Primary Site >> Liver Cancer

Gene >> NFE2L2

Journal: Biochem J. 2004 Jun 1;380(Pt 2):515-21.
Title: Transcription factor Nrf2/MafK regulates rat placental glutathione S-transferase gene during hepatocarcinogenesis.
Author: Ikeda, Hiromi|Nishi, Shinzo|Sakai, Masaharu
PMID: 14960151
Journal: J Biol Chem. 2006 Mar 10;281(10):6734-41.
Title: CCAAT enhancer-binding protein alpha suppresses the rat placental glutathione S-transferase gene in normal liver.
Author: Ikeda, Hiromi|Omoteyama, Kazuki|Yoshida, Kazuhiko|Nishi, Shinzo|Sakai, Masaharu
PMID: 16407263
Journal: Biochem Pharmacol. 2006 Aug 14;72(4):455-62.
Title: Bucillamine induces glutathione biosynthesis via activation of the transcription factor Nrf2.
Author: Wielandt, Ana M|Vollrath, Valeska|Farias, Marcelo|Chianale, Jose
PMID: 16806086
Journal: Pharm Res. 2008 Apr;25(4):836-44.
Title: Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression.
Author: Prawan, Auemduan|Keum, Young-Sam|Khor, Tin Oo|Yu, Siwang|Nair, Sujit|Li, Wenge|Hu, Longqin|Kong, Ah-Ng Tony
PMID: 17657593
Journal: Toxicol Sci. 2008 May;103(1):46-56.
Title: Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR.
Author: Rosen, Mitchell B|Lee, Janice S|Ren, Hongzu|Vallanat, Beena|Liu, Jie|Waalkes, Michael P|Abbott, Barbara D|Lau, Christopher|Corton, J Christopher
PMID: 18281256
Journal: Hepatology. 2008 Aug;48(2):487-96.
Title: Activation of nuclear factor E2-related factor 2 in hereditary tyrosinemia type 1 and its role in survival and tumor development.
Author: Marhenke, Silke|Lamle, Jutta|Buitrago-Molina, Laura Elisa|Canon, Jose Manuel Fernandez|Geffers, Robert|Finegold, Milton|Sporn, Michael|Yamamoto, Masayuki|Manns, Michael P|Grompe, Markus|Vogel, Arndt
PMID: 18666252
Journal: Med Hypotheses. 2008 Nov;71(5):730-6.
Title: The multifaceted mechanisms for coffee's anti-tumorigenic effect on liver.
Author: Tao, Kai-Shan|Wang, Wen|Wang, Ling|Cao, Da-Yong|Li, Yong-Qi|Wu, Sheng-Xi|Dou, Ke-Feng
PMID: 18701223
Journal: Planta Med. 2009 Oct;75(12):1314-8.
Title: Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2.
Author: Lee, Saet Byoul|Kim, Chul Young|Lee, Hee Ju|Yun, Ji Ho|Nho, Chu Won
PMID: 19452436
Journal: Nat Cell Biol. 2010 Mar;12(3):213-23.
Title: The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Author: Komatsu, Masaaki|Kurokawa, Hirofumi|Waguri, Satoshi|Taguchi, Keiko|Kobayashi, Akira|Ichimura, Yoshinobu|Sou, Yu-Shin|Ueno, Izumi|Sakamoto, Ayako|Tong, Kit I|Kim, Mihee|Nishito, Yasumasa|Iemura, Shun-ichiro|Natsume, Tohru|Ueno, Takashi|Kominami, Eiki|Motoh
PMID: 20173742
Journal: Cancer Prev Res (Phila). 2010 Jun;3(6):753-63.
Title: Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis.
Author: Bishayee, Anupam|Barnes, Kendra F|Bhatia, Deepak|Darvesh, Altaf S|Carroll, Richard T
PMID: 20501860
Journal: Toxicol Appl Pharmacol. 2010 Sep 1;247(2):129-37.
Title: Sulforaphane protects Microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response.
Author: Gan, Nanqin|Mi, Lixin|Sun, Xiaoyun|Dai, Guofei|Chung, Fung-Lung|Song, Lirong
PMID: 20600217
Journal: Chem Res Toxicol. 2010 Sep 20;23(9):1477-84.
Title: Activation of Nrf2 by microcystin-LR provides advantages for liver cancer cell growth.
Author: Gan, Nanqin|Sun, Xiaoyun|Song, Lirong
PMID: 20722399
Journal: AAPS J. 2011 Mar;13(1):1-13.
Title: Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis.
Author: Wu, Tien-Yuan|Khor, Tin Oo|Saw, Constance Lay Lay|Loh, Stephanie C|Chen, Alvin I|Lim, Soon Sung|Park, Jung Han Yoon|Cai, Li|Kong, Ah-Ng Tony
PMID: 20967519
Journal: Carcinogenesis. 2011 Jun;32(6):888-96.
Title: Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms.
Author: Bishayee, Anupam|Bhatia, Deepak|Thoppil, Roslin J|Darvesh, Altaf S|Nevo, Eviatar|Lansky, Ephraim P
PMID: 21389260
Journal: Toxicology. 2011 May 10;283(2-3):109-17.
Title: Indole-3-carbinol enhances oxidative stress responses resulting in the induction of preneoplastic liver cell lesions in partially hepatectomized rats initiated with diethylnitrosamine.
Author: Shimamoto, Keisuke|Dewa, Yasuaki|Ishii, Yuji|Kemmochi, Sayaka|Taniai, Eriko|Hayashi, Hitomi|Imaoka, Masako|Morita, Reiko|Kuwata, Kazunori|Suzuki, Kazuhiko|Shibutani, Makoto|Mitsumori, Kunitoshi
PMID: 21396975
Journal: J Cell Biol. 2011 Apr 18;193(2):275-84.
Title: Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.
Author: Inami, Yoshihiro|Waguri, Satoshi|Sakamoto, Ayako|Kouno, Tsuguka|Nakada, Kazuto|Hino, Okio|Watanabe, Sumio|Ando, Jin|Iwadate, Manabu|Yamamoto, Masayuki|Lee, Myung-Shik|Tanaka, Keiji|Komatsu, Masaaki
PMID: 21482715
Journal: Autophagy. 2011 Sep;7(9):1088-90. Epub 2011 Sep 1.
Title: Potential role of p62 in tumor development.
Author: Komatsu, Masaaki
PMID: 21617386
Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Jun;27(6):608-10.
Title: [Expression and distribution of Nrf2 in several hepatocellular carcinoma cell lines].
Author: Ma, Ren-Qiang|Zhang, Ming-xin|Wang, Jian-sheng|Cai, Hui|Yeer, Mai-ke|Duan, Xiao-yi
PMID: 21651857
Journal: Free Radic Biol Med. 2011 Nov 1;51(9):1675-85.
Title: Transcriptional modulation of the NAD(P)H:quinone oxidoreductase 1 by mercury in human hepatoma HepG2 cells.
Author: Amara, Issa E A|El-Kadi, Ayman O S
PMID: 21843634
Journal: Hepatology. 2012 Jun;55(6):1820-9.
Title: Amplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways.
Author: Chen, Qiang|Li, Wenjiao|Wan, Yunyan|Xia, Xiaochun|Wu, Qiao|Chen, Yanling|Lai, Zhide|Yu, Chundong|Li, Wengang
PMID: 22213475
Journal: J Biol Chem. 2012 Mar 23;287(13):9873-86.
Title: Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis.
Author: Niture, Suryakant K|Jaiswal, Anil K
PMID: 22275372
Journal: Cancer Sci. 2012 Apr;103(4):760-6.
Title: Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma.
Author: Inoue, Daisuke|Suzuki, Takashi|Mitsuishi, Yoichiro|Miki, Yasuhiro|Suzuki, Satoshi|Sugawara, Shunichi|Watanabe, Mika|Sakurada, Akira|Endo, Chiaki|Uruno, Akira|Sasano, Hironobu|Nakagawa, Takayuki|Satoh, Kennichi|Tanaka, Nobuyuki|Kubo, Hiroshi|Motohashi, Hoz
PMID: 22320446
Journal: J Toxicol Sci. 2012;37(2):297-306.
Title: Liver tumor promoting effect of etofenprox in rats and its possible mechanism of action.
Author: Hojo, Yuri|Shiraki, Ayako|Tsuchiya, Takuma|Shimamoto, Keisuke|Ishii, Yuji|Suzuki, Kazuhiko|Shibutani, Makoto|Mitsumori, Kunitoshi
PMID: 22467020
Journal: Anticancer Drugs. 2012 Jul;23(6):651-8.
