pilar\|Garcia-Giron, Carlos\|Coma del Corral, Maria Jesus
PMID:	20571907

112.
Journal:	Mutat Res. 2011 Jan 10;706(1-2):13-20.
Title:	Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer.
Author:	Slattery, Martha L\|Lundgreen, Abbie\|Herrick, Jennifer S\|Wolff, Roger K
PMID:	21035469

113.
Journal:	Gut. 2011 Mar;60(3):397-411.
Title:	Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field.
Author:	Ogino, Shuji\|Chan, Andrew T\|Fuchs, Charles S\|Giovannucci, Edward
PMID:	21036793

114.
Journal:	Cancer Causes Control. 2011 Feb;22(2):301-9.
Title:	MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers.
Author:	Shima, Kaori\|Morikawa, Teppei\|Baba, Yoshifumi\|Nosho, Katsuhiko\|Suzuki, Maiko\|Yamauchi, Mai\|Hayashi, Marika\|Giovannucci, Edward\|Fuchs, Charles S\|Ogino, Shuji
PMID:	21140203

115.
Journal:	Lancet Oncol. 2011 Jun;12(6):594-603.
Title:	KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer.
Author:	De Roock, Wendy\|De Vriendt, Veerle\|Normanno, Nicola\|Ciardiello, Fortunato\|Tejpar, Sabine
PMID:	21163703

116.
Journal:	Oncol Rep. 2011 Mar;25(3):789-94.
Title:	Effect of classification based on combination of mutation and methylation in colorectal cancer prognosis.
Author:	Aoyagi, Haruhiko\|Iida, Satoru\|Uetake, Hiroyuki\|Ishikawa, Toshiaki\|Takagi, Yoko\|Kobayashi, Hirotoshi\|Higuchi, Tetsuro\|Yasuno, Masamichi\|Enomoto, Masayuki\|Sugihara, Kenichi
PMID:	21174064

117.
Journal:	Mol Cancer Ther. 2011 Mar;10(3):558-65.
Title:	PIK3CA mutations in patients with advanced cancers treated with PI3K/AKT/mTOR axis inhibitors.
Author:	Janku, Filip\|Tsimberidou, Apostolia M\|Garrido-Laguna, Ignacio\|Wang, Xuemei\|Luthra, Rajyalakshmi\|Hong, David S\|Naing, Aung\|Falchook, Gerald S\|Moroney, John W\|Piha-Paul, Sarina A\|Wheler, Jennifer J\|Moulder, Stacy L\|Fu, Siqing\|Kurzrock, Razelle
PMID:	21216929

118.
Journal:	Clin Cancer Res. 2011 Mar 1;17(5):1122-30.
Title:	KRAS mutation is associated with lung metastasis in patients with curatively resected colorectal cancer.
Author:	Tie, Jeanne\|Lipton, Lara\|Desai, Jayesh\|Gibbs, Peter\|Jorissen, Robert N\|Christie, Michael\|Drummond, Katharine J\|Thomson, Benjamin N J\|Usatoff, Valery\|Evans, Peter M\|Pick, Adrian W\|Knight, Simon\|Carne, Peter W G\|Berry, Roger\|Polglase, Adrian\|McMurrick, Paul
PMID:	21239505

119.
Journal:	PLoS One. 2011 Jan 20;6(1):e15980.
Title:	Impact of KRAS, BRAF, PIK3CA mutations, PTEN, AREG, EREG expression and skin rash in >/= 2 line cetuximab-based therapy of colorectal cancer patients.
Author:	Saridaki, Zacharenia\|Tzardi, Maria\|Papadaki, Chara\|Sfakianaki, Maria\|Pega, Fraga\|Kalikaki, Aristea\|Tsakalaki, Eleftheria\|Trypaki, Maria\|Messaritakis, Ippokratis\|Stathopoulos, Efstathios\|Mavroudis, Dimitris\|Georgoulias, Vassilis\|Souglakos, John
PMID:	21283802

120.
Journal:	Cancer Genomics Proteomics. 2011 Jan-Feb;8(1):15-8.
Title:	BRAF p.Val600Glu (V600E) somatic mutation is mainly associated with MSS phenotype in metastatic colorectal cancer.
Author:	Qiu, Jinghua\|Compagnone, Marion\|Laibe, Sophy\|Lagarde, Arnaud\|Goncalves, Anthony\|Turrini, Olivier\|Xerri, Luc\|Monges, Genevieve\|Olschwang, Sylviane
PMID:	21289333

121.
Journal:	Clin Cancer Res. 2011 Mar 15;17(6):1452-62.
Title:	STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers.
Author:	Morikawa, Teppei\|Baba, Yoshifumi\|Yamauchi, Mai\|Kuchiba, Aya\|Nosho, Katsuhiko\|Shima, Kaori\|Tanaka, Noriko\|Huttenhower, Curtis\|Frank, David A\|Fuchs, Charles S\|Ogino, Shuji
PMID:	21310826

122.
Journal:	J Gastroenterol Hepatol. 2011 Mar;26(3):599-607.
Title:	Analysis of K-ras, BRAF, and PIK3CA mutations in laterally-spreading tumors of the colorectum.
Author:	Kaji, Eisuke\|Kato, Jun\|Suzuki, Hideyuki\|Akita, Mitsuhiro\|Horii, Joichiro\|Saito, Shunsuke\|Higashi, Reiji\|Ishikawa, Shin\|Kuriyama, Motoaki\|Hiraoka, Sakiko\|Uraoka, Toshio\|Yamamoto, Kazuhide
PMID:	21332555

123.
Journal:	Oncol Rep. 2011 Jun;25(6):1691-7.
Title:	KRAS, BRAF and PIK3CA mutations in human colorectal cancer: relationship with metastatic colorectal cancer.
Author:	Li, Hong-Tao\|Lu, Yuan-Yuan\|An, Yan-Xin\|Wang, Xin\|Zhao, Qing-Chuan
PMID:	21424126

124.
Journal:	Cancer. 2011 Apr 1;117(7):1399-408.
Title:	Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers.
Author:	Baba, Yoshifumi\|Nosho, Katsuhiko\|Shima, Kaori\|Hayashi, Marika\|Meyerhardt, Jeffrey A\|Chan, Andrew T\|Giovannucci, Edward\|Fuchs, Charles S\|Ogino, Shuji
PMID:	21425139

125.
Journal:	Cancer J. 2011 Mar-Apr;17(2):114-26.
Title:	Molecular predictors of response to chemotherapy in colorectal cancer.
Author:	Dienstmann, Rodrigo\|Vilar, Eduardo\|Tabernero, Josep
PMID:	21427555

126.
Journal:	JAMA. 2011 Apr 27;305(16):1685-94.
Title:	Association of CTNNB1 (beta-catenin) alterations, body mass index, and physical activity with survival in patients with colorectal cancer.
Author:	Morikawa, Teppei\|Kuchiba, Aya\|Yamauchi, Mai\|Meyerhardt, Jeffrey A\|Shima, Kaori\|Nosho, Katsuhiko\|Chan, Andrew T\|Giovannucci, Edward\|Fuchs, Charles S\|Ogino, Shuji
PMID:	21521850

127.
Journal:	Clin Cancer Res. 2011 Jun 1;17(11):3551-7.
Title:	Detection of tumor DNA at the margins of colorectal cancer liver metastasis.
Author:	Holdhoff, Matthias\|Schmidt, Kerstin\|Diehl, Frank\|Aggrawal, Nishant\|Angenendt, Philipp\|Romans, Katharine\|Edelstein, Daniel L\|Torbenson, Michael\|Kinzler, Kenneth W\|Vogelstein, Bert\|Choti, Michael A\|Diaz, Luis A Jr
PMID:	21531819

128.
Journal:	Clin Cancer Res. 2011 Jul 15;17(14):4901-14.
Title:	Increased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer.
Author:	Molinari, Francesca\|Felicioni, Lara\|Buscarino, Michela\|De Dosso, Sara\|Buttitta, Fiamma\|Malatesta, Sara\|Movilia, Alessandra\|Luoni, Marco\|Boldorini, Renzo\|Alabiso, Oscar\|Girlando, Salvatore\|Soini, Barbara\|Spitale, Alessandra\|Di Nicolantonio, Federica\|Salett
PMID:	21632860

129.
Journal:	J Surg Oncol. 2011 Nov 1;104(6):661-6.
Title:	The status of EGFR-associated genes could predict the outcome and tumor response of chemo-refractory metastatic colorectal patients using cetuximab and chemotherapy.
Author:	Lin, Jen-Kou\|Lin, An-Jen\|Lin, Chun-Chi\|Lan, Yuan-Tzu\|Yang, Shung-Haur\|Li, Anna Fen-Yau\|Chang, Shih-Ching
PMID:	21671463

130.
Journal:	Mol Cancer Ther. 2011 Aug;10(8):1394-406.
Title:	Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin.
Author:	Bhagwat, Shripad V\|Gokhale, Prafulla C\|Crew, Andrew P\|Cooke, Andy\|Yao, Yan\|Mantis, Christine\|Kahler, Jennifer\|Workman, Jennifer\|Bittner, Mark\|Dudkin, Lorina\|Epstein, David M\|Gibson, Neil W\|Wild, Robert\|Arnold, Lee D\|Houghton, Peter J\|Pachter, Jonathan A
PMID:	21673091

131.
Journal:	Br J Cancer. 2011 Jul 12;105(2):281-7.
Title:	Molecular alterations associated with liver metastases development in colorectal cancer patients.
Author:	Bruin, S C\|He, Y\|Mikolajewska-Hanclich, I\|Liefers, G-J\|Klijn, C\|Vincent, A\|Verwaal, V J\|de Groot, K A\|Morreau, H\|van Velthuysen, M-L F\|Tollenaar, R A E M\|van 't Veer, L J
PMID:	21673680

132.
Journal:	J Mol Diagn. 2011 Jul;13(4):436-45.
Title:	KRAS, NRAS, PIK3CA exon 20, and BRAF genotypes in synchronous and metachronous primary colorectal cancers diagnostic and therapeutic implications.
Author:	Balschun, Katharina\|Haag, Jochen\|Wenke, Ann-Kathrin\|von Schonfels, Witigo\|Schwarz, Nicolas T\|Rocken, Christoph
PMID:	21704278

133.
Journal:	Br J Cancer. 2011 Jul 12;105(2):246-54.
Title:	Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours.
Author:	Weidlich, S\|Walsh, K\|Crowther, D\|Burczynski, M E\|Feuerstein, G\|Carey, F A\|Steele, R J C\|Wolf, C R\|Miele, G\|Smith, G
PMID:	21712828

134.
Journal:	Clin Colorectal Cancer. 2011 Dec;10(4):279-89.
Title:	Development of molecular biomarkers in individualized treatment of colorectal cancer.
Author:	De Mattos-Arruda, Leticia\|Dienstmann, Rodrigo\|Tabernero, Josep
PMID:	21729679

135.
Journal:	PLoS One. 2011;6(6):e21632.
Title:	Selective BRAFV600E inhibitor PLX4720, requires TRAIL assistance to overcome oncogenic PIK3CA resistance.
Author:	Oikonomou, Eftychia\|Koc, Michal\|Sourkova, Vladimira\|Andera, Ladislav\|Pintzas, Alexander
PMID:	21738740

136.
Journal:	Oncologist. 2011;16(9):1239-49.
Title:	Concordance of predictive markers for EGFR inhibitors in primary tumors and metastases in colorectal cancer: a review.
Author:	Baas, Jara M\|Krens, Lisanne L\|Guchelaar, Henk-Jan\|Morreau, Hans\|Gelderblom, Hans
PMID:	21742964

137.
Journal:	Gan To Kagaku Ryoho. 2011 Jul;38(7):1079-83.
Title:	[Predictive biomarkers of anti-EGFR monoclonal anti-body in colorectal cancer].
Author:	Soeda, Hiroshi\|Shimodaira, Hideki\|Ishioka, Chikashi
PMID:	21772090

138.
Journal:	Transl Oncol. 2011 Aug;4(4):241-8. Epub 2011 Aug 1.
Title:	Glucose metabolism measured by [(1)(8)F]fluorodeoxyglucose positron emission tomography is independent of PTEN/AKT status in human colon carcinoma cells.
Author:	Nguyen, Quang-De\|Perumal, Meg\|Waldman, Todd A\|Aboagye, Eric O
PMID:	21804920

139.
Journal:	Rinsho Byori. 2011 Jun;59(6):598-601.
Title:	[KRAS mutation test].
Author:	Hinoda, Yuji
PMID:	21815483

140.
Journal:	Nat Rev Clin Oncol. 2011 Aug 9;8(12):711-9.
Title:	Cancer immunology--analysis of host and tumor factors for personalized medicine.
Author:	Ogino, Shuji\|Galon, Jerome\|Fuchs, Charles S\|Dranoff, Glenn
PMID:	21826083

141.
Journal:	PLoS One. 2011;6(7):e22769.
Title:	PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers.
Author:	Janku, Filip\|Lee, J Jack\|Tsimberidou, Apostolia M\|Hong, David S\|Naing, Aung\|Falchook, Gerald S\|Fu, Siqing\|Luthra, Rajyalakshmi\|Garrido-Laguna, Ignacio\|Kurzrock, Razelle
PMID:	21829508

142.
Journal:	Cell Oncol (Dordr). 2011 Dec;34(6):523-31.
Title:	PIK3CA kinase domain mutation identifies a subgroup of stage III colon cancer patients with poor prognosis.
Author:	Farina Sarasqueta, Arantza\|Zeestraten, Eliane C M\|van Wezel, Tom\|van Lijnschoten, Gesina\|van Eijk, Ronald\|Dekker, Jan Willem T\|Kuppen, Peter J K\|Goossens-Beumer, Ines J\|Lemmens, Valery E P P\|van de Velde, Cornelis J H\|Rutten, Harm J T\|Morreau, Hans\|van de
PMID:	21830111

143.
Journal:	PLoS One. 2011;6(9):e25062.
Title:	TGFBR2 and BAX mononucleotide tract mutations, microsatellite instability, and prognosis in 1072 colorectal cancers.
Author:	Shima, Kaori\|Morikawa, Teppei\|Yamauchi, Mai\|Kuchiba, Aya\|Imamura, Yu\|Liao, Xiaoyun\|Meyerhardt, Jeffrey A\|Fuchs, Charles S\|Ogino, Shuji
PMID:	21949851

144.
Journal:	PLoS One. 2011;6(9):e25132.
Title:	The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.
Author:	Roper, Jatin\|Richardson, Michael P\|Wang, Wei Vivian\|Richard, Larissa Georgeon\|Chen, Wei\|Coffee, Erin M\|Sinnamon, Mark J\|Lee, Lydia\|Chen, Peng-Chieh\|Bronson, Roderick T\|Martin, Eric S\|Hung, Kenneth E
PMID:	21966435

145.
Journal:	Nutr Cancer. 2011 Nov;63(8):1226-34.
Title:	Diet and colorectal cancer: analysis of a candidate pathway using SNPS, haplotypes, and multi-gene assessment.
Author:	Slattery, Martha L\|Lundgreen, Abbie\|Herrick, Jennifer S\|Caan, Bette J\|Potter, John D\|Wolff, Roger K
PMID:	21999454

146.
Journal:	Genome Biol. 2011 Oct 19;12(10):R103.
Title:	Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer.
Author:	Kloosterman, Wigard P\|Hoogstraat, Marlous\|Paling, Oscar\|Tavakoli-Yaraki, Masoumeh\|Renkens, Ivo\|Vermaat, Joost S\|van Roosmalen, Markus J\|van Lieshout, Stef\|Nijman, Isaac J\|Roessingh, Wijnand\|van 't Slot, Ruben\|van de Belt, Jose\|Guryev, Victor\|Koudijs, Marc
PMID:	22014273

147.
Journal:	Pathol Res Pract. 2011 Dec 15;207(12):762-8.
Title:	Frequency of KRAS, BRAF, and PIK3CA mutations in advanced colorectal cancers: Comparison of peptide nucleic acid-mediated PCR clamping and direct sequencing in formalin-fixed, paraffin-embedded tissue.
Author:	Kwon, Mi Jung\|Lee, Seung Eun\|Kang, So Young\|Choi, Yoon-La
PMID:	22070922

148.
Journal:	Cesk Patol. 2011 Oct;47(4):154-8.
Title:	[Molecular predictive markers of EGFR-targeted therapy in metastatic colorectal cancer].
Author:	Fabian, P\|Berkovcova, J
PMID:	22145213

149.
Journal:	Cancer Discov. 2011 Nov;1(6):508-23.
Title:	A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer.
Author:	Bertotti, Andrea\|Migliardi, Giorgia\|Galimi, Francesco\|Sassi, Francesco\|Torti, Davide\|Isella, Claudio\|Cora, Davide\|Di Nicolantonio, Federica\|Buscarino, Michela\|Petti, Consalvo\|Ribero, Dario\|Russolillo, Nadia\|Muratore, Andrea\|Massucco, Paolo\|Pisacane, Alber
PMID:	22586653

150.
Journal:	Int J Cancer. 2012 Feb 15;130(4):837-46.
Title:	Increased frequency of 20q gain and copy-neutral loss of heterozygosity in mismatch repair proficient familial colorectal carcinomas.
Author:	Middeldorp, A\|van Eijk, R\|Oosting, J\|Forte, G I\|van Puijenbroek, M\|van Nieuwenhuizen, M\|Corver, W E\|Ruano, D\|Caldes, T\|Wijnen, J\|Morreau, H\|van Wezel, T
PMID:	21445971

151.
Journal:	Cell Biochem Biophys. 2012 Jan;62(1):47-54.
Title:	Studies on the expression patterns of class I PI3K catalytic subunits and its prognostic significance in colorectal cancer.
Author:	Cui, Binbin\|Tao, Ji\|Yang, Yanmei
PMID:	21910030

152.
Journal:	Int J Cancer. 2012 Aug 15;131(4):813-20.
Title:	Oncogenic PIK3CA mutations in colorectal cancers and polyps.
Author:	Whitehall, Vicki L J\|Rickman, Celestine\|Bond, Catherine E\|Ramsnes, Ingunn\|Greco, Sonia A\|Umapathy, Aarti\|McKeone, Diane\|Faleiro, Rebecca J\|Buttenshaw, Ron L\|Worthley, Daniel L\|Nayler, Sam\|Zhao, Zhen Zhen\|Montgomery, Grant W\|Mallitt, Kylie-Ann\|Jass, Jeremy
PMID:	21932420

153.
Journal:	Int J Cancer. 2012 Sep 1;131(5):1169-78.
Title:	Tumor TP53 expression status, body mass index and prognosis in colorectal cancer.
Author:	Morikawa, Teppei\|Kuchiba, Aya\|Liao, Xiaoyun\|Imamura, Yu\|Yamauchi, Mai\|Qian, Zhi Rong\|Nishihara, Reiko\|Sato, Kaori\|Meyerhardt, Jeffrey A\|Fuchs, Charles S\|Ogino, Shuji
PMID:	22038927

154.
Journal:	Ann Oncol. 2012 Jun;23(6):1518-25.
Title:	PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis.
Author:	Mao, C\|Yang, Z Y\|Hu, X F\|Chen, Q\|Tang, J L
PMID:	22039088

155.
Journal:	Mol Cancer Ther. 2012 Mar;11(3):720-9.
Title:	Comprehensive predictive biomarker analysis for MEK inhibitor GSK1120212.
Author:	Jing, Junping\|Greshock, Joel\|Holbrook, Joanna Dawn\|Gilmartin, Aidan\|Zhang, Xiping\|McNeil, Elizabeth\|Conway, Theresa\|Moy, Christopher\|Laquerre, Sylvie\|Bachman, Kurt\|Wooster, Richard\|Degenhardt, Yan
PMID:	22169769

156.
Journal:	Ann Surg Oncol. 2012 Jun;19(6):1944-53.
Title:	Prognostic significance and molecular associations of tumor growth pattern in colorectal cancer.
Author:	Morikawa, Teppei\|Kuchiba, Aya\|Qian, Zhi Rong\|Mino-Kenudson, Mari\|Hornick, Jason L\|Yamauchi, Mai\|Imamura, Yu\|Liao, Xiaoyun\|Nishihara, Reiko\|Meyerhardt, Jeffrey A\|Fuchs, Charles S\|Ogino, Shuji
PMID:	22189472

157.
Journal:	Curr Cancer Drug Targets. 2012 Feb;12(2):124-31.
Title:	Analysis of the concordance in the EGFR pathway status between primary tumors and related metastases of colorectal cancer patients:implications for cancer therapy.
Author:	Cejas, P\|Lopez-Gomez, M\|Aguayo, C\|Madero, R\|Moreno-Rubio, J\|de Castro Carpeno, J\|Belda-Iniesta, C\|Barriuso, J\|Moreno Garcia, V\|Diaz, E\|Burgos, E\|Gonzalez-Baron, M\|Feliu, J
PMID:	22229245

158.
Journal:	Recent Pat Anticancer Drug Discov. 2012 May 1;7(2):233-47.
Title:	Emerging role of cetuximab in the treatment of colorectal cancer.
Author:	Papa, Anselmo\|Rossi, Luigi\|Lo Russo, Giuseppe\|Giordani, Erika\|Spinelli, Gian Paolo\|Zullo, Angelo\|Petrozza, Vincenzo\|Tomao, Silverio
PMID:	22264223

159.
Journal:	Invest New Drugs. 2012 Dec;30(6):2219-25.
Title:	Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer.
Author:	Atreya, Chloe E\|Ducker, Gregory S\|Feldman, Morris E\|Bergsland, Emily K\|Warren, Robert S\|Shokat, Kevan M
PMID:	22270257

160.
Journal:	Clin Colorectal Cancer. 2012 Jun;11(2):143-50.
Title:	PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal growth factor receptor antibody therapy in patients with KRAS wild-type metastatic colorectal cancer.
Author:	Sood, Arjun\|McClain, Danielle\|Maitra, Radhashree\|Basu-Mallick, Atrayee\|Seetharam, Raviraja\|Kaubisch, Andreas\|Rajdev, Lakshmi\|Mariadason, John M\|Tanaka, Kathryn\|Goel, Sanjay
PMID:	22285706

161.
Journal:	Int J Cancer. 2012 Oct 15;131(8):1790-9.
Title:	Colorectal serrated adenocarcinoma shows a different profile of oncogene mutations, MSI status and DNA repair protein expression compared to conventional and sporadic MSI-H carcinomas.
Author:	Garcia-Solano, J\|Conesa-Zamora, P\|Carbonell, P\|Trujillo-Santos, J\|Torres-Moreno D, D\|Pagan-Gomez, I\|Rodriguez-Braun, E\|Perez-Guillermo, M
PMID:	22287190

162.
Journal:	Clin Cancer Res. 2012 Apr 15;18(8):2257-68.
Title:	Prognostic role of PIK3CA mutation in colorectal cancer: cohort study and literature review.
Author:	Liao, Xiaoyun\|Morikawa, Teppei\|Lochhead, Paul\|Imamura, Yu\|Kuchiba, Aya\|Yamauchi, Mai\|Nosho, Katsuhiko\|Qian, Zhi Rong\|Nishihara, Reiko\|Meyerhardt, Jeffrey A\|Fuchs, Charles S\|Ogino, Shuji
PMID:	22357840

163.
Journal:	Clin Cancer Res. 2012 May 1;18(9):2515-25.
Title:	Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas.
Author:	Migliardi, Giorgia\|Sassi, Francesco\|Torti, Davide\|Galimi, Francesco\|Zanella, Eugenia R\|Buscarino, Michela\|Ribero, Dario\|Muratore, Andrea\|Massucco, Paolo\|Pisacane, Alberto\|Risio, Mauro\|Capussotti, Lorenzo\|Marsoni, Silvia\|Di Nicolantonio, Federica\|Bardelli,
PMID:	22392911

164.
Journal:	Gut. 2012 Jun;61(6):847-54.
Title:	Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum.
Author:	Yamauchi, Mai\|Morikawa, Teppei\|Kuchiba, Aya\|Imamura, Yu\|Qian, Zhi Rong\|Nishihara, Reiko\|Liao, Xiaoyun\|Waldron, Levi\|Hoshida, Yujin\|Huttenhower, Curtis\|Chan, Andrew T\|Giovannucci, Edward\|Fuchs, Charles\|Ogino, Shuji
PMID:	22427238

165.
Journal:	Arch Surg. 2012 Aug;147(8):715-23.
Title:	Predictors of lymph node count in colorectal cancer resections: data from US nationwide prospective cohort studies.
Author:	Morikawa, Teppei\|Tanaka, Noriko\|Kuchiba, Aya\|Nosho, Katsuhiko\|Yamauchi, Mai\|Hornick, Jason L\|Swanson, Richard S\|Chan, Andrew T\|Meyerhardt, Jeffrey A\|Huttenhower, Curtis\|Schrag, Deborah\|Fuchs, Charles S\|Ogino, Shuji
PMID:	22508672

166.
Journal:	Cancer Chemother Pharmacol. 2012 Jun;69(6):1601-15.
Title:	Selective PI3K inhibition by BKM120 and BEZ235 alone or in combination with chemotherapy in wild-type and mutated human gastrointestinal cancer cell lines.
Author:	Mueller, Annett\|Bachmann, Erika\|Linnig, Monika\|Khillimberger, Katrin\|Schimanski, Carl Christoph\|Galle, Peter R\|Moehler, Markus
PMID:	22543857

167.
Journal:	Clin Cancer Res. 2012 May 1;18(9):2704-14.
Title:	Common PIK3CA mutants and a novel 3' UTR mutation are associated with increased sensitivity to saracatinib.
Author:	Arcaroli, John J\|Quackenbush, Kevin S\|Powell, Rebecca W\|Pitts, Todd M\|Spreafico, Anna\|Varella-Garcia, Marileila\|Bemis, Lynne\|Tan, Aik Choon\|Reinemann, Jaclyn M\|Touban, Basel M\|Dasari, Arvind\|Eckhardt, S Gail\|Messersmith, Wells A
PMID:	22553375

168.
Journal:	Gastrointest Cancer Res. 2012 Jan;5(1):19-27.
Title:	Genetic alterations in colorectal cancer.
Author:	Armaghany, Tannaz\|Wilson, Jon D\|Chu, Quyen\|Mills, Glenn
PMID:	22574233

169.
Journal:	Clin Chim Acta. 2012 Oct 9;413(19-20):1605-11.
Title:	Characteristics and prevalence of KRAS, BRAF, and PIK3CA mutations in colorectal cancer by high-resolution melting analysis in Taiwanese population.
Author:	Hsieh, Li-Ling\|Er, Tze-Kiong\|Chen, Chih-Chieh\|Hsieh, Jan-Sing\|Chang, Jan-Gowth\|Liu, Ta-Chih
PMID:	22579930

170.
Journal:	PLoS One. 2012;7(5):e36653.
Title:	KRAS, BRAF and PIK3CA mutations and the loss of PTEN expression in Chinese patients with colorectal cancer.
Author:	Mao, Chen\|Zhou, Junhua\|Yang, Zuyao\|Huang, Yafang\|Wu, Xinyin\|Shen, Hong\|Tang, Jinling\|Chen, Qing
PMID:	22586484

171.
Journal:	Anticancer Res. 2012 May;32(5):1621-6.
Title:	Utility of cell-free tumour DNA for post-surgical follow-up of colorectal cancer patients.
Author:	Levy, Miroslav\|Benesova, Lucie\|Lipska, Ludmila\|Belsanova, Barbora\|Minarikova, Petra\|Veprekova, Gabriela\|Zavoral, Miroslav\|Minarik, Marek
PMID:	22593440

172.
Journal:	J Clin Oncol. 2012 Aug 20;30(24):2956-62.
Title:	Comparative genomic analysis of primary versus metastatic colorectal carcinomas.
Author:	Vakiani, Efsevia\|Janakiraman, Manickam\|Shen, Ronglai\|Sinha, Rileen\|Zeng, Zhaoshi\|Shia, Jinru\|Cercek, Andrea\|Kemeny, Nancy\|D'Angelica, Michael\|Viale, Agnes\|Heguy, Adriana\|Paty, Philip\|Chan, Timothy A\|Saltz, Leonard B\|Weiser, Martin\|Solit, David B
PMID:	22665543

173.
Journal:	PLoS One. 2012;7(5):e38033.
Title:	KRASness and PIK3CAness in patients with advanced colorectal cancer: outcome after treatment with early-phase trials with targeted pathway inhibitors.
Author:	Garrido-Laguna, Ignacio\|Hong, David S\|Janku, Filip\|Nguyen, Ly M\|Falchook, Gerald S\|Fu, Siqing\|Wheler, Jenifer J\|Luthra, Rajyalakshmi\|Naing, Aung\|Wang, Xuemei\|Kurzrock, Razelle
PMID:	22675430

174.
Journal:	Carcinogenesis. 2012 Sep;33(9):1782-90.
Title:	Sorafenib enhances the therapeutic efficacy of rapamycin in colorectal cancers harboring oncogenic KRAS and PIK3CA.
Author:	Gulhati, Pat\|Zaytseva, Yekaterina Y\|Valentino, Joseph D\|Stevens, Payton D\|Kim, Ji Tae\|Sasazuki, Takehiko\|Shirasawa, Senji\|Lee, Eun Y\|Weiss, Heidi L\|Dong, Jianli\|Gao, Tianyan\|Evers, B Mark
PMID:	22696593

175.
Journal:	Mol Cancer Ther. 2012 Sep;11(9):2062-71.
Title:	Molecular profiling of patients with colorectal cancer and matched targeted therapy in phase I clinical trials.
Author:	Dienstmann, Rodrigo\|Serpico, Danila\|Rodon, Jordi\|Saura, Cristina\|Macarulla, Teresa\|Elez, Elena\|Alsina, Maria\|Capdevila, Jaume\|Perez-Garcia, Jose\|Sanchez-Olle, Gessami\|Aura, Claudia\|Prudkin, Ludmila\|Landolfi, Stefania\|Hernandez-Losa, Javier\|Vivancos, Ana\|T
PMID:	22723336

176.
Journal:	Oncol Lett. 2012 Mar;3(3):565-570.
Title:	PIK3CA mutation and methylation influences the outcome of colorectal cancer.
Author:	Iida, Satoru\|Kato, Shunsuke\|Ishiguro, Megumi\|Matsuyama, Takatoshi\|Ishikawa, Toshiaki\|Kobayashi, Hirotoshi\|Higuchi, Tetsuro\|Uetake, Hiroyuki\|Enomoto, Masayuki\|Sugihara, Kenichi
PMID:	22740953

177.
Journal:	Oncol Lett. 2012 Mar;3(3):649-653.
Title:	Acquired/intratumoral mutation of KRAS during metastatic progression of colorectal carcinogenesis.
Author:	Otsuka, Kazunori\|Satoyoshi, Rika\|Nanjo, Hiroshi\|Miyazawa, Hideaki\|Abe, Yuki\|Tanaka, Masamitsu\|Yamamoto, Yuzo\|Shibata, Hiroyuki
PMID:	22740969

178.
Journal:	Mol Cancer Ther. 2012 Sep;11(9):1884-93.
Title:	Killing of Kras-mutant colon cancer cells via Rac-independent actin remodeling by the betaGBP cytokine, a physiological PI3K inhibitor therapeutically effective in vivo.
Author:	Mallucci, Livio\|Shi, Dong-yun\|Davies, Derek\|Jordan, Peter\|Nicol, Alastair\|Lotti, Lavinia\|Mariani-Costantini, Renato\|Verginelli, Fabio\|Wells, Valerie\|Zicha, Daniel
PMID:	22752425

179.
Journal:	Clin Cancer Res. 2012 Sep 1;18(17):4753-63.
Title:	Specific mutations in KRAS codons 12 and 13, and patient prognosis in 1075 BRAF wild-type colorectal cancers.
Author:	Imamura, Yu\|Morikawa, Teppei\|Liao, Xiaoyun\|Lochhead, Paul\|Kuchiba, Aya\|Yamauchi, Mai\|Qian, Zhi Rong\|Nishihara, Reiko\|Meyerhardt, Jeffrey A\|Haigis, Kevin M\|Fuchs, Charles S\|Ogino, Shuji
PMID:	22753589

180.
Journal:	World J Gastroenterol. 2012 Jul 14;18(26):3458-64.
Title:	Phosphoinositide-3-kinase, catalytic, alpha polypeptide RNA interference inhibits growth of colon cancer cell SW948.
Author:	Huang, Wen-Sheng\|Wang, Tian-Bao\|He, Yao\|Chen, Yu-Jun\|Zhong, Shi-Long\|Tan, Min
PMID:	22807617

181.
Journal:	Nature. 2012 Jul 18;487(7407):330-7.
Title:	Comprehensive molecular characterization of human colon and rectal cancer.
Author:
PMID:	22810696

