Primary Site >> Biliary tract Cancer
Gene >> PIK3CA
| 1. | |||||||||||
| Journal: | Genes Chromosomes Cancer. 2008 May;47(5):363-7. | ||||||||||
| Title: | Rare PIK3CA hotspot mutations in carcinomas of the biliary tract. | ||||||||||
| Author: | Riener, Marc-Oliver|Bawohl, Marion|Clavien, Pierre-Alain|Jochum, Wolfram | ||||||||||
| PMID: | 18181165 | ||||||||||
| 2. | |||||||||||
| Journal: | J Gastrointest Surg. 2009 Aug;13(8):1510-6. | ||||||||||
| Title: | Molecular analysis of PIK3CA, BRAF, and RAS oncogenes in periampullary and ampullary adenomas and carcinomas. | ||||||||||
| Author: | Schonleben, Frank|Qiu, Wanglong|Allendorf, John D|Chabot, John A|Remotti, Helen E|Su, Gloria H | ||||||||||
| PMID: | 19440799 | ||||||||||
| 3. | |||||||||||
| Journal: | Biomed Pharmacother. 2011 Feb;65(1):22-6. | ||||||||||
| Title: | KRAS and PIK3CA but not BRAF genes are frequently mutated in Chinese cholangiocarcinoma patients. | ||||||||||
| Author: | Xu, Rui Feng|Sun, Ji Ping|Zhang, Shi Rong|Zhu, Guan Shan|Li, Li Bo|Liao, Yu Lin|Xie, Jian Ming|Liao, Wang Jun | ||||||||||
| PMID: | 21051183 | ||||||||||
| 4. | |||||||||||
| Journal: | BMC Cancer. 2011 Feb 8;11:60. | ||||||||||
| Title: | Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma. | ||||||||||
| Author: | Deshpande, Vikram|Nduaguba, Afamefuna|Zimmerman, Stephanie M|Kehoe, Sarah M|Macconaill, Laura E|Lauwers, Gregory Y|Ferrone, Cristina|Bardeesy, Nabeel|Zhu, Andrew X|Hezel, Aram F | ||||||||||
| PMID: | 21303542 | ||||||||||
| 5. | |||||||||||
| Journal: | Semin Liver Dis. 2011 May;31(2):173-87. | ||||||||||
| Title: | Genetics of hepatobiliary carcinogenesis. | ||||||||||
| Author: | Nault, Jean-Charles|Zucman-Rossi, Jessica | ||||||||||
| PMID: | 21538283 | ||||||||||
| 6. | |||||||||||
| Journal: | Oncologist. 2012;17(1):72-9. | ||||||||||
| Title: | Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. | ||||||||||
| Author: | Borger, Darrell R|Tanabe, Kenneth K|Fan, Kenneth C|Lopez, Hector U|Fantin, Valeria R|Straley, Kimberly S|Schenkein, David P|Hezel, Aram F|Ancukiewicz, Marek|Liebman, Hannah M|Kwak, Eunice L|Clark, Jeffrey W|Ryan, David P|Deshpande, Vikram|Dias-Santagata, | ||||||||||
| PMID: | 22180306 | ||||||||||
| 7. | |||||||||||
| Journal: | Hum Pathol. 2013 Jul;44(7):1216-22. | ||||||||||
| Title: | Molecular profiling of cholangiocarcinoma shows potential for targeted therapy treatment decisions. | ||||||||||
| Author: | Voss, Jesse S|Holtegaard, Leonard M|Kerr, Sarah E|Fritcher, Emily G Barr|Roberts, Lewis R|Gores, Gregory J|Zhang, Jun|Highsmith, W Edward|Halling, Kevin C|Kipp, Benjamin R | ||||||||||
| PMID: | 23391413 | ||||||||||
| 8. | |||||||||||
| Journal: | Tumour Biol. 2013 Dec;34(6):3637-48. | ||||||||||
| Title: | Increased activation of PI3K/AKT signaling pathway is associated with cholangiocarcinoma metastasis and PI3K/mTOR inhibition presents a possible therapeutic strategy. | ||||||||||
| Author: | Yothaisong, Supak|Dokduang, Hasaya|Techasen, Anchalee|Namwat, Nisana|Yongvanit, Puangrat|Bhudhisawasdi, Vajarabhongsa|Puapairoj, Anucha|Riggins, Gregory J|Loilome, Watcharin | ||||||||||
