Primary Site >> Pancreatic Cancer

Gene >> MAP2K7

1.
Journal: FEBS Lett. 1997 May 5;407(3):343-6.
Title: Activation of MAP kinase cascade induced by human pancreatic phospholipase A2 in a human pancreatic cancer cell line.
Author: Kinoshita, E|Handa, N|Hanada, K|Kajiyama, G|Sugiyama, M
PMID: 9175881
2.
Journal: Int J Oncol. 1999 Aug;15(2):271-9.
Title: Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression.
Author: Yip-Schneider, M T|Lin, A|Barnard, D|Sweeney, C J|Marshall, M S
PMID: 10402237
3.
Journal: Oncogene. 2000 Jun 8;19(25):2930-42.
Title: Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration.
Author: Giehl, K|Skripczynski, B|Mansard, A|Menke, A|Gierschik, P
PMID: 10871844
4.
Journal: J Cell Biochem. 2000 Sep 7;79(3):355-69.
Title: MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells.
Author: Boucher, M J|Morisset, J|Vachon, P H|Reed, J C|Laine, J|Rivard, N
PMID: 10972974
5.
Journal: Biochem Biophys Res Commun. 2001 Feb 2;280(4):992-7.
Title: Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2.
Author: Yip-Schneider, M T|Lin, A|Marshall, M S
PMID: 11162624
6.
Journal: Br J Cancer. 2001 Apr 6;84(7):926-35.
Title: Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions.
Author: Murphy, L O|Cluck, M W|Lovas, S|Otvos, F|Murphy, R F|Schally, A V|Permert, J|Larsson, J|Knezetic, J A|Adrian, T E
PMID: 11286473
7.
Journal: Cancer Res. 2001 May 15;61(10):4222-8.
Title: Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation.
Author: Ellenrieder, V|Hendler, S F|Boeck, W|Seufferlein, T|Menke, A|Ruhland, C|Adler, G|Gress, T M
PMID: 11358848
8.
Journal: Biochem Biophys Res Commun. 2001 Mar 30;282(2):447-53.
Title: MEK/ERK-mediated proliferation is negatively regulated by P38 map kinase in the human pancreatic cancer cell line, PANC-1.
Author: Ding, X Z|Adrian, T E
PMID: 11401480
9.
Journal: Int J Cancer. 2001 Dec 1;94(5):630-6.
Title: 12-lipoxygenase metabolite 12(S)-HETE stimulates human pancreatic cancer cell proliferation via protein tyrosine phosphorylation and ERK activation.
Author: Ding, X Z|Tong, W G|Adrian, T E
PMID: 11745456
10.
Journal: Mol Carcinog. 2002 Aug;34(4):180-6.
Title: Enhancement of anchorage-independent growth of human pancreatic carcinoma MIA PaCa-2 cells by signaling from protein kinase C to mitogen-activated protein kinase.
Author: Ishino, Keiko|Fukazawa, Hidesuke|Shikano, Mayumi|Ohba, Motoi|Kuroki, Toshio|Uehara, Yoshimasa
PMID: 12203369
11.
Journal: Int J Gastrointest Cancer. 2002;32(2-3):63-72.
Title: Activation of conventional PKC isoforms increases expression of the pro-apoptotic protein Bad and TRAIL receptors.
Author: Farrow, Buckminster|Thomas, Robert P|Wang, Xiao-fu|Evers, B Mark
PMID: 12794242
12.
Journal: Oncol Rep. 2003 Sep-Oct;10(5):1525-8.
Title: Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor.
Author: Matsui, Yoshifumi|Goto, Miyako|Iwakawa, Mayumi|Asano, Takehide|Kenmochi, Takashi|Imai, Takashi|Ochiai, Takenori
PMID: 12883735
13.
Journal: Pancreas. 2003 Nov;27(4):337-44.
Title: MEK inhibition of pancreatic carcinoma cells by U0126 and its effect in combination with sulindac.
Author: Yip-Schneider, Michele T|Schmidt, C Max
PMID: 14576498
14.
Journal: Clin Exp Metastasis. 2003;20(6):499-505.
Title: Growth factor-dependent activation of the MAPK pathway in human pancreatic cancer: MEK/ERK and p38 MAP kinase interaction in uPA synthesis.
Author: Lee, Kyung Hee|Hyun, Myung Soo|Kim, Jae-Ryong
PMID: 14598883
15.
Journal: Semin Oncol. 2003 Oct;30(5 Suppl 16):105-16.
Title: CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK).
Author: Allen, Lee F|Sebolt-Leopold, Judith|Meyer, Mark B
PMID: 14613031
16.
Journal: Oncology. 2003;65(4):285-94.
Title: Multiple signal pathways are involved in the mitogenic effect of 5(S)-HETE in human pancreatic cancer.
Author: Ding, Xian-Zhong|Tong, Wei-Gang|Adrian, Thomas E
PMID: 14707447
17.
Journal: Int J Oncol. 2004 Jan;24(1):65-73.
Title: Involvement of the mitogen-activated protein kinase kinase 2 in the induction of cell dissociation in pancreatic cancer.
Author: Tan, Xiaodong|Egami, Hiroshi|Kamohara, Hidenobu|Ishikawa, Shinji|Kurizaki, Takashi|Yoshida, Naoya|Tamori, Yasuhiko|Takai, Eiji|Hirota, Masahiko|Ogawa, Michio
PMID: 14654942
18.
Journal: Pancreas. 2004 Mar;28(2):153-9.
Title: Activation and role of MAP kinases in 15d-PGJ2-induced apoptosis in the human pancreatic cancer cell line MIA PaCa-2.
Author: Hashimoto, Koji|Farrow, Buckminster J|Evers, B Mark
PMID: 15028947
19.
Journal: Oncol Rep. 2004 May;11(5):993-8.
Title: Analysis of invasion-metastasis mechanism in pancreatic cancer: involvement of tight junction transmembrane protein occludin and MEK/ERK signal transduction pathway in cancer cell dissociation.
Author: Tan, Xiaodong|Tamori, Yasuhiro|Egami, Hiroshi|Ishikawa, Shinji|Kurizaki, Takashi|Takai, Eiji|Hirota, Masahiko|Ogawa, Michio
PMID: 15069537
20.
Journal: Clin Cancer Res. 2004 Apr 1;10(7):2299-306.
Title: Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine.
Author: Yokoi, Kenji|Fidler, Isaiah J
PMID: 15073105
21.
Journal: J Clin Oncol. 2004 Nov 15;22(22):4456-62.
Title: Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer.
Author: Rinehart, John|Adjei, Alex A|Lorusso, Patricia M|Waterhouse, David|Hecht, J Randolph|Natale, Ronald B|Hamid, Oday|Varterasian, Mary|Asbury, Peggy|Kaldjian, Eric P|Gulyas, Stephen|Mitchell, David Y|Herrera, Roman|Sebolt-Leopold, Judith S|Meyer, Mark B
PMID: 15483017
22.
Journal: Int J Oncol. 2004 Nov;25(5):1303-9.
Title: Relationship between activation of epidermal growth factor receptor and cell dissociation in pancreatic cancer.
Author: Tan, Xiaodong|Egami, Hiroshi|Ishikawa, Shinji|Nakagawa, Masahide|Ishiko, Takatoshi|Kamohara, Hidenobu|Hirota, Masahiko|Ogawa, Michio
PMID: 15492819
23.
Journal: Mol Cell Biol. 2004 Dec;24(24):10868-81.
Title: Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT.
Author: Mirza, Amer M|Gysin, Stephan|Malek, Nisar|Nakayama, Kei-ichi|Roberts, James M|McMahon, Martin
PMID: 15572689
24.
Journal: J Cell Physiol. 2005 Mar;202(3):880-90.
Title: Neurotensin and EGF induce synergistic stimulation of DNA synthesis by increasing the duration of ERK signaling in ductal pancreatic cancer cells.
Author: Kisfalvi, Krisztina|Guha, Sushovan|Rozengurt, Enrique
PMID: 15389644
25.
Journal: FASEB J. 2005 Apr;19(6):620-2. Epub 2005 Jan 24.
Title: CD95 and TRAF2 promote invasiveness of pancreatic cancer cells.
Author: Trauzold, Anna|Roder, Christian|Sipos, Bence|Karsten, Kristin|Arlt, Alexander|Jiang, Ping|Martin-Subero, Jose Ignacio|Siegmund, Daniela|Muerkoster, Susanne|Pagerols-Raluy, Laia|Siebert, Reiner|Wajant, Harald|Kalthoff, Holger
PMID: 15670977
26.
Journal: Int J Oncol. 2005 May;26(5):1283-9.
Title: Involvement of matrix metalloproteinase-7 in invasion-metastasis through induction of cell dissociation in pancreatic cancer.
Author: Tan, Xiaodong|Egami, Hiroshi|Ishikawa, Shinji|Sugita, Hideki|Kamohara, Hidenobu|Nakagawa, Masahide|Nozawa, Fumiaki|Abe, Michio|Ogawa, Michio
PMID: 15809719
27.