182.
Journal:	Surgery. 2012 Aug;152(2):277-85.
Title:	Novel small interfering RNA cotargeting strategy as treatment for colorectal cancer.
Author:	Valentino, Joseph D\|Elliott, Victoria A\|Zaytseva, Yekaterina Y\|Rychahou, Piotr G\|Mustain, W Conan\|Wang, Chi\|Gao, Tianyan\|Evers, B Mark
PMID:	22828149

183.
Journal:	Eur J Cancer. 2012 Dec;48(18):3405-13.
Title:	Insulin-like growth factor 2 messenger RNA binding protein 3 (IGF2BP3) is a marker of unfavourable prognosis in colorectal cancer.
Author:	Lochhead, Paul\|Imamura, Yu\|Morikawa, Teppei\|Kuchiba, Aya\|Yamauchi, Mai\|Liao, Xiaoyun\|Qian, Zhi Rong\|Nishihara, Reiko\|Wu, Kana\|Meyerhardt, Jeffrey A\|Fuchs, Charles S\|Ogino, Shuji
PMID:	22840368

184.
Journal:	World J Gastroenterol. 2012 Jul 28;18(28):3745-51.
Title:	PI3K expression and PIK3CA mutations are related to colorectal cancer metastases.
Author:	Zhu, Yu-Fen\|Yu, Bao-Hua\|Li, Da-Li\|Ke, Hong-Lin\|Guo, Xian-Zhi\|Xiao, Xiu-Ying
PMID:	22851869

185.
Journal:	Histopathology. 2012 Dec;61(6):1117-24.
Title:	The utility of diagnostic biopsy specimens for predictive molecular testing in colorectal cancer.
Author:	Fadhil, Wakkas\|Ibrahem, Salih\|Seth, Rashmi\|AbuAli, Ghada\|Ragunath, Krishna\|Kaye, Philip\|Ilyas, Mohammad
PMID:	22882224

186.
Journal:	PLoS One. 2012;7(7):e41347.
Title:	Antitumoral efficacy of the protease inhibitor gabexate mesilate in colon cancer cells harbouring KRAS, BRAF and PIK3CA mutations.
Author:	Brandi, Giovanni\|Tavolari, Simona\|De Rosa, Francesco\|Di Girolamo, Stefania\|Agostini, Valentina\|Barbera, Maria Aurelia\|Frega, Giorgio\|Biasco, Guido
PMID:	22911782

187.
Journal:	Clin Cancer Res. 2012 Oct 15;18(20):5796-805.
Title:	Phase I study of the antiangiogenic antibody bevacizumab and the mTOR/hypoxia-inducible factor inhibitor temsirolimus combined with liposomal doxorubicin: tolerance and biological activity.
Author:	Moroney, John\|Fu, Siqing\|Moulder, Stacy\|Falchook, Gerald\|Helgason, Thorunn\|Levenback, Charles\|Hong, David\|Naing, Aung\|Wheler, Jennifer\|Kurzrock, Razelle
PMID:	22927482

188.
Journal:	J Transl Med. 2012 Aug 29;10:178.
Title:	Prevalence of KRAS, BRAF, and PIK3CA somatic mutations in patients with colorectal carcinoma may vary in the same population: clues from Sardinia.
Author:	Palomba, Grazia\|Colombino, Maria\|Contu, Antonio\|Massidda, Bruno\|Baldino, Giovanni\|Pazzola, Antonio\|Ionta, MariaTeresa\|Capelli, Francesca\|Trova, Vittorio\|Sedda, Tito\|Sanna, Giovanni\|Tanda, Francesco\|Budroni, Mario\|Palmieri, Giuseppe\|Cossu, Antonio\|Contu, M
PMID:	22931052

189.
Journal:	Arch Pathol Lab Med. 2012 Sep;136(9):983-92.
Title:	High-resolution melting analysis as a sensitive prescreening diagnostic tool to detect KRAS , BRAF , PIK3CA , and AKT1 mutations in formalin-fixed, paraffin-embedded tissues.
Author:	Ney, Jasmin Teresa\|Froehner, Stefanie\|Roesler, Angelika\|Buettner, Reinhard\|Merkelbach-Bruse, Sabine
PMID:	22938585

190.
Journal:	Exp Ther Med. 2012 Mar;3(3):547-549.
Title:	Possibility of molecular targeting therapy for the treatment of cancer of unknown primary origin by analysis of intracellular signaling molecules.
Author:	Ohta, Shoichiro\|Cho, Yukiko\|Shibata, Masaharu\|Nagai, Kimihiro\|Iijima, Tatsuo\|Saito, Hitoaki\|Asakura, Hirotaka\|Kojima, Hiroshi
PMID:	22969927

191.
Journal:	Acta Pharmacol Sin. 2012 Dec;33(12):1441-58.
Title:	PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes.
Author:	Pal, Ipsita\|Mandal, Mahitosh
PMID:	22983389

192.
Journal:	Am J Pathol. 2012 Nov;181(5):1847-61.
Title:	Molecular dissection of premalignant colorectal lesions reveals early onset of the CpG island methylator phenotype.
Author:	Yamamoto, Eiichiro\|Suzuki, Hiromu\|Yamano, Hiro-o\|Maruyama, Reo\|Nojima, Masanori\|Kamimae, Seiko\|Sawada, Takeshi\|Ashida, Masami\|Yoshikawa, Kenjiro\|Kimura, Tomoaki\|Takagi, Ryo\|Harada, Taku\|Suzuki, Ryo\|Sato, Akiko\|Kai, Masahiro\|Sasaki, Yasushi\|Tokino, Takashi
PMID:	22995252

193.
Journal:	Nature. 2012 Nov 8;491(7423):254-8.
Title:	Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Author:	Grivennikov, Sergei I\|Wang, Kepeng\|Mucida, Daniel\|Stewart, C Andrew\|Schnabl, Bernd\|Jauch, Dominik\|Taniguchi, Koji\|Yu, Guann-Yi\|Osterreicher, Christoph H\|Hung, Kenneth E\|Datz, Christian\|Feng, Ying\|Fearon, Eric R\|Oukka, Mohamed\|Tessarollo, Lino\|Coppola, Vin
PMID:	23034650

194.
Journal:	Clin Cancer Res. 2012 Dec 1;18(23):6531-41.
Title:	Mutation profiling and microsatellite instability in stage II and III colon cancer: an assessment of their prognostic and oxaliplatin predictive value.
Author:	Gavin, Patrick G\|Colangelo, Linda H\|Fumagalli, Debora\|Tanaka, Noriko\|Remillard, Matthew Y\|Yothers, Greg\|Kim, Chungyeul\|Taniyama, Yusuke\|Kim, Seung Il\|Choi, Hyun Joo\|Blackmon, Nicole L\|Lipchik, Corey\|Petrelli, Nicholas J\|O'Connell, Michael J\|Wolmark, Norma
PMID:	23045248

195.
Journal:	World J Gastroenterol. 2012 Oct 7;18(37):5171-80.
Title:	KRAS mutation testing in metastatic colorectal cancer.
Author:	Tan, Cong\|Du, Xiang
PMID:	23066310

196.
Journal:	N Engl J Med. 2012 Oct 25;367(17):1596-606.
Title:	Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival.
Author:	Liao, Xiaoyun\|Lochhead, Paul\|Nishihara, Reiko\|Morikawa, Teppei\|Kuchiba, Aya\|Yamauchi, Mai\|Imamura, Yu\|Qian, Zhi Rong\|Baba, Yoshifumi\|Shima, Kaori\|Sun, Ruifang\|Nosho, Katsuhiko\|Meyerhardt, Jeffrey A\|Giovannucci, Edward\|Fuchs, Charles S\|Chan, Andrew T\|Ogino
PMID:	23094721

197.
Journal:	Int J Biol Markers. 2012 Dec 27;27(4):e366-74.
Title:	Survey of KRAS, BRAF and PIK3CA mutational status in 209 consecutive Italian colorectal cancer patients.
Author:	Bozzao, Cristina\|Varvara, Dora\|Piglionica, Marilidia\|Bagnulo, Rosanna\|Forte, Giovanna\|Patruno, Margherita\|Russo, Silvana\|Piscitelli, Domenico\|Stella, Alessandro\|Resta, Nicoletta
PMID:	23125007

198.
Journal:	Gan To Kagaku Ryoho. 2012 Nov;39(11):1618-25.
Title:	[Predictive biomarkers for anti-EGFR antibodies].
Author:	Bando, Hideaki\|Yoshino, Takayuki
PMID:	23152013

199.
Journal:	Zhonghua Bing Li Xue Za Zhi. 2012 Sep;41(9):590-4.
Title:	[Detection of KRAS, BRAF, PIK3CA and EGFR gene mutations in colorectal carcinoma].
Author:	Ling, Yun\|Ying, Jian-ming\|Qiu, Tian\|Shan, Ling\|Guo, Lei\|Lu, Ning
PMID:	23157825

200.
Journal:	Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21046-51.
Title:	Direct and immune mediated antibody targeting of ERBB receptors in a colorectal cancer cell-line panel.
Author:	Ashraf, Shazad Q\|Nicholls, Angela M\|Wilding, Jennifer L\|Ntouroupi, Triantafyllia G\|Mortensen, Neil J\|Bodmer, Walter F
PMID:	23213241

201.
Journal:	PLoS One. 2012;7(11):e50806.
Title:	Tumor phosphatidylinositol-3-kinase signaling and development of metastatic disease in locally advanced rectal cancer.
Author:	Ree, Anne Hansen\|Kristensen, Annette Torgunrud\|Saelen, Marie Gron\|de Wijn, Rik\|Edvardsen, Hege\|Jovanovic, Jovana\|Abrahamsen, Torveig Weum\|Dueland, Svein\|Flatmark, Kjersti
PMID:	23226389

202.
Journal:	Zhonghua Wai Ke Za Zhi. 2012 Nov;50(11):1007-10.
Title:	[A study of the relationship between the mutation of PIK3CA, PTEN and the occurrence of liver metastasis of colorectal cancer: survival analysis].
Author:	Liang, Li\|Wei, Ye\|Ren, Li\|Zhong, Yun-shi\|Xu, Jian-min
PMID:	23302486

203.
Journal:	Asian Pac J Cancer Prev. 2012;13(11):5599-603.
Title:	Mutational analysis of key EGFR pathway genes in Chinese breast cancer patients.
Author:	Tong, Lin\|Yang, Xue-Xi\|Liu, Min-Feng\|Yao, Guang-Yu\|Dong, Jian-Yu\|Ye, Chang-Sheng\|Li, Ming
PMID:	23317280

204.
Journal:	Int J Clin Oncol. 2013 Aug;18(4):670-7.
Title:	Clinical usefulness of KRAS, BRAF, and PIK3CA mutations as predictive markers of cetuximab efficacy in irinotecan- and oxaliplatin-refractory Japanese patients with metastatic colorectal cancer.
Author:	Soeda, Hiroshi\|Shimodaira, Hideki\|Watanabe, Mika\|Suzuki, Takao\|Gamoh, Makio\|Mori, Takahiro\|Komine, Keigo\|Iwama, Noriyuki\|Kato, Shunsuke\|Ishioka, Chikashi
PMID:	22638623

205.
Journal:	Crit Rev Oncol Hematol. 2013 Jan;85(1):45-81.
Title:	Prognostic and predictive biomarkers for epidermal growth factor receptor-targeted therapy in colorectal cancer: beyond KRAS mutations.
Author:	Custodio, Ana\|Feliu, Jaime
PMID:	22647972

206.
Journal:	Int J Radiat Oncol Biol Phys. 2013 Jan 1;85(1):201-7.
Title:	KRAS mutation status and clinical outcome of preoperative chemoradiation with cetuximab in locally advanced rectal cancer: a pooled analysis of 2 phase II trials.
Author:	Kim, Sun Young\|Shim, Eun Kyung\|Yeo, Hyun Yang\|Baek, Ji Yeon\|Hong, Yong Sang\|Kim, Dae Yong\|Kim, Tae Won\|Kim, Jee Hyun\|Im, Seock-Ah\|Jung, Kyung Hae\|Chang, Hee Jin
PMID:	22672749

207.
Journal:	Gut. 2013 Apr;62(4):540-9.
Title:	A combined oncogenic pathway signature of BRAF, KRAS and PI3KCA mutation improves colorectal cancer classification and cetuximab treatment prediction.
Author:	Tian, Sun\|Simon, Iris\|Moreno, Victor\|Roepman, Paul\|Tabernero, Josep\|Snel, Mireille\|van't Veer, Laura\|Salazar, Ramon\|Bernards, Rene\|Capella, Gabriel
PMID:	22798500

208.
Journal:	Mod Pathol. 2013 Feb;26(2):302-13.
Title:	Combined analysis of KRAS and PIK3CA mutations, MET and PTEN expression in primary tumors and corresponding metastases in colorectal cancer.
Author:	Voutsina, Alexandra\|Tzardi, Maria\|Kalikaki, Aristea\|Zafeiriou, Zafeiris\|Papadimitraki, Elsa\|Papadakis, Michael\|Mavroudis, Dimitris\|Georgoulias, Vassilis
PMID:	22936063

209.
Journal:	Hum Pathol. 2013 Feb;44(2):199-207.
Title:	PIK3CA overexpression is a possible prognostic factor for favorable survival in ovarian clear cell carcinoma.
Author:	Abe, Azusa\|Minaguchi, Takeo\|Ochi, Hiroyuki\|Onuki, Mamiko\|Okada, Satoshi\|Matsumoto, Koji\|Satoh, Toyomi\|Oki, Akinori\|Yoshikawa, Hiroyuki
PMID:	22955107

210.
Journal:	Antioxid Redox Signal. 2013 Apr 10;18(11):1249-62.
Title:	Aldose reductase inhibition prevents colon cancer growth by restoring phosphatase and tensin homolog through modulation of miR-21 and FOXO3a.
Author:	Saxena, Ashish\|Tammali, Ravinder\|Ramana, Kota V\|Srivastava, Satish K
PMID:	22978663

211.
Journal:	Exp Mol Pathol. 2013 Feb;94(1):103-8.
Title:	HSP27 expression in primary colorectal cancers is dependent on mutation of KRAS and PI3K/AKT activation status and is independent of TP53.
Author:	Ghosh, Anil\|Lai, Cecilia\|McDonald, Sarah\|Suraweera, Nirosha\|Sengupta, Neel\|Propper, David\|Dorudi, Sina\|Silver, Andrew
PMID:	22982087

212.
Journal:	J Cancer Res Clin Oncol. 2013 Feb;139(2):201-9.
Title:	KRAS p.G13D mutations are associated with sensitivity to anti-EGFR antibody treatment in colorectal cancer cell lines.
Author:	Messner, Isabelle\|Cadeddu, Giuseppe\|Huckenbeck, Wolfgang\|Knowles, Helen J\|Gabbert, Helmut E\|Baldus, Stephan E\|Schaefer, Karl-Ludwig
PMID:	23015072

213.
Journal:	Genes Chromosomes Cancer. 2013 Feb;52(2):140-9.
Title:	Association between genomic alterations and metastatic behavior of colorectal cancer identified by array-based comparative genomic hybridization.
Author:	Sawada, Takeshi\|Yamamoto, Eiichiro\|Suzuki, Hiromu\|Nojima, Masanori\|Maruyama, Reo\|Shioi, Yoshihiro\|Akasaka, Risaburo\|Kamimae, Seiko\|Harada, Taku\|Ashida, Masami\|Kai, Masahiro\|Adachi, Yasushi\|Yamamoto, Hiroyuki\|Imai, Kohzoh\|Toyota, Minoru\|Itoh, Fumio\|Sugai,
PMID:	23073979

214.
Journal:	Clin Chem. 2013 Jan;59(1):252-60.
Title:	Heterogeneity of epidermal growth factor receptor status and mutations of KRAS/PIK3CA in circulating tumor cells of patients with colorectal cancer.
Author:	Gasch, Christin\|Bauernhofer, Thomas\|Pichler, Martin\|Langer-Freitag, Sabine\|Reeh, Matthias\|Seifert, Adrian M\|Mauermann, Oliver\|Izbicki, Jakob R\|Pantel, Klaus\|Riethdorf, Sabine
PMID:	23136247

215.
Journal:	Hum Pathol. 2013 May;44(5):829-36.
Title:	Epidermal growth factor receptor, phosphatidylinositol-3-kinase catalytic subunit/PTEN, and KRAS/NRAS/BRAF in primary resected esophageal adenocarcinomas: loss of PTEN is associated with worse clinical outcome.
Author:	Bettstetter, Marcus\|Berezowska, Sabina\|Keller, Gisela\|Walch, Axel\|Feuchtinger, Annette\|Slotta-Huspenina, Julia\|Feith, Marcus\|Drecoll, Enken\|Hofler, Heinz\|Langer, Rupert
PMID:	23158210

216.
Journal:	J Pathol. 2013 Feb;229(3):441-8.
Title:	Use of multivariate analysis to suggest a new molecular classification of colorectal cancer.
Author:	Domingo, Enric\|Ramamoorthy, Rajarajan\|Oukrif, Dahmane\|Rosmarin, Daniel\|Presz, Michal\|Wang, Haitao\|Pulker, Hannah\|Lockstone, Helen\|Hveem, Tarjei\|Cranston, Treena\|Danielsen, Havard\|Novelli, Marco\|Davidson, Brian\|Xu, Zheng-Zhou\|Molloy, Peter\|Johnstone, Elain
PMID:	23165447

217.
Journal:	Nat Rev Clin Oncol. 2013 Jan;10(1):8-10.
Title:	Potential biomarker for aspirin use in colorectal cancer therapy.
Author:	Langley, Ruth E\|Rothwell, Peter M
PMID:	23207797

218.
Journal:	Clin Cancer Res. 2013 Feb 1;19(3):657-67.
Title:	Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents.
Author:	Mao, Muling\|Tian, Feng\|Mariadason, John M\|Tsao, Chun C\|Lemos, Robert Jr\|Dayyani, Farshid\|Gopal, Y N Vashisht\|Jiang, Zhi-Qin\|Wistuba, Ignacio I\|Tang, Xi M\|Bornman, William G\|Bollag, Gideon\|Mills, Gordon B\|Powis, Garth\|Desai, Jayesh\|Gallick, Gary E\|Davies,
PMID:	23251002

219.
Journal:	Expert Opin Biol Ther. 2013 Feb;13(2):241-55.
Title:	Optimizing treatment of metastatic colorectal cancer patients with anti-EGFR antibodies: overcoming the mechanisms of cancer cell resistance.
Author:	Troiani, Teresa\|Zappavigna, Silvia\|Martinelli, Erika\|Addeo, Santolo R\|Stiuso, Paola\|Ciardiello, Fortunato\|Caraglia, Michele
PMID:	23281932

220.
Journal:	Eur J Med Chem. 2013 Feb;60:187-98.
Title:	Synthesis and biological evaluation of novel coumarin-pyrazoline hybrids endowed with phenylsulfonyl moiety as antitumor agents.
Author:	Amin, Kamilia M\|Eissa, Amal A M\|Abou-Seri, Sahar M\|Awadallah, Fadi M\|Hassan, Ghaneya S
PMID:	23291120

221.
Journal:	N Engl J Med. 2013 Jan 17;368(3):289-90.
Title:	Aspirin, PIK3CA mutation, and colorectal-cancer survival.
Author:	Ogino, Shuji\|Liao, Xiaoyun\|Chan, Andrew T
PMID:	23323913

222.
Journal:	N Engl J Med. 2013 Jan 17;368(3):289.
Title:	Aspirin, PIK3CA mutation, and colorectal-cancer survival.
Author:	Viudez, Antonio\|Hernandez, Irene\|Vera, Ruth
PMID:	23323914

223.
Journal:	N Engl J Med. 2013 Jan 17;368(3):289.
Title:	Aspirin, PIK3CA mutation, and colorectal-cancer survival.
Author:	Sahin, Ibrahim H\|Garrett, Christopher
PMID:	23323915

224.
Journal:	Aliment Pharmacol Ther. 2013 Mar;37(5):546-54.
Title:	Stool DNA testing for the detection of colorectal neoplasia in patients with inflammatory bowel disease.
Author:	Kisiel, J B\|Yab, T C\|Nazer Hussain, F T\|Taylor, W R\|Garrity-Park, M M\|Sandborn, W J\|Loftus, E V\|Wolff, B G\|Smyrk, T C\|Itzkowitz, S H\|Rubin, D T\|Zou, H\|Mahoney, D W\|Ahlquist, D A
PMID:	23347191

225.
Journal:	BMC Cancer. 2013 Feb 2;13:49.
Title:	Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes.
Author:	Pentheroudakis, George\|Kotoula, Vassiliki\|De Roock, Wendy\|Kouvatseas, George\|Papakostas, Pavlos\|Makatsoris, Thomas\|Papamichael, Demetris\|Xanthakis, Ioannis\|Sgouros, Joseph\|Televantou, Despina\|Kafiri, Georgia\|Tsamandas, Athanassios C\|Razis, Evangelia\|Galan
PMID:	23374602

226.
Journal:	Br J Cancer. 2013 Mar 5;108(4):771-4.
Title:	Docetaxel plus cetuximab as second-line treatment for docetaxel-refractory oesophagogastric cancer: the AGITG ATTAX2 trial.
Author:	Tebbutt, N C\|Parry, M M\|Zannino, D\|Strickland, A H\|Van Hazel, G A\|Pavlakis, N\|Ganju, V\|Mellor, D\|Dobrovic, A\|Gebski, V J
PMID:	23412099

227.
Journal:	Genet Med. 2013 Jul;15(7):517-27.
Title:	Recommendations from the EGAPP Working Group: can testing of tumor tissue for mutations in EGFR pathway downstream effector genes in patients with metastatic colorectal cancer improve health outcomes by guiding decisions regarding anti-EGFR therapy?
Author:
PMID:	23429431

228.
Journal:	Autophagy. 2013 May;9(5):697-713.
Title:	Energy deprivation by silibinin in colorectal cancer cells: a double-edged sword targeting both apoptotic and autophagic machineries.
Author:	Raina, Komal\|Agarwal, Chapla\|Wadhwa, Ritambhara\|Serkova, Natalie J\|Agarwal, Rajesh
PMID:	23445752

229.
Journal:	Cancer Res. 2013 May 15;73(10):2965-75.
Title:	Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing.
Author:	Heitzer, Ellen\|Auer, Martina\|Gasch, Christin\|Pichler, Martin\|Ulz, Peter\|Hoffmann, Eva Maria\|Lax, Sigurd\|Waldispuehl-Geigl, Julie\|Mauermann, Oliver\|Lackner, Carolin\|Hofler, Gerald\|Eisner, Florian\|Sill, Heinz\|Samonigg, Hellmut\|Pantel, Klaus\|Riethdorf, Sabin
PMID:	23471846

230.
Journal:	Int J Cancer. 2013 Aug 15;133(4):984-96.
Title:	Coexistent mutations of KRAS and PIK3CA affect the efficacy of NVP-BEZ235, a dual PI3K/MTOR inhibitor, in regulating the PI3K/MTOR pathway in colorectal cancer.
Author:	Kim, Areumnuri\|Lee, Jung-Eun\|Lee, Seung-Sook\|Kim, Cherin\|Lee, Sun-Joo\|Jang, Won-Suk\|Park, Sunhoo
PMID:	23475782

231.
Journal:	PLoS One. 2013;8(3):e58089.
Title:	Utilization of quantitative in vivo pharmacology approaches to assess combination effects of everolimus and irinotecan in mouse xenograft models of colorectal cancer.
Author:	Bradshaw-Pierce, Erica L\|Pitts, Todd M\|Kulikowski, Gillian\|Selby, Heather\|Merz, Andrea L\|Gustafson, Daniel L\|Serkova, Natalie J\|Eckhardt, S Gail\|Weekes, Colin D
PMID:	23520486

232.
Journal:	BMC Cancer. 2013 Apr 1;13:169.
Title:	High resolution melting analysis of KRAS, BRAF and PIK3CA in KRAS exon 2 wild-type metastatic colorectal cancer.
Author:	Guedes, Joana G\|Veiga, Isabel\|Rocha, Patricia\|Pinto, Pedro\|Pinto, Carla\|Pinheiro, Manuela\|Peixoto, Ana\|Fragoso, Maria\|Raimundo, Ana\|Ferreira, Paula\|Machado, Manuela\|Sousa, Nuno\|Lopes, Paula\|Araujo, Antonio\|Macedo, Joana\|Alves, Fernando\|Coutinho, Camila\|He
PMID:	23548132

233.
Journal:	Eur J Hum Genet. 2013 Dec;21(12):1383-8.
Title:	Oncogenic mutations and microsatellite instability phenotype predict specific anatomical subsite in colorectal cancer patients.
Author:	Corso, Giovanni\|Pascale, Valeria\|Flauti, Giuseppe\|Ferrara, Francesco\|Marrelli, Daniele\|Roviello, Franco
PMID:	23572025

234.
Journal:	Cancer Res. 2013 Jun 1;73(11):3248-61.
Title:	Single copies of mutant KRAS and mutant PIK3CA cooperate in immortalized human epithelial cells to induce tumor formation.
Author:	Wang, Grace M\|Wong, Hong Yuen\|Konishi, Hiroyuki\|Blair, Brian G\|Abukhdeir, Abde M\|Gustin, John P\|Rosen, D Marc\|Denmeade, Samuel Ray\|Rasheed, Zeshaan\|Matsui, William\|Garay, Joseph P\|Mohseni, Morassa\|Higgins, Michaela J\|Cidado, Justin\|Jelovac, Danijela\|Croes
PMID:	23580570

235.
Journal:	Am J Surg. 2013 May;205(5):608-12; discussion 612.
Title:	Stage III & IV colon and rectal cancers share a similar genetic profile: a review of the Oregon Colorectal Cancer Registry.
Author:	Gawlick, Ute\|Lu, Kim C\|Douthit, Miriam A\|Diggs, Brian S\|Schuff, Kathryn G\|Herzig, Daniel O\|Tsikitis, Vassiliki L
PMID:	23592171

236.
Journal:	PLoS One. 2013 Apr 9;8(4):e60709.
Title:	mTOR inhibition elicits a dramatic response in PI3K-dependent colon cancers.
Author:	Deming, Dustin A\|Leystra, Alyssa A\|Farhoud, Mohammed\|Nettekoven, Laura\|Clipson, Linda\|Albrecht, Dawn\|Washington, Mary Kay\|Sullivan, Ruth\|Weichert, Jamey P\|Halberg, Richard B
PMID:	23593290

237.
Journal:	BMC Cancer. 2013 Apr 23;13:200.
Title:	Impact of KRAS, BRAF and PI3KCA mutations in rectal carcinomas treated with neoadjuvant radiochemotherapy and surgery.
Author:	Derbel, Olfa\|Wang, Qing\|Desseigne, Francoise\|Rivoire, Michel\|Meeus, Pierre\|Peyrat, Patrice\|Stella, Mattia\|Martel-Lafay, Isabelle\|Lemaistre, Anne-Isabelle\|de La Fouchardiere, Christelle
PMID:	23617638

238.
Journal:	Clin Cancer Res. 2013 Jun 15;19(12):3285-96.
Title:	PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer.
Author:	Day, Fiona L\|Jorissen, Robert N\|Lipton, Lara\|Mouradov, Dmitri\|Sakthianandeswaren, Anuratha\|Christie, Michael\|Li, Shan\|Tsui, Cary\|Tie, Jeannie\|Desai, Jayesh\|Xu, Zheng-Zhou\|Molloy, Peter\|Whitehall, Vicki\|Leggett, Barbara A\|Jones, Ian T\|McLaughlin, Stephen\|W
PMID:	23633456

239.
Journal:	Br J Cancer. 2013 May 28;108(10):2153-63.
Title:	The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer.
Author:	Eklof, V\|Wikberg, M L\|Edin, S\|Dahlin, A M\|Jonsson, B-A\|Oberg, A\|Rutegard, J\|Palmqvist, R
PMID:	23660947

240.
Journal:	Ann Surg. 2013 Jun;257(6):1089-95.
Title:	MACC1 mRNA levels predict cancer recurrence after resection of colorectal cancer liver metastases.
Author:	Isella, Claudio\|Mellano, Alfredo\|Galimi, Francesco\|Petti, Consalvo\|Capussotti, Lorenzo\|De Simone, Michele\|Bertotti, Andrea\|Medico, Enzo\|Muratore, Andrea
PMID:	23665971

241.
Journal:	PLoS One. 2013 May 9;8(5):e62989.
Title:	A novel fully automated molecular diagnostic system (AMDS) for colorectal cancer mutation detection.
Author:	Kitano, Shiro\|Myers, Jamie\|Nakamura, Junko\|Yamane, Akio\|Yamashita, Mami\|Nakayama, Masato\|Tsukahara, Yusuke\|Ushida, Hiroshi\|Liu, Wanqing\|Ratain, Mark J\|Amano, Masahiko
PMID:	23671647

242.
Journal:	Lancet Oncol. 2013 Jul;14(8):749-59.
Title:	Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial.
Author:	Seymour, Matthew T\|Brown, Sarah R\|Middleton, Gary\|Maughan, Timothy\|Richman, Susan\|Gwyther, Stephen\|Lowe, Catherine\|Seligmann, Jennifer F\|Wadsley, Jonathan\|Maisey, Nick\|Chau, Ian\|Hill, Mark\|Dawson, Lesley\|Falk, Stephen\|O'Callaghan, Ann\|Benstead, Kim\|Chambe
PMID:	23725851

243.
Journal:	Int J Colorectal Dis. 2013 Dec;28(12):1637-42.
Title:	Descriptive profile of PIK3CA-mutated colorectal cancer in postmenopausal women.
Author:	Phipps, Amanda I\|Makar, Karen W\|Newcomb, Polly A
PMID:	23728594

244.
Journal:	Clin Cancer Res. 2013 Aug 1;19(15):4104-13.
Title:	Somatic profiling of the epidermal growth factor receptor pathway in tumors from patients with advanced colorectal cancer treated with chemotherapy +/- cetuximab.
Author:	Smith, Christopher G\|Fisher, David\|Claes, Bart\|Maughan, Timothy S\|Idziaszczyk, Shelley\|Peuteman, Gilian\|Harris, Rebecca\|James, Michelle D\|Meade, Angela\|Jasani, Bharat\|Adams, Richard A\|Kenny, Sarah\|Kaplan, Richard\|Lambrechts, Diether\|Cheadle, Jeremy P
PMID:	23741067

245.
Journal:	Ann Surg Oncol. 2013 Dec;20 Suppl 3:S527-36.
Title:	Overexpression of hypoxia inducible factor-1 alpha is an independent risk factor for recurrence after curative resection of colorectal liver metastases.
Author:	Shimomura, Manabu\|Hinoi, Takao\|Kuroda, Shintaro\|Adachi, Tomohiro\|Kawaguchi, Yasuo\|Sasada, Tatsunari\|Takakura, Yuji\|Egi, Hiroyuki\|Okajima, Masazumi\|Tashiro, Hirotaka\|Nishizaka, Takashi\|Ohdan, Hideki
PMID:	23748663

246.
Journal:	Br J Cancer. 2013 Jul 23;109(2):408-15.
Title:	Methylation levels of LINE-1 in primary lesion and matched metastatic lesions of colorectal cancer.
Author:	Murata, A\|Baba, Y\|Watanabe, M\|Shigaki, H\|Miyake, K\|Ishimoto, T\|Iwatsuki, M\|Iwagami, S\|Sakamoto, Y\|Miyamoto, Y\|Yoshida, N\|Nosho, K\|Baba, H
PMID:	23764749

247.
Journal:	Exp Cell Res. 2013 Aug 1;319(13):1913-21.
Title:	Selenate induces epithelial-mesenchymal transition in a colorectal carcinoma cell line by AKT activation.
Author:	Tsukamoto, Takanori\|Hama, Susumu\|Kogure, Kentaro\|Tsuchiya, Hiroyuki
PMID:	23769801

248.
Journal:	PLoS One. 2013 Jun 13;8(6):e65479.
Title:	PIK3CA activating mutation in colorectal carcinoma: associations with molecular features and survival.
Author:	Rosty, Christophe\|Young, Joanne P\|Walsh, Michael D\|Clendenning, Mark\|Sanderson, Kristy\|Walters, Rhiannon J\|Parry, Susan\|Jenkins, Mark A\|Win, Aung Ko\|Southey, Melissa C\|Hopper, John L\|Giles, Graham G\|Williamson, Elizabeth J\|English, Dallas R\|Buchanan, Dani
PMID:	23785428

249.
Journal:	JAMA. 2013 Jun 26;309(24):2563-71.
Title:	Aspirin use and risk of colorectal cancer according to BRAF mutation status.
Author:	Nishihara, Reiko\|Lochhead, Paul\|Kuchiba, Aya\|Jung, Seungyoun\|Yamauchi, Mai\|Liao, Xiaoyun\|Imamura, Yu\|Qian, Zhi Rong\|Morikawa, Teppei\|Wang, Molin\|Spiegelman, Donna\|Cho, Eunyoung\|Giovannucci, Edward\|Fuchs, Charles S\|Chan, Andrew T\|Ogino, Shuji
PMID:	23800934