| PMID: | 23832540 | ||||||||||
| 9. | |||||||||||
| Journal: | Hum Pathol. 2014 Apr;45(4):701-8. | ||||||||||
| Title: | Molecular characterization of gallbladder cancer using somatic mutation profiling. | ||||||||||
| Author: | Javle, Milind|Rashid, Asif|Churi, Chaitanya|Kar, Siddhartha|Zuo, Mingxin|Eterovic, Agda Karina|Nogueras-Gonzalez, Graciela M|Janku, Filip|Shroff, Rachna T|Aloia, Thomas A|Vauthey, Jean-Nicholas|Curley, Steven|Mills, Gordon|Roa, Ivan | ||||||||||
| PMID: | 24508317 | ||||||||||
| 10. | |||||||||||
| Journal: | Ann Surg Oncol. 2014 Nov;21(12):3827-34. | ||||||||||
| Title: | Genomic profiling of intrahepatic cholangiocarcinoma: refining prognosis and identifying therapeutic targets. | ||||||||||
| Author: | Zhu, Andrew X|Borger, Darrell R|Kim, Yuhree|Cosgrove, David|Ejaz, Aslam|Alexandrescu, Sorin|Groeschl, Ryan Thomas|Deshpande, Vikram|Lindberg, James M|Ferrone, Cristina|Sempoux, Christine|Yau, Thomas|Poon, Ronnie|Popescu, Irinel|Bauer, Todd W|Gamblin, T Cl | ||||||||||
| PMID: | 24889489 | ||||||||||
| 11. | |||||||||||
| Journal: | Indian J Pathol Microbiol. 2014 Jan-Mar;57(1):9-12. | ||||||||||
| Title: | Mutation profiling in gallbladder cancer in Indian population. | ||||||||||
| Author: | Kumari, Niraj|Corless, Christopher L|Warrick, Andrea|Beadling, Carol|Nelson, Dylan|Neff, Tanay|Krishnani, Narendra|Kapoor, Vinay Kumar | ||||||||||
| PMID: | 24739824 | ||||||||||
| 12. | |||||||||||
| Journal: | Oncologist. 2014 Mar;19(3):235-42. | ||||||||||
| Title: | New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing. | ||||||||||
| Author: | Ross, Jeffrey S|Wang, Kai|Gay, Laurie|Al-Rohil, Rami|Rand, Janne V|Jones, David M|Lee, Hwa J|Sheehan, Christine E|Otto, Geoff A|Palmer, Gary|Yelensky, Roman|Lipson, Doron|Morosini, Deborah|Hawryluk, Matthew|Catenacci, Daniel V T|Miller, Vincent A|Churi, C | ||||||||||
| PMID: | 24563076 | ||||||||||
| 13. | |||||||||||
| Journal: | Mod Pathol. 2014 May;27(5):665-74. | ||||||||||
| Title: | Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels. | ||||||||||
| Author: | Mikhitarian, Kaidi|Pollen, Maressa|Zhao, Zhiguo|Shyr, Yu|Merchant, Nipun B|Parikh, Alexander|Revetta, Frank|Washington, M Kay|Vnencak-Jones, Cindy|Shi, Chanjuan | ||||||||||
| PMID: | 24186143 | ||||||||||
| 14. | |||||||||||
| Journal: | Mod Pathol. 2014 May;27(5):731-9. | ||||||||||
| Title: | High throughput molecular profiling reveals differential mutation patterns in intrahepatic cholangiocarcinomas arising in chronic advanced liver diseases. | ||||||||||
| Author: | Jang, Sejin|Chun, Sung-Min|Hong, Seoung-Mo|Sung, Chang Ohk|Park, Hosub|Kang, Hyo Jeong|Kim, Kyu-pyo|Lee, Young Joo|Yu, Eunsil | ||||||||||
| PMID: | 24186137 | ||||||||||
| 15. | |||||||||||
| Journal: | Transl Oncol. 2015 Feb;8(1):40-6. | ||||||||||
| Title: | Molecular Subgroup Analysis of Clinical Outcomes in a Phase 3 Study of Gemcitabine and Oxaliplatin with or without Erlotinib in Advanced Biliary Tract Cancer. | ||||||||||