Title: The role of Nrf2 and apoptotic signaling pathways in oroxylin A-mediated responses in HCT-116 colorectal adenocarcinoma cells and xenograft tumors.
Author: Hu, Rong|Chen, Nan|Yao, Jing|Zhao, Qing|Zhang, Fengyi|Li, Zhi-Yu|You, Qi-Dong|Guo, Qing-Long
PMID: 22526619
Journal: Nat Genet. 2012 May 6;44(6):694-8.
Title: Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma.
Author: Guichard, Cecile|Amaddeo, Giuliana|Imbeaud, Sandrine|Ladeiro, Yannick|Pelletier, Laura|Maad, Ichrafe Ben|Calderaro, Julien|Bioulac-Sage, Paulette|Letexier, Melanie|Degos, Francoise|Clement, Bruno|Balabaud, Charles|Chevet, Eric|Laurent, Alexis|Couchy, Gabr
PMID: 22561517
Journal: Biochimie. 2012 Sep;94(9):1876-83.
Title: Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells.
Author: Smirnova, Olga A|Isaguliants, Maria G|Hyvonen, Mervi T|Keinanen, Tuomo A|Tunitskaya, Vera L|Vepsalainen, Jouko|Alhonen, Leena|Kochetkov, Sergey N|Ivanov, Alexander V
PMID: 22579641
Journal: Toxicology. 2012 Sep 28;299(2-3):69-79.
Title: Dietary modulation of the biotransformation and genotoxicity of aflatoxin B(1).
Author: Gross-Steinmeyer, Kerstin|Eaton, David L
PMID: 22640941
Journal: J Toxicol Sci. 2012;37(3):491-501.
Title: Liver tumor promoting effect of omeprazole in rats and its possible mechanism of action.
Author: Hayashi, Hitomi|Shimamoto, Keisuke|Taniai, Eriko|Ishii, Yuji|Morita, Reiko|Suzuki, Kazuhiko|Shibutani, Makoto|Mitsumori, Kunitoshi
PMID: 22687989
Journal: PLoS One. 2012;7(7):e41676.
Title: Induction of heme oxygenase-1 inhibits cell death in crotonaldehyde-stimulated HepG2 cells via the PKC-delta-p38-Nrf2 pathway.
Author: Lee, Seung Eun|Yang, Hana|Jeong, Seong Il|Jin, Young-Ho|Park, Cheung-Seog|Park, Yong Seek
PMID: 22848562
Journal: Curr Cancer Drug Targets. 2012 Nov 1;12(9):1173-90.
Title: Chemoprevention of hepatocarcinogenesis with dietary isoprenic derivatives: cellular and molecular aspects.
Author: Ong, Thomas Prates|Cardozo, Monica Testoni|de Conti, Aline|Moreno, Fernando Salvador
PMID: 22873216
Journal: Curr Cancer Drug Targets. 2012 Nov 1;12(9):1244-57.
Title: Black currant anthocyanins abrogate oxidative stress through Nrf2- mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma.
Author: Thoppil, Roslin J|Bhatia, Deepak|Barnes, Kendra F|Haznagy-Radnai, Erzsebet|Hohmann, Judit|Darvesh, Altaf S|Bishayee, Anupam
PMID: 22873220
Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2012 Aug;32(8):1093-7.
Title: [Small interfering RNA-mediated Nrf2 gene knockdown enhances hirsutanols A-induced cytotoxicity in cancer cells].
Author: Ma, Jianguo|Li, Houjin|Deng, Rong|Feng, Gongkan|Zhu, Xiaofeng
PMID: 22931598
Journal: J Ethnopharmacol. 2012 Nov 21;144(2):416-24.
Title: Induction of quinone oxidoreductase 1 enzyme by Rhazya stricta through Nrf2-dependent mechanism.
Author: El Gendy, Mohamed A M|Ali, Badreldin H|Michail, Karim|Siraki, Arno G|El-Kadi, Ayman O S
PMID: 23026305
Journal: Biomed Pharmacother. 2012 Dec;66(8):612-6.
Title: STAT3 & Cytochrome P450 2C9: a novel signaling pathway in liver cancer stem cells.
Author: Myung, Sun Jung|Yoon, Jung-Hwan|Yu, Su Jong
PMID: 23089473
Journal: Oncoimmunology. 2012 Dec 1;1(9):1612-1613.
Title: Next-generation sequencing identified new oncogenes and tumor suppressor genes in human hepatic tumors.
Author: Amaddeo, Giuliana|Guichard, Cecile|Imbeaud, Sandrine|Zucman-Rossi, Jessica
PMID: 23264911
Journal: J Nutr Biochem. 2013 Jan;24(1):178-87.
Title: Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis.
Author: Bishayee, Anupam|Thoppil, Roslin J|Darvesh, Altaf S|Ohanyan, Vahagn|Meszaros, J Gary|Bhatia, Deepak
PMID: 22841394
Journal: Toxicol In Vitro. 2013 Feb;27(1):149-56.
Title: Xanthohumol induces phase II enzymes via Nrf2 in human hepatocytes in vitro.
Author: Krajka-Kuzniak, Violetta|Paluszczak, Jaroslaw|Baer-Dubowska, Wanda
PMID: 23085367
Journal: Drug Metab Pharmacokinet. 2013;28(3):265-8. Epub 2012 Dec 11.
Title: Cytotoxic effects of benzbromarone and its 1'-hydroxy metabolite in human hepatocarcinoma FLC4 cells cultured on micro-space cell culture plates.
Author: Kobayashi, Kaoru|Kajiwara, Eri|Ishikawa, Masayuki|Mimura, Hanaka|Oka, Hidenobu|Ejiri, Yoko|Hosoda, Masaya|Chiba, Kan
PMID: 23229783
Journal: Dig Dis Sci. 2013 Jun;58(6):1615-26.
Title: The noncytotoxic dose of sorafenib sensitizes Bel-7402/5-FU cells to 5-FU by down-regulating 5-FU-induced Nrf2 expression.
Author: Zhou, Suna|Ye, Wenguang|Duan, Xiaoyi|Zhang, Mingxin|Wang, Jiansheng
PMID: 23314856
Journal: Toxicology. 2013 Apr 5;306:114-23.
Title: Cadmium telluride quantum dots cause oxidative stress leading to extrinsic and intrinsic apoptosis in hepatocellular carcinoma HepG2 cells.
Author: Nguyen, Kathy C|Willmore, William G|Tayabali, Azam F
PMID: 23485651
Journal: Genome Res. 2013 May;23(5):800-11.
Title: Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay.
Author: Kheradpour, Pouya|Ernst, Jason|Melnikov, Alexandre|Rogov, Peter|Wang, Li|Zhang, Xiaolan|Alston, Jessica|Mikkelsen, Tarjei S|Kellis, Manolis
PMID: 23512712
Journal: Hepatology. 2013 Sep;58(3):1143-52.
Title: The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice.
Author: Buitrago-Molina, Laura Elisa|Marhenke, Silke|Longerich, Thomas|Sharma, Amar Deep|Boukouris, Aristeidis E|Geffers, Robert|Guigas, Bruno|Manns, Michael P|Vogel, Arndt
PMID: 23526443
Journal: PLoS One. 2013 May 16;8(5):e63388.
Title: Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis.
Author: Endo, Hitoshi|Niioka, Maki|Kobayashi, Noriko|Tanaka, Mamoru|Watanabe, Tetsu
PMID: 23696823
Journal: Hepatology. 2013 Nov;58(5):1693-702.
Title: Identification of driver genes in hepatocellular carcinoma by exome sequencing.
Author: Cleary, Sean P|Jeck, William R|Zhao, Xiaobei|Chen, Kui|Selitsky, Sara R|Savich, Gleb L|Tan, Ting-Xu|Wu, Michael C|Getz, Gad|Lawrence, Michael S|Parker, Joel S|Li, Jinyu|Powers, Scott|Kim, Hyeja|Fischer, Sandra|Guindi, Maha|Ghanekar, Anand|Chiang, Derek Y
PMID: 23728943
Journal: Oxid Med Cell Longev. 2013;2013:763257.
Title: Role of the Nrf2-ARE pathway in liver diseases.
Author: Shin, Sang Mi|Yang, Ji Hye|Ki, Sung Hwan
PMID: 23766860
Journal: Mutat Res. 2013 Aug 15;755(2):90-9.
Title: Somatic changes in primary liver cancer in Russia: a pilot study.
Author: Kalinina, Olga|Marchio, Agnes|Urbanskii, Aleksandr I|Tarkova, Aleksandra B|Rebbani, Khadija|Granov, Dmitri A|Dejean, Anne|Generalov, Mikhail I|Pineau, Pascal
PMID: 23830926
Journal: Biochem Biophys Res Commun. 2013 Sep 27;439(3):333-9.
