Literatures

Primary Site >> Colorectal Cancer

Gene >> MAP2K7

1.
Journal:	J Cell Sci. 1998 Apr;111 ( Pt 8):1039-49.
Title:	Modulation of hepatocyte growth factor-induced scattering of HT29 colon carcinoma cells. Involvement of the MAPK pathway.
Author:	Herrera, R
PMID:	9512500

2.
Journal:	Gastroenterology. 1998 Nov;115(5):1144-53.
Title:	Oncogenic ras induces gastrin gene expression in colon cancer.
Author:	Nakata, H\|Wang, S L\|Chung, D C\|Westwick, J K\|Tillotson, L G
PMID:	9797369

3.
Journal:	Oncogene. 1999 Mar 11;18(10):1807-17.
Title:	Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells.
Author:	Plattner, R\|Gupta, S\|Khosravi-Far, R\|Sato, K Y\|Perucho, M\|Der, C J\|Stanbridge, E J
PMID:	10086335

4.
Journal:	Gastroenterology. 1999 May;116(5):1072-80.
Title:	Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation.
Author:	Taupin, D\|Podolsky, D K
PMID:	10220499

5.
Journal:	Mol Med. 1999 Mar;5(3):147-59.
Title:	Glycine-extended gastrin exerts growth-promoting effects on human colon cancer cells.
Author:	Stepan, V M\|Sawada, M\|Todisco, A\|Dickinson, C J
PMID:	10404512

6.
Journal:	Br J Cancer. 1999 Dec;81(7):1116-21.
Title:	Differential regulation of MAP kinase cascade in human colorectal tumorigenesis.
Author:	Park, K S\|Kim, N G\|Kim, J J\|Kim, H\|Ahn, Y H\|Choi, K Y
PMID:	10584870

7.
Journal:	Cancer Res. 2000 Jul 1;60(13):3631-7.
Title:	Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.
Author:	Lee, K\|Deng, X\|Friedman, E
PMID:	10910078

8.
Journal:	Zentralbl Chir. 2000;125 Suppl 1:12-5.
Title:	[Deregulation of intracellular signal pathways in colorectal carcinoma].
Author:	Troppmair, J\|Rapp, U R
PMID:	10929640

9.
Journal:	Oncogene. 2001 Apr 5;20(15):1913-22.
Title:	Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody.
Author:	Liu, B\|Fang, M\|Lu, Y\|Mendelsohn, J\|Fan, Z
PMID:	11313939

10.
Journal:	Bioorg Med Chem Lett. 2001 Jun 4;11(11):1407-10.
Title:	MEK (MAPKK) inhibitors. Part 2: structure-activity relationships of 4-anilino-3-cyano-6,7-dialkoxyquinolines.
Author:	Zhang, N\|Wu, B\|Eudy, N\|Wang, Y\|Ye, F\|Powell, D\|Wissner, A\|Feldberg, L R\|Kim, S C\|Mallon, R\|Kovacs, E D\|Toral-Barza, L\|Kohler, C A
PMID:	11378365

11.
Journal:	Biochem Biophys Res Commun. 2001 Jun 8;284(2):282-8.
Title:	Alterations of MAPK activities associated with intestinal cell differentiation.
Author:	Ding, Q\|Wang, Q\|Evers, B M
PMID:	11394874

12.
Journal:	Neoplasia. 2001 May-Jun;3(3):215-26.
Title:	The protrusive phase and full development of integrin-dependent adhesions in colon epithelial cells require FAK- and ERK-mediated actin spike formation: deregulation in cancer cells.
Author:	Brunton, V G\|Fincham, V J\|McLean, G W\|Winder, S J\|Paraskeva, C\|Marshall, J F\|Frame, M C
PMID:	11494115

13.
Journal:	Oncol Rep. 2001 Nov-Dec;8(6):1409-13.
Title:	Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer.
Author:	Feng, J\|Hua, F\|Shuo, R\|Chongfeng, G\|Huimian, X\|Nakajima, T\|Subao, W\|Tsuchida, N
PMID:	11605075

14.
Journal:	Int J Cancer. 2002 May 20;99(3):323-7.
Title:	The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells.
Author:	Elder, Douglas J E\|Halton, Dawn E\|Playle, Laura C\|Paraskeva, Christos
PMID:	11992399

15.
Journal:	J Biol Chem. 2002 Sep 6;277(36):32624-31. Epub 2002 Jun 20.
Title:	Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B.
Author:	Lee, Hae-Wan\|Ahn, Dae-Ho\|Crawley, Suzanne C\|Li, Jian-Dong\|Gum, James R Jr\|Basbaum, Carol B\|Fan, Nancy Q\|Szymkowski, David E\|Han, Sang-Young\|Lee, Bong H\|Sleisenger, Marvin H\|Kim, Young S
PMID:	12077118

16.
Journal:	Br Med Bull. 2002;64:227-54.
Title:	Therapeutics targeting signal transduction for patients with colorectal carcinoma.
Author:	de Bono, Johann S\|Rowinsky, Eric K
PMID:	12421735

17.
Journal:	J Lab Clin Med. 2003 May;141(5):335-41.
Title:	Oncogenic ras induces gastrin/CCKB receptor gene expression in human colon cancer cell lines LoVo and Colo320HSR.
Author:	Hori, Hiroyuki\|Nakata, Hirohisa\|Iguchi, Genzo\|Yamada, Hajime\|Chihara, Kazuo\|Baba, Hisamitsu
PMID:	12761477

18.
Journal:	Life Sci. 2003 Oct 17;73(22):2817-29.
Title:	MAP kinase-mediated proliferation of DLD-1 carcinoma by the stimulation of protease-activated receptor 2.
Author:	Jikuhara, Atsushi\|Yoshii, Masanori\|Iwagaki, Hiromi\|Mori, Shuji\|Nishibori, Masahiro\|Tanaka, Noriaki
PMID:	14511767

19.
Journal:	Cancer Sci. 2003 Oct;94(10):886-93.
Title:	Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine.
Author:	Aizawa, Shu\|Ookawa, Keizou\|Kudo, Toshihiro\|Asano, Junpei\|Hayakari, Makoto\|Tsuchida, Shigeki
PMID:	14556662

20.
Journal:	Gastroenterology. 2004 Jan;126(1):8-18.
Title:	Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling.
Author:	Thamilselvan, Vijayalakshmi\|Basson, Marc D
PMID:	14699482

21.
Journal:	Oncogene. 2004 Mar 11;23(10):1885-95.
Title:	Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway.
Author:	Wang, Xiaofu\|Wang, Qingding\|Hu, Wanqin\|Evers, B Mark
PMID:	14981539

22.
Journal:	J Pathol. 2004 Mar;202(3):336-40.
Title:	In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours.
Author:	Sieben, Nathalie L G\|Macropoulos, Patricia\|Roemen, Guido M J M\|Kolkman-Uljee, Sandra M\|Jan Fleuren, Gert\|Houmadi, Rifat\|Diss, Tim\|Warren, Bretta\|Al Adnani, Mudher\|De Goeij, Anton P M\|Krausz, Thomas\|Flanagan, Adrienne M
PMID:	14991899

23.
Journal:	J Biol Chem. 2004 Oct 1;279(40):41377-83.
Title:	Protein phosphatase 2A, a negative regulator of the ERK signaling pathway, is activated by tyrosine phosphorylation of putative HLA class II-associated protein I (PHAPI)/pp32 in response to the antiproliferative lectin, jacalin.
Author:	Yu, Lu-Gang\|Packman, Len C\|Weldon, Mike\|Hamlett, Jane\|Rhodes, Jonathan M
PMID:	15247276

24.
Journal:	Biochem Biophys Res Commun. 2004 Sep 17;322(2):609-13.
Title:	Susceptibility to cell death induced by blockade of MAPK pathway in human colorectal cancer cells carrying Ras mutations is dependent on p53 status.
Author:	Wang, Zhen\|Li, Yuqing\|Liu, Edison T\|Yu, Qiang
PMID:	15325273

25.
Journal:	Oncogene. 2004 Oct 7;23(46):7712-21.
Title:	Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells.
Author:	Shi, Ran-Xin\|Ong, Choon-Nam\|Shen, Han-Ming
PMID:	15334063

26.
Journal:	J Clin Oncol. 2004 Nov 15;22(22):4456-62. Epub 2004 Oct 13.
Title:	Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer.
Author:	Rinehart, John\|Adjei, Alex A\|Lorusso, Patricia M\|Waterhouse, David\|Hecht, J Randolph\|Natale, Ronald B\|Hamid, Oday\|Varterasian, Mary\|Asbury, Peggy\|Kaldjian, Eric P\|Gulyas, Stephen\|Mitchell, David Y\|Herrera, Roman\|Sebolt-Leopold, Judith S\|Meyer, Mark B
PMID:	15483017

27.
Journal:	Pharm Res. 2004 Sep;21(9):1670-9.
Title:	In vitro and in vivo metabolism of the anti-cancer agent CI-1040, a MEK inhibitor, in rat, monkey, and human.
Author:	Wabnitz, Paul A\|Mitchell, David\|Wabnitz, David A M
PMID:	15497695

28.
Journal:	Cancer Res. 2004 Nov 15;64(22):8148-51.
Title:	Inhibition of extracellular-signal regulated kinases 1/2 is required for apoptosis of human colon cancer cells in vitro by sulindac metabolites.
Author:	Rice, Pamela L\|Beard, K Scott\|Driggers, Linda J\|Ahnen, Dennis J
PMID:	15548677

29.
Journal:	Blood. 2005 Feb 15;105(4):1734-41. Epub 2004 Oct 19.
Title:	Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis.
Author:	Yu, Joanne L\|May, Linda\|Lhotak, Vladimir\|Shahrzad, Siranoush\|Shirasawa, Senji\|Weitz, Jeffrey I\|Coomber, Brenda L\|Mackman, Nigel\|Rak, Janusz W
PMID:	15494427

30.
Journal:	Carcinogenesis. 2005 Jan;26(1):109-17.
Title:	Selenomethionine induces sustained ERK phosphorylation leading to cell-cycle arrest in human colon cancer cells.
Author:	Goulet, Anne-Christine\|Chigbrow, Marianne\|Frisk, Peter\|Nelson, Mark A
PMID:	15513932

31.
Journal:	Cancer Chemother Pharmacol. 2005 Apr;55(4):369-78. Epub 2004 Nov 5.
Title:	Quinoxaline 1,4-dioxides induce G2/M cell cycle arrest and apoptosis in human colon cancer cells.
Author:	Gali-Muhtasib, Hala U\|Diab-Assaf, Mona\|Haddadin, Makhluf J
PMID:	15538569

32.
Journal:	J Cell Physiol. 2005 Jul;204(1):36-44.
Title:	Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor.
Author:	Sainaghi, Pier Paolo\|Castello, Luigi\|Bergamasco, Luca\|Galletti, Margherita\|Bellosta, Paola\|Avanzi, Gian Carlo
PMID:	15605394

33.
Journal:	J Pharmacol Sci. 2005 Jan;97(1):25-30. Epub 2005 Jan 15.
Title:	Physiology and pathophysiology of proteinase-activated receptors (PARs): PAR-2-mediated proliferation of colon cancer cell.
Author:	Nishibori, Masahiro\|Mori, Shuji\|Takahashi, Hideo K
PMID:	15655297

34.
Journal:	Anticancer Drugs. 2005 Feb;16(2):129-36.
Title:	The Raf kinase inhibitor BAY 43-9006 reduces cellular uptake of platinum compounds and cytotoxicity in human colorectal carcinoma cell lines.
Author:	Heim, Martina\|Scharifi, Mariam\|Zisowsky, Jochen\|Jaehde, Ulrich\|Voliotis, Dimitris\|Seeber, Siegfried\|Strumberg, Dirk
PMID:	15655409

35.
Journal:	Mol Cancer Ther. 2005 Jan;4(1):51-9.
Title:	Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells.
Author:	Sun, Yunjie\|Sinicrope, Frank A
PMID:	15657353

36.
Journal:	Int J Cancer. 2005 Jul 10;115(5):673-7.
Title:	Mutations of the BRAF gene in ulcerative colitis-related colorectal carcinoma.
Author:	Aust, Daniela E\|Haase, Michael\|Dobryden, Lyudmyla\|Markwarth, Annett\|Lohrs, Udo\|Wittekind, Christian\|Baretton, Gustavo B\|Tannapfel, Andrea
PMID:	15704157

37.
Journal:	Int J Cancer. 2005 Jul 20;115(6):943-50.
Title:	BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms.
Author:	Ikehara, Nobunao\|Semba, Shuho\|Sakashita, Masanori\|Aoyama, Nobuo\|Kasuga, Masato\|Yokozaki, Hiroshi
PMID:	15729718

38.
Journal:	Cytokine. 2005 Mar 21;29(6):275-82.
Title:	IL-8 promotes cell proliferation and migration through metalloproteinase-cleavage proHB-EGF in human colon carcinoma cells.
Author:	Itoh, Yusuke\|Joh, Takashi\|Tanida, Satoshi\|Sasaki, Makoto\|Kataoka, Hiromi\|Itoh, Keisuke\|Oshima, Tadayuki\|Ogasawara, Naotaka\|Togawa, Shouzo\|Wada, Tsuneya\|Kubota, Hidetsugu\|Mori, Yoshinori\|Ohara, Hirotaka\|Nomura, Tomoyuki\|Higashiyama, Shigeki\|Itoh, Makoto
PMID:	15749028

39.
Journal:	J Biol Chem. 2005 Jun 17;280(24):22856-67.
Title:	Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway.
Author:	Drosopoulos, Konstantinos G\|Roberts, Michael L\|Cermak, Lukas\|Sasazuki, Takehiko\|Shirasawa, Senji\|Andera, Ladislav\|Pintzas, Alexander
PMID:	15757891

40.
Journal:	Dig Dis Sci. 2005 Mar;50(3):490-8.
Title:	Butyrate-induced differentiation of colon cancer cells is PKC and JNK dependent.
Author:	Orchel, Arkadiusz\|Dzierzewicz, Zofia\|Parfiniewicz, Beata\|Weglarz, Ludmila\|Wilczok, Tadeusz
PMID:	15810631

41.
Journal:	Mol Pharmacol. 2005 Aug;68(2):477-86.
Title:	Characterization of a human carcinoma cell line selected for resistance to the farnesyl transferase inhibitor 4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-b)-pyri din-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxami
Author:	Bruzek, Laura M\|Poynter, Jenny N\|Kaufmann, Scott H\|Adjei, Alex A
PMID:	15901852

42.
Journal:	Cancer Res. 2005 Jul 15;65(14):6380-7.
Title:	Identification of a novel synthetic thiazolidin compound capable of inducing c-Jun NH2-terminal kinase-dependent apoptosis in human colon cancer cells.
Author:	Teraishi, Fuminori\|Wu, Shuhong\|Zhang, Lidong\|Guo, Wei\|Davis, John J\|Dong, Fengqin\|Fang, Bingliang
PMID:	16024641

43.
Journal:	J Physiol Pharmacol. 2005 Jun;56 Suppl 3:119-41.
Title:	Position of STAT-1 alpha in cycloheximide-dependent apoptosis triggered by TNF-alpha in human colorectal COLO 205 cancer cell line; role of polyphenolic compounds.
Author:	Pajak, B\|Gajkowska, B\|Orzechowski, A
PMID:	16077199

44.
Journal:	J Pharmacol Sci. 2005 Aug;98(4):450-8. Epub 2005 Aug 10.
Title:	Mast cell tryptase stimulates DLD-1 carcinoma through prostaglandin- and MAP kinase-dependent manners.
Author:	Yoshii, Masanori\|Jikuhara, Atsushi\|Mori, Shuji\|Iwagaki, Hiromi\|Takahashi, Hideo K\|Nishibori, Masahiro\|Tanaka, Noriaki
PMID:	16093613

45.
Journal:	Oncogene. 2006 Jan 5;25(1):43-50.
Title:	Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase.
Author:	Wang, Q\|Zhou, Y\|Wang, X\|Evers, B M
PMID:	16278684

46.
Journal:	Oncogene. 2006 Mar 16;25(12):1743-52.
Title:	The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells overexpressing MRP1.
Author:	Abdul-Ghani, R\|Serra, V\|Gyorffy, B\|Jurchott, K\|Solf, A\|Dietel, M\|Schafer, R
PMID:	16288223

47.
Journal:	J Cell Sci. 2006 Mar 1;119(Pt 5):819-27. Epub 2006 Feb 14.
Title:	APC inhibits ERK pathway activation and cellular proliferation induced by RAS.
Author:	Park, Ki-Sook\|Jeon, Soung Hoo\|Kim, Sung-Eun\|Bahk, Young-Yil\|Holmen, Sheri L\|Williams, Bart O\|Chung, Kwang-Chul\|Surh, Young-Joon\|Choi, Kang-Yell
PMID:	16478791

48.
Journal:	Cell Death Differ. 2006 Nov;13(11):1982-93.
Title:	Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis.
Author:	Lin, L\|Su, Z\|Lebedeva, I V\|Gupta, P\|Boukerche, H\|Rai, T\|Barber, G N\|Dent, P\|Sarkar, D\|Fisher, P B
PMID:	16575407

49.
Journal:	Oncogene. 2006 Sep 14;25(41):5640-7. Epub 2006 Apr 17.
Title:	Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling.
Author:	Liu, Y\|Borchert, G L\|Surazynski, A\|Hu, C-A\|Phang, J M
PMID:	16619034

50.
Journal:	Exp Cell Res. 2006 Jul 15;312(12):2203-13.
Title:	Requirement of the enzymatic and signaling activities of plasmin for phorbol-ester-induced scattering of colon cancer cells.
Author:	Diaz, Victor M\|Hurtado, Mariano\|Kort, Eric J\|Resnati, Massimo\|Blasi, Francesco\|Thomson, Timothy\|Paciucci, Rosanna
PMID:	16631161

51.
Journal:	Anticancer Drugs. 2006 Jun;17(5):553-8.
Title:	Octahedral Pt(IV) complex K101 induces apoptosis via ERK1/2 activation and the p53 pathway in human colon cancer cells.
Author:	Kwon, Young-Ee\|Kim, Kuk-Hwan
PMID:	16702812

52.
Journal:	Ai Zheng. 2006 Jun;25(6):683-8.
Title:	[Role of calcium signal in apoptosis and protective mechanism of colon cancer cell line SW480 in response to 5-aminolevulinic acid-photodynamic therapy].
Author:	Zheng, Jiang-Hua\|Shi, De\|Zhao, Yu\|Chen, Zu-Lin
PMID:	16764761

53.
Journal:	Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14122-7. Epub 2006 Sep 7.
Title:	Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.
Author:	Sansom, Owen J\|Meniel, Valerie\|Wilkins, Julie A\|Cole, Alicia M\|Oien, Karin A\|Marsh, Victoria\|Jamieson, Thomas J\|Guerra, Carmen\|Ashton, Gabrielle H\|Barbacid, Mariano\|Clarke, Alan R
PMID:	16959882

54.
Journal:	Mol Cancer. 2006 Nov 17;5:63.
Title:	Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells.
Author:	Komatsu, Koga\|Buchanan, F Gregory\|Otaka, Michiro\|Jin, Mario\|Odashima, Masaru\|Horikawa, Yohei\|Watanabe, Sumio\|Dubois, Raymond N
PMID:	17112382

55.
Journal:	FEBS Lett. 2006 Dec 11;580(28-29):6565-9.
Title:	Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells.
Author:	Vaculova, Alena\|Hofmanova, Jirina\|Soucek, Karel\|Kozubik, Alois
PMID:	17113582

56.
Journal:	Endocr Regul. 2006 Dec;40(4):129-38.
Title:	BRAF mutations in papillary thyroid carcinoma.
Author:	Wojciechowska, Katarzyna\|Lewinski, Andrzej
PMID:	17201587

57.
Journal:	Biochem Biophys Res Commun. 2007 May 11;356(3):599-603. Epub 2007 Mar 12.
Title:	The short chain fatty acid, butyrate, stimulates MUC2 mucin production in the human colon cancer cell line, LS174T.
Author:	Hatayama, Hajime\|Iwashita, Jun\|Kuwajima, Akiko\|Abe, Tatsuya
PMID:	17374366

58.
Journal:	Cancer. 2007 May 15;109(10):1996-2003.
Title:	XAF1 mediates apoptosis through an extracellular signal-regulated kinase pathway in colon cancer.
Author:	Yu, Li Fen\|Wang, Jide\|Zou, Bing\|Lin, Marie C M\|Wu, Yun Lin\|Xia, Harry H X\|Sun, Yun Wei\|Gu, Qing\|He, Hua\|Lam, S K\|Kung, Hsiang Fu\|Wong, Benjamin C Y
PMID:	17385215

59.
Journal:	Int J Biol Markers. 2007 Jan-Mar;22(1):12-8.
Title:	Highly conserved sequence of exon 15 BRAF gene and KRAS codon 12 mutation among Greek patients with colorectal cancer.
Author:	Symvoulakis, E K\|Zaravinos, A\|Panutsopulos, D\|Zoras, O\|Papalambros, E\|Sigala, F\|Spandidos, D A
PMID:	17393356