| Author: | Kim, Seung Tae|Jang, Kee-Taek|Lee, Jeeyun|Jang, Heung-Moon|Choi, Hye-Jin|Jang, Hye-Lim|Park, Se Hoon|Park, Young Suk|Lim, Ho Yeong|Kang, Won Ki|Park, Joon Oh | ||||||||||
| PMID: | 25749176 | ||||||||||
| 16. | |||||||||||
| Journal: | Mod Pathol. 2015 Sep;28(9):1249-64. | ||||||||||
| Title: | Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases. | ||||||||||
| Author: | Schlitter, Anna Melissa|Jang, Kee-Taek|Kloppel, Gunter|Saka, Burcu|Hong, Seung-Mo|Choi, Hyejeong|Offerhaus, George Johan|Hruban, Ralph H|Zen, Yoh|Konukiewitz, Bjorn|Regel, Ivonne|Allgauer, Michael|Balci, Serdar|Basturk, Olca|Reid, Michelle D|Esposito, Ire | ||||||||||
| PMID: | 26111977 | ||||||||||
| 17. | |||||||||||
| Journal: | Oncotarget. 2015 Nov 24;6(37):40026-35. | ||||||||||
| Title: | PIK3CA mutation detection in metastatic biliary cancer using cell-free DNA. | ||||||||||
| Author: | Kim, Seung Tae|Lira, Maruja|Deng, Shibing|Lee, Sujin|Park, Young Suk|Lim, Ho Yeong|Kang, Won Ki|Mao, Mao|Heo, Jin Seok|Kwon, Wooil|Jang, Kee-Taek|Lee, Jeeyun|Park, Joon Oh | ||||||||||
| PMID: | 26498688 | ||||||||||
| 18. | |||||||||||
| Journal: | Cancer Metastasis Rev. 2016 Jun;35(2):263-75. | ||||||||||
| Title: | Genomics of gallbladder cancer: the case for biomarker-driven clinical trial design. | ||||||||||
| Author: | Sicklick, Jason K|Fanta, Paul T|Shimabukuro, Kelly|Kurzrock, Razelle | ||||||||||
| PMID: | 26857926 | ||||||||||
| 19. | |||||||||||
| Journal: | Jpn Clin Med. 2016 Dec 13;7:33-39. | ||||||||||
| Title: | KRAS Mutation as a Potential Prognostic Biomarker of Biliary Tract Cancers. | ||||||||||
| Author: | Yokoyama, Masaaki|Ohnishi, Hiroaki|Ohtsuka, Kouki|Matsushima, Satsuki|Ohkura, Yasuo|Furuse, Junji|Watanabe, Takashi|Mori, Toshiyuki|Sugiyama, Masanori | ||||||||||
| PMID: | 28008299 | ||||||||||
| 20. | |||||||||||
| Journal: | Crit Rev Oncol Hematol. 2016 Nov;107:111-118. | ||||||||||
| Title: | Molecular characteristics of biliary tract cancer. | ||||||||||
| Author: | Sohal, Davendra P S|Shrotriya, Shiva|Abazeed, Mohamed|Cruise, Michael|Khorana, Alok | ||||||||||
| PMID: | 27823638 | ||||||||||
| 21. | |||||||||||
| Journal: | J Exp Clin Cancer Res. 2016 Jun 18;35(1):97. | ||||||||||
| Title: | The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR. | ||||||||||
| Author: | Zhao, Shuai|Cao, Yang|Liu, Shi-Bo|Wang, Xu-An|Bao, Run-Fa|Shu, Yi-Jun|Hu, Yun-Ping|Zhang, Yi-Jian|Jiang, Lin|Zhang, Fei|Liang, Hai-Bin|Li, Huai-Feng|Ma, Qiang|Xu, Yi|Wang, Zheng|Zhang, Yi-Chi|Chen, Lei|Zhou, Jian|Liu, Ying-Bin | ||||||||||
| PMID: | 27317099 | ||||||||||
| 22. | |||||||||||
| Journal: | Transl Oncol. 2016 Jun;9(3):173-8. | ||||||||||
| Title: | Genomic Alterations in Biliary Tract Cancer Using Targeted Sequencing. | ||||||||||
| Author: | Yoo, Kwai Han|Kim, Nayoung K D|Kwon, Woo Il|Lee, Chung|Kim, Sun Young|Jang, Jiryeon|Ahn, Jungmi|Kang, Mihyun|Jang, Hyojin|Kim, Seung Tae|Ahn, Soomin|Jang, Kee-Taek|Park, Young Suk|Park, Woong-Yang|Lee, Jeeyun|Heo, Jin Seok|Park, Joon Oh | ||||||||||
| PMID: | 27267833 | ||||||||||
| 23. | |||||||||||