Title: Depletion of hepatoma-derived growth factor-related protein-3 induces apoptotic sensitization of radioresistant A549 cells via reactive oxygen species-dependent p53 activation.
Author: Yun, Hong Shik|Hong, Eun-Hee|Lee, Su-Jae|Baek, Jeong-Hwa|Lee, Chang-Woo|Yim, Ji-Hye|Um, Hong-Duck|Hwang, Sang-Gu
PMID: 24012673
Journal: J Cell Sci. 2013 Dec 15;126(Pt 24):5657-69.
Title: Oncogene PKCepsilon controls INrf2-Nrf2 interaction in normal and cancer cells through phosphorylation of INrf2.
Author: Niture, Suryakant K|Gnatt, Averell|Jaiswal, Anil K
PMID: 24127568
Journal: Lipids Health Dis. 2013 Nov 4;12:165.
Title: Nrf2 deletion causes "benign" simple steatosis to develop into nonalcoholic steatohepatitis in mice fed a high-fat diet.
Author: Wang, Chunhua|Cui, Yizhe|Li, Chunyan|Zhang, Yanhua|Xu, Shang|Li, Xiaochong|Li, Hong|Zhang, Xiuying
PMID: 24188280
Journal: World J Gastroenterol. 2013 Dec 21;19(47):8873-9.
Title: Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma.
Author: Gu, De-Leung|Chen, Yen-Hsieh|Shih, Jou-Ho|Lin, Chi-Hung|Jou, Yuh-Shan|Chen, Chian-Feng
PMID: 24379610
Journal: Biochim Biophys Acta. 2014 Jan;1840(1):219-44.
Title: Berberine and S allyl cysteine mediated amelioration of DEN+CCl4 induced hepatocarcinoma.
Author: Sengupta, Dipanwita|Chowdhury, Kaustav Dutta|Sarkar, Avik|Paul, Soumosish|Sadhukhan, Gobinda Chandra
PMID: 23999088
Journal: J Gastroenterol. 2014 Sep;49(9):1324-32.
Title: Frequent alteration of the protein synthesis of enzymes for glucose metabolism in hepatocellular carcinomas.
Author: Shimizu, Takayuki|Inoue, Ken-ichi|Hachiya, Hiroyuki|Shibuya, Norisuke|Shimoda, Mitsugi|Kubota, Keiichi
PMID: 24203292
Journal: Hepatology. 2014 Jun;59(6):2371-82.
Title: NF-E2-related factor 2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice.
Author: Shirasaki, Keiichi|Taguchi, Keiko|Unno, Michiaki|Motohashi, Hozumi|Yamamoto, Masayuki
PMID: 24443206
Journal: Nat Rev Gastroenterol Hepatol. 2014 Jun;11(6):340-9.
Title: Exploration of liver cancer genomes.
Author: Shibata, Tatsuhiro|Aburatani, Hiroyuki
PMID: 24473361
Journal: Cancer Prev Res (Phila). 2014 Jul;7(7):658-65.
Title: Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold.
Author: Johnson, Natalie M|Egner, Patricia A|Baxter, Victoria K|Sporn, Michael B|Wible, Ryan S|Sutter, Thomas R|Groopman, John D|Kensler, Thomas W|Roebuck, Bill D
PMID: 24662598
Journal: PLoS One. 2014 Apr 1;9(4):e93599.
Title: Maotai ameliorates diethylnitrosamine-initiated hepatocellular carcinoma formation in mice.
Author: Yi, Xu|Long, Li|Yang, Chunzhang|Lu, Yingying|Cheng, Mingliang
PMID: 24690765
Journal: Mol Pharm. 2014 Jun 2;11(6):1856-68.
Title: The expression of genes involved in hepatocellular carcinoma chemoresistance is affected by mitochondrial genome depletion.
Author: Gonzalez-Sanchez, Ester|Marin, Jose J G|Perez, Maria J
PMID: 24824514
Journal: Biochem Biophys Res Commun. 2014 Jul 11;449(4):471-6.
Title: Knockdown of hepatoma-derived growth factor-related protein-3 induces apoptosis of H1299 cells via ROS-dependent and p53-independent NF-kappaB activation.
Author: Yun, Hong Shik|Baek, Jeong-Hwa|Yim, Ji-Hye|Lee, Su-Jae|Lee, Chang-Woo|Song, Jie-Young|Um, Hong-Duck|Park, Jong Kuk|Park, In-Chul|Hwang, Sang-Gu
PMID: 24857986
Journal: Acta Neuropathol Commun. 2014 May 3;2:50.
Title: Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.
Author: Tanji, Kunikazu|Miki, Yasuo|Ozaki, Taku|Maruyama, Atsushi|Yoshida, Hidemi|Mimura, Junsei|Matsumiya, Tomoh|Mori, Fumiaki|Imaizumi, Tadaatsu|Itoh, Ken|Kakita, Akiyoshi|Takahashi, Hitoshi|Wakabayashi, Koichi
PMID: 24886973
Journal: Antioxid Redox Signal. 2014 Dec 20;21(18):2498-514.
Title: The PTEN/NRF2 axis promotes human carcinogenesis.
Author: Rojo, Ana I|Rada, Patricia|Mendiola, Marta|Ortega-Molina, Ana|Wojdyla, Katarzyna|Rogowska-Wrzesinska, Adelina|Hardisson, David|Serrano, Manuel|Cuadrado, Antonio
PMID: 24892215
Journal: Cancer Prev Res (Phila). 2014 Jul;7(7):653-7.
Title: Of mice, rats, and men: could Nrf2 activation protect against aflatoxin heptocarcinogenesis in humans?
Author: Eaton, David L|Schaupp, Christopher M
PMID: 24934619
Journal: J Hepatol. 2014 Nov;61(5):1178-83.
Title: Paediatric hepatocellular carcinoma due to somatic CTNNB1 and NFE2L2 mutations in the setting of inherited bi-allelic ABCB11 mutations.
Author: Vilarinho, Silvia|Erson-Omay, E Zeynep|Harmanci, Akdes Serin|Morotti, Raffaella|Carrion-Grant, Geneive|Baranoski, Jacob|Knisely, A S|Ekong, Udeme|Emre, Sukru|Yasuno, Katsuhito|Bilguvar, Kaya|Gunel, Murat
PMID: 25016225
Journal: Biochem Pharmacol. 2014 Sep 15;91(2):168-80.
Title: AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells.
Author: Sid, Brice|Glorieux, Christophe|Valenzuela, Manuel|Rommelaere, Guillaume|Najimi, Mustapha|Dejeans, Nicolas|Renard, Patricia|Verrax, Julien|Calderon, Pedro Buc
PMID: 25058527
Journal: J Hepatol. 2014 Dec;61(6):1312-20.
Title: The genomic landscape of hepatoblastoma and their progenies with HCC-like features.
Author: Eichenmuller, Melanie|Trippel, Franziska|Kreuder, Michaela|Beck, Alexander|Schwarzmayr, Thomas|Haberle, Beate|Cairo, Stefano|Leuschner, Ivo|von Schweinitz, Dietrich|Strom, Tim M|Kappler, Roland
PMID: 25135868
Journal: Eur J Pharmacol. 2014 Oct 15;741:247-53.
Title: Sulforaphane inhibition of TPA-mediated PDCD4 downregulation contributes to suppression of c-Jun and induction of p21-dependent Nrf2 expression.
Author: Cho, Jong-Ho|Kim, Young-Woo|Choi, Bu Young|Keum, Young-Sam
PMID: 25169428
Journal: Sichuan Da Xue Xue Bao Yi Xue Ban. 2014 Sep;45(5):739-43.
Title: [The apoptotic mechanism of hepatocellular carcinoma cell line (HepG2) induced by arsenic trioxide].
Author: Zhao, Wei|Hu, Ya-Nan|Jiang, Xue-Jun|Chen, Cheng-Zhi|Zhang, Zun-Zhen
PMID: 25341331
Journal: PLoS One. 2014 Dec 11;9(12):e114912.
Title: A peculiar mutation spectrum emerging from young peruvian patients with hepatocellular carcinoma.
Author: Marchio, Agnes|Bertani, Stephane|Rojas Rojas, Teresa|Doimi, Franco|Terris, Benoit|Deharo, Eric|Dejean, Anne|Ruiz, Eloy|Pineau, Pascal
PMID: 25502816
Journal: Asian Pac J Cancer Prev. 2014;15(23):10439-44.
Title: miR-340 reverses cisplatin resistance of hepatocellular carcinoma cell lines by targeting Nrf2-dependent antioxidant pathway.