250.
Journal:	J Med Case Rep. 2013 Jun 28;7:170.
Title:	Molecular analysis of appendiceal mucinous cystadenoma and rectal adenocarcinoma in a patient with urothelial carcinoma: a case report.
Author:	Pulighe, Fabio\|Paliogiannis, Panagiotis\|Cossu, Antonio\|Palmieri, Giuseppe\|Colombino, Maria\|Scognamillo, Fabrizio\|Trignano, Mario
PMID:	23809582

251.
Journal:	PLoS One. 2013 Jun 27;8(6):e67258.
Title:	Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation.
Author:	Fang, Douglas D\|Zhang, Cathy C\|Gu, Yin\|Jani, Jitesh P\|Cao, Joan\|Tsaparikos, Konstantinos\|Yuan, Jing\|Thiel, Melissa\|Jackson-Fisher, Amy\|Zong, Qing\|Lappin, Patrick B\|Hayashi, Tomoko\|Schwab, Richard B\|Wong, Anthony\|John-Baptiste, Annette\|Bagrodia, Shubha\|Los
PMID:	23826249

252.
Journal:	Eur J Cancer. 2013 Oct;49(15):3076-82.
Title:	Feasibility of preemptive biomarker profiling for personalised early clinical drug development at a Comprehensive Cancer Center.
Author:	Wiesweg, Marcel\|Ting, Saskia\|Reis, Henning\|Worm, Karl\|Kasper, Stefan\|Tewes, Mitra\|Welt, Anja\|Richly, Heike\|Meiler, Johannes\|Bauer, Sebastian\|Hense, Jorg\|Gauler, Thomas C\|Kohler, Jens\|Eberhardt, Wilfried E\|Darwiche, Kaid\|Freitag, Lutz\|Stamatis, Georgios\|Br
PMID:	23876834

253.
Journal:	J Natl Cancer Inst. 2013 Aug 7;105(15):1151-6.
Title:	Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication.
Author:	Lochhead, Paul\|Kuchiba, Aya\|Imamura, Yu\|Liao, Xiaoyun\|Yamauchi, Mai\|Nishihara, Reiko\|Qian, Zhi Rong\|Morikawa, Teppei\|Shen, Jeanne\|Meyerhardt, Jeffrey A\|Fuchs, Charles S\|Ogino, Shuji
PMID:	23878352

254.
Journal:	Virchows Arch. 2013 Oct;463(4):509-23.
Title:	Alterations in the EGFR pathway coincide in colorectal cancer and impact on prognosis.
Author:	Neumann, Jens\|Wehweck, Laura\|Maatz, Susanne\|Engel, Jutta\|Kirchner, Thomas\|Jung, Andreas
PMID:	23934607

255.
Journal:	Med Oncol. 2013;30(3):686.
Title:	Pattern of clinically relevant mutations in consecutive series of Russian colorectal cancer patients.
Author:	Yanus, Grigoriy A\|Belyaeva, Anna V\|Ivantsov, Alexandr O\|Kuligina, Ekatherina Sh\|Suspitsin, Evgeny N\|Mitiushkina, Natalia V\|Aleksakhina, Svetlana N\|Iyevleva, Aglaya G\|Zaitseva, Olga A\|Yatsuk, Olga S\|Gorodnova, Tatiana V\|Strelkova, Tatiana N\|Efremova, Sofia
PMID:	23943423

256.
Journal:	BMC Gastroenterol. 2013 Aug 19;13:129.
Title:	Morphological change of a laterally spreading rectal tumor over a short period.
Author:	Miyamoto, Hideaki\|Oono, Yasuhiro\|Fu, Kuang-l\|Ikematsu, Hiroaki\|Fujii, Satoshi\|Kojima, Takashi\|Yano, Tomonori\|Ochiai, Atsushi\|Sasaki, Yutaka\|Kaneko, Kazuhiro
PMID:	23957258

257.
Journal:	Zhonghua Wei Chang Wai Ke Za Zhi. 2013 Aug;16(8):753-8.
Title:	[Association of epithermal growth factor receptor expression and its downstream gene mutation status with radiosensitivity of colorectal carcinoma cell lines in vitro].
Author:	Zuo, Zhi-gui\|Yu, Zhi-qi\|Gao, Xian-hua\|Wang, Hao\|Zhang, Chang\|Liu, Qi-zhi\|Han, Yi-fang\|Chen, Li-ping\|Zhang, Xiao-qing\|Fu, Chuan-gang
PMID:	23980047

258.
Journal:	APMIS. 2013 Oct;121(10):954-66.
Title:	Molecular alterations of Ras-Raf-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt signaling pathways in colorectal cancers from a tertiary hospital at Kuala Lumpur, Malaysia.
Author:	Yip, Wai Kien\|Choo, Chee Wei\|Leong, Vincent Ching-Shian\|Leong, Pooi Pooi\|Jabar, Mohd Faisal\|Seow, Heng Fong
PMID:	23992303

259.
Journal:	BMC Cancer. 2013 Sep 3;13:405.
Title:	Simultaneous identification of 36 mutations in KRAS codons 61 and 146, BRAF, NRAS, and PIK3CA in a single reaction by multiplex assay kit.
Author:	Bando, Hideaki\|Yoshino, Takayuki\|Shinozaki, Eiji\|Nishina, Tomohiro\|Yamazaki, Kentaro\|Yamaguchi, Kensei\|Yuki, Satoshi\|Kajiura, Shinya\|Fujii, Satoshi\|Yamanaka, Takeharu\|Tsuchihara, Katsuya\|Ohtsu, Atsushi
PMID:	24006859

260.
Journal:	Am J Gastroenterol. 2013 Nov;108(11):1785-93.
Title:	Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations.
Author:	Mouradov, Dmitri\|Domingo, Enric\|Gibbs, Peter\|Jorissen, Robert N\|Li, Shan\|Soo, Pik Ying\|Lipton, Lara\|Desai, Jayesh\|Danielsen, Havard E\|Oukrif, Dahmane\|Novelli, Marco\|Yau, Christopher\|Holmes, Christopher C\|Jones, Ian T\|McLaughlin, Stephen\|Molloy, Peter\|Hawk
PMID:	24042191

261.
Journal:	Oncogenesis. 2013 Sep 16;2:e71.
Title:	Epigenetic and genetic features of 24 colon cancer cell lines.
Author:	Ahmed, D\|Eide, P W\|Eilertsen, I A\|Danielsen, S A\|Eknaes, M\|Hektoen, M\|Lind, G E\|Lothe, R A
PMID:	24042735

262.
Journal:	J Clin Oncol. 2013 Dec 1;31(34):4297-305.
Title:	Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer.
Author:	Domingo, Enric\|Church, David N\|Sieber, Oliver\|Ramamoorthy, Rajarajan\|Yanagisawa, Yoko\|Johnstone, Elaine\|Davidson, Brian\|Kerr, David J\|Tomlinson, Ian P M\|Midgley, Rachel
PMID:	24062397

263.
Journal:	Mol Cancer Ther. 2013 Dec;12(12):2857-63.
Title:	Target-based therapeutic matching in early-phase clinical trials in patients with advanced colorectal cancer and PIK3CA mutations.
Author:	Ganesan, Prasanth\|Janku, Filip\|Naing, Aung\|Hong, David S\|Tsimberidou, Apostolia M\|Falchook, Gerald S\|Wheler, Jennifer J\|Piha-Paul, Sarina A\|Fu, Siqing\|Stepanek, Vanda M\|Lee, J Jack\|Luthra, Rajyalakshmi\|Overman, Michael J\|Kopetz, E Scott\|Wolff, Robert A\|Ku
PMID:	24092809

264.
Journal:	Mol Cancer Ther. 2013 Dec;12(12):2950-61.
Title:	BRAF V600E is a determinant of sensitivity to proteasome inhibitors.
Author:	Zecchin, Davide\|Boscaro, Valentina\|Medico, Enzo\|Barault, Ludovic\|Martini, Miriam\|Arena, Sabrina\|Cancelliere, Carlotta\|Bartolini, Alice\|Crowley, Emily H\|Bardelli, Alberto\|Gallicchio, Margherita\|Di Nicolantonio, Federica
PMID:	24107445

265.
Journal:	BMC Med Genomics. 2013 Oct 23;6:43.
Title:	Association of candidate single nucleotide polymorphisms with somatic mutation of the epidermal growth factor receptor pathway.
Author:	Wormald, Samuel\|Milla, Liz\|O'Connor, Liam
PMID:	24152305

266.
Journal:	Cancer Med. 2013 Aug;2(4):496-506.
Title:	PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival.
Author:	Atreya, Chloe E\|Sangale, Zaina\|Xu, Nafei\|Matli, Mary R\|Tikishvili, Eliso\|Welbourn, William\|Stone, Steven\|Shokat, Kevan M\|Warren, Robert S
PMID:	24156022

267.
Journal:	J Clin Oncol. 2013 Dec 1;31(34):4358-61.
Title:	Aspirin therapy for colorectal cancer with PIK3CA mutation: simply complex!
Author:	Fuchs, Charles S\|Ogino, Shuji
PMID:	24166520

268.
Journal:	J Natl Cancer Inst. 2013 Dec 4;105(23):1775-6.
Title:	A small cog in a big wheel: PIK3CA mutations in colorectal cancer.
Author:	Stintzing, Sebastian\|Lenz, Heinz-Josef
PMID:	24231451

269.
Journal:	J Natl Cancer Inst. 2013 Dec 4;105(23):1789-98.
Title:	Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial.
Author:	Ogino, Shuji\|Liao, Xiaoyun\|Imamura, Yu\|Yamauchi, Mai\|McCleary, Nadine J\|Ng, Kimmie\|Niedzwiecki, Donna\|Saltz, Leonard B\|Mayer, Robert J\|Whittom, Renaud\|Hantel, Alexander\|Benson, Al B 3rd\|Mowat, Rex B\|Spiegelman, Donna\|Goldberg, Richard M\|Bertagnolli, Monic
PMID:	24231454

270.
Journal:	PLoS One. 2013 Dec 10;8(12):e81628.
Title:	Effectors of epidermal growth factor receptor pathway: the genetic profiling ofKRAS, BRAF, PIK3CA, NRAS mutations in colorectal cancer characteristics and personalized medicine.
Author:	Shen, Yinchen\|Wang, Jianfei\|Han, Xiaohong\|Yang, Hongying\|Wang, Shuai\|Lin, Dongmei\|Shi, Yuankai
PMID:	24339949

271.
Journal:	Cancer Biomark. 2013;13(5):359-66.
Title:	Somatic gene mutations in African Americans may predict worse outcomes in colorectal cancer.
Author:	Kang, Melissa\|Shen, Xiang J\|Kim, Sangmi\|Araujo-Perez, Felix\|Galanko, Joseph A\|Martin, Chris F\|Sandler, Robert S\|Keku, Temitope O
PMID:	24440976

272.
Journal:	Ann Transl Med. 2013 Jul;1(2):12.
Title:	Aspirin for colorectal cancer with PIK3CA mutations: the rising of the oldest targeted therapy?
Author:	Amatu, Alessio\|Bencardino, Katia\|Sartore-Bianchi, Andrea\|Siena, Salvatore
PMID:	25332957

273.
Journal:	Oncogene. 2014 Mar 20;33(12):1590-600.
Title:	Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors.
Author:	Ducker, G S\|Atreya, C E\|Simko, J P\|Hom, Y K\|Matli, M R\|Benes, C H\|Hann, B\|Nakakura, E K\|Bergsland, E K\|Donner, D B\|Settleman, J\|Shokat, K M\|Warren, R S
PMID:	23542178

274.
Journal:	Oncogene. 2014 Apr 24;33(17):2245-54.
Title:	PIK3CA and APC mutations are synergistic in the development of intestinal cancers.
Author:	Deming, D A\|Leystra, A A\|Nettekoven, L\|Sievers, C\|Miller, D\|Middlebrooks, M\|Clipson, L\|Albrecht, D\|Bacher, J\|Washington, M K\|Weichert, J\|Halberg, R B
PMID:	23708654

275.
Journal:	Oncogene. 2014 Jun 5;33(23):2949-55.
Title:	Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology.
Author:	Ogino, S\|Lochhead, P\|Giovannucci, E\|Meyerhardt, J A\|Fuchs, C S\|Chan, A T
PMID:	23792451

276.
Journal:	Int J Cancer. 2014 Mar 1;134(5):1232-8.
Title:	Phosphatidylinositol-3-kinase pathway aberrations in gastric and colorectal cancer: meta-analysis, co-occurrence and ethnic variation.
Author:	Chong, Mei-Ling\|Loh, Marie\|Thakkar, Bhavin\|Pang, Brendan\|Iacopetta, Barry\|Soong, Richie
PMID:	23960014

277.
Journal:	J Gastrointest Cancer. 2014 Mar;45(1):34-9.
Title:	Mutational and clinical predictors of pathologic complete response in the treatment of locally advanced rectal cancer.
Author:	Russo, Andrea L\|Ryan, David P\|Borger, Darrell R\|Wo, Jennifer Y\|Szymonifka, Jackie\|Liang, Wen-Yih\|Kwak, Eunice L\|Blaszkowsky, Lawrence S\|Clark, Jeffrey W\|Allen, Jill N\|Zhu, Andrew X\|Berger, David L\|Cusack, James C\|Mamon, Harvey J\|Haigis, Kevin M\|Hong, Theo
PMID:	24006244

278.
Journal:	Clin Cancer Res. 2014 Feb 1;20(3):744-53.
Title:	PIK3CA, BRAF, and PTEN status and benefit from cetuximab in the treatment of advanced colorectal cancer--results from NCIC CTG/AGITG CO.17.
Author:	Karapetis, Christos S\|Jonker, Derek\|Daneshmand, Manijeh\|Hanson, Jennifer E\|O'Callaghan, Christopher J\|Marginean, Celia\|Zalcberg, John R\|Simes, John\|Moore, Malcolm J\|Tebbutt, Niall C\|Price, Timothy J\|Shapiro, Jeremy D\|Pavlakis, Nick\|Gibbs, Peter\|Van Hazel,
PMID:	24218517

279.
Journal:	Biochem J. 2014 Mar 1;458(2):251-8.
Title:	Physiological expression of the PI3K-activating mutation Pik3ca(H1047R) combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice.
Author:	Hare, Lauren M\|Phesse, Toby J\|Waring, Paul M\|Montgomery, Karen G\|Kinross, Kathryn M\|Mills, Kevin\|Roh, Vincent\|Heath, Joan K\|Ramsay, Robert G\|Ernst, Matthias\|Phillips, Wayne A
PMID:	24320611

280.
Journal:	Hum Mutat. 2014 Mar;35(3):329-40.
Title:	Tumor heterogeneity revealed by KRAS, BRAF, and PIK3CA pyrosequencing: KRAS and PIK3CA intratumor mutation profile differences and their therapeutic implications.
Author:	Kosmidou, Vivian\|Oikonomou, Eftychia\|Vlassi, Margarita\|Avlonitis, Spyros\|Katseli, Anastasia\|Tsipras, Iraklis\|Mourtzoukou, Despina\|Kontogeorgos, Georgios\|Zografos, Georgios\|Pintzas, Alexander
PMID:	24352906

281.
Journal:	Clin Gastroenterol Hepatol. 2014 Mar;12(3):377-81.
Title:	DNA testing and molecular screening for colon cancer.
Author:	Carethers, John M
PMID:	24355100

282.
Journal:	Biochem Biophys Res Commun. 2014 Feb 7;444(2):199-204.
Title:	MicroRNA-375 inhibits colorectal cancer growth by targeting PIK3CA.
Author:	Wang, Yihui\|Tang, Qingchao\|Li, Mingqi\|Jiang, Shixiong\|Wang, Xishan
PMID:	24440701

283.
Journal:	Int J Exp Pathol. 2014 Feb;95(1):16-23.
Title:	DNA content analysis of colorectal cancer defines a distinct 'microsatellite and chromosome stable' group but does not predict response to radiotherapy.
Author:	Fadhil, Wakkas\|Kindle, Karin\|Jackson, Darryl\|Zaitoun, Abed\|Lane, Nina\|Robins, Adrian\|Ilyas, Mohammad
PMID:	24456329

284.
Journal:	Cancer Chemother Pharmacol. 2014 Apr;73(4):749-57.
Title:	Overexpression of MET is a new predictive marker for anti-EGFR therapy in metastatic colorectal cancer with wild-type KRAS.
Author:	Kishiki, Tomokazu\|Ohnishi, Hiroaki\|Masaki, Tadahiko\|Ohtsuka, Kouki\|Ohkura, Yasuo\|Furuse, Jyunji\|Watanabe, Takashi\|Sugiyama, Masanori
PMID:	24500024

285.
Journal:	Cancer. 2014 May 15;120(10):1482-90.
Title:	Mutational analysis and clinical correlation of metastatic colorectal cancer.
Author:	Russo, Andrea L\|Borger, Darrell R\|Szymonifka, Jackie\|Ryan, David P\|Wo, Jennifer Y\|Blaszkowsky, Lawrence S\|Kwak, Eunice L\|Allen, Jill N\|Wadlow, Raymond C\|Zhu, Andrew X\|Murphy, Janet E\|Faris, Jason E\|Dias-Santagata, Dora\|Haigis, Kevin M\|Ellisen, Leif W\|Iafr
PMID:	24500602

286.
Journal:	Am J Surg Pathol. 2014 Jul;38(7):910-20.
Title:	SMARCB1 (INI1)-negative rhabdoid carcinomas of the gastrointestinal tract: clinicopathologic and molecular study of a highly aggressive variant with literature review.
Author:	Agaimy, Abbas\|Rau, Tilman T\|Hartmann, Arndt\|Stoehr, Robert
PMID:	24503755

287.
Journal:	Cancer Lett. 2014 Jun 1;347(2):204-11.
Title:	Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer.
Author:	Roper, Jatin\|Sinnamon, Mark J\|Coffee, Erin M\|Belmont, Peter\|Keung, Lily\|Georgeon-Richard, Larissa\|Wang, Wei Vivian\|Faber, Anthony C\|Yun, Jihye\|Yilmaz, Omer H\|Bronson, Roderick T\|Martin, Eric S\|Tsichlis, Philip N\|Hung, Kenneth E
PMID:	24576621

288.
Journal:	Int J Cancer. 2014 Oct 1;135(7):1586-95.
Title:	Methylation epigenotypes and genetic features in colorectal laterally spreading tumors.
Author:	Sakai, Eiji\|Ohata, Ken\|Chiba, Hideyuki\|Matsuhashi, Nobuyuki\|Doi, Noriteru\|Fukushima, Junichi\|Endo, Hiroki\|Takahashi, Hirokazu\|Tsuji, Shingo\|Yagi, Koichi\|Matsusaka, Keisuke\|Aburatani, Hiroyuki\|Nakajima, Atsushi\|Kaneda, Atsushi
PMID:	24590867

289.
Journal:	J Cancer Res Clin Oncol. 2014 May;140(5):737-48.
Title:	EGFR gene gain and PTEN protein expression are favorable prognostic factors in patients with KRAS wild-type metastatic colorectal cancer treated with cetuximab.
Author:	Razis, Evangelia\|Pentheroudakis, George\|Rigakos, George\|Bobos, Mattheos\|Kouvatseas, George\|Tzaida, Olympia\|Makatsoris, Thomas\|Papakostas, Pavlos\|Bai, Maria\|Goussia, Anna\|Samantas, Epaminontas\|Papamichael, Demetrios\|Romanidou, Ourania\|Efstratiou, Ioannis\|T
PMID:	24595598

290.
Journal:	Nihon Rinsho. 2014 Jan;72(1):29-34.
Title:	[Perspective of personalized (precise) cancer therapy based on predictive biomarkers].
Author:	Osera, Shozo\|Yoshino, Takayuki
PMID:	24597345

291.
Journal:	PLoS One. 2014 Mar 5;9(3):e90459.
Title:	Comparative genomic analysis of primary and synchronous metastatic colorectal cancers.
Author:	Lee, Sun Young\|Haq, Farhan\|Kim, Deokhoon\|Jun, Cui\|Jo, Hui-Jong\|Ahn, Sung-Min\|Lee, Won-Suk
PMID:	24599305

292.
Journal:	Z Gastroenterol. 2014 Mar;52(3):306-7.
Title:	[Aspirin and PIK3CA mutation in colorectal cancer].
Author:	Kirstein, M M\|Vogel, A
PMID:	24622874

293.
Journal:	Front Oncol. 2014 Mar 3;4:35.
Title:	PIK3CA in Colorectal Cancer.
Author:	Cathomas, Gieri
PMID:	24624362

294.
Journal:	Oncologist. 2014 Apr;19(4):336-43.
Title:	Profiling cancer gene mutations in clinical formalin-fixed, paraffin-embedded colorectal tumor specimens using targeted next-generation sequencing.
Author:	Zhang, Liangxuan\|Chen, Liangjing\|Sah, Sachin\|Latham, Gary J\|Patel, Rajesh\|Song, Qinghua\|Koeppen, Hartmut\|Tam, Rachel\|Schleifman, Erica\|Mashhedi, Haider\|Chalasani, Sreedevi\|Fu, Ling\|Sumiyoshi, Teiko\|Raja, Rajiv\|Forrest, William\|Hampton, Garret M\|Lackner, M
PMID:	24664487

295.
Journal:	PLoS Genet. 2014 Mar 27;10(3):e1004271.
Title:	Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing.
Author:	Mohan, Sumitra\|Heitzer, Ellen\|Ulz, Peter\|Lafer, Ingrid\|Lax, Sigurd\|Auer, Martina\|Pichler, Martin\|Gerger, Armin\|Eisner, Florian\|Hoefler, Gerald\|Bauernhofer, Thomas\|Geigl, Jochen B\|Speicher, Michael R
PMID:	24676216

296.
Journal:	J Clin Endocrinol Metab. 2014 Jul;99(7):E1163-72.
Title:	ZIC1 is a putative tumor suppressor in thyroid cancer by modulating major signaling pathways and transcription factor FOXO3a.
Author:	Qiang, Wei\|Zhao, Yuan\|Yang, Qi\|Liu, Wei\|Guan, Haixia\|Lv, Siqing\|Ji, Meiju\|Shi, Bingyin\|Hou, Peng
PMID:	24684457

297.
Journal:	JAMA Intern Med. 2014 May;174(5):732-9.
Title:	Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer.
Author:	Reimers, Marlies S\|Bastiaannet, Esther\|Langley, Ruth E\|van Eijk, Ronald\|van Vlierberghe, Ronald L P\|Lemmens, Valery E P\|van Herk-Sukel, Myrthe P P\|van Wezel, Tom\|Fodde, Riccardo\|Kuppen, Peter J K\|Morreau, Hans\|van de Velde, Cornelis J H\|Liefers, Gerrit Ja
PMID:	24687028

298.
Journal:	Ann Surg Oncol. 2014 Aug;21(8):2642-9.
Title:	The frequencies and clinical implications of mutations in 33 kinase-related genes in locally advanced rectal cancer: a pilot study.
Author:	Abdul-Jalil, Khairun I\|Sheehan, Katherine M\|Toomey, Sinead\|Schmid, Jasmin\|Prehn, Jochen\|O'Grady, Anthony\|Cummins, Robert\|O'Neill, Brian\|McNamara, Deborah A\|Deasy, Joseph\|Breathnach, Oscar\|Grogan, Liam\|Rogers, Ailin\|Doherty, Glen\|Winter, Des\|Ryan, John\|El-
PMID:	24700299

299.
Journal:	Dig Dis Sci. 2014 Sep;59(9):2255-63.
Title:	Genetic mechanisms in interval colon cancers.
Author:	Richter, James M\|Pino, Maria Simona\|Austin, Thomas R\|Campbell, Emily\|Szymonifka, Jackie\|Russo, Andrea L\|Hong, Theodore S\|Borger, Darrell\|Iafrate, A John\|Chung, Daniel C
PMID:	24705641

300.
Journal:	Rev Recent Clin Trials. 2014;9(1):8-12.
Title:	The Emerging Role of NRAS Mutations in Colorectal Cancer Patients Selected for Anti-EGFR Therapies.
Author:	Meriggi, Fausto\|Vermi, William\|Bertocchi, Paola\|Zaniboni, Alberto
PMID:	24758538

301.
Journal:	Future Oncol. 2014 Apr;10(5):713-23.
Title:	Pyrosequencing evaluation of low-frequency KRAS mutant alleles for EGF receptor therapy selection in metastatic colorectal carcinoma.
Author:	Natalicchio, Maria Iole\|Improta, Giuseppina\|Zupa, Angela\|Cursio, Olga Elisabetta\|Stampone, Emanuela\|Possidente, Luciana\|Teresa Gerardi, Assunta Maria\|Vita, Giulia\|Martini, Maurizio\|Cassano, Alessandra\|Piccoli, Claudia\|Romito, Sante\|Aieta, Michele\|Antonett
PMID:	24799053

302.
Journal:	Br J Cancer. 2014 May 27;110(11):2728-37.
Title:	Molecular patterns in deficient mismatch repair colorectal tumours: results from a French prospective multicentric biological and genetic study.
Author:	Etienne-Grimaldi, M-C\|Mahamat, A\|Chazal, M\|Laurent-Puig, P\|Olschwang, S\|Gaub, M-P\|Formento, J-L\|Formento, P\|Sudaka, A\|Boige, V\|Abderrahim-Ferkoune, A\|Benchimol, D\|Andre, T\|Houry, S\|Faucheron, J-L\|Letoublon, C\|Gilly, F-N\|Delpero, J-R\|Lasser, P\|Pradere, B\|P
PMID:	24800948

303.
Journal:	Oncol Rep. 2014 Jul;32(1):57-64.
Title:	Impact of genetic profiles on the efficacy of anti-EGFR antibodies in metastatic colorectal cancer with KRAS mutation.
Author:	Kishiki, Tomokazu\|Ohnishi, Hiroaki\|Masaki, Tadahiko\|Ohtsuka, Kouki\|Ohkura, Yasuo\|Furuse, Jyunji\|Sugiyama, Masanori\|Watanabe, Takashi
PMID:	24839940

304.
Journal:	Eur J Cancer. 2014 Jul;50(11):1964-72.
Title:	Comprehensive molecular characterisation of hereditary non-polyposis colorectal tumours with mismatch repair proficiency.
Author:	Bellido, Fernando\|Pineda, Marta\|Sanz-Pamplona, Rebeca\|Navarro, Matilde\|Nadal, Marga\|Lazaro, Conxi\|Blanco, Ignacio\|Moreno, Victor\|Capella, Gabriel\|Valle, Laura
PMID:	24841217

305.
Journal:	Ann Surg Oncol. 2014 Dec;21 Suppl 4:S680-6.
Title:	Clinical relevance of alterations in quantity and quality of plasma DNA in colorectal cancer patients: based on the mutation spectra detected in primary tumors.
Author:	Lin, Jen-Kou\|Lin, Pei-Ching\|Lin, Chien-Hsing\|Jiang, Jeng-Kai\|Yang, Shung-Haur\|Liang, Wen-Yi\|Chen, Wei-Shone\|Chang, Shih-Ching
PMID:	24841357

306.
Journal:	Am Soc Clin Oncol Educ Book. 2014:91-9.
Title:	The evolution of our molecular understanding of colorectal cancer: what we are doing now, what the future holds, and how tumor profiling is just the beginning.
Author:	Dienstmann, Rodrigo\|Salazar, Ramon\|Tabernero, Josep
PMID:	24857065

307.
Journal:	Med Oncol. 2014 Jul;31(7):16.
Title:	Mutations of KRAS and PIK3CA as independent predictors of distant metastases in colorectal cancer.
Author:	Zhu, Kunli\|Yan, Hongjiang\|Wang, Renben\|Zhu, Hui\|Meng, Xiangjiao\|Xu, Xiaoqing\|Dou, Xue\|Chen, Dong
PMID:	24861917

308.
Journal:	Cancer Sci. 2014 Aug;105(8):1002-7.
Title:	Clinical impact of c-MET expression and genetic mutational status in colorectal cancer patients after liver resection.
Author:	Shoji, Hirokazu\|Yamada, Yasuhide\|Taniguchi, Hirokazu\|Nagashima, Kengo\|Okita, Natsuko\|Takashima, Atsuo\|Honma, Yoshitaka\|Iwasa, Satoru\|Kato, Ken\|Hamaguchi, Tetsuya\|Shimada, Yasuhiro
PMID:	24863535

309.
Journal:	Mol Cancer. 2014 May 31;13:135.
Title:	Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review.
Author:	Imamura, Yu\|Lochhead, Paul\|Yamauchi, Mai\|Kuchiba, Aya\|Qian, Zhi Rong\|Liao, Xiaoyun\|Nishihara, Reiko\|Jung, Seungyoun\|Wu, Kana\|Nosho, Katsuhiko\|Wang, Yaoyu E\|Peng, Shouyong\|Bass, Adam J\|Haigis, Kevin M\|Meyerhardt, Jeffrey A\|Chan, Andrew T\|Fuchs, Charles S\|O
PMID:	24885062

310.
Journal:	Cancer Epidemiol Biomarkers Prev. 2014 Aug;23(8):1628-37.
Title:	Predicted 25(OH)D score and colorectal cancer risk according to vitamin D receptor expression.
Author:	Jung, Seungyoun\|Qian, Zhi Rong\|Yamauchi, Mai\|Bertrand, Kimberly A\|Fitzgerald, Kathryn C\|Inamura, Kentaro\|Kim, Sun A\|Mima, Kosuke\|Sukawa, Yasutaka\|Zhang, Xuehong\|Wang, Molin\|Smith-Warner, Stephanie A\|Wu, Kana\|Fuchs, Charles S\|Chan, Andrew T\|Giovannucci, Ed
PMID:	24920642

311.
Journal:	Oncotarget. 2014 May 30;5(10):2999-3011.
Title:	WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear beta-Catenin depend on active PI3K signaling.
Author:	Ormanns, Steffen\|Neumann, Jens\|Horst, David\|Kirchner, Thomas\|Jung, Andreas
PMID:	24930890

312.
Journal:	Oncol Lett. 2014 Jun;7(6):1761-1766.
Title:	'Druggable' alterations detected by Ion Torrent in metastatic colorectal cancer patients.
Author:	Fang, Weijia\|Radovich, Milan\|Zheng, Yulong\|Fu, Cai-Yun\|Zhao, Peng\|Mao, Chengyu\|Zheng, Yi\|Zheng, Shusen
PMID:	24932229

313.
Journal:	Am J Gastroenterol. 2014 Aug;109(8):1205-14.
Title:	Progress and opportunities in molecular pathological epidemiology of colorectal premalignant lesions.
Author:	Lochhead, Paul\|Chan, Andrew T\|Giovannucci, Edward\|Fuchs, Charles S\|Wu, Kana\|Nishihara, Reiko\|O'Brien, Michael\|Ogino, Shuji
PMID:	24935274

314.
Journal:	Ann Oncol. 2014 Sep;25(9):1756-61.
Title:	Clinical activity of FOLFIRI plus cetuximab according to extended gene mutation status by next-generation sequencing: findings from the CAPRI-GOIM trial.
Author:	Ciardiello, F\|Normanno, N\|Maiello, E\|Martinelli, E\|Troiani, T\|Pisconti, S\|Giuliani, F\|Barone, C\|Carteni, G\|Rachiglio, A M\|Montesarchio, V\|Tonini, G\|Rizzi, D\|Cinieri, S\|Bordonaro, R\|Febbraro, A\|De Vita, F\|Orditura, M\|Fenizia, F\|Lambiase, M\|Rinaldi, A\|Tatan
PMID:	24942275

315.
Journal:	BMC Med Genomics. 2014 Jun 18;7:36.
Title:	Whole genome sequencing reveals potential targets for therapy in patients with refractory KRAS mutated metastatic colorectal cancer.
Author:	Shanmugam, Vijayalakshmi\|Ramanathan, Ramesh K\|Lavender, Nicole A\|Sinari, Shripad\|Chadha, Manpreet\|Liang, Winnie S\|Kurdoglu, Ahmet\|Izatt, Tyler\|Christoforides, Alexis\|Benson, Hollie\|Phillips, Lori\|Baker, Angela\|Murray, Christopher\|Hostetter, Galen\|Von Hoff
PMID:	24943349

316.
Journal:	Clin Cancer Res. 2014 Aug 15;20(16):4251-61.
Title:	Phase I expansion and pharmacodynamic study of the oral MEK inhibitor RO4987655 (CH4987655) in selected patients with advanced cancer with RAS-RAF mutations.
Author:	Zimmer, Lisa\|Barlesi, Fabrice\|Martinez-Garcia, Maria\|Dieras, Veronique\|Schellens, Jan H M\|Spano, Jean-Philippe\|Middleton, Mark R\|Calvo, Emiliano\|Paz-Ares, Luiz\|Larkin, James\|Pacey, Simon\|Venturi, Miro\|Kraeber-Bodere, Francoise\|Tessier, Jean J L\|Eberhardt,
PMID:	24947927