| Journal: | Pathology. 2016 Jan;48(1):35-40. | ||||||||||
| Title: | EGFR, COX2, p-AKT expression and PIK3CA mutation in distal extrahepatic bile duct carcinoma. | ||||||||||
| Author: | Moon, Ahrim|Chin, Susie|Kim, Hee Kyung|Kwak, Jeong Ja|Koh, Eun Suk|Kim, Youn Wha|Jang, Kee-Taek | ||||||||||
| PMID: | 27020207 | ||||||||||
| 24. | |||||||||||
| Journal: | Ann Surg Oncol. 2016 May;23(5):1699-707. | ||||||||||
| Title: | Cholangiocarcinoma Heterogeneity Revealed by Multigene Mutational Profiling: Clinical and Prognostic Relevance in Surgically Resected Patients. | ||||||||||
| Author: | Ruzzenente, Andrea|Fassan, Matteo|Conci, Simone|Simbolo, Michele|Lawlor, Rita T|Pedrazzani, Corrado|Capelli, Paola|D'Onofrio, Mirko|Iacono, Calogero|Scarpa, Aldo|Guglielmi, Alfredo | ||||||||||
| PMID: | 26717940 | ||||||||||
| 25. | |||||||||||
| Journal: | Oncotarget. 2017 Jan 17;8(3):5349-5360. | ||||||||||
| Title: | Guidance to rational use of pharmaceuticals in gallbladder sarcomatoid carcinoma using patient-derived cancer cells and whole exome sequencing. | ||||||||||
| Author: | Feng, Feiling|Cheng, Qingbao|Yang, Liang|Zhang, Dadong|Ji, Shunlong|Zhang, Qiangzu|Lin, Yihui|Li, Fugen|Xiong, Lei|Liu, Chen|Jiang, Xiaoqing | ||||||||||
| PMID: | 28029662 | ||||||||||
| 26. | |||||||||||
| Journal: | Mol Oncol. 2017 Sep;11(9):1130-1142. | ||||||||||
| Title: | K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines. | ||||||||||
| Author: | Yeung, Yvonne|Lau, David K|Chionh, Fiona|Tran, Hoanh|Tse, Janson W T|Weickhardt, Andrew J|Nikfarjam, Mehrdad|Scott, Andrew M|Tebbutt, Niall C|Mariadason, John M | ||||||||||
| PMID: | 28544747 | ||||||||||
| 27. | |||||||||||
| Journal: | Oncol Lett. 2017 Jul;14(1):877-884. | ||||||||||
| Title: | Genetic alterations in Japanese extrahepatic biliary tract cancer. | ||||||||||
| Author: | Noguchi, Rei|Yamaguchi, Kiyoshi|Ikenoue, Tsuneo|Terakado, Yumi|Ohta, Yasunori|Yamashita, Naohide|Kainuma, Osamu|Yokoi, Sana|Maru, Yoshiaki|Nagase, Hiroki|Furukawa, Yoichi | ||||||||||
| PMID: | 28693246 | ||||||||||
| 28. | |||||||||||
| Journal: | World J Gastroenterol. 2017 Jun 21;23(23):4311-4316. | ||||||||||
| Title: | Benefit of everolimus in treatment of an intrahepatic cholangiocarcinoma patient with a PIK3CA mutation. | ||||||||||
| Author: | Bian, Ji-Lai|Wang, Mei-Mei|Tong, En-Juan|Sun, Jing|Li, Ming|Miao, Zhi-Bo|Li, Yan-Lin|Zhu, Bai-Hong|Xu, Jia-Jia | ||||||||||
| PMID: | 28694672 | ||||||||||
| 29. | |||||||||||
| Journal: | Pathol Res Pract. 2017 Aug;213(8):1010-1013. | ||||||||||
| Title: | Adenosquamous gallbladder carcinoma: Multigene hotspot mutational profiling reveals a monoclonal origin of the two components. | ||||||||||
| Author: | Galuppini, Francesca|Salmaso, Roberta|Valentini, Elisa|Lanza, Cristiano|Maretto, Isacco|Nitti, Donato|Rugge, Massimo|Fassan, Matteo | ||||||||||
| PMID: | 28698100 | ||||||||||
| 30. | |||||||||||
| Journal: | Ecancermedicalscience. 2017 Aug 7;11:757. | ||||||||||
| Title: | Mutational frequency of KRAS, NRAS, IDH2, PIK3CA, and EGFR in North Indian gallbladder cancer patients. | ||||||||||