Author: Shi, Liang|Chen, Zhan-Guo|Wu, Li-Li|Zheng, Jian-Jian|Yang, Jian-Rong|Chen, Xiao-Fei|Chen, Zeng-Qiang|Liu, Cun-Li|Chi, Sheng-Ying|Zheng, Jia-Ying|Huang, Hai-Xia|Lin, Xiang-Yang|Zheng, Fang
PMID: 25556489
Journal: J Expo Sci Environ Epidemiol. 2015 May;25(3):256-63.
Title: Mutation spectrum of hepatocellular carcinoma from eastern-European patients betrays the impact of a complex exposome.
Author: Tanase, Anna-Maria|Marchio, Agnes|Dumitrascu, Traian|Dima, Simona|Herlea, Vlad|Oprisan, Gabriela|Dejean, Anne|Popescu, Irinel|Pineau, Pascal
PMID: 24736102
Journal: Drug Des Devel Ther. 2014 Dec 17;9:127-46.
Title: Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway.
Author: He, Jin-Lian|Zhou, Zhi-Wei|Yin, Juan-Juan|He, Chang-Qiang|Zhou, Shu-Feng|Yu, Yang
PMID: 25552902
Journal: Toxicol Sci. 2015 Apr;144(2):393-405.
Title: N-hydroxylation of 4-aminobiphenyl by CYP2E1 produces oxidative stress in a mouse model of chemically induced liver cancer.
Author: Wang, Shuang|Sugamori, Kim S|Tung, Aveline|McPherson, J Peter|Grant, Denis M
PMID: 25601990
Journal: Anticancer Drugs. 2015 Jun;26(5):555-64.
Title: A Schiff base derivative for effective treatment of diethylnitrosamine-induced liver cancer in vivo.
Author: Demirci, Selami|Dogan, Aysegul|Basak, Nese|Telci, Dilek|Dede, Bulent|Orhan, Cemal|Tuzcu, Mehmet|Sahin, Kazm|Sahin, Nurhan|Ozercan, Ibrahim Hanifi|Sahin, Fikrettin
PMID: 25714251
Journal: Hepatology. 2015 Sep;62(3):851-62.
Title: Nrf2, but not beta-catenin, mutation represents an early event in rat hepatocarcinogenesis.
Author: Zavattari, Patrizia|Perra, Andrea|Menegon, Silvia|Kowalik, Marta Anna|Petrelli, Annalisa|Angioni, Maria Maddalena|Follenzi, Antonia|Quagliata, Luca|Ledda-Columbano, Giovanna Maria|Terracciano, Luigi|Giordano, Silvia|Columbano, Amedeo
PMID: 25783764
Journal: J Physiol Biochem. 2015 Jun;71(2):227-38.
Title: The activation of the Nrf2/ARE pathway in HepG2 hepatoma cells by phytochemicals and subsequent modulation of phase II and antioxidant enzyme expression.
Author: Krajka-Kuzniak, Violetta|Paluszczak, Jaroslaw|Szaefer, Hanna|Baer-Dubowska, Wanda
PMID: 25800511
Journal: Cell Physiol Biochem. 2015;35(6):2333-48.
Title: MiR-141 Activates Nrf2-Dependent Antioxidant Pathway via Down-Regulating the Expression of Keap1 Conferring the Resistance of Hepatocellular Carcinoma Cells to 5-Fluorouracil.
Author: Shi, Liang|Wu, Lili|Chen, Zhanguo|Yang, Jianrong|Chen, Xiaofei|Yu, Fangyou|Zheng, Fang|Lin, Xiangyang
PMID: 25896253
Journal: Cells. 2015 May 20;4(2):169-77.
Title: What is Known Regarding the Participation of Factor Nrf-2 in Liver Regeneration?
Author: Morales-Gonzalez, Jose A|Madrigal-Santillan, Eduardo|Morales-Gonzalez, Angel|Bautista, Mirandeli|Gayosso-Islas, Evila|Sanchez-Moreno, Cecilia
PMID: 26010752
Journal: Am J Cancer Res. 2015 Mar 15;5(4):1368-81. eCollection 2015.
Title: Disturbance of redox status enhances radiosensitivity of hepatocellular carcinoma.
Author: Sun, Chao|Wang, Zhen-Hua|Liu, Xiong-Xiong|Yang, Li-Na|Wang, Yali|Liu, Yang|Mao, Ai-Hong|Liu, Yuan-Yuan|Zhou, Xin|Di, Cui-Xia|Gan, Lu|Zhang, Hong
PMID: 26101703
Journal: Toxicol Sci. 2015 Oct;147(2):412-24.
Title: Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication.
Author: Sison-Young, Rowena L C|Mitsa, Dimitra|Jenkins, Rosalind E|Mottram, David|Alexandre, Eliane|Richert, Lysiane|Aerts, Helene|Weaver, Richard J|Jones, Robert P|Johann, Esther|Hewitt, Philip G|Ingelman-Sundberg, Magnus|Goldring, Christopher E P|Kitteringham,
PMID: 26160117
Journal: BMC Cancer. 2015 Jul 21;15:531.
Title: Nrf2 is a potential prognostic marker and promotes proliferation and invasion in human hepatocellular carcinoma.
Author: Zhang, Mingxin|Zhang, Chao|Zhang, Lingmin|Yang, Qi|Zhou, Suna|Wen, Qinsheng|Wang, Jingjie
PMID: 26194347
Journal: Int J Clin Exp Pathol. 2015 Jul 1;8(7):8655-62. eCollection 2015.
Title: N-acetylcysteine protects against liver injure induced by carbon tetrachloride via activation of the Nrf2/HO-1 pathway.
Author: Cai, Zhaobin|Lou, Qi|Wang, Fugen|Li, Er|Sun, Jingjing|Fang, Hongying|Xi, Jianjun|Ju, Liping
PMID: 26339453
Journal: Biochim Biophys Acta. 2015 Dec;1852(12):2603-17.
Title: Molecular changes associated with chronic liver damage and neoplastic lesions in a murine model of hereditary tyrosinemia type 1.
Author: Angileri, Francesca|Roy, Vincent|Morrow, Genevieve|Scoazec, Jean Yves|Gadot, Nicolas|Orejuela, Diana|Tanguay, Robert M
PMID: 26360553
Journal: Free Radic Biol Med. 2015 Dec;89:1003-13.
Title: Novel role of TRPV2 in promoting the cytotoxicity of H2O2-mediated oxidative stress in human hepatoma cells.
Author: Ma, Wenbo|Li, Caiyue|Yin, Shikui|Liu, Jingxin|Gao, Chao|Lin, Zuoxian|Huang, Rongqi|Huang, Jufang|Li, Zhiyuan
PMID: 26456053
Journal: Hepatobiliary Pancreat Dis Int. 2015 Oct;14(5):485-91.
Title: Liver expression of Nrf2-related genes in different liver diseases.
Author: Cheng, Ming-Liang|Lu, Yuan-Fu|Chen, Hong|Shen, Zhong-Yang|Liu, Jie
PMID: 26459724
Journal: Cell Death Dis. 2015 Nov 19;6:e1980.
Title: Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation.
Author: Liu, B|Fang, M|He, Z|Cui, D|Jia, S|Lin, X|Xu, X|Zhou, T|Liu, W
PMID: 26583321
Journal: J Nanosci Nanotechnol. 2015 Dec;15(12):9925-37.
Title: Differential Genomic Effects on Signaling Pathways by Two Different CeO2 Nanoparticles in HepG2 Cells.
Author: Thai, Sheau-Fung|Wallace, Kathleen A|Jones, Carlton P|Ren, Hongzu|Castellon, Benjamin T|Crooks, James|Grulke, Eric A|Kitchin, Kirk T
PMID: 26682436
Journal: Food Nutr Res. 2015 Dec 22;59:29884.
Title: Raf/ERK/Nrf2 signaling pathway and MMP-7 expression involvement in the trigonelline-mediated inhibition of hepatocarcinoma cell migration.
Author: Liao, Jung Chun|Lee, Kun Tsung|You, Bang Jau|Lee, Chia Lin|Chang, Wen Te|Wu, Yang Chang|Lee, Hong-Zin
PMID: 26699938
Journal: Toxicol Rep. 2014 Nov 28;2:333-340.
Title: Oxidative stress and cell damage in a model of precancerous lesions and advanced hepatocellular carcinoma in rats.
Author: Moreira, Andrea J|Rodrigues, Graziella|Bona, Silvia|Cerski, Carlos Thadeu|Marroni, Claudio A|Mauriz, Jose L|Gonzalez-Gallego, Javier|Marroni, Norma P
PMID: 28962366
Journal: Environ Toxicol. 2016 Mar;31(3):350-9.
