Primary Site >> Pancreatic Cancer

Gene >> MUC16

Journal: Am J Med Sci. 1986 Jul;292(1):30-4.
Title: Clinical significance of serum CA125 values in patients with cancers of the digestive system.
Author: Haga, Y|Sakamoto, K|Egami, H|Yoshimura, R|Mori, K|Akagi, M
PMID: 3459357
Journal: Gan To Kagaku Ryoho. 1988 Jul;15(7):2115-23.
Title: [Clinical evaluation on an enzyme immunoassay kit for basic fetoprotein (BFP). (2) Comparison and combination of BFP with other tumor markers].
Author: Ishii, M|Hattori, N|Kato, T|Mochizuki, M|Kamidono, S|Sawabu, N|Kawada, Y|Kawai, T|Abe, O|Ohkura, H
PMID: 2456040
Journal: Br J Cancer. 1988 Oct;58(4):505-6.
Title: Expression of CA125 in pancreatic carcinoma and chronic pancreatitis.
Author: Macdonald, F|Downing, R|Allum, W H
PMID: 3207606
Journal: Clin Biochem. 1989 Oct;22(5):363-8.
Title: Partial purification and characterization of CA19-9 antigen from the ascitic fluid of a patient with pancreatic cancer.
Author: Haga, Y|Horiuchi, S|Morino, Y|Akagi, M
PMID: 2805338
Journal: Scand J Clin Lab Invest Suppl. 1991;207:25-32.
Title: Evaluation of TATI and other markers in solid tumors.
Author: Taccone, W|Mazzon, W|Belli, M
PMID: 1780686
Journal: Rinsho Byori. 1994 Feb;42(2):139-42.
Title: [Early detection of pancreatic cancer by serum markers].
Author: Nakae, Y|Naruse, S|Shibata, T|Kitagawa, M|Kondo, T|Hayakawa, T|Kuno, N|Kurimoto, K
PMID: 7511183
Journal: Nihon Rinsho. 1996 Jun;54(6):1587-91.
Title: [Sensitivity and specificity of tumor markers in cancer diagnosis].
Author: Motoo, Y|Watanabe, H|Sawabu, N
PMID: 8691613
Journal: Yonsei Med J. 1996 Apr;37(2):131-41.
Title: Solid and papillary neoplasms of the pancreas.
Author: Lee, W J|Park, Y T|Choi, J S|Chi, H S|Kim, B R
PMID: 8711936
Journal: J Histochem Cytochem. 2001 Nov;49(11):1369-78.
Title: Immunocytochemical analysis of cell lines derived from solid tumors.
Author: Quentmeier, H|Osborn, M|Reinhardt, J|Zaborski, M|Drexler, H G
PMID: 11668190
Journal: Anticancer Drugs. 2008 Mar;19(3):295-302.
Title: An original administration of ifosfamide given once every other week: a clinical and pharmacological study.
Author: Cacheux, Wulfran|Gourmel, Bernard|Alexandre, Jerome|Germann, Nathalie|Rabillon, Florence|Duffau, Bertrand|Goldwasser, Francois
PMID: 18510176
Journal: Mol Cell Proteomics. 2009 Jul;8(7):1697-707.
Title: The prevalence and nature of glycan alterations on specific proteins in pancreatic cancer patients revealed using antibody-lectin sandwich arrays.
Author: Yue, Tingting|Goldstein, Irwin J|Hollingsworth, Michael A|Kaul, Karen|Brand, Randall E|Haab, Brian B
PMID: 19377061
Journal: Gan To Kagaku Ryoho. 2009 Jul;36(7):1191-4.
Title: [A resected case of effective treatment with S-1/gemcitabine and Paclitaxel combination chemotherapy for advanced pancreatic cancer with peritoneal and liver metastases].
Author: Kimura, Hironobu|Fushida, Sachio|Mukawa, Akio
PMID: 19620816
Journal: J Proteome Res. 2009 Apr;8(4):1876-86.