| Author: | Sharma, Aarti|Kumar, Ashok|Kumari, Niraj|Krishnani, Narendra|Rastogi, Neeraj | ||||||||||
| PMID: | 28900470 | ||||||||||
| 31. | |||||||||||
| Journal: | Cancer Lett. 2017 Dec 28;411:162-170. | ||||||||||
| Title: | Anti-tumor effects of NVP-BKM120 alone or in combination with MEK162 in biliary tract cancer. | ||||||||||
| Author: | Jin, Ling|Jin, Mei-Hua|Nam, Ah-Rong|Park, Ji-Eun|Bang, Ju-Hee|Oh, Do-Youn|Bang, Yung-Jue | ||||||||||
| PMID: | 29024814 | ||||||||||
| 32. | |||||||||||
| Journal: | Clin Oncol (R Coll Radiol). 2018 Mar;30(3):185-191. | ||||||||||
| Title: | Clinical Outcome of Patients with Advanced Biliary Tract Cancer in a Dedicated Phase I Unit. | ||||||||||
| Author: | Sundar, R|Custodio, A|Petruckevich, A|Chenard-Poirier, M|Ameratunga, M|Collins, D|Lim, J|Kaye, S B|Tunariu, N|Banerji, U|de Bono, J|Lopez, J | ||||||||||
| PMID: | 29224898 | ||||||||||
| 33. | |||||||||||
| Journal: | Br J Cancer. 2018 Feb 20;118(4):462-470. | ||||||||||
| Title: | Phase I dose-escalation study of copanlisib in combination with gemcitabine or cisplatin plus gemcitabine in patients with advanced cancer. | ||||||||||
| Author: | Kim, R D|Alberts, S R|Pena, C|Genvresse, I|Ajavon-Hartmann, A|Xia, C|Kelly, A|Grilley-Olson, J E | ||||||||||
| PMID: | 29348486 | ||||||||||
| 34. | |||||||||||
| Journal: | Am J Cancer Res. 2018 Jan 1;8(1):2-15. eCollection 2018. | ||||||||||
| Title: | Genotyping and mRNA profiling reveal actionable molecular targets in biliary tract cancers. | ||||||||||
| Author: | Papadopoulou, Kyriaki|Murray, Samuel|Manousou, Kyriaki|Tikas, Ioannis|Dervenis, Christos|Sgouros, Joseph|Rontogianni, Dimitra|Lakis, Sotirios|Bobos, Mattheos|Poulios, Christos|Pervana, Stavroula|Lazaridis, Georgios|Fountzilas, George|Kotoula, Vassiliki | ||||||||||
| PMID: | 29416916 | ||||||||||
| 35. | |||||||||||
| Journal: | Br J Cancer. 2018 Apr;118(7):966-971. | ||||||||||
| Title: | Phase II study of everolimus (RAD001) monotherapy as first-line treatment in advanced biliary tract cancer with biomarker exploration: the RADiChol Study. | ||||||||||
| Author: | Lau, David K|Tay, Rebecca Y|Yeung, Yvonne H|Chionh, Fiona|Mooi, Jennifer|Murone, Carmel|Skrinos, Effie|Price, Timothy J|Mariadason, John M|Tebbutt, Niall C | ||||||||||
| PMID: | 29527009 | ||||||||||
| 36. | |||||||||||
| Journal: | J Gastrointest Oncol. 2018 Feb;9(1):111-125. | ||||||||||
| Title: | Investigation of targetable predictive and prognostic markers in gallbladder carcinoma. | ||||||||||
| Author: | Neyaz, Azfar|Husain, Nuzhat|Gupta, Sameer|Kumari, Swati|Arora, Aditi|Awasthi, Namrata Puneet|Malhotra, Kiran Preet|Misra, Sanjeev | ||||||||||
| PMID: | 29564177 | ||||||||||
| 37. | |||||||||||
| Journal: | Jpn J Clin Oncol. 2018 Aug 1;48(8):703-711. | ||||||||||
| Title: | New developments in systemic therapy for advanced biliary tract cancer. | ||||||||||
| Author: | Morizane, Chigusa|Ueno, Makoto|Ikeda, Masafumi|Okusaka, Takuji|Ishii, Hiroshi|Furuse, Junji | ||||||||||
| PMID: | 29893894 | ||||||||||