Journal: Biochem Biophys Res Commun. 2005 Jun 24;332(1):89-94.
Title: Involvement of MEK-ERK signaling pathway in the inhibition of cell growth by troglitazone in human pancreatic cancer cells.
Author: Motomura, Wataru|Tanno, Satoshi|Takahashi, Nobuhiko|Nagamine, Miho|Fukuda, Mitsuko|Kohgo, Yutaka|Okumura, Toshikatsu
PMID: 15896303
28.
Journal: J Clin Oncol. 2005 Aug 10;23(23):5281-93.
Title: Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies.
Author: Lorusso, Patricia M|Adjei, Alex A|Varterasian, Mary|Gadgeel, Shirish|Reid, Joel|Mitchell, David Y|Hanson, Lorelei|DeLuca, Pamela|Bruzek, Laura|Piens, Jill|Asbury, Peggy|Van Becelaere, Keri|Herrera, Roman|Sebolt-Leopold, Judith|Meyer, Mark B
PMID: 16009947
29.
Journal: Biochem Biophys Res Commun. 2005 Sep 30;335(3):949-56.
Title: LTB4 stimulates growth of human pancreatic cancer cells via MAPK and PI-3 kinase pathways.
Author: Tong, Wei-Gang|Ding, Xian-Zhong|Talamonti, Mark S|Bell, Richard H|Adrian, Thomas E
PMID: 16105664
30.
Journal: J Clin Pathol. 2005 Dec;58(12):1242-8.
Title: Involvement of MMP-7 in invasion of pancreatic cancer cells through activation of the EGFR mediated MEK-ERK signal transduction pathway.
Author: Tan, X|Egami, H|Abe, M|Nozawa, F|Hirota, M|Ogawa, M
PMID: 16311341
31.
Journal: Cell Signal. 2006 Aug;18(8):1156-68. Epub 2005 Oct 27.
Title: Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38.
Author: Dreissigacker, Ute|Mueller, Meike S|Unger, Monika|Siegert, Patrizia|Genze, Felicitas|Gierschik, Peter|Giehl, Klaudia
PMID: 16257181
32.
Journal: Int J Oncol. 2006 Jul;29(1):33-40.
Title: MUC5AC mucin gene regulation in pancreatic cancer cells.
Author: Kato, Shingo|Hokari, Ryota|Crawley, Suzanne|Gum, James|Ahn, Dae-Ho|Kim, Jong-Woo|Kwon, Sung-Won|Miura, Soichiro|Basbaum, Carol B|Kim, Young S
PMID: 16773182
33.
Journal: Pancreas. 2006 Aug;33(2):148-55.
Title: On the mechanisms of 12-O-tetradecanoylphorbol-13-acetate-induced growth arrest in pancreatic cancer cells.
Author: Salabat, Mohammad R|Ding, Xian Z|Flesche, Jan B|Ujiki, Micheal B|Robin, Tyler P|Talamonti, Mark S|Bell, Richard H Jr|Adrian, Thomas E
PMID: 16868480
34.
Journal: Clin Adv Hematol Oncol. 2006 Nov;4(11):831-6.
Title: Novel targets in solid tumors: MEK inhibitors.
Author: Messersmith, Wells A|Hidalgo, Manuel|Carducci, Michael|Eckhardt, S Gail
PMID: 17143253
35.
Journal: Oncogene. 2007 Mar 29;26(14):2082-94. Epub 2006 Oct 9.
Title: Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway.
Author: Baril, P|Gangeswaran, R|Mahon, P C|Caulee, K|Kocher, H M|Harada, T|Zhu, M|Kalthoff, H|Crnogorac-Jurcevic, T|Lemoine, N R
PMID: 17043657
36.
Journal: Cancer Lett. 2007 May 8;249(2):242-8.
Title: BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas.
Author: Schonleben, Frank|Qiu, Wanglong|Bruckman, Karl C|Ciau, Nancy T|Li, Xiaojun|Lauerman, Margaret H|Frucht, Harold|Chabot, John A|Allendorf, John D|Remotti, Helen E|Su, Gloria H
PMID: 17097223
37.
Journal: J Biol Chem. 2007 May 11;282(19):14048-55. Epub 2007 Mar 12.
Title: Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells.
Author: Ji, Zhenyu|Mei, Fang C|Xie, Jingwu|Cheng, Xiaodong
PMID: 17353198
38.
Journal: J Cell Commun Signal. 2007 Sep;1(2):85-90.
Title: Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK.
Author: Pickles, Melissa|Leask, Andrew
PMID: 18481199
39.
Journal: J Gastrointest Surg. 2008 Feb;12(2):288-96.
Title: Pancreatic cancer cell genetics and signaling response to treatment correlate with efficacy of gemcitabine-based molecular targeting strategies.
Author: Holcomb, Bryan|Yip-Schneider, Michele T|Matos, Jesus M|Dixon, Jennifer|Kennard, Jason|Mahomed, Julie|Shanmugam, Rajasubramaniam|Sebolt-Leopold, Judith|Schmidt, C Max
PMID: 18049840
40.
Journal: Langenbecks Arch Surg. 2008 May;393(3):289-96.
Title: PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/C) of the pancreas.
Author: Schonleben, Frank|Qiu, Wanglong|Remotti, Helen E|Hohenberger, Werner|Su, Gloria H
PMID: 18343945
41.
Journal: Cancer Lett. 2008 Jun 18;264(2):241-9.
Title: MEK inhibitor enhances the inhibitory effect of imatinib on pancreatic cancer cell growth.
Author: Takayama, Yuichi|Kokuryo, Toshio|Yokoyama, Yukihiro|Nagino, Masato|Nimura, Yuji|Senga, Takeshi|Hamaguchi, Michinari
PMID: 18346844
42.
Journal: Curr Med Chem. 2008;15(10):978-90.
Title: ANTI-ADHESION evolves to a promising therapeutic concept in oncology.
Author: Schmidmaier, R|Baumann, P
PMID: 18393855
43.
Journal: Cancer. 2008 Jul 15;113(2):302-14.
Title: High mobility group AT-hook 1 (HMGA1) is an independent prognostic factor and novel therapeutic target in pancreatic adenocarcinoma.
Author: Liau, Siong-Seng|Rocha, Flavio|Matros, Evan|Redston, Mark|Whang, Edward
PMID: 18473350
44.
Journal: Expert Rev Anticancer Ther. 2008 Aug;8(8):1331-8.
Title: Biologic therapies for advanced pancreatic cancer.
Author: He, Aiwu Ruth|Lindenberg, Andreas Peter|Marshall, John Lindsay
PMID: 18699769
45.
Journal: Mol Cancer Ther. 2008 Nov;7(11):3509-18.
Title: Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes.
Author: Lang, Sven A|Schachtschneider, Philipp|Moser, Christian|Mori, Akira|Hackl, Christina|Gaumann, Andreas|Batt, David|Schlitt, Hans J|Geissler, Edward K|Stoeltzing, Oliver
PMID: 19001434
46.
Journal: Expert Rev Gastroenterol Hepatol. 2008 Oct;2(5):673-96.
Title: New treatment options for advanced pancreatic cancer.
Author: Middleton, Gary|Ghaneh, Paula|Costello, Eithne|Greenhalf, William|Neoptolemos, John P
PMID: 19072345
47.
Journal: Am J Pathol. 2009 Mar;174(3):854-68.
Title: HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells.
Author: Watanabe, Sugiko|Ueda, Yasuaki|Akaboshi, Shin-ichi|Hino, Yuko|Sekita, Yoko|Nakao, Mitsuyoshi
PMID: 19179606
48.
Journal: Biochem Biophys Res Commun. 2009 Apr 17;381(4):706-11.
Title: Comparison of ras-responsive gene enhancers in pancreatic tumor cells that express either wild-type or mutant K-ras.
Author: Wilder, Phillip J|Chakravarthy, Harini|Hollingsworth, Michael A|Rizzino, Angie
PMID: 19254697
49.
Journal: J Cell Commun Signal. 2009 Jun;3(2):159-60.
Title: Death of a tumor: targeting CCN in pancreatic cancer.
Author: Leask, Andrew
PMID: 19267221
50.
Journal: Biochem Biophys Res Commun. 2009 Mar 13;380(3):614-9.
Title: Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells.
Author: Kumei, Shima|Motomura, Wataru|Yoshizaki, Takayuki|Takakusaki, Kaoru|Okumura, Toshikatsu
PMID: 19285010
51.
Journal: J Cell Physiol. 2009 Jul;220(1):214-21.
Title: Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines.
Author: Ulivi, Paola|Arienti, Chiara|Amadori, Dino|Fabbri, Francesco|Carloni, Silvia|Tesei, Anna|Vannini, Ivan|Silvestrini, Rosella|Zoli, Wainer
PMID: 19288493
52.
Journal: Mol Cancer Ther. 2009 Apr;8(4):834-43.
Title: KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer.
Author: Yeh, Jen Jen|Routh, Elizabeth D|Rubinas, Tara|Peacock, Janie|Martin, Timothy D|Shen, Xiang Jun|Sandler, Robert S|Kim, Hong Jin|Keku, Temitope O|Der, Channing J
PMID: 19372556
53.