60.
Journal:	Chin Med J (Engl). 2007 May 5;120(9):743-8.
Title:	Inducing effects of hepatocyte growth factor on the expression of vascular endothelial growth factor in human colorectal carcinoma cells through MEK and PI3K signaling pathways.
Author:	Zhang, Yu-hua\|Wei, Wei\|Xu, Hao\|Wang, Yan-yan\|Wu, Wen-xi
PMID:	17531111

61.
Journal:	Gut. 2007 Nov;56(11):1557-63. Epub 2007 Jun 29.
Title:	Synergistic effects of RXR alpha and PPAR gamma ligands to inhibit growth in human colon cancer cells--phosphorylated RXR alpha is a critical target for colon cancer management.
Author:	Yamazaki, Kenji\|Shimizu, Masahito\|Okuno, Masataka\|Matsushima-Nishiwaki, Rie\|Kanemura, Nobuhiro\|Araki, Hiroshi\|Tsurumi, Hisashi\|Kojima, Soichi\|Weinstein, I Bernard\|Moriwaki, Hisataka
PMID:	17604322

62.
Journal:	Mol Cancer Ther. 2007 Jul;6(7):2092-102.
Title:	Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein.
Author:	Katayama, Kazuhiro\|Yoshioka, Sho\|Tsukahara, Satomi\|Mitsuhashi, Junko\|Sugimoto, Yoshikazu
PMID:	17620438

63.
Journal:	Zhonghua Yi Xue Za Zhi. 2007 Apr 10;87(14):982-6.
Title:	[Effects of extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway activation on proliferation and cell cycle associated genes in human colon cancer cells].
Author:	Wang, Xia\|Lu, Rong\|Fang, Jing-yuan
PMID:	17650425

64.
Journal:	Mol Cancer Ther. 2007 Aug;6(8):2220-9.
Title:	Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth.
Author:	Hao, Honglin\|Muniz-Medina, Vanessa M\|Mehta, Heena\|Thomas, Nancy E\|Khazak, Vladimir\|Der, Channing J\|Shields, Janiel M
PMID:	17699719

65.
Journal:	Exp Mol Pathol. 2007 Dec;83(3):443-52.
Title:	Keratinocyte growth factor-transfection-stimulated adhesion of colorectal cancer cells to extracellular matrices.
Author:	Kudo, Mitsuhiro\|Ishiwata, Toshiyuki\|Nakazawa, Nando\|Kawahara, Kiyoko\|Fujii, Takenori\|Teduka, Kiyoshi\|Naito, Zenya
PMID:	17706640

66.
Journal:	Cancer Res. 2007 Oct 1;67(19):9286-93.
Title:	Nitric oxide inactivates the retinoblastoma pathway in chronic inflammation.
Author:	Ying, Lei\|Hofseth, Anne B\|Browning, Darren D\|Nagarkatti, Mitzi\|Nagarkatti, Prakash S\|Hofseth, Lorne J
PMID:	17909036

67.
Journal:	ChemMedChem. 2007 Dec;2(12):1789-98.
Title:	Alkoxymethylenephosphonate analogues of (Lyso) phosphatidic acid stimulate signaling networks coupled to the LPA2 receptor.
Author:	Gajewiak, Joanna\|Tsukahara, Ryoko\|Tsukahara, Tamotsu\|Fujiwara, Yuko\|Yu, Shuanxing\|Lu, Yiling\|Murph, Mandi\|Mills, Gordon B\|Tigyi, Gabor\|Prestwich, Glenn D
PMID:	17952880

68.
Journal:	Rev Recent Clin Trials. 2007 May;2(2):121-34.
Title:	Therapeutic strategies for targeting BRAF in human cancer.
Author:	Pratilas, Christine A\|Solit, David B
PMID:	18473997

69.
Journal:	Gastroenterology. 2008 Jan;134(1):120-30. Epub 2007 Oct 17.
Title:	Kruppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis.
Author:	Nandan, Mandayam O\|McConnell, Beth B\|Ghaleb, Amr M\|Bialkowska, Agnieszka B\|Sheng, Hongmiao\|Shao, Jinyi\|Babbin, Brian A\|Robine, Sylvie\|Yang, Vincent W
PMID:	18054006

70.
Journal:	Mol Cell Biol. 2008 Mar;28(6):1999-2010.
Title:	Regulation of MDMX expression by mitogenic signaling.
Author:	Gilkes, Daniele M\|Pan, Yu\|Coppola, Domenico\|Yeatman, Timothy\|Reuther, Gary W\|Chen, Jiandong
PMID:	18172009

71.
Journal:	Oncol Rep. 2008 Feb;19(2):567-73.
Title:	Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers.
Author:	Hofmanova, Jirina\|Vaculova, Alena\|Hyzd'alova, Martina\|Kozubik, Alois
PMID:	18202809

72.
Journal:	J Biol Chem. 2008 Apr 25;283(17):11565-74.
Title:	A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization.
Author:	Wang, Chunmei\|Li, Nan\|Liu, Xingguang\|Zheng, Yuanyuan\|Cao, Xuetao
PMID:	18305109

73.
Journal:	Nat Genet. 2008 May;40(5):600-8.
Title:	Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.
Author:	Haigis, Kevin M\|Kendall, Krystle R\|Wang, Yufang\|Cheung, Ann\|Haigis, Marcia C\|Glickman, Jonathan N\|Niwa-Kawakita, Michiko\|Sweet-Cordero, Alejandro\|Sebolt-Leopold, Judith\|Shannon, Kevin M\|Settleman, Jeffrey\|Giovannini, Marco\|Jacks, Tyler
PMID:	18372904

74.
Journal:	J Clin Pathol. 2008 Apr;61(4):524-9.
Title:	Raf kinase inhibitor protein: mechanism of loss of expression and association with genomic instability.
Author:	Al-Mulla, F\|Hagan, S\|Al-Ali, W\|Jacob, S P\|Behbehani, A I\|Bitar, M S\|Dallol, A\|Kolch, W
PMID:	18375747

75.
Journal:	Curr Med Chem. 2008;15(10):978-90.
Title:	ANTI-ADHESION evolves to a promising therapeutic concept in oncology.
Author:	Schmidmaier, R\|Baumann, P
PMID:	18393855

76.
Journal:	Mol Pharmacol. 2008 Jul;74(1):246-54.
Title:	Disruption of signaling through SEK1 and MKK7 yields differential responses in hypoxic colon cancer cells treated with oxaliplatin.
Author:	Vasilevskaya, Irina A\|Selvakumaran, Muthu\|O'Dwyer, Peter J
PMID:	18436711

77.
Journal:	Oncogene. 2008 Aug 21;27(36):4921-32.
Title:	Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6.
Author:	Adachi, Y\|Shibai, Y\|Mitsushita, J\|Shang, W H\|Hirose, K\|Kamata, T
PMID:	18454176

78.
Journal:	J Biol Chem. 2008 Oct 10;283(41):27612-9.
Title:	Alpha2beta1 integrin regulates lineage commitment in multipotent human colorectal cancer cells.
Author:	Kirkland, Susan C\|Ying, Huijun
PMID:	18664572

79.
Journal:	Oncogene. 2008 Dec 4;27(57):7150-61.
Title:	Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM.
Author:	Wickenden, J A\|Jin, H\|Johnson, M\|Gillings, A S\|Newson, C\|Austin, M\|Chell, S D\|Balmanno, K\|Pritchard, C A\|Cook, S J
PMID:	18806830

80.
Journal:	Biochem Biophys Res Commun. 2008 Dec 12;377(2):622-6.
Title:	PAR2 triggers IL-8 release via MEK/ERK and PI3-kinase/Akt pathways in GI epithelial cells.
Author:	Tanaka, Yusuke\|Sekiguchi, Fumiko\|Hong, Hao\|Kawabata, Atsufumi
PMID:	18854173

81.
Journal:	J Nutr Biochem. 2009 Feb;20(2):106-14.
Title:	Docosahexaenoic acid induces apoptosis in colorectal carcinoma cells by modulating the PI3 kinase and p38 MAPK pathways.
Author:	Toit-Kohn, Joe-Lin du\|Louw, Louise\|Engelbrecht, Anna-Mart
PMID:	18479896

82.
Journal:	Cell Death Differ. 2009 Mar;16(3):368-77.
Title:	Tumour cell survival signalling by the ERK1/2 pathway.
Author:	Balmanno, K\|Cook, S J
PMID:	18846109

83.
Journal:	Mol Cell Biochem. 2009 Aug;328(1-2):201-8.
Title:	MAP kinases in proliferating human colon cancer Caco-2 cells.
Author:	Buzzi, Natalia\|Colicheo, Andrea\|Boland, Ricardo\|de Boland, Ana Russo
PMID:	19301097

84.
Journal:	Anticancer Res. 2009 Jan;29(1):261-70.
Title:	Enhancement of paclitaxel-induced apoptosis by inhibition of mitogen-activated protein kinase pathway in colon cancer cells.
Author:	Xu, Rui\|Sato, Norihiro\|Yanai, Kosuke\|Akiyoshi, Takashi\|Nagai, Shuntaro\|Wada, Junji\|Koga, Kenichio\|Mibu, Ryuichi\|Nakamura, Masafumi\|Katano, Mitsuo
PMID:	19331159

85.
Journal:	Mol Cancer Ther. 2009 Apr;8(4):834-43.
Title:	KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer.
Author:	Yeh, Jen Jen\|Routh, Elizabeth D\|Rubinas, Tara\|Peacock, Janie\|Martin, Timothy D\|Shen, Xiang Jun\|Sandler, Robert S\|Kim, Hong Jin\|Keku, Temitope O\|Der, Channing J
PMID:	19372556

86.
Journal:	J Pathol. 2009 Aug;218(4):514-9.
Title:	Quantitative cell signalling analysis reveals down-regulation of MAPK pathway activation in colorectal cancer.
Author:	Gulmann, Christian\|Sheehan, Katherine M\|Conroy, Ronan M\|Wulfkuhle, Julia D\|Espina, Virginia\|Mullarkey, Michelle J\|Kay, Elaine W\|Liotta, Lance A\|Petricoin, Emanuel F 3rd
PMID:	19396842

87.
Journal:	IUBMB Life. 2009 Jun;61(6):685-92.
Title:	Tax1 enhances cancer cell proliferation via Ras-Raf-MEK-ERK signaling pathway.
Author:	Song, Chunjiao\|Wang, Weimin\|Li, Meng\|Liu, Yanxin\|Zheng, Dexian
PMID:	19472191

88.
Journal:	Gut. 2009 Sep;58(9):1234-41.
Title:	Concomitant mutations and splice variants in KRAS and BRAF demonstrate complex perturbation of the Ras/Raf signalling pathway in advanced colorectal cancer.
Author:	Seth, R\|Crook, S\|Ibrahem, S\|Fadhil, W\|Jackson, D\|Ilyas, M
PMID:	19474002

89.
Journal:	Anticancer Drugs. 2009 Aug;20(7):601-6.
Title:	Inhibition of MEK sensitizes paclitaxel-induced apoptosis of human colorectal cancer cells by downregulation of GRP78.
Author:	Mhaidat, Nizar M\|Alali, Feras Q\|Matalqah, Sina M\|Matalka, Ismail I\|Jaradat, Saied A\|Al-Sawalha, Nour A\|Thorne, Rick F
PMID:	19521235

90.
Journal:	Int J Cancer. 2009 Oct 1;125(7):1626-39.
Title:	Down-regulation of HLA Class I and NKG2D ligands through a concerted action of MAPK and DNA methyltransferases in colorectal cancer cells.
Author:	Sers, Christine\|Kuner, Ruprecht\|Falk, Christine S\|Lund, Per\|Sueltmann, Holger\|Braun, Monika\|Buness, Andreas\|Ruschhaupt, Markus\|Conrad, Janine\|Mang-Fatehi, Shila\|Stelniec, Iwona\|Krapfenbauer, Ulf\|Poustka, Annemarie\|Schafer, Reinhold
PMID:	19569244

91.
Journal:	Biochem Biophys Res Commun. 2009 Sep 25;387(3):521-4.
Title:	Carbachol induces p70S6K1 activation through an ERK-dependent but Akt-independent pathway in human colonic epithelial cells.
Author:	Jiang, Xiaohua\|Sinnett-Smith, James\|Rozengurt, Enrique
PMID:	19615971

92.
Journal:	Int J Cancer. 2009 Nov 15;125(10):2332-41.
Title:	Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines.
Author:	Balmanno, Kathryn\|Chell, Simon D\|Gillings, Annette S\|Hayat, Shaista\|Cook, Simon J
PMID:	19637312

93.
Journal:	Carcinogenesis. 2009 Oct;30(10):1796-804.
Title:	HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells.
Author:	Moore, Amy E\|Greenhough, Alexander\|Roberts, Heather R\|Hicks, Diane J\|Patsos, Helena A\|Williams, Ann C\|Paraskeva, Christos
PMID:	19638428

94.
Journal:	Mol Cancer Res. 2009 Aug;7(8):1390-8.
Title:	Up-regulation of Kruppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha.
Author:	Mori, Akira\|Moser, Christian\|Lang, Sven A\|Hackl, Christina\|Gottfried, Eva\|Kreutz, Marina\|Schlitt, Hans J\|Geissler, Edward K\|Stoeltzing, Oliver
PMID:	19671674

95.
Journal:	Cell Signal. 2009 Dec;21(12):1846-56.
Title:	Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway.
Author:	Krueger, Felix\|Madeja, Zofia\|Hemberger, Myriam\|McMahon, Martin\|Cook, Simon J\|Gaunt, Stephen J
PMID:	19686845

96.
Journal:	Cancer Res. 2009 Nov 1;69(21):8499-506.
Title:	Oncogenic KRAS and BRAF differentially regulate hypoxia-inducible factor-1alpha and -2alpha in colon cancer.
Author:	Kikuchi, Hirotoshi\|Pino, Maria S\|Zeng, Min\|Shirasawa, Senji\|Chung, Daniel C
PMID:	19843849

97.
Journal:	BMC Cancer. 2009 Dec 12;9:435.
Title:	Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway.
Author:	Tseng, Ya-Shih\|Lee, Jenq-Chang\|Huang, Chi-Ying F\|Liu, Hsiao-Sheng
PMID:	20003375

98.
Journal:	Phytomedicine. 2010 Mar;17(3-4):261-8.
Title:	Role of cyclin inhibitor protein p21 in the inhibition of HCT116 human colon cancer cell proliferation by American ginseng (Panax quinquefolius) and its constituents.
Author:	King, M L\|Murphy, L L
PMID:	19674880

99.
Journal:	Int J Cancer. 2010 Feb 15;126(4):864-75.
Title:	CCK2 receptor expression transforms non-tumorigenic human NCM356 colonic epithelial cells into tumor forming cells.
Author:	Chao, Celia\|Han, Xueliang\|Ives, Kirk\|Park, Jeseong\|Kolokoltsov, Andrey A\|Davey, Robert A\|Moyer, Mary P\|Hellmich, Mark R
PMID:	19697327

100.
Journal:	J Cell Mol Med. 2010 Jun;14(6B):1520-31.
Title:	Translational up-regulation of Aurora-A in EGFR-overexpressed cancer.
Author:	Lai, Chien-Hsien\|Tseng, Joseph T\|Lee, Yi-Chao\|Chen, Ying-Ju\|Lee, Jeng-Chang\|Lin, Bo-Wen\|Huang, Tai-Chien\|Liu, Yao-Wen\|Leu, Tzeng-Horng\|Liu, Yi-Wen\|Chen, Ya-Ping\|Chang, Wen-Chang\|Hung, Liang-Yi
PMID:	19799648

101.
Journal:	Cancer Lett. 2010 Apr 1;290(1):24-35.
Title:	Geldanamycin and its anti-cancer activities.
Author:	Fukuyo, Yayoi\|Hunt, Clayton R\|Horikoshi, Nobuo
PMID:	19850405

102.
Journal:	Mol Cancer Ther. 2010 Jan;9(1):134-44.
Title:	Preclinical in vivo evaluation of efficacy, pharmacokinetics, and pharmacodynamics of a novel MEK1/2 kinase inhibitor RO5068760 in multiple tumor models.
Author:	Daouti, Sherif\|Higgins, Brian\|Kolinsky, Kenneth\|Packman, Kathryn\|Wang, Huisheng\|Rizzo, Christine\|Moliterni, John\|Huby, Nicholas\|Fotouhi, Nader\|Liu, Mei\|Goelzer, Petra\|Sandhu, Harpreet K\|Li, Jia Kui\|Railkar, Aruna\|Heimbrook, David\|Niu, Huifeng
PMID:	20053779

103.
Journal:	Mol Cancer. 2010 Feb 19;9:39.
Title:	Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks.
Author:	Tabu, Kouichi\|Kimura, Taichi\|Sasai, Ken\|Wang, Lei\|Bizen, Norihisa\|Nishihara, Hiroshi\|Taga, Tetsuya\|Tanaka, Shinya
PMID:	20167130

104.
Journal:	Cell Commun Signal. 2010 Feb 2;8(1):1.
Title:	High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cells.
Author:	Kress, Theresia R\|Raabe, Thomas\|Feller, Stephan M
PMID:	20181064

105.
Journal:	Oncogene. 2010 Jun 10;29(23):3398-410.
Title:	The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE(2) signalling in colorectal adenoma cells.
Author:	Greenhough, A\|Wallam, C A\|Hicks, D J\|Moorghen, M\|Williams, A C\|Paraskeva, C
PMID:	20348947

106.
Journal:	J Biol Chem. 2010 Jun 18;285(25):19235-45.
Title:	Induction of the apoptosis inhibitor ARC by Ras in human cancers.
Author:	Wu, Lily\|Nam, Young-Jae\|Kung, Gloria\|Crow, Michael T\|Kitsis, Richard N
PMID:	20392691

107.
Journal:	Cell Oncol. 2010 Jan 1;32(4):245-57.
Title:	Oncogenic K-ras activates p38 to maintain colorectal cancer cell proliferation during MEK inhibition.
Author:	van Houdt, Winan J\|de Bruijn, Menno T\|Emmink, Benjamin L\|Raats, Danielle\|Hoogwater, Frederik J H\|Borel Rinkes, Inne H M\|Kranenburg, Onno
PMID:	20413844

108.
Journal:	Biomed Pharmacother. 2010 Nov;64(9):583-8.
Title:	GABA-receptor agonist, propofol inhibits invasion of colon carcinoma cells.
Author:	Miao, Yufeng\|Zhang, Youwei\|Wan, Haijun\|Chen, Longbang\|Wang, Fangyu
PMID:	20888181

109.
Journal:	Mol Cancer Ther. 2010 Dec;9(12):3351-62.
Title:	Identification of predictive markers of response to the MEK1/2 inhibitor selumetinib (AZD6244) in K-ras-mutated colorectal cancer.
Author:	Tentler, John J\|Nallapareddy, Sujatha\|Tan, Aik Choon\|Spreafico, Anna\|Pitts, Todd M\|Morelli, M Pia\|Selby, Heather M\|Kachaeva, Maria I\|Flanigan, Sara A\|Kulikowski, Gillian N\|Leong, Stephen\|Arcaroli, John J\|Messersmith, Wells A\|Eckhardt, S Gail
PMID:	20923857

110.
Journal:	Mol Cancer. 2010 Oct 13;9:271.
Title:	The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis.
Author:	Bergeron, Sebastien\|Lemieux, Etienne\|Durand, Veronique\|Cagnol, Sebastien\|Carrier, Julie C\|Lussier, Jacques G\|Boucher, Marie-Josee\|Rivard, Nathalie
PMID:	20942929

111.
Journal:	Mol Cancer Res. 2010 Dec;8(12):1579-90.
Title:	FMNL2 enhances invasion of colorectal carcinoma by inducing epithelial-mesenchymal transition.
Author:	Li, Yufa\|Zhu, Xiling\|Zeng, Yuanfeng\|Wang, Jianmei\|Zhang, Xiaojing\|Ding, Yan-qing\|Liang, Li
PMID:	21071512

112.
Journal:	Pharmacology. 2010;86(5-6):313-9.
Title:	Pifithrin-alpha, an inhibitor of p53 transactivation, up-regulates COX-2 expression through an MAPK-dependent pathway.
Author:	Kim, Sangmin\|Han, Jeonghun\|Lee, Se Kyung\|Hur, Sung Mo\|Koo, Minyoung\|Cho, Dong Hui\|Bae, Soo Youn\|Choi, Min-Young\|Shin, Incheol\|Yang, Jung-Hyun\|Nam, Seok Jin\|Lee, Jeong Eon
PMID:	21071999

113.
Journal:	Sci Signal. 2010 Nov 23;3(149):ra84.
Title:	BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation.
Author:	Corcoran, Ryan B\|Dias-Santagata, Dora\|Bergethon, Kristin\|Iafrate, A John\|Settleman, Jeffrey\|Engelman, Jeffrey A
PMID:	21098728

114.
Journal:	Int J Biol Markers. 2010 Oct-Dec;25(4):179-84.
Title:	Mutation analysis of BRAF exon 15 and KRAS codons 12 and 13 in Moroccan patients with colorectal cancer.
Author:	Bennani, Bahia\|Gilles, Sophie\|Fina, Frederic\|Nanni, Isabelle\|Ibrahimi, Sidi Adil\|Riffi, Afaf Amarti\|Nejjari, Chakib\|Benajeh, Dafr-Allah\|El Abkari, Mohammed\|Martin, Pierre-Marie\|Ouafik, L'Houcine
PMID:	21161938