Title: Mucin glycosylation is altered by pro-inflammatory signaling in pancreatic-cancer cells.
Author: Wu, Yi-Mi|Nowack, D David|Omenn, Gilbert S|Haab, Brian B
PMID: 19714813
Journal: J Transl Med. 2009 Dec 11;7:105.
Title: Identification of a biomarker panel using a multiplex proximity ligation assay improves accuracy of pancreatic cancer diagnosis.
Author: Chang, Stephanie T|Zahn, Jacob M|Horecka, Joe|Kunz, Pamela L|Ford, James M|Fisher, George A|Le, Quynh T|Chang, Daniel T|Ji, Hanlee|Koong, Albert C
PMID: 20003342
Journal: BMJ Case Rep. 2009;2009. pii: bcr11.2008.1219.
Title: Markedly elevated CA19-9 associated with benign ovarian cyst and ascites.
Author: Brain, Oliver|Brown, Laura H W|Suvarna, Shaila|Chapman, Roger
PMID: 21686409
Journal: Ann Surg. 2010 May;251(5):937-45.
Title: Glycosylation variants of mucins and CEACAMs as candidate biomarkers for the diagnosis of pancreatic cystic neoplasms.
Author: Haab, Brian B|Porter, Andrew|Yue, Tingting|Li, Lin|Scheiman, James|Anderson, Michelle A|Barnes, Dawn|Schmidt, C Max|Feng, Ziding|Simeone, Diane M
PMID: 20395854
Journal: Int J Cancer. 2011 May 1;128(9):2020-30.
Title: A novel high-affinity human monoclonal antibody to mesothelin.
Author: Ho, Mitchell|Feng, Mingqian|Fisher, Robert J|Rader, Christoph|Pastan, Ira
PMID: 20635390
Journal: PLoS One. 2011;6(10):e26839.
Title: Pathobiological implications of MUC16 expression in pancreatic cancer.
Author: Haridas, Dhanya|Chakraborty, Subhankar|Ponnusamy, Moorthy P|Lakshmanan, Imayavaramban|Rachagani, Satyanarayana|Cruz, Eric|Kumar, Sushil|Das, Srustidhar|Lele, Subodh M|Anderson, Judy M|Wittel, Uwe A|Hollingsworth, Michael A|Batra, Surinder K
PMID: 22066010
Journal: PLoS One. 2011;6(12):e29180.
Title: Enhanced discrimination of malignant from benign pancreatic disease by measuring the CA 19-9 antigen on specific protein carriers.
Author: Yue, Tingting|Maupin, Kevin A|Fallon, Brian|Li, Lin|Partyka, Katie|Anderson, Michelle A|Brenner, Dean E|Kaul, Karen|Zeh, Herbert|Moser, A James|Simeone, Diane M|Feng, Ziding|Brand, Randall E|Haab, Brian B
PMID: 22220206
Journal: Cancer Biomark. 2011-2012;11(1):1-14.
Title: Differential gene expression analysis of peripheral blood mononuclear cells reveals novel test for early detection of pancreatic cancer.
Author: Baine, Michael J|Menning, Melanie|Smith, Lynette M|Mallya, Kavita|Kaur, Sukhwinder|Rachagani, Satyanarayana|Chakraborty, Subhankar|Sasson, Aaron R|Brand, Randall E|Batra, Surinder K
PMID: 22820136
Journal: FASEB J. 2012 Mar;26(3):1349-59.
Title: Mucin 16 is a functional selectin ligand on pancreatic cancer cells.
Author: Chen, Shih-Hsun|Dallas, Matthew R|Balzer, Eric M|Konstantopoulos, Konstantinos
PMID: 22159147
Journal: Cancer Sci. 2012 Apr;103(4):739-46.
Title: Coexpression of MUC16 and mesothelin is related to the invasion process in pancreatic ductal adenocarcinoma.