Journal: Biochem Pharmacol. 2009 Nov 1;78(9):1115-26.
Title: Statins inhibit Akt/PKB signaling via P2X7 receptor in pancreatic cancer cells.
Author: Mistafa, Oras|Stenius, Ulla
PMID: 19540829
54.
Journal: Mol Cancer Res. 2009 Aug;7(8):1390-8.
Title: Up-regulation of Kruppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha.
Author: Mori, Akira|Moser, Christian|Lang, Sven A|Hackl, Christina|Gottfried, Eva|Kreutz, Marina|Schlitt, Hans J|Geissler, Edward K|Stoeltzing, Oliver
PMID: 19671674
55.
Journal: Int J Oncol. 2009 Dec;35(6):1237-45.
Title: Activation of two distinct MAPK pathways governs constitutive expression of matrix metalloproteinase-1 in human pancreatic cancer cell lines.
Author: Endo, Hitoshi|Watanabe, Tetsu|Sugioka, Yoshihiko|Niioka, Maki|Inagaki, Yutaka|Okazaki, Isao
PMID: 19885545
56.
Journal: Cancer Biol Ther. 2009 Oct;8(20):1893-901. Epub 2009 Oct 6.
Title: Effects of combined inhibition of MEK and mTOR on downstream signaling and tumor growth in pancreatic cancer xenograft models.
Author: Chang, Qing|Chen, Eric|Hedley, David W
PMID: 20009539
57.
Journal: Zhonghua Zhong Liu Za Zhi. 2009 Oct;31(10):732-7.
Title: [Over-expression of caveolin-1 inhibits proliferation and invasion of pancreatic carcinoma cells in vitro].
Author: Han, Fei|Zhu, Hong-guang
PMID: 20021823
58.
Journal: Int J Cancer. 2010 Jan 15;126(2):395-404.
Title: Increased expression of the heterogeneous nuclear ribonucleoprotein K in pancreatic cancer and its association with the mutant p53.
Author: Zhou, Renyuan|Shanas, Renee|Nelson, Mark A|Bhattacharyya, Achyut|Shi, Jiaqi
PMID: 19609950
59.
Journal: Cancer Res. 2010 Mar 1;70(5):2064-74.
Title: Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis.
Author: Scotti, Michele L|Bamlet, William R|Smyrk, Thomas C|Fields, Alan P|Murray, Nicole R
PMID: 20179210
60.
Journal: J Cell Physiol. 2010 Jul;224(1):112-9.
Title: Sorafenib combined vitamin K induces apoptosis in human pancreatic cancer cell lines through RAF/MEK/ERK and c-Jun NH2-terminal kinase pathways.
Author: Wei, Gang|Wang, Meifang|Carr, Brian I
PMID: 20301194
61.
Journal: J Mol Signal. 2010 Jul 19;5:10.
Title: Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer.
Author: Roy, Sanjit K|Srivastava, Rakesh K|Shankar, Sharmila
PMID: 20642839
62.
Journal: Mol Pharm. 2010 Oct 4;7(5):1576-84.
Title: MEK inhibition potentiates the activity of Hsp90 inhibitor 17-AAG against pancreatic cancer cells.
Author: Zhang, Tao|Li, Yanyan|Zhu, Zhenkun|Gu, Mancang|Newman, Bryan|Sun, Duxin
PMID: 20669973
63.
Journal: BMC Cancer. 2010 Sep 28;10:515.
Title: Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with rapamycin in human orthotopic primary pancreatic cancer xenografts.
Author: Chang, Qing|Chapman, Mark S|Miner, Jeffrey N|Hedley, David W
PMID: 20920162
64.
Journal: J Mol Signal. 2010 Nov 2;5:18.
Title: TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling.
Author: Campbell, Paul M|Boufaied, Nadia|Fiordalisi, James J|Cox, Adrienne D|Falardeau, Pierre|Der, Channing J|Gourdeau, Henriette
PMID: 21044336
65.
Journal: Mol Med Rep. 2010 Jan-Feb;3(1):149-53.
Title: Analysis of invasion-metastasis in pancreatic cancer: Correlation between the expression and arrangement of tight junction protein-2 and cell dissociation in pancreatic cancer cells.
Author: Zhou, Lei|Tan, Xiaodong|Wang, Wei|Wang, Baosheng|Dai, Xianwei|Liu, Jingang
PMID: 21472214
66.
Journal: Invest New Drugs. 2011 Oct;29(5):777-85.
Title: A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis.
Author: Guzman, Esther A|Johnson, Jacob D|Linley, Patricia A|Gunasekera, Sarath E|Wright, Amy E
PMID: 20352293
67.
Journal: Cancer Lett. 2011 Apr 28;303(2):108-17.
Title: Stem cell factor/c-kit signaling enhances invasion of pancreatic cancer cells via HIF-1alpha under normoxic condition.
Author: Zhang, Min|Ma, Qingyong|Hu, Hengtong|Zhang, Dong|Li, Junhui|Ma, Guodong|Bhat, Kruttika|Wu, Erxi
PMID: 21320746
68.
Journal: Clin Cancer Res. 2011 May 1;17(9):2744-56.
Title: Synergistic effect between erlotinib and MEK inhibitors in KRAS wild-type human pancreatic cancer cells.
Author: Diep, Caroline H|Munoz, Ruben M|Choudhary, Ashish|Von Hoff, Daniel D|Han, Haiyong
PMID: 21385921
69.
Journal: Mol Cells. 2011 Jun;31(6):579-83.
Title: Silencing of BNIP3 results from promoter methylation by DNA methyltransferase 1 induced by the mitogen-activated protein kinase pathway.
Author: An, Hyun-Jung|Lee, Hayyoung|Paik, Sang-Gi
PMID: 21573703
70.
Journal: Free Radic Biol Med. 2011 Sep 15;51(6):1164-74.
Title: Tocotrienols inhibit AKT and ERK activation and suppress pancreatic cancer cell proliferation by suppressing the ErbB2 pathway.
Author: Shin-Kang, Sonyo|Ramsauer, Victoria P|Lightner, Janet|Chakraborty, Kanishka|Stone, William|Campbell, Sharon|Reddy, Shrikanth A G|Krishnan, Koyamangalath
PMID: 21723941
71.
Journal: PLoS One. 2011;6(9):e25166.
Title: Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors.
Author: Roy, Sanjit K|Chen, Qinghe|Fu, Junsheng|Shankar, Sharmila|Srivastava, Rakesh K
PMID: 21980390
72.
Journal: Anticancer Res. 2011 Nov;31(11):3747-56.
Title: Mechanisms underlying gemcitabine resistance in pancreatic cancer and sensitisation by the iMiD lenalidomide.
Author: Fryer, Rosemary A|Barlett, Blake|Galustian, Christine|Dalgleish, Angus G
PMID: 22110196
73.
Journal: Cancer. 2011 Jun 1;117(11):2408-18.
Title: Epidermal growth factor down-regulates the expression of neutrophil gelatinase-associated lipocalin (NGAL) through E-cadherin in pancreatic cancer cells.
Author: Tong, Zhimin|Chakraborty, Subhankar|Sung, Bokyung|Koolwal, Pooja|Kaur, Sukhwinder|Aggarwal, Bharat B|Mani, Sendurai A|Bresalier, Robert S|Batra, Surinder K|Guha, Sushovan
PMID: 24048788
74.
Journal: Invest New Drugs. 2012 Jun;30(3):1216-23.
Title: A phase II open-label randomized study to assess the efficacy and safety of selumetinib (AZD6244 [ARRY-142886]) versus capecitabine in patients with advanced or metastatic pancreatic cancer who have failed first-line gemcitabine therapy.
Author: Bodoky, Gyorgy|Timcheva, Constanta|Spigel, David Robert|La Stella, Phillip Joseph|Ciuleanu, Tudor Eliade|Pover, G|Tebbutt, N C
PMID: 21594619
75.
Journal: Mod Pathol. 2012 May;25(5):758-66.
Title: Overexpression and oncogenic function of aldo-keto reductase family 1B10 (AKR1B10) in pancreatic carcinoma.
Author: Chung, Yeon Tae|Matkowskyj, Kristina A|Li, Haonan|Bai, Han|Zhang, Wanying|Tsao, Ming-Sound|Liao, Jie|Yang, Guang-Yu
PMID: 22222635
76.
Journal: Mol Cancer Ther. 2012 May;11(5):1193-202.
Title: Cotargeting MAPK and PI3K signaling with concurrent radiotherapy as a strategy for the treatment of pancreatic cancer.
Author: Williams, Terence M|Flecha, Athena R|Keller, Paul|Ram, Ashwin|Karnak, David|Galban, Stefanie|Galban, Craig J|Ross, Brian D|Lawrence, Theodore S|Rehemtulla, Alnawaz|Sebolt-Leopold, Judith
PMID: 22411900
77.
Journal: Pancreas. 2012 Jul;41(5):745-52.
Title: Transforming growth factor beta and Ras/MEK/ERK signaling regulate the expression level of a novel tumor suppressor Lefty.
