Primary Site >> Pancreatic Cancer
Gene >> PDGFRB
| 1. | |||||||||||
| Journal: | Int J Cancer. 1995 Sep 4;62(5):529-35. | ||||||||||
| Title: | Induction of platelet-derived growth factor A and B chains and over-expression of their receptors in human pancreatic cancer. | ||||||||||
| Author: | Ebert, M|Yokoyama, M|Friess, H|Kobrin, M S|Buchler, M W|Korc, M | ||||||||||
| PMID: | 7665222 | ||||||||||
| 2. | |||||||||||
| Journal: | Clin Cancer Res. 2003 Dec 15;9(17):6534-44. | ||||||||||
| Title: | Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model. | ||||||||||
| Author: | Hwang, Rosa F|Yokoi, Kenji|Bucana, Corazon D|Tsan, Rachel|Killion, Jerald J|Evans, Douglas B|Fidler, Isaiah J | ||||||||||
| PMID: | 14695158 | ||||||||||
| 3. | |||||||||||
| Journal: | Cancer Res. 2005 Nov 15;65(22):10371-80. | ||||||||||
| Title: | Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model. | ||||||||||
| Author: | Yokoi, Kenji|Sasaki, Takamitsu|Bucana, Corazon D|Fan, Dominic|Baker, Cheryl H|Kitadai, Yasuhiko|Kuwai, Toshio|Abbruzzese, James L|Fidler, Isaiah J | ||||||||||
| PMID: | 16288027 | ||||||||||
| 4. | |||||||||||
| Journal: | Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):678-89. | ||||||||||
| Title: | Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668. | ||||||||||
| Author: | Davis, Darren W|Takamori, Ryan|Raut, Chandrajit P|Xiong, Henry Q|Herbst, Roy S|Stadler, Walter M|Heymach, John V|Demetri, George D|Rashid, Asif|Shen, Yu|Wen, Sijin|Abbruzzese, James L|McConkey, David J | ||||||||||
| PMID: | 15701856 | ||||||||||
| 5. | |||||||||||
| Journal: | Cancer Lett. 2006 Feb 28;233(2):328-37. | ||||||||||
| Title: | The tyrosine kinase inhibitor imatinib fails to inhibit pancreatic cancer progression. | ||||||||||
| Author: | Chen, Jie|Rocken, Christoph|Nitsche, Barbara|Hosius, Christian|Gschaidmeier, Harald|Kahl, Stefan|Malfertheiner, Peter|Ebert, Matthias P A | ||||||||||
| PMID: | 15893416 | ||||||||||
| 6. | |||||||||||
| Journal: | Drug Resist Updat. 2006 Feb-Apr;9(1-2):1-18. Epub 2006 Apr 18. | ||||||||||
| Title: | Tyrosine kinase inhibitors and gemcitabine: new treatment options in pancreatic cancer? | ||||||||||
| Author: | Kleespies, Axel|Jauch, Karl-Walter|Bruns, Christiane J | ||||||||||
| PMID: | 16621676 | ||||||||||
| 7. | |||||||||||
| Journal: | Int J Oncol. 2006 Jul;29(1):125-38. | ||||||||||
| Title: | Inhibition of PDGFR phosphorylation and Src and Akt activity by GN963 leads to therapy of human pancreatic cancer growing orthotopically in nude mice. | ||||||||||
| Author: | Baker, Cheryl H|Trevino, Jose G|Summy, Justin M|Zhang, Fahao|Caron, Alexis|Nesbit, Mark|Gallick, Gary E|Fidler, Isaiah J | ||||||||||
| PMID: | 16773192 | ||||||||||
| 8. | |||||||||||
| Journal: | Cancer Biol Ther. 2006 Dec;5(12):1640-6. Epub 2006 Dec 5. | ||||||||||
| Title: | Identification of fibroblast heterogeneity in the tumor microenvironment. | ||||||||||
| Author: | Sugimoto, Hikaru|Mundel, Thomas M|Kieran, Mark W|Kalluri, Raghu | ||||||||||
| PMID: | 17106243 | ||||||||||
| 9. | |||||||||||