317.
Journal:	Int J Mol Epidemiol Genet. 2014 May 29;5(2):100-11. eCollection 2014.
Title:	Influence of CHIEF pathway genes on gene expression: a pathway approach to functionality.
Author:	Slattery, Martha L\|Lundgreen, Abbie\|Mullany, Lila E\|Penney, Rosalind B\|Wolff, Roger K
PMID:	24959314

318.
Journal:	Oncotarget. 2014 Jul 15;5(13):5138-52.
Title:	ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells.
Author:	Lee, Hyunji\|Lee, Hyunjung\|Chin, Hyunjung\|Kim, Kyoungmi\|Lee, Daekee
PMID:	24970817

319.
Journal:	Ann Surg Oncol. 2014 Dec;21(13):4164-73.
Title:	SMO expression in colorectal cancer: associations with clinical, pathological, and molecular features.
Author:	Li, Tingting\|Liao, Xiaoyun\|Lochhead, Paul\|Morikawa, Teppei\|Yamauchi, Mai\|Nishihara, Reiko\|Inamura, Kentaro\|Kim, Sun A\|Mima, Kosuke\|Sukawa, Yasutaka\|Kuchiba, Aya\|Imamura, Yu\|Baba, Yoshifumi\|Shima, Kaori\|Meyerhardt, Jeffrey A\|Chan, Andrew T\|Fuchs, Charles S
PMID:	25023548

320.
Journal:	Inflamm Bowel Dis. 2014 Sep;20(9):1584-92.
Title:	Small bowel adenocarcinomas complicating Crohn's disease are associated with dysplasia: a pathological and molecular study.
Author:	Svrcek, Magali\|Piton, Gael\|Cosnes, Jacques\|Beaugerie, Laurent\|Vermeire, Severine\|Geboes, Karel\|Lemoine, Antoinette\|Cervera, Pascale\|El-Murr, Nizar\|Dumont, Sylvie\|Scriva, Aurelie\|Lascols, Olivier\|Ardizzone, Sandro\|Fociani, Paolo\|Savoye, Guillaume\|Le Pessot
PMID:	25029614

321.
Journal:	Biomed Res Int. 2014;2014:591867.
Title:	Current approaches for predicting a lack of response to anti-EGFR therapy in KRAS wild-type patients.
Author:	Er, Tze-Kiong\|Chen, Chih-Chieh\|Bujanda, Luis\|Herreros-Villanueva, Marta
PMID:	25032217

322.
Journal:	Med Oncol. 2014 Sep;31(9):124.
Title:	Molecular spectrum of KRAS, BRAF, and PIK3CA gene mutation: determination of frequency, distribution pattern in Indian colorectal carcinoma.
Author:	Bisht, Swati\|Ahmad, Firoz\|Sawaimoon, Satyakam\|Bhatia, Simi\|Das, Bibhu Ranjan
PMID:	25073438

323.
Journal:	PLoS One. 2014 Aug 1;9(8):e103159.
Title:	Sporadic early-onset colorectal cancer is a specific sub-type of cancer: a morphological, molecular and genetics study.
Author:	Kirzin, Sylvain\|Marisa, Laetitia\|Guimbaud, Rosine\|De Reynies, Aurelien\|Legrain, Michele\|Laurent-Puig, Pierre\|Cordelier, Pierre\|Pradere, Bernard\|Bonnet, Delphine\|Meggetto, Fabienne\|Portier, Guillaume\|Brousset, Pierre\|Selves, Janick
PMID:	25083765

324.
Journal:	PLoS One. 2014 Aug 5;9(8):e103822.
Title:	Distinct molecular features of different macroscopic subtypes of colorectal neoplasms.
Author:	Konda, Kenichi\|Konishi, Kazuo\|Yamochi, Toshiko\|Ito, Yoichi M\|Nozawa, Hisako\|Tojo, Masayuki\|Shinmura, Kensuke\|Kogo, Mari\|Katagiri, Atsushi\|Kubota, Yutaro\|Muramoto, Takashi\|Yano, Yuichiro\|Kobayashi, Yoshiya\|Kihara, Toshihiro\|Tagawa, Teppei\|Makino, Reiko\|Tak
PMID:	25093594

325.
Journal:	Cancer Discov. 2014 Oct;4(10):1182-1197.
Title:	Development of siRNA payloads to target KRAS-mutant cancer.
Author:	Yuan, Tina L\|Fellmann, Christof\|Lee, Chih-Shia\|Ritchie, Cayde D\|Thapar, Vishal\|Lee, Liam C\|Hsu, Dennis J\|Grace, Danielle\|Carver, Joseph O\|Zuber, Johannes\|Luo, Ji\|McCormick, Frank\|Lowe, Scott W
PMID:	25100204

326.
Journal:	World J Gastroenterol. 2014 Aug 7;20(29):10050-61.
Title:	IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions.
Author:	Naito, Takafumi\|Nosho, Katsuhiko\|Ito, Miki\|Igarashi, Hisayoshi\|Mitsuhashi, Kei\|Yoshii, Shinji\|Aoki, Hironori\|Nomura, Masafumi\|Sukawa, Yasutaka\|Yamamoto, Eiichiro\|Adachi, Yasushi\|Takahashi, Hiroaki\|Hosokawa, Masao\|Fujita, Masahiro\|Takenouchi, Toshinao\|Maru
PMID:	25110432

327.
Journal:	Br J Cancer. 2014 Nov 25;111(11):2172-9.
Title:	Relationship between aspirin use after diagnosis of colorectal cancer and patient survival: a meta-analysis of observational studies.
Author:	Ye, X-F\|Wang, J\|Shi, W-T\|He, J
PMID:	25180765

328.
Journal:	J Natl Cancer Inst. 2014 Sep 4;106(9). pii: dju195.
Title:	Tumor LINE-1 methylation level and microsatellite instability in relation to colorectal cancer prognosis.
Author:	Inamura, Kentaro\|Yamauchi, Mai\|Nishihara, Reiko\|Lochhead, Paul\|Qian, Zhi Rong\|Kuchiba, Aya\|Kim, Sun A\|Mima, Kosuke\|Sukawa, Yasutaka\|Jung, Seungyoun\|Zhang, Xuehong\|Wu, Kana\|Cho, Eunyoung\|Chan, Andrew T\|Meyerhardt, Jeffrey A\|Harris, Curtis C\|Fuchs, Charles
PMID:	25190725

329.
Journal:	Am Surg. 2014 Sep;80(9):873-7.
Title:	KRAS and PIK3CA mutation frequencies in patient-derived xenograft models of pancreatic and colorectal cancer are reflective of patient tumors and stable across passages.
Author:	Tignanelli, Christopher J\|Herrera Loeza, Silvia G\|Yeh, Jen Jen
PMID:	25197873

330.
Journal:	Biomed Res Int. 2014;2014:568693.
Title:	Biological and molecular effects of small molecule kinase inhibitors on low-passage human colorectal cancer cell lines.
Author:	Lange, Falko\|Franz, Benjamin\|Maletzki, Claudia\|Linnebacher, Michael\|Huhns, Maja\|Jaster, Robert
PMID:	25309914

331.
Journal:	Onco Targets Ther. 2014 Oct 4;7:1817-28.
Title:	Colorectal cancer in Chinese patients: current and emerging treatment options.
Author:	Li, Leung\|Ma, Brigette By
PMID:	25336973

332.
Journal:	Int J Clin Exp Pathol. 2014 Aug 15;7(9):5927-39. eCollection 2014.
Title:	Comparison of neuroendocrine differentiation and KRAS/NRAS/BRAF/PIK3CA/TP53 mutation status in primary and metastatic colorectal cancer.
Author:	Kleist, Britta\|Kempa, Marcel\|Novy, Michael\|Oberkanins, Christian\|Xu, Li\|Li, Guojun\|Loland, Christiane\|Poetsch, Micaela
PMID:	25337237

333.
Journal:	BMC Cancer. 2014 Nov 3;14:802.
Title:	BRAF V600E mutation and KRAS codon 13 mutations predict poor survival in Chinese colorectal cancer patients.
Author:	Chen, Jing\|Guo, Fang\|Shi, Xin\|Zhang, Lihua\|Zhang, Aifeng\|Jin, Hui\|He, Youji
PMID:	25367198

334.
Journal:	Neoplasia. 2014 Oct 23;16(10):845-60.
Title:	Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation.
Author:	Grasso, Silvina\|Tristante, Elena\|Saceda, Miguel\|Carbonell, Pablo\|Mayor-Lopez, Leticia\|Carballo-Santana, Mar\|Carrasco-Garcia, Estefania\|Rocamora-Reverte, Lourdes\|Garcia-Morales, Pilar\|Carballo, Fernando\|Ferragut, Jose A\|Martinez-Lacaci, Isabel
PMID:	25379021

335.
Journal:	Cancer Epidemiol Biomarkers Prev. 2014 Dec;23(12):2965-70.
Title:	Programmed cell death 1 (PD-1) and its ligand (PD-L1) in common cancers and their correlation with molecular cancer type.
Author:	Gatalica, Zoran\|Snyder, Carrie\|Maney, Todd\|Ghazalpour, Anatole\|Holterman, Daniel A\|Xiao, Nianqing\|Overberg, Peggy\|Rose, Inga\|Basu, Gargi D\|Vranic, Semir\|Lynch, Henry T\|Von Hoff, Daniel D\|Hamid, Omid
PMID:	25392179

336.
Journal:	Clin Colorectal Cancer. 2014 Dec;13(4):207-12.
Title:	Ganetespib, a novel Hsp90 inhibitor in patients with KRAS mutated and wild type, refractory metastatic colorectal cancer.
Author:	Cercek, Andrea\|Shia, Jinru\|Gollub, Marc\|Chou, Joanne F\|Capanu, Marinela\|Raasch, Pamela\|Reidy-Lagunes, Diane\|Proia, David A\|Vakiani, Efsevia\|Solit, David B\|Saltz, Leonard B
PMID:	25444464

337.
Journal:	Cell Death Dis. 2014 Dec 11;5:e1570.
Title:	XIAP-targeting drugs re-sensitize PIK3CA-mutated colorectal cancer cells for death receptor-induced apoptosis.
Author:	Ehrenschwender, M\|Bittner, S\|Seibold, K\|Wajant, H
PMID:	25501831

338.
Journal:	Medicine (Baltimore). 2014 Dec;93(28):e298.
Title:	Genomic profiling of patient-derived colon cancer xenograft models.
Author:	Lee, Won-Suk\|Kim, Hye-Youn\|Seok, Jae Yeon\|Jang, Ho Hee\|Park, Yeon Ho\|Kim, So-Young\|Shin, Dong Bok\|Hong, Suntaek
PMID:	25526474

339.
Journal:	PLoS One. 2014 Dec 26;9(12):e116169.
Title:	The influence of the CHIEF pathway on colorectal cancer-specific mortality.
Author:	Slattery, Martha L\|Lundgreen, Abbie
PMID:	25541970

340.
Journal:	Int J Clin Exp Pathol. 2014 Oct 15;7(11):8295-303. eCollection 2014.
Title:	PIK3CA and PIK3CB expression and relationship with multidrug resistance in colorectal carcinoma.
Author:	Wen, Feifei\|He, Shuang\|Sun, Chenbo\|Li, Tangyue\|Wu, Shuhua
PMID:	25550888

341.
Journal:	Pol J Pathol. 2014 Dec;65(4):257-66.
Title:	Molecular pathology of colorectal cancer.
Author:	Bosman, Ft\|Yan, P
PMID:	25693079

342.
Journal:	Gut. 2015 Sep;64(9):1419-25.
Title:	Aspirin use after diagnosis but not prediagnosis improves established colorectal cancer survival: a meta-analysis.
Author:	Li, Peiwei\|Wu, Han\|Zhang, Honghe\|Shi, Yu\|Xu, Jinming\|Ye, Yao\|Xia, Dajing\|Yang, Jun\|Cai, Jianting\|Wu, Yihua
PMID:	25239119

343.
Journal:	Int J Cancer. 2015 Apr 15;136(8):1967-75.
Title:	Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model.
Author:	Song, Eun-Kee\|Tai, W M\|Messersmith, Wells A\|Bagby, Stacey\|Purkey, Alicia\|Quackenbush, Kevin S\|Pitts, Todd M\|Wang, Guoliang\|Blatchford, Patrick\|Yahn, Rachel\|Kaplan, Jeffrey\|Tan, Aik Choon\|Atreya, Chloe E\|Eckhardt, Gail\|Kelley, Robin K\|Venook, Alan\|Kwak, Eu
PMID:	25242168

344.
Journal:	Cancer. 2015 Jan 1;121(1):34-42.
Title:	Identification of novel mutations by exome sequencing in African American colorectal cancer patients.
Author:	Ashktorab, Hassan\|Daremipouran, Mohammad\|Devaney, Joe\|Varma, Sudhir\|Rahi, Hamed\|Lee, Edward\|Shokrani, Babak\|Schwartz, Russell\|Nickerson, Michael L\|Brim, Hassan
PMID:	25250560

345.
Journal:	Ann Surg Oncol. 2015 Apr;22(4):1226-1235.
Title:	Prognostic significance and molecular features of signet-ring cell and mucinous components in colorectal carcinoma.
Author:	Inamura, Kentaro\|Yamauchi, Mai\|Nishihara, Reiko\|Kim, Sun A\|Mima, Kosuke\|Sukawa, Yasutaka\|Li, Tingting\|Yasunari, Mika\|Zhang, Xuehong\|Wu, Kana\|Meyerhardt, Jeffrey A\|Fuchs, Charles S\|Harris, Curtis C\|Qian, Zhi Rong\|Ogino, Shuji
PMID:	25326395

346.
Journal:	Tumour Biol. 2015 Feb;36(2):1091-7.
Title:	Combine MEK inhibition with PI3K/mTOR inhibition exert inhibitory tumor growth effect on KRAS and PIK3CA mutation CRC xenografts due to reduced expression of VEGF and matrix metallopeptidase-9.
Author:	E, Jifu\|Xing, Junjie\|Gong, Haifeng\|He, Jian\|Zhang, Wei
PMID:	25326806

347.
Journal:	J Cell Mol Med. 2015 Feb;19(2):408-17.
Title:	Role of p38 MAPK in enhanced human cancer cells killing by the combination of aspirin and ABT-737.
Author:	Zhang, Chong\|Shi, Jing\|Mao, Shi-ying\|Xu, Ya-si\|Zhang, Dan\|Feng, Lin-yi\|Zhang, Bo\|Yan, You-you\|Wang, Si-cong\|Pan, Jian-ping\|Yang, You-ping\|Lin, Neng-ming
PMID:	25388762

348.
Journal:	Biochim Biophys Acta. 2015 Jan;1855(1):104-21.
Title:	Portrait of the PI3K/AKT pathway in colorectal cancer.
Author:	Danielsen, Stine Aske\|Eide, Peter Wold\|Nesbakken, Arild\|Guren, Tormod\|Leithe, Edward\|Lothe, Ragnhild A
PMID:	25450577

349.
Journal:	Cancer. 2015 Apr 15;121(8):1195-203.
Title:	RAS mutations affect pattern of metastatic spread and increase propensity for brain metastasis in colorectal cancer.
Author:	Yaeger, Rona\|Cowell, Elizabeth\|Chou, Joanne F\|Gewirtz, Alexandra N\|Borsu, Laetitia\|Vakiani, Efsevia\|Solit, David B\|Rosen, Neal\|Capanu, Marinela\|Ladanyi, Marc\|Kemeny, Nancy
PMID:	25491172

350.
Journal:	Int J Surg. 2015 Jan;13:272-9.
Title:	MicroRNAs associated with initiation and progression of colonic polyp: a feasibility study.
Author:	Aslam, Muhammad Imran\|Hussein, Samir\|West, Kevin\|Singh, Baljit\|Jameson, John Stuart\|Pringle, James Howard
PMID:	25496852

351.
Journal:	J Mol Diagn. 2015 Mar;17(2):193-200.
Title:	Target-enriched next-generation sequencing reveals differences between primary and secondary ovarian tumors in formalin-fixed, paraffin-embedded tissue.
Author:	Crobach, Stijn\|Ruano, Dina\|van Eijk, Ronald\|Fleuren, Gert Jan\|Minderhout, Ivonne\|Snowdowne, Ronelle\|Tops, Carli\|van Wezel, Tom\|Morreau, Hans
PMID:	25545608

352.
Journal:	Acta Oncol. 2015 Apr;54(4):487-92.
Title:	Impact of regular aspirin use on overall and cancer-specific survival in patients with colorectal cancer harboring a PIK3CA mutation.
Author:	Kothari, Nishi\|Kim, Richard\|Jorissen, Robert N\|Desai, Jayesh\|Tie, Jeanne\|Wong, Hui-Li\|Faragher, Ian\|Jones, Ian\|Day, Fiona L\|Li, Shan\|Sakthinandeswaren, Anuratha\|Palmieri, Michelle\|Lipton, Lara\|Schell, Michael\|Teer, Jamie K\|Shibata, David\|Yeatman, Timothy\|
PMID:	25549537

353.
Journal:	Cancer Lett. 2015 Apr 1;359(1):47-56.
Title:	Quinazoline based small molecule exerts potent tumour suppressive properties by inhibiting PI3K/Akt/FoxO3a signalling in experimental colon cancer.
Author:	Qazi, Asif Khurshid\|Hussain, Aashiq\|Khan, Saima\|Aga, Mushtaq A\|Behl, Akanksha\|Ali, Shakir\|Singh, Shashank Kumar\|Taneja, Subhash Chandra\|Shah, Bhahwal Ali\|Saxena, Ajit Kumar\|Mondhe, Dilip Manikrao\|Hamid, Abid
PMID:	25554016

354.
Journal:	PLoS One. 2015 Jan 24;10(1):e0116753.
Title:	A pathway-centric survey of somatic mutations in Chinese patients with colorectal carcinomas.
Author:	Ling, Chao\|Wang, Lin\|Wang, Zheng\|Xu, Luming\|Sun, Lifang\|Yang, Hui\|Li, Wei-Dong\|Wang, Kai
PMID:	25617745

355.
Journal:	Clin Cancer Res. 2015 May 1;21(9):2157-66.
Title:	Emergence of Multiple EGFR Extracellular Mutations during Cetuximab Treatment in Colorectal Cancer.
Author:	Arena, Sabrina\|Bellosillo, Beatriz\|Siravegna, Giulia\|Martinez, Alejandro\|Canadas, Israel\|Lazzari, Luca\|Ferruz, Noelia\|Russo, Mariangela\|Misale, Sandra\|Gonzalez, Iria\|Iglesias, Mar\|Gavilan, Elena\|Corti, Giorgio\|Hobor, Sebastijan\|Crisafulli, Giovanni\|Salido
PMID:	25623215

356.
Journal:	Biochem Biophys Res Commun. 2015 Feb 27;458(1):52-6.
Title:	Inter- and intra-tumor profiling of multi-regional colon cancer and metastasis.
Author:	Kogita, Akihiro\|Yoshioka, Yasumasa\|Sakai, Kazuko\|Togashi, Yosuke\|Sogabe, Shunsuke\|Nakai, Takuya\|Okuno, Kiyotaka\|Nishio, Kazuto
PMID:	25623536

357.
Journal:	Sci Rep. 2015 Feb 2;5:8065.
Title:	Concordant analysis of KRAS, BRAF, PIK3CA mutations, and PTEN expression between primary colorectal cancer and matched metastases.
Author:	Mao, Chen\|Wu, Xin-Yin\|Yang, Zu-Yao\|Threapleton, Diane Erin\|Yuan, Jin-Qiu\|Yu, Yuan-Yuan\|Tang, Jin-Ling
PMID:	25639985

358.
Journal:	Cancer Med. 2015 Mar;4(3):371-82.
Title:	PIK3CA mutations predict recurrence in localized microsatellite stable colon cancer.
Author:	Manceau, Gilles\|Marisa, Laetitia\|Boige, Valerie\|Duval, Alex\|Gaub, Marie-Pierre\|Milano, Gerard\|Selves, Janick\|Olschwang, Sylviane\|Jooste, Valerie\|le Legrain, Miche\|Lecorre, Delphine\|Guenot, Dominique\|Etienne-Grimaldi, Marie-Christine\|Kirzin, Sylvain\|Martin
PMID:	25641861

359.
Journal:	Oncol Lett. 2015 Mar;9(3):1432-1438.
Title:	EGFR methylation and outcome of patients with advanced colorectal cancer treated with cetuximab.
Author:	Chiadini, Elisa\|Scarpi, Emanuela\|Passardi, Alessandro\|Calistri, Daniele\|Valgiusti, Martina\|Saragoni, Luca\|Zoli, Wainer\|Amadori, Dino\|Ulivi, Paola
PMID:	25663927

360.
Journal:	Hum Pathol. 2015 Apr;46(4):507-13.
Title:	Novel molecular insights from routine genotyping of colorectal carcinomas.
Author:	Stachler, Matthew D\|Rinehart, Elizabeth\|Lindeman, Neal\|Odze, Robert\|Srivastava, Amitabh
PMID:	25683705

361.
Journal:	Br J Cancer. 2015 Mar 17;112(6):1088-97.
Title:	Cytokine profile and prognostic significance of high neutrophil-lymphocyte ratio in colorectal cancer.
Author:	Chen, Z-Y\|Raghav, K\|Lieu, C H\|Jiang, Z-Q\|Eng, C\|Vauthey, J-N\|Chang, G J\|Qiao, W\|Morris, J\|Hong, D\|Hoff, P\|Tran, H\|Menter, D G\|Heymach, J\|Overman, M\|Kopetz, S
PMID:	25688736

362.
Journal:	Clin Cancer Res. 2015 Jun 1;21(11):2644-51.
Title:	Hotspot mutation panel testing reveals clonal evolution in a study of 265 paired primary and metastatic tumors.
Author:	Goswami, Rashmi S\|Patel, Keyur P\|Singh, Rajesh R\|Meric-Bernstam, Funda\|Kopetz, E Scott\|Subbiah, Vivek\|Alvarez, Ricardo H\|Davies, Michael A\|Jabbar, Kausar J\|Roy-Chowdhuri, Sinchita\|Lazar, Alexander J\|Medeiros, L Jeffrey\|Broaddus, Russell R\|Luthra, Rajyalak
PMID:	25695693

363.
Journal:	Nat Med. 2015 Mar;21(3):256-62.
Title:	Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.
Author:	Matano, Mami\|Date, Shoichi\|Shimokawa, Mariko\|Takano, Ai\|Fujii, Masayuki\|Ohta, Yuki\|Watanabe, Toshiaki\|Kanai, Takanori\|Sato, Toshiro
PMID:	25706875

364.
Journal:	Cancer Res. 2015 Apr 15;75(8):1560-6.
Title:	Evaluating patient-derived colorectal cancer xenografts as preclinical models by comparison with patient clinical data.
Author:	Nunes, Manoel\|Vrignaud, Patricia\|Vacher, Sophie\|Richon, Sophie\|Lievre, Astrid\|Cacheux, Wulfran\|Weiswald, Louis-Bastien\|Massonnet, Gerald\|Chateau-Joubert, Sophie\|Nicolas, Andre\|Dib, Colette\|Zhang, Weidong\|Watters, James\|Bergstrom, Donald\|Roman-Roman, Sergi
PMID:	25712343

365.
Journal:	Mol Cancer Res. 2015 Jun;13(6):1003-8.
Title:	AKT1 E17K in Colorectal Carcinoma Is Associated with BRAF V600E but Not MSI-H Status: A Clinicopathologic Comparison to PIK3CA Helical and Kinase Domain Mutants.
Author:	Hechtman, Jaclyn F\|Sadowska, Justyna\|Huse, Jason T\|Borsu, Laetitia\|Yaeger, Rona\|Shia, Jinru\|Vakiani, Efsevia\|Ladanyi, Marc\|Arcila, Maria E
PMID:	25714871

366.
Journal:	Br J Cancer. 2015 Mar 17;112(6):963-70.
Title:	Correlation of extended RAS and PIK3CA gene mutation status with outcomes from the phase III AGITG MAX STUDY involving capecitabine alone or in combination with bevacizumab plus or minus mitomycin C in advanced colorectal cancer.
Author:	Price, T J\|Bruhn, M A\|Lee, C K\|Hardingham, J E\|Townsend, A R\|Mann, K P\|Simes, J\|Weickhardt, A\|Wrin, J W\|Wilson, K\|Gebski, V\|Van Hazel, G\|Robinson, B\|Cunningham, D\|Tebbutt, N C
PMID:	25742472

367.
Journal:	Am J Surg Pathol. 2015 Aug;39(8):1140-7.
Title:	Distinctive Spatiotemporal Stability of Somatic Mutations in Metastasized Microsatellite-stable Colorectal Cancer.
Author:	Jesinghaus, Moritz\|Wolf, Thomas\|Pfarr, Nicole\|Muckenhuber, Alexander\|Ahadova, Aysel\|Warth, Arne\|Goeppert, Benjamin\|Sers, Christine\|Kloor, Matthias\|Endris, Volker\|Stenzinger, Albrecht\|Weichert, Wilko
PMID:	25786087

368.
Journal:	Oncotarget. 2015 Mar 30;6(9):7209-20.
Title:	Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis.
Author:	Mitsuhashi, Kei\|Nosho, Katsuhiko\|Sukawa, Yasutaka\|Matsunaga, Yasutaka\|Ito, Miki\|Kurihara, Hiroyoshi\|Kanno, Shinichi\|Igarashi, Hisayoshi\|Naito, Takafumi\|Adachi, Yasushi\|Tachibana, Mami\|Tanuma, Tokuma\|Maguchi, Hiroyuki\|Shinohara, Toshiya\|Hasegawa, Tadashi\|I
PMID:	25797243

369.
Journal:	Mol Med Rep. 2015 Jul;12(1):1219-24.
Title:	Identification of KRAS and PIK3CA but not BRAF mutations in patients with gastric cancer.
Author:	Lu, Weipeng\|Wei, Hong\|Li, Mei\|Wang, Hai\|Liu, Lina\|Zhang, Qiuping\|Liu, Lisha\|Lu, Shen
PMID:	25815786

370.
Journal:	Biomed Res Int. 2015;2015:373252.
Title:	A functional variant at miR-520a binding site in PIK3CA alters susceptibility to colorectal cancer in a Chinese Han population.
Author:	Ding, Lifang\|Jiang, Zao\|Chen, Qiaoyun\|Qin, Rong\|Fang, Yue\|Li, Hao
PMID:	25834816

371.
Journal:	Cancer Biomark. 2015;15(4):397-403.
Title:	Polymorphic GT dinucleotide repeat in the PIK3CA gene and risk of colorectal cancer.
Author:	Parsafar, Soha\|Hematti, Simin\|Ghorbani, Fateme\|Safari, Forousan\|Tavassoli, Manoochehr
PMID:	25835181

372.
Journal:	Clin Cancer Res. 2015 Jul 1;21(13):2975-83.
Title:	Primary and Acquired Resistance of Colorectal Cancer to Anti-EGFR Monoclonal Antibody Can Be Overcome by Combined Treatment of Regorafenib with Cetuximab.
Author:	Napolitano, Stefania\|Martini, Giulia\|Rinaldi, Barbara\|Martinelli, Erika\|Donniacuo, Maria\|Berrino, Liberato\|Vitagliano, Donata\|Morgillo, Floriana\|Barra, Giusy\|De Palma, Raffaele\|Merolla, Francesco\|Ciardiello, Fortunato\|Troiani, Teresa
PMID:	25838391

373.
Journal:	Ann Oncol. 2015 Aug;26(8):1710-4.
Title:	Heterogeneity of KRAS, NRAS, BRAF and PIK3CA mutations in metastatic colorectal cancer and potential effects on therapy in the CAPRI GOIM trial.
Author:	Normanno, N\|Rachiglio, A M\|Lambiase, M\|Martinelli, E\|Fenizia, F\|Esposito, C\|Roma, C\|Troiani, T\|Rizzi, D\|Tatangelo, F\|Botti, G\|Maiello, E\|Colucci, G\|Ciardiello, F
PMID:	25851630

374.
Journal:	BMC Cancer. 2015 Mar 14;15:125.
Title:	Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer.
Author:	Birgisson, Helgi\|Edlund, Karolina\|Wallin, Ulrik\|Pahlman, Lars\|Kultima, Hanna Goransson\|Mayrhofer, Markus\|Micke, Patrick\|Isaksson, Anders\|Botling, Johan\|Glimelius, Bengt\|Sundstrom, Magnus
PMID:	25884297

375.
Journal:	J Transl Med. 2015 Feb 12;13:57.
Title:	Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib.
Author:	Wong, Andrea Li Ann\|Lim, Joline Si Jing\|Sinha, Arvind\|Gopinathan, Anil\|Lim, Robert\|Tan, Chee-Seng\|Soh, Thomas\|Venkatesh, Sudhakar\|Titin, Christina\|Sapari, Nur Sabrina\|Lee, Soo-Chin\|Yong, Wei-Peng\|Tan, David Shao Ping\|Pang, Brendan\|Wang, Ting-Ting\|Zee, Yin
PMID:	25889309

376.
Journal:	Acta Oncol. 2015 Nov;54(10):1747-53.
Title:	Neoadjuvant chemotherapy in locally advanced colon cancer. A phase II trial.
Author:	Jakobsen, Anders\|Andersen, Fahimeh\|Fischer, Anders\|Jensen, Lars H\|Jorgensen, Jens C R\|Larsen, Ole\|Lindebjerg, Jan\|Ploen, John\|Rafaelsen, Soren R\|Vilandt, Jesper
PMID:	25920359

377.
Journal:	J Transl Med. 2015 May 7;13:140.
Title:	Prospective study of a molecular selection profile for RAS wild type colorectal cancer patients receiving irinotecan-cetuximab.
Author:	Giampieri, Riccardo\|Mandolesi, Alessandra\|Abouelkhair, Khaled M\|Loretelli, Cristian\|Del Prete, Michela\|Faloppi, Luca\|Maristella, Bianconi\|Ibrahim, Ezzeldin M\|Scarpelli, Marina\|Cascinu, Stefano\|Scartozzi, Mario
PMID:	25943333

378.
Journal:	Am J Cancer Res. 2015 Jan 15;5(2):674-88. eCollection 2015.
Title:	A specific KRAS codon 13 mutation is an independent predictor for colorectal cancer metachronous distant metastases.
Author:	Feng, Qingyang\|Liang, Li\|Ren, Li\|Chen, Jingwen\|Wei, Ye\|Chang, Wenju\|Zhu, Dexiang\|Lin, Qi\|Zheng, Peng\|Xu, Jianmin
PMID:	25973306

379.
Journal:	Eur J Cancer. 2015 Jul;51(11):1405-14.
Title:	Location of colon cancer (right-sided versus left-sided) as a prognostic factor and a predictor of benefit from cetuximab in NCIC CO.17.
Author:	Brule, S Y\|Jonker, D J\|Karapetis, C S\|O'Callaghan, C J\|Moore, M J\|Wong, R\|Tebbutt, N C\|Underhill, Cr\|Yip, D\|Zalcberg, J R\|Tu, D\|Goodwin, R A
PMID:	25979833

380.
Journal:	Am Soc Clin Oncol Educ Book. 2015:e149-56.
Title:	Overcoming Resistance to Anti-EGFR Therapy in Colorectal Cancer.
Author:	Dienstmann, Rodrigo\|Salazar, Ramon\|Tabernero, Josep
PMID:	25993166

381.
Journal:	Cancer Epidemiol Biomarkers Prev. 2015 Jul;24(7):1046-51.
Title:	PIK3CA Somatic Mutation Status in Relation to Patient and Tumor Factors in Racial/Ethnic Minorities with Colorectal Cancer.
Author:	Phipps, Amanda I\|Ahnen, Dennis J\|Cheng, Iona\|Newcomb, Polly A\|Win, Aung Ko\|Burnett, Terrilea
PMID:	25994739

382.
Journal:	Rev Med Chil. 2015 Mar;143(3):310-9.
Title:	[Molecular analysis of sporadic colon cancer].
Author:	Hurtado, Claudia\|Wielandt, Ana Maria\|Zarate, Alejandro J\|Kronberg, Udo\|Castro, Magdalena\|Yamagiwa, Ken\|Ito, Takashi\|Eishi, Yoshinobu\|Contreras, Luis\|Lopez-Kostner, Francisco
PMID:	26005817

383.
Journal:	PLoS One. 2015 May 26;10(5):e0127146.
Title:	Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.
Author:	Betge, Johannes\|Kerr, Grainne\|Miersch, Thilo\|Leible, Svenja\|Erdmann, Gerrit\|Galata, Christian L\|Zhan, Tianzuo\|Gaiser, Timo\|Post, Stefan\|Ebert, Matthias P\|Horisberger, Karoline\|Boutros, Michael
PMID:	26010451