115.
Journal:	PLoS Genet. 2010 Dec 2;6(12):e1001231.
Title:	Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells.
Author:	Jurchott, Karsten\|Kuban, Ralf-Jurgen\|Krech, Till\|Bluthgen, Nils\|Stein, Ulrike\|Walther, Wolfgang\|Friese, Christian\|Kielbasa, Szymon M\|Ungethum, Ute\|Lund, Per\|Knosel, Thomas\|Kemmner, Wolfgang\|Morkel, Markus\|Fritzmann, Johannes\|Schlag, Peter M\|Birchmeier, Wa
PMID:	21170361

116.
Journal:	Cancers (Basel). 2010 Dec 29;3(1):91-105.
Title:	Detection of up to 65% of Precancerous Lesions of the Human Colon and Rectum by Mutation Analysis of APC, K-Ras, B-Raf and CTNNB1.
Author:	Schneider, Mandy\|Scholtka, Bettina\|Gottschalk, Uwe\|Faiss, Siegbert\|Schatz, Daniela\|Berghof-Jager, Kornelia\|Steinberg, Pablo
PMID:	24212608

117.
Journal:	Inflamm Bowel Dis. 2011 May;17(5):1177-88.
Title:	DMBT1 is a novel gene induced by IL-22 in ulcerative colitis.
Author:	Fukui, Hirokazu\|Sekikawa, Akira\|Tanaka, Hiroyuki\|Fujimori, Yukari\|Katake, Yoshinori\|Fujii, Shigehiko\|Ichikawa, Kazuhito\|Tomita, Shigeki\|Imura, Johji\|Chiba, Tsutomu\|Fujimori, Takahiro
PMID:	20824812

118.
Journal:	Cancer Res. 2011 Jan 15;71(2):445-53.
Title:	MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy.
Author:	Yoon, Juyong\|Koo, Kyoung-Hwa\|Choi, Kang-Yell
PMID:	21118963

119.
Journal:	Cancer Res. 2011 Feb 1;71(3):1071-80.
Title:	Oncogenic Kras promotes chemotherapy-induced growth factor shedding via ADAM17.
Author:	Van Schaeybroeck, Sandra\|Kyula, Joan N\|Fenton, Audrey\|Fenning, Catherine S\|Sasazuki, Takehiko\|Shirasawa, Senji\|Longley, Daniel B\|Johnston, Patrick G
PMID:	21148749

120.
Journal:	Lancet Oncol. 2011 Jun;12(6):594-603.
Title:	KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer.
Author:	De Roock, Wendy\|De Vriendt, Veerle\|Normanno, Nicola\|Ciardiello, Fortunato\|Tejpar, Sabine
PMID:	21163703

121.
Journal:	Cancer Res. 2011 Jan 1;71(1):206-15.
Title:	Activation and involvement of Ral GTPases in colorectal cancer.
Author:	Martin, Timothy D\|Samuel, Jonathan C\|Routh, Elizabeth D\|Der, Channing J\|Yeh, Jen Jen
PMID:	21199803

122.
Journal:	Carcinogenesis. 2011 Jun;32(6):921-8.
Title:	Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPK.
Author:	Kang, Nam Joo\|Lee, Ki Won\|Kim, Bo Hyun\|Bode, Ann M\|Lee, Hyo-Jeong\|Heo, Yong-Seok\|Boardman, Lisa\|Limburg, Paul\|Lee, Hyong Joo\|Dong, Zigang
PMID:	21317303

123.
Journal:	Toxicol Appl Pharmacol. 2011 Aug 1;254(3):288-98.
Title:	5-Methoxyflavanone induces cell cycle arrest at the G2/M phase, apoptosis and autophagy in HCT116 human colon cancer cells.
Author:	Shin, Soon Young\|Hyun, Jiye\|Yu, Jae-Ran\|Lim, Yoongho\|Lee, Young Han
PMID:	21616090

124.
Journal:	Int J Mol Med. 2011 Oct;28(4):637-43.
Title:	Aspirin reduces the apoptotic effect of etoposide via Akt activation and up-regulation of p21(cip).
Author:	Feng, Xiaocheng\|Lu, Bin\|Xu, Yingying\|Li, Qin\|Zhou, Wenbai\|Yang, Zhihong\|Yang, Zeng\|Zhao, Weiwei\|Shen, Zonghou\|Hu, Renming
PMID:	21617849

125.
Journal:	Cancer Res. 2011 Aug 15;71(16):5535-45.
Title:	Identification of the MEK1(F129L) activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation.
Author:	Wang, Huisheng\|Daouti, Sherif\|Li, Wen-Hui\|Wen, Yang\|Rizzo, Christine\|Higgins, Brian\|Packman, Kathryn\|Rosen, Neal\|Boylan, John F\|Heimbrook, David\|Niu, Huifeng
PMID:	21705440

126.
Journal:	PLoS One. 2011;6(6):e21632.
Title:	Selective BRAFV600E inhibitor PLX4720, requires TRAIL assistance to overcome oncogenic PIK3CA resistance.
Author:	Oikonomou, Eftychia\|Koc, Michal\|Sourkova, Vladimira\|Andera, Ladislav\|Pintzas, Alexander
PMID:	21738740

127.
Journal:	PLoS One. 2011;6(7):e22769.
Title:	PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers.
Author:	Janku, Filip\|Lee, J Jack\|Tsimberidou, Apostolia M\|Hong, David S\|Naing, Aung\|Falchook, Gerald S\|Fu, Siqing\|Luthra, Rajyalakshmi\|Garrido-Laguna, Ignacio\|Kurzrock, Razelle
PMID:	21829508

128.
Journal:	Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Jul;36(7):585-91.
Title:	[Transcriptomic regulation and molecular mechanism of polygenic tumor at different stages].
Author:	Li, Xiayu\|Shen, Shourong\|Wu, Minghua\|Li, Xiaoling\|Xiong, Wei\|Lu, Jianhong\|Zhou, Ming\|Ma, Jian\|Xiang, Juanjuan\|Zeng, Zhaoyang\|Xiang, Bo\|Zhou, Yanhong\|Xiao, Lan\|Zhou, Houde\|Fan, Songqing\|Li, Guiyuan
PMID:	21873780

129.
Journal:	J Exp Clin Cancer Res. 2011 Sep 16;30:83.
Title:	Effects of metastasis-associated in colon cancer 1 inhibition by small hairpin RNA on ovarian carcinoma OVCAR-3 cells.
Author:	Zhang, Ruitao\|Shi, Huirong\|Chen, Zhimin\|Wu, Qinghua\|Ren, Fang\|Huang, Haoliang
PMID:	21923915

130.
Journal:	J Clin Invest. 2011 Nov;121(11):4311-21.
Title:	Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers.
Author:	Ebi, Hiromichi\|Corcoran, Ryan B\|Singh, Anurag\|Chen, Zhao\|Song, Youngchul\|Lifshits, Eugene\|Ryan, David P\|Meyerhardt, Jeffrey A\|Benes, Cyril\|Settleman, Jeffrey\|Wong, Kwok-Kin\|Cantley, Lewis C\|Engelman, Jeffrey A
PMID:	21985784

131.
Journal:	PLoS One. 2011;6(10):e25806.
Title:	BRAF mutations in advanced cancers: clinical characteristics and outcomes.
Author:	El-Osta, Hazem\|Falchook, Gerald\|Tsimberidou, Apostolia\|Hong, David\|Naing, Aung\|Kim, Kevin\|Wen, Sijin\|Janku, Filip\|Kurzrock, Razelle
PMID:	22039425

132.
Journal:	PLoS One. 2011;6(12):e28841.
Title:	Antitumor activity of sorafenib in human cancer cell lines with acquired resistance to EGFR and VEGFR tyrosine kinase inhibitors.
Author:	Morgillo, Floriana\|Martinelli, Erika\|Troiani, Teresa\|Orditura, Michele\|De Vita, Ferdinando\|Ciardiello, Fortunato
PMID:	22174910

133.
Journal:	J Gastrointest Cancer. 2012 Sep;43(3):444-55.
Title:	Expression of EGFR, HER2, phosphorylated ERK and phosphorylated MEK in colonic neoplasms of familial adenomatous polyposis patients.
Author:	Wang, Jayson\|Hollingshead, James\|El-Masry, Nabil\|Horncastle, Donna\|Talbot, Ian\|Tomlinson, Ian\|Alison, Malcolm R\|El-Bahrawy, Mona
PMID:	21989899

134.
Journal:	Anticancer Agents Med Chem. 2012 Feb;12(2):163-71.
Title:	Are KRAS/BRAF mutations potent prognostic and/or predictive biomarkers in colorectal cancers?
Author:	Yokota, Tomoya
PMID:	22043994

135.
Journal:	Breast Cancer Res Treat. 2012 Jun;133(3):909-16.
Title:	Expression of SPRR3 is associated with tumor cell proliferation in less advanced stages of breast cancer.
Author:	Kim, Jin Cheon\|Yu, Jong Han\|Cho, Yoon Kyung\|Jung, Choon Sik\|Ahn, Sei Hyun\|Gong, Gyungyub\|Kim, Yong Sung\|Cho, Dong-Hyung
PMID:	22076481

136.
Journal:	Clin Cancer Res. 2012 Feb 1;18(3):890-900.
Title:	Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from intergroup trial CALGB 89803.
Author:	Ogino, Shuji\|Shima, Kaori\|Meyerhardt, Jeffrey A\|McCleary, Nadine J\|Ng, Kimmie\|Hollis, Donna\|Saltz, Leonard B\|Mayer, Robert J\|Schaefer, Paul\|Whittom, Renaud\|Hantel, Alexander\|Benson, Al B 3rd\|Spiegelman, Donna\|Goldberg, Richard M\|Bertagnolli, Monica M\|Fuch
PMID:	22147942

137.
Journal:	Mol Cancer Ther. 2012 Mar;11(3):720-9.
Title:	Comprehensive predictive biomarker analysis for MEK inhibitor GSK1120212.
Author:	Jing, Junping\|Greshock, Joel\|Holbrook, Joanna Dawn\|Gilmartin, Aidan\|Zhang, Xiping\|McNeil, Elizabeth\|Conway, Theresa\|Moy, Christopher\|Laquerre, Sylvie\|Bachman, Kurt\|Wooster, Richard\|Degenhardt, Yan
PMID:	22169769

138.
Journal:	Clin Cancer Res. 2012 Feb 15;18(4):1051-62.
Title:	Preclinical activity of the rational combination of selumetinib (AZD6244) in combination with vorinostat in KRAS-mutant colorectal cancer models.
Author:	Morelli, M Pia\|Tentler, John J\|Kulikowski, Gillian N\|Tan, Aik-Choon\|Bradshaw-Pierce, Erica L\|Pitts, Todd M\|Brown, Amy M\|Nallapareddy, Sujatha\|Arcaroli, John J\|Serkova, Natalie J\|Hidalgo, Manuel\|Ciardiello, Fortunato\|Eckhardt, S Gail
PMID:	22173548

139.
Journal:	Cancer Res. 2012 Feb 1;72(3):779-89.
Title:	Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer.
Author:	Yang, Hong\|Higgins, Brian\|Kolinsky, Kenneth\|Packman, Kathryn\|Bradley, William D\|Lee, Richard J\|Schostack, Kathleen\|Simcox, Mary Ellen\|Kopetz, Scott\|Heimbrook, David\|Lestini, Brian\|Bollag, Gideon\|Su, Fei
PMID:	22180495

140.
Journal:	Hematol Oncol. 2012 Dec;30(4):190-3.
Title:	Real-time PCR-based analysis of BRAF V600E mutation in low and intermediate grade lymphomas confirms frequent occurrence in hairy cell leukaemia.
Author:	Ewalt, Mark\|Nandula, Subhadra\|Phillips, Adrienne\|Alobeid, Bachir\|Murty, Vundavalli V\|Mansukhani, Mahesh M\|Bhagat, Govind
PMID:	22246856

141.
Journal:	J Natl Cancer Inst. 2012 Feb 8;104(3):228-39.
Title:	Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome.
Author:	Ihle, Nathan T\|Byers, Lauren A\|Kim, Edward S\|Saintigny, Pierre\|Lee, J Jack\|Blumenschein, George R\|Tsao, Anne\|Liu, Suyu\|Larsen, Jill E\|Wang, Jing\|Diao, Lixia\|Coombes, Kevin R\|Chen, Lu\|Zhang, Shuxing\|Abdelmelek, Mena F\|Tang, Ximing\|Papadimitrakopoulou, Vass
PMID:	22247021

142.
Journal:	Clin Cancer Res. 2012 Apr 15;18(8):2316-25.
Title:	The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer.
Author:	Shimizu, Toshio\|Tolcher, Anthony W\|Papadopoulos, Kyriakos P\|Beeram, Muralidhar\|Rasco, Drew W\|Smith, Lon S\|Gunn, Shelly\|Smetzer, Leslie\|Mays, Theresa A\|Kaiser, Brianne\|Wick, Michael J\|Alvarez, Cathy\|Cavazos, Aracely\|Mangold, Gina L\|Patnaik, Amita
PMID:	22261800

143.
Journal:	Cancer Res. 2012 Apr 1;72(7):1804-13.
Title:	Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055).
Author:	Holt, Sarah V\|Logie, Armelle\|Davies, Barry R\|Alferez, Denis\|Runswick, Sarah\|Fenton, Sarah\|Chresta, Christine M\|Gu, Yi\|Zhang, Jingchuan\|Wu, Yi-Long\|Wilkinson, Robert W\|Guichard, Sylvie M\|Smith, Paul D
PMID:	22271687

144.
Journal:	PLoS One. 2012;7(1):e29532.
Title:	A new model for raf kinase inhibitory protein induced chemotherapeutic resistance.
Author:	Al-Mulla, Fahd\|Bitar, Milad S\|Feng, Jingwei\|Park, Sungdae\|Yeung, Kam C
PMID:	22279539

145.
Journal:	Cancer Res. 2012 Feb 1;72(3):626-35.
Title:	Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation.
Author:	Duhamel, Stephanie\|Hebert, Josee\|Gaboury, Louis\|Bouchard, Amelie\|Simon, Ronald\|Sauter, Guido\|Basik, Mark\|Meloche, Sylvain
PMID:	22298595

146.
Journal:	Oncol Rep. 2012 May;27(5):1527-34.
Title:	NF-kappaB activity is downregulated by KRAS knockdown in SW620 cells via the RAS-ERK-IkappaBalpha pathway.
Author:	Lin, Gen\|Tang, Zhiwei\|Ye, Yun-Bin\|Chen, Qiang
PMID:	22327383

147.
Journal:	PLoS One. 2012;7(2):e31729.
Title:	Induction of sodium/iodide symporter (NIS) expression and radioiodine uptake in non-thyroid cancer cells.
Author:	Liu, Zhi\|Xing, Mingzhao
PMID:	22359623

148.
Journal:	World J Surg Oncol. 2012 Feb 29;10:47.
Title:	ERK/pERK expression and B-raf mutations in colon adenocarcinomas: correlation with clinicopathological characteristics.
Author:	Levidou, Georgia\|Saetta, Angelica A\|Gigelou, Fanie\|Karlou, Maria\|Papanastasiou, Polyanthi\|Stamatelli, Angeliki\|Kavantzas, Nikolaos\|Michalopoulos, Nikolaos V\|Agrogiannis, George\|Patsouris, Efstratios\|Korkolopoulou, Penelope
PMID:	22376079

149.
Journal:	Am J Physiol Gastrointest Liver Physiol. 2012 May 15;302(10):G1223-30.
Title:	Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines.
Author:	Duerr, Eva-Maria\|Mizukami, Yusuke\|Moriichi, Kentaro\|Gala, Manish\|Jo, Won-Seok\|Kikuchi, Hirotoshi\|Xavier, Ramnik J\|Chung, Daniel C
PMID:	22383492

150.
Journal:	Clin Cancer Res. 2012 May 1;18(9):2515-25.
Title:	Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas.
Author:	Migliardi, Giorgia\|Sassi, Francesco\|Torti, Davide\|Galimi, Francesco\|Zanella, Eugenia R\|Buscarino, Michela\|Ribero, Dario\|Muratore, Andrea\|Massucco, Paolo\|Pisacane, Alberto\|Risio, Mauro\|Capussotti, Lorenzo\|Marsoni, Silvia\|Di Nicolantonio, Federica\|Bardelli,
PMID:	22392911

151.
Journal:	BMC Cancer. 2012 Mar 8;12:86.
Title:	Antitumor activities of ATP-competitive inhibitors of mTOR in colon cancer cells.
Author:	Blaser, Benjamin\|Waselle, Laurent\|Dormond-Meuwly, Anne\|Dufour, Marc\|Roulin, Didier\|Demartines, Nicolas\|Dormond, Olivier
PMID:	22401294

152.
Journal:	Chem Biol Interact. 2012 Apr 15;197(1):1-7.
Title:	Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC delta-independent mechanism.
Author:	Lim, Jun Hee\|Woo, Seon Min\|Min, Kyoung-Jin\|Park, Eun Jung\|Jang, Ji Hoon\|Seo, Bo Ram\|Iqbal, Taha\|Lee, Tae-Jin\|Kim, Sang Hyun\|Choi, Yung Hyun\|Kwon, Taeg Kyu
PMID:	22410117

153.
Journal:	Br J Cancer. 2012 Apr 10;106(8):1386-94.
Title:	The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibition.
Author:	Haagensen, E J\|Kyle, S\|Beale, G S\|Maxwell, R J\|Newell, D R
PMID:	22415236

154.
Journal:	Crit Rev Oncog. 2012;17(1):97-121.
Title:	Aberrant B-Raf signaling in human cancer -- 10 years from bench to bedside.
Author:	Roring, Michael\|Brummer, Tilman
PMID:	22471666

155.
Journal:	Clin Cancer Res. 2012 Jun 1;18(11):3132-41.
Title:	Mutations in the Ras-Raf Axis underlie the prognostic value of CD133 in colorectal cancer.
Author:	Kemper, Kristel\|Versloot, Miranda\|Cameron, Katherine\|Colak, Selcuk\|de Sousa e Melo, Felipe\|de Jong, Joan H\|Bleackley, Joanne\|Vermeulen, Louis\|Versteeg, Rogier\|Koster, Jan\|Medema, Jan Paul
PMID:	22496204

156.
Journal:	Br J Cancer. 2012 May 8;106(10):1648-59.
Title:	Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells.
Author:	Troiani, T\|Vecchione, L\|Martinelli, E\|Capasso, A\|Costantino, S\|Ciuffreda, L P\|Morgillo, F\|Vitagliano, D\|D'Aiuto, E\|De Palma, R\|Tejpar, S\|Van Cutsem, E\|De Lorenzi, M\|Caraglia, M\|Berrino, L\|Ciardiello, F
PMID:	22569000

157.
Journal:	Biochem Pharmacol. 2012 Aug 1;84(3):320-30.
Title:	MiR-139 inhibits invasion and metastasis of colorectal cancer by targeting the type I insulin-like growth factor receptor.
Author:	Shen, Ke\|Liang, Qiannan\|Xu, Ke\|Cui, Daling\|Jiang, Lin\|Yin, Peihao\|Lu, Yanhua\|Li, Qi\|Liu, Jianwen
PMID:	22580051

158.
Journal:	Small GTPases. 2012 Jan-Mar;3(1):34-9.
Title:	KRAS mutant colorectal tumors: past and present.
Author:	Brand, Toni M\|Wheeler, Deric L
PMID:	22714415

159.
Journal:	Nature. 2012 Jun 28;486(7404):532-6.
Title:	Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer.
Author:	Misale, Sandra\|Yaeger, Rona\|Hobor, Sebastijan\|Scala, Elisa\|Janakiraman, Manickam\|Liska, David\|Valtorta, Emanuele\|Schiavo, Roberta\|Buscarino, Michela\|Siravegna, Giulia\|Bencardino, Katia\|Cercek, Andrea\|Chen, Chin-Tung\|Veronese, Silvio\|Zanon, Carlo\|Sartore-B
PMID:	22722830

160.
Journal:	Mol Cancer Ther. 2012 Sep;11(9):2062-71.
Title:	Molecular profiling of patients with colorectal cancer and matched targeted therapy in phase I clinical trials.
Author:	Dienstmann, Rodrigo\|Serpico, Danila\|Rodon, Jordi\|Saura, Cristina\|Macarulla, Teresa\|Elez, Elena\|Alsina, Maria\|Capdevila, Jaume\|Perez-Garcia, Jose\|Sanchez-Olle, Gessami\|Aura, Claudia\|Prudkin, Ludmila\|Landolfi, Stefania\|Hernandez-Losa, Javier\|Vivancos, Ana\|T
PMID:	22723336

161.
Journal:	Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):E2127-33.
Title:	Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
Author:	Ohashi, Kadoaki\|Sequist, Lecia V\|Arcila, Maria E\|Moran, Teresa\|Chmielecki, Juliann\|Lin, Ya-Lun\|Pan, Yumei\|Wang, Lu\|de Stanchina, Elisa\|Shien, Kazuhiko\|Aoe, Keisuke\|Toyooka, Shinichi\|Kiura, Katsuyuki\|Fernandez-Cuesta, Lynnette\|Fidias, Panos\|Yang, James Chi
PMID:	22773810