| Journal: | Clin Cancer Res. 2007 Jan 1;13(1):299-306. | ||||||||||
| Title: | Emerging role of platelet-derived growth factor receptor-beta inhibition in radioimmunotherapy of experimental pancreatic cancer. | ||||||||||
| Author: | Baranowska-Kortylewicz, Janina|Abe, Michio|Nearman, Jessica|Enke, Charles A | ||||||||||
| PMID: | 17200369 | ||||||||||
| 10. | |||||||||||
| Journal: | J Clin Invest. 2007 Aug;117(8):2114-22. | ||||||||||
| Title: | Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content. | ||||||||||
| Author: | McCarty, Marya F|Somcio, Ray J|Stoeltzing, Oliver|Wey, Jane|Fan, Fan|Liu, Wenbiao|Bucana, Corazon|Ellis, Lee M | ||||||||||
| PMID: | 17641778 | ||||||||||
| 11. | |||||||||||
| Journal: | Int J Radiat Oncol Biol Phys. 2008 Jul 1;71(3):873-9. | ||||||||||
| Title: | SU11248 (sunitinib) sensitizes pancreatic cancer to the cytotoxic effects of ionizing radiation. | ||||||||||
| Author: | Cuneo, Kyle C|Geng, Ling|Fu, Allie|Orton, Darren|Hallahan, Dennis E|Chakravarthy, Anuradha Bapsi | ||||||||||
| PMID: | 18514780 | ||||||||||
| 12. | |||||||||||
| Journal: | Biologics. 2008 Dec;2(4):707-15. | ||||||||||
| Title: | Small molecule tyrosine kinase inhibitors in pancreatic cancer. | ||||||||||
| Author: | Gupta, Sachin|El-Rayes, Bassel F | ||||||||||
| PMID: | 19707451 | ||||||||||
| 13. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2009 Feb;36(2):187-92. | ||||||||||
| Title: | [Treatments of epithelial ovarian cancer by histologic subtype]. | ||||||||||
| Author: | Sugiyama, Toru|Kumagai, Seisuke|Hatayama, Shinya | ||||||||||
| PMID: | 19223734 | ||||||||||
| 14. | |||||||||||
| Journal: | Int J Radiat Oncol Biol Phys. 2009 Nov 1;75(3):862-9. | ||||||||||
| Title: | Radiosensitization effect of STI-571 on pancreatic cancer cells in vitro. | ||||||||||
| Author: | Chung, Hye Won|Wen, Jing|Lim, Jong-Baeck|Bang, SeungMin|Park, Seung Woo|Song, Si Young | ||||||||||
| PMID: | 19801102 | ||||||||||
| 15. | |||||||||||
| Journal: | Mol Cancer Ther. 2011 Nov;10(11):2157-67. | ||||||||||
| Title: | Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer. | ||||||||||
| Author: | Taeger, Johannes|Moser, Christian|Hellerbrand, Claus|Mycielska, Maria E|Glockzin, Gabriel|Schlitt, Hans J|Geissler, Edward K|Stoeltzing, Oliver|Lang, Sven A | ||||||||||
| PMID: | 21885862 | ||||||||||
| 16. | |||||||||||
| Journal: | Cancers (Basel). 2011 May 25;3(2):2501-15. | ||||||||||
| Title: | Activation of PDGFr-beta Signaling Pathway after Imatinib and Radioimmunotherapy Treatment in Experimental Pancreatic Cancer. | ||||||||||
| Author: | Abe, Michio|Kortylewicz, Zbigniew P|Enke, Charles A|Mack, Elizabeth|Baranowska-Kortylewicz, Janina | ||||||||||
| PMID: | 24212821 | ||||||||||
| 17. | |||||||||||
| Journal: | J Pharmacol Exp Ther. 2012 Dec;343(3):617-27. | ||||||||||
| Title: | Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. | ||||||||||
| Author: | Glaser, Keith B|Li, Junling|Marcotte, Patrick A|Magoc, Terrance J|Guo, Jun|Reuter, David R|Tapang, Paul|Wei, Ru-Qi|Pease, Lori J|Bui, Mai H|Chen, Zehan|Frey, Robin R|Johnson, Eric F|Osterling, Donald J|Olson, Amanda M|Bouska, Jennifer J|Luo, Yanping|Curti | ||||||||||