384.
Journal:	Clin Nucl Med. 2015 Aug;40(8):621-6.
Title:	Genetic Alterations in Colorectal Cancer Have Different Patterns on 18F-FDG PET/CT.
Author:	Chen, Shang-Wen\|Lin, Chien-Yu\|Ho, Cheng-Man\|Chang, Ya-Sian\|Yang, Shu-Fen\|Kao, Chia-Hung\|Chang, Jan-Gowth
PMID:	26018692

385.
Journal:	Clin Cancer Res. 2015 Sep 15;21(18):4153-64.
Title:	Maintenance Treatment with Cetuximab and BAY86-9766 Increases Antitumor Efficacy of Irinotecan plus Cetuximab in Human Colorectal Cancer Xenograft Models.
Author:	Troiani, Teresa\|Napolitano, Stefania\|Martini, Giulia\|Martinelli, Erika\|Cardone, Claudia\|Normanno, Nicola\|Vitagliano, Donata\|Morgillo, Floriana\|Fenizia, Francesca\|Lambiase, Matilde\|Formisano, Luigi\|Bianco, Roberto\|Ciardiello, Davide\|Ciardiello, Fortunato
PMID:	26019172

386.
Journal:	Int J Med Sci. 2015 Apr 27;12(4):349-53.
Title:	PIK3CA Amplification Is Common in Left Side-Tubular Adenomas but Uncommon Sessile Serrated Adenomas Exclusively with KRAS Mutation.
Author:	Lee, Hyunsu\|Lee, Jae-Ho\|Kim, Dae-Kwang\|Choi, In-Jang\|Hwang, Ilseon\|Kang, Yu-Na\|Kim, Shin
PMID:	26019684

387.
Journal:	Oncotarget. 2015 Oct 6;6(30):28929-37.
Title:	Identification and characterization of RET fusions in advanced colorectal cancer.
Author:	Le Rolle, Anne-France\|Klempner, Samuel J\|Garrett, Christopher R\|Seery, Tara\|Sanford, Eric M\|Balasubramanian, Sohail\|Ross, Jeffrey S\|Stephens, Philip J\|Miller, Vincent A\|Ali, Siraj M\|Chiu, Vi K
PMID:	26078337

388.
Journal:	J Hum Genet. 2015 Oct;60(10):589-96.
Title:	Genetic mutations in human rectal cancers detected by targeted sequencing.
Author:	Bai, Jun\|Gao, Jinglong\|Mao, Zhijun\|Wang, Jianhua\|Li, Jianhui\|Li, Wensheng\|Lei, Yu\|Li, Shuaishuai\|Wu, Zhuo\|Tang, Chuanning\|Jones, Lindsey\|Ye, Hua\|Lou, Feng\|Liu, Zhiyuan\|Dong, Zhishou\|Guo, Baishuai\|Huang, Xue F\|Chen, Si-Yi\|Zhang, Enke
PMID:	26134512

389.
Journal:	Front Pharmacol. 2015 Jun 16;6:120.
Title:	Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models.
Author:	Davis, S Lindsey\|Robertson, Kelli M\|Pitts, Todd M\|Tentler, John J\|Bradshaw-Pierce, Erica L\|Klauck, Peter J\|Bagby, Stacey M\|Hyatt, Stephanie L\|Selby, Heather M\|Spreafico, Anna\|Ecsedy, Jeffrey A\|Arcaroli, John J\|Messersmith, Wells A\|Tan, Aik Choon\|Eckhardt,
PMID:	26136684

390.
Journal:	Dan Med J. 2015 Jul;62(7).
Title:	Computed tomography assessment of early response to neoadjuvant therapy in colon cancer.
Author:	Dam, Claus\|Lund-Rasmussen, Vera\|Ploen, John\|Jakobsen, Anders\|Rafaelsen, Soren Rafael
PMID:	26183044

391.
Journal:	Gastroenterology. 2015 Oct;149(5):1177-1190.e3.
Title:	Genetics and Genetic Biomarkers in Sporadic Colorectal Cancer.
Author:	Carethers, John M\|Jung, Barbara H
PMID:	26216840

392.
Journal:	Mod Pathol. 2015 Oct;28(10):1390-9.
Title:	Performance characteristics of next-generation sequencing in clinical mutation detection of colorectal cancers.
Author:	Haley, Lisa\|Tseng, Li-Hui\|Zheng, Gang\|Dudley, Jonathan\|Anderson, Derek A\|Azad, Nilofer S\|Gocke, Christopher D\|Eshleman, James R\|Lin, Ming-Tseh
PMID:	26226847

393.
Journal:	Cancer Genet. 2015 Sep;208(9):441-7.
Title:	Diagnostic yield of targeted next generation sequencing in various cancer types: an information-theoretic approach.
Author:	Hagemann, Ian S\|O'Neill, Patrick K\|Erill, Ivan\|Pfeifer, John D
PMID:	26227479

394.
Journal:	BMC Cancer. 2015 Aug 1;15:567.
Title:	Durable recurrence-free survival after pneumonectomy for late lung metastasis from rectal cancer: case report with genetic and epigenetic analyses.
Author:	Imperatori, Andrea\|Rotolo, Nicola\|Dominioni, Lorenzo\|Nardecchia, Elisa\|Cattoni, Maria\|Cimetti, Laura\|Riva, Cristina\|Sessa, Fausto\|Furlan, Daniela
PMID:	26231173

395.
Journal:	Cancer Discov. 2015 Aug;5(8):832-41.
Title:	HER2 activating mutations are targets for colorectal cancer treatment.
Author:	Kavuri, Shyam M\|Jain, Naveen\|Galimi, Francesco\|Cottino, Francesca\|Leto, Simonetta M\|Migliardi, Giorgia\|Searleman, Adam C\|Shen, Wei\|Monsey, John\|Trusolino, Livio\|Jacobs, Samuel A\|Bertotti, Andrea\|Bose, Ron
PMID:	26243863

396.
Journal:	Clin Cancer Res. 2015 Dec 15;21(24):5499-5510.
Title:	MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer.
Author:	Garcia-Garcia, Celina\|Rivas, Martin A\|Ibrahim, Yasir H\|Calvo, Maria Teresa\|Gris-Oliver, Albert\|Rodriguez, Olga\|Grueso, Judit\|Anton, Pilar\|Guzman, Marta\|Aura, Claudia\|Nuciforo, Paolo\|Jessen, Katti\|Argiles, Guillem\|Dienstmann, Rodrigo\|Bertotti, Andrea\|Truso
PMID:	26272063

397.
Journal:	Cancer Prev Res (Phila). 2015 Oct;8(10):952-61.
Title:	Colon Tumors with the Simultaneous Induction of Driver Mutations in APC, KRAS, and PIK3CA Still Progress through the Adenoma-to-carcinoma Sequence.
Author:	Hadac, Jamie N\|Leystra, Alyssa A\|Paul Olson, Terrah J\|Maher, Molly E\|Payne, Susan N\|Yueh, Alexander E\|Schwartz, Alexander R\|Albrecht, Dawn M\|Clipson, Linda\|Pasch, Cheri A\|Matkowskyj, Kristina A\|Halberg, Richard B\|Deming, Dustin A
PMID:	26276752

398.
Journal:	Mol Biol (Mosk). 2015 Jul-Aug;49(4):617-27.
Title:	[Biochip detection of KRAS, BRAF, and PIK3CA somatic mutations in colorectal cancer patients].
Author:	Emelyanova, M A\|Amossenko, F A\|Semyanikhina, A V\|Aliev, V A\|Barsukov, Yu A\|Lyubchenko, L N\|Nasedkina, T V
PMID:	26299862

399.
Journal:	Br J Cancer. 2015 Sep 15;113(6):979-88.
Title:	Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer.
Author:	Jorissen, Robert N\|Christie, Michael\|Mouradov, Dmitri\|Sakthianandeswaren, Anuratha\|Li, Shan\|Love, Christopher\|Xu, Zheng-Zhou\|Molloy, Peter L\|Jones, Ian T\|McLaughlin, Stephen\|Ward, Robyn L\|Hawkins, Nicholas J\|Ruszkiewicz, Andrew R\|Moore, James\|Burgess, Ant
PMID:	26305864

400.
Journal:	Br J Cancer. 2015 Sep 15;113(6):914-20.
Title:	KRAS, NRAS, BRAF mutation comparison of endoscopic and surgically removed primary CRC paired samples: is endoscopy biopsy material adequate for molecular evaluation?
Author:	Saridaki, Z\|Saegart, X\|De Vriendt, V\|Hatzidaki, D\|Palmans, S\|De Smedt, L\|De Hertogh, G\|Tejpar, S
PMID:	26325103

401.
Journal:	Ther Adv Med Oncol. 2015 Sep;7(5):252-62.
Title:	Precision medicine in colorectal cancer: the molecular profile alters treatment strategies.
Author:	Tran, Nguyen H\|Cavalcante, Ludmila L\|Lubner, Sam J\|Mulkerin, Daniel L\|LoConte, Noelle K\|Clipson, Linda\|Matkowskyj, Kristina A\|Deming, Dustin A
PMID:	26327923

402.
Journal:	PLoS One. 2015 Sep 16;10(9):e0138141.
Title:	High Prevalence and Clinical Relevance of Genes Affected by Chromosomal Breaks in Colorectal Cancer.
Author:	van den Broek, Evert\|Dijkstra, Maurits J J\|Krijgsman, Oscar\|Sie, Daoud\|Haan, Josien C\|Traets, Joleen J H\|van de Wiel, Mark A\|Nagtegaal, Iris D\|Punt, Cornelis J A\|Carvalho, Beatriz\|Ylstra, Bauke\|Abeln, Sanne\|Meijer, Gerrit A\|Fijneman, Remond J A
PMID:	26375816

403.
Journal:	J Clin Oncol. 2015 Dec 1;33(34):4023-31.
Title:	Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer.
Author:	Corcoran, Ryan B\|Atreya, Chloe E\|Falchook, Gerald S\|Kwak, Eunice L\|Ryan, David P\|Bendell, Johanna C\|Hamid, Omid\|Messersmith, Wells A\|Daud, Adil\|Kurzrock, Razelle\|Pierobon, Mariaelena\|Sun, Peng\|Cunningham, Elizabeth\|Little, Shonda\|Orford, Keith\|Motwani, Mo
PMID:	26392102

404.
Journal:	Int J Mol Sci. 2015 Sep 23;16(9):22976-88.
Title:	Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal Cancers.
Author:	Temraz, Sally\|Mukherji, Deborah\|Shamseddine, Ali
PMID:	26404261

405.
Journal:	Am J Clin Nutr. 2015 Nov;102(5):1134-41.
Title:	Postdiagnostic intake of one-carbon nutrients and alcohol in relation to colorectal cancer survival.
Author:	Lochhead, Paul\|Nishihara, Reiko\|Qian, Zhi Rong\|Mima, Kosuke\|Cao, Yin\|Sukawa, Yasutaka\|Kim, Sun A\|Inamura, Kentaro\|Zhang, Xuehong\|Wu, Kana\|Giovannucci, Edward\|Meyerhardt, Jeffrey A\|Chan, Andrew T\|Fuchs, Charles S\|Ogino, Shuji
PMID:	26423386

406.
Journal:	Oncotarget. 2015 Oct 13;6(31):30592-603.
Title:	Rapid targeted somatic mutation analysis of solid tumors in routine clinical diagnostics.
Author:	Magliacane, Gilda\|Grassini, Greta\|Bartocci, Paola\|Francaviglia, Ilaria\|Dal Cin, Elena\|Barbieri, Gianluca\|Arrigoni, Gianluigi\|Pecciarini, Lorenza\|Doglioni, Claudio\|Cangi, Maria Giulia
PMID:	26435479

407.
Journal:	Oncotarget. 2015 Oct 27;6(33):34561-72.
Title:	Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts.
Author:	Lieu, Christopher H\|Klauck, Peter J\|Henthorn, Patrick K\|Tentler, John J\|Tan, Aik-Choon\|Spreafico, Anna\|Selby, Heather M\|Britt, Blair C\|Bagby, Stacey M\|Arcaroli, John J\|Messersmith, Wells A\|Pitts, Todd M\|Eckhardt, S Gail
PMID:	26439693

408.
Journal:	PLoS One. 2015 Oct 15;10(10):e0140479.
Title:	Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092.
Author:	Yu, Yi\|Savage, Ronald E\|Eathiraj, Sudharshan\|Meade, Justin\|Wick, Michael J\|Hall, Terence\|Abbadessa, Giovanni\|Schwartz, Brian
PMID:	26469692

409.
Journal:	BMC Cancer. 2015 Oct 20;15:747.
Title:	Exploratory biomarker analysis for treatment response in KRAS wild type metastatic colorectal cancer patients who received cetuximab plus irinotecan.
Author:	Kim, Seung Tae\|Ahn, Tae Jin\|Lee, Eunjin\|Do, In-Gu\|Lee, Su Jin\|Park, Se Hoon\|Park, Joon Oh\|Park, Young Suk\|Lim, Ho Yeong\|Kang, Won Ki\|Kim, Suk Hyeong\|Lee, Jeeyun\|Kim, Hee Cheol
PMID:	26486455

410.
Journal:	BMC Cancer. 2015 Oct 24;15:779.
Title:	Clinical detection and categorization of uncommon and concomitant mutations involving BRAF.
Author:	Zheng, Gang\|Tseng, Li-Hui\|Chen, Guoli\|Haley, Lisa\|Illei, Peter\|Gocke, Christopher D\|Eshleman, James R\|Lin, Ming-Tseh
PMID:	26498038

411.
Journal:	Oncotarget. 2015 Dec 1;6(38):40815-21.
Title:	A set of defined oncogenic mutation alleles seems to better predict the response to cetuximab in CRC patient-derived xenograft than KRAS 12/13 mutations.
Author:	Chen, Dawei\|Huang, Xuesong\|Cai, Jie\|Guo, Sheng\|Qian, Wubin\|Wery, Jean-Pierre\|Li, Qi-Xiang
PMID:	26512781

412.
Journal:	Oncotarget. 2015 Dec 8;6(39):42334-44.
Title:	Mutational profiling of colorectal cancers with microsatellite instability.
Author:	Lin, Elaine I\|Tseng, Li-Hui\|Gocke, Christopher D\|Reil, Stacy\|Le, Dung T\|Azad, Nilofer S\|Eshleman, James R
PMID:	26517354

413.
Journal:	Cancer Biol Ther. 2015;16(12):1726-37.
Title:	Molecular profiling of 6,892 colorectal cancer samples suggests different possible treatment options specific to metastatic sites.
Author:	El-Deiry, Wafik S\|Vijayvergia, Namrata\|Xiu, Joanne\|Scicchitano, Angelique\|Lim, Bora\|Yee, Nelson S\|Harvey, Harold A\|Gatalica, Zoran\|Reddy, Sandeep
PMID:	26553611

414.
Journal:	Onco Targets Ther. 2015 Nov 5;8:3265-76.
Title:	Assessing the potential value of long interspersed element-1 hypomethylation in colorectal cancer: evidence from retrospective studies.
Author:	Tang, Jie-Ting\|Wang, Zhen-Hua\|Fang, Jing-Yuan
PMID:	26604793

415.
Journal:	J Dig Cancer Rep. 2015 Jun;3(1):5-10.
Title:	Biomarker-directed Targeted Therapy in Colorectal Cancer.
Author:	Carethers, John M
PMID:	26609516

416.
Journal:	Oncol Lett. 2015 Sep;10(3):1423-1429.
Title:	Mutation of the PIK3CA gene as a prognostic factor in patients with colorectal cancer.
Author:	Stec, Rafal\|Semeniuk-Wojtas, Aleksandra\|Charkiewicz, Radoslaw\|Bodnar, Lubomir\|Korniluk, Jan\|Smoter, Marta\|Chyczewski, Lech\|Niklinski, Jacek\|Szczylik, Cezary
PMID:	26622684

417.
Journal:	PLoS One. 2015 Dec 17;10(12):e0144708.
Title:	Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers.
Author:	Briffa, Romina\|Um, Inhwa\|Faratian, Dana\|Zhou, Ying\|Turnbull, Arran K\|Langdon, Simon P\|Harrison, David J
PMID:	26678268

418.
Journal:	Sci Rep. 2015 Dec 22;5:18678.
Title:	Molecular spectrum of KRAS, NRAS, BRAF and PIK3CA mutations in Chinese colorectal cancer patients: analysis of 1,110 cases.
Author:	Zhang, Jing\|Zheng, Jianming\|Yang, Yinghong\|Lu, Junliang\|Gao, Jie\|Lu, Tao\|Sun, Jian\|Jiang, Hui\|Zhu, Yan\|Zheng, Yuhui\|Liang, Zhiyong\|Liu, Tonghua
PMID:	26691448

419.
Journal:	J Gastrointest Oncol. 2015 Dec;6(6):645-9.
Title:	Impact of somatic mutations on patterns of metastasis in colorectal cancer.
Author:	Lipsyc, Marla\|Yaeger, Rona
PMID:	26697197

420.
Journal:	Int J Clin Exp Pathol. 2015 Oct 1;8(10):13314-22. eCollection 2015.
Title:	Roles of genetic variants in the PI3K/PTEN pathways in susceptibility to colorectal carcinoma and clinical outcomes treated with FOLFOX regimen.
Author:	Lin, Lin\|Zhang, Zhaoxu\|Zhang, Wen\|Wang, Lin\|Wang, Jinwan
PMID:	26722535

421.
Journal:	Cell Death Discov. 2015 Oct 19;1:15044.
Title:	The H1047R point mutation in p110 alpha changes the morphology of human colon HCT116 cancer cells.
Author:	Wan, G\|Pehlke, C\|Pepermans, R\|Cannon, J L\|Lidke, D\|Rajput, A
PMID:	27551473

422.
Journal:	Gut. 2016 Aug;65(8):1296-305.
Title:	Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer.
Author:	Kloth, Michael\|Ruesseler, Vanessa\|Engel, Christoph\|Koenig, Katharina\|Peifer, Martin\|Mariotti, Erika\|Kuenstlinger, Helen\|Florin, Alexandra\|Rommerscheidt-Fuss, Ursula\|Koitzsch, Ulrike\|Wodtke, Claudia\|Ueckeroth, Frank\|Holzapfel, Stefanie\|Aretz, Stefan\|Proppi
PMID:	26001389

423.
Journal:	Clin Cancer Res. 2016 Feb 1;22(3):644-56.
Title:	Tankyrase Inhibition Blocks Wnt/beta-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer.
Author:	Arques, Oriol\|Chicote, Irene\|Puig, Isabel\|Tenbaum, Stephan P\|Argiles, Guillem\|Dienstmann, Rodrigo\|Fernandez, Natalia\|Caratu, Ginevra\|Matito, Judit\|Silberschmidt, Daniel\|Rodon, Jordi\|Landolfi, Stefania\|Prat, Aleix\|Espin, Eloy\|Charco, Ramon\|Nuciforo, Paolo\|
PMID:	26224873

424.
Journal:	J Clin Pathol. 2016 Mar;69(3):204-8.
Title:	Correlation between DPYD gene variation and KRAS wild type status in colorectal cancer.
Author:	Kleist, Britta\|Kempa, Marcel\|Meurer, Thuja\|Poetsch, Micaela
PMID:	26281864

425.
Journal:	Acta Biochim Biophys Sin (Shanghai). 2016 Jan;48(1):27-38.
Title:	RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
Author:	Fang, Bingliang
PMID:	26350096

426.
Journal:	J Clin Pathol. 2016 Jan;69(1):35-41.
Title:	Pre-trial inter-laboratory analytical validation of the FOCUS4 personalised therapy trial.
Author:	Richman, Susan D\|Adams, Richard\|Quirke, Phil\|Butler, Rachel\|Hemmings, Gemma\|Chambers, Phil\|Roberts, Helen\|James, Michelle D\|Wozniak, Sue\|Bathia, Riya\|Pugh, Cheryl\|Maughan, Timothy\|Jasani, Bharat
PMID:	26350752

427.
Journal:	Cancer Immunol Res. 2016 Jan;4(1):33-40.
Title:	MicroRNA MIR21 and T Cells in Colorectal Cancer.
Author:	Mima, Kosuke\|Nishihara, Reiko\|Nowak, Jonathan A\|Kim, Sun A\|Song, Mingyang\|Inamura, Kentaro\|Sukawa, Yasutaka\|Masuda, Atsuhiro\|Yang, Juhong\|Dou, Ruoxu\|Nosho, Katsuhiko\|Baba, Hideo\|Giovannucci, Edward L\|Bowden, Michaela\|Loda, Massimo\|Giannakis, Marios\|Bass,
PMID:	26419959

428.
Journal:	Ann Surg Oncol. 2016 Mar;23(3):849-55.
Title:	Mutation Spectra of Common Cancer-Associated Genes in Different Phenotypes of Colorectal Carcinoma Without Distant Metastasis.
Author:	Chang, Shih-Ching\|Lin, Pei-Ching\|Lin, Jen-Kou\|Lin, Chien-Hsing\|Yang, Shung-Haur\|Liang, Wen-Yi\|Chen, Wei-Shone\|Jiang, Jeng-Kai
PMID:	26471487

429.
Journal:	Clin Cancer Res. 2016 Mar 15;22(6):1489-98.
Title:	Prognostic Utility of Molecular Factors by Age at Diagnosis of Colorectal Cancer.
Author:	McCleary, Nadine J\|Sato, Kaori\|Nishihara, Reiko\|Inamura, Kentaro\|Morikawa, Teppei\|Zhang, Xuehong\|Wu, Kana\|Yamauchi, Mai\|Kim, Sun A\|Sukawa, Yasutaka\|Mima, Kosuke\|Qian, Zhi Rong\|Fuchs, Charles S\|Ogino, Shuji\|Meyerhardt, Jeffrey A
PMID:	26490308

430.
Journal:	Oncotarget. 2016 Jan 12;7(2):1311-22.
Title:	NDRG4 stratifies the prognostic value of body mass index in colorectal cancer.
Author:	Zheng, Jianyong\|Li, Yunming\|Zhu, Shaojun\|Li, Jipeng\|Zhao, Qingchuan\|Ji, Gang\|Wang, Weizhong\|Chu, Dake
PMID:	26515606

431.
Journal:	Arch Pathol Lab Med. 2016 Jun;140(6):529-35.
Title:	Next-Generation Sequencing of Matched Primary and Metastatic Rectal Adenocarcinomas Demonstrates Minimal Mutation Gain and Concordance to Colonic Adenocarcinomas.
Author:	Crumley, Suzanne M\|Pepper, Kristi L\|Phan, Alexandria T\|Olsen, Randall J\|Schwartz, Mary R\|Portier, Bryce P
PMID:	26536055

432.
Journal:	Ann Surg Oncol. 2016 Mar;23(3):908-17.
Title:	Survival Benefit of Exercise Differs by Tumor IRS1 Expression Status in Colorectal Cancer.
Author:	Hanyuda, Akiko\|Kim, Sun A\|Martinez-Fernandez, Alejandro\|Qian, Zhi Rong\|Yamauchi, Mai\|Nishihara, Reiko\|Morikawa, Teppei\|Liao, Xiaoyun\|Inamura, Kentaro\|Mima, Kosuke\|Cao, Yin\|Zhang, Xuehong\|Wu, Kana\|Chan, Andrew T\|Giovannucci, Edward L\|Meyerhardt, Jeffrey A\|
PMID:	26577117

433.
Journal:	J Natl Cancer Inst. 2015 Nov 23;108(4). pii: djv363.
Title:	Prediagnosis Plasma Adiponectin in Relation to Colorectal Cancer Risk According to KRAS Mutation Status.
Author:	Inamura, Kentaro\|Song, Mingyang\|Jung, Seungyoun\|Nishihara, Reiko\|Yamauchi, Mai\|Lochhead, Paul\|Qian, Zhi Rong\|Kim, Sun A\|Mima, Kosuke\|Sukawa, Yasutaka\|Masuda, Atsuhiro\|Imamura, Yu\|Zhang, Xuehong\|Pollak, Michael N\|Mantzoros, Christos S\|Harris, Curtis C\|Giov
PMID:	26598515

434.
Journal:	Genes Chromosomes Cancer. 2016 Mar;55(3):268-77.
Title:	Genetic heterogeneity in synchronous colorectal cancers impacts genotyping approaches and therapeutic strategies.
Author:	Jesinghaus, Moritz\|Pfarr, Nicole\|Kloor, Matthias\|Endris, Volker\|Tavernar, Luca\|Muckenhuber, Alexander\|von Knebel Doeberitz, Magnus\|Penzel, Roland\|Weichert, Wilko\|Stenzinger, Albrecht
PMID:	26650777

435.
Journal:	Clin Oncol (R Coll Radiol). 2016 May;28(5):317-26.
Title:	PIK3CA Mutation, Aspirin Use after Diagnosis and Survival of Colorectal Cancer. A Systematic Review and Meta-analysis of Epidemiological Studies.
Author:	Paleari, L\|Puntoni, M\|Clavarezza, M\|DeCensi, M\|Cuzick, J\|DeCensi, A
PMID:	26712086

436.
Journal:	Cancer Med. 2016 Feb;5(2):248-55.
Title:	Targeting the PI3K signaling pathway in KRAS mutant colon cancer.
Author:	Hong, Suntaek\|Kim, SoYoung\|Kim, Hye Youn\|Kang, Myunghee\|Jang, Ho Hee\|Lee, Won-Suk
PMID:	26715098

437.
Journal:	Cancer Med. 2016 Feb;5(2):256-64.
Title:	KRAS mutation in lung metastases from colorectal cancer: prognostic implications.
Author:	Ghidini, Michele\|Personeni, Nicola\|Bozzarelli, Silvia\|Baretti, Marina\|Basso, Gianluca\|Bianchi, Paolo\|Tronconi, Maria Chiara\|Pressiani, Tiziana\|Grizzi, Fabio\|Giordano, Laura\|Malesci, Alberto\|Alloisio, Marco\|Laghi, Luigi\|Santoro, Armando\|Rimassa, Lorenza
PMID:	26715198

438.
Journal:	Br J Cancer. 2016 Jan 19;114(2):199-206.
Title:	Loss of CDH1 (E-cadherin) expression is associated with infiltrative tumour growth and lymph node metastasis.
Author:	Kim, Sun A\|Inamura, Kentaro\|Yamauchi, Mai\|Nishihara, Reiko\|Mima, Kosuke\|Sukawa, Yasutaka\|Li, Tingting\|Yasunari, Mika\|Morikawa, Teppei\|Fitzgerald, Kathryn C\|Fuchs, Charles S\|Wu, Kana\|Chan, Andrew T\|Zhang, Xuehong\|Ogino, Shuji\|Qian, Zhi Rong
PMID:	26742007

439.
Journal:	Tumour Biol. 2016 Jul;37(7):8799-809.
Title:	PIK3CA and PIK3CB silencing by RNAi reverse MDR and inhibit tumorigenic properties in human colorectal carcinoma.
Author:	Wu, Shuhua\|Wen, Feifei\|Li, Yangyang\|Gao, Xiangqian\|He, Shuang\|Liu, Mengyao\|Zhang, Xiangzhi\|Tian, Dong
PMID:	26747178

440.
Journal:	Oncotarget. 2016 Feb 23;7(8):9188-221.
Title:	BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells.
Author:	Goulielmaki, Maria\|Koustas, Evangelos\|Moysidou, Eirini\|Vlassi, Margarita\|Sasazuki, Takehiko\|Shirasawa, Senji\|Zografos, George\|Oikonomou, Eftychia\|Pintzas, Alexander
PMID:	26802026

441.
Journal:	Eur J Cancer. 2016 Mar;56:69-76.
Title:	Pre-clinical use of isogenic cell lines and tumours in vitro and in vivo for predictive biomarker discovery; impact of KRAS and PI3KCA mutation status on MEK inhibitor activity is model dependent.
Author:	Haagensen, Emma J\|Thomas, Huw D\|Mudd, Clare\|Tsonou, Elpida\|Wiggins, Ceri M\|Maxwell, Ross J\|Moore, Jonathan D\|Newell, David R
PMID:	26820797

442.
Journal:	BMC Syst Biol. 2016 Feb 11;10:16.
Title:	Integrative modeling of multi-omics data to identify cancer drivers and infer patient-specific gene activity.
Author:	Pavel, Ana B\|Sonkin, Dmitriy\|Reddy, Anupama
PMID:	26864072

443.
Journal:	Onco Targets Ther. 2016 Jan 27;9:557-65.
Title:	Biomarkers predicting resistance to epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer with wild-type KRAS.
Author:	Liu, Jiang\|Hu, Jing\|Cheng, Lei\|Ren, Wei\|Yang, Mi\|Liu, Baorui\|Xie, Li\|Qian, Xiaoping
PMID:	26869800

444.
Journal:	Oncotarget. 2016 Apr 12;7(15):19610-9.
Title:	Molecular characterization of colorectal cancer patients and concomitant patient-derived tumor cell establishment.
Author:	Song, Haa-Na\|Lee, Chung\|Kim, Seung Tae\|Kim, Sun Young\|Kim, Nayoung K D\|Jang, Jiryeon\|Kang, Mihyun\|Jang, Hyojin\|Ahn, Soomin\|Kim, Seok Hyeong\|Park, Yoona\|Cho, Yong Beom\|Heo, Jeong Wook\|Lee, Woo Yong\|Park, Joon Oh\|Lim, Ho Yeong\|Kang, Won Ki\|Park, Young Suk\|P
PMID:	26909603

445.
Journal:	Breast Cancer Res Treat. 2016 Feb;156(1):33-43.
Title:	Mutations in PIK3CA sensitize breast cancer cells to physiologic levels of aspirin.
Author:	Turturro, Sanja B\|Najor, Matthew S\|Ruby, Carl E\|Cobleigh, Melody A\|Abukhdeir, Abde M
PMID:	26915040

446.
Journal:	Genes Chromosomes Cancer. 2016 Jun;55(6):505-21.
Title:	Genotyping of colorectal cancer for cancer precision medicine: Results from the IPH Center for Molecular Pathology.
Author:	Jesinghaus, Moritz\|Pfarr, Nicole\|Endris, Volker\|Kloor, Matthias\|Volckmar, Anna-Lena\|Brandt, Regine\|Herpel, Esther\|Muckenhuber, Alexander\|Lasitschka, Felix\|Schirmacher, Peter\|Penzel, Roland\|Weichert, Wilko\|Stenzinger, Albrecht
PMID:	26917275

447.
Journal:	Asian Pac J Cancer Prev. 2016;17(2):539-43.
Title:	Value of KRAS, BRAF, and PIK3CA Mutations and Survival Benefit from Systemic Chemotherapy in Colorectal Peritoneal Carcinomatosis.
Author:	Sasaki, Yusuke\|Hamaguchi, Tetsuya\|Yamada, Yasuhide\|Takahashi, Naoki\|Shoji, Hirokazu\|Honma, Yoshitaka\|Iwasa, Satoru\|Okita, Natsuko\|Takashima, Atsuo\|Kato, Ken\|Nagai, Yushi\|Taniguchi, Hirokazu\|Boku, Narikazu\|Ushijima, Toshikazu\|Shimada, Yasuhiro
PMID:	26925640

448.
Journal:	Clin Cancer Res. 2016 Aug 1;22(15):3841-8.
Title:	MicroRNA MIR21 (miR-21) and PTGS2 Expression in Colorectal Cancer and Patient Survival.
Author:	Mima, Kosuke\|Nishihara, Reiko\|Yang, Juhong\|Dou, Ruoxu\|Masugi, Yohei\|Shi, Yan\|da Silva, Annacarolina\|Cao, Yin\|Song, Mingyang\|Nowak, Jonathan\|Gu, Mancang\|Li, Wanwan\|Morikawa, Teppei\|Zhang, Xuehong\|Wu, Kana\|Baba, Hideo\|Giovannucci, Edward L\|Meyerhardt, Jeffr
PMID:	26957558

449.
Journal:	Oncotarget. 2016 Apr 19;7(16):22543-55.
Title:	Determination of somatic oncogenic mutations linked to target-based therapies using MassARRAY technology.
Author:	Ibarrola-Villava, Maider\|Fleitas, Tania\|Llorca-Cardenosa, Marta J\|Mongort, Cristina\|Alonso, Elisa\|Navarro, Samuel\|Burgues, Octavio\|Vivancos, Ana\|Cejalvo, Juan Miguel\|Perez-Fidalgo, Jose Alejandro\|Rosello, Susana\|Ribas, Gloria\|Cervantes, Andres
PMID:	26968814