Author: Miyata, Naoteru|Azuma, Toshifumi|Hozawa, Shigenari|Higuchi, Hajime|Yokoyama, Akiko|Kabashima, Ayano|Igarashi, Toru|Saeki, Keita|Hibi, Toshifumi
PMID: 22441145
78.
Journal: JOP. 2012 Jul 10;13(4):354-7.
Title: New tools and novel approaches in treating locally advanced pancreatic adenocarcinoma.
Author: Ahmed, Wesam B|Ng, John|Wazer, David E|Saif, Muhammad Wasif
PMID: 22797388
79.
Journal: Mol Cancer Res. 2012 Dec;10(12):1607-19.
Title: Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity.
Author: Gysin, Stephan|Paquette, Jesse|McMahon, Martin
PMID: 22833572
80.
Journal: Clin Transl Oncol. 2012 Nov;14(11):848-52.
Title: Reduced expression of Raf kinase inhibitor protein correlates with poor prognosis in pancreatic cancer.
Author: Song, Shi-peng|Zhang, Sheng-bin|Li, Zhe-hai|Zhou, Yong-sheng|Li, Bing|Bian, Zhan-wei|Liao, Qian-de|Zhang, Yang-de
PMID: 22855160
81.
Journal: PLoS One. 2012;7(8):e44146.
Title: K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo.
Author: Hofmann, Irmgard|Weiss, Andreas|Elain, Gaelle|Schwaederle, Maria|Sterker, Dario|Romanet, Vincent|Schmelzle, Tobias|Lai, Albert|Brachmann, Saskia M|Bentires-Alj, Mohamed|Roberts, Thomas M|Sellers, William R|Hofmann, Francesco|Maira, Sauveur-Michel
PMID: 22952903
82.
Journal: Carcinogenesis. 2012 Dec;33(12):2467-76.
Title: Transcriptional regulation of the interleukin-11 gene by oncogenic Ras.
Author: Shin, Soon Young|Choi, Chan|Lee, Hong Ghi|Lim, Yoongho|Lee, Young Han
PMID: 23027619
83.
Journal: World J Gastroenterol. 2012 Nov 21;18(43):6226-34.
Title: Insights into erlotinib action in pancreatic cancer cells using a combined experimental and mathematical approach.
Author: Lange, Falko|Rateitschak, Katja|Kossow, Christina|Wolkenhauer, Olaf|Jaster, Robert
PMID: 23180942
84.
Journal: Cancer Lett. 2013 Jun 28;334(1):118-26.
Title: Grape seed proanthocyanidins inhibit migration potential of pancreatic cancer cells by promoting mesenchymal-to-epithelial transition and targeting NF-kappaB.
Author: Prasad, Ram|Katiyar, Santosh K
PMID: 22902508
85.
Journal: Carcinogenesis. 2013 Mar;34(3):694-702.
Title: Collagen triple helix repeat containing-1 promotes pancreatic cancer progression by regulating migration and adhesion of tumor cells.
Author: Park, Eun Hye|Kim, Seokho|Jo, Ji Yoon|Kim, Su Jin|Hwang, Yeonsil|Kim, Jin-Man|Song, Si Young|Lee, Dong-Ki|Koh, Sang Seok
PMID: 23222813
86.
Journal: Cancer Lett. 2013 May 1;331(2):250-61.
Title: Synergistic anticancer activity of HS-173, a novel PI3K inhibitor in combination with Sorafenib against pancreatic cancer cells.
Author: Yun, Sun-Mi|Jung, Kyung Hee|Lee, Hyunseung|Son, Mi Kwon|Seo, Ju-Hyeon|Yan, Hong Hua|Park, Byung Hee|Hong, Sungwoo|Hong, Soon-Sun
PMID: 23340175
87.
Journal: FASEB J. 2013 Jun;27(6):2165-74.
Title: Suppression of Lefty expression in induced pluripotent cancer cells.
Author: Saito, Akiko|Ochiai, Hiromi|Okada, Shoko|Miyata, Naoteru|Azuma, Toshifumi
PMID: 23407711
88.
Journal: Neoplasia. 2013 Feb;15(2):143-55.
Title: Inhibition of the growth of patient-derived pancreatic cancer xenografts with the MEK inhibitor trametinib is augmented by combined treatment with the epidermal growth factor receptor/HER2 inhibitor lapatinib.
Author: Walters, Dustin M|Lindberg, James M|Adair, Sara J|Newhook, Timothy E|Cowan, Catharine R|Stokes, Jayme B|Borgman, Cheryl A|Stelow, Edward B|Lowrey, Bryce T|Chopivsky, Maria E|Gilmer, Tona M|Parsons, John T|Bauer, Todd W
PMID: 23441129
89.
Journal: Mol Cancer Ther. 2013 Jun;12(6):853-64.
Title: Bcl-2/Bcl-xL inhibition increases the efficacy of MEK inhibition alone and in combination with PI3 kinase inhibition in lung and pancreatic tumor models.
Author: Tan, Nguyen|Wong, Maureen|Nannini, Michelle A|Hong, Rebecca|Lee, Leslie B|Price, Stephen|Williams, Karen|Savy, Pierre Pascal|Yue, Peng|Sampath, Deepak|Settleman, Jeffrey|Fairbrother, Wayne J|Belmont, Lisa D
PMID: 23475955
90.
Journal: J Exp Clin Cancer Res. 2013 Mar 6;32:12.
Title: Enhancing sorafenib-mediated sensitization to gemcitabine in experimental pancreatic cancer through EMAP II.
Author: Awasthi, Niranjan|Zhang, Changhua|Hinz, Stefan|Schwarz, Margaret A|Schwarz, Roderich E
PMID: 23497499
91.
Journal: Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6079-84.
Title: Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment.
Author: Phan, Vernon T|Wu, Xiumin|Cheng, Jason H|Sheng, Rebecca X|Chung, Alicia S|Zhuang, Guanglei|Tran, Christopher|Song, Qinghua|Kowanetz, Marcin|Sambrone, Amy|Tan, Martha|Meng, Y Gloria|Jackson, Erica L|Peale, Franklin V|Junttila, Melissa R|Ferrara, Napoleone
PMID: 23530240
92.
Journal: Eur J Cancer. 2013 Jun;49(9):2077-85.
Title: A phase 1b study of trametinib, an oral Mitogen-activated protein kinase kinase (MEK) inhibitor, in combination with gemcitabine in advanced solid tumours.
Author: Infante, Jeffrey R|Papadopoulos, Kyriakos P|Bendell, Johanna C|Patnaik, Amita|Burris, Howard A 3rd|Rasco, Drew|Jones, Suzanne F|Smith, Lon|Cox, Donna S|Durante, Michael|Bellew, Kevin M|Park, Joohyun Jennifer|Le, Ngocdiep T|Tolcher, Anthony W
PMID: 23583440
93.
Journal: Cell Biol Int. 2013 May;37(5):478-84.
Title: Direct TGF-beta1 signaling between activated platelets and pancreatic cancer cells primes cisplatin insensitivity.
Author: Chen, Hongxu|Lan, Xiang|Liu, Menggang|Zhou, Bo|Wang, Baoling|Chen, Ping
PMID: 23584798
94.
Journal: Pancreas. 2013 Oct;42(7):1060-9.
Title: Modulation of pancreatic tumor potential by overexpression of protein kinase C beta1.
Author: Cirigliano, Stefano M|Mauro, Laura V|Grossoni, Valeria C|Colombo, Lucas L|Diament, Miriam J|Kazanietz, Marcelo G|Bal de Kier Joffe, Elisa D|Puricelli, Lydia I|Urtreger, Alejandro J
PMID: 23695799
95.
Journal: Am J Pathol. 2013 Aug;183(2):566-75.
Title: Activated PAR-2 regulates pancreatic cancer progression through ILK/HIF-alpha-induced TGF-alpha expression and MEK/VEGF-A-mediated angiogenesis.
Author: Chang, Li-Hsun|Pan, Shiow-Lin|Lai, Chin-Yu|Tsai, An-Chi|Teng, Che-Ming
PMID: 23764046
96.
Journal: JOP. 2013 Jul 10;14(4):395-400.
Title: Novel agents and future prospects in the treatment of pancreatic adenocarcinoma.
Author: Sarris, Evangelos G|Syrigos, Kostas N|Saif, Muhammad Wasif
PMID: 23846936
97.
Journal: Mol Cancer Ther. 2013 Oct;12(10):2213-25.
Title: Subtype-specific MEK-PI3 kinase feedback as a therapeutic target in pancreatic adenocarcinoma.
Author: Mirzoeva, Olga K|Collisson, Eric A|Schaefer, Peter M|Hann, Byron|Hom, Yun K|Ko, Andrew H|Korn, W Michael
PMID: 23918833
98.
Journal: Biochem Biophys Res Commun. 2013 Sep 13;439(1):6-11.
Title: miR-143 decreases COX-2 mRNA stability and expression in pancreatic cancer cells.