| PMID: | 22935731 | ||||||||||
| 18. | |||||||||||
| Journal: | PLoS One. 2012;7(3):e33414. | ||||||||||
| Title: | The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic cancer cells. | ||||||||||
| Author: | Ma, Yong-Chao|Shi, Chong|Zhang, Yao-Nan|Wang, Lan-Ge|Liu, Hao|Jia, Hong-Ti|Zhang, Yu-Xiang|Sarkar, Fazlul H|Wang, Ze-Sheng | ||||||||||
| PMID: | 22479394 | ||||||||||
| 19. | |||||||||||
| Journal: | Med Oncol. 2012 Dec;29(4):2824-30. | ||||||||||
| Title: | PDGFRbeta expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker. | ||||||||||
| Author: | Yuzawa, Sayaka|Kano, Mitsunobu R|Einama, Takahiro|Nishihara, Hiroshi | ||||||||||
| PMID: | 22403002 | ||||||||||
| 20. | |||||||||||
| Journal: | Ann Oncol. 2012 Apr;23(4):942-7. | ||||||||||
| Title: | A dose escalation study of gemcitabine plus oxaliplatin in combination with imatinib for gemcitabine-refractory advanced pancreatic adenocarcinoma. | ||||||||||
| Author: | Starling, N|Hawkes, E A|Chau, I|Watkins, D|Thomas, J|Webb, J|Brown, G|Thomas, K|Barbachano, Y|Oates, J|Cunningham, D | ||||||||||
| PMID: | 21750117 | ||||||||||
| 21. | |||||||||||
| Journal: | Invest New Drugs. 2012 Feb;30(1):382-6. | ||||||||||
| Title: | Gemcitabine plus sorafenib in patients with advanced pancreatic cancer: a phase II trial of the University of Chicago Phase II Consortium. | ||||||||||
| Author: | Kindler, Hedy Lee|Wroblewski, Kristen|Wallace, James A|Hall, Michael J|Locker, Gershon|Nattam, Sreenivasa|Agamah, Edem|Stadler, Walter M|Vokes, Everett E | ||||||||||
| PMID: | 20803052 | ||||||||||
| 22. | |||||||||||
| Journal: | Biochem Pharmacol. 2012 Feb 15;83(4):452-61. | ||||||||||
| Title: | Kinome-wide siRNA screening identifies molecular targets mediating the sensitivity of pancreatic cancer cells to Aurora kinase inhibitors. | ||||||||||
| Author: | Xie, Lifang|Kassner, Michelle|Munoz, Ruben M|Que, Qiang Q|Kiefer, Jeff|Zhao, Yu|Mousses, Spyro|Yin, Hongwei H|Von Hoff, Daniel D|Han, Haiyong | ||||||||||
| PMID: | 22100984 | ||||||||||
| 23. | |||||||||||
| Journal: | Mol Imaging Biol. 2013 Aug;15(4):391-400. | ||||||||||
| Title: | Peptide arrays for development of PDGFRbeta Affine molecules. | ||||||||||
| Author: | Marr, Annabell|Nissen, Felix|Maisch, Daniel|Altmann, Annette|Rana, Shoaib|Debus, Jurgen|Huber, Peter E|Haberkorn, Uwe|Askoxylakis, Vasileios | ||||||||||
| PMID: | 23381728 | ||||||||||
| 24. | |||||||||||
| Journal: | Pharmacol Rep. 2013;65(3):682-8. | ||||||||||
| Title: | Cucurmosin induces the apoptosis of human pancreatic cancer CFPAC-1 cells by inactivating the PDGFR-beta signalling pathway. | ||||||||||
| Author: | Xie, Jieming|Wang, Congfei|Zhang, Baoming|Yang, Aiqin|Yin, Qiang|Huang, Heguang|Chen, Minghuang | ||||||||||
| PMID: | 23950591 | ||||||||||
| 25. | |||||||||||
| Journal: | EJNMMI Res. 2014 Feb 16;4(1):9. | ||||||||||
| Title: | Synergism of peptide receptor-targeted Auger electron radiation therapy with anti-angiogenic compounds in a mouse model of neuroendocrine tumors. | ||||||||||