Author: Shimizu, Atsushi|Hirono, Seiko|Tani, Masaji|Kawai, Manabu|Okada, Ken-Ichi|Miyazawa, Motoki|Kitahata, Yuji|Nakamura, Yasushi|Noda, Tetsuo|Yokoyama, Shozo|Yamaue, Hiroki
PMID: 22320398
Journal: Curr Pharm Des. 2012;18(17):2472-81.
Title: Mucin-based targeted pancreatic cancer therapy.
Author: Torres, Maria P|Chakraborty, Subhankar|Souchek, Joshua|Batra, Surinder K
PMID: 22372499
Journal: Biotechnol Lett. 2012 Jul;34(7):1235-41.
Title: Changes in the expression of serum markers CA242, CA199, CA125, CEA, TNF-alpha and TSGF after cryosurgery in pancreatic cancer patients.
Author: Zhou, Gang|Niu, Lizhi|Chiu, David|He, Lihua|Xu, Kecheng
PMID: 22456901
Journal: Case Rep Med. 2012;2012:579297.
Title: Tuberculous lymphadenopathy mimicking pancreatic neoplasm.
Author: Hoshino, Kunikazu|Arakaki, Shingo|Shibata, Daisuke|Maeshiro, Tatsuji|Hokama, Akira|Kinjo, Fukunori|Shiraishi, Masayuki|Nishimaki, Tadashi|Fujita, Jiro
PMID: 22851977
Journal: Am J Surg Pathol. 2012 Nov;36(11):1647-55.
Title: Intraductal tubular neoplasms of the bile ducts.
Author: Katabi, Nora|Torres, Javiera|Klimstra, David S
PMID: 23073323
Journal: PLoS One. 2013 Oct 25;8(10):e73356.
Title: MicroRNA-200c modulates the expression of MUC4 and MUC16 by directly targeting their coding sequences in human pancreatic cancer.
Author: Radhakrishnan, Prakash|Mohr, Ashley M|Grandgenett, Paul M|Steele, Maria M|Batra, Surinder K|Hollingsworth, Michael A
PMID: 24204560
Journal: J Gastrointest Surg. 2013 Dec;17(12):2092-8.
Title: CA125 is superior to CA19-9 in predicting the resectability of pancreatic cancer.
Author: Luo, Guopei|Xiao, Zhiwen|Long, Jiang|Liu, Zuqiang|Liu, Liang|Liu, Chen|Xu, Jin|Ni, Quanxing|Yu, Xianjun
PMID: 24146342
Journal: Sci Rep. 2013;3:1870.
Title: Mesothelin binding to CA125/MUC16 promotes pancreatic cancer cell motility and invasion via MMP-7 activation.
Author: Chen, Shih-Hsun|Hung, Wei-Chien|Wang, Pu|Paul, Colin|Konstantopoulos, Konstantinos
PMID: 23694968
Journal: Anticancer Agents Med Chem. 2013 Feb;13(2):276-80.
Title: The role of mesothelin in tumor progression and targeted therapy.
Author: Tang, Zhewei|Qian, Min|Ho, Mitchell
PMID: 22721387
Journal: PLoS One. 2013 Sep 6;8(9):e72413.
Title: Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing.
Author: Madsen, Caroline B|Lavrsen, Kirstine|Steentoft, Catharina|Vester-Christensen, Malene B|Clausen, Henrik|Wandall, Hans H|Pedersen, Anders Elm
PMID: 24039759
Journal: Mol Clin Oncol. 2014 Mar;2(2):265-268.
Title: Clinical value of serum tumor markers CA19-9, CA125 and CA72-4 in the diagnosis of pancreatic carcinoma.
Author: Wang, Zi|Tian, Ya-Ping
PMID: 24649344
Journal: Chin Med J (Engl). 2014;127(10):1891-6.
Title: Diagnosis of pancreatic carcinoma based on combined measurement of multiple serum tumor markers using artificial neural network analysis.