162.
Journal:	Cancer Biol Ther. 2012 Nov;13(13):1235-43.
Title:	K-Ras gene mutation status as a prognostic and predictive factor in patients with colorectal cancer undergoing irinotecan- or oxaliplatin-based chemotherapy.
Author:	Stec, Rafal\|Bodnar, Lubomir\|Charkiewicz, Radoslaw\|Korniluk, Jan\|Rokita, Marta\|Smoter, Marta\|Ciechowicz, Marzena\|Chyczewski, Lech\|Niklinski, Jacek\|Kozlowski, Wojciech\|Szczylik, Cezary
PMID:	22909976

163.
Journal:	Int J Oncol. 2012 Nov;41(5):1855-62.
Title:	Combination therapy targeting Raf-1 and MEK causes apoptosis of HCT116 colon cancer cells.
Author:	Subramanian, Romesh R\|Yamakawa, Akio
PMID:	22922669

164.
Journal:	PLoS One. 2012;7(10):e48461.
Title:	Src-mediated cross-talk between farnesoid X and epidermal growth factor receptors inhibits human intestinal cell proliferation and tumorigenesis.
Author:	Peng, Zhongsheng\|Raufman, Jean-Pierre\|Xie, Guofeng
PMID:	23119029

165.
Journal:	Cell. 2012 Nov 21;151(5):937-50.
Title:	MED12 controls the response to multiple cancer drugs through regulation of TGF-beta receptor signaling.
Author:	Huang, Sidong\|Holzel, Michael\|Knijnenburg, Theo\|Schlicker, Andreas\|Roepman, Paul\|McDermott, Ultan\|Garnett, Mathew\|Grernrum, Wipawadee\|Sun, Chong\|Prahallad, Anirudh\|Groenendijk, Floris H\|Mittempergher, Lorenza\|Nijkamp, Wouter\|Neefjes, Jacques\|Salazar, Ramo
PMID:	23178117

166.
Journal:	BMC Cancer. 2012 Dec 21;12:612.
Title:	Alternative dosing of dual PI3K and MEK inhibition in cancer therapy.
Author:	Jokinen, Elina\|Laurila, Niina\|Koivunen, Jussi P
PMID:	23259591

167.
Journal:	Asian Pac J Cancer Prev. 2012;13(11):5599-603.
Title:	Mutational analysis of key EGFR pathway genes in Chinese breast cancer patients.
Author:	Tong, Lin\|Yang, Xue-Xi\|Liu, Min-Feng\|Yao, Guang-Yu\|Dong, Jian-Yu\|Ye, Chang-Sheng\|Li, Ming
PMID:	23317280

168.
Journal:	World J Nucl Med. 2012 May;11(2):65-9.
Title:	(18)F-FLT-PET for Response Evaluation of MEK Inhibitor Selumetinib (AZD6244, ARRY-142886) in Patients with Solid Tumors.
Author:	Desar, Ingrid M E\|Gilles, Rozemarie\|van Herpen, Carla M L\|Timmer-Bonte, Anja J N H\|Cantarini, Mireille V\|van der Graaf, Winette T A\|Oyen, Wim J G
PMID:	23372439

169.
Journal:	Yao Xue Xue Bao. 2012 Dec;47(12):1567-74.
Title:	[Progress of anti-tumor study based on BRAF].
Author:	Yan, Gui-Rui\|Xu, Zhi-Jian\|Wang, He-Yao\|Zhu, Wei-Liang
PMID:	23460959

170.
Journal:	Environ Toxicol. 2013 Sep;28(9):479-88.
Title:	Diallyl sulfide, diallyl disulfide, and diallyl trisulfide inhibit migration and invasion in human colon cancer colo 205 cells through the inhibition of matrix metalloproteinase-2, -7, and -9 expressions.
Author:	Lai, Kuang-Chi\|Hsu, Shu-Chun\|Kuo, Chao-Lin\|Yang, Jai-Sing\|Ma, Chia-Yu\|Lu, Hsu-Feng\|Tang, Nou-Ying\|Hsia, Te-Chun\|Ho, Heng-Chien\|Chung, Jing-Gung
PMID:	21695758

171.
Journal:	Oncogene. 2013 Jan 31;32(5):564-76.
Title:	Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition.
Author:	Cagnol, S\|Rivard, N
PMID:	22430215

172.
Journal:	Int J Cancer. 2013 Feb 1;132(3):E149-57.
Title:	Mitogen-activated protein kinase (MEK/ERK) inhibition sensitizes cancer cells to centromere-associated protein E inhibition.
Author:	Mayes, Patrick A\|Degenhardt, Yan Y\|Wood, Andrew\|Toporovskya, Yana\|Diskin, Sharon J\|Haglund, Elizabeth\|Moy, Christopher\|Wooster, Richard\|Maris, John M
PMID:	22948716

173.
Journal:	Am J Pathol. 2013 Feb;182(2):565-76.
Title:	CD133 affects the invasive ability of HCT116 cells by regulating TIMP-2.
Author:	Zhang, Min\|Liu, Yanyan\|Feng, Hailiang\|Bian, Xiaocui\|Zhao, Wenjing\|Yang, Zhenli\|Gu, Bei\|Li, Zhanwen\|Liu, Yuqin
PMID:	23195431

174.
Journal:	Mol Cancer Res. 2013 Feb;11(2):109-21.
Title:	Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling.
Author:	Tabusa, Hana\|Brooks, Teresa\|Massey, Andrew J
PMID:	23233484

175.
Journal:	Crit Rev Oncol Hematol. 2013 Jul;87(1):55-68.
Title:	BRAF mutations in melanoma and colorectal cancer: a single oncogenic mutation with different tumour phenotypes and clinical implications.
Author:	Sclafani, F\|Gullo, G\|Sheahan, K\|Crown, J
PMID:	23246082

176.
Journal:	Front Biosci (Elite Ed). 2013 Jan 1;5:574-82.
Title:	Effect of genomic instability and mutations on the signaling pathways in colon cancer cells.
Author:	Cui, Miao\|Ye, Fei\|Jiang, Bo\|Deng, Peng\|Wang, Xinying\|Jiang, Yong\|Zhang, David Yong
PMID:	23277013

177.
Journal:	Hepatology. 2013 Jun;57(6):2299-313.
Title:	MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer.
Author:	Peng, Hui\|Dara, Lily\|Li, Tony W H\|Zheng, Yuhua\|Yang, Heping\|Tomasi, Maria Lauda\|Tomasi, Ivan\|Giordano, Pasquale\|Mato, Jose M\|Lu, Shelly C
PMID:	23325601

178.
Journal:	Biochim Biophys Acta. 2013 Jul;1834(7):1396-401.
Title:	Quantitative NMR analysis of Erk activity and inhibition by U0126 in a panel of patient-derived colorectal cancer cell lines.
Author:	Rose, Honor May\|Stuiver, Marchel\|Thongwichian, Rossukon\|Theillet, Francois-Xavier\|Feller, Stephan M\|Selenko, Philipp
PMID:	23360766

179.
Journal:	Cancer Sci. 2013 May;104(5):604-10.
Title:	Norcantharidin inhibits tumor angiogenesis via blocking VEGFR2/MEK/ERK signaling pathways.
Author:	Zhang, Long\|Ji, Qing\|Liu, Xuan\|Chen, Xingzhu\|Chen, Zhaohua\|Qiu, Yanyan\|Sun, Jian\|Cai, Jianfeng\|Zhu, Huirong\|Li, Qi
PMID:	23363445

180.
Journal:	Cancer Discov. 2013 May;3(5):520-33.
Title:	Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas.
Author:	Montero-Conde, Cristina\|Ruiz-Llorente, Sergio\|Dominguez, Jose M\|Knauf, Jeffrey A\|Viale, Agnes\|Sherman, Eric J\|Ryder, Mabel\|Ghossein, Ronald A\|Rosen, Neal\|Fagin, James A
PMID:	23365119

181.
Journal:	Cancer Sci. 2013 Jun;104(6):687-93.
Title:	Novel MEK inhibitor trametinib and other retinoblastoma gene (RB)-reactivating agents enhance efficacy of 5-fluorouracil on human colon cancer cells.
Author:	Watanabe, Motoki\|Sowa, Yoshihiro\|Yogosawa, Mayumi\|Sakai, Toshiyuki
PMID:	23438367

182.
Journal:	Br J Pharmacol. 2013 Aug;169(8):1766-80.
Title:	YL529, a novel, orally available multikinase inhibitor, potently inhibits angiogenesis and tumour growth in preclinical models.
Author:	Xu, Youzhi\|Lin, Hongjun\|Meng, Nana\|Lu, Wenjie\|Li, Guobo\|Han, Yuanyuan\|Dai, Xiaoyun\|Xia, Yong\|Song, Xiangrong\|Yang, Shengyong\|Wei, Yuquan\|Yu, Luoting\|Zhao, Yinglan
PMID:	23594209

183.
Journal:	Toxicol In Vitro. 2013 Sep;27(6):1626-33.
Title:	Activation of ERK signaling and induction of colon cancer cell death by piperlongumine.
Author:	Randhawa, H\|Kibble, K\|Zeng, H\|Moyer, M P\|Reindl, K M
PMID:	23603476

184.
Journal:	Int J Cancer. 2013 Nov;133(9):2089-101.
Title:	Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells.
Author:	Martinelli, Erika\|Troiani, Teresa\|D'Aiuto, Elena\|Morgillo, Floriana\|Vitagliano, Donata\|Capasso, Anna\|Costantino, Sarah\|Ciuffreda, Loreta Pia\|Merolla, Francesco\|Vecchione, Loredana\|De Vriendt, Veerle\|Tejpar, Sabine\|Nappi, Anna\|Sforza, Vincenzo\|Martini, Giu
PMID:	23629727

185.
Journal:	Exp Cell Res. 2013 Aug 1;319(13):2081-90.
Title:	S100P/RAGE signaling regulates microRNA-155 expression via AP-1 activation in colon cancer.
Author:	Onyeagucha, Benjamin Chidi\|Mercado-Pimentel, Melania E\|Hutchison, Jennifer\|Flemington, Erik K\|Nelson, Mark A
PMID:	23693020

186.
Journal:	Anticancer Res. 2013 Jun;33(6):2499-508.
Title:	Combination of CYP inhibitor with MEK/ERK inhibitor enhances the inhibitory effect on ERK in BRAF mutant colon cancer cells.
Author:	Lim, Sun Min\|Hwang, Jee Won\|Ahn, Joong Bae\|Bae, Soo Kyung\|Park, Chan Hee\|Kim, Ki-Yeol\|Rha, Sun Young\|Chung, Hyun Cheol\|Roh, Jae Kyung\|Shin, Sang Joon
PMID:	23749901

187.
Journal:	Clin Cancer Res. 2013 Aug 1;19(15):4149-62.
Title:	Rational combination of a MEK inhibitor, selumetinib, and the Wnt/calcium pathway modulator, cyclosporin A, in preclinical models of colorectal cancer.
Author:	Spreafico, Anna\|Tentler, John J\|Pitts, Todd M\|Tan, Aik Choon\|Gregory, Mark A\|Arcaroli, John J\|Klauck, Peter J\|McManus, Martine C\|Hansen, Ryan J\|Kim, Jihye\|Micel, Lindsey N\|Selby, Heather M\|Newton, Timothy P\|McPhillips, Kelly L\|Gustafson, Daniel L\|Degregor
PMID:	23757356

188.
Journal:	BMC Cancer. 2013 Jul 1;13:321.
Title:	Overexpression of peptide deformylase in breast, colon, and lung cancers.
Author:	Randhawa, Harsharan\|Chikara, Shireen\|Gehring, Drew\|Yildirim, Tuba\|Menon, Jyotsana\|Reindl, Katie M
PMID:	23815882

189.
Journal:	PLoS One. 2013 Jul 3;8(7):e67583.
Title:	Dabrafenib; preclinical characterization, increased efficacy when combined with trametinib, while BRAF/MEK tool combination reduced skin lesions.
Author:	King, Alastair J\|Arnone, Marc R\|Bleam, Maureen R\|Moss, Katherine G\|Yang, Jingsong\|Fedorowicz, Kelly E\|Smitheman, Kimberly N\|Erhardt, Joseph A\|Hughes-Earle, Angela\|Kane-Carson, Laurie S\|Sinnamon, Robert H\|Qi, Hongwei\|Rheault, Tara R\|Uehling, David E\|Laquer
PMID:	23844038

190.
Journal:	Anticancer Agents Med Chem. 2013 Dec;13(10):1540-50.
Title:	Garcinia benzophenones inhibit the growth of human colon cancer cells and synergize with sulindac sulfide and turmeric.
Author:	Einbond, Linda Saxe\|Mighty, Jason\|Kashiwazaki, Ryota\|Figueroa, Mario\|Jalees, Filza\|Acuna, Ulyana Munoz\|Le Gendre, Onica\|Foster, David A\|Kennelly, Edward J
PMID:	23848206

191.
Journal:	Fitoterapia. 2013 Dec;91:28-38.
Title:	Actein induces calcium release in human breast cancer cells.
Author:	Einbond, Linda Saxe\|Mighty, Jason\|Redenti, Stephen\|Wu, Hsan-Au
PMID:	23939423

192.
Journal:	Eur J Cancer. 2013 Dec;49(18):3924-35.
Title:	miR-133a represses tumour growth and metastasis in colorectal cancer by targeting LIM and SH3 protein 1 and inhibiting the MAPK pathway.
Author:	Wang, Hui\|An, Hongying\|Wang, Bin\|Liao, Qing\|Li, Weidong\|Jin, Xuejun\|Cui, Shuzhong\|Zhang, Yajie\|Ding, Yanqing\|Zhao, Liang
PMID:	23968734

193.
Journal:	Am J Pathol. 2013 Nov;183(5):1667-78.
Title:	Src plays a key role in ADAM28 expression in v-src-transformed epithelial cells and human carcinoma cells.
Author:	Abe, Hitoshi\|Mochizuki, Satsuki\|Ohara, Kentaro\|Ueno, Mari\|Ochiai, Hiroki\|Kitagawa, Yuko\|Hino, Okio\|Sato, Hiroshi\|Okada, Yasunori
PMID:	24007880

194.
Journal:	Cell Death Dis. 2013 Sep 12;4:e801.
Title:	Metastatic SW620 colon cancer cells are primed for death when detached and can be sensitized to anoikis by the BH3-mimetic ABT-737.
Author:	Maamer-Azzabi, A\|Ndozangue-Touriguine, O\|Breard, J
PMID:	24030153

195.
Journal:	Clin Cancer Res. 2013 Nov 15;19(22):6219-29.
Title:	Overcoming IGF1R/IR resistance through inhibition of MEK signaling in colorectal cancer models.
Author:	Flanigan, Sara A\|Pitts, Todd M\|Newton, Timothy P\|Kulikowski, Gillian N\|Tan, Aik Choon\|McManus, Martine C\|Spreafico, Anna\|Kachaeva, Maria I\|Selby, Heather M\|Tentler, John J\|Eckhardt, S Gail\|Leong, Stephen
PMID:	24045180

196.
Journal:	Ann Pharmacother. 2013 Dec;47(12):1685-96.
Title:	Regorafenib: a novel multitargeted tyrosine kinase inhibitor for colorectal cancer and gastrointestinal stromal tumors.
Author:	Crona, Daniel J\|Keisler, Meredith D\|Walko, Christine M
PMID:	24259629

197.
Journal:	Front Oncol. 2013 Nov 15;3:281.
Title:	Toward a Molecular Classification of Colorectal Cancer: The Role of BRAF.
Author:	Thiel, Alexandra\|Ristimaki, Ari
PMID:	24298448

198.
Journal:	Int J Med Sci. 2013 Nov 25;10(13):1888-98.
Title:	Modulation of beta-catenin signaling by the inhibitors of MAP kinase, tyrosine kinase, and PI3-kinase pathways.
Author:	Zhang, Wenwen\|Zhang, Hongyu\|Wang, Ning\|Zhao, Chen\|Zhang, Hongmei\|Deng, Fang\|Wu, Ningning\|He, Yunfeng\|Chen, Xian\|Zhang, Junhui\|Wen, Sheng\|Liao, Zhan\|Zhang, Qian\|Zhang, Zhonglin\|Liu, Wei\|Yan, Zhengjian\|Luu, Hue H\|Haydon, Rex C\|Zhou, Lan\|He, Tong-Chuan
PMID:	24324366

199.
Journal:	BMC Cancer. 2013 Dec 13;13:599.
Title:	The prognostic values of EGFR expression and KRAS mutation in patients with synchronous or metachronous metastatic colorectal cancer.
Author:	Huang, Ching-Wen\|Tsai, Hsiang-Lin\|Chen, Yi-Ting\|Huang, Chun-Ming\|Ma, Cheng-Jen\|Lu, Chien-Yu\|Kuo, Chao-Hung\|Wu, Deng-Chyang\|Chai, Chee-Yin\|Wang, Jaw-Yuan
PMID:	24330663

200.
Journal:	PLoS One. 2013 Dec 10;8(12):e81763.
Title:	The enhanced in vivo activity of the combination of a MEK and a PI3K inhibitor correlates with [18F]-FLT PET in human colorectal cancer xenograft tumour-bearing mice.
Author:	Haagensen, Emma J\|Thomas, Huw D\|Wilson, Ian\|Harnor, Suzannah J\|Payne, Sara L\|Rennison, Tommy\|Smith, Kate M\|Maxwell, Ross J\|Newell, David R
PMID:	24339963

201.
Journal:	Mol Carcinog. 2014 Feb;53 Suppl 1:E62-71.
Title:	The molecular chaperone Cosmc enhances malignant behaviors of colon cancer cells via activation of Akt and ERK.
Author:	Huang, John\|Che, Mei-Ieng\|Lin, Neng-Yu\|Hung, Ji-Shiang\|Huang, Yu-Ting\|Lin, Wei-Chou\|Huang, Hsiu-Chin\|Lee, Po-Huang\|Liang, Jin-Tung\|Huang, Min-Chuan
PMID:	23390052

202.
Journal:	Oncogene. 2014 Apr 3;33(14):1828-39.
Title:	ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer.
Author:	Ye, Q\|Cai, W\|Zheng, Y\|Evers, B M\|She, Q-B
PMID:	23624914

203.
Journal:	Mol Med Rep. 2014 Jan;9(1):243-8.
Title:	Caffeine inhibits paclitaxelinduced apoptosis in colorectal cancer cells through the upregulation of Mcl1 levels.
Author:	Mhaidat, Nizar M\|Alzoubi, Karem H\|Al-Azzam, Sayer I\|Alsaad, Alhareth A
PMID:	24173825

204.
Journal:	Mol Cancer Res. 2014 Feb;12(2):228-38.
Title:	The metalloprotease ADAMTS8 displays antitumor properties through antagonizing EGFR-MEK-ERK signaling and is silenced in carcinomas by CpG methylation.
Author:	Choi, Gigi C G\|Li, Jisheng\|Wang, Yajun\|Li, Lili\|Zhong, Lan\|Ma, Brigette\|Su, Xianwei\|Ying, Jianming\|Xiang, Tingxiu\|Rha, Sun Young\|Yu, Jun\|Sung, Joseph J Y\|Tsao, Sai Wah\|Chan, Anthony T C\|Tao, Qian
PMID:	24184540

205.
Journal:	Pharmacol Res. 2014 Jan;79:34-74.
Title:	The ErbB/HER family of protein-tyrosine kinases and cancer.
Author:	Roskoski, Robert Jr
PMID:	24269963

206.
Journal:	Pharmacol Ther. 2014 May;142(2):176-82.
Title:	BRAF inhibitors in cancer therapy.
Author:	Hertzman Johansson, Carolina\|Egyhazi Brage, Suzanne
PMID:	24325952

207.
Journal:	Int J Clin Oncol. 2014 Apr;19(2):211-9.
Title:	Is biomarker research advancing in the era of personalized medicine for head and neck cancer?
Author:	Yokota, Tomoya
PMID:	24442754

208.
Journal:	Digestion. 2014;89(1):18-23.
Title:	Biomarkers for predicting the efficacy of anti-epidermal growth factor receptor antibody in the treatment of colorectal cancer.
Author:	Okada, Yasuyuki\|Miyamoto, Hiroshi\|Goji, Takahiro\|Takayama, Tetsuji
PMID:	24458108

209.
Journal:	Anticancer Agents Med Chem. 2014;14(7):1051-61.
Title:	ent-kaurane diterpenoids from Croton tonkinensis induce apoptosis in colorectal cancer cells through the phosphorylation of JNK mediated by reactive oxygen species and dual-specificity JNK kinase MKK4.
Author:	Thuong, Phuong Thien\|Khoi, Nguyen Minh\|Ohta, Saho\|Shiota, Shinichiro\|Kanta, Hironori\|Takeuchi, Kenji\|Ito, Fumiaki
PMID:	24476312

210.
Journal:	Cancer Sci. 2014 Apr;105(4):425-30.
Title:	MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells.
Author:	Sakai, Hiroaki\|Sato, Ai\|Aihara, Yuki\|Ikarashi, Yoshinori\|Midorikawa, Yutaka\|Kracht, Michael\|Nakagama, Hitoshi\|Okamoto, Koji
PMID:	24533778