Author: Pham, Hung|Rodriguez, C Ekaterina|Donald, Graham W|Hertzer, Kathleen M|Jung, Xiaoman S|Chang, Hui-Hua|Moro, Aune|Reber, Howard A|Hines, O Joe|Eibl, Guido
PMID: 23973710
99.
Journal: PLoS One. 2013 Oct 9;8(10):e77243.
Title: Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models.
Author: Zhong, Hua|Sanchez, Cesar|Spitzer, Dirk|Plambeck-Suess, Stacy|Gibbs, Jesse|Hawkins, Williams G|Denardo, David|Gao, Feng|Pufahl, Robert A|Lockhart, Albert C|Xu, Mai|Linehan, David|Weber, Jason|Wang-Gillam, Andrea
PMID: 24130864
100.
Journal: ScientificWorldJournal. 2013 Oct 30;2013:607524.
Title: Transcriptional regulation of Delta6-desaturase by peroxisome proliferative-activated receptor delta agonist in human pancreatic cancer cells: role of MEK/ERK1/2 pathway.
Author: Darabi, Maryam|Byagowi, Shima|Fayezi, Shabnam|Darabi, Masoud|Mirshahvaladi, Shahab|Sahmani, Mehdi
PMID: 24294133
101.
Journal: Genet Mol Res. 2013 Nov 18;12(4):5560-73.
Title: Effect of inhibition of MEK pathway on 5-aza-deoxycytidine-suppressed pancreatic cancer cell proliferation.
Author: Wang, X|Wang, H|Jiang, N|Lu, W|Zhang, X F|Fang, J Y
PMID: 24301926
102.
Journal: J Transl Med. 2013 Dec 14;11:311.
Title: Loss of Raf-1 kinase inhibitor protein (RKIP) is strongly associated with high-grade tumor budding and correlates with an aggressive phenotype in pancreatic ductal adenocarcinoma (PDAC).
Author: Karamitopoulou, Eva|Zlobec, Inti|Gloor, Beat|Kondi-Pafiti, Agathi|Lugli, Alessandro|Perren, Aurel
PMID: 24330423
103.
Journal: PLoS One. 2013 Dec 31;8(12):e85502.
Title: The MEK/ERK pathway promotes NOTCH signalling in pancreatic cancer cells.
Author: Tremblay, Isabelle|Pare, Emanuel|Arsenault, Dominique|Douziech, Melanie|Boucher, Marie-Josee
PMID: 24392017
104.
Journal: Neoplasia. 2013 Dec;15(12):1354-62.
Title: Synthetic lethality screen identifies RPS6KA2 as modifier of epidermal growth factor receptor activity in pancreatic cancer.
Author: Milosevic, Nada|Kuhnemuth, Benjamin|Muhlberg, Leonie|Ripka, Stefanie|Griesmann, Heidi|Lolkes, Carolin|Buchholz, Malte|Aust, Daniela|Pilarsky, Christian|Krug, Sebastian|Gress, Thomas|Michl, Patrick
PMID: 24403857
105.
Journal: Mol Carcinog. 2014 Oct;53(10):787-92.
Title: Up-regulated cten by FGF2 contributes to FGF2-mediated cell migration.
Author: Hung, Shih-Ya|Shih, Yi-Ping|Chen, Michelle|Lo, Su Hao
PMID: 23625726
106.
Journal: Curr Med Chem. 2014;21(8):948-65.
Title: Target therapies in pancreatic carcinoma.
Author: Silvestris, Nicola|Gnoni, Antonio|Brunetti, Anna Elisabetta|Vincenti, Leonardo|Santini, Daniele|Tonini, Giuseppe|Merchionne, Francesca|Maiello, Evaristo|Lorusso, Vito|Nardulli, Patrizia|Azzariti, Amalia|Reni, Michele
PMID: 23992319
107.
Journal: Oncogene. 2014 Sep 18;33(38):4664-74.
Title: microRNA-10b enhances pancreatic cancer cell invasion by suppressing TIP30 expression and promoting EGF and TGF-beta actions.
Author: Ouyang, H|Gore, J|Deitz, S|Korc, M
PMID: 24096486
108.
Journal: J Cell Physiol. 2014 Jul;229(7):887-97.
Title: Overexpression of calreticulin contributes to the development and progression of pancreatic cancer.
Author: Sheng, Weiwei|Chen, Chuanping|Dong, Ming|Zhou, Jianping|Liu, Qingfeng|Dong, Qi|Li, Feng
PMID: 24264800
109.
Journal: Pharmacol Res. 2014 Jan;79:34-74.
Title: The ErbB/HER family of protein-tyrosine kinases and cancer.
Author: Roskoski, Robert Jr
PMID: 24269963
110.
Journal: J Clin Invest. 2014 Jan;124(1):338-52.
Title: Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-beta to promote proliferation.
Author: Gore, A Jesse|Deitz, Samantha L|Palam, Lakshmi Reddy|Craven, Kelly E|Korc, Murray
PMID: 24334458
111.
Journal: Cancer Res. 2014 Jun 15;74(12):3344-56.
Title: Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma.
Author: Davies, Clare C|Harvey, Emma|McMahon, Raymond F T|Finegan, Katherine G|Connor, Frances|Davis, Roger J|Tuveson, David A|Tournier, Cathy
PMID: 24713432
112.
Journal: Int J Oncol. 2014 Jul;45(1):311-21.
Title: HS-104, a PI3K inhibitor, enhances the anticancer efficacy of gemcitabine in pancreatic cancer.
Author: Jung, Kyung Hee|Yan, Hong Hua|Fang, Zhenghuan|Son, Mi Kwon|Lee, Hyunseung|Hong, Sungwoo|Hong, Soon-Sun
PMID: 24819705
113.
Journal: Cell Death Dis. 2014 May 22;5:e1241.
Title: Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice.
Author: Xiao, Z|Li, L|Li, Y|Zhou, W|Cheng, J|Liu, F|Zheng, P|Zhang, Y|Che, Y
PMID: 24853419
114.
Journal: Eur J Cancer. 2014 Aug;50(12):2072-81.
Title: A randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas.
Author: Infante, Jeffrey R|Somer, Bradley G|Park, Joon Oh|Li, Chung-Pin|Scheulen, Max E|Kasubhai, Saifuddin M|Oh, Do-Youn|Liu, Yuan|Redhu, Suman|Steplewski, Klaudia|Le, Ngocdiep
PMID: 24915778
115.
Journal: Clin Cancer Res. 2014 Dec 1;20(23):6200-11.
Title: Functional p38 MAPK identified by biomarker profiling of pancreatic cancer restrains growth through JNK inhibition and correlates with improved survival.
Author: Zhong, Yi|Naito, Yoshiki|Cope, Leslie|Naranjo-Suarez, Salvador|Saunders, Tyler|Hong, Seung-Mo|Goggins, Michael G|Herman, Joseph M|Wolfgang, Christopher L|Iacobuzio-Donahue, Christine A
PMID: 24963048
116.
Journal: Neoplasia. 2014 Jul;16(7):562-71.
Title: Co-treatment with panitumumab and trastuzumab augments response to the MEK inhibitor trametinib in a patient-derived xenograft model of pancreatic cancer.
Author: Lindberg, James M|Newhook, Timothy E|Adair, Sara J|Walters, Dustin M|Kim, Alison J|Stelow, Edward B|Parsons, J Thomas|Bauer, Todd W
PMID: 25117978
117.
Journal: Oncotarget. 2014 Aug 15;5(15):6512-25.
Title: CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer.
Author: Franco, Jorge|Witkiewicz, Agnieszka K|Knudsen, Erik S
PMID: 25156567
118.
Journal: Br J Cancer. 2014 Oct 28;111(9):1788-801.
Title: KRAS mutational subtype and copy number predict in vitro response of human pancreatic cancer cell lines to MEK inhibition.
Author: Hamidi, H|Lu, M|Chau, K|Anderson, L|Fejzo, M|Ginther, C|Linnartz, R|Zubel, A|Slamon, D J|Finn, R S
PMID: 25167228
119.
Journal: Cancer Discov. 2014 Dec;4(12):1398-405.
Title: Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes.
Author: Chmielecki, Juliann|Hutchinson, Katherine E|Frampton, Garrett M|Chalmers, Zachary R|Johnson, Adrienne|Shi, Chanjuan|Elvin, Julia|Ali, Siraj M|Ross, Jeffrey S|Basturk, Olca|Balasubramanian, Sohail|Lipson, Doron|Yelensky, Roman|Pao, William|Miller, Vincent
PMID: 25266736
120.
Journal: PLoS One. 2014 Oct 1;9(10):e109076.
Title: Gemcitabine induces poly (ADP-ribose) polymerase-1 (PARP-1) degradation through autophagy in pancreatic cancer.
Author: Wang, Yufeng|Kuramitsu, Yasuhiro|Tokuda, Kazuhiro|Baron, Byron|Kitagawa, Takao|Akada, Junko|Maehara, Shin-ichiro|Maehara, Yoshihiko|Nakamura, Kazuyuki
PMID: 25271986
121.
Journal: Bioessays. 2014 Dec;36(12):1162-9.