Author: Yang, Yingchi|Chen, Hui|Wang, Dong|Luo, Wei|Zhu, Biyun|Zhang, Zhongtao
PMID: 24824251
Journal: Clin Cancer Res. 2014 Nov 15;20(22):5787-95.
Title: Validation of biomarkers that complement CA19.9 in detecting early pancreatic cancer.
Author: Chan, Alison|Prassas, Ioannis|Dimitromanolakis, Apostolos|Brand, Randall E|Serra, Stefano|Diamandis, Eleftherios P|Blasutig, Ivan M
PMID: 25239611
Journal: Oncotarget. 2015 Mar 20;6(8):5772-87.
Title: Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells.
Author: Das, Srustidhar|Rachagani, Satyanarayana|Torres-Gonzalez, Maria P|Lakshmanan, Imayavaramban|Majhi, Prabin D|Smith, Lynette M|Wagner, Kay-Uwe|Batra, Surinder K
PMID: 25691062
Journal: Oncotarget. 2015 Sep 22;6(28):24842-55.
Title: Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear flow.
Author: Shea, Daniel J|Wirtz, Denis|Stebe, Kathleen J|Konstantopoulos, Konstantinos
PMID: 26329844
Journal: Oncotarget. 2015 Aug 7;6(22):19118-31.
Title: MUC16-mediated activation of mTOR and c-Myc reprograms pancreatic cancer metabolism.
Author: Shukla, Surendra K|Gunda, Venugopal|Abrego, Jaime|Haridas, Dhanya|Mishra, Anusha|Souchek, Joshua|Chaika, Nina V|Yu, Fang|Sasson, Aaron R|Lazenby, Audrey J|Batra, Surinder K|Singh, Pankaj K
PMID: 26046375
Journal: Int J Mol Sci. 2015 Jan 29;16(2):2956-70.
Title: Expression and diagnostic value of HE4 in pancreatic adenocarcinoma.
Author: Huang, Tianhe|Jiang, Shi-Wen|Qin, Liangyi|Senkowski, Christopher|Lyle, Christian|Terry, Karen|Brower, Steven|Chen, Haibin|Glasgow, Wayne|Wei, Yongchang|Li, Jinping
PMID: 25642754
Journal: Cell Biochem Biophys. 2015 Apr;71(3):1287-91.
Title: Serum CA242, CA199, CA125, CEA, and TSGF are Biomarkers for the Efficacy and Prognosis of Cryoablation in Pancreatic Cancer Patients.
Author: Chen, Ye|Gao, She-Gan|Chen, Jian-Min|Wang, Gong-Ping|Wang, Zeng-Fang|Zhou, Bo|Jin, Can-Hui|Yang, Yan-Tong|Feng, Xiao-Shan
PMID: 25486903
Journal: Int J Biol Markers. 2015 Feb 24;30(1):e122-6.
Title: Dilution effect of serum CA125 and CA19-9 over a cutoff value, according to obesity.
Author: Kim, Jae Heon|Park, Bo Ra|Yang, Won Jae
PMID: 25262704
Journal: Int J Oncol. 2016 Mar;48(3):900-7.
Title: The clinical utility of CA125/MUC16 in pancreatic cancer: A consensus of diagnostic, prognostic and predictive updates by the Chinese Study Group for Pancreatic Cancer (CSPAC).
Author: Liu, Liang|Xiang, Jinfeng|Chen, Rufu|Fu, Deliang|Hong, Defei|Hao, Jihui|Li, Yixiong|Li, Jiangtao|Li, Shengping|Mou, Yiping|Mai, Gang|Ni, Quanxing|Peng, Li|Qin, Renyi|Qian, Honggang|Shao, Chenghao|Sun, Bei|Sun, Yongwei|Tao, Min|Tian, Bole|Wang, Hongxia|Wan
PMID: 26718269
Journal: Tumour Biol. 2016 Sep;37(9):12193-12202.