450.
Journal:	Mol Cancer Ther. 2016 Jun;15(6):1217-26.
Title:	Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.
Author:	Togel, Lars\|Nightingale, Rebecca\|Chueh, Anderly C\|Jayachandran, Aparna\|Tran, Hoanh\|Phesse, Toby\|Wu, Rui\|Sieber, Oliver M\|Arango, Diego\|Dhillon, Amardeep S\|Dawson, Mark A\|Diez-Dacal, Beatriz\|Gahman, Timothy C\|Filippakopoulos, Panagis\|Shiau, Andrew K\|Mariad
PMID:	26983878

451.
Journal:	PLoS One. 2016 Mar 18;11(3):e0151865.
Title:	BRAF, PIK3CA, and HER2 Oncogenic Alterations According to KRAS Mutation Status in Advanced Colorectal Cancers with Distant Metastasis.
Author:	Nam, Soo Kyung\|Yun, Sumi\|Koh, Jiwon\|Kwak, Yoonjin\|Seo, An Na\|Park, Kyoung Un\|Kim, Duck-Woo\|Kang, Sung-Bum\|Kim, Woo Ho\|Lee, Hye Seung
PMID:	26991109

452.
Journal:	Int J Cancer. 2016 Aug 1;139(3):647-56.
Title:	Impact of KRAS, BRAF, PIK3CA, TP53 status and intraindividual mutation heterogeneity on outcome after liver resection for colorectal cancer metastases.
Author:	Loes, Inger Marie\|Immervoll, Heike\|Sorbye, Halfdan\|Angelsen, Jon-Helge\|Horn, Arild\|Knappskog, Stian\|Lonning, Per Eystein
PMID:	26991344

453.
Journal:	Ann Oncol. 2016 Jun;27(6):1055-61.
Title:	Cetuximab continuation after first progression in metastatic colorectal cancer (CAPRI-GOIM): a randomized phase II trial of FOLFOX plus cetuximab versus FOLFOX.
Author:	Ciardiello, F\|Normanno, N\|Martinelli, E\|Troiani, T\|Pisconti, S\|Cardone, C\|Nappi, A\|Bordonaro, A R\|Rachiglio, M\|Lambiase, M\|Latiano, T P\|Modoni, G\|Cordio, S\|Giuliani, F\|Biglietto, M\|Montesarchio, V\|Barone, C\|Tonini, G\|Cinieri, S\|Febbraro, A\|Rizzi, D\|De Vit
PMID:	27002107

454.
Journal:	Int J Cancer. 2016 Aug 15;139(4):803-11.
Title:	RAS mutation is a prognostic biomarker in colorectal cancer patients with metastasectomy.
Author:	Osumi, Hiroki\|Shinozaki, Eiji\|Suenaga, Mitsukuni\|Matsusaka, Satoshi\|Konishi, Tsuyoshi\|Akiyoshi, Takashi\|Fujimoto, Yoshiya\|Nagayama, Satoshi\|Fukunaga, Yosuke\|Ueno, Masashi\|Mise, Yoshihiro\|Ishizawa, Takeaki\|Inoue, Yosuke\|Takahashi, Yu\|Saiura, Akio\|Uehara, H
PMID:	27004837

455.
Journal:	Pathol Oncol Res. 2016 Oct;22(4):707-14.
Title:	The Prognostic Influence of BRAF Mutation and other Molecular, Clinical and Laboratory Parameters in Stage IV Colorectal Cancer.
Author:	Karadima, Maria L\|Saetta, Angelica A\|Chatziandreou, Ilenia\|Lazaris, Andreas C\|Patsouris, Efstratios\|Tsavaris, Nikolaos
PMID:	27033063

456.
Journal:	Curr Colorectal Cancer Rep. 2016;12:27-34.
Title:	Aspirin and Colorectal Cancer Prevention and Treatment: Is It for Everyone?
Author:	Coyle, Christopher\|Cafferty, Fay Helen\|Langley, Ruth Elizabeth
PMID:	27069437

457.
Journal:	Sci Rep. 2016 Apr 14;6:24310.
Title:	Prognostic impact of mutation profiling in patients with stage II and III colon cancer.
Author:	Shen, Yinchen\|Han, Xiaohong\|Wang, Jianfei\|Wang, Shuai\|Yang, Hongying\|Lu, Shih-Hsin\|Shi, Yuankai
PMID:	27074743

458.
Journal:	Sci Rep. 2016 Apr 20;6:24720.
Title:	miRs-134 and -370 function as tumor suppressors in colorectal cancer by independently suppressing EGFR and PI3K signalling.
Author:	El-Daly, Sherien M\|Abba, Mohammed L\|Patil, Nitin\|Allgayer, Heike
PMID:	27095166

459.
Journal:	PLoS One. 2016 Apr 20;11(4):e0152402.
Title:	Aspirin in the Treatment of Cancer: Reductions in Metastatic Spread and in Mortality: A Systematic Review and Meta-Analyses of Published Studies.
Author:	Elwood, Peter C\|Morgan, Gareth\|Pickering, Janet E\|Galante, Julieta\|Weightman, Alison L\|Morris, Delyth\|Kelson, Mark\|Dolwani, Sunil
PMID:	27096951

460.
Journal:	Clin Colorectal Cancer. 2016 Dec;15(4):337-344.e2.
Title:	A Randomized, Phase II Trial of Cetuximab With or Without PX-866, an Irreversible Oral Phosphatidylinositol 3-Kinase Inhibitor, in Patients With Metastatic Colorectal Carcinoma.
Author:	Bowles, Daniel W\|Kochenderfer, Mark\|Cohn, Allen\|Sideris, Lucas\|Nguyen, Nghia\|Cline-Burkhardt, Vivian\|Schnadig, Ian\|Choi, Minsig\|Nabell, Lisle\|Chaudhry, Arvind\|Ruxer, Robert\|Ucar, Antonio\|Hausman, Diana\|Walker, Luke\|Spira, Alexander\|Jimeno, Antonio
PMID:	27118441

461.
Journal:	J Transl Med. 2016 May 4;14(1):118.
Title:	Clinical significance of frequent somatic mutations detected by high-throughput targeted sequencing in archived colorectal cancer samples.
Author:	Dallol, Ashraf\|Buhmeida, Abdelbaset\|Al-Ahwal, Mahmoud Shaheen\|Al-Maghrabi, Jaudah\|Bajouh, Osama\|Al-Khayyat, Shadi\|Alam, Rania\|Abusanad, Atlal\|Turki, Rola\|Elaimi, Aisha\|Alhadrami, Hani A\|Abuzenadah, Mohammed\|Banni, Huda\|Al-Qahtani, Mohammed H\|Abuzenadah, A
PMID:	27146902

462.
Journal:	Int J Oncol. 2016 Jul;49(1):276-84.
Title:	Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma.
Author:	Harada, Koji\|Ferdous, Tarannum\|Harada, Toyoko\|Ueyama, Yoshiya
PMID:	27210058

463.
Journal:	Front Physiol. 2016 May 9;7:168.
Title:	The Inositide Signaling Pathway As a Target for Treating Gastric Cancer and Colorectal Cancer.
Author:	Kim, Hong Jun\|Lee, Suk-Young\|Oh, Sang Cheul
PMID:	27242542

464.
Journal:	BMC Cancer. 2016 May 31;16:339.
Title:	ICECREAM: randomised phase II study of cetuximab alone or in combination with irinotecan in patients with metastatic colorectal cancer with either KRAS, NRAS, BRAF and PI3KCA wild type, or G13D mutated tumours.
Author:	Segelov, Eva\|Waring, Paul\|Desai, Jayesh\|Wilson, Kate\|Gebski, Val\|Thavaneswaran, Subotheni\|Elez, Elena\|Underhill, Craig\|Pavlakis, Nick\|Chantrill, Lorraine\|Nott, Louise\|Jefford, Michael\|Khasraw, Mustafa\|Day, Fiona\|Wasan, Harpreet\|Ciardiello, Fortunato\|Karap
PMID:	27246726

465.
Journal:	Oncotarget. 2016 Aug 9;7(32):50875-50882.
Title:	Recurrent, truncating SOX9 mutations are associated with SOX9 overexpression, KRAS mutation, and TP53 wild type status in colorectal carcinoma.
Author:	Javier, Breanna M\|Yaeger, Rona\|Wang, Lu\|Sanchez-Vega, Francisco\|Zehir, Ahmet\|Middha, Sumit\|Sadowska, Justyna\|Vakiani, Efsevia\|Shia, Jinru\|Klimstra, David\|Ladanyi, Marc\|Iacobuzio-Donahue, Christine A\|Hechtman, Jaclyn F
PMID:	27248473

466.
Journal:	Med Oncol. 2016 Jul;33(7):71.
Title:	Comparison of KRAS mutation status between primary tumor and metastasis in Chinese colorectal cancer patients.
Author:	Li, Zhe-Zhen\|Bai, Long\|Wang, Feng\|Zhang, Zi-Chen\|Wang, Fang\|Zeng, Zhao-Lei\|Zeng, Jun-Bo\|Zhang, Dong-Sheng\|Wang, Feng-Hua\|Wang, Zhi-Qiang\|Li, Yu-Hong\|Shao, Jian-Yong\|Xu, Rui-Hua
PMID:	27270901

467.
Journal:	Oncotarget. 2016 Jun 28;7(26):39293-39301.
Title:	Mutations of KRAS, NRAS, BRAF, EGFR, and PIK3CA genes in urachal carcinoma: Occurence and prognostic significance.
Author:	Modos, Orsolya\|Reis, Henning\|Niedworok, Christian\|Rubben, Herbert\|Szendroi, Attila\|Szasz, Marcell A\|Timar, Jozsef\|Baghy, Kornelia\|Kovalszky, Ilona\|Golabek, Tomasz\|Chlosta, Piotr\|Okon, Krzysztof\|Peyronnet, Benoit\|Mathieu, Romain\|Shariat, Shahrokh F\|Hollosi
PMID:	27283768

468.
Journal:	Crit Rev Oncol Hematol. 2016 Aug;104:87-90.
Title:	The role of aspirin in colorectal cancer chemoprevention.
Author:	Singh Ranger, Gurpreet
PMID:	27289249

469.
Journal:	Gastroenterology. 2016 Sep;151(3):440-447.e1.
Title:	Frequent PIK3CA Mutations in Colorectal and Endometrial Tumors With 2 or More Somatic Mutations in Mismatch Repair Genes.
Author:	Cohen, Stacey A\|Turner, Emily H\|Beightol, Mallory B\|Jacobson, Angela\|Gooley, Ted A\|Salipante, Stephen J\|Haraldsdottir, Sigurdis\|Smith, Christina\|Scroggins, Sheena\|Tait, Jonathan F\|Grady, William M\|Lin, Edward H\|Cohn, David E\|Goodfellow, Paul J\|Arnold, Mar
PMID:	27302833

470.
Journal:	Nat Commun. 2016 Jun 20;7:11971.
Title:	Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.
Author:	Hao, Yujun\|Samuels, Yardena\|Li, Qingling\|Krokowski, Dawid\|Guan, Bo-Jhih\|Wang, Chao\|Jin, Zhicheng\|Dong, Bohan\|Cao, Bo\|Feng, Xiujing\|Xiang, Min\|Xu, Claire\|Fink, Stephen\|Meropol, Neal J\|Xu, Yan\|Conlon, Ronald A\|Markowitz, Sanford\|Kinzler, Kenneth W\|Velculesc
PMID:	27321283

471.
Journal:	Virchows Arch. 2016 Aug;469(2):125-34.
Title:	Molecular pathological classification of colorectal cancer.
Author:	Muller, Mike F\|Ibrahim, Ashraf E K\|Arends, Mark J
PMID:	27325016

472.
Journal:	Dig Dis. 2016;34(5):574-9.
Title:	Therapeutic Strategies in Diseases of the Digestive Tract - 2015 and Beyond Targeted Therapies in Colon Cancer Today and Tomorrow.
Author:	Pohl, Michael\|Schmiegel, Wolff
PMID:	27332557

473.
Journal:	Bull Cancer. 2016 Jul-Aug;103(7-8):643-50.
Title:	[New molecular classification of colorectal cancer, pancreatic cancer and stomach cancer: Towards "a la carte" treatment?].
Author:	Dreyer, Chantal\|Afchain, Pauline\|Trouilloud, Isabelle\|Andre, Thierry
PMID:	27345450

474.
Journal:	Oncotarget. 2016 Aug 23;7(34):55098-55109.
Title:	Tumor LINE-1 methylation level and colorectal cancer location in relation to patient survival.
Author:	Mima, Kosuke\|Nowak, Jonathan A\|Qian, Zhi Rong\|Cao, Yin\|Song, Mingyang\|Masugi, Yohei\|Shi, Yan\|da Silva, Annacarolina\|Gu, Mancang\|Li, Wanwan\|Hamada, Tsuyoshi\|Zhang, Xuehong\|Wu, Kana\|Meyerhardt, Jeffrey A\|Baba, Hideo\|Giovannucci, Edward L\|Chan, Andrew T\|Fuch
PMID:	27391152

475.
Journal:	Virchows Arch. 2016 Oct;469(4):459-64.
Title:	Challenging a dogma: co-mutations exist in MAPK pathway genes in colorectal cancer.
Author:	Grellety, Thomas\|Gros, Audrey\|Pedeutour, Florence\|Merlio, Jean-Philippe\|Duranton-Tanneur, Valerie\|Italiano, Antoine\|Soubeyran, Isabelle
PMID:	27401719

476.
Journal:	BMC Cancer. 2016 Jul 12;16:454.
Title:	Highly sensitive detection of the PIK3CA (H1047R) mutation in colorectal cancer using a novel PCR-RFLP method.
Author:	Li, Wan-Ming\|Hu, Ting-Ting\|Zhou, Lin-Lin\|Feng, Yi-Ming\|Wang, Yun-Yi\|Fang, Jin
PMID:	27405731

477.
Journal:	Int J Clin Oncol. 2016 Dec;21(6):1091-1101.
Title:	CpG island methylator phenotype is associated with the efficacy of sequential oxaliplatin- and irinotecan-based chemotherapy and EGFR-related gene mutation in Japanese patients with metastatic colorectal cancer.
Author:	Zhang, Xiaofei\|Shimodaira, Hideki\|Soeda, Hiroshi\|Komine, Keigo\|Takahashi, Hidekazu\|Ouchi, Kota\|Inoue, Masahiro\|Takahashi, Masanobu\|Takahashi, Shin\|Ishioka, Chikashi
PMID:	27435270

478.
Journal:	Ann Oncol. 2016 Oct;27(10):1836-48.
Title:	Prognostic role of tumor PIK3CA mutation in colorectal cancer: a systematic review and meta-analysis.
Author:	Mei, Z B\|Duan, C Y\|Li, C B\|Cui, L\|Ogino, S
PMID:	27436848

479.
Journal:	BMC Cancer. 2016 Jul 26;16:531.
Title:	Pro-survival responses to the dual inhibition of anti-apoptotic Bcl-2 family proteins and mTOR-mediated signaling in hypoxic colorectal carcinoma cells.
Author:	Risberg, Karianne\|Redalen, Kathrine Roe\|Sonstevold, Linda\|Bjornetro, Tonje\|Solvernes, Janne\|Ree, Anne Hansen
PMID:	27461218

480.
Journal:	J Pathol Clin Res. 2016 Apr 15;2(3):166-74.
Title:	Somatic mutation profiles in primary colorectal cancers and matching ovarian metastases: Identification of driver and passenger mutations.
Author:	Crobach, Stijn\|Ruano, Dina\|van Eijk, Ronald\|Schrumpf, Melanie\|Fleuren, Gertjan\|van Wezel, Tom\|Morreau, Hans
PMID:	27499925

481.
Journal:	Int J Cancer. 2016 Dec 1;139(11):2493-501.
Title:	Molecular differences in the microsatellite stable phenotype between left-sided and right-sided colorectal cancer.
Author:	Takahashi, Yayoi\|Sugai, Tamotsu\|Habano, Wataru\|Ishida, Kazuyuki\|Eizuka, Makoto\|Otsuka, Koki\|Sasaki, Akira\|Takayuki Matsumoto\|Morikawa, Takanori\|Unno, Michiaki\|Suzuki, Hiromu
PMID:	27509333

482.
Journal:	Tumour Biol. 2016 Oct;37(10):14089-14101.
Title:	Experimental verification of a predicted novel microRNA located in human PIK3CA gene with a potential oncogenic function in colorectal cancer.
Author:	Saleh, Ali Jason\|Soltani, Bahram M\|Dokanehiifard, Sadat\|Medlej, Abdallah\|Tavalaei, Mahmoud\|Mowla, Seyed Javad
PMID:	27511117

483.
Journal:	World J Gastroenterol. 2016 Aug 14;22(30):6944-54.
Title:	Prognostic and predictive biomarkers in metastatic colorectal cancer anti-EGFR therapy.
Author:	Lo Nigro, Cristiana\|Ricci, Vincenzo\|Vivenza, Daniela\|Granetto, Cristina\|Fabozzi, Teresa\|Miraglio, Emanuela\|Merlano, Marco C
PMID:	27570430

484.
Journal:	Oncotarget. 2016 Oct 18;7(42):68546-68558.
Title:	Specific inhibition of p110alpha subunit of PI3K: putative therapeutic strategy for KRAS mutant colorectal cancers.
Author:	Fernandes, Maria Sofia\|Melo, Soraia\|Velho, Sergia\|Carneiro, Patricia\|Carneiro, Fatima\|Seruca, Raquel
PMID:	27602501

485.
Journal:	Clin Med Insights Pathol. 2016 Sep 7;9:19-28.
Title:	Oncogene Mutations in Colorectal Polyps Identified in the Norwegian Colorectal Cancer Prevention (NORCCAP) Screening Study.
Author:	Lorentzen, Jon A\|Grzyb, Krzysztof\|De Angelis, Paula M\|Hoff, Geir\|Eide, Tor J\|Andresen, Per Arne
PMID:	27656095

486.
Journal:	Oncotarget. 2016 Nov 8;7(45):72908-72922.
Title:	Genomic characterization of liver metastases from colorectal cancer patients.
Author:	Sayagues, Jose Maria\|Corchete, Luis Antonio\|Gutierrez, Maria Laura\|Sarasquete, Maria Eugenia\|Del Mar Abad, Maria\|Bengoechea, Oscar\|Ferminan, Encarna\|Anduaga, Maria Fernanda\|Del Carmen, Sofia\|Iglesias, Manuel\|Esteban, Carmen\|Angoso, Maria\|Alcazar, Jose Ant
PMID:	27662660

487.
Journal:	Oncologist. 2016 Nov;21(11):1306-1314.
Title:	Broad Detection of Alterations Predicted to Confer Lack of Benefit From EGFR Antibodies or Sensitivity to Targeted Therapy in Advanced Colorectal Cancer.
Author:	Rankin, Andrew\|Klempner, Samuel J\|Erlich, Rachel\|Sun, James X\|Grothey, Axel\|Fakih, Marwan\|George, Thomas J Jr\|Lee, Jeeyun\|Ross, Jeffrey S\|Stephens, Philip J\|Miller, Vincent A\|Ali, Siraj M\|Schrock, Alexa B
PMID:	27682134

488.
Journal:	Oncotarget. 2016 Nov 8;7(45):73876-73887.
Title:	Genomic profiling of stage II and III colon cancers reveals APC mutations to be associated with survival in stage III colon cancer patients.
Author:	van den Broek, Evert\|Krijgsman, Oscar\|Sie, Daoud\|Tijssen, Marianne\|Mongera, Sandra\|van de Wiel, Mark A\|Belt, Eric J Th\|den Uil, Sjoerd H\|Bril, Herman\|Stockmann, Hein B A C\|Ylstra, Bauke\|Carvalho, Beatriz\|Meijer, Gerrit A\|Fijneman, Remond J A
PMID:	27729614

489.
Journal:	J Transl Med. 2016 Oct 13;14(1):292.
Title:	Prognostic impact of KRAS, NRAS, BRAF, and PIK3CA mutations in primary colorectal carcinomas: a population-based study.
Author:	Palomba, Grazia\|Doneddu, Valentina\|Cossu, Antonio\|Paliogiannis, Panagiotis\|Manca, Antonella\|Casula, Milena\|Colombino, Maria\|Lanzillo, Annamaria\|Defraia, Efisio\|Pazzola, Antonio\|Sanna, Giovanni\|Putzu, Carlo\|Ortu, Salvatore\|Scartozzi, Mario\|Ionta, Maria Ter
PMID:	27737711

490.
Journal:	Cancer Immunol Res. 2016 Nov;4(11):927-935.
Title:	MicroRNA let-7, T Cells, and Patient Survival in Colorectal Cancer.
Author:	Dou, Ruoxu\|Nishihara, Reiko\|Cao, Yin\|Hamada, Tsuyoshi\|Mima, Kosuke\|Masuda, Atsuhiro\|Masugi, Yohei\|Shi, Yan\|Gu, Mancang\|Li, Wanwan\|da Silva, Annacarolina\|Nosho, Katsuhiko\|Zhang, Xuehong\|Meyerhardt, Jeffrey A\|Giovannucci, Edward L\|Chan, Andrew T\|Fuchs, Char
PMID:	27737877

491.
Journal:	Mol Cancer. 2016 Oct 18;15(1):63.
Title:	Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing.
Author:	Kovaleva, Valentina\|Geissler, Anna-Lena\|Lutz, Lisa\|Fritsch, Ralph\|Makowiec, Frank\|Wiesemann, Sebastian\|Hopt, Ulrich T\|Passlick, Bernward\|Werner, Martin\|Lassmann, Silke
PMID:	27756406

492.
Journal:	World J Clin Oncol. 2016 Oct 10;7(5):340-351.
Title:	Oncogenic fingerprint of epidermal growth factor receptor pathway and emerging epidermal growth factor receptor blockade resistance in colorectal cancer.
Author:	Sobani, Zain A\|Sawant, Ashwin\|Jafri, Mikram\|Correa, Amit Keith\|Sahin, Ibrahim Halil
PMID:	27777877

493.
Journal:	Oncotarget. 2016 Dec 20;7(51):85124-85141.
Title:	Combination of COX-2 expression and PIK3CA mutation as prognostic and predictive markers for celecoxib treatment in breast cancer.
Author:	Tury, Sandrine\|Becette, Veronique\|Assayag, Franck\|Vacher, Sophie\|Benoist, Camille\|Kamal, Maud\|Marangoni, Elisabetta\|Bieche, Ivan\|Lerebours, Florence\|Callens, Celine
PMID:	27835884

494.
Journal:	Oncotarget. 2016 Dec 20;7(51):85349-85364.
Title:	Enumeration and targeted analysis of KRAS, BRAF and PIK3CA mutations in CTCs captured by a label-free platform: Comparison to ctDNA and tissue in metastatic colorectal cancer.
Author:	Kidess-Sigal, Evelyn\|Liu, Haiyan E\|Triboulet, Melanie M\|Che, James\|Ramani, Vishnu C\|Visser, Brendan C\|Poultsides, George A\|Longacre, Teri A\|Marziali, Andre\|Vysotskaia, Valentina\|Wiggin, Matthew\|Heirich, Kyra\|Hanft, Violet\|Keilholz, Ulrich\|Tinhofer, Ingebo
PMID:	27863403

495.
Journal:	Mol Clin Oncol. 2016 Nov;5(5):579-582.
Title:	Favorable control of advanced colon adenocarcinoma with severe bone marrow metastasis: A case report.
Author:	Hanamura, Fumiyasu\|Shibata, Yoshihiro\|Shirakawa, Tsuyoshi\|Kuwayama, Miyuki\|Oda, Hisanobu\|Ariyama, Hiroshi\|Taguchi, Kenichi\|Esaki, Taito\|Baba, Eishi
PMID:	27900088

496.
Journal:	J Gastrointest Oncol. 2016 Dec;7(6):882-902.
Title:	Molecular spectrum of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC somatic gene mutations in Arab patients with colorectal cancer: determination of frequency and distribution pattern.
Author:	Al-Shamsi, Humaid O\|Jones, Jeremy\|Fahmawi, Yazan\|Dahbour, Ibrahim\|Tabash, Aziz\|Abdel-Wahab, Reham\|Abousamra, Ahmed O S\|Shaw, Kenna R\|Xiao, Lianchun\|Hassan, Manal M\|Kipp, Benjamin R\|Kopetz, Scott\|Soliman, Amr S\|McWilliams, Robert R\|Wolff, Robert A
PMID:	28078112

497.
Journal:	Genes Dev. 2016 Dec 15;30(24):2684-2695.
Title:	Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover.
Author:	Davoli, Teresa\|Mengwasser, Kristen E\|Duan, Jingjing\|Chen, Ting\|Christensen, Camilla\|Wooten, Eric C\|Anselmo, Anthony N\|Li, Mamie Z\|Wong, Kwok-Kin\|Kahle, Kristopher T\|Elledge, Stephen J
PMID:	28087713

498.
Journal:	Gan To Kagaku Ryoho. 2016 Nov;43(12):1800-1802.
Title:	[A Case of Metastatic Colon Cancer Dramatically Affected by Anti-EGFR Antibody Therapy].
Author:	Yagi, Ryoma\|Shimada, Yoshifumi\|Miura, Kohei\|Tajima, Yosuke\|Okamura, Takuma\|Nakano, Masato\|Ichikawa, Hiroshi\|Nagahashi, Masayuki\|Sakata, Jun\|Kobayashi, Takashi\|Kameyama, Hitoshi\|Wakai, Toshifumi\|Nogami, Hitoshi\|Maruyama, Satoshi\|Takii, Yasumasa
PMID:	28133136

499.
Journal:	Acta Med Litu. 2016;23(1):24-34.
Title:	Significance of KRAS, NRAS, BRAF and PIK3CA mutations in metastatic colorectal cancer patients receiving Bevacizumab: a single institution experience.
Author:	Baltruskeviciene, Edita\|Mickys, Ugnius\|Zvirblis, Tadas\|Stulpinas, Rokas\|Pipiriene Zelviene, Terese\|Aleknavicius, Eduardas
PMID:	28356789

500.
Journal:	ESMO Open. 2017 Feb 20;1(6):e000086.
Title:	Clinical activity and tolerability of FOLFIRI and cetuximab in elderly patients with metastatic colorectal cancer in the CAPRI-GOIM first-line trial.
Author:	Martinelli, E\|Cardone, C\|Troiani, T\|Normanno, N\|Pisconti, S\|Sforza, V\|Bordonaro, A R\|Rachiglio, A M\|Lambiase, M\|Latiano, T P\|Modoni, G\|Cordio, S\|Giuliani, F\|Biglietto, M\|Montesarchio, V\|Barone, C\|Tonini, G\|Cinieri, S\|Febbraro, A\|Rizzi, D\|De Vita, F\|Orditu
PMID:	28848656

501.
Journal:	Mol Oncol. 2016 Dec;10(10):1575-1584.
Title:	Somatic mutation detection using various targeted detection assays in paired samples of circulating tumor DNA, primary tumor and metastases from patients undergoing resection of colorectal liver metastases.
Author:	Beije, Nick\|Helmijr, Jean C\|Weerts, Marjolein J A\|Beaufort, Corine M\|Wiggin, Matthew\|Marziali, Andre\|Verhoef, Cornelis\|Sleijfer, Stefan\|Jansen, Maurice P H M\|Martens, John W M
PMID:	28949453

502.
Journal:	Gut. 2017 Aug;66(8):1463-1473.
Title:	Tumour CD274 (PD-L1) expression and T cells in colorectal cancer.
Author:	Masugi, Yohei\|Nishihara, Reiko\|Yang, Juhong\|Mima, Kosuke\|da Silva, Annacarolina\|Shi, Yan\|Inamura, Kentaro\|Cao, Yin\|Song, Mingyang\|Nowak, Jonathan A\|Liao, Xiaoyun\|Nosho, Katsuhiko\|Chan, Andrew T\|Giannakis, Marios\|Bass, Adam J\|Hodi, F Stephen\|Freeman, Gordo
PMID:	27196573

503.
Journal:	Cancer Res Treat. 2017 Jan;49(1):161-167.
Title:	Paired Primary and Metastatic Tumor Analysis of Somatic Mutations in Synchronous and Metachronous Colorectal Cancer.
Author:	Kim, Kyu-Pyo\|Kim, Jeong-Eun\|Hong, Yong Sang\|Ahn, Sung-Min\|Chun, Sung Min\|Hong, Seung-Mo\|Jang, Se Jin\|Yu, Chang Sik\|Kim, Jin Cheon\|Kim, Tae Won
PMID:	27384156

504.
Journal:	Oncogene. 2017 Feb 9;36(6):787-796.
Title:	FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.
Author:	Tong, J\|Tan, S\|Zou, F\|Yu, J\|Zhang, L
PMID:	27399335

505.
Journal:	Semin Cell Dev Biol. 2017 Apr;64:107-115.
Title:	Colorectal cancer heterogeneity and targeted therapy: Clinical implications, challenges and solutions for treatment resistance.
Author:	Zhai, Zhenhua\|Yu, Xiaohui\|Yang, Bin\|Zhang, Yunjing\|Zhang, Long\|Li, Xiaoli\|Sun, Hongzhi
PMID:	27578007

506.
Journal:	Future Oncol. 2017 Jan;13(2):135-144.
Title:	Comparison of the molecular profile of brain metastases from colorectal cancer and corresponding primary tumors.
Author:	Aprile, Giuseppe\|Casagrande, Mariaelena\|De Maglio, Giovanna\|Fontanella, Caterina\|Rihawi, Karim\|Bonotto, Marta\|Pisa, Federica E\|Tuniz, Francesco\|Pizzolitto, Stefano\|Fasola, Gianpiero
PMID:	27578453

507.
Journal:	Semin Cell Dev Biol. 2017 Apr;64:58-64.
Title:	Gene heterogeneity in metastasis of colorectal cancer to the lung.
Author:	Hou, Jiayun\|Zhang, Yong\|Zhu, Zhitu
PMID:	27590223

508.
Journal:	Mod Pathol. 2017 Jan;30(1):113-122.
Title:	Colorectal carcinomas with submucosal invasion (pT1): analysis of histopathological and molecular factors predicting lymph node metastasis.
Author:	Pai, Reetesh K\|Cheng, Yu-Wei\|Jakubowski, Maureen A\|Shadrach, Bonnie L\|Plesec, Thomas P\|Pai, Rish K
PMID:	27713420

509.
Journal:	Intern Med J. 2017 Jan;47(1):88-98.
Title:	Examining the impact of regular aspirin use and PIK3CA mutations on survival in stage 2 colon cancer.
Author:	Murphy, Caitlin\|Turner, Natalie\|Wong, Hui-Li\|Sinnathamby, Mathu\|Tie, Jeanne\|Lee, Belinda\|Desai, Jayesh\|Skinner, Iain\|Christie, Michael\|Hutchinson, Ryan\|Lunke, Sebastian\|Waring, Paul\|Gibbs, Peter\|Tran, Ben
PMID:	27800646

510.
Journal:	Int J Cancer. 2017 Feb 15;140(4):922-929.
Title:	EGFR gene copy number predicts response to anti-EGFR treatment in RAS wild type and RAS/BRAF/PIK3CA wild type metastatic colorectal cancer.
Author:	Algars, Annika\|Sundstrom, Jari\|Lintunen, Minnamaija\|Jokilehto, Terhi\|Kytola, Soili\|Kaare, Milja\|Vainionpaa, Reetta\|Orpana, Arto\|Osterlund, Pia\|Ristimaki, Ari\|Carpen, Olli\|Ristamaki, Raija
PMID:	27879995

511.
Journal:	Mod Pathol. 2017 Apr;30(4):599-609.
Title:	Morphological characterization of colorectal cancers in The Cancer Genome Atlas reveals distinct morphology-molecular associations: clinical and biological implications.
Author:	Shia, Jinru\|Schultz, Nikolaus\|Kuk, Deborah\|Vakiani, Efsevia\|Middha, Sumit\|Segal, Neil H\|Hechtman, Jaclyn F\|Berger, Michael F\|Stadler, Zsofia K\|Weiser, Martin R\|Wolchok, Jedd D\|Boland, C Richard\|Gonen, Mithat\|Klimstra, David S
PMID:	27982025

512.
Journal:	Oncotarget. 2017 Jan 31;8(5):7852-7866.
Title:	Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer.
Author:	Ashktorab, Hassan\|Mokarram, Pooneh\|Azimi, Hamed\|Olumi, Hasti\|Varma, Sudhir\|Nickerson, Michael L\|Brim, Hassan
PMID:	28002797

513.
Journal:	Hum Pathol. 2017 Apr;62:91-98.
Title:	Analysis of KRAS, NRAS, PIK3CA, and BRAF mutational profile in poorly differentiated clusters of KRAS-mutated colon cancer.
Author:	Reggiani Bonetti, Luca\|Barresi, Valeria\|Bettelli, Stefania\|Caprera, Cecilia\|Manfredini, Samantha\|Maiorana, Antonio
PMID:	28025078