Title: Lysine methylation in cancer: SMYD3-MAP3K2 teaches us new lessons in the Ras-ERK pathway.
Author: Colon-Bolea, Paula|Crespo, Piero
PMID: 25382779
122.
Journal: Acta Histochem. 2014 Oct;116(8):1434-42.
Title: Dynamic distribution of ERK, p38 and JNK during the development of pancreatic ductal adenocarcinoma.
Author: Amsterdam, Abraham|Shpigner, Lotem|Raanan, Calanit|Schreiber, Letizia|Melzer, Ehud|Seger, Rony
PMID: 25440531
123.
Journal: Ann Oncol. 2015 Jan;26(1):58-64.
Title: A phase IB trial of the oral MEK inhibitor trametinib (GSK1120212) in combination with everolimus in patients with advanced solid tumors.
Author: Tolcher, A W|Bendell, J C|Papadopoulos, K P|Burris, H A 3rd|Patnaik, A|Jones, S F|Rasco, D|Cox, D S|Durante, M|Bellew, K M|Park, J|Le, N T|Infante, J R
PMID: 25344362
124.
Journal: Clin Cancer Res. 2015 Jan 15;21(2):396-404.
Title: Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer.
Author: Alagesan, Brinda|Contino, Gianmarco|Guimaraes, Alex R|Corcoran, Ryan B|Deshpande, Vikram|Wojtkiewicz, Gregory R|Hezel, Aram F|Wong, Kwok-Kin|Loda, Massimo|Weissleder, Ralph|Benes, Cyril H|Engelman, Jeffrey|Bardeesy, Nabeel
PMID: 25348516
125.
Journal: Mol Cancer Ther. 2015 Jan;14(1):40-7.
Title: Modeling targeted inhibition of MEK and PI3 kinase in human pancreatic cancer.
Author: Junttila, Melissa R|Devasthali, Vidusha|Cheng, Jason H|Castillo, Joseph|Metcalfe, Ciara|Clermont, Anne C|Otter, Douglas Den|Chan, Emily|Bou-Reslan, Hani|Cao, Tim|Forrest, William|Nannini, Michelle A|French, Dorothy|Carano, Richard|Merchant, Mark|Hoeflich,
PMID: 25376606
126.
Journal: Biochem Biophys Res Commun. 2015 Jan 16;456(3):821-6.
Title: The glucosylceramide synthase inhibitor PDMP sensitizes pancreatic cancer cells to MEK/ERK inhibitor AZD-6244.
Author: Wang, Ting|Wei, Jue|Wang, Na|Ma, Jia-Li|Hui, Ping-Ping
PMID: 25498501
127.
Journal: Clin Cancer Res. 2015 Feb 15;21(4):730-8.
Title: A phase Ib dose-escalation study of the oral pan-PI3K inhibitor buparlisib (BKM120) in combination with the oral MEK1/2 inhibitor trametinib (GSK1120212) in patients with selected advanced solid tumors.
Author: Bedard, Philippe L|Tabernero, Josep|Janku, Filip|Wainberg, Zev A|Paz-Ares, Luis|Vansteenkiste, Johan|Van Cutsem, Eric|Perez-Garcia, Jose|Stathis, Anastasios|Britten, Carolyn D|Le, Ngocdiep|Carter, Kirsten|Demanse, David|Csonka, Denes|Peters, Malte|Zubel,
PMID: 25500057
128.
Journal: Can J Diabetes. 2015 Apr;39(2):123-7.
Title: Effect of PPARdelta agonist on stearoyl-CoA desaturase 1 in human pancreatic cancer cells: role of MEK/ERK1/2 pathway.
Author: Byagowi, Shima|Naserpour Farivar, Taghi|Najafipour, Reza|Sahmani, Mehdi|Darabi, Masoud|Fayezi, Shabnam|Mirshahvaladi, Shahab|Darabi, Maryam
PMID: 25575964
129.
Journal: Oncotarget. 2015 Mar 10;6(7):4829-44.
Title: Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: involvement of protein kinase C-theta activation.
Author: Takahashi, Tetsuyuki|Uehara, Hisanori|Ogawa, Hirohisa|Umemoto, Hitomi|Bando, Yoshimi|Izumi, Keisuke
PMID: 25638159
130.
Journal: Mol Cancer Ther. 2015 Apr;14(4):1014-23.
Title: Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2.
Author: Soares, Heloisa P|Ming, Ming|Mellon, Michelle|Young, Steven H|Han, Liang|Sinnet-Smith, James|Rozengurt, Enrique
PMID: 25673820
131.
Journal: Bioorg Med Chem. 2015 Apr 1;23(7):1386-94.
Title: Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor.
Author: Van Dort, Marcian E|Galban, Stefanie|Wang, Hanxiao|Sebolt-Leopold, Judith|Whitehead, Christopher|Hong, Hao|Rehemtulla, Alnawaz|Ross, Brian D
PMID: 25766633
132.
Journal: Oncoscience. 2015 Mar 14;2(3):285-93.
Title: N of 1 case reports of exceptional responders accrued from pancreatic cancer patients enrolled in first-in-man studies from 2002 through 2012.
Author: Garrido-Laguna, Ignacio|Tometich, Danielle|Hu, Nan|Ying, Jian|Geiersbach, Katherine|Whisenant, Jonathan|Wang, Kai|Ross, Jeffrey S|Sharma, Sunil
PMID: 25897431
133.
Journal: Oncotarget. 2015 Jun 10;6(16):14472-87.
Title: Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells.
Author: Zhao, Chengguang|Xiao, Hui|Wu, Xiaojuan|Li, Chenglong|Liang, Guang|Yang, Shulin|Lin, Jiayuh
PMID: 25961376
134.
Journal: Clin Cancer Res. 2015 Dec 15;21(24):5563-77.
Title: The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy in Pancreatic Cancer Models by Altering Ribonucleotide Reductase Subunit-1 (RRM1).
Author: Vena, Francesca|Li Causi, Eleonora|Rodriguez-Justo, Manuel|Goodstal, Samantha|Hagemann, Thorsten|Hartley, John A|Hochhauser, Daniel
PMID: 26228206
135.
Journal: Adv Biol Regul. 2015 Sep;59:65-81.
Title: Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells.
Author: Fitzgerald, Timothy L|Lertpiriyapong, Kvin|Cocco, Lucio|Martelli, Alberto M|Libra, Massimo|Candido, Saverio|Montalto, Giuseppe|Cervello, Melchiorre|Steelman, Linda|Abrams, Stephen L|McCubrey, James A
PMID: 26257206
136.
Journal: Front Cell Dev Biol. 2015 Aug 5;3:47.
Title: Repression of CD24 surface protein expression by oncogenic Ras is relieved by inhibition of Raf but not MEK or PI3K.
Author: Pallegar, Nikitha K|Ayre, D Craig|Christian, Sherri L
PMID: 26301220
137.
Journal: Cell Cycle. 2015;14(23):3713-24.
Title: MEK inhibitor GSK1120212-mediated radiosensitization of pancreatic cancer cells involves inhibition of DNA double-strand break repair pathways.
Author: Estrada-Bernal, Adriana|Chatterjee, Moumita|Haque, S Jaharul|Yang, Linlin|Morgan, Meredith A|Kotian, Shweta|Morrell, David|Chakravarti, Arnab|Williams, Terence M
PMID: 26505547
138.
Journal: Clin Cancer Res. 2016 Jan 1;22(1):61-8.
Title: A Multicenter, Open-Label Phase II Clinical Trial of Combined MEK plus EGFR Inhibition for Chemotherapy-Refractory Advanced Pancreatic Adenocarcinoma.
Author: Ko, Andrew H|Bekaii-Saab, Tanios|Van Ziffle, Jessica|Mirzoeva, Olga M|Joseph, Nancy M|Talasaz, AmirAli|Kuhn, Peter|Tempero, Margaret A|Collisson, Eric A|Kelley, R Kate|Venook, Alan P|Dito, Elizabeth|Ong, Anna|Ziyeh, Sharvina|Courtin, Ryan|Linetskaya, Regi
PMID: 26251290
139.
Journal: Acta Biochim Biophys Sin (Shanghai). 2016 Jan;48(1):27-38.
Title: RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
Author: Fang, Bingliang
PMID: 26350096
140.
Journal: Cancer Res. 2016 May 1;76(9):2612-25.
Title: Genomic Loss of DUSP4 Contributes to the Progression of Intraepithelial Neoplasm of Pancreas to Invasive Carcinoma.
Author: Hijiya, Naoki|Tsukamoto, Yoshiyuki|Nakada, Chisato|Tung Nguyen, Lam|Kai, Tomoki|Matsuura, Keiko|Shibata, Kohei|Inomata, Masafumi|Uchida, Tomohisa|Tokunaga, Akinori|Amada, Kohei|Shirao, Kuniaki|Yamada, Yasunari|Mori, Hiromu|Takeuchi, Ichiro|Seto, Masao|Aok
PMID: 26941286
141.
Journal: Clin Ther. 2016 Jul;38(7):1622-35.