Title: DUSP28 links regulation of Mucin 5B and Mucin 16 to migration and survival of AsPC-1 human pancreatic cancer cells.
Author: Lee, Jungwhoi|Lee, Jungsul|Yun, Jeong-Hun|Jeong, Dae Gwin|Kim, Jae Hoon
PMID: 27230679
Journal: Gan To Kagaku Ryoho. 2016 Nov;43(12):1985-1987.
Title: [A Case of Early-Onset Rapidly Progressive Cerebral Infarction with Trousseau's Syndrome in a Patient with Pancreatic Cancer Undergoing Surgery].
Author: Yogi, Norikazu|Nojima, Hiroyuki|Shimizu, Hiroaki|Ohtsuka, Masayuki|Kato, Atsushi|Yoshitomi, Hideyuki|Furukawa, Katsunori|Takayashiki, Tsukasa|Takano, Shigetsugu|Kuboki, Satoshi|Suzuki, Daisuke|Sakai, Nozomu|Kagawa, Shingo|Miyazaki, Masaru
PMID: 28133197
Journal: Appl Immunohistochem Mol Morphol. 2017 Oct;25(9):620-623.
Title: Cancer Antigen 125 (CA125, MUC16) Protein Expression in the Diagnosis and Progression of Pancreatic Ductal Adenocarcinoma.
Author: Jiang, Kun|Tan, Elaine|Sayegh, Zena|Centeno, Barbara|Malafa, Mokenge|Coppola, Domenico
PMID: 27093451
Journal: Onco Targets Ther. 2017 Nov 8;10:5337-5353.
Title: Amatuximab and novel agents targeting mesothelin for solid tumors.
Author: Baldo, Paolo|Cecco, Sara
PMID: 29184420
Journal: Nature. 2017 Nov 23;551(7681):512-516.
Title: Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer.
Author: Balachandran, Vinod P|Luksza, Marta|Zhao, Julia N|Makarov, Vladimir|Moral, John Alec|Remark, Romain|Herbst, Brian|Askan, Gokce|Bhanot, Umesh|Senbabaoglu, Yasin|Wells, Daniel K|Cary, Charles Ian Ormsby|Grbovic-Huezo, Olivera|Attiyeh, Marc|Medina, Benjamin|
PMID: 29132146
Journal: Sci Rep. 2017 Mar 6;7:43927.
Title: Galectin-3 is a non-classic RNA binding protein that stabilizes the mucin MUC4 mRNA in the cytoplasm of cancer cells.
Author: Coppin, Lucie|Vincent, Audrey|Frenois, Frederic|Duchene, Belinda|Lahdaoui, Fatima|Stechly, Laurence|Renaud, Florence|Villenet, Celine|Van Seuningen, Isabelle|Leteurtre, Emmanuelle|Dion, Johann|Grandjean, Cyrille|Poirier, Francoise|Figeac, Martin|Delacour,
PMID: 28262838
Journal: Mol Cancer Res. 2017 Feb;15(2):201-212.
Title: Oncogenic KRAS Targets MUC16/CA125 in Pancreatic Ductal Adenocarcinoma.
Author: Liang, Chen|Qin, Yi|Zhang, Bo|Ji, Shunrong|Shi, Si|Xu, Wenyan|Liu, Jiang|Xiang, Jinfeng|Liang, Dingkong|Hu, Qiangsheng|Ni, Quanxing|Xu, Jin|Yu, Xianjun
PMID: 28108627
Journal: Cancer Biomark. 2018 Feb 14;21(3):505-511.
Title: Growth differentiation factor (GDF-15) concentration combined with Ca125 levels in serum is superior to commonly used cancer biomarkers in differentiation of pancreatic mass.
Author: Hogendorf, Piotr|Durczynski, Adam|Skulimowski, Aleksander|Kumor, Anna|Poznanska, Grazyna|Strzelczyk, Janusz
PMID: 29171983
Journal: Cancer Lett. 2018 Apr 1;418:167-175.