514.
Journal:	Cancer Chemother Pharmacol. 2017 Feb;79(2):389-397.
Title:	Molecular explorations of substituted 2-(4-phenylquinolin-2-yl) phenols as phosphoinositide 3-kinase inhibitors and anticancer agents.
Author:	Alagumuthu, Manikandan\|Arumugam, Sivakumar
PMID:	28054203

515.
Journal:	BMC Cancer. 2017 Jan 9;17(1):38.
Title:	Retrospective study of RAS/PIK3CA/BRAF tumor mutations as predictors of response to first-line chemotherapy with bevacizumab in metastatic colorectal cancer patients.
Author:	Nakayama, Izuma\|Shinozaki, Eiji\|Matsushima, Tomohiro\|Wakatsuki, Takeru\|Ogura, Mariko\|Ichimura, Takashi\|Ozaka, Masato\|Takahari, Daisuke\|Suenaga, Mitsukuni\|Chin, Keisho\|Mizunuma, Nobuyuki\|Yamaguchi, Kensei
PMID:	28068936

516.
Journal:	Int J Mol Sci. 2017 Jan 19;18(1). pii: ijms18010197.
Title:	Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer.
Author:	Marmol, Ines\|Sanchez-de-Diego, Cristina\|Pradilla Dieste, Alberto\|Cerrada, Elena\|Rodriguez Yoldi, Maria Jesus
PMID:	28106826

517.
Journal:	PLoS One. 2017 Jan 20;12(1):e0170551.
Title:	Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway.
Author:	Soo, Hsien-Chuen\|Chung, Felicia Fei-Lei\|Lim, Kuan-Hon\|Yap, Veronica Alicia\|Bradshaw, Tracey D\|Hii, Ling-Wei\|Tan, Si-Hoey\|See, Sze-Jia\|Tan, Yuen-Fen\|Leong, Chee-Onn\|Mai, Chun-Wai
PMID:	28107519

518.
Journal:	J Clin Pathol. 2017 Aug;70(8):702-711.
Title:	QMC-PCRx: a novel method for rapid mutation detection.
Author:	Ebili, Henry O\|Hassall, James\|Asiri, Abutaleb\|Ham-Karim, Hersh\|Fadhil, Wakkas\|Agboola, Ayodeji Johnson\|Ilyas, Mohammad
PMID:	28153952

519.
Journal:	Cancer Prev Res (Phila). 2017 Mar;10(3):208-218.
Title:	Aspirin-Induced Chemoprevention and Response Kinetics Are Enhanced by PIK3CA Mutations in Colorectal Cancer Cells.
Author:	Zumwalt, Timothy J\|Wodarz, Dominik\|Komarova, Natalia L\|Toden, Shusuke\|Turner, Jacob\|Cardenas, Jacob\|Burn, John\|Chan, Andrew T\|Boland, C Richard\|Goel, Ajay
PMID:	28154202

520.
Journal:	Oncotarget. 2017 Jan 24;8(4):6579-6588.
Title:	Whole-exome sequencing identified mutational profiles of high-grade colon adenomas.
Author:	Lee, Sung Hak\|Jung, Seung Hyun\|Kim, Tae-Min\|Rhee, Je-Keun\|Park, Hyeon-Chun\|Kim, Min Sung\|Kim, Sung Soo\|An, Chang Hyeok\|Lee, Sug Hyung\|Chung, Yeun-Jun
PMID:	28179590

521.
Journal:	Mol Cancer Res. 2017 Feb 9;15(3):317-327.
Title:	Dual PI3K/mTOR Inhibition in Colorectal Cancers with APC and PIK3CA Mutations.
Author:	Foley, Tyler M\|Payne, Susan N\|Pasch, Cheri A\|Yueh, Alex E\|Van De Hey, Dana R\|Korkos, Demetra P\|Clipson, Linda\|Maher, Molly E\|Matkowskyj, Kristina A\|Newton, Michael A\|Deming, Dustin A
PMID:	28184015

522.
Journal:	Hum Pathol. 2017 Jul;65:21-30.
Title:	KRAS and PIK3CA mutations in colorectal adenocarcinomas correlate with aggressive histological features and behavior.
Author:	Jang, Sejin\|Hong, Mineui\|Shin, Mi Kyung\|Kim, Byung Chun\|Shin, Hyung-Sik\|Yu, Eunsil\|Hong, Seung-Mo\|Kim, Jihun\|Chun, Sung-Min\|Kim, Tae-Im\|Choi, Kyung-Chan\|Ko, Young Woong\|Kim, Jeong Won
PMID:	28188750

523.
Journal:	Oncotarget. 2017 Mar 7;8(10):17164-17190.
Title:	ATM mutations and E-cadherin expression define sensitivity to EGFR-targeted therapy in colorectal cancer.
Author:	Geissler, Anna-Lena\|Geissler, Miriam\|Kottmann, Daniel\|Lutz, Lisa\|Fichter, Christiane D\|Fritsch, Ralph\|Weddeling, Britta\|Makowiec, Frank\|Werner, Martin\|Lassmann, Silke
PMID:	28199979

524.
Journal:	Tumour Biol. 2017 Feb;39(2):1010428317692265.
Title:	Prevalence and coexistence of KRAS, BRAF, PIK3CA, NRAS, TP53, and APC mutations in Indian colorectal cancer patients: Next-generation sequencing-based cohort study.
Author:	Jauhri, Mayank\|Bhatnagar, Akanksha\|Gupta, Satish\|Bp, Manasa\|Minhas, Sachin\|Shokeen, Yogender\|Aggarwal, Shyam
PMID:	28222664

525.
Journal:	J Cancer. 2017 Jan 12;8(2):162-173.
Title:	Construction of a multiplex mutation hot spot PCR panel: the first step towards colorectal cancer genotyping on the GS Junior platform.
Author:	Peterfia, Balint\|Kalmar, Alexandra\|Patai, Arpad V\|Csabai, Istvan\|Bodor, Andras\|Micsik, Tamas\|Wichmann, Barnabas\|Egedi, Krisztina\|Hollosi, Peter\|Kovalszky, Ilona\|Tulassay, Zsolt\|Molnar, Bela
PMID:	28243320

526.
Journal:	Mol Diagn Ther. 2017 Aug;21(4):443-451.
Title:	Detection of PIK3CA Mutations in Plasma DNA of Colorectal Cancer Patients by an Ultra-Sensitive PNA-Mediated PCR.
Author:	Zeng, Qian\|Xie, Li\|Zhou, Na\|Liu, Min\|Song, Xianrang
PMID:	28247181

527.
Journal:	Int J Cancer. 2017 Jun 15;140(12):2648-2656.
Title:	Dietary glycemic and insulin scores and colorectal cancer survival by tumor molecular biomarkers.
Author:	Keum, NaNa\|Yuan, Chen\|Nishihara, Reiko\|Zoltick, Emilie\|Hamada, Tsuyoshi\|Martinez Fernandez, Alejandro\|Zhang, Xuehong\|Hanyuda, Akiko\|Liu, Li\|Kosumi, Keisuke\|Nowak, Jonathan A\|Jhun, Iny\|Soong, T Rinda\|Morikawa, Teppei\|Tabung, Fred K\|Qian, Zhi Rong\|Fuchs, Ch
PMID:	28268248

528.
Journal:	J Gastrointest Oncol. 2017 Feb;8(1):164-172.
Title:	Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis.
Author:	Borazanci, Erkut\|Millis, Sherri Z\|Kimbrough, Jeffery\|Doll, Nancy\|Von Hoff, Daniel\|Ramanathan, Ramesh K
PMID:	28280620

529.
Journal:	J Gastrointest Oncol. 2017 Feb;8(1):199-212.
Title:	Current companion diagnostics in advanced colorectal cancer; getting a bigger and better piece of the pie.
Author:	Loree, Jonathan M\|Kopetz, Scott\|Raghav, Kanwal P S
PMID:	28280626

530.
Journal:	Ann Oncol. 2017 Jun 1;28(6):1359-1367.
Title:	Predicted vitamin D status and colon cancer recurrence and mortality in CALGB 89803 (Alliance).
Author:	Fuchs, M A\|Yuan, C\|Sato, K\|Niedzwiecki, D\|Ye, X\|Saltz, L B\|Mayer, R J\|Mowat, R B\|Whittom, R\|Hantel, A\|Benson, A\|Atienza, D\|Messino, M\|Kindler, H\|Venook, A\|Innocenti, F\|Warren, R S\|Bertagnolli, M M\|Ogino, S\|Giovannucci, E L\|Horvath, E\|Meyerhardt, J A\|Ng, K
PMID:	28327908

531.
Journal:	Tumour Biol. 2017 Mar;39(3):1010428317692246.
Title:	Mitochondrial DNA alteration in primary and metastatic colorectal cancer: Different frequency and association with selected clinicopathological and molecular markers.
Author:	Kleist, Britta\|Meurer, Thuja\|Poetsch, Micaela
PMID:	28345467

532.
Journal:	Ann Surg. 2017 Apr 4.
Title:	APC and PIK3CA Mutational Cooperativity Predicts Pathologic Response and Survival in Patients Undergoing Resection for Colorectal Liver Metastases.
Author:	Yamashita, Suguru\|Chun, Yun-Shin\|Kopetz, Scott E\|Maru, Dipen\|Conrad, Claudius\|Aloia, Thomas A\|Vauthey, Jean-Nicolas
PMID:	28379870

533.
Journal:	Oncoimmunology. 2017 Jan 31;6(3):e1284720.
Title:	Tumor SQSTM1 (p62) expression and T cells in colorectal cancer.
Author:	Kosumi, Keisuke\|Masugi, Yohei\|Yang, Juhong\|Qian, Zhi Rong\|Kim, Sun A\|Li, Wanwan\|Shi, Yan\|da Silva, Annacarolina\|Hamada, Tsuyoshi\|Liu, Li\|Gu, Mancang\|Twombly, Tyler S\|Cao, Yin\|Barbie, David A\|Nosho, Katsuhiko\|Baba, Hideo\|Garrett, Wendy S\|Meyerhardt, Jeffer
PMID:	28405513

534.
Journal:	J Clin Oncol. 2017 Jun 1;35(16):1836-1844.
Title:	Aspirin Use and Colorectal Cancer Survival According to Tumor CD274 (Programmed Cell Death 1 Ligand 1) Expression Status.
Author:	Hamada, Tsuyoshi\|Cao, Yin\|Qian, Zhi Rong\|Masugi, Yohei\|Nowak, Jonathan A\|Yang, Juhong\|Song, Mingyang\|Mima, Kosuke\|Kosumi, Keisuke\|Liu, Li\|Shi, Yan\|da Silva, Annacarolina\|Gu, Mancang\|Li, Wanwan\|Keum, NaNa\|Zhang, Xuehong\|Wu, Kana\|Meyerhardt, Jeffrey A\|Giova
PMID:	28406723

535.
Journal:	Oncotarget. 2017 Apr 4;8(14):22305-22306.
Title:	PIK3CA mutation and colorectal cancer precision medicine.
Author:	Hamada, Tsuyoshi\|Nowak, Jonathan A\|Ogino, Shuji
PMID:	28423591

536.
Journal:	Oncotarget. 2017 Jun 13;8(24):39268-39279.
Title:	FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma.
Author:	Korphaisarn, Krittiya\|Morris, Van Karlyle\|Overman, Michael J\|Fogelman, David R\|Kee, Bryan K\|Raghav, Kanwal Pratap Singh\|Manuel, Shanequa\|Shureiqi, Imad\|Wolff, Robert A\|Eng, Cathy\|Menter, David\|Hamilton, Stanley R\|Kopetz, Scott\|Dasari, Arvind
PMID:	28424412

537.
Journal:	J Cell Biol. 2017 Jun 5;216(6):1567-1577.
Title:	Oncogenic beta-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids.
Author:	Riemer, Pamela\|Rydenfelt, Mattias\|Marks, Matthias\|van Eunen, Karen\|Thedieck, Kathrin\|Herrmann, Bernhard G\|Bluthgen, Nils\|Sers, Christine\|Morkel, Markus
PMID:	28442534

538.
Journal:	Acta Oncol. 2017 May;56(5):639-645.
Title:	Risk factors for brain metastases in patients with metastatic colorectal cancer.
Author:	Christensen, Troels Dreier\|Palshof, Jesper Andreas\|Larsen, Finn Ole\|Hogdall, Estrid\|Poulsen, Tim Svenstrup\|Pfeiffer, Per\|Jensen, Benny Vittrup\|Yilmaz, Mette Karen\|Christensen, Ib Jarle\|Nielsen, Dorte
PMID:	28447565

539.
Journal:	Clin Transl Gastroenterol. 2017 Apr 27;8(4):e91.
Title:	Evaluation of PTGS2 Expression, PIK3CA Mutation, Aspirin Use and Colon Cancer Survival in a Population-Based Cohort Study.
Author:	Gray, Ronan T\|Cantwell, Marie M\|Coleman, Helen G\|Loughrey, Maurice B\|Bankhead, Peter\|McQuaid, Stephen\|O'Neill, Roisin F\|Arthur, Kenneth\|Bingham, Victoria\|McGready, Claire\|Gavin, Anna T\|Cardwell, Chris R\|Johnston, Brian T\|James, Jacqueline A\|Hamilton, Pete
PMID:	28448072

540.
Journal:	PLoS One. 2017 May 1;12(5):e0176340.
Title:	Feasibility of multiplexed gene mutation detection in plasma samples of colorectal cancer patients by mass spectrometric genotyping.
Author:	Shin, Su-Jin\|Chun, Sung-Min\|Kim, Tae-Im\|Kim, Yu Jin\|Choi, Hyun-Jeung\|Jang, Se Jin\|Kim, Jihun
PMID:	28459822

541.
Journal:	Oncotarget. 2017 Jun 27;8(26):42487-42494.
Title:	Local recurrences at the anastomotic area are clonally related to the primary tumor in sporadic colorectal carcinoma.
Author:	Vakiani, Efsevia\|Shah, Ronak H\|Berger, Michael F\|Makohon-Moore, Alvin P\|Reiter, Johannes G\|Ostrovnaya, Irina\|Attiyeh, Marc A\|Cercek, Andrea\|Shia, Jinru\|Iacobuzio-Donahue, Christine A\|Solit, David B\|Weiser, Martin R
PMID:	28476018

542.
Journal:	Cancer. 2017 Sep 15;123(18):3513-3523.
Title:	Association between mutations of critical pathway genes and survival outcomes according to the tumor location in colorectal cancer.
Author:	Lee, Dae-Won\|Han, Sae-Won\|Cha, Yongjun\|Bae, Jeong Mo\|Kim, Hwang-Phill\|Lyu, Jaemyun\|Han, Hyojun\|Kim, Hyoki\|Jang, Hoon\|Bang, Duhee\|Huh, Iksoo\|Park, Taesung\|Won, Jae-Kyung\|Jeong, Seung-Yong\|Park, Kyu Joo\|Kang, Gyeong Hoon\|Kim, Tae-You
PMID:	28513830

543.
Journal:	Br J Cancer. 2017 Jun 27;117(1):136-143.
Title:	Targeted sequencing-based analyses of candidate gene variants in ulcerative colitis-associated colorectal neoplasia.
Author:	Chakrabarty, Sanjiban\|Varghese, Vinay Koshy\|Sahu, Pranoy\|Jayaram, Pradyumna\|Shivakumar, Bhadravathi M\|Pai, Cannanore Ganesh\|Satyamoorthy, Kapaettu
PMID:	28524162

544.
Journal:	Int J Mol Sci. 2017 May 23;18(6). pii: ijms18061106.
Title:	Emergence of CD26+ Cancer Stem Cells with Metastatic Properties in Colorectal Carcinogenesis.
Author:	Cheung, Alvin Ho-Kwan\|Iyer, Deepak Narayanan\|Lam, Colin Siu-Chi\|Ng, Lui\|Wong, Sunny K M\|Lee, Hung-Sing\|Wan, Timothy\|Man, Johnny\|Chow, Ariel K M\|Poon, Ronnie T\|Pang, Roberta\|Law, Wai-Lun
PMID:	28545226

545.
Journal:	EBioMedicine. 2017 Jun;20:39-49.
Title:	A Specific Mutational Signature Associated with DNA 8-Oxoguanine Persistence in MUTYH-defective Colorectal Cancer.
Author:	Viel, Alessandra\|Bruselles, Alessandro\|Meccia, Ettore\|Fornasarig, Mara\|Quaia, Michele\|Canzonieri, Vincenzo\|Policicchio, Eleonora\|Urso, Emanuele Damiano\|Agostini, Marco\|Genuardi, Maurizio\|Lucci-Cordisco, Emanuela\|Venesio, Tiziana\|Martayan, Aline\|Diodoro, M
PMID:	28551381

546.
Journal:	JAMA Oncol. 2017 Nov 1;3(11):1546-1553.
Title:	Genomic Profiling of Small-Bowel Adenocarcinoma.
Author:	Schrock, Alexa B\|Devoe, Craig E\|McWilliams, Robert\|Sun, James\|Aparicio, Thomas\|Stephens, Philip J\|Ross, Jeffrey S\|Wilson, Richard\|Miller, Vincent A\|Ali, Siraj M\|Overman, Michael J
PMID:	28617917

547.
Journal:	Mol Oncol. 2017 Sep;11(9):1263-1272.
Title:	Analysis of mutant allele fractions in driver genes in colorectal cancer - biological and clinical insights.
Author:	Dienstmann, Rodrigo\|Elez, Elena\|Argiles, Guillem\|Matos, Ignacio\|Sanz-Garcia, Enrique\|Ortiz, Carolina\|Macarulla, Teresa\|Capdevila, Jaume\|Alsina, Maria\|Sauri, Tamara\|Verdaguer, Helena\|Vilaro, Marta\|Ruiz-Pace, Fiorella\|Viaplana, Cristina\|Garcia, Ariadna\|Land
PMID:	28618197

548.
Journal:	Tumour Biol. 2017 Jul;39(7):1010428317709638.
Title:	Oncogene mutation profile predicts tumor regression and survival in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy and radical surgery.
Author:	Peng, Jianhong\|Lin, Junzhong\|Qiu, Miaozhen\|Zhao, Yujie\|Deng, Yuxiang\|Shao, Jianyong\|Ding, Peirong\|Zhang, Huizhong\|Wan, Desen\|Lu, Zhenhai\|Pan, Zhizhong
PMID:	28671043

549.
Journal:	Int J Mol Sci. 2017 Jul 5;18(7). pii: ijms18071441.
Title:	Molecular and Clinicopathological Differences by Age at the Diagnosis of Colorectal Cancer.
Author:	Chang, Chu-Cheng\|Lin, Pei-Ching\|Lin, Chun-Chi\|Lan, Yuan-Tzu\|Lin, Hung-Hsin\|Lin, Chien-Hsing\|Yang, Shung-Haur\|Liang, Wen-Yi\|Chen, Wei-Shone\|Jiang, Jeng-Kai\|Lin, Jen-Kou\|Chang, Shih-Ching
PMID:	28678173

550.
Journal:	Mol Clin Oncol. 2017 Jul;7(1):113-120.
Title:	Heterogeneity in the colorectal primary tumor and the synchronous resected liver metastases prior to and after treatment with an anti-EGFR monoclonal antibody.
Author:	Adua, Daniela\|Di Fabio, Francesca\|Ercolani, Giorgio\|Fiorentino, Michelangelo\|Gruppioni, Elisa\|Altimari, Annalisa\|Rojas Limpe, Fabiola Lorena\|Normanno, Nicola\|Pinna, Antonio Daniele\|Pinto, Carmine
PMID:	28685087

551.
Journal:	Cell Rep. 2017 Jul 25;20(4):999-1015.
Title:	A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution.
Author:	Anderson, Grace R\|Winter, Peter S\|Lin, Kevin H\|Nussbaum, Daniel P\|Cakir, Merve\|Stein, Elizabeth M\|Soderquist, Ryan S\|Crawford, Lorin\|Leeds, Jim C\|Newcomb, Rachel\|Stepp, Priya\|Yip, Catherine\|Wardell, Suzanne E\|Tingley, Jennifer P\|Ali, Moiez\|Xu, Mengmeng\|Ry
PMID:	28746882

552.
Journal:	J Biomol Tech. 2017 Sep;28(3):97-110.
Title:	Squirrel Primer-Based PCR Assay for Direct and Targeted Sanger Sequencing of Short Genomic Segments.
Author:	Ebili, Henry O\|Hassall, James C\|Fadhil, Wakkas\|Ham-Karim, Hersh\|Asiri, Abutaleb\|Raposo, Teresa P\|Agboola, Ayodeji Johnson\|Ilyas, Mohammad
PMID:	28785174

553.
Journal:	Int J Mol Sci. 2017 Aug 29;18(9). pii: ijms18091871.
Title:	Measurement of Telomere Length in Colorectal Cancers for Improved Molecular Diagnosis.
Author:	Balc'h, Eric Le\|Grandin, Nathalie\|Demattei, Marie-Veronique\|Guyetant, Serge\|Tallet, Anne\|Pages, Jean-Christophe\|Ouaissi, Mehdi\|Lecomte, Thierry\|Charbonneau, Michel
PMID:	28850092

554.
Journal:	Int J Cancer. 2017 Dec 15;141(12):2471-2479.
Title:	Tumor expression of calcium sensing receptor and colorectal cancer survival: Results from the nurses' health study and health professionals follow-up study.
Author:	Momen-Heravi, Fatemeh\|Masugi, Yohei\|Qian, Zhi Rong\|Nishihara, Reiko\|Liu, Li\|Smith-Warner, Stephanie A\|Keum, NaNa\|Zhang, Lanjing\|Tchrakian, Nairi\|Nowak, Jonathan A\|Yang, Wanshui\|Ma, Yanan\|Bowden, Michaela\|da Silva, Annacarolina\|Wang, Molin\|Fuchs, Charles S
PMID:	28856682

555.
Journal:	Br J Cancer. 2017 Oct 24;117(9):1286-1294.
Title:	Preoperative chemoradiation with capecitabine, irinotecan and cetuximab in rectal cancer: significance of pre-treatment and post-resection RAS mutations.
Author:	Gollins, Simon\|West, Nick\|Sebag-Montefiore, David\|Myint, Arthur Sun\|Saunders, Mark\|Susnerwala, Shabbir\|Quirke, Phil\|Essapen, Sharadah\|Samuel, Leslie\|Sizer, Bruce\|Worlding, Jane\|Southward, Katie\|Hemmings, Gemma\|Tinkler-Hundal, Emma\|Taylor, Morag\|Bottomley,
PMID:	28859058

556.
Journal:	Oncotarget. 2017 Jun 14;8(34):57845-57854.
Title:	Implementation and utilization of the molecular tumor board to guide precision medicine.
Author:	Harada, Shuko\|Arend, Rebecca\|Dai, Qian\|Levesque, Jessica A\|Winokur, Thomas S\|Guo, Rongjun\|Heslin, Martin J\|Nabell, Lisle\|Nabors, L Burt\|Limdi, Nita A\|Roth, Kevin A\|Partridge, Edward E\|Siegal, Gene P\|Yang, Eddy S
PMID:	28915716

557.
Journal:	J Cancer. 2017 Aug 22;8(14):2713-2719.
Title:	The Impact of Cetuximab Plus AKT- or mTOR- Inhibitor in a Patient-Derived Colon Cancer Cell Model with Wild-Type RAS and PIK3CA Mutation.
Author:	Kim, Ju Sun\|Kim, Jung Eun\|Kim, Kyung\|Lee, Jeeyun\|Park, Joon Oh\|Lim, Ho Yeong\|Park, Young Suk\|Kang, Won Ki\|Kim, Seung Tae
PMID:	28928860

558.
Journal:	Tumour Biol. 2017 Sep;39(9):1010428317724517.
Title:	EGFR pathway subgroups in Chilean colorectal cancer patients, detected by mutational and expression profiles, associated to different clinicopathological features.
Author:	Alvarez, Karin\|Orellana, Paulina\|Villarroel, Cynthia\|Contreras, Luis\|Kawachi, Hiroshi\|Kobayashi, Maki\|Wielandt, Ana Maria\|De la Fuente, Marjorie\|Trivino, Juan Carlos\|Kronberg, Udo\|Carvallo, Pilar\|Lopez-Kostner, Francisco
PMID:	28936923

559.
Journal:	Clin Cancer Res. 2017 Dec 1;23(23):7209-7216.
Title:	Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer.
Author:	Joung, Je-Gun\|Oh, Bo Young\|Hong, Hye Kyung\|Al-Khalidi, Hisham\|Al-Alem, Faisal\|Lee, Hae-Ock\|Bae, Joon Seol\|Kim, Jinho\|Cha, Hong-Ui\|Alotaibi, Maram\|Cho, Yong Beom\|Hassanain, Mazen\|Park, Woong-Yang\|Lee, Woo Yong
PMID:	28939741

560.
Journal:	Cancer Lett. 2017 Dec 1;410:92-99.
Title:	Major challenges related to tumor biological characteristics in accurate mutation detection of colorectal cancer by next-generation sequencing.
Author:	Li, Weihua\|Qiu, Tian\|Guo, Lei\|Ying, Jianming
PMID:	28942013

561.
Journal:	Cancer Immunol Res. 2017 Nov;5(11):1046-1055.
Title:	Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer.
Author:	Masugi, Yohei\|Nishihara, Reiko\|Hamada, Tsuyoshi\|Song, Mingyang\|da Silva, Annacarolina\|Kosumi, Keisuke\|Gu, Mancang\|Shi, Yan\|Li, Wanwan\|Liu, Li\|Nevo, Daniel\|Inamura, Kentaro\|Cao, Yin\|Liao, Xiaoyun\|Nosho, Katsuhiko\|Chan, Andrew T\|Giannakis, Marios\|Bass, Adam
PMID:	29038297

562.
Journal:	Oncotarget. 2017 Aug 21;8(42):72352-72362.
Title:	Acquired somatic TP53 or PIK3CA mutations are potential predictors of when polyps evolve into colorectal cancer.
Author:	Chang, Pi-Yueh\|Chen, Jinn-Shiun\|Chang, Shih-Cheng\|Wang, Mei-Chia\|Chang, Nai-Chung\|Wen, Ying-Hao\|Tsai, Wen-Sy\|Liu, Wei-Hsiu\|Liu, Hsiu-Ling\|Lu, Jang-Jih
PMID:	29069792

563.
Journal:	Cancer Med. 2017 Dec;6(12):2966-2971.
Title:	POLE somatic mutations in advanced colorectal cancer.
Author:	Guerra, Joana\|Pinto, Carla\|Pinto, Diana\|Pinheiro, Manuela\|Silva, Romina\|Peixoto, Ana\|Rocha, Patricia\|Veiga, Isabel\|Santos, Catarina\|Santos, Rui\|Cabreira, Veronica\|Lopes, Paula\|Henrique, Rui\|Teixeira, Manuel R
PMID:	29072370

564.
Journal:	Ann Surg Treat Res. 2017 Oct;93(4):173-180.
Title:	Establishing a colorectal cancer liver metastasis patient-derived tumor xenograft model for the evaluation of personalized chemotherapy.
Author:	Jung, Joohee\|Kim, Jisup\|Lim, Hyun Kyung\|Kim, Kyoung Mee\|Lee, Yun Sun\|Park, Joon Seong\|Yoon, Dong Sup
PMID:	29094026

565.
Journal:	Oncotarget. 2017 Sep 28;8(48):84426-84433.
Title:	Tumor-biopsy stratification based on mTOR-pathway activity and functional mutations in the upstream genes PIK3CA and PTEN.
Author:	Laes, Jean-Francois\|Sauvage, Sebastien\|Ghitti, Gregori
PMID:	29137436

566.
Journal:	Oncotarget. 2017 Sep 18;8(50):87379-87389.
Title:	Aspirin exerts high anti-cancer activity in PIK3CA-mutant colon cancer cells.
Author:	Gu, Mancang\|Nishihara, Reiko\|Chen, Yang\|Li, Wanwan\|Shi, Yan\|Masugi, Yohei\|Hamada, Tsuyoshi\|Kosumi, Keisuke\|Liu, Li\|da Silva, Annacarolina\|Nowak, Jonathan A\|Twombly, Tyler\|Du, Chunxia\|Koh, Hideo\|Li, Wenbin\|Meyerhardt, Jeffrey A\|Wolpin, Brian M\|Giannakis, M
PMID:	29152088

567.
Journal:	Oncotarget. 2017 Sep 21;8(49):86356-86368.
Title:	Comparative molecular analyses of left-sided colon, right-sided colon, and rectal cancers.
Author:	Salem, Mohamed E\|Weinberg, Benjamin A\|Xiu, Joanne\|El-Deiry, Wafik S\|Hwang, Jimmy J\|Gatalica, Zoran\|Philip, Philip A\|Shields, Anthony F\|Lenz, Heinz-Josef\|Marshall, John L
PMID:	29156800

568.
Journal:	BMC Gastroenterol. 2017 Nov 23;17(1):121.
Title:	Primary tumor location predicts poor clinical outcome with cetuximab in RAS wild-type metastatic colorectal cancer.
Author:	Kim, Dalyong\|Kim, Sun Young\|Lee, Ji Sung\|Hong, Yong Sang\|Kim, Jeong Eun\|Kim, Kyu-Pyo\|Kim, Jihun\|Jang, Se Jin\|Yoon, Young-Kwang\|Kim, Tae Won
PMID:	29169325

569.
Journal:	Oncotarget. 2017 Aug 24;8(55):93567-93579.
Title:	Comprehensive genomic sequencing detects important genetic differences between right-sided and left-sided colorectal cancer.
Author:	Shimada, Yoshifumi\|Kameyama, Hitoshi\|Nagahashi, Masayuki\|Ichikawa, Hiroshi\|Muneoka, Yusuke\|Yagi, Ryoma\|Tajima, Yosuke\|Okamura, Takuma\|Nakano, Masato\|Sakata, Jun\|Kobayashi, Takashi\|Nogami, Hitoshi\|Maruyama, Satoshi\|Takii, Yasumasa\|Hayashida, Tetsu\|Takaishi
PMID:	29212173

570.
Journal:	Nat Commun. 2017 Dec 8;8(1):1998.
Title:	Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.
Author:	Baker, Ann-Marie\|Huang, Weini\|Wang, Xiao-Ming Mindy\|Jansen, Marnix\|Ma, Xiao-Jun\|Kim, Jeffrey\|Anderson, Courtney M\|Wu, Xingyong\|Pan, Liuliu\|Su, Nan\|Luo, Yuling\|Domingo, Enric\|Heide, Timon\|Sottoriva, Andrea\|Lewis, Annabelle\|Beggs, Andrew D\|Wright, Nicholas
PMID:	29222441

571.
Journal:	Oncotarget. 2017 Sep 27;8(62):105072-105080.
Title:	Targeted next generation sequencing in Chinese colorectal cancer patients guided anti-EGFR treatment and facilitated precision cancer medicine.
Author:	Hou, Helei\|Liu, Dong\|Zhang, Chuantao\|Jiang, Yanxia\|Lu, Guifang\|Zhou, Na\|Yang, Xiaonan\|Zhang, Xiaoping\|Li, Zhuokun\|Zhu, Hongmei\|Qian, Zhaoyang\|Zhang, Xiaochun
PMID:	29285234

572.
Journal:	NPJ Precis Oncol. 2017;1.
Title:	Integration of pharmacology, molecular pathology, and population data science to support precision gastrointestinal oncology.
Author:	Ogino, Shuji\|Jhun, Iny\|Mata, Douglas A\|Soong, Thing Rinda\|Hamada, Tsuyoshi\|Liu, Li\|Nishihara, Reiko\|Giannakis, Marios\|Cao, Yin\|Manson, JoAnn E\|Nowak, Jonathan A\|Chan, Andrew T
PMID:	29552640

573.
Journal:	Mol Cell Biochem. 2018 Feb;439(1-2):199-211.
Title:	Insulin-like growth factor-1 activates different catalytic subunits p110 of PI3K in a cell-type-dependent manner to induce lipogenesis-dependent epithelial-mesenchymal transition through the regulation of ADAM10 and ADAM17.
Author:	Park, Ga Bin\|Kim, Daejin
PMID:	28819788

574.
Journal:	Mod Pathol. 2018 Feb;31(2):343-349.
Title:	Optimal detection of clinically relevant mutations in colorectal carcinoma: sample pooling overcomes intra-tumoral heterogeneity.
Author:	Nelson, Andrew C\|Boone, Jamie\|Cartwright, David\|Thyagarajan, Bharat\|Kincaid, Robyn\|Lambert, Aaron P\|Karnuth, Kylene\|Henzler, Christine\|Yohe, Sophia
PMID:	29027537

575.
Journal:	Clin Colorectal Cancer. 2018 Mar;17(1):73-79.
Title:	Molecular Profiling of Patients With Advanced Colorectal Cancer: Princess Margaret Cancer Centre Experience.
Author:	Chiu, Joanne W\|Krzyzanowska, Monika K\|Serra, Stefano\|Knox, Jennifer J\|Dhani, Neesha C\|Mackay, Helen\|Hedley, David\|Moore, Malcolm\|Liu, Geoffrey\|Burkes, Ronald L\|Brezden-Masley, Christine\|Roehrl, Michael H\|Craddock, Kenneth J\|Tsao, Ming-Sound\|Zhang, Tong\|Yu
PMID:	29128266