Title: Dichlorodiphenyldichloroethylene exposure reduces r-GCS via suppressed Nrf2 in HepG2 cells.
Author: Jin, Xiaoting|Song, Li|Li, Zhuoyu|Newton, Ian P|Zhao, Meirong|Liu, Weiping
PMID: 25263748
Journal: Arch Toxicol. 2016 Jun;90(6):1449-58.
Title: New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis.
Author: Souza, Terezinha|Jennen, Danyel|van Delft, Joost|van Herwijnen, Marcel|Kyrtoupolos, Soterios|Kleinjans, Jos
PMID: 26238291
Journal: Cancer Sci. 2016 May;107(5):609-18.
Title: CD44 variant 9 is a potential biomarker of tumor initiating cells predicting survival outcome in hepatitis C virus-positive patients with resected hepatocellular carcinoma.
Author: Kakehashi, Anna|Ishii, Naomi|Sugihara, Eiji|Gi, Min|Saya, Hideyuki|Wanibuchi, Hideki
PMID: 26882440
Journal: Oncotarget. 2016 May 31;7(22):32375-93.
Title: Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis.
Author: Kowalik, Marta Anna|Guzzo, Giulia|Morandi, Andrea|Perra, Andrea|Menegon, Silvia|Masgras, Ionica|Trevisan, Elena|Angioni, Maria Maddalena|Fornari, Francesca|Quagliata, Luca|Ledda-Columbano, Giovanna Maria|Gramantieri, Laura|Terracciano, Luigi|Giordano, Sil
PMID: 27070090
Journal: J Exp Med. 2016 May 2;213(5):859-75.
Title: Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma.
Author: Yang, Chun|Tan, Ye-Xiong|Yang, Guang-Zhen|Zhang, Jian|Pan, Yu-Fei|Liu, Chen|Fu, Jing|Chen, Yao|Ding, Zhi-Wen|Dong, Li-Wei|Wang, Hong-Yang
PMID: 27091842
Journal: Mol Cell Biochem. 2016 May;416(1-2):85-97.
Title: Metastasized lung cancer suppression by Morinda citrifolia (Noni) leaf compared to Erlotinib via anti-inflammatory, endogenous antioxidant responses and apoptotic gene activation.
Author: Lim, Swee-Ling|Mustapha, Noordin M|Goh, Yong-Meng|Bakar, Nurul Ain Abu|Mohamed, Suhaila
PMID: 27106908
Journal: Eur J Pharmacol. 2016 Jul 15;783:92-102.
Title: Isorhamnetin attenuates liver fibrosis by inhibiting TGF-beta/Smad signaling and relieving oxidative stress.
Author: Yang, Ji Hye|Kim, Sang Chan|Kim, Kyu Min|Jang, Chang Ho|Cho, Sam Seok|Kim, Seung Jung|Ku, Sae Kwang|Cho, Il Je|Ki, Sung Hwan
PMID: 27151496
Journal: Mol Cancer. 2016 May 16;15(1):38.
Title: Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib.
Author: Houessinon, Aline|Francois, Catherine|Sauzay, Chloe|Louandre, Christophe|Mongelard, Gaelle|Godin, Corinne|Bodeau, Sandra|Takahashi, Shinichiro|Saidak, Zuzana|Gutierrez, Laurent|Regimbeau, Jean-Marc|Barget, Nathalie|Barbare, Jean-Claude|Ganne, Nathalie|Cha
PMID: 27184800
Journal: Carcinogenesis. 2016 Jun;37(6):541-6.
Title: Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2.
Author: Karin, Michael|Dhar, Debanjan
PMID: 27207669
Journal: Cancer Cell. 2016 Jun 13;29(6):935-948.
Title: p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.
Author: Umemura, Atsushi|He, Feng|Taniguchi, Koji|Nakagawa, Hayato|Yamachika, Shinichiro|Font-Burgada, Joan|Zhong, Zhenyu|Subramaniam, Shankar|Raghunandan, Sindhu|Duran, Angeles|Linares, Juan F|Reina-Campos, Miguel|Umemura, Shiori|Valasek, Mark A|Seki, Ekihiro|Ya
PMID: 27211490
Journal: Int J Mol Sci. 2016 May 19;17(5). pii: ijms17050775.
Title: Ruthenium Complexes Induce HepG2 Human Hepatocellular Carcinoma Cell Apoptosis and Inhibit Cell Migration and Invasion through Regulation of the Nrf2 Pathway.
Author: Lu, Yiyu|Shen, Ting|Yang, Hua|Gu, Weiguang
PMID: 27213353
Journal: J Hepatobiliary Pancreat Sci. 2016 Aug;23(8):467-71.
Title: Accumulation of phosphorylated p62 is associated with NF-E2-related factor 2 activation in hepatocellular carcinoma.
Author: Shimizu, Takayuki|Inoue, Ken-Ichi|Hachiya, Hiroyuki|Shibuya, Norisuke|Aoki, Taku|Kubota, Keiichi
PMID: 27246794
Journal: Nat Commun. 2016 Jun 27;7:12030.
Title: p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.
Author: Saito, Tetsuya|Ichimura, Yoshinobu|Taguchi, Keiko|Suzuki, Takafumi|Mizushima, Tsunehiro|Takagi, Kenji|Hirose, Yuki|Nagahashi, Masayuki|Iso, Tetsuro|Fukutomi, Toshiaki|Ohishi, Maki|Endo, Keiko|Uemura, Takefumi|Nishito, Yasumasa|Okuda, Shujiro|Obata, Miki|K
PMID: 27345495
Journal: FEBS Lett. 2016 Aug;590(15):2375-97.
Title: p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer.
Author: Taniguchi, Koji|Yamachika, Shinichiro|He, Feng|Karin, Michael
PMID: 27404485
Journal: Am J Transl Res. 2016 Jul 15;8(7):2992-3002. eCollection 2016.
Title: miR-144 reverses chemoresistance of hepatocellular carcinoma cell lines by targeting Nrf2-dependent antioxidant pathway.
Author: Zhou, Suna|Ye, Wenguang|Zhang, Yanjun|Yu, Dequan|Shao, Qiuju|Liang, Jun|Zhang, Mingxin
PMID: 27508019
Journal: Oncotarget. 2016 Oct 18;7(42):68044-68056.
Title: Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis.
Author: Han, Bing|Shin, Hye-Jun|Bak, In Seon|Bak, Yesol|Jeong, Ye-Lin|Kwon, Taeho|Park, Young-Ho|Sun, Hu-Nan|Kim, Cheol-Hee|Yu, Dae-Yeul
PMID: 27517622
Journal: PLoS One. 2016 Aug 15;11(8):e0161083.
Title: p62/Sequestosome-1 Is Indispensable for Maturation and Stabilization of Mallory-Denk Bodies.
Author: Lahiri, Pooja|Schmidt, Volker|Smole, Claudia|Kufferath, Iris|Denk, Helmut|Strnad, Pavel|Rulicke, Thomas|Frohlich, Leopold F|Zatloukal, Kurt
PMID: 27526095
Journal: Food Chem Toxicol. 2016 Oct;96:280-9.
Title: Dietary zinc deficiency predisposes mice to the development of preneoplastic lesions in chemically-induced hepatocarcinogenesis.
Author: Romualdo, Guilherme Ribeiro|Goto, Renata Leme|Henrique Fernandes, Ana Angelica|Cogliati, Bruno|Barbisan, Luis Fernando
PMID: 27544374
Journal: Oncotarget. 2016 Oct 4;7(40):65389-65402.
Title: Activation of AKT pathway by Nrf2/PDGFA feedback loop contributes to HCC progression.
Author: Liu, Danyang|Zhang, Yonglong|Wei, Yingze|Liu, Guoyuan|Liu, Yufeng|Gao, Qiongmei|Zou, Liping|Zeng, Wenjiao|Zhang, Nong
PMID: 27588483
Journal: PLoS One. 2016 Sep 13;11(9):e0162397.
Title: Benzylglucosinolate Derived Isothiocyanate from Tropaeolum majus Reduces Gluconeogenic Gene and Protein Expression in Human Cells.
Author: Guzman-Perez, Valentina|Bumke-Vogt, Christiane|Schreiner, Monika|Mewis, Inga|Borchert, Andrea|Pfeiffer, Andreas F H
PMID: 27622707
Journal: Cancer Med. 2016 Oct;5(10):2678-2687.
Title: Clinical implication of Keap1 and phosphorylated Nrf2 expression in hepatocellular carcinoma.