211.
Journal:	Sci Transl Med. 2014 Feb 19;6(224):224ra26.
Title:	Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer.
Author:	Misale, Sandra\|Arena, Sabrina\|Lamba, Simona\|Siravegna, Giulia\|Lallo, Alice\|Hobor, Sebastijan\|Russo, Mariangela\|Buscarino, Michela\|Lazzari, Luca\|Sartore-Bianchi, Andrea\|Bencardino, Katia\|Amatu, Alessio\|Lauricella, Calogero\|Valtorta, Emanuele\|Siena, Salvato
PMID:	24553387

212.
Journal:	Nat Cell Biol. 2014 Mar;16(3):268-80.
Title:	MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells.
Author:	Hwang, Wei-Lun\|Jiang, Jeng-Kae\|Yang, Shung-Haur\|Huang, Tse-Shun\|Lan, Hsin-Yi\|Teng, Hao-Wei\|Yang, Chih-Yung\|Tsai, Ya-Ping\|Lin, Chi-Hung\|Wang, Hsei-Wei\|Yang, Muh-Hwa
PMID:	24561623

213.
Journal:	J Cell Biochem. 2014 Mar;115(3):464-75.
Title:	Desacetyluvaricin induces S phase arrest in SW480 colorectal cancer cells through superoxide overproduction.
Author:	Xue, Jun-Yi\|Zhou, Guang-Xiong\|Chen, Tianfeng\|Gao, Si\|Choi, Mei-Yuk\|Wong, Yum-Shing
PMID:	24591255

214.
Journal:	J Clin Endocrinol Metab. 2014 Jul;99(7):E1163-72.
Title:	ZIC1 is a putative tumor suppressor in thyroid cancer by modulating major signaling pathways and transcription factor FOXO3a.
Author:	Qiang, Wei\|Zhao, Yuan\|Yang, Qi\|Liu, Wei\|Guan, Haixia\|Lv, Siqing\|Ji, Meiju\|Shi, Bingyin\|Hou, Peng
PMID:	24684457

215.
Journal:	Cell Rep. 2014 Apr 10;7(1):86-93.
Title:	Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3.
Author:	Sun, Chong\|Hobor, Sebastijan\|Bertotti, Andrea\|Zecchin, Davide\|Huang, Sidong\|Galimi, Francesco\|Cottino, Francesca\|Prahallad, Anirudh\|Grernrum, Wipawadee\|Tzani, Anna\|Schlicker, Andreas\|Wessels, Lodewyk F A\|Smit, Egbert F\|Thunnissen, Erik\|Halonen, Pasi\|Lieft
PMID:	24685132

216.
Journal:	Ann Surg Oncol. 2014 Aug;21(8):2642-9.
Title:	The frequencies and clinical implications of mutations in 33 kinase-related genes in locally advanced rectal cancer: a pilot study.
Author:	Abdul-Jalil, Khairun I\|Sheehan, Katherine M\|Toomey, Sinead\|Schmid, Jasmin\|Prehn, Jochen\|O'Grady, Anthony\|Cummins, Robert\|O'Neill, Brian\|McNamara, Deborah A\|Deasy, Joseph\|Breathnach, Oscar\|Grogan, Liam\|Rogers, Ailin\|Doherty, Glen\|Winter, Des\|Ryan, John\|El-
PMID:	24700299

217.
Journal:	Recent Results Cancer Res. 2014;201:215-25.
Title:	Vemurafenib.
Author:	Garbe, Claus\|Abusaif, Sail\|Eigentler, Thomas K
PMID:	24756795

218.
Journal:	Recent Results Cancer Res. 2014;201:241-8.
Title:	Trametinib.
Author:	Zeiser, Robert
PMID:	24756797

219.
Journal:	Clin Cancer Res. 2014 Jul 15;20(14):3775-86.
Title:	Primary and acquired resistance of colorectal cancer cells to anti-EGFR antibodies converge on MEK/ERK pathway activation and can be overcome by combined MEK/EGFR inhibition.
Author:	Troiani, Teresa\|Napolitano, Stefania\|Vitagliano, Donata\|Morgillo, Floriana\|Capasso, Anna\|Sforza, Vincenzo\|Nappi, Anna\|Ciardiello, Davide\|Ciardiello, Fortunato\|Martinelli, Erika
PMID:	24812410

220.
Journal:	Mol Oncol. 2014 Sep 12;8(6):1084-94.
Title:	Acquired resistance to EGFR-targeted therapies in colorectal cancer.
Author:	Van Emburgh, Beth O\|Sartore-Bianchi, Andrea\|Di Nicolantonio, Federica\|Siena, Salvatore\|Bardelli, Alberto
PMID:	24913799

221.
Journal:	Cell Rep. 2014 Jun 26;7(6):1940-55.
Title:	ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal cancer.
Author:	Van Schaeybroeck, Sandra\|Kalimutho, Murugan\|Dunne, Philip D\|Carson, Robbie\|Allen, Wendy\|Jithesh, Puthen V\|Redmond, Keara L\|Sasazuki, Takehiko\|Shirasawa, Senji\|Blayney, Jaine\|Michieli, Paolo\|Fenning, Cathy\|Lenz, Heinz-Josef\|Lawler, Mark\|Longley, Daniel B\|J
PMID:	24931611

222.
Journal:	Clin Cancer Res. 2014 Aug 15;20(16):4251-61.
Title:	Phase I expansion and pharmacodynamic study of the oral MEK inhibitor RO4987655 (CH4987655) in selected patients with advanced cancer with RAS-RAF mutations.
Author:	Zimmer, Lisa\|Barlesi, Fabrice\|Martinez-Garcia, Maria\|Dieras, Veronique\|Schellens, Jan H M\|Spano, Jean-Philippe\|Middleton, Mark R\|Calvo, Emiliano\|Paz-Ares, Luiz\|Larkin, James\|Pacey, Simon\|Venturi, Miro\|Kraeber-Bodere, Francoise\|Tessier, Jean J L\|Eberhardt,
PMID:	24947927

223.
Journal:	Int J Oncol. 2014 Sep;45(3):1036-42.
Title:	Phloroglucinol induces apoptosis through the regulation of insulin-like growth factor 1 receptor signaling pathways in human colon cancer HT-29 cells.
Author:	Kang, Mi-Hye\|Kim, In-Hye\|Nam, Taek-Jeong
PMID:	24970012

224.
Journal:	PLoS One. 2014 Jul 8;9(7):e101889.
Title:	The study of a novel sorafenib derivative HLC-080 as an antitumor agent.
Author:	Tang, Ke\|Luo, Can\|Li, Yan\|Lu, Chenshu\|Zhou, Wanqi\|Huang, Haihong\|Chen, Xiaoguang
PMID:	25004130

225.
Journal:	Oncol Lett. 2014 Aug;8(2):869-875.
Title:	BRAF-activated long non-coding RNA contributes to colorectal cancer migration by inducing epithelial-mesenchymal transition.
Author:	Guo, Qinhao\|Zhao, Yan\|Chen, Jiejing\|Hu, Jun\|Wang, Shuwei\|Zhang, Dongsheng\|Sun, Yueming
PMID:	25013510

226.
Journal:	Mol Cancer. 2014 Aug 29;13:201.
Title:	Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer.
Author:	El-Baba, Chirine\|Mahadevan, Vijayalakshmi\|Fahlbusch, Fabian B\|Mohan S, Suma\|Rau, Tilman T\|Gali-Muhtasib, Hala\|Schneider-Stock, Regine
PMID:	25174975

227.
Journal:	Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13505-10.
Title:	Phospholipase Cdelta1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells.
Author:	Satow, Reiko\|Hirano, Tamaki\|Batori, Ryosuke\|Nakamura, Tomomi\|Murayama, Yumi\|Fukami, Kiyoko
PMID:	25197077

228.
Journal:	Biomed Res Int. 2014;2014:568693.
Title:	Biological and molecular effects of small molecule kinase inhibitors on low-passage human colorectal cancer cell lines.
Author:	Lange, Falko\|Franz, Benjamin\|Maletzki, Claudia\|Linnebacher, Michael\|Huhns, Maja\|Jaster, Robert
PMID:	25309914

229.
Journal:	PLoS One. 2014 Nov 17;9(11):e113037.
Title:	Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer.
Author:	Pitts, Todd M\|Newton, Timothy P\|Bradshaw-Pierce, Erica L\|Addison, Rebecca\|Arcaroli, John J\|Klauck, Peter J\|Bagby, Stacey M\|Hyatt, Stephanie L\|Purkey, Alicia\|Tentler, John J\|Tan, Aik Choon\|Messersmith, Wells A\|Eckhardt, S Gail\|Leong, Stephen
PMID:	25401499

230.
Journal:	PLoS One. 2014 Dec 26;9(12):e115443.
Title:	Inhibition of TMEM16A expression suppresses growth and invasion in human colorectal cancer cells.
Author:	Sui, Yujie\|Sun, Meiyan\|Wu, Fei\|Yang, Longfei\|Di, Weihua\|Zhang, Guizhen\|Zhong, Lili\|Ma, Zhiming\|Zheng, Jinhao\|Fang, Xuedong\|Ma, Tonghui
PMID:	25541940

231.
Journal:	Oncogene. 2015 Jan 22;34(4):531-6.
Title:	A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity.
Author:	Bajpe, P K\|Prahallad, A\|Horlings, H\|Nagtegaal, I\|Beijersbergen, R\|Bernards, R
PMID:	24469059

232.
Journal:	Environ Toxicol. 2015 Jul;30(7):852-63.
Title:	Crude extract of Rheum palmatum L inhibits migration and invasion of LS1034 human colon cancer cells acts through the inhibition of matrix metalloproteinase-2/-9 by MAPK signaling.
Author:	Ma, Yi-Shih\|Hsiao, Yu-Ping\|Lin, Ju-Hwa\|Hsu, Shu-Chun\|Chueh, Fu-Shin\|Weng, Shu-Wen\|Lai, Kuang-Chi\|Lin, Jaung-Geng\|Chung, Jing-Gung
PMID:	24497447

233.
Journal:	Mol Oncol. 2015 Feb;9(2):377-88.
Title:	TNF-alpha promotes invasive growth through the MET signaling pathway.
Author:	Bigatto, Viola\|De Bacco, Francesca\|Casanova, Elena\|Reato, Gigliola\|Lanzetti, Letizia\|Isella, Claudio\|Sarotto, Ivana\|Comoglio, Paolo M\|Boccaccio, Carla
PMID:	25306394

234.
Journal:	Cancer Chemother Pharmacol. 2015 Jan;75(1):17-23.
Title:	Phase II study of selumetinib (AZD6244, ARRY-142886) plus irinotecan as second-line therapy in patients with K-RAS mutated colorectal cancer.
Author:	Hochster, H S\|Uboha, N\|Messersmith, W\|Gold, P J\|ONeil, B H\|Cohen, D\|Denlinger, C\|Cohen, S\|Leichman, C G\|Leichman, L\|Lenz, H-J
PMID:	25322874

235.
Journal:	Proteomics. 2015 Jan;15(1):77-88.
Title:	Impact of the mitogen-activated protein kinase pathway on the subproteome of detergent-resistant microdomains of colon carcinoma cells.
Author:	Recktenwald, Christian V\|Lichtenfels, Rudolf\|Wulfaenger, Jens\|Muller, Anja\|Dressler, Sven P\|Seliger, Barbara
PMID:	25359454

236.
Journal:	Cancer Res. 2015 Jan 1;75(1):216-29.
Title:	B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells.
Author:	Herr, Ricarda\|Kohler, Martin\|Andrlova, Hana\|Weinberg, Florian\|Moller, Yvonne\|Halbach, Sebastian\|Lutz, Lisa\|Mastroianni, Justin\|Klose, Martin\|Bittermann, Nicola\|Kowar, Silke\|Zeiser, Robert\|Olayioye, Monilola A\|Lassmann, Silke\|Busch, Hauke\|Boerries, Melanie
PMID:	25381152

237.
Journal:	Int J Cancer. 2015 Jul 1;137(1):243-50.
Title:	PKC/MEK inhibitors suppress oxaliplatin-induced neuropathy and potentiate the antitumor effects.
Author:	Tsubaki, Masanobu\|Takeda, Tomoya\|Tani, Tadahumi\|Shimaoka, Hirotaka\|Suzuyama, Naohiro\|Sakamoto, Kotaro\|Fujita, Arisa\|Ogawa, Naoki\|Itoh, Tatsuki\|Imano, Motohiro\|Funakami, Yoshinori\|Ichida, Seiji\|Satou, Takao\|Nishida, Shozo
PMID:	25430564

238.
Journal:	Biochim Biophys Acta. 2015 Apr;1850(4):640-6.
Title:	Spontaneously hyperactive MEK-Erk pathway mediates paradoxical facilitation of cell proliferation in mild hypoxia.
Author:	Miyamoto, Licht\|Yagi, Yuko\|Hatano, Aya\|Kawazoe, Kazuyoshi\|Ishizawa, Keisuke\|Minakuchi, Kazuo\|Tomita, Shuhei\|Tsuchiya, Koichiro
PMID:	25497211

239.
Journal:	Oncogene. 2015 Sep 17;34(38):4914-27.
Title:	Oncogenic KRAS signalling promotes the Wnt/beta-catenin pathway through LRP6 in colorectal cancer.
Author:	Lemieux, E\|Cagnol, S\|Beaudry, K\|Carrier, J\|Rivard, N
PMID:	25500543

240.
Journal:	Anticancer Drugs. 2015 Apr;26(4):371-8.
Title:	Effect of KRAS exon 2 mutations on antitumor activity of afatinib and gefitinib.
Author:	Gamba, Sebastian\|Camaj, Peter\|Heinemann, Volker\|Laubender, Rudiger P\|Wang, Yan\|Zhao, Yue\|Stintzing, Sebastian\|Giessen, Clemens\|Boeck, Stefan\|Haertl, Christoph\|Bruns, Christiane J\|Modest, Dominik P
PMID:	25514114

241.
Journal:	Inflamm Bowel Dis. 2015 Feb;21(2):287-96.
Title:	Overexpression of PAK1 promotes cell survival in inflammatory bowel diseases and colitis-associated cancer.
Author:	Khare, Vineeta\|Dammann, Kyle\|Asboth, Mario\|Krnjic, Anita\|Jambrich, Manuela\|Gasche, Christoph
PMID:	25569743

242.
Journal:	Invest New Drugs. 2015 Jun;33(3):720-8.
Title:	Biomarker-driven phase 2 study of MK-2206 and selumetinib (AZD6244, ARRY-142886) in patients with colorectal cancer.
Author:	Do, Khanh\|Speranza, Giovanna\|Bishop, Rachel\|Khin, Sonny\|Rubinstein, Larry\|Kinders, Robert J\|Datiles, Manuel\|Eugeni, Michelle\|Lam, Michael H\|Doyle, L Austin\|Doroshow, James H\|Kummar, Shivaani
PMID:	25637165

243.
Journal:	Cell Signal. 2015 Apr;27(4):860-6.
Title:	HGF-activated colonic fibroblasts mediates carcinogenesis of colonic epithelial cancer cells via PKC-cMET-ERK1/2-COX-2 signaling.
Author:	Li, F\|Zhu, Y-T
PMID:	25643632

244.
Journal:	Oncogene. 2015 Oct 1;34(40):5187-97.
Title:	MUC1-C activates the TAK1 inflammatory pathway in colon cancer.
Author:	Takahashi, H\|Jin, C\|Rajabi, H\|Pitroda, S\|Alam, M\|Ahmad, R\|Raina, D\|Hasegawa, M\|Suzuki, Y\|Tagde, A\|Bronson, R T\|Weichselbaum, R\|Kufe, D
PMID:	25659581

245.
Journal:	Cancer Discov. 2015 Apr;5(4):358-67.
Title:	Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations.
Author:	Ahronian, Leanne G\|Sennott, Erin M\|Van Allen, Eliezer M\|Wagle, Nikhil\|Kwak, Eunice L\|Faris, Jason E\|Godfrey, Jason T\|Nishimura, Koki\|Lynch, Kerry D\|Mermel, Craig H\|Lockerman, Elizabeth L\|Kalsy, Anuj\|Gurski, Joseph M Jr\|Bahl, Samira\|Anderka, Kristin\|Green,
PMID:	25673644

246.
Journal:	Cancer Biol Ther. 2015;16(1):34-42.
Title:	The preclinical evaluation of the dual mTORC1/2 inhibitor INK-128 as a potential anti-colorectal cancer agent.
Author:	Li, Chen\|Cui, Jian-Feng\|Chen, Min-Bin\|Liu, Chao-Ying\|Liu, Feng\|Zhang, Qian-De\|Zou, Jian\|Lu, Pei-Hua
PMID:	25692620

247.
Journal:	Anticancer Res. 2015 Mar;35(3):1377-84.
Title:	PCK3145 inhibits proliferation and induces apoptosis in breast and colon cancer cells.
Author:	Kostopoulos, Antonios\|Papageorgiou, Efstathia\|Koutsilieris, Michael\|Sivolapenko, Gregory
PMID:	25750288

248.
Journal:	Cancer Biol Ther. 2015;16(4):511-7.
Title:	HMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathway.
Author:	Liu, Weijun\|Zhang, Zhenyong\|Zhang, Yongxue\|Chen, Xinju\|Guo, Shikui\|Lei, Yi\|Xu, Yu\|Ji, Chao\|Bi, Zhigang\|Wang, Kunhua
PMID:	25778491

249.
Journal:	Front Oncol. 2015 Mar 3;5:54.
Title:	Current Understanding of BRAF Alterations in Diagnosis, Prognosis, and Therapeutic Targeting in Pediatric Low-Grade Gliomas.
Author:	Penman, Catherine Louise\|Faulkner, Claire\|Lowis, Stephen P\|Kurian, Kathreena M
PMID:	25785246

250.
Journal:	Am J Pathol. 2015 Apr;185(4):1135-44.
Title:	Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells.
Author:	Peng, Hui\|Li, Tony W H\|Yang, Heping\|Moyer, Mary P\|Mato, Jose M\|Lu, Shelly C
PMID:	25794709

251.
Journal:	Clin Cancer Res. 2015 Jul 15;21(14):3230-3240.
Title:	HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL.
Author:	Carson, Robbie\|Celtikci, Basak\|Fenning, Cathy\|Javadi, Arman\|Crawford, Nyree\|Carbonell, Lucia Perez\|Lawler, Mark\|Longley, Daniel B\|Johnston, Patrick G\|Van Schaeybroeck, Sandra
PMID:	25813020

252.
Journal:	Cancer Discov. 2015 Apr;5(4):348-50.
Title:	Old Habits Die Hard: Addiction of BRAF-Mutant Cancer Cells to MAP Kinase Signaling.
Author:	Meador, Catherine B\|Pao, William
PMID:	25847954

253.
Journal:	Cancer Sci. 2015 Jun;106(6):692-9.
Title:	Antitumor activity of the MEK inhibitor trametinib on intestinal polyp formation in Apc(Delta716) mice involves stromal COX-2.
Author:	Fujishita, Teruaki\|Kajino-Sakamoto, Rie\|Kojima, Yasushi\|Taketo, Makoto Mark\|Aoki, Masahiro
PMID:	25855137

254.
Journal:	Clin Colorectal Cancer. 2015 Sep;14(3):154-61.
Title:	A Phase II Study of Sorafenib Combined With Cetuximab in EGFR-Expressing, KRAS-Mutated Metastatic Colorectal Cancer.
Author:	Do, Khanh\|Cao, Liang\|Kang, Zhigang\|Turkbey, Baris\|Lindenberg, Maria L\|Larkins, Erin\|Holkova, Beata\|Steinberg, Seth M\|Raffeld, Mark\|Peer, Cody J\|Figg, William D\|Eugeni, Michelle\|Jacobs, Paula\|Choyke, Peter\|Wright, John J\|Doroshow, James H\|Kummar, Shivaani
PMID:	25861837

255.
Journal:	Mol Cancer. 2015 Apr 11;14:80.
Title:	Preclinical analysis of the anti-tumor and anti-metastatic effects of Raf265 on colon cancer cells and CD26(+) cancer stem cells in colorectal carcinoma.
Author:	Chow, Ariel K M\|Cheng, Nathan S M\|Lam, Colin S C\|Ng, Lui\|Wong, Sunny K M\|Wan, Timothy M H\|Man, Johnny H W\|Cheung, Alvin H K\|Yau, Thomas C C\|Poon, Jensen T C\|Law, Wai-Lun\|Pang, Roberta W C
PMID:	25884645

256.
Journal:	BMC Cancer. 2015 Apr 8;15:240.
Title:	HGUE-C-1 is an atypical and novel colon carcinoma cell line.
Author:	Grasso, Silvina\|Martinez-Lacaci, Isabel\|Barbera, Victor Manuel\|Castillejo, Adela\|Soto, Jose Luis\|Gallego-Plazas, Javier\|Lopez-Riquelme, Natividad\|Garcia-Morales, Pilar\|Mata-Balaguer, Trinidad\|Ferragut, Jose Antonio\|Saceda, Miguel
PMID:	25885658