| Author: | Wicki, Andreas|Wild, Damian|Pretre, Vincent|Mansi, Rosalba|Orleth, Annette|Reubi, Jean-Claude|Rochlitz, Christoph|Mamot, Christoph|Macke, Helmut R|Christofori, Gerhard | ||||||||||
| PMID: | 24528513 | ||||||||||
| 26. | |||||||||||
| Journal: | Cell. 2014 Apr 10;157(2):382-94. | ||||||||||
| Title: | Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor beta signaling. | ||||||||||
| Author: | Weissmueller, Susann|Manchado, Eusebio|Saborowski, Michael|Morris, John P 4th|Wagenblast, Elvin|Davis, Carrie A|Moon, Sung-Hwan|Pfister, Neil T|Tschaharganeh, Darjus F|Kitzing, Thomas|Aust, Daniela|Markert, Elke K|Wu, Jianmin|Grimmond, Sean M|Pilarsky, Ch | ||||||||||
| PMID: | 24725405 | ||||||||||
| 27. | |||||||||||
| Journal: | Exp Cell Res. 2014 Aug 15;326(2):307-14. | ||||||||||
| Title: | Induction of pancreatic cancer cell migration by an autocrine epidermal growth factor receptor activation. | ||||||||||
| Author: | Stock, Anna-Maria|Hahn, Stephan A|Troost, Gabriele|Niggemann, Bernd|Zanker, Kurt S|Entschladen, Frank | ||||||||||
| PMID: | 24810090 | ||||||||||
| 28. | |||||||||||
| Journal: | Cancer Sci. 2014 Sep;105(9):1116-23. | ||||||||||
| Title: | Expression of platelet-derived growth factor receptor beta is maintained by Prox1 in lymphatic endothelial cells and is required for tumor lymphangiogenesis. | ||||||||||
| Author: | Miyazaki, Hideki|Yoshimatsu, Yasuhiro|Akatsu, Yuichi|Mishima, Koichi|Fukayama, Masashi|Watabe, Tetsuro|Miyazono, Kohei | ||||||||||
| PMID: | 24981766 | ||||||||||
| 29. | |||||||||||
| Journal: | Clin Cancer Res. 2015 Aug 1;21(15):3412-9. | ||||||||||
| Title: | First-in-Human Pharmacokinetic and Pharmacodynamic Study of the Dual m-TORC 1/2 Inhibitor AZD2014. | ||||||||||
| Author: | Basu, Bristi|Dean, Emma|Puglisi, Martina|Greystoke, Alastair|Ong, Michael|Burke, Wendy|Cavallin, Maria|Bigley, Graham|Womack, Christopher|Harrington, Elizabeth A|Green, Stephen|Oelmann, Elisabeth|de Bono, Johann S|Ranson, Malcolm|Banerji, Udai | ||||||||||
| PMID: | 25805799 | ||||||||||
| 30. | |||||||||||
| Journal: | Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E864-73. | ||||||||||
| Title: | Functional malignant cell heterogeneity in pancreatic neuroendocrine tumors revealed by targeting of PDGF-DD. | ||||||||||
| Author: | Cortez, Eliane|Gladh, Hanna|Braun, Sebastian|Bocci, Matteo|Cordero, Eugenia|Bjorkstrom, Niklas K|Miyazaki, Hideki|Michael, Iacovos P|Eriksson, Ulf|Folestad, Erika|Pietras, Kristian | ||||||||||
| PMID: | 26831065 | ||||||||||
| 31. | |||||||||||
| Journal: | Anticancer Res. 2016 Oct;36(10):5025-5030. | ||||||||||
| Title: | Antiangiogenic Therapy in Pancreatic Neuroendocrine Tumors. | ||||||||||
| Author: | Capozzi, Monica|VON Arx, Claudia|DE Divitiis, Chiara|Ottaiano, Alessandro|Tatangelo, Fabiana|Romano, Giovanni Maria|Tafuto, Salvatore | ||||||||||
| PMID: | 27798861 | ||||||||||
| 32. | |||||||||||
| Journal: | Cancer Genet. 2016 Dec;209(12):567-581. | ||||||||||