Title: Genetic Testing in Pancreatic Ductal Adenocarcinoma: Implications for Prevention and Treatment.
Author: Peters, Mary Linton B|Tseng, Jennifer F|Miksad, Rebecca A
PMID: 27041411
142.
Journal: Nature. 2016 Jun 30;534(7609):647-51.
Title: A combinatorial strategy for treating KRAS-mutant lung cancer.
Author: Manchado, Eusebio|Weissmueller, Susann|Morris, John P 4th|Chen, Chi-Chao|Wullenkord, Ramona|Lujambio, Amaia|de Stanchina, Elisa|Poirier, John T|Gainor, Justin F|Corcoran, Ryan B|Engelman, Jeffrey A|Rudin, Charles M|Rosen, Neal|Lowe, Scott W
PMID: 27338794
143.
Journal: Pharmacol Res. 2016 Sep;111:757-766.
Title: Selective GPR55 antagonism reduces chemoresistance in cancer cells.
Author: Singh, Nagendra S|Bernier, Michel|Wainer, Irving W
PMID: 27423937
144.
Journal: Neoplasia. 2016 Jul;18(7):425-35.
Title: Upstream and Downstream Co-inhibition of Mitogen-Activated Protein Kinase and PI3K/Akt/mTOR Pathways in Pancreatic Ductal Adenocarcinoma.
Author: Wong, Matthew H|Xue, Aiqun|Baxter, Robert C|Pavlakis, Nick|Smith, Ross C
PMID: 27435925
145.
Journal: Pharmacol Ther. 2016 Dec;168:29-42.
Title: KRAS-related proteins in pancreatic cancer.
Author: Mann, Karen M|Ying, Haoqiang|Juan, Joseph|Jenkins, Nancy A|Copeland, Neal G
PMID: 27595930
146.
Journal: Anticancer Res. 2016 Sep;36(9):4537-43.
Title: MEK Inhibitor Suppresses Expression of the miR-17-92 Cluster with G1-Phase Arrest in HT-29 Human Colon Cancer Cells and MIA PaCa-2 Pancreatic Cancer Cells.
Author: Tanaka, Ryoichi|Tomosugi, Mitsuhiro|Sakai, Toshiyuki|Sowa, Yoshihiro
PMID: 27630293
147.
Journal: Oncotarget. 2016 Oct 25;7(43):69804-69815.
Title: Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras.
Author: Bahr, Julian C|Robey, Robert W|Luchenko, Victoria|Basseville, Agnes|Chakraborty, Arup R|Kozlowski, Hanna|Pauly, Gary T|Patel, Paresma|Schneider, Joel P|Gottesman, Michael M|Bates, Susan E
PMID: 27634878
148.
Journal: Prostaglandins Leukot Essent Fatty Acids. 2016 Dec;115:67-76.
Title: Leukotriene B4 induces EMT and vimentin expression in PANC-1 pancreatic cancer cells: Involvement of BLT2 via ERK2 activation.
Author: Kim, You Ri|Park, Mi Kyung|Kang, Gyeong Jin|Kim, Hyun Ji|Kim, Eun Ji|Byun, Hyun Jung|Lee, Moo-Yeol|Lee, Chang Hoon
PMID: 27914516
149.
Journal: JAMA Oncol. 2017 Apr 1;3(4):516-522.
Title: Effect of Selumetinib and MK-2206 vs Oxaliplatin and Fluorouracil in Patients With Metastatic Pancreatic Cancer After Prior Therapy: SWOG S1115 Study Randomized Clinical Trial.
Author: Chung, Vincent|McDonough, Shannon|Philip, Philip A|Cardin, Dana|Wang-Gillam, Andrea|Hui, Laifong|Tejani, Mohamedtaki A|Seery, Tara E|Dy, Irene A|Al Baghdadi, Tareq|Hendifar, Andrew E|Doyle, L Austin|Lowy, Andrew M|Guthrie, Katherine A|Blanke, Charles D|Ho
PMID: 27978579
150.
Journal: Pancreas. 2017 Feb;46(2):268-275.
Title: Gemcitabine Enhances Kras-MEK-Induced Matrix Metalloproteinase-10 Expression Via Histone Acetylation in Gemcitabine-Resistant Pancreatic Tumor-initiating Cells.
Author: Shimizu, Kazuya|Nishiyama, Takaaki|Hori, Yuichi
PMID: 28060183
151.
Journal: Cell Mol Gastroenterol Hepatol. 2017 Jan;3(1):99-118.
Title: Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis.
Author: Halbrook, Christopher J|Wen, Hui-Ju|Ruggeri, Jeanine M|Takeuchi, Kenneth K|Zhang, Yaqing|di Magliano, Marina Pasca|Crawford, Howard C
PMID: 28090569
152.
Journal: Cell Rep. 2017 Feb 7;18(6):1543-1557.
Title: ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition.
Author: Wang, Belinda|Krall, Elsa Beyer|Aguirre, Andrew James|Kim, Miju|Widlund, Hans Ragnar|Doshi, Mihir Bhavik|Sicinska, Ewa|Sulahian, Rita|Goodale, Amy|Cowley, Glenn Spencer|Piccioni, Federica|Doench, John Gerard|Root, David Edward|Hahn, William Chun
PMID: 28178529
153.
Journal: Expert Opin Emerg Drugs. 2017 Mar;22(1):77-86.
Title: Emerging protein kinase inhibitors for treating pancreatic cancer.
Author: Furuse, Junji|Nagashima, Fumio
PMID: 28253828
154.
Journal: Oncotarget. 2017 Jul 18;8(29):47490-47496.
Title: MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX).
Author: Kawaguchi, Kei|Igarashi, Kentaro|Murakami, Takashi|Kiyuna, Tasuku|Lwin, Thinzar M|Hwang, Ho Kyoung|Delong, Jonathan C|Clary, Bryan M|Bouvet, Michael|Unno, Michiaki|Hoffman, Robert M
PMID: 28537897
155.
Journal: Oncogene. 2017 Oct 5;36(40):5639-5647.
Title: Pancreatic cancer heterogeneity and response to Mek inhibition.
Author: Pedersen, K|Bilal, F|Bernado Morales, C|Salcedo, M T|Macarulla, T|Masso-Valles, D|Mohan, V|Vivancos, A|Carreras, M-J|Serres, X|Abu-Suboh, M|Balsells, J|Allende, E|Sagi, I|Soucek, L|Tabernero, J|Arribas, J
PMID: 28581516
156.
Journal: Br J Cancer. 2017 Jul 11;117(2):245-255.
Title: KIF15 promotes pancreatic cancer proliferation via the MEK-ERK signalling pathway.
Author: Wang, Jie|Guo, Xingjun|Xie, Chencheng|Jiang, Jianxin
PMID: 28595260
157.
Journal: Mol Cancer Ther. 2017 Sep;16(9):1729-1738.
Title: Cotargeting of MEK and PDGFR/STAT3 Pathways to Treat Pancreatic Ductal Adenocarcinoma.
Author: Sahu, Nisebita|Chan, Emily|Chu, Felix|Pham, Thinh|Koeppen, Hartmut|Forrest, William|Merchant, Mark|Settleman, Jeff
PMID: 28619758
158.
Journal: Cancer Res. 2017 Aug 15;77(16):4328-4341.
Title: Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction.
Author: Jin, Xin|Pan, Yunqian|Wang, Liguo|Ma, Tao|Zhang, Lizhi|Tang, Amy H|Billadeau, Daniel D|Wu, Heshui|Huang, Haojie
PMID: 28720574
159.
Journal: Cell Rep. 2017 Jul 25;20(4):999-1015.
Title: A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution.
Author: Anderson, Grace R|Winter, Peter S|Lin, Kevin H|Nussbaum, Daniel P|Cakir, Merve|Stein, Elizabeth M|Soderquist, Ryan S|Crawford, Lorin|Leeds, Jim C|Newcomb, Rachel|Stepp, Priya|Yip, Catherine|Wardell, Suzanne E|Tingley, Jennifer P|Ali, Moiez|Xu, Mengmeng|Ry
PMID: 28746882
160.
Journal: PLoS One. 2017 Sep 28;12(9):e0185687.
Title: Molecular subtype specific efficacy of MEK inhibitors in pancreatic cancers.
Author: Brauswetter, Diana|Gurbi, Bianka|Varga, Attila|Varkondi, Edit|Schwab, Richard|Banhegyi, Gabor|Fabian, Orsolya|Keri, Gyorgy|Valyi-Nagy, Istvan|Petak, Istvan
PMID: 28957417
161.
Journal: Sci Rep. 2017 Dec 11;7(1):17313.
Title: Negative regulation of TGF-beta1-induced MKK6-p38 and MEK-ERK signalling and epithelial-mesenchymal transition by Rac1b.
Author: Witte, David|Otterbein, Hannah|Forster, Maria|Giehl, Klaudia|Zeiser, Robert|Lehnert, Hendrik|Ungefroren, Hendrik
PMID: 29229918
162.
Journal: Int J Mol Sci. 2017 Dec 20;18(12). pii: ijms18122776.