257.
Journal:	J Transl Med. 2015 Feb 12;13:57.
Title:	Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib.
Author:	Wong, Andrea Li Ann\|Lim, Joline Si Jing\|Sinha, Arvind\|Gopinathan, Anil\|Lim, Robert\|Tan, Chee-Seng\|Soh, Thomas\|Venkatesh, Sudhakar\|Titin, Christina\|Sapari, Nur Sabrina\|Lee, Soo-Chin\|Yong, Wei-Peng\|Tan, David Shao Ping\|Pang, Brendan\|Wang, Ting-Ting\|Zee, Yin
PMID:	25889309

258.
Journal:	Mol Oncol. 2015 Aug;9(7):1434-46.
Title:	KRAS and HRAS mutations confer resistance to MET targeting in preclinical models of MET-expressing tumor cells.
Author:	Leiser, Dominic\|Medova, Michaela\|Mikami, Kei\|Nisa, Lluis\|Stroka, Deborah\|Blaukat, Andree\|Bladt, Friedhelm\|Aebersold, Daniel M\|Zimmer, Yitzhak
PMID:	25933688

259.
Journal:	Mol Cancer Res. 2015 Aug;13(8):1248-62.
Title:	Colorectal Carcinogenesis: Connecting K-RAS-Induced Transformation and CREB Activity In Vitro and In Vivo.
Author:	Steven, Andre\|Heiduk, Max\|Recktenwald, Christian V\|Hiebl, Bernhard\|Wickenhauser, Claudia\|Massa, Chiara\|Seliger, Barbara
PMID:	25934695

260.
Journal:	Cancer Immunol Res. 2015 Sep;3(9):1052-62.
Title:	Identification and Characterization of MEDI4736, an Antagonistic Anti-PD-L1 Monoclonal Antibody.
Author:	Stewart, Ross\|Morrow, Michelle\|Hammond, Scott A\|Mulgrew, Kathy\|Marcus, Danielle\|Poon, Edmund\|Watkins, Amanda\|Mullins, Stefanie\|Chodorge, Matthieu\|Andrews, John\|Bannister, David\|Dick, Emily\|Crawford, Nicola\|Parmentier, Julie\|Alimzhanov, Marat\|Babcook, John
PMID:	25943534

261.
Journal:	Oncotarget. 2015 Jun 10;6(16):14472-87.
Title:	Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells.
Author:	Zhao, Chengguang\|Xiao, Hui\|Wu, Xiaojuan\|Li, Chenglong\|Liang, Guang\|Yang, Shulin\|Lin, Jiayuh
PMID:	25961376

262.
Journal:	Semin Oncol. 2015 Jun;42(3):474-83.
Title:	PD-L1 blockade for cancer treatment: MEDI4736.
Author:	Ibrahim, Ramy\|Stewart, Ross\|Shalabi, Aiman
PMID:	25965366

263.
Journal:	Am J Cancer Res. 2015 Jan 15;5(2):560-74. eCollection 2015.
Title:	Prominin-1 (CD133, AC133) and dipeptidyl-peptidase IV (CD26) are indicators of infinitive growth in colon cancer cells.
Author:	Grunt, Thomas W\|Hebar, Alexandra\|Laffer, Sylvia\|Wagner, Renate\|Peter, Barbara\|Herrmann, Harald\|Graf, Alexandra\|Bilban, Martin\|Posch, Martin\|Hoermann, Gregor\|Mayerhofer, Matthias\|Eisenwort, Gregor\|Zielinski, Christoph C\|Selzer, Edgar\|Valent, Peter
PMID:	25973297

264.
Journal:	Oncotarget. 2015 May 10;6(13):10994-1008.
Title:	Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway.
Author:	Conti, Annalisa\|Majorini, Maria Teresa\|Elliott, Richard\|Ashworth, Alan\|Lord, Christopher J\|Cancelliere, Carlotta\|Bardelli, Alberto\|Seneci, Pierfausto\|Walczak, Henning\|Delia, Domenico\|Lecis, Daniele
PMID:	26028667

265.
Journal:	Mar Drugs. 2015 Jun 5;13(6):3625-39.
Title:	Activation of RAF1 (c-RAF) by the Marine Alkaloid Lasonolide A Induces Rapid Premature Chromosome Condensation.
Author:	Josse, Rozenn\|Zhang, Yong-Wei\|Giroux, Valentin\|Ghosh, Arun K\|Luo, Ji\|Pommier, Yves
PMID:	26058013

266.
Journal:	Front Pharmacol. 2015 Jun 16;6:120.
Title:	Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models.
Author:	Davis, S Lindsey\|Robertson, Kelli M\|Pitts, Todd M\|Tentler, John J\|Bradshaw-Pierce, Erica L\|Klauck, Peter J\|Bagby, Stacey M\|Hyatt, Stephanie L\|Selby, Heather M\|Spreafico, Anna\|Ecsedy, Jeffrey A\|Arcaroli, John J\|Messersmith, Wells A\|Tan, Aik Choon\|Eckhardt,
PMID:	26136684

267.
Journal:	Cancer Sci. 2015 Oct;106(10):1278-87.
Title:	FGF-1/-3/FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP-7.
Author:	Bai, Yu-Pan\|Shang, Kun\|Chen, Huan\|Ding, Fei\|Wang, Zhen\|Liang, Chen\|Xu, Ye\|Sun, Meng-Hong\|Li, Ying-Yi
PMID:	26183471

268.
Journal:	FEBS Lett. 2015 Aug 19;589(18):2388-93.
Title:	The S100P/RAGE signaling pathway regulates expression of microRNA-21 in colon cancer cells.
Author:	Mercado-Pimentel, Melania E\|Onyeagucha, Benjamin C\|Li, Qing\|Pimentel, Angel C\|Jandova, Jana\|Nelson, Mark A
PMID:	26193421

269.
Journal:	J Biol Chem. 2015 Sep 25;290(39):23838-49.
Title:	The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism.
Author:	Zaanan, Aziz\|Okamoto, Koichi\|Kawakami, Hisato\|Khazaie, Khashayarsha\|Huang, Shengbing\|Sinicrope, Frank A
PMID:	26245900

270.
Journal:	Oncogenesis. 2015 Aug 10;4:e162.
Title:	SPINK1 promotes colorectal cancer progression by downregulating Metallothioneins expression.
Author:	Tiwari, R\|Pandey, S K\|Goel, S\|Bhatia, V\|Shukla, S\|Jing, X\|Dhanasekaran, S M\|Ateeq, B
PMID:	26258891

271.
Journal:	Clin Cancer Res. 2015 Dec 15;21(24):5499-5510.
Title:	MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer.
Author:	Garcia-Garcia, Celina\|Rivas, Martin A\|Ibrahim, Yasir H\|Calvo, Maria Teresa\|Gris-Oliver, Albert\|Rodriguez, Olga\|Grueso, Judit\|Anton, Pilar\|Guzman, Marta\|Aura, Claudia\|Nuciforo, Paolo\|Jessen, Katti\|Argiles, Guillem\|Dienstmann, Rodrigo\|Bertotti, Andrea\|Truso
PMID:	26272063

272.
Journal:	PLoS One. 2015 Aug 21;10(8):e0136080.
Title:	Multidrug Resistance-Associated Protein 2 Expression Is Upregulated by Adenosine 5'-Triphosphate in Colorectal Cancer Cells and Enhances Their Survival to Chemotherapeutic Drugs.
Author:	Vinette, Valerie\|Placet, Morgane\|Arguin, Guillaume\|Gendron, Fernand-Pierre
PMID:	26295158

273.
Journal:	Nat Commun. 2015 Aug 24;6:8022.
Title:	Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signalling pathway.
Author:	Song, Wei\|Liu, Wenjie\|Zhao, Hong\|Li, Shangze\|Guan, Xin\|Ying, Jianming\|Zhang, Yefan\|Miao, Fei\|Zhang, Mengmeng\|Ren, Xiaoxia\|Li, Xiaolu\|Wu, Fan\|Zhao, Yuechao\|Tian, Yuanyuan\|Wu, Wenming\|Fu, Jun\|Liang, Junbo\|Wu, Wei\|Liu, Changzheng\|Yu, Jia\|Zong, Shudong\|Miao,
PMID:	26300397

274.
Journal:	Mol Cancer Ther. 2015 Dec;14(12):2700-11.
Title:	Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors.
Author:	Whittaker, Steven R\|Cowley, Glenn S\|Wagner, Steve\|Luo, Flora\|Root, David E\|Garraway, Levi A
PMID:	26351322

275.
Journal:	J Clin Oncol. 2015 Dec 1;33(34):4023-31.
Title:	Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer.
Author:	Corcoran, Ryan B\|Atreya, Chloe E\|Falchook, Gerald S\|Kwak, Eunice L\|Ryan, David P\|Bendell, Johanna C\|Hamid, Omid\|Messersmith, Wells A\|Daud, Adil\|Kurzrock, Razelle\|Pierobon, Mariaelena\|Sun, Peng\|Cunningham, Elizabeth\|Little, Shonda\|Orford, Keith\|Motwani, Mo
PMID:	26392102

276.
Journal:	Nat Commun. 2015 Sep 22;6:8305.
Title:	Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers.
Author:	Misale, Sandra\|Bozic, Ivana\|Tong, Jingshan\|Peraza-Penton, Ashley\|Lallo, Alice\|Baldi, Federica\|Lin, Kevin H\|Truini, Mauro\|Trusolino, Livio\|Bertotti, Andrea\|Di Nicolantonio, Federica\|Nowak, Martin A\|Zhang, Lin\|Wood, Kris C\|Bardelli, Alberto
PMID:	26392303

277.
Journal:	Int J Mol Sci. 2015 Sep 23;16(9):22976-88.
Title:	Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal Cancers.
Author:	Temraz, Sally\|Mukherji, Deborah\|Shamseddine, Ali
PMID:	26404261

278.
Journal:	J Exp Clin Cancer Res. 2015 Oct 1;34:108.
Title:	Cancer-related CD15/FUT4 overexpression decreases benefit to agents targeting EGFR or VEGF acting as a novel RAF-MEK-ERK kinase downstream regulator in metastatic colorectal cancer.
Author:	Giordano, Guido\|Febbraro, Antonio\|Tomaselli, Eugenio\|Sarnicola, Maria Lucia\|Parcesepe, Pietro\|Parente, Domenico\|Forte, Nicola\|Fabozzi, Alessio\|Remo, Andrea\|Bonetti, Andrea\|Manfrin, Erminia\|Ghasemi, Somayehsadat\|Ceccarelli, Michele\|Cerulo, Luigi\|Bazzoni, F
PMID:	26427914

279.
Journal:	Oncotarget. 2015 Oct 27;6(33):34561-72.
Title:	Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts.
Author:	Lieu, Christopher H\|Klauck, Peter J\|Henthorn, Patrick K\|Tentler, John J\|Tan, Aik-Choon\|Spreafico, Anna\|Selby, Heather M\|Britt, Blair C\|Bagby, Stacey M\|Arcaroli, John J\|Messersmith, Wells A\|Pitts, Todd M\|Eckhardt, S Gail
PMID:	26439693

280.
Journal:	Curr Cancer Drug Targets. 2015;15(8):703-15.
Title:	Prognostic and Predictive Biomarkers in Colorectal Cancer. From the Preclinical Setting to Clinical Practice.
Author:	Maurel, Joan\|Postigo, Antonio
PMID:	26452385

281.
Journal:	J Control Release. 2015 Dec 28;220(Pt A):160-168.
Title:	Cytotoxicity of PEGylated liposomes co-loaded with novel pro-apoptotic drug NCL-240 and the MEK inhibitor cobimetinib against colon carcinoma in vitro.
Author:	Sriraman, Shravan Kumar\|Geraldo, Vananelia\|Luther, Ed\|Degterev, Alexei\|Torchilin, Vladimir
PMID:	26497930

282.
Journal:	BMC Cancer. 2015 Oct 24;15:779.
Title:	Clinical detection and categorization of uncommon and concomitant mutations involving BRAF.
Author:	Zheng, Gang\|Tseng, Li-Hui\|Chen, Guoli\|Haley, Lisa\|Illei, Peter\|Gocke, Christopher D\|Eshleman, James R\|Lin, Ming-Tseh
PMID:	26498038

283.
Journal:	PLoS One. 2015 Nov 23;10(11):e0142612.
Title:	Regorafenib: Antitumor Activity upon Mono and Combination Therapy in Preclinical Pediatric Malignancy Models.
Author:	Daudigeos-Dubus, Estelle\|Le Dret, Ludivine\|Lanvers-Kaminsky, Claudia\|Bawa, Olivia\|Opolon, Paule\|Vievard, Albane\|Villa, Irene\|Pages, Melanie\|Bosq, Jacques\|Vassal, Gilles\|Zopf, Dieter\|Geoerger, Birgit
PMID:	26599335

284.
Journal:	Pharmacogenomics. 2015 Dec;16(18):2069-81.
Title:	BRAF in metastatic colorectal cancer: the future starts now.
Author:	Orlandi, Armando\|Calegari, Alessandra\|Inno, Alessandro\|Berenato, Rosa\|Caporale, Marta\|Niger, Monica\|Bossi, Ilaria\|Di Bartolomeo, Maria\|de Braud, Filippo\|Pietrantonio, Filippo
PMID:	26615988

285.
Journal:	J Cell Biochem. 2016 Jan;117(1):172-9.
Title:	PRDM1, a Tumor-Suppressor Gene, is Induced by Genkwadaphnin in Human Colon Cancer SW620 Cells.
Author:	Kang, Ho-Bum\|Lee, Ha-Reum\|Jee, Da Jung\|Shin, Su-Hyun\|Nah, Seong-Su\|Yoon, Sun Young\|Kim, Jae Wha
PMID:	26096175

286.
Journal:	Acta Biochim Biophys Sin (Shanghai). 2016 Jan;48(1):27-38.
Title:	RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
Author:	Fang, Bingliang
PMID:	26350096

287.
Journal:	Clin Cancer Res. 2016 Jan 15;22(2):405-14.
Title:	Sensitivity of KRAS-Mutant Colorectal Cancers to Combination Therapy That Cotargets MEK and CDK4/6.
Author:	Ziemke, Elizabeth K\|Dosch, Joseph S\|Maust, Joel D\|Shettigar, Amrith\|Sen, Ananda\|Welling, Theodore H\|Hardiman, Karin M\|Sebolt-Leopold, Judith S
PMID:	26369631

288.
Journal:	Oncol Rep. 2016 Jan;35(1):107-16.
Title:	Lauric acid can improve the sensitization of Cetuximab in KRAS/BRAF mutated colorectal cancer cells by retrievable microRNA-378 expression.
Author:	Weng, Wen-Hui\|Leung, Wai-Hung\|Pang, Yeu-Jye\|Hsu, Hsi-Hsien
PMID:	26496897

289.
Journal:	Cancer Discov. 2016 Feb;6(2):147-153.
Title:	Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer.
Author:	Russo, Mariangela\|Siravegna, Giulia\|Blaszkowsky, Lawrence S\|Corti, Giorgio\|Crisafulli, Giovanni\|Ahronian, Leanne G\|Mussolin, Benedetta\|Kwak, Eunice L\|Buscarino, Michela\|Lazzari, Luca\|Valtorta, Emanuele\|Truini, Mauro\|Jessop, Nicholas A\|Robinson, Hayley E\|H
PMID:	26644315

290.
Journal:	Clin Cancer Res. 2016 May 15;22(10):2368-76.
Title:	A Phase I Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Combination Therapy with Refametinib plus Sorafenib in Patients with Advanced Cancer.
Author:	Adjei, Alex A\|Richards, Donald A\|El-Khoueiry, Anthony\|Braiteh, Fadi\|Becerra, Carlos H R\|Stephenson, Joe J Jr\|Hezel, Aram F\|Sherman, Morris\|Garbo, Lawrence\|Leffingwell, Diane P\|Iverson, Cory\|Miner, Jeffrey N\|Shen, Zancong\|Yeh, Li-Tain\|Gunawan, Sonny\|Wilson
PMID:	26644411

291.
Journal:	Invest New Drugs. 2016 Apr;34(2):168-75.
Title:	A phase I study of selumetinib (AZD6244/ARRY-142866), a MEK1/2 inhibitor, in combination with cetuximab in refractory solid tumors and KRAS mutant colorectal cancer.
Author:	Deming, Dustin A\|Cavalcante, Ludmila L\|Lubner, Sam J\|Mulkerin, Daniel L\|LoConte, Noelle K\|Eickhoff, Jens C\|Kolesar, Jill M\|Fioravanti, Suzanne\|Greten, Tim F\|Compton, Kathryn\|Doyle, Austin G\|Wilding, George\|Duffy, Austin\|Liu, Glenn
PMID:	26666244

292.
Journal:	J Pathol. 2016 Mar;238(4):562-70.
Title:	HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials.
Author:	Richman, Susan D\|Southward, Katie\|Chambers, Philip\|Cross, Debra\|Barrett, Jennifer\|Hemmings, Gemma\|Taylor, Morag\|Wood, Henry\|Hutchins, Gordon\|Foster, Joseph M\|Oumie, Assa\|Spink, Karen G\|Brown, Sarah R\|Jones, Marc\|Kerr, David\|Handley, Kelly\|Gray, Richard\|Se
PMID:	26690310

293.
Journal:	J Exp Clin Cancer Res. 2016 Jan 12;35:5.
Title:	Gab2 facilitates epithelial-to-mesenchymal transition via the MEK/ERK/MMP signaling in colorectal cancer.
Author:	Ding, Chenbo\|Luo, Junmin\|Li, Longmei\|Li, Shanshan\|Yang, Liwen\|Pan, Hongfei\|Liu, Qianyi\|Qin, Huan\|Chen, Chao\|Feng, Jihong
PMID:	26754532

294.
Journal:	Nanomedicine (Lond). 2016 Feb;11(4):331-44.
Title:	Efficacy of DOPE/DC-cholesterol liposomes and GCPQ micelles as AZD6244 nanocarriers in a 3D colorectal cancer in vitro model.
Author:	Lopez-Davila, Victor\|Magdeldin, Tarig\|Welch, Hazel\|Dwek, Miriam Victoria\|Uchegbu, Ijeoma\|Loizidou, Marilena
PMID:	26786002

295.
Journal:	PLoS One. 2016 Jan 20;11(1):e0144970.
Title:	Exploiting the CRISPR/Cas9 PAM Constraint for Single-Nucleotide Resolution Interventions.
Author:	Li, Yi\|Mendiratta, Saurabh\|Ehrhardt, Kristina\|Kashyap, Neha\|White, Michael A\|Bleris, Leonidas
PMID:	26788852

296.
Journal:	Oncotarget. 2016 Feb 23;7(8):9188-221.
Title:	BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells.
Author:	Goulielmaki, Maria\|Koustas, Evangelos\|Moysidou, Eirini\|Vlassi, Margarita\|Sasazuki, Takehiko\|Shirasawa, Senji\|Zografos, George\|Oikonomou, Eftychia\|Pintzas, Alexander
PMID:	26802026

297.
Journal:	Cancer Biol Ther. 2016;17(2):199-207.
Title:	EBI-907, a novel BRAF(V600E) inhibitor, has potent oral anti-tumor activity and a broad kinase selectivity profile.
Author:	Zhang, Jiayin\|Lu, Biao\|Liu, Dong\|Shen, Ru\|Yan, Yinfa\|Yang, Liuqing\|Zhang, Minsheng\|Zhang, Lei\|Cao, Guoqing\|Cao, Hu\|Fu, Beibei\|Gong, Aishen\|Sun, Qiming\|Wan, Hong\|Zhang, Lianshan\|Tao, Weikang\|Cao, Jingsong
PMID:	26810733

298.
Journal:	Eur J Cancer. 2016 Mar;56:69-76.
Title:	Pre-clinical use of isogenic cell lines and tumours in vitro and in vivo for predictive biomarker discovery; impact of KRAS and PI3KCA mutation status on MEK inhibitor activity is model dependent.
Author:	Haagensen, Emma J\|Thomas, Huw D\|Mudd, Clare\|Tsonou, Elpida\|Wiggins, Ceri M\|Maxwell, Ross J\|Moore, Jonathan D\|Newell, David R
PMID:	26820797

299.
Journal:	BMC Syst Biol. 2016 Feb 11;10:16.
Title:	Integrative modeling of multi-omics data to identify cancer drivers and infer patient-specific gene activity.
Author:	Pavel, Ana B\|Sonkin, Dmitriy\|Reddy, Anupama
PMID:	26864072

300.
Journal:	Cancer Genomics Proteomics. 2016 Mar-Apr;13(2):141-50.
Title:	GeneGazer: A Toolkit Integrating Two Pipelines for Personalized Profiling and Biosignature Identification.
Author:	Luo, Ji-Dung\|Chang, Yu-Jia\|Chang, Chung-Ming\|You, Jeng-Fu\|Wei, Po-Li\|Chiou, Chiuan-Chian
PMID:	26912804

301.
Journal:	Oncotarget. 2016 Mar 29;7(13):16349-61.
Title:	AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin.
Author:	Gao, Mei\|Kong, Qingbin\|Hua, Hui\|Yin, Yancun\|Wang, Jiao\|Luo, Ting\|Jiang, Yangfu
PMID:	26918349