576.
Journal:	Bull Cancer. 2018 Feb;105(2):171-180.
Title:	[Aspirin and colorectal cancer].
Author:	Grancher, Adrien\|Michel, Pierre\|Di Fiore, Frederic\|Sefrioui, David
PMID:	29153543

577.
Journal:	Clin Cancer Res. 2018 Mar 1;24(5):1062-1072.
Title:	Classifying Colorectal Cancer by Tumor Location Rather than Sidedness Highlights a Continuum in Mutation Profiles and Consensus Molecular Subtypes.
Author:	Loree, Jonathan M\|Pereira, Allan A L\|Lam, Michael\|Willauer, Alexandra N\|Raghav, Kanwal\|Dasari, Arvind\|Morris, Van K\|Advani, Shailesh\|Menter, David G\|Eng, Cathy\|Shaw, Kenna\|Broaddus, Russell\|Routbort, Mark J\|Liu, Yusha\|Morris, Jeffrey S\|Luthra, Rajyalakshm
PMID:	29180604

578.
Journal:	Mol Carcinog. 2018 Mar;57(3):451-461.
Title:	Molecular profiling and genome-wide analysis based on somatic copy number alterations in advanced colorectal cancers.
Author:	Sugai, Tamotsu\|Takahashi, Yayoi\|Eizuka, Makoto\|Sugimoto, Ryo\|Fujita, Yasuko\|Habano, Wataru\|Otsuka, Kouki\|Sasaki, Akira\|Yamamoto, Eiichiro\|Matsumoto, Takayuki\|Suzuki, Hiromu
PMID:	29230882

579.
Journal:	Lancet Gastroenterol Hepatol. 2018 Mar;3(3):162-171.
Title:	Inhibition of EGFR, HER2, and HER3 signalling in patients with colorectal cancer wild-type for BRAF, PIK3CA, KRAS, and NRAS (FOCUS4-D): a phase 2-3 randomised trial.
Author:	Adams, Richard\|Brown, Ewan\|Brown, Louise\|Butler, Rachel\|Falk, Stephen\|Fisher, David\|Kaplan, Richard\|Quirke, Phil\|Richman, Susan\|Samuel, Leslie\|Seligmann, Jenny\|Seymour, Matt\|Shiu, Kai Keen\|Wasan, Harpreet\|Wilson, Richard\|Maughan, Tim
PMID:	29254887

580.
Journal:	Oncologist. 2018 Mar;23(3):277-e26.
Title:	Phase II Study of Panitumumab in RAS Wild-Type Metastatic Adenocarcinoma of Small Bowel or Ampulla of Vater.
Author:	Gulhati, Pat\|Raghav, Kanwal\|Shroff, Rachna\|Varadhachary, Gauri\|Javle, Milind\|Qiao, Wei\|Wang, Huamin\|Morris, Jeffrey\|Wolff, Robert\|Overman, Michael J
PMID:	29259073

581.
Journal:	Adv Clin Chem. 2018;83:53-72.
Title:	Locked Nucleic Acid Technology for Highly Sensitive Detection of Somatic Mutations in Cancer.
Author:	Ishige, Takayuki\|Itoga, Sakae\|Matsushita, Kazuyuki
PMID:	29304903

582.
Journal:	Cancer Cell. 2018 Jan 8;33(1):125-136.e3.
Title:	Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer.
Author:	Yaeger, Rona\|Chatila, Walid K\|Lipsyc, Marla D\|Hechtman, Jaclyn F\|Cercek, Andrea\|Sanchez-Vega, Francisco\|Jayakumaran, Gowtham\|Middha, Sumit\|Zehir, Ahmet\|Donoghue, Mark T A\|You, Daoqi\|Viale, Agnes\|Kemeny, Nancy\|Segal, Neil H\|Stadler, Zsofia K\|Varghese, Anna
PMID:	29316426

583.
Journal:	Cancer Metastasis Rev. 2018 Mar;37(1):173-187.
Title:	Mutations of key driver genes in colorectal cancer progression and metastasis.
Author:	Huang, Dongdong\|Sun, Wenjie\|Zhou, Yuwei\|Li, Peiwei\|Chen, Fang\|Chen, Hanwen\|Xia, Dajing\|Xu, Enping\|Lai, Maode\|Wu, Yihua\|Zhang, Honghe
PMID:	29322354

584.
Journal:	Transl Oncol. 2018 Apr;11(2):213-220.
Title:	Significance of Liquid Biopsy for Monitoring and Therapy Decision of Colorectal Cancer.
Author:	Klein-Scory, Susanne\|Maslova, Marina\|Pohl, Michael\|Eilert-Micus, Christina\|Schroers, Roland\|Schmiegel, Wolff\|Baraniskin, Alexander
PMID:	29367069

585.
Journal:	Acta Oncol. 2018 Aug;57(8):1057-1062.
Title:	Associations between primary tumor RAS, BRAF and PIK3CA mutation status and metastatic site in patients with chemo-resistant metastatic colorectal cancer.
Author:	Christensen, Troels Dreier\|Palshof, Jesper Andreas\|Larsen, Finn Ole\|Poulsen, Tim Svenstrup\|Hogdall, Estrid\|Pfeiffer, Per\|Jensen, Benny Vittrup\|Yilmaz, Mette Karen\|Nielsen, Dorte
PMID:	29380640

586.
Journal:	J Gastrointest Cancer. 2018 Feb 1. pii: 10.1007/s12029-018-0062-y.
Title:	Clinical Impact of PI3K/BRAF Mutations in RAS Wild Metastatic Colorectal Cancer: Meta-analysis Results.
Author:	Mohamed, Amr\|Twardy, Brandon\|AbdAllah, Nadine\|Akhras, Alaa\|Ismail, Hibah\|Zordok, Magdi\|Schrapp, Kelly\|Attumi, Taraq\|Tesfaye, Anteneh\|El-Rayes, Bassel
PMID:	29388061

587.
Journal:	J Clin Oncol. 2018 May 1;36(13):1291-1299.
Title:	Phosphatidylinositol 3-Kinase alpha-Selective Inhibition With Alpelisib (BYL719) in PIK3CA-Altered Solid Tumors: Results From the First-in-Human Study.
Author:	Juric, Dejan\|Rodon, Jordi\|Tabernero, Josep\|Janku, Filip\|Burris, Howard A\|Schellens, Jan H M\|Middleton, Mark R\|Berlin, Jordan\|Schuler, Martin\|Gil-Martin, Marta\|Rugo, Hope S\|Seggewiss-Bernhardt, Ruth\|Huang, Alan\|Bootle, Douglas\|Demanse, David\|Blumenstein, L
PMID:	29401002

588.
Journal:	Oncotarget. 2017 Dec 15;9(3):3394-3405.
Title:	Copy number profiles of paired primary and metastatic colorectal cancers.
Author:	Kawamata, Futoshi\|Patch, Ann-Marie\|Nones, Katia\|Bond, Catherine\|McKeone, Diane\|Pearson, Sally-Ann\|Homma, Shigenori\|Liu, Cheng\|Fennell, Lochlan\|Dumenil, Troy\|Hartel, Gunter\|Kobayasi, Nozomi\|Yokoo, Hideki\|Fukai, Moto\|Nishihara, Hiroshi\|Kamiyama, Toshiya\|Bur
PMID:	29423054

589.
Journal:	World J Gastroenterol. 2018 Feb 7;24(5):631-640.
Title:	PIK3CA and TP53 mutations predict overall survival of stage II/III colorectal cancer patients.
Author:	Li, A-Jian\|Li, Hua-Guang\|Tang, Er-Jiang\|Wu, Wei\|Chen, Ying\|Jiang, Hui-Hong\|Lin, Mou-Bin\|Yin, Lu
PMID:	29434452

590.
Journal:	Oncol Lett. 2018 Mar;15(3):3197-3201.
Title:	mir-106a regulates cell proliferation and apoptosis of colon cancer cells through targeting the PTEN/PI3K/AKT signaling pathway.
Author:	Qin, Yan\|Huo, Zhibin\|Song, Xiang\|Chen, Xiao\|Tian, Xiaopeng\|Wang, Xinjie
PMID:	29435057

591.
Journal:	Cold Spring Harb Mol Case Stud. 2018 Apr 2;4(2). pii: mcs.a002535.
Title:	Molecular characterization of ERBB2-amplified colorectal cancer identifies potential mechanisms of resistance to targeted therapies: a report of two instructive cases.
Author:	Owen, Daniel R\|Wong, Hui-Li\|Bonakdar, Melika\|Jones, Martin\|Hughes, Christopher S\|Morin, Gregg B\|Jones, Steven J M\|Renouf, Daniel J\|Lim, Howard\|Laskin, Janessa\|Marra, Marco\|Yip, Stephen\|Schaeffer, David F
PMID:	29438965

592.
Journal:	Sci Rep. 2018 Feb 16;8(1):3161.
Title:	Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterations.
Author:	Druliner, Brooke R\|Wang, Panwen\|Bae, Taejeong\|Baheti, Saurabh\|Slettedahl, Seth\|Mahoney, Douglas\|Vasmatzis, Nikolaos\|Xu, Hang\|Kim, Minsoo\|Bockol, Matthew\|O'Brien, Daniel\|Grill, Diane\|Warner, Nathaniel\|Munoz-Gomez, Miguel\|Kossick, Kimberlee\|Johnson, Ruth\|Mo
PMID:	29453410

593.
Journal:	Clin Drug Investig. 2018 Jun;38(6):553-562.
Title:	First-Line Cetuximab Monotherapy in KRAS/NRAS/BRAF Mutation-Negative Colorectal Cancer Patients.
Author:	Moiseyenko, Vladimir M\|Moiseyenko, Fedor V\|Yanus, Grigoriy A\|Kuligina, Ekatherina Sh\|Sokolenko, Anna P\|Bizin, Ilya V\|Kudriavtsev, Alexey A\|Aleksakhina, Svetlana N\|Volkov, Nikita M\|Chubenko, Vyacheslav A\|Kozyreva, Kseniya S\|Kramchaninov, Mikhail M\|Zhuravle
PMID:	29470838

594.
Journal:	Bull Cancer. 2018 Apr;105(4):336-349.
Title:	Colorectal cancer cell-derived exosomes containing miR-10b regulate fibroblast cells via the PI3K/Akt pathway.
Author:	Dai, Guangyao\|Yao, Xiaoguang\|Zhang, Yubin\|Gu, Jianbin\|Geng, Yunfeng\|Xue, Fei\|Zhang, Jingcheng
PMID:	29496262

595.
Journal:	Carcinogenesis. 2018 May 3;39(5):708-718.
Title:	The molecular landscape of synchronous colorectal cancer reveals genetic heterogeneity.
Author:	Wang, Xiangfeng\|Fang, Hu\|Cheng, Yong\|Li, Lin\|Sun, Xiaohui\|Fu, Tao\|Huang, Peide\|Zhang, Anping\|Feng, Zhimin\|Li, Chunxue\|Huang, Xuanlin\|Li, Guangyan\|Du, Peina\|Yang, Huanming\|Fang, Xiaodong\|Li, Fan\|Gao, Qiang\|Liu, Baohua
PMID:	29546405

596.
Journal:	Oncol Lett. 2018 Apr;15(4):5465-5472.
Title:	Expression of factors and key components associated with the PI3K signaling pathway in colon cancer.
Author:	Chen, Hua\|Gao, Junyi\|Du, Zhenhua\|Zhang, Xuequn\|Yang, Fei\|Gao, Wei
PMID:	29552187

597.
Journal:	Theranostics. 2018 Feb 12;8(6):1678-1689.
Title:	Surface Enhanced Raman Spectroscopy (SERS) for the Multiplex Detection of Braf, Kras, and Pik3ca Mutations in Plasma of Colorectal Cancer Patients.
Author:	Li, Xiaozhou\|Yang, Tianyue\|Li, Caesar Siqi\|Song, Youtao\|Lou, Hong\|Guan, Dagang\|Jin, Lili
PMID:	29556349

598.
Journal:	Clin Cancer Res. 2018 Aug 1;24(15):3550-3559.
Title:	Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies.
Author:	Toledo, Rodrigo A\|Garralda, Elena\|Mitsi, Maria\|Pons, Tirso\|Monsech, Jorge\|Vega, Estela\|Otero, Alvaro\|Albarran, Maria I\|Banos, Natalia\|Duran, Yolanda\|Bonilla, Victoria\|Sarno, Francesca\|Camacho-Artacho, Marta\|Sanchez-Perez, Tania\|Perea, Sofia\|Alvarez, Rafae
PMID:	29588308

599.
Journal:	Anticancer Res. 2018 Apr;38(4):2235-2240.
Title:	Racial Disparities in the Molecular Landscape of Cancer.
Author:	Heath, Elisabeth I\|Lynce, Filipa\|Xiu, Joanne\|Ellerbrock, Angela\|Reddy, Sandeep K\|Obeid, Elias\|Liu, Stephen V\|Bollig-Fischer, Aliccia\|Separovic, Duska\|Vanderwalde, Ari
PMID:	29599344

600.
Journal:	Evid Based Complement Alternat Med. 2018 Feb 12;2018:6517034.
Title:	A Network Pharmacology Approach to Uncover the Multiple Mechanisms of Hedyotis diffusa Willd. on Colorectal Cancer.
Author:	Liu, Xinkui\|Wu, Jiarui\|Zhang, Dan\|Wang, Kaihuan\|Duan, Xiaojiao\|Zhang, Xiaomeng
PMID:	29619072

601.
Journal:	Oncotarget. 2018 Feb 15;9(20):15302-15311.
Title:	Differential clinicopathological and molecular features within late-onset colorectal cancer according to tumor location.
Author:	Brandariz, Lorena\|Arriba, Maria\|Garcia, Juan Luis\|Cano, Juana Maria\|Rueda, Daniel\|Rubio, Eduardo\|Rodriguez, Yolanda\|Perez, Jessica\|Vivas, Alfredo\|Sanchez, Carmen\|Tapial, Sandra\|Pena, Laura\|Garcia-Arranz, Mariano\|Garcia-Olmo, Damian\|Urioste, Miguel\|Gonzale
PMID:	29632645

602.
Journal:	Sci Rep. 2018 Apr 17;8(1):6076.
Title:	Mutation status and prognostic values of KRAS, NRAS, BRAF and PIK3CA in 353 Chinese colorectal cancer patients.
Author:	Guo, Fang\|Gong, Hai\|Zhao, Huanhuan\|Chen, Jing\|Zhang, Yiming\|Zhang, Lihua\|Shi, Xin\|Zhang, Aifeng\|Jin, Hui\|Zhang, Jianqiong\|He, Youji
PMID:	29666387

603.
Journal:	Virchows Arch. 2018 Jun;472(6):959-968.
Title:	Performance validation of an amplicon-based targeted next-generation sequencing assay and mutation profiling of 648 Chinese colorectal cancer patients.
Author:	Wang, Yajian\|Liu, Haijing\|Hou, Yingyong\|Zhou, Xiaoyan\|Liang, Li\|Zhang, Zhihong\|Shi, Huaiyin\|Xu, Sanpeng\|Hu, Peizhen\|Zheng, Zuyu\|Liu, Rui\|Tang, Tingdong\|Ye, Feng\|Liang, Zhiyong\|Bu, Hong
PMID:	29705968

604.
Journal:	J Natl Cancer Inst. 2018 Apr 27. pii: 4989438.
Title:	Molecular Landscape of ERBB2/ERBB3 Mutated Colorectal Cancer.
Author:	Loree, Jonathan M\|Bailey, Ann M\|Johnson, Amber M\|Yu, Yao\|Wu, Wenhui\|Bristow, Christopher A\|Davis, Jennifer S\|Shaw, Kenna R\|Broaddus, Russell\|Banks, Kimberly C\|Lanman, Richard B\|Meric-Bernstam, Funda\|Overman, Michael J\|Kopetz, Scott\|Raghav, Kanwal
PMID:	29718453

605.
Journal:	Oncotarget. 2018 Apr 17;9(29):20426-20438.
Title:	Hotspot KRAS exon 2 mutations in CD166 positive colorectal cancer and colorectal adenoma cells.
Author:	Wong, Hung Lai\|Ng, Lawrence Po Wah\|Koh, Su Pin\|Chan, Lawrence Wing Chi\|Wong, Evelyn Yin Kwan\|Xue, Vivian Weiwen\|Tsang, Hin Fung Andy\|Chan, Amanda Kit Ching\|Chiu, Ka Yue\|Cheuk, Wah\|Wong, Sze Chuen Cesar
PMID:	29755662

606.
Journal:	Oncotarget. 2018 Apr 17;9(29):20761-20768.
Title:	Clinical application of targeted next-generation sequencing for colorectal cancer patients: a multicentric Belgian experience.
Author:	D'Haene, Nicky\|Fontanges, Quitterie\|De Neve, Nancy\|Blanchard, Oriane\|Melendez, Barbara\|Delos, Monique\|Dehou, Marie-Francoise\|Maris, Calliope\|Nagy, Nathalie\|Rousseau, Emmanuel\|Vandenhove, Josse\|Gilles, Andre\|De Prez, Carine\|Verset, Laurine\|Van Craynest, Ma
PMID:	29755687

607.
Journal:	Cancer Med. 2018 May 17.
Title:	Primary tumor sidedness is an independent prognostic marker for survival in metastatic colorectal cancer: Results from a large retrospective cohort with mutational analysis.
Author:	Kamran, Sophia C\|Clark, Jeffrey W\|Zheng, Hui\|Borger, Darrell R\|Blaszkowsky, Lawrence S\|Allen, Jill N\|Kwak, Eunice L\|Wo, Jennifer Y\|Parikh, Aparna R\|Nipp, Ryan D\|Murphy, Janet E\|Goyal, Lipika\|Zhu, Andrew X\|Iafrate, A John\|Corcoran, Ryan B\|Ryan, David P\|Hon
PMID:	29771009

608.
Journal:	Gynecol Oncol. 2018 Jul;150(1):127-135.
Title:	Massively parallel sequencing analysis of mucinous ovarian carcinomas: genomic profiling and differential diagnoses.
Author:	Mueller, Jennifer J\|Schlappe, Brooke A\|Kumar, Rahul\|Olvera, Narciso\|Dao, Fanny\|Abu-Rustum, Nadeem\|Aghajanian, Carol\|DeLair, Deborah\|Hussein, Yaser R\|Soslow, Robert A\|Levine, Douglas A\|Weigelt, Britta
PMID:	29793804

609.
Journal:	Oncotarget. 2018 May 8;9(35):23960-23974.
Title:	Identification of different mutational profiles in cancers arising in specific colon segments by next generation sequencing.
Author:	Oliveira, Duarte Mendes\|Laudanna, Carmelo\|Migliozzi, Simona\|Zoppoli, Pietro\|Santamaria, Gianluca\|Grillone, Katia\|Elia, Laura\|Mignogna, Chiara\|Biamonte, Flavia\|Sacco, Rosario\|Corcione, Francesco\|Viglietto, Giuseppe\|Malanga, Donatella\|Rizzuto, Antonia
PMID:	29844865

610.
Journal:	Oncotarget. 2018 Apr 27;9(32):22749-22768.
Title:	Simultaneous identification of clinically relevant single nucleotide variants, copy number alterations and gene fusions in solid tumors by targeted next-generation sequencing.
Author:	Oliveira, Duarte Mendes\|Mirante, Teresa\|Mignogna, Chiara\|Scrima, Marianna\|Migliozzi, Simona\|Rocco, Gaetano\|Franco, Renato\|Corcione, Francesco\|Viglietto, Giuseppe\|Malanga, Donatella\|Rizzuto, Antonia
PMID:	29854313

611.
Journal:	Oncoimmunology. 2018 Mar 19;7(7):e1442999.
Title:	TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor CD274 (PD-L1) expression status and tumor-infiltrating lymphocytes in colorectal carcinomas.
Author:	Hamada, Tsuyoshi\|Soong, Thing Rinda\|Masugi, Yohei\|Kosumi, Keisuke\|Nowak, Jonathan A\|da Silva, Annacarolina\|Mu, Xinmeng Jasmine\|Twombly, Tyler S\|Koh, Hideo\|Yang, Juhong\|Song, Mingyang\|Liu, Li\|Gu, Mancang\|Shi, Yan\|Nosho, Katsuhiko\|Morikawa, Teppei\|Inamura,
PMID:	29900052

612.
Journal:	Cancer Sci. 2018 Aug;109(8):2567-2575.
Title:	Phase II trial of biweekly cetuximab and irinotecan as third-line therapy for pretreated KRAS exon 2 wild-type colorectal cancer.
Author:	Osumi, Hiroki\|Shinozaki, Eiji\|Mashima, Tetsuo\|Wakatsuki, Takeru\|Suenaga, Mitsukuni\|Ichimura, Takashi\|Ogura, Mariko\|Ota, Yumiko\|Nakayama, Izuma\|Takahari, Daisuke\|Chin, Keisho\|Miki, Yoshio\|Yamaguchi, Kensei
PMID:	29908105

613.
Journal:	Biosci Rep. 2018 Jul 31;38(4). pii: BSR20180322.
Title:	Circulating tumor DNA detectable in early- and late-stage colorectal cancer patients.
Author:	Yang, Ying-Chi\|Wang, Dong\|Jin, Lan\|Yao, Hong-Wei\|Zhang, Jing-Hui\|Wang, Jin\|Zhao, Xiao-Mu\|Shen, Chun-Ying\|Chen, Wei\|Wang, Xue-Liang\|Shi, Rong\|Chen, Si-Yi\|Zhang, Zhong-Tao
PMID:	29914973

614.
Journal:	Surg Oncol. 2018 Jun;27(2):280-288.
Title:	Clinical significance and prognostic relevance of KRAS, BRAF, PI3K and TP53 genetic mutation analysis for resectable and unresectable colorectal liver metastases: A systematic review of the current evidence.
Author:	Tsilimigras, Diamantis I\|Ntanasis-Stathopoulos, Ioannis\|Bagante, Fabio\|Moris, Demetrios\|Cloyd, Jordan\|Spartalis, Eleftherios\|Pawlik, Timothy M
PMID:	29937183

615.
Journal:	Oncotarget. 2018 Jun 8;9(44):27412-27422.
Title:	The landscape of somatic mutation in sporadic Chinese colorectal cancer.
Author:	Liu, Zhe\|Yang, Chao\|Li, Xiangchun\|Luo, Wen\|Roy, Bhaskar\|Xiong, Teng\|Zhang, Xiuqing\|Yang, Huanming\|Wang, Jian\|Ye, Zhenhao\|Chen, Yang\|Song, Jinghe\|Ma, Shuai\|Zhou, Yong\|Yang, Min\|Fang, Xiaodong\|Du, Jie
PMID:	29937994

616.
Journal:	J Exp Clin Cancer Res. 2018 Jun 26;37(1):124.
Title:	Liquid biopsy in mice bearing colorectal carcinoma xenografts: gateways regulating the levels of circulating tumor DNA (ctDNA) and miRNA (ctmiRNA).
Author:	Gasparello, Jessica\|Allegretti, Matteo\|Tremante, Elisa\|Fabbri, Enrica\|Amoreo, Carla Azzurra\|Romania, Paolo\|Melucci, Elisa\|Messana, Katia\|Borgatti, Monica\|Giacomini, Patrizio\|Gambari, Roberto\|Finotti, Alessia
PMID:	29941002

617.
Journal:	BMC Cancer. 2018 Jun 27;18(1):695.
Title:	Gene promoter and exon DNA methylation changes in colon cancer development - mRNA expression and tumor mutation alterations.
Author:	Molnar, Bela\|Galamb, Orsolya\|Peterfia, Balint\|Wichmann, Barnabas\|Csabai, Istvan\|Bodor, Andras\|Kalmar, Alexandra\|Szigeti, Krisztina Andrea\|Bartak, Barbara Kinga\|Nagy, Zsofia Brigitta\|Valcz, Gabor\|Patai, Arpad V\|Igaz, Peter\|Tulassay, Zsolt
PMID:	29945573

618.
Journal:	Cell Death Dis. 2018 Jul 3;9(7):739.
Title:	PIK3CA mutations confer resistance to first-line chemotherapy in colorectal cancer.
Author:	Wang, Qiang\|Shi, Yan-Long\|Zhou, Kai\|Wang, Li-Li\|Yan, Ze-Xuan\|Liu, Yu-Lin\|Xu, Li-Li\|Zhao, Shi-Wei\|Chu, Hui-Li\|Shi, Ting-Ting\|Ma, Qing-Hua\|Bi, Jingwang
PMID:	29970892

619.
Journal:	World J Surg Oncol. 2018 Jul 5;16(1):128.
Title:	Differences in gene mutations according to gender among patients with colorectal cancer.
Author:	Tsai, Yi-Jian\|Huang, Sheng-Chieh\|Lin, Hung-Hsin\|Lin, Chun-Chi\|Lan, Yuan-Tzu\|Wang, Huann-Sheng\|Yang, Shung-Haur\|Jiang, Jeng-Kai\|Chen, Wei-Shone\|Lin, Tzu-Chen\|Lin, Jen-Kou\|Chang, Shih-Ching
PMID:	29976257

620.
Journal:	Int J Cancer. 2018 Jul 6.
Title:	Activation of WNT/beta-catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboring PIK3CA mutations.
Author:	Park, Ye-Lim\|Kim, Hwang-Phill\|Cho, Young-Won\|Min, Dong-Wook\|Cheon, Seul-Ki\|Lim, Yoo Joo\|Song, Sang-Hyun\|Jin Kim, Sung\|Han, Sae-Won\|Park, Kyu Joo\|Kim, Tae-You
PMID:	29978469

621.
Journal:	PLoS One. 2018 Jul 12;13(7):e0200163.
Title:	Downregulation of PIK3CA via antibody-esiRNA-complexes suppresses human xenograft tumor growth.
Author:	Baumer, Nicole\|Rehkamper, Jan\|Appel, Neele\|Terheyden, Lisa\|Hartmann, Wolfgang\|Wardelmann, Eva\|Buchholz, Frank\|Muller-Tidow, Carsten\|Berdel, Wolfgang E\|Baumer, Sebastian
PMID:	30001368

622.
Journal:	Dev Reprod. 2018 Jun;22(2):133-142.
Title:	Combination of BEZ235 and Metformin Has Synergistic Effect on Cell Viability in Colorectal Cancer Cells.
Author:	Kim, Taewan\|Kim, Taehyung\|Choi, Soonyoung\|Ko, Hyeran\|Park, Deokbae\|Lee, Youngki
PMID:	30023463

623.
Journal:	BMC Cancer. 2018 Jul 20;18(1):752.
Title:	Genomic alterations accompanying tumour evolution in colorectal cancer: tracking the differences between primary tumours and synchronous liver metastases by whole-exome sequencing.
Author:	Mogensen, M B\|Rossing, M\|Ostrup, O\|Larsen, P N\|Heiberg Engel, P J\|Jorgensen, L N\|Hogdall, E V\|Eriksen, J\|Ibsen, P\|Jess, P\|Grauslund, M\|Nielsen, H J\|Nielsen, F C\|Vainer, B\|Osterlind, K
PMID:	30029640

624.
Journal:	ACS Med Chem Lett. 2018 Jun 25;9(7):719-724.
Title:	Discovery of an Orally Bioavailable Dual PI3K/mTOR Inhibitor Based on Sulfonyl-Substituted Morpholinopyrimidines.
Author:	Shen, Sida\|He, Xiangyu\|Yang, Zheng\|Zhang, Liang\|Liu, Yingtao\|Zhang, Zhiyuan\|Wang, Weiwei\|Liu, Wei\|Li, Yufeng\|Huang, Dong\|Sun, Kai\|Ni, Xiaojing\|Yang, Xu\|Chu, Xinxin\|Cui, Yumin\|Lv, Qiang\|Lan, Jiong\|Zhou, Fusheng
PMID:	30034607

625.
Journal:	Ann Saudi Med. 2018 Jul-Aug;38(4):251-259.
Title:	Molecular characteristics of colorectal cancer in a Middle Eastern population in a single institution.
Author:	Ibrahim, Tony\|Saer-Ghorra, Claude\|Trak-Smayra, Vivane\|Nadiri, Samah\|Yazbeck, Charbel\|Baz, Maria\|Kattan, Joseph G
PMID:	30078023

626.
Journal:	Adv Clin Exp Med. 2018 Aug 7.
Title:	Analysis of KRAS, NRAS, BRAF, and PIK3CA mutations could predict metastases in colorectal cancer: A preliminary study.
Author:	Wojas-Krawczyk, Kamila\|Kalinka-Warzocha, Ewa\|Reszka, Katarzyna\|Nicos, Marcin\|Szumilo, Justyna\|Mandziuk, Slawomir\|Szczepaniak, Katarzyna\|Kupnicka, Dorota\|Lewandowski, Remigiusz\|Milanowski, Janusz\|Krawczyk, Pawel
PMID:	30085422

627.
Journal:	Gastroenterology Res. 2018 Aug;11(4):264-273.
Title:	Difference Between Left-Sided and Right-Sided Colorectal Cancer: A Focused Review of Literature.
Author:	Baran, Burcin\|Mert Ozupek, Nazli\|Yerli Tetik, Nihal\|Acar, Emine\|Bekcioglu, Omer\|Baskin, Yasemin
PMID:	30116425

628.
Journal:	J Cancer Res Clin Oncol. 2018 Aug 31. pii: 10.1007/s00432-018-2742-1.
Title:	The gene mutational discrepancies between primary and paired metastatic colorectal carcinoma detected by next-generation sequencing.
Author:	Zou, Shuang-Mei\|Li, Wei-Hua\|Wang, Wen-Miao\|Li, Wen-Bin\|Shi, Su-Sheng\|Ying, Jian-Ming\|Lyu, Ning
PMID:	30171333

629.
Journal:	Cancer Cell Int. 2018 Sep 6;18:131.
Title:	Assessment of intratumor immune-microenvironment in colorectal cancers with extranodal extension of nodal metastases.
Author:	Fassan, Matteo\|Vianello, Luca\|Sacchi, Diana\|Fanelli, Giuseppe N\|Munari, Giada\|Scarpa, Marco\|Cappellesso, Rocco\|Loupakis, Fotios\|Lanza, Cristiano\|Salmaso, Roberta\|Mescoli, Claudia\|Valeri, Nicola\|Agostini, Marco\|D'Angelo, Edoardo\|Lonardi, Sara\|Pucciarelli,
PMID:	30202242

630.
Journal:	Eur J Cancer. 2018 Sep 12;103:98-107.
Title:	Vitamin D status after colorectal cancer diagnosis and patient survival according to immune response to tumour.
Author:	Hamada, Tsuyoshi\|Liu, Li\|Nowak, Jonathan A\|Mima, Kosuke\|Cao, Yin\|Ng, Kimmie\|Twombly, Tyler S\|Song, Mingyang\|Jung, Seungyoun\|Dou, Ruoxu\|Masugi, Yohei\|Kosumi, Keisuke\|Shi, Yan\|da Silva, Annacarolina\|Gu, Mancang\|Li, Wanwan\|Keum, NaNa\|Wu, Kana\|Nosho, Katsuhik
PMID:	30219720

631.
Journal:	Am Soc Clin Oncol Educ Book. 2018 May 23;(38):978-997.
Title:	Liquid Biopsy to Identify Actionable Genomic Alterations.
Author:	Ou, Sai-Hong Ignatius\|Nagasaka, Misako\|Zhu, Viola W
PMID:	30231331

632.
Journal:	Am J Pathol. 2018 Sep 19. pii: S0002-9440(18)30364-X.
Title:	The Amount of Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Clinical Outcome.
Author:	Kosumi, Keisuke\|Hamada, Tsuyoshi\|Koh, Hideo\|Borowsky, Jennifer\|Bullman, Susan\|Twombly, Tyler S\|Nevo, Daniel\|Masugi, Yohei\|Liu, Li\|da Silva, Annacarolina\|Chen, Yang\|Du, Chunxia\|Gu, Mancang\|Li, Chenxi\|Li, Wanwan\|Liu, Hongli\|Shi, Yan\|Mima, Kosuke\|Song, Mingy
PMID:	30243655

633.
Journal:	J Clin Pathol. 2018 Oct 25. pii: jclinpath-2018-205483.
Title:	Positive association of PIK3CA mutation with KRAS mutation but not BRAF mutation in colorectal cancer suggests co-selection is gene specific but not pathway specific.
Author:	Susanti, Susanti\|Fadhil, Wakkas\|Murtaza, Shamayal\|Hassall, James C\|Ebili, Henry O\|Oniscu, Anca\|Ilyas, Mohammad
PMID:	30361395