Title: The Role of PAR2 in TGF-beta1-Induced ERK Activation and Cell Motility.
Author: Ungefroren, Hendrik|Witte, David|Fiedler, Christian|Gadeken, Thomas|Kaufmann, Roland|Lehnert, Hendrik|Gieseler, Frank|Rauch, Bernhard H
PMID: 29261154
163.
Journal: Postepy Dermatol Alergol. 2017 Oct;34(5):418-428.
Title: The incidence and management of cutaneous adverse events of the epidermal growth factor receptor inhibitors.
Author: Owczarek, Witold|Slowinska, Monika|Lesiak, Aleksandra|Ciazynska, Magdalena|Maciag, Aldona|Paluchowska, Elwira|Marek-Jozefowicz, Luiza|Czajkowski, Rafal
PMID: 29507555
164.
Journal: J Cell Commun Signal. 2018 Jan 29. pii: 10.1007/s12079-017-0444-0.
Title: p38 differentially regulates ERK, p21, and mitogenic signalling in two pancreatic carcinoma cell lines.
Author: Aasrum, Monica|Thoresen, G Hege|Christoffersen, Thoralf|Brusevold, Ingvild J
PMID: 29380233
165.
Journal: Oncotarget. 2017 Dec 25;9(4):5274-5286.
Title: Inhibition of the MEK/ERK pathway augments nab-paclitaxel-based chemotherapy effects in preclinical models of pancreatic cancer.
Author: Awasthi, Niranjan|Monahan, Sheena|Stefaniak, Alexis|Schwarz, Margaret A|Schwarz, Roderich E
PMID: 29435178
166.
Journal: Int J Oncol. 2018 Apr;52(4):1105-1116.
Title: RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling.
Author: Qi, Zi-Hao|Xu, Hua-Xiang|Zhang, Shi-Rong|Xu, Jin-Zhi|Li, Shuo|Gao, He-Li|Jin, Wei|Wang, Wen-Quan|Wu, Chun-Tao|Ni, Quan-Xing|Yu, Xian-Jun|Liu, Liang
PMID: 29436617
167.
Journal: Oncotarget. 2018 Jan 22;9(14):11592-11603.
Title: MEK inhibition leads to BRCA2 downregulation and sensitization to DNA damaging agents in pancreas and ovarian cancer models.
Author: Vena, Francesca|Jia, Ruochen|Esfandiari, Arman|Garcia-Gomez, Juan J|Rodriguez-Justo, Manuel|Ma, Jianguo|Syed, Sakeena|Crowley, Lindsey|Elenbaas, Brian|Goodstal, Samantha|Hartley, John A|Hochhauser, Daniel
PMID: 29545922
168.
Journal: Mol Carcinog. 2018 Sep;57(9):1130-1143.
Title: A novel tricarbonylmethane agent (CMC2.24) reduces human pancreatic tumor growth in mice by targeting Ras.
Author: Mallangada, Naveen A|Vargas, Joselin M|Thomas, Swaroopa|DiGiovanni, Matthew G|Vaeth, Brandon M|Nemesure, Matthew D|Wang, Ruixue|LaComb, Joseph F|Williams, Jennie L|Golub, Lorne M|Johnson, Francis|Mackenzie, Gerardo G
PMID: 29683208
169.
Journal: Biochem Biophys Res Commun. 2018 Jun 12;500(4):873-878.
Title: ROS mediated EGFR/MEK/ERK/HIF-1alpha Loop Regulates Glucose metabolism in pancreatic cancer.
Author: Wang, Gang|Li, Yifeng|Yang, Zeyu|Xu, Weina|Yang, Yifan|Tan, Xiaodong
PMID: 29702094
170.
Journal: Cancers (Basel). 2018 May 14;10(5). pii: cancers10050142.
Title: A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology.
Author: Van Sciver, Robert E|Lee, Michael P|Lee, Caroline Dasom|Lafever, Alex C|Svyatova, Elizaveta|Kanda, Kevin|Colliver, Amber L|Siewertsz van Reesema, Lauren L|Tang-Tan, Angela M|Zheleva, Vasilena|Bwayi, Monicah N|Bian, Minglei|Schmidt, Rebecca L|Matrisian, Ly
PMID: 29757973
171.
Journal: Biochem Biophys Res Commun. 2018 Jun 27;501(3):751-757.
Title: Inhibition of pancreatic cancer Panc1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK.
Author: Jin, Un-Ho|Karki, Keshav|Kim, Sang-Bae|Safe, Stephen
PMID: 29758193
172.
Journal: Tissue Cell. 2018 Jun;52:124-128.
Title: MEK inhibitor trametinib in combination with gemcitabine regresses a patient-derived orthotopic xenograft (PDOX) pancreatic cancer nude mouse model.
Author: Kawaguchi, Kei|Igarashi, Kentaro|Miyake, Kentaro|Lwin, Thinzar M|Miyake, Masuyo|Kiyuna, Tasuku|Hwang, Ho Kyoung|Murakami, Takashi|Delong, Jonathan C|Singh, Shree Ram|Clary, Bryan|Bouvet, Michael|Unno, Michiaki|Hoffman, Robert M
PMID: 29857821
173.
Journal: Cell Cycle. 2018;17(12):1487-1495.
Title: Rapid induction of pancreatic cancer cells to cancer stem cells via heterochromatin modulation.
Author: Xu, Zhengyan|Jia, Yanjun|Huang, Xiaoxi|Feng, Nianhua|Li, Ying
PMID: 30045656
174.
Journal: Cancer Lett. 2018 Sep 11;438:174-186.
Title: KRAS targeting antibody synergizes anti-cancer activity of gemcitabine against pancreatic cancer.
Author: Kang, Yeo Wool|Lee, Ji Eun|Jung, Kyung Hee|Son, Mi Kwon|Shin, Seung-Min|Kim, Soo Jung|Fang, Zhenghuan|Yan, Hong Hua|Park, Jung Hee|Han, Boreum|Cheon, Min Ji|Woo, Min Gyu|Lim, Joo Han|Kim, Yong-Sung|Hong, Soon-Sun
PMID: 30217561
175.
Journal: Oncol Rep. 2018 Nov;40(5):3102-3111.
Title: Tanshinone IIA can inhibit MiaPaCa2 human pancreatic cancer cells by dual blockade of the Ras/Raf/MEK/ERK and PI3K/AKT/mTOR pathways.
Author: Su, Chin-Cheng
PMID: 30226540
176.
Journal: Mol Cancer Ther. 2018 Sep 25. pii: 1535-7163.MCT-18-0082.
Title: Cyclooxygenase-2 Influences Response to Co-Targeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers.
Author: Maust, Joel D|Frankowski-McGregor, Christy L|Bankhead, Armand|Simeone, Diane M|Sebolt-Leopold, Judith S
PMID: 30254182
177.
Journal: Cancer Biol Ther. 2018 Sep 27:1-10.
Title: Combined inhibition of the PI3K/mTOR/MEK pathway induces Bim/Mcl-2-regulated apoptosis in pancreatic cancer cells.
Author: Burmi, Rajpal S|Maginn, Elaina N|Gabra, Hani|Stronach, Euan A|Wasan, Harpreet S
PMID: 30261145
178.
Journal: Cell Cycle. 2018;17(16):1949-1966.
Title: The long coding RNA AFAP1-AS1 promotes tumor cell growth and invasion in pancreatic cancer through upregulating the IGF1R oncogene via sequestration of miR-133a.
Author: Chen, Bo|Li, Qinhua|Zhou, Yongping|Wang, Xujing|Zhang, Qiqi|Wang, Yongkun|Zhuang, Huiren|Jiang, Xiaohua|Xiong, Wujun
PMID: 30300116
179.
Journal: Nat Commun. 2018 Oct 15;9(1):4275.
Title: CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response.
Author: Szlachta, Karol|Kuscu, Cem|Tufan, Turan|Adair, Sara J|Shang, Stephen|Michaels, Alex D|Mullen, Matthew G|Fischer, Natasha Lopes|Yang, Jiekun|Liu, Limin|Trivedi, Prasad|Stelow, Edward B|Stukenberg, P Todd|Parsons, J Thomas|Bauer, Todd W|Adli, Mazhar
PMID: 30323222
180.
Journal: Biomed Pharmacother. 2018 Sep 26;108:925-933.
Title: Isorhamnetin suppresses PANC-1 pancreatic cancer cell proliferation through S phase arrest.
Author: Wang, Jia-Li|Quan, Qinghua|Ji, Ruifang|Guo, Xiao-Yu|Zhang, Jia-Mei|Li, Xia|Liu, Yong-Gang
PMID: 30372904
181.
Journal: Medicine (Baltimore). 2018 Nov;97(44):e12940.
Title: Laparoscopic pancreaticoduodenectomy for metastatic pancreatic melanoma: A case report.
Author: Liu, Xueqing|Feng, Feng|Wang, Tianyang|Qin, Jianzhang|Yin, Xiangyan|Meng, Guiqing|Yan, Changqing|Xing, Zhongqiang|Duan, Jiayue|Liu, Chen|Liu, Jianhua
PMID: 30383642