302.
Journal:	Asian Pac J Cancer Prev. 2016;17(2):743-8.
Title:	Impact of Cellular Genetic Make-up on Colorectal Cancer Cell Lines Response to Ellagic Acid: Implications of Small Interfering RNA.
Author:	Yousef, Amany I\|El-Masry, Omar S\|Abdel Mohsen, Mohamed A
PMID:	26925673

303.
Journal:	Cell Cycle. 2016;15(4):506-18.
Title:	Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.
Author:	Lochhead, Pamela A\|Clark, Jonathan\|Wang, Lan-Zhen\|Gilmour, Lesley\|Squires, Matthew\|Gilley, Rebecca\|Foxton, Caroline\|Newell, David R\|Wedge, Stephen R\|Cook, Simon J
PMID:	26959608

304.
Journal:	Mol Cancer Ther. 2016 Jun;15(6):1217-26.
Title:	Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.
Author:	Togel, Lars\|Nightingale, Rebecca\|Chueh, Anderly C\|Jayachandran, Aparna\|Tran, Hoanh\|Phesse, Toby\|Wu, Rui\|Sieber, Oliver M\|Arango, Diego\|Dhillon, Amardeep S\|Dawson, Mark A\|Diez-Dacal, Beatriz\|Gahman, Timothy C\|Filippakopoulos, Panagis\|Shiau, Andrew K\|Mariad
PMID:	26983878

305.
Journal:	Cancer Discov. 2016 Jun;6(6):594-600.
Title:	BRAFV600E Mutations in High-Grade Colorectal Neuroendocrine Tumors May Predict Responsiveness to BRAF-MEK Combination Therapy.
Author:	Klempner, Samuel J\|Gershenhorn, Bruce\|Tran, Phu\|Lee, Thomas K\|Erlander, Mark G\|Gowen, Kyle\|Schrock, Alexa B\|Morosini, Deborah\|Ross, Jeffrey S\|Miller, Vincent A\|Stephens, Philip J\|Ou, Sai-Hong Ignatius\|Ali, Siraj M
PMID:	27048246

306.
Journal:	J Cancer Res Ther. 2016 Jan-Mar;12(1):96-102.
Title:	The association of clinicopathological features and survival in colorectal cancer patients with kras mutation status.
Author:	Akman, Tulay\|Oztop, Ilhan\|Baskin, Yasemin\|Unek, Ilkay Tugba\|Demir, Necla\|Ellidokuz, Hulya\|Yilmaz, Ahmet Ugur
PMID:	27072218

307.
Journal:	Oncotarget. 2016 May 17;7(20):29187-98.
Title:	Acquired resistance to combination treatment through loss of synergy with MEK and PI3K inhibitors in colorectal cancer.
Author:	Bhattacharya, Bhaskar\|Low, Sarah Hong Hui\|Chong, Mei Ling\|Chia, Dilys\|Koh, King Xin\|Sapari, Nur Sabrina\|Kaye, Stanley\|Hung, Huynh\|Benoukraf, Touati\|Soong, Richie
PMID:	27081080

308.
Journal:	Medicine (Baltimore). 2016 Apr;95(15):e3321.
Title:	MicroRNA Expression Signatures Associated With BRAF-Mutated Versus KRAS-Mutated Colorectal Cancers.
Author:	Choi, Yong Won\|Song, Young Soo\|Lee, Hyunwoo\|Yi, Kijong\|Kim, Young-Bae\|Suh, Kwang Wook\|Lee, Dakeun
PMID:	27082577

309.
Journal:	Sci Rep. 2016 Apr 20;6:24720.
Title:	miRs-134 and -370 function as tumor suppressors in colorectal cancer by independently suppressing EGFR and PI3K signalling.
Author:	El-Daly, Sherien M\|Abba, Mohammed L\|Patil, Nitin\|Allgayer, Heike
PMID:	27095166

310.
Journal:	Onco Targets Ther. 2016 Mar 31;9:1899-920.
Title:	Advances in targeted and immunobased therapies for colorectal cancer in the genomic era.
Author:	Seow, Heng Fong\|Yip, Wai Kien\|Fifis, Theodora
PMID:	27099521

311.
Journal:	Am J Transl Res. 2016 Feb 15;8(2):742-8. eCollection 2016.
Title:	BRD7: a novel tumor suppressor gene in different cancers.
Author:	Yu, Xin\|Li, Zheng\|Shen, Jianxiong
PMID:	27158366

312.
Journal:	Oncotarget. 2016 Jun 28;7(26):39595-39608.
Title:	Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models.
Author:	Lee, Michael S\|Helms, Timothy L\|Feng, Ningping\|Gay, Jason\|Chang, Qing Edward\|Tian, Feng\|Wu, Ji Y\|Toniatti, Carlo\|Heffernan, Timothy P\|Powis, Garth\|Kwong, Lawrence N\|Kopetz, Scott
PMID:	27167191

313.
Journal:	J Cell Biochem. 2016 Dec;117(12):2875-2885.
Title:	Resistance to 3-HTMC-Induced Apoptosis Through Activation of PI3K/Akt, MEK/ERK, and p38/COX-2/PGE2 Pathways in Human HT-29 and HCT116 Colorectal Cancer Cells.
Author:	Semaan, Josiane\|Pinon, Aline\|Rioux, Benjamin\|Hassan, Lama\|Limami, Youness\|Pouget, Christelle\|Fagnere, Catherine\|Sol, Vincent\|Diab-Assaf, Mona\|Simon, Alain\|Liagre, Bertrand
PMID:	27192488

314.
Journal:	Oncotarget. 2016 Jun 21;7(25):38143-38153.
Title:	Down-regulation of tensin2 enhances tumorigenicity and is associated with a variety of cancers.
Author:	Hong, Shiao-Ya\|Shih, Yi-Ping\|Sun, Peng\|Hsieh, Wang-Ju\|Lin, Wen-Chang\|Lo, Su Hao
PMID:	27203214

315.
Journal:	Dev Reprod. 2016 Mar;20(1):1-10.
Title:	Blockage of Autophagy Rescues the Dual PI3K/mTOR Inhibitor BEZ235-induced Growth Inhibition of Colorectal Cancer Cells.
Author:	Oh, Iljoong\|Cho, Hyunchul\|Lee, Yonghoon\|Cheon, Minseok\|Park, Deokbae\|Lee, Youngki
PMID:	27294206

316.
Journal:	Cancer Res. 2016 Aug 1;76(15):4504-15.
Title:	Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer.
Author:	Oddo, Daniele\|Sennott, Erin M\|Barault, Ludovic\|Valtorta, Emanuele\|Arena, Sabrina\|Cassingena, Andrea\|Filiciotto, Genny\|Marzolla, Giulia\|Elez, Elena\|van Geel, Robin M J M\|Bartolini, Alice\|Crisafulli, Giovanni\|Boscaro, Valentina\|Godfrey, Jason T\|Buscarino, M
PMID:	27312529

317.
Journal:	Nature. 2016 Jun 30;534(7609):647-51.
Title:	A combinatorial strategy for treating KRAS-mutant lung cancer.
Author:	Manchado, Eusebio\|Weissmueller, Susann\|Morris, John P 4th\|Chen, Chi-Chao\|Wullenkord, Ramona\|Lujambio, Amaia\|de Stanchina, Elisa\|Poirier, John T\|Gainor, Justin F\|Corcoran, Ryan B\|Engelman, Jeffrey A\|Rudin, Charles M\|Rosen, Neal\|Lowe, Scott W
PMID:	27338794

318.
Journal:	Oncotarget. 2016 Jul 26;7(30):47699-47710.
Title:	BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells.
Author:	He, Kan\|Chen, Dongshi\|Ruan, Hang\|Li, Xiangyun\|Tong, Jingshan\|Xu, Xiang\|Zhang, Lin\|Yu, Jian
PMID:	27351224

319.
Journal:	Biochem Biophys Res Commun. 2016 Sep 2;477(4):801-806.
Title:	Involvement of the MEK/ERK pathway in EGF-induced E-cadherin down-regulation.
Author:	Tashiro, Etsu\|Henmi, Shizuka\|Odake, Hiroyuki\|Ino, Seitaro\|Imoto, Masaya
PMID:	27369075

320.
Journal:	J Biomol Screen. 2016 Oct;21(9):989-97.
Title:	Development of a High-Throughput Gene Expression Screen for Modulators of RAS-MAPK Signaling in a Mutant RAS Cellular Context.
Author:	Severyn, Bryan\|Nguyen, Thi\|Altman, Michael D\|Li, Lixia\|Nagashima, Kumiko\|Naumov, George N\|Sathyanarayanan, Sriram\|Cook, Erica\|Morris, Erick\|Ferrer, Marc\|Arthur, Bill\|Benita, Yair\|Watters, Jim\|Loboda, Andrey\|Hermes, Jeff\|Gilliland, D Gary\|Cleary, Michelle
PMID:	27461835

321.
Journal:	Clin Cancer Res. 2016 Aug 1;22(15):3982.
Title:	Correction: MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer.
Author:
PMID:	27480870

322.
Journal:	Anticancer Res. 2016 Sep;36(9):4537-43.
Title:	MEK Inhibitor Suppresses Expression of the miR-17-92 Cluster with G1-Phase Arrest in HT-29 Human Colon Cancer Cells and MIA PaCa-2 Pancreatic Cancer Cells.
Author:	Tanaka, Ryoichi\|Tomosugi, Mitsuhiro\|Sakai, Toshiyuki\|Sowa, Yoshihiro
PMID:	27630293

323.
Journal:	Tumour Biol. 2016 Nov;37(11):14885-14894.
Title:	gamma-Aminobutyric acid inhibits the proliferation and increases oxaliplatin sensitivity in human colon cancer cells.
Author:	Song, Lihua\|Du, Aiying\|Xiong, Ying\|Jiang, Jing\|Zhang, Yao\|Tian, Zhaofeng\|Yan, Hongli
PMID:	27644246

324.
Journal:	Cell Death Discov. 2016 Sep 12;2:16067.
Title:	Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis.
Author:	Carr, Ryan M\|Qiao, Guilin\|Qin, Jianzhong\|Jayaraman, Sundararajan\|Prabhakar, Bellur S\|Maker, Ajay V
PMID:	27648301

325.
Journal:	Mol Cancer Res. 2016 Dec;14(12):1204-1216.
Title:	MEK and TAK1 Regulate Apoptosis in Colon Cancer Cells with KRAS-Dependent Activation of Proinflammatory Signaling.
Author:	McNew, Kelsey L\|Whipple, William J\|Mehta, Anita K\|Grant, Trevor J\|Ray, Leah\|Kenny, Connor\|Singh, Anurag
PMID:	27655129

326.
Journal:	Oncotarget. 2016 Oct 25;7(43):70589-70600.
Title:	RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis.
Author:	Bond, Catherine E\|McKeone, Diane M\|Kalimutho, Murugan\|Bettington, Mark L\|Pearson, Sally-Ann\|Dumenil, Troy D\|Wockner, Leesa F\|Burge, Matthew\|Leggett, Barbara A\|Whitehall, Vicki L J
PMID:	27661107

327.
Journal:	Oncotarget. 2016 Nov 1;7(44):71400-71416.
Title:	STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways.
Author:	Chen, Bing\|Zeng, Xiao\|He, Yu\|Wang, Xixi\|Liang, Ziwei\|Liu, Jingjing\|Zhang, Peng\|Zhu, Hongxia\|Xu, Ningzhi\|Liang, Shufang
PMID:	27662663

328.
Journal:	Eur J Cancer. 2016 Nov;68:38-50.
Title:	6-C-(E-phenylethenyl)naringenin induces cell growth inhibition and cytoprotective autophagy in colon cancer cells.
Author:	Zhao, Yueliang\|Fan, Daming\|Ru, Beibei\|Cheng, Ka-Wing\|Hu, Shuting\|Zhang, Jiangwen\|Li, Edmund T S\|Wang, Mingfu
PMID:	27710830

329.
Journal:	Sci Signal. 2016 Oct 11;9(449):rs11.
Title:	Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks.
Author:	Simmons, Alan J\|Scurrah, Cherie R\|McKinley, Eliot T\|Herring, Charles A\|Irish, Jonathan M\|Washington, M Kay\|Coffey, Robert J\|Lau, Ken S
PMID:	27729552

330.
Journal:	J Gastrointest Oncol. 2016 Oct;7(5):687-704.
Title:	RAS and BRAF in metastatic colorectal cancer management.
Author:	Gong, Jun\|Cho, May\|Fakih, Marwan
PMID:	27747083

331.
Journal:	Mol Cancer Ther. 2016 Dec;15(12):3015-3027.
Title:	Mutant BRAF Upregulates MCL-1 to Confer Apoptosis Resistance that Is Reversed by MCL-1 Antagonism and Cobimetinib in Colorectal Cancer.
Author:	Kawakami, Hisato\|Huang, Shengbing\|Pal, Krishnendu\|Dutta, Shamit K\|Mukhopadhyay, Debabrata\|Sinicrope, Frank A
PMID:	27765849

332.
Journal:	Oncotarget. 2016 Dec 13;7(50):83017-83030.
Title:	PRIMA-1Met suppresses colorectal cancer independent of p53 by targeting MEK.
Author:	Lu, Tao\|Zou, Yanmei\|Xu, Guogang\|Potter, Jane A\|Taylor, Garry L\|Duan, Qiuhong\|Yang, Qin\|Xiong, Huihua\|Qiu, Hong\|Ye, Dawei\|Zhang, Peng\|Yu, Shiying\|Yuan, Xianglin\|Zhu, Feng\|Wang, Yihua\|Xiong, Hua
PMID:	27806324

333.
Journal:	Cancer Chemother Pharmacol. 2016 Dec;78(6):1269-1281.
Title:	Enhanced anti-tumour activity of the combination of the novel MEK inhibitor WX-554 and the novel PI3K inhibitor WX-037.
Author:	Haagensen, Emma J\|Thomas, Huw D\|Schmalix, Wolfgang A\|Payne, Andrew C\|Kevorkian, Lara\|Allen, Rodger A\|Bevan, Paul\|Maxwell, Ross J\|Newell, David R
PMID:	27837257

334.
Journal:	Onco Targets Ther. 2016 Nov 30;9:7285-7295.
Title:	CTGF enhances resistance to 5-FU-mediating cell apoptosis through FAK/MEK/ERK signal pathway in colorectal cancer.
Author:	Yang, Kai\|Gao, Kai\|Hu, Gui\|Wen, Yanguang\|Lin, Changwei\|Li, Xiaorong
PMID:	27942222

335.
Journal:	Curr Oncol. 2016 Dec;23(6):e571-e575.
Title:	Personalized oncogenomics in the management of gastrointestinal carcinomas-early experiences from a pilot study.
Author:	Sheffield, B S\|Tessier-Cloutier, B\|Li-Chang, H\|Shen, Y\|Pleasance, E\|Kasaian, K\|Li, Y\|Jones, S J M\|Lim, H J\|Renouf, D J\|Huntsman, D G\|Yip, S\|Laskin, J\|Marra, M\|Schaeffer, D F
PMID:	28050146

336.
Journal:	Clin Cancer Res. 2017 Jan 1;23(1):104-115.
Title:	BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression.
Author:	Barras, David\|Missiaglia, Edoardo\|Wirapati, Pratyaksha\|Sieber, Oliver M\|Jorissen, Robert N\|Love, Chris\|Molloy, Peter L\|Jones, Ian T\|McLaughlin, Stephen\|Gibbs, Peter\|Guinney, Justin\|Simon, Iris M\|Roth, Arnaud D\|Bosman, Fred T\|Tejpar, Sabine\|Delorenzi, Maur
PMID:	27354468

337.
Journal:	Oncogene. 2017 Feb 9;36(6):787-796.
Title:	FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.
Author:	Tong, J\|Tan, S\|Zou, F\|Yu, J\|Zhang, L
PMID:	27399335

338.
Journal:	Invest New Drugs. 2017 Feb;35(1):47-58.
Title:	A phase I dose-escalation study of TAK-733, an investigational oral MEK inhibitor, in patients with advanced solid tumors.
Author:	Adjei, Alex A\|LoRusso, Patricia\|Ribas, Antoni\|Sosman, Jeffrey A\|Pavlick, Anna\|Dy, Grace K\|Zhou, Xiaofei\|Gangolli, Esha\|Kneissl, Michelle\|Faucette, Stephanie\|Neuwirth, Rachel\|Bozon, Viviana
PMID:	27650277

339.
Journal:	Gut. 2017 Jun;66(6):1106-1115.
Title:	Inhibition of RAF1 kinase activity restores apicobasal polarity and impairs tumour growth in human colorectal cancer.
Author:	Borovski, Tijana\|Vellinga, Thomas T\|Laoukili, Jamila\|Santo, Evan E\|Fatrai, Szabolcs\|van Schelven, Susanne\|Verheem, Andre\|Marvin, Dieuwke L\|Ubink, Inge\|Borel Rinkes, Inne H M\|Kranenburg, Onno
PMID:	27670374

340.
Journal:	Clin Cancer Res. 2017 Apr 15;23(8):2027-2037.
Title:	The MAPK Pathway Regulates Intrinsic Resistance to BET Inhibitors in Colorectal Cancer.
Author:	Ma, Yufang\|Wang, Lihong\|Neitzel, Leif R\|Loganathan, Sudan N\|Tang, Nan\|Qin, Lili\|Crispi, Emily E\|Guo, Yan\|Knapp, Stefan\|Beauchamp, R Daniel\|Lee, Ethan\|Wang, Jialiang
PMID:	27678457

341.
Journal:	Mol Cancer Ther. 2017 Feb;16(2):344-356.
Title:	Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities.
Author:	Talbert, Erin E\|Yang, Jennifer\|Mace, Thomas A\|Farren, Matthew R\|Farris, Alton B\|Young, Gregory S\|Elnaggar, Omar\|Che, Zheng\|Timmers, Cynthia D\|Rajasekera, Priyani\|Maskarinec, Jennifer M\|Bloomston, Mark\|Bekaii-Saab, Tanios\|Guttridge, Denis C\|Lesinski, Grego
PMID:	27811010

342.
Journal:	Oncotarget. 2017 Jan 17;8(3):5048-5056.
Title:	FOXD3 is a tumor suppressor of colon cancer by inhibiting EGFR-Ras-Raf-MEK-ERK signal pathway.
Author:	Li, Kun\|Guo, Qunfeng\|Yang, Jun\|Chen, Hui\|Hu, Kewen\|Zhao, Juan\|Zheng, Shunxin\|Pang, Xiufeng\|Zhou, Sufang\|Dang, Yongyan\|Li, Lei
PMID:	27926503

343.
Journal:	Oncotarget. 2017 Jan 17;8(3):5003-5015.
Title:	Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells.
Author:	Song, Qiaoling\|Sun, Xiaoxiao\|Guo, Hui\|Yu, Qiang
PMID:	28002807

344.
Journal:	Biochem J. 2017 Feb 20;474(5):647-665.
Title:	Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells.
Author:	Said, Anan H\|Hu, Shien\|Abutaleb, Ameer\|Watkins, Tonya\|Cheng, Kunrong\|Chahdi, Ahmed\|Kuppusamy, Panjamurthy\|Saxena, Neeraj\|Xie, Guofeng\|Raufman, Jean-Pierre
PMID:	28008134

345.
Journal:	Cancer Treat Rev. 2017 Feb;53:61-69.
Title:	Cancer resistance to therapies against the EGFR-RAS-RAF pathway: The role of MEK.
Author:	Martinelli, Erika\|Morgillo, Floriana\|Troiani, Teresa\|Ciardiello, Fortunato
PMID:	28073102

346.
Journal:	Cell. 2017 Feb 23;168(5):817-829.e15.
Title:	KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.
Author:	Burgess, Michael R\|Hwang, Eugene\|Mroue, Rana\|Bielski, Craig M\|Wandler, Anica M\|Huang, Benjamin J\|Firestone, Ari J\|Young, Amy\|Lacap, Jennifer A\|Crocker, Lisa\|Asthana, Saurabh\|Davis, Elizabeth M\|Xu, Jin\|Akagi, Keiko\|Le Beau, Michelle M\|Li, Qing\|Haley, Benja
PMID:	28215705

347.
Journal:	Cancer Sci. 2017 Jun;108(6):1135-1143.
Title:	BRAF mutations are associated with increased iron regulatory protein-2 expression in colorectal tumorigenesis.
Author:	Horniblow, Richard D\|Bedford, Matthew\|Hollingworth, Robert\|Evans, Sarah\|Sutton, Emily\|Lal, Neeraj\|Beggs, Andrew\|Iqbal, Tariq H\|Tselepis, Chris
PMID:	28281325

348.
Journal:	Int J Mol Sci. 2017 Mar 8;18(3). pii: ijms18030585.
Title:	Strategies for Overcoming Resistance in Tumours Harboring BRAF Mutations.
Author:	Obaid, Nourah Mohammad\|Bedard, Karen\|Huang, Weei-Yuarn
PMID:	28282860

349.
Journal:	PLoS One. 2017 Mar 16;12(3):e0174151.
Title:	In vivo and ex vivo cetuximab sensitivity assay using three-dimensional primary culture system to stratify KRAS mutant colorectal cancer.
Author:	Tashiro, Takahiro\|Okuyama, Hiroaki\|Endo, Hiroko\|Kawada, Kenji\|Ashida, Yasuko\|Ohue, Masayuki\|Sakai, Yoshiharu\|Inoue, Masahiro
PMID:	28301591