Title: MUC16 C terminal-induced secretion of tumor-derived IL-6 contributes to tumor-associated Treg enrichment in pancreatic cancer.
Author: Fan, Kun|Yang, Chao|Fan, Zhiyao|Huang, Qiuyi|Zhang, Yiyin|Cheng, He|Jin, Kaizhou|Lu, Yu|Wang, Zhengshi|Luo, Guopei|Yu, Xianjun|Liu, Chen
PMID: 29337110
Journal: Biochem Biophys Res Commun. 2018 Apr 30;499(1):37-43.
Title: Detection and proteomic characterization of extracellular vesicles in human pancreatic juice.
Author: Osteikoetxea, Xabier|Benke, Marton|Rodriguez, Marta|Paloczi, Krisztina|Sodar, Barbara W|Szvicsek, Zsuzsanna|Szabo-Taylor, Katalin|Vukman, Krisztina V|Kittel, Agnes|Wiener, Zoltan|Vekey, Karoly|Harsanyi, Laszlo|Szucs, Akos|Turiak, Lilla|Buzas, Edit I
PMID: 29550476
Journal: PLoS One. 2018 May 8;13(5):e0197029.
Title: Fn3 proteins engineered to recognize tumor biomarker mesothelin internalize upon binding.
Author: Sirois, Allison R|Deny, Daniela A|Baierl, Samantha R|George, Katia S|Moore, Sarah J
PMID: 29738555
Journal: Int J Mol Med. 2018 Aug;42(2):713-725.
Title: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review).
Author: Katoh, Masaru
PMID: 29786110
Journal: Biomark Cancer. 2018 May 30;10:1179299X18776974.
Title: Clean Colorectum at Diagnostic Colonoscopy: Subsequent Detection of Extracolonic Malignancies by Plasma Protein Biomarkers?
Author: Wilhelmsen, Michael|Christensen, Ib J|Jorgensen, Lars N|Madsen, Mogens R|Vilandt, Jesper|Hillig, Thore|Klaerke, Michael|Nielsen, Knud T|Laurberg, Soren|Gawel, Susan|Yang, Xiaoping|Davis, Gerard|Heijboer, Anne Meike|Martens, Frans|Nielsen, Hans J
PMID: 29872358
Journal: Int J Cancer. 2018 Jul 6.
Title: MiR-29a, targeting caveolin 2 expression, is responsible for limitation of pancreatic cancer metastasis in patients with normal level of serum CA125.
Author: Liang, Chen|Shi, Si|Meng, Qingcai|Liang, Dingkong|Hua, Jie|Qin, Yi|Zhang, Bo|Xu, Jin|Ni, Quanxing|Yu, Xianjun
PMID: 29978477
Journal: Zhonghua Wai Ke Za Zhi. 2018 Aug 1;56(8):591-596.
Title: [Diagnosis and treatment experience of 161 cases of pancreatic serous cystic neoplasm in single center and analysis of cause of preoperation misjudgement].
Author: Lin, K R|Zhu, J Q|Li, J|Gu, J C|Li, H C|Wei, R|Guo, Y|Wang, Y Y|Wang, H Y|Fu, D L
PMID: 30107701
Journal: J Transl Med. 2018 Sep 20;16(1):259.
Title: Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas.
Author: Jonckheere, Nicolas|Van Seuningen, Isabelle
PMID: 30236127
Journal: Toxins (Basel). 2018 Oct 31;10(11). pii: toxins10110447.
Title: Protein Synthesis Inhibition Activity of Mesothelin Targeting Immunotoxin LMB-100 Decreases Concentrations of Oncogenic Signaling Molecules and Secreted Growth Factors.
Author: El-Behaedi, Salma|Landsman, Rebekah|Rudloff, Michael|Kolyvas, Emily|Albalawy, Rakan|Zhang, Xianyu|Bera, Tapan|Collins, Keith|Kozlov, Serguei|Alewine, Christine
PMID: 30384408