| Title: | Molecular targeted therapy for pancreatic adenocarcinoma: A review of completed and ongoing late phase clinical trials. | ||||||||||
| Author: | Mosquera, Catalina|Maglic, Dino|Zervos, Emmanuel E | ||||||||||
| PMID: | 27613577 | ||||||||||
| 33. | |||||||||||
| Journal: | Oncotarget. 2016 Jul 26;7(30):48265-48279. | ||||||||||
| Title: | The pancreatic niche inhibits the effectiveness of sunitinib treatment of pancreatic cancer. | ||||||||||
| Author: | Martinez-Bosch, Neus|Guerrero, Pedro Enrique|Moreno, Mireia|Jose, Anabel|Iglesias, Mar|Munne-Collado, Jessica|Anta, Hector|Gibert, Joan|Orozco, Carlos Alberto|Vinaixa, Judith|Fillat, Cristina|Vinals, Francesc|Navarro, Pilar | ||||||||||
| PMID: | 27374084 | ||||||||||
| 34. | |||||||||||
| Journal: | World J Surg. 2016 Aug;40(8):1977-84. | ||||||||||
| Title: | Impact of p53 and PDGFR-beta Expression on Metastasis and Prognosis of Patients with Pancreatic Cancer. | ||||||||||
| Author: | Kurahara, Hiroshi|Maemura, Kosei|Mataki, Yuko|Sakoda, Masahiko|Shinchi, Hiroyuki|Natsugoe, Shoji | ||||||||||
| PMID: | 26940582 | ||||||||||
| 35. | |||||||||||
| Journal: | Pancreas. 2017 Apr;46(4):557-566. | ||||||||||
| Title: | MK2461, a Multitargeted Kinase Inhibitor, Suppresses the Progression of Pancreatic Cancer by Disrupting the Interaction Between Pancreatic Cancer Cells and Stellate Cells. | ||||||||||
| Author: | Inoue, Koetsu|Ohtsuka, Hideo|Tachikawa, Masanori|Motoi, Fuyuhiko|Shijo, Masahiro|Douchi, Daisuke|Kawasaki, Shuhei|Kawaguchi, Kei|Masuda, Kunihiro|Fukase, Koji|Naitoh, Takeshi|Katayose, Yu|Egawa, Shinichi|Unno, Michiaki|Terasaki, Tetsuya | ||||||||||
| PMID: | 28196027 | ||||||||||
| 36. | |||||||||||
| Journal: | J Gastrointest Oncol. 2017 Feb;8(1):164-172. | ||||||||||
| Title: | Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis. | ||||||||||
| Author: | Borazanci, Erkut|Millis, Sherri Z|Kimbrough, Jeffery|Doll, Nancy|Von Hoff, Daniel|Ramanathan, Ramesh K | ||||||||||
| PMID: | 28280620 | ||||||||||
| 37. | |||||||||||
| Journal: | Mol Cancer Ther. 2017 Sep;16(9):1729-1738. | ||||||||||
| Title: | Cotargeting of MEK and PDGFR/STAT3 Pathways to Treat Pancreatic Ductal Adenocarcinoma. | ||||||||||
| Author: | Sahu, Nisebita|Chan, Emily|Chu, Felix|Pham, Thinh|Koeppen, Hartmut|Forrest, William|Merchant, Mark|Settleman, Jeff | ||||||||||
| PMID: | 28619758 | ||||||||||
| 38. | |||||||||||
| Journal: | Lung Cancer. 2017 Sep;111:108-115. | ||||||||||
| Title: | Phase II study of olaratumab with paclitaxel/carboplatin (P/C) or P/C alone in previously untreated advanced NSCLC. | ||||||||||
| Author: | Gerber, David E|Swanson, Paul|Lopez-Chavez, Ariel|Wong, Lucas|Dowlati, Afshin|Pennell, Nathan A|Cronier, Damien M|Qin, Amy|Ilaria, Robert Jr|Cosaert, Jan|Shahir, Ashwin|Baggstrom, Maria Q | ||||||||||
| PMID: | 28838379 | ||||||||||
| 39. | |||||||||||
| Journal: | Expert Opin Pharmacother. 2018 May;19(7):759-764. | ||||||||||
| Title: | Masitinib in treatment of pancreatic cancer. | ||||||||||
| Author: | Waheed, Anem|Purvey, Sneha|Saif, Muhammad Wasif | ||||||||||
| PMID: | 29638149 | ||||||||||