Author: Chen, Jiang|Yu, Yaojun|Ji, Tong|Ma, Rui|Chen, Mingming|Li, Gaofeng|Li, Feibo|Ding, Qiong|Kang, Qingsong|Huang, Diyu|Liang, Xiao|Lin, Hui|Cai, Xiujun
PMID: 27650414
Journal: Toxicology. 2016 Dec 12;373:30-40.
Title: Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse.
Author: Hanna, Daniel|Riedmaier, Ariane Emami|Sugamori, Kim S|Grant, Denis M
PMID: 27746196
Journal: Curr Mol Med. 2016;16(9):820-828.
Title: Indazolo[3,2-b]quinazolinones Attack Hepatocellular Carcinoma Hep3B Cells by Inducing Mitochondrial-Dependent Apoptosis and Inhibition of Nrf2/ARE Signaling Pathway.
Author: Zhang, Y|Qiao, R|He, D|Zhao, Z|Yang, S|Zou, H|Zhang, X|Wu, M|Chen, J|Chen, P
PMID: 27894242
Journal: Pharmaceutics. 2016 Dec 28;9(1). pii: pharmaceutics9010003.
Title: Drug Transporter Expression and Activity in Human Hepatoma HuH-7 Cells.
Author: Jouan, Elodie|Le Vee, Marc|Denizot, Claire|Parmentier, Yannick|Fardel, Olivier
PMID: 28036031
Journal: J Pharmacol Sci. 2016 Oct;132(2):122-130.
Title: Calf Spleen Extractive Injection (CSEI), a small peptides enriched extraction, induces human hepatocellular carcinoma cell apoptosis via ROS/MAPKs dependent mitochondrial pathway.
Author: Jia, Dongxu|Lu, Wenqian|Zhang, Xinrui|Cai, Guangsheng|Teng, Lirong|Wang, Xinyu|Zhang, Minghai|Zeng, Yan|Liang, Chunhua|Wang, Di
PMID: 28314430
Journal: Protoplasma. 2017 Mar;254(2):911-920.
Title: Ductular reaction, cytokeratin 7 positivity, and gamma-glutamyl transferase in multistage hepatocarcinogenesis in rats.
Author: Moreira, Andrea Janz|Rodrigues, Graziella Ramos|Bona, Silvia|Fratta, Leila Xavier Sinigaglia|Weber, Giovana Regina|Picada, Jaqueline Nascimento|Dos Santos, Jorge Luiz|Cerski, Carlos Thadeu|Marroni, Claudio Augusto|Marroni, Norma Possa
PMID: 27525410
Journal: Free Radic Biol Med. 2017 Jan;102:87-99.
Title: Ptgr1 expression is regulated by NRF2 in rat hepatocarcinogenesis and promotes cell proliferation and resistance to oxidative stress.
Author: Sanchez-Rodriguez, Ricardo|Torres-Mena, Julia Esperanza|Quintanar-Jurado, Valeria|Chagoya-Hazas, Victoria|Rojas Del Castillo, Emilio|Del Pozo Yauner, Luis|Villa-Trevino, Saul|Perez-Carreon, Julio Isael
PMID: 27867096
Journal: Redox Biol. 2017 Apr;11:157-169.
Title: Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis.
Author: Duarte, Tiago L|Caldas, Carolina|Santos, Ana G|Silva-Gomes, Sandro|Santos-Goncalves, Andreia|Martins, Maria Joao|Porto, Graca|Lopes, Jose Manuel
PMID: 27936457
Journal: Int J Mol Sci. 2017 Feb 17;18(2). pii: ijms18020434.
Title: Proteome Characteristics of Non-Alcoholic Steatohepatitis Liver Tissue and Associated Hepatocellular Carcinomas.
Author: Kakehashi, Anna|Stefanov, Vasily E|Ishii, Naomi|Okuno, Takahiro|Fujii, Hideki|Kawai, Kazuaki|Kawada, Norifumi|Wanibuchi, Hideki
PMID: 28218651
Journal: Med Oncol. 2017 Apr;34(4):57.
Title: Oxidative stress indicated by elevated expression of Nrf2 and 8-OHdG promotes hepatocellular carcinoma progression.
Author: Ma-On, Chakriwong|Sanpavat, Anapat|Whongsiri, Patcharawalai|Suwannasin, Surasit|Hirankarn, Nattiya|Tangkijvanich, Pisit|Boonla, Chanchai
PMID: 28281193
Journal: Evid Based Complement Alternat Med. 2017;2017:7359806.
Title: Rosemary Extracts Upregulate Nrf2, Sestrin2, and MRP2 Protein Level in Human Hepatoma HepG2 Cells.
Author: Tong, Xiao-Pei|Ma, Yan-Xia|Quan, Dan-Ni|Zhang, Ling|Yan, Miao|Fan, Xin-Rong
PMID: 28286534
Journal: Free Radic Biol Med. 2017 Jul;108:66-76.
Title: Protective effects of coffee against oxidative stress induced by the tobacco carcinogen benzo[alpha]pyrene.
Author: Kalthoff, Sandra|Landerer, Steffen|Reich, Julia|Strassburg, Christian P
PMID: 28300668
Journal: Food Nutr Res. 2017 Jan 31;61(1):1271527.
Title: The role of plant processing for the cancer preventive potential of Ethiopian kale (Brassica carinata).
Author: Odongo, Grace Akinyi|Schlotz, Nina|Herz, Corinna|Hanschen, Franziska S|Baldermann, Susanne|Neugart, Susanne|Trierweiler, Bernhard|Frommherz, Lara|Franz, Charles M A P|Ngwene, Benard|Luvonga, Abraham Wahid|Schreiner, Monika|Rohn, Sascha|Lamy, Evelyn
PMID: 28326001
Journal: J Clin Invest. 2017 May 1;127(5):1856-1872.
Title: Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma.
Author: Lee, Derek|Xu, Iris Ming-Jing|Chiu, David Kung-Chun|Lai, Robin Kit-Ho|Tse, Aki Pui-Wah|Lan Li, Lynna|Law, Cheuk-Ting|Tsang, Felice Ho-Ching|Wei, Larry Lai|Chan, Cerise Yuen-Ki|Wong, Chun-Ming|Ng, Irene Oi-Lin|Wong, Carmen Chak-Lui
PMID: 28394261
Journal: J Biochem Mol Toxicol. 2017 Aug;31(8).
Title: Naringin abates adverse effects of cadmium-mediated hepatotoxicity: An experimental study using HepG2 cells.
Author: Rathi, Visesh Kumar|Das, Shubhankar|Parampalli Raghavendra, Archana|Rao, Bola Sadashiva Satish
PMID: 28422390
Journal: Sci Rep. 2017 May 23;7(1):2275.
Title: Athyrium multidentatum (Doll.) Ching extract induce apoptosis via mitochondrial dysfunction and oxidative stress in HepG2 cells.
Author: Qi, Guoyuan|Liu, Zhigang|Fan, Rong|Yin, Ziru|Mi, Yashi|Ren, Bo|Liu, Xuebo
PMID: 28536473
Journal: Mol Med Rep. 2017 Jul;16(1):597-602.
Title: Nrf2 mediates the protective effects of homocysteine by increasing the levels of GSH content in HepG2 cells.
Author: Zhang, Bing|Dong, Jing-Lin|Chen, Ying-Li|Liu, Yang|Huang, Shi-Shun|Zhong, Xiu-Li|Cheng, Yu-Hong|Wang, Zhi-Gang
PMID: 28560453
Journal: Int J Oncol. 2017 Aug;51(2):545-554.
Title: The Wnt inhibitor LGK-974 enhances radiosensitivity of HepG2 cells by modulating Nrf2 signaling.
Author: Tian, Dan|Shi, Ying|Chen, Dexi|Liu, Qiang|Fan, Feiyue
PMID: 28627706
Journal: Cancer Res. 2017 Sep 15;77(18):4797-4808.
Title: Nrf2 Mutagenic Activation Drives Hepatocarcinogenesis.
Author: Ngo, Hoang Kieu Chi|Kim, Do-Hee|Cha, Young-Nam|Na, Hye-Kyung|Surh, Young-Joon
PMID: 28655791
Journal: Evid Based Complement Alternat Med. 2017;2017:8231358.
Title: Antihepatocarcinoma Effect of Portulaca oleracea L. in Mice by PI3K/Akt/mTOR and Nrf2/HO-1/NF-kappaB Pathway.
Author: Guoyin, Zheng|Hao, Peng|Min, Li|Wei, Gu|Zhe, Chen|Changquan, Ling
PMID: 28659990
Journal: Adv Exp Med Biol. 2017;959:49-64.
Title: Molecular Pathogenesis of Liver Injury in Hereditary Tyrosinemia 1.
Author: Tanguay, Robert M|Angileri, Francesca|Vogel, Arndt
PMID: 28755183
Journal: Oxid Med Cell Longev. 2017;2017:8541064.
Title: Progression of Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital.
Author: Kakehashi, Anna|Ishii, Naomi|Okuno, Takahiro|Fujioka, Masaki|Gi, Min|Fukushima, Shoji|Wanibuchi, Hideki
PMID: 28785378
Journal: Sci Rep. 2017 Aug 23;7(1):9223.
Title: Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture.
Author: Aydin, Yucel|Chedid, Milad|Chava, Srinivas|Danielle Williams, Donkita|Liu, Shuanghu|Hagedorn, Curt H|Sumitran-Holgersson, Suchitra|Reiss, Krzysztof|Moroz, Krzysztof|Lu, Hua|Balart, Luis A|Dash, Srikanta
PMID: 28835697
Journal: Br J Cancer. 2017 Nov 7;117(10):1495-1506.
Title: Camptothecin suppresses NRF2-ARE activity and sensitises hepatocellular carcinoma cells to anticancer drugs.
Author: Chen, Feng|Wang, Huihui|Zhu, Jiayu|Zhao, Rui|Xue, Peng|Zhang, Qiang|Bud Nelson, M|Qu, Weidong|Feng, Bo|Pi, Jingbo
PMID: 28910823
Journal: Cancer Med. 2017 Oct;6(10):2357-2369.
Title: Expression of P62 in hepatocellular carcinoma involving hepatitis B virus infection and aflatoxin B1 exposure.
Author: Xiang, Xiao|Qin, Hong-Gui|You, Xue-Mei|Wang, Yan-Yan|Qi, Lu-Nan|Ma, Liang|Xiang, Bang-De|Zhong, Jian-Hong|Li, Le-Qun
PMID: 28941211
Journal: Cancer Res. 2017 Nov 15;77(22):6215-6225.
Title: FGF19 Protects Hepatocellular Carcinoma Cells against Endoplasmic Reticulum Stress via Activation of FGFR4-GSK3beta-Nrf2 Signaling.
Author: Teng, Yong|Zhao, Huakan|Gao, Lixia|Zhang, Wenfa|Shull, Austin Y|Shay, Chloe
PMID: 28951455
Journal: Biomed Pharmacother. 2017 Nov;95:1868-1875.
Title: Anti-hepatocarcinoma effect of cordycepin against NDEA-induced hepatocellular carcinomas via the PI3K/Akt/mTOR and Nrf2/HO-1/NF-kappaB pathway in mice.
Author: Zeng, Yongming|Lian, Shuyi|Li, Danfeng|Lin, Xiaosheng|Chen, Bozan|Wei, Hongfa|Yang, Tian
PMID: 28968944
Journal: Front Microbiol. 2017 Sep 28;8:1833.
Title: Long Non-coding RNAs in Hepatitis C Virus-Infected Cells.
Author: Barriocanal, Marina|Fortes, Puri
PMID: 29033906
Journal: Sci Rep. 2017 Nov 8;7(1):14986.
Title: Valproic Acid Sensitizes Hepatocellular Carcinoma Cells to Proton Therapy by Suppressing NRF2 Activation.
Author: Yu, Jeong Il|Choi, Changhoon|Shin, Sung-Won|Son, Arang|Lee, Ga-Haeng|Kim, Shin-Yeong|Park, Hee Chul
PMID: 29118323
Journal: Oncotarget. 2017 May 30;8(47):82085-82091.
Title: Apigenin sensitizes BEL-7402/ADM cells to doxorubicin through inhibiting miR-101/Nrf2 pathway.
Author: Gao, Ai-Mei|Zhang, Xiao-Yu|Ke, Zun-Ping
PMID: 29137246
Journal: Biomed Pharmacother. 2017 Dec;96:1283-1291.
Title: A composition of medicinal plants with an enhanced ability to suppress microsomal lipid peroxidation and a protective activity against carbon tetrachloride-induced hepatotoxicity.
Author: Aralbaeva, Araylim N|Mamataeva, Aigul T|Zhaparkulova, Nazgul I|Utegalieva, Raisa S|Khanin, Marina|Danilenko, Michael|Murzakhmetova, Maira K
PMID: 29169731
Journal: Front Pharmacol. 2017 Nov 27;8:868.
Title: Pelargonidin Modulates Keap1/Nrf2 Pathway Gene Expression and Ameliorates Citrinin-Induced Oxidative Stress in HepG2 Cells.
Author: Sharath Babu, G R|Anand, Tamatam|Ilaiyaraja, N|Khanum, Farhath|Gopalan, N
PMID: 29230174
Journal: Mol Med Rep. 2018 Jan;17(1):1907-1912.
Title: Protective effects of oxymatrine against lipopolysaccharide/Dgalactosamineinduced acute liver failure through oxidative damage, via activation of Nrf2/HO1 and modulation of inflammatory TLR4signaling pathways.
Author: Xu, Jian|Li, Chengmin|Li, Ziwei|Yang, Chan|Lei, Lan|Ren, Wei|Su, Yan|Chen, Chunping
PMID: 29138821
Journal: Chem Biol Interact. 2018 Jan 25;280:70-76.
Title: Regulation and role of nuclear factor-E2-related factor 2 (Nrf2) in multidrug resistance of hepatocellular carcinoma.
Author: Tian, Bing|Lu, Zhen-Ning|Guo, Xiu-Li
PMID: 29223570
Journal: Biochem Biophys Res Commun. 2018 Jan 8;495(2):1775-1781.
Title: Hepatocyte-specific clusterin overexpression attenuates diet-induced nonalcoholic steatohepatitis.
Author: Park, Jin-Sung|Shim, Young-Jun|Kang, Byeong-Ho|Lee, Woon-Kyu|Min, Bon-Hong
PMID: 29229391
Journal: Transl Res. 2018 Mar;193:54-71.
Title: Nrf2-p62 autophagy pathway and its response to oxidative stress in hepatocellular carcinoma.
Author: Bartolini, Desiree|Dallaglio, Katiuscia|Torquato, Pierangelo|Piroddi, Marta|Galli, Francesco
PMID: 29274776
Journal: Sci Rep. 2018 Jan 18;8(1):1084.
Title: Anti-cancer activities of allyl isothiocyanate and its conjugated silicon quantum dots.
Author: Liu, Peng|Behray, Mehrnaz|Wang, Qi|Wang, Wei|Zhou, Zhigang|Chao, Yimin|Bao, Yongping
PMID: 29348534
Journal: Pharmacol Ther. 2018 Jun;186:138-151.
Title: CCRK is a novel signalling hub exploitable in cancer immunotherapy.
Author: Mok, Myth T|Zhou, Jingying|Tang, Wenshu|Zeng, Xuezhen|Oliver, Antony W|Ward, Simon E|Cheng, Alfred S
PMID: 29360538
Journal: Dig Dis Sci. 2018 Apr;63(4):934-944.
Title: Aldo-Keto Reductases as Early Biomarkers of Hepatocellular Carcinoma: A Comparison Between Animal Models and Human HCC.
Author: Torres-Mena, Julia Esperanza|Salazar-Villegas, Karla Noemi|Sanchez-Rodriguez, Ricardo|Lopez-Gabino, Belem|Del Pozo-Yauner, Luis|Arellanes-Robledo, Jaime|Villa-Trevino, Saul|Gutierrez-Nava, Maria Angelica|Perez-Carreon, Julio Isael
PMID: 29383608
Journal: Life Sci. 2018 Apr 15;199:23-33.
Title: Isoniazid induces apoptosis: Role of oxidative stress and inhibition of nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2).
Author: Verma, Ajeet Kumar|Yadav, Arti|Singh, Sarvendra Vikram|Mishra, Pratibha|Rath, Srikanta Kumar
PMID: 29499281
Journal: Sci Rep. 2018 Mar 5;8(1):3999.
Title: Exposure of kale root to NaCl and Na2SeO3 increases isothiocyanate levels and Nrf2 signalling without reducing plant root growth.
Author: Kim, Sun Young|Park, Jai-Eok|Kim, Eun Ok|Lim, Sue Ji|Nam, Eui Jeong|Yun, Ji Ho|Yoo, GyHye|Oh, Sang-Rok|Kim, Hyoung Seok|Nho, Chu Won
PMID: 29507323
Journal: Arch Toxicol. 2018 Jun;92(6):2109-2118.
Title: Dysregulation of autophagy in rat liver with mitochondrial DNA depletion induced by the nucleoside analogue zidovudine.
Author: Santos-Llamas, Ana|Monte, Maria J|Marin, Jose J G|Perez, Maria J
PMID: 29594326
Journal: Nutrients. 2018 May 9;10(5). pii: nu10050585.
Title: Chemopreventive Activities of Sulforaphane and Its Metabolites in Human Hepatoma HepG2 Cells.
Author: Liu, Peng|Wang, Wei|Zhou, Zhigang|Smith, Andrew J O|Bowater, Richard P|Wormstone, Ian Michael|Chen, Yuqiong|Bao, Yongping
PMID: 29747418
Journal: J Hepatol. 2018 Sep;69(3):635-643.
Title: Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis.
Author: Orru, Claudia|Szydlowska, Marta|Taguchi, Keiko|Zavattari, Patrizia|Perra, Andrea|Yamamoto, Masayuki|Columbano, Amedeo
PMID: 29758334
Journal: Transl Gastroenterol Hepatol. 2018 Apr 23;3:20.
Title: SUMOylation and phosphorylation cross-talk in hepatocellular carcinoma.
Author: Tomasi, Maria Lauda|Ramani, Komal
PMID: 29780898
Journal: BMC Cancer. 2018 Jun 25;18(1):680.
Title: Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells.
Author: Murakami, Yuko|Sugiyama, Kazuo|Ebinuma, Hirotoshi|Nakamoto, Nobuhiro|Ojiro, Keisuke|Chu, Po-Sung|Taniki, Nobuhito|Saito, Yoshimasa|Teratani, Toshiaki|Koda, Yuzo|Suzuki, Takahiro|Saito, Kyoko|Fukasawa, Masayoshi|Ikeda, Masanori|Kato, Nobuyuki|Kanai, Takano
PMID: 29940898
Journal: J Cell Commun Signal. 2018 Jul 20. pii: 10.1007/s12079-018-0479-x.
Title: NRAL mediates cisplatin resistance in hepatocellular carcinoma via miR-340-5p/Nrf2 axis.
Author: Wu, Li-Li|Cai, Wen-Pin|Lei, Xin|Shi, Ke-Qing|Lin, Xiang-Yang|Shi, Liang
PMID: 30030687
Journal: Chem Biol Interact. 2018 Sep 25;293:61-69.
Title: Indolyl-chalcone derivatives induce hepatocellular carcinoma cells apoptosis through oxidative stress related mitochondrial pathway in vitro and in vivo.
Author: Zhang, Xinrui|Wang, Mengya|Teng, Shanshan|Wang, Di|Li, Xin|Wang, Xiaofeng|Liao, Weiwei|Wang, Di
PMID: 30055129
Journal: Yakugaku Zasshi. 2018;138(8):1059-1065.
Title: [Hit-to-Lead in Academia: Discovery of a Protein-Protein Interaction Inhibitor of Keap1-Nrf2].
Author: Yasuda, Daisuke|Obata, Rika|Takahashi, Kyoko|Ohe, Tomoyuki|Mashino, Tadahiko
PMID: 30068847
Journal: Am J Pathol. 2018 Oct;188(10):2339-2355.
Title: Chaperone-Mediated Autophagy Promotes Beclin1 Degradation in Persistently Infected Hepatitis C Virus Cell Culture.
Author: Aydin, Yucel|Stephens, Christopher M|Chava, Srinivas|Heidari, Zahra|Panigrahi, Rajesh|Williams, Donkita D|Wiltz, Kylar|Bell, Antoinette|Wilson, Wallace|Reiss, Krzysztof|Dash, Srikanta
PMID: 30075149
Journal: Cell Commun Signal. 2018 Aug 17;16(1):47.
Title: lncRNA KRAL reverses 5-fluorouracil resistance in hepatocellular carcinoma cells by acting as a ceRNA against miR-141.
Author: Wu, Lili|Pan, Chenwei|Wei, Xin|Shi, Yifen|Zheng, Jianjian|Lin, Xiangyang|Shi, Liang
PMID: 30119680
Journal: Int J Mol Sci. 2018 Aug 29;19(9). pii: ijms19092563.
Title: Effects of Antioxidants in Reducing Accumulation of Fat in Hepatocyte.
Author: Yang, Jung-Pyo|Shin, Ji-Hun|Seo, Seung-Hwan|Kim, Sang-Gyun|Lee, Sang Hyung|Shin, Eun-Hee
PMID: 30158441
Journal: Toxicol Appl Pharmacol. 2018 Oct 15;357:62-69.
Title: Nrf2 in alcoholic liver disease.
Author: Sun, Jing|Fu, Jingqi|Li, Lu|Chen, Chengjie|Wang, Huihui|Hou, Yongyong|Xu, Yuanyuan|Pi, Jingbo
PMID: 30165058
Journal: Evid Based Complement Alternat Med. 2018 Aug 16;2018:1549805.
Title: Cytotoxic Effect of Thymoquinone-Loaded Nanostructured Lipid Carrier (TQ-NLC) on Liver Cancer Cell Integrated with Hepatitis B Genome, Hep3B.
Author: Haron, Aminah Suhaila|Syed Alwi, Sharifah Sakinah|Saiful Yazan, Latifah|Abd Razak, Rohaina|Ong, Yong Sze|Zakarial Ansar, Fatin Hannani|Roshini Alexander, Henna
PMID: 30186351
Journal: Toxicol Appl Pharmacol. 2018 Sep 6;358:1-9.
Title: Triptolide enhances chemotherapeutic efficacy of antitumor drugs in non-small-cell lung cancer cells by inhibiting Nrf2-ARE activity.
Author: Zhu, Jiayu|Wang, Huihui|Chen, Feng|Lv, Hang|Xu, Zijin|Fu, Jingqi|Hou, Yongyong|Xu, Yuanyuan|Pi, Jingbo
PMID: 30196066
Journal: Can J Physiol Pharmacol. 2018 Sep 11.
Title: Vitamin D potentiates anti-tumor activity of 5-fluorouracil via modulating caspase-3 and TGF-beta1 expression in hepatocellular carcinoma-induced in rats.
Author: R Ebrahim, Amal|El-Mesery, Mohamed|El-Karef, Amro|Eissa, Laila Ahmed
PMID: 30205014
Journal: Int J Mol Sci. 2018 Sep 13;19(9). pii: ijms19092745.
Title: Molecular Mechanisms Involved in Oxidative Stress-Associated Liver Injury Induced by Chinese Herbal Medicine: An Experimental Evidence-Based Literature Review and Network Pharmacology Study.
Author: Zhang, Cheng|Wang, Ning|Xu, Yu|Tan, Hor-Yue|Li, Sha|Feng, Yibin
PMID: 30217028
Journal: J Ethnopharmacol. 2018 Sep 19;228:82-91.
Title: Astragali radix and its main bioactive compounds activate the Nrf2-mediated signaling pathway to induce P-glycoprotein and breast cancer resistance protein.
Author: Lou, Yanmei|Guo, Zhenzhen|Zhu, Yuanfeng|Zhang, Guiyu|Wang, Ying|Qi, Xiaoxiao|Lu, Linlin|Liu, Zhongqiu|Wu, Jinjun
PMID: 30243825
Journal: J Pharm Pharmacol. 2018 Sep 25.
Title: Benzyl sulforaphane is superior to sulforaphane in inhibiting the Akt/MAPK and activating the Nrf2/ARE signalling pathways in HepG2 cells.
Author: Ren, Jie|Yuan, Ling|Wang, Yue|Chen, Guangtong|Hu, Kun
PMID: 30251384
Journal: J Clin Biochem Nutr. 2018 Sep;63(2):123-128.
Title: Nrf2-mediated anti-oxidant effects contribute to suppression of non-alcoholic steatohepatitis-associated hepatocellular carcinoma in murine model.
Author: Yamada, Shoji|Kimura, Masaki|Saito, Yoshimasa|Saito, Hidetsugu
PMID: 30279623
Journal: Exp Mol Pathol. 2018 Oct 2;105(3):334-344.
Title: Rapamycin induces the expression of heme oxygenase-1 and peroxyredoxin-1 in normal hepatocytes but not in tumorigenic liver cells.
Author: Afroz, Farhana|Kist, Alwyn|Hua, Jin|Zhou, Yabin|Sokoya, Elke M|Padbury, Robert|Nieuwenhuijs, Vincent|Barritt, Greg
PMID: 30290159
Journal: Bioinformatics. 2018 Oct 25. pii: 5144669.
Title: A framework for identifying dysregulated chromatin regulators as master regulators in human cancer.
Author: Ru, Beibei|Sun, Jianlong|Kang, Qingzheng|Tong, Yin|Zhang, Jiangwen
PMID: 30358822