350.
Journal:	Cancer Lett. 2017 Jun 28;396:94-102.
Title:	Co-targeting of EGFR and autophagy signaling is an emerging treatment strategy in metastatic colorectal cancer.
Author:	Koustas, Evangelos\|Karamouzis, Michalis V\|Mihailidou, Chrysovalantou\|Schizas, Dimitrios\|Papavassiliou, Athanasios G
PMID:	28323034

351.
Journal:	Expert Opin Ther Pat. 2017 May;27(5):527-538.
Title:	Methods of selecting combination therapy for colorectal cancer patients: a patent evaluation of US20160025730A1.
Author:	Plano, Daniel\|Alcolea, Veronica\|Sanmartin, Carmen\|Sharma, Arun K
PMID:	28366103

352.
Journal:	Cancer Res. 2017 Jun 15;77(12):3364-3375.
Title:	Drug Resistance Mechanisms in Colorectal Cancer Dissected with Cell Type-Specific Dynamic Logic Models.
Author:	Eduati, Federica\|Doldan-Martelli, Victoria\|Klinger, Bertram\|Cokelaer, Thomas\|Sieber, Anja\|Kogera, Fiona\|Dorel, Mathurin\|Garnett, Mathew J\|Bluthgen, Nils\|Saez-Rodriguez, Julio
PMID:	28381545

353.
Journal:	Pharmacol Res. 2017 Jul;121:202-212.
Title:	ROS1 protein-tyrosine kinase inhibitors in the treatment of ROS1 fusion protein-driven non-small cell lung cancers.
Author:	Roskoski, Robert Jr
PMID:	28465216

354.
Journal:	Immunopharmacol Immunotoxicol. 2017 Aug;39(4):199-210.
Title:	The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation.
Author:	Blom, Kristin\|Senkowski, Wojciech\|Jarvius, Malin\|Berglund, Malin\|Rubin, Jenny\|Lenhammar, Lena\|Parrow, Vendela\|Andersson, Claes\|Loskog, Angelica\|Fryknas, Marten\|Nygren, Peter\|Larsson, Rolf
PMID:	28472897

355.
Journal:	EBioMedicine. 2017 Jun;20:50-60.
Title:	BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer.
Author:	Xue, Peipei\|Zeng, Fanfan\|Duan, Qiuhong\|Xiao, Juanjuan\|Liu, Lin\|Yuan, Ping\|Fan, Linni\|Sun, Huimin\|Malyarenko, Olesya S\|Lu, Hui\|Xiu, Ruijuan\|Liu, Shaoqing\|Shao, Chen\|Zhang, Jianmin\|Yan, Wei\|Wang, Zhe\|Zheng, Jianyong\|Zhu, Feng
PMID:	28501528

356.
Journal:	Oncotarget. 2017 Jul 11;8(28):45898-45917.
Title:	Molecular dissection of effector mechanisms of RAS-mediated resistance to anti-EGFR antibody therapy.
Author:	Kasper, Stefan\|Reis, Henning\|Ziegler, Sophie\|Nothdurft, Silke\|Mueller, Andre\|Goetz, Moritz\|Wiesweg, Marcel\|Phasue, Jeannette\|Ting, Saskia\|Wieczorek, Sarah\|Even, Anna\|Worm, Karl\|Pogorzelski, Michael\|Breitenbuecher, Sandra\|Meiler, Johannes\|Paul, Andreas\|Tra
PMID:	28507280

357.
Journal:	Biochem Biophys Res Commun. 2017 Jul 15;489(1):14-20.
Title:	AKT is critically involved in the antagonism of BRAF inhibitor sorafenib against dabrafenib in colorectal cancer cells harboring both wild-type and mutant (V600E) BRAF genes.
Author:	Wang, Hongbin\|Quan, Haitian\|Lou, Liguang
PMID:	28536078

358.
Journal:	Anticancer Res. 2017 Jun;37(6):2831-2838.
Title:	MEK162 Enhances Antitumor Activity of 5-Fluorouracil and Trifluridine in KRAS-mutated Human Colorectal Cancer Cell Lines.
Author:	Gong, Jun\|Chen, Yuan\|Yang, Lixin\|Pillai, Raju\|Shirasawa, Senji\|Fakih, Marwan
PMID:	28551618

359.
Journal:	Cancer Biother Radiopharm. 2017 Jun;32(5):149-160.
Title:	Molecular Targeted Drugs and Treatment of Colorectal Cancer: Recent Progress and Future Perspectives.
Author:	Geng, Fang\|Wang, Zheng\|Yin, Hang\|Yu, Junxian\|Cao, Bangwei
PMID:	28622036

360.
Journal:	PLoS One. 2017 Jun 22;12(6):e0179510.
Title:	Bilateral blockade of MEK- and PI3K-mediated pathways downstream of mutant KRAS as a treatment approach for peritoneal mucinous malignancies.
Author:	Kuracha, Murali R\|Thomas, Peter\|Loggie, Brian W\|Govindarajan, Venkatesh
PMID:	28640835

361.
Journal:	NPJ Syst Biol Appl. 2017 Jun 2;3:14.
Title:	Clinical responses to ERK inhibition in BRAF(V600E)-mutant colorectal cancer predicted using a computational model.
Author:	Kirouac, Daniel C\|Schaefer, Gabriele\|Chan, Jocelyn\|Merchant, Mark\|Orr, Christine\|Huang, Shih-Min A\|Moffat, John\|Liu, Lichuan\|Gadkar, Kapil\|Ramanujan, Saroja
PMID:	28649441

362.
Journal:	Mol Cancer Res. 2017 Oct;15(10):1431-1444.
Title:	BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity.
Author:	Emery, Caroline M\|Monaco, Kelli-Ann\|Wang, Ping\|Balak, Marissa\|Freeman, Alyson\|Meltzer, Jodi\|Delach, Scott M\|Rakiec, Daniel\|Ruddy, David A\|Korn, Joshua M\|Haling, Jacob\|Acker, Michael G\|Caponigro, Giordano
PMID:	28655712

363.
Journal:	Cell Rep. 2017 Jul 25;20(4):999-1015.
Title:	A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution.
Author:	Anderson, Grace R\|Winter, Peter S\|Lin, Kevin H\|Nussbaum, Daniel P\|Cakir, Merve\|Stein, Elizabeth M\|Soderquist, Ryan S\|Crawford, Lorin\|Leeds, Jim C\|Newcomb, Rachel\|Stepp, Priya\|Yip, Catherine\|Wardell, Suzanne E\|Tingley, Jennifer P\|Ali, Moiez\|Xu, Mengmeng\|Ry
PMID:	28746882

364.
Journal:	Oncogene. 2017 Nov 16;36(46):6480-6489.
Title:	Tumor microenvironment confers mTOR inhibitor resistance in invasive intestinal adenocarcinoma.
Author:	Fujishita, T\|Kojima, Y\|Kajino-Sakamoto, R\|Taketo, M M\|Aoki, M
PMID:	28759045

365.
Journal:	Mol Cancer Ther. 2017 Nov;16(11):2340-2350.
Title:	A Bifunctional MAPK/PI3K Antagonist for Inhibition of Tumor Growth and Metastasis.
Author:	Galban, Stefanie\|Apfelbaum, April A\|Espinoza, Carlos\|Heist, Kevin\|Haley, Henry\|Bedi, Karan\|Ljungman, Mats\|Galban, Craig J\|Luker, Gary D\|Dort, Marcian Van\|Ross, Brian D
PMID:	28775144

366.
Journal:	Oncogene. 2017 Nov 23;36(47):6581-6591.
Title:	Synergistic activity and heterogeneous acquired resistance of combined MDM2 and MEK inhibition in KRAS mutant cancers.
Author:	Hata, A N\|Rowley, S\|Archibald, H L\|Gomez-Caraballo, M\|Siddiqui, F M\|Ji, F\|Jung, J\|Light, M\|Lee, J S\|Debussche, L\|Sidhu, S\|Sadreyev, R I\|Watters, J\|Engelman, J A
PMID:	28783173

367.
Journal:	Cancer Lett. 2017 Dec 28;411:90-99.
Title:	SUMOylation of IQGAP1 promotes the development of colorectal cancer.
Author:	Liang, Ziwei\|Yang, Yanfang\|He, Yu\|Yang, Pengbo\|Wang, Xixi\|He, Gu\|Zhang, Peng\|Zhu, Hongxia\|Xu, Ningzhi\|Zhao, Xia\|Liang, Shufang
PMID:	28987385

368.
Journal:	Target Oncol. 2017 Dec;12(6):775-785.
Title:	A Multi-Arm Phase I Study of the PI3K/mTOR Inhibitors PF-04691502 and Gedatolisib (PF-05212384) plus Irinotecan or the MEK Inhibitor PD-0325901 in Advanced Cancer.
Author:	Wainberg, Zev A\|Alsina, Maria\|Soares, Heloisa P\|Brana, Irene\|Britten, Carolyn D\|Del Conte, Gianluca\|Ezeh, Patrick\|Houk, Brett\|Kern, Kenneth A\|Leong, Stephen\|Pathan, Nuzhat\|Pierce, Kristen J\|Siu, Lillian L\|Vermette, Jennifer\|Tabernero, Josep
PMID:	29067643

369.
Journal:	Oncotarget. 2017 Aug 29;8(44):76574-76586.
Title:	Functional consequence of the p53 codon 72 polymorphism in colorectal cancer.
Author:	Katkoori, Venkat R\|Manne, Upender\|Chaturvedi, Lakshmi S\|Basson, Marc D\|Haan, Pam\|Coffey, Daniel\|Bumpers, Harvey L
PMID:	29100333

370.
Journal:	Cancer Cell Int. 2017 Oct 28;17:91.
Title:	miR-422a inhibits cell proliferation in colorectal cancer by targeting AKT1 and MAPK1.
Author:	Wei, Wen-Ting\|Nian, Xin-Xin\|Wang, Shu-Yang\|Jiao, Hong-Li\|Wang, Yong-Xia\|Xiao, Zhi-Yuan\|Yang, Run-Wei\|Ding, Yan-Qing\|Ye, Ya-Ping\|Liao, Wen-Ting
PMID:	29118671

371.
Journal:	Oncotarget. 2016 Aug 19;8(65):108463-108479.
Title:	Dual targeting of HER3 and MEK may overcome HER3-dependent drug-resistance of colon cancers.
Author:	Bon, Giulia\|Loria, Rossella\|Amoreo, Carla Azzurra\|Verdina, Alessandra\|Sperduti, Isabella\|Mastrofrancesco, Arianna\|Soddu, Silvia\|Diodoro, Maria Grazia\|Mottolese, Marcella\|Todaro, Matilde\|Stassi, Giorgio\|Milella, Michele\|De Maria, Ruggero\|Falcioni, Rita
PMID:	29312543

372.
Journal:	Oncotarget. 2017 Dec 5;8(67):111943-111965.
Title:	Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells.
Author:	Diaz-Valdivia, Natalia I\|Calderon, Claudia C\|Diaz, Jorge E\|Lobos-Gonzalez, Lorena\|Sepulveda, Hugo\|Ortiz, Rina J\|Martinez, Samuel\|Silva, Veronica\|Maldonado, Horacio J\|Silva, Patricio\|Wehinger, Sergio\|Burzio, Veronica A\|Torres, Vicente A\|Montecino, Martin\|L
PMID:	29340103

373.
Journal:	Oncotarget. 2017 Dec 9;8(70):114663-114676.
Title:	EGFR expression in patients with stage III colorectal cancer after adjuvant chemotherapy and on cancer cell function.
Author:	Huang, Ching-Wen\|Chen, Yi-Ting\|Tsai, Hsiang-Lin\|Yeh, Yung-Sung\|Su, Wei-Chih\|Ma, Cheng-Jen\|Tsai, Tsen-Ni\|Wang, Jaw-Yuan
PMID:	29383110

374.
Journal:	Tumori. 2018 Jan-Feb;104(1):43-50.
Title:	Long noncoding RNA CCAT1 promotes cell proliferation and metastasis in human medulloblastoma via MAPK pathway.
Author:	Gao, Ran\|Zhang, Rui\|Zhang, Cuicui\|Zhao, Li\|Zhang, Yue
PMID:	28777430

375.
Journal:	Autophagy. 2018;14(1):134-151.
Title:	Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells.
Author:	Yoo, Byong Hoon\|Khan, Iman Aftab\|Koomson, Ananda\|Gowda, Pramod\|Sasazuki, Takehiko\|Shirasawa, Senji\|Gujar, Shashi\|Rosen, Kirill V.
PMID:	28933585

376.
Journal:	Anticancer Agents Med Chem. 2018;18(4):583-590.
Title:	Oleanolic Acid Inhibits Colorectal Cancer Angiogenesis by Blocking the VEGFR2 Signaling Pathway.
Author:	Niu, Guoping\|Sun, Li\|Pei, Yunfeng\|Wang, Duping
PMID:	29065844

377.
Journal:	J Cell Biochem. 2018 Mar;119(3):2864-2874.
Title:	HOXA3 promotes tumor growth of human colon cancer through activating EGFR/Ras/Raf/MEK/ERK signaling pathway.
Author:	Zhang, Xianxiang\|Liu, Guangwei\|Ding, Lei\|Jiang, Tao\|Shao, Shihong\|Gao, Yuan\|Lu, Yun
PMID:	29073728

378.
Journal:	JAMA Oncol. 2018 Apr 1;4(4):564-568.
Title:	Association of Tumor HER3 Messenger RNA Expression With Panitumumab Efficacy in Advanced Colorectal Cancer.
Author:	Seligmann, Jenny F\|Hatch, Ace J\|Richman, Susan D\|Elliott, Faye\|Jacobs, Bart\|Brown, Sarah\|Hurwitz, Herbert\|Barrett, Jennifer H\|Quirke, Philip\|Nixon, Andrew B\|Seymour, Matthew T
PMID:	29075780

379.
Journal:	Mol Oncol. 2018 Feb;12(2):224-238.
Title:	MAPK inhibitors induce serine peptidase inhibitor Kazal type 1 (SPINK1) secretion in BRAF V600E-mutant colorectal adenocarcinoma.
Author:	Rasanen, Kati\|Dang, Kien X\|Mustonen, Harri\|Ho, Tho H\|Lintula, Susanna\|Koistinen, Hannu\|Stenman, Ulf-Hakan\|Haglund, Caj\|Stenman, Jakob
PMID:	29193645

380.
Journal:	Mol Cancer Res. 2018 Mar;16(3):543-553.
Title:	TANKYRASE Inhibition Enhances the Antiproliferative Effect of PI3K and EGFR Inhibition, Mutually Affecting beta-CATENIN and AKT Signaling in Colorectal Cancer.
Author:	Solberg, Nina T\|Waaler, Jo\|Lund, Kaja\|Mygland, Line\|Olsen, Petter A\|Krauss, Stefan
PMID:	29222171

381.
Journal:	Mol Cancer Res. 2018 Mar;16(3):378-389.
Title:	Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer.
Author:	Zhang, Peng\|Kawakami, Hisato\|Liu, Weizhen\|Zeng, Xiangyu\|Strebhardt, Klaus\|Tao, Kaixiong\|Huang, Shengbing\|Sinicrope, Frank A
PMID:	29233910

382.
Journal:	Mol Cancer Ther. 2018 Feb;17(2):544-553.
Title:	beta-Catenin mRNA Silencing and MEK Inhibition Display Synergistic Efficacy in Preclinical Tumor Models.
Author:	Ganesh, Shanthi\|Shui, Xue\|Craig, Kevin P\|Koser, Martin L\|Chopda, Girish R\|Cyr, Wendy A\|Lai, Chengjung\|Dudek, Henryk\|Wang, Weimin\|Brown, Bob D\|Abrams, Marc T
PMID:	29282298

383.
Journal:	Mol Cancer Ther. 2018 Jan;17(1):3-16.
Title:	Rational Approaches for Combination Therapy Strategies Targeting the MAP Kinase Pathway in Solid Tumors.
Author:	Tolcher, Anthony W\|Peng, Wei\|Calvo, Emiliano
PMID:	29295962

384.
Journal:	Genome Med. 2018 Jan 4;10(1):2.
Title:	Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells.
Author:	Kundu, Snehangshu\|Ali, Muhammad Akhtar\|Handin, Niklas\|Padhan, Narendra\|Larsson, Jimmy\|Karoutsou, Maria\|Ban, Kenneth\|Wisniewski, Jacek R\|Artursson, Per\|He, Liqun\|Hellstrom, Mats\|Sjoblom, Tobias
PMID:	29301589

385.
Journal:	Oncogene. 2018 Mar;37(12):1576-1593.
Title:	BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines.
Author:	Herr, Ricarda\|Halbach, Sebastian\|Heizmann, Miriam\|Busch, Hauke\|Boerries, Melanie\|Brummer, Tilman
PMID:	29326440

386.
Journal:	Oncol Rep. 2018 Mar;39(3):1516-1522.
Title:	Fucoidan downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells.
Author:	Kim, In-Hye\|Nam, Taek-Jeong
PMID:	29328495

387.
Journal:	Cancer Discov. 2018 Apr;8(4):417-427.
Title:	Convergent Therapeutic Strategies to Overcome the Heterogeneity of Acquired Resistance in BRAF(V600E) Colorectal Cancer.
Author:	Hazar-Rethinam, Mehlika\|Kleyman, Marianna\|Han, G Celine\|Liu, David\|Ahronian, Leanne G\|Shahzade, Heather A\|Chen, Lifeng\|Parikh, Aparna R\|Allen, Jill N\|Clark, Jeffrey W\|Kwak, Eunice L\|Faris, Jason E\|Murphy, Janet E\|Hong, Theodore S\|Van Seventer, Emily E\|Nad
PMID:	29431697

388.
Journal:	Cancer Discov. 2018 Apr;8(4):428-443.
Title:	Combined BRAF, EGFR, and MEK Inhibition in Patients with BRAF(V600E)-Mutant Colorectal Cancer.
Author:	Corcoran, Ryan B\|Andre, Thierry\|Atreya, Chloe E\|Schellens, Jan H M\|Yoshino, Takayuki\|Bendell, Johanna C\|Hollebecque, Antoine\|McRee, Autumn J\|Siena, Salvatore\|Middleton, Gary\|Muro, Kei\|Gordon, Michael S\|Tabernero, Josep\|Yaeger, Rona\|O'Dwyer, Peter J\|Humble
PMID:	29431699

389.
Journal:	Cell Death Dis. 2018 Feb 13;9(2):217.
Title:	Baicalin induces cellular senescence in human colon cancer cells via upregulation of DEPP and the activation of Ras/Raf/MEK/ERK signaling.
Author:	Wang, Zhou\|Ma, Lingman\|Su, Mengqi\|Zhou, Yiran\|Mao, Ke\|Li, Chengqin\|Peng, Guangyong\|Zhou, Changlin\|Shen, Baiyong\|Dou, Jie
PMID:	29440765

390.
Journal:	Expert Opin Biol Ther. 2018 May;18(5):561-573.
Title:	Results and challenges of immune checkpoint inhibitors in colorectal cancer.
Author:	Emambux, Sheik\|Tachon, Gaelle\|Junca, Audelaure\|Tougeron, David
PMID:	29471676

391.
Journal:	Expert Opin Biol Ther. 2018 Apr;18(4):449-457.
Title:	Atezolizumab for the treatment of colorectal cancer: the latest evidence and clinical potential.
Author:	Tapia Rico, Gonzalo\|Price, Timothy J
PMID:	29471699

392.
Journal:	Cancer Sci. 2018 May;109(5):1455-1467.
Title:	Impairment of K-Ras signaling networks and increased efficacy of epidermal growth factor receptor inhibitors by a novel synthetic miR-143.
Author:	Akao, Yukihiro\|Kumazaki, Minami\|Shinohara, Haruka\|Sugito, Nobuhiko\|Kuranaga, Yuki\|Tsujino, Takuya\|Yoshikawa, Yuki\|Kitade, Yukio
PMID:	29498789

393.
Journal:	Oncogene. 2018 Jun;37(25):3440-3455.
Title:	Mutant KRAS promotes liver metastasis of colorectal cancer, in part, by upregulating the MEK-Sp1-DNMT1-miR-137-YB-1-IGF-IR signaling pathway.
Author:	Chu, Po-Chen\|Lin, Peng-Chan\|Wu, Hsing-Yu\|Lin, Kuen-Tyng\|Wu, Christina\|Bekaii-Saab, Tanios\|Lin, Yih-Jyh\|Lee, Chung-Ta\|Lee, Jeng-Chang\|Chen, Ching-Shih
PMID:	29559746

394.
Journal:	Oncotarget. 2018 Feb 16;9(18):14306-14310.
Title:	TP53 mutations and number of alterations correlate with maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) [(18)F] fluorodeoxyglucose ((18)F-FDG PET).
Author:	Chang, Geraldine H\|Kurzrock, Razelle\|Tran, Lisa\|Schwaederle, Maria\|Hoh, Carl K
PMID:	29581845

395.
Journal:	Methods Mol Biol. 2018;1765:281-297.
Title:	Molecular Testing for the Treatment of Advanced Colorectal Cancer: An Overview.
Author:	Lin, Patrick S\|Semrad, Thomas J
PMID:	29589315

396.
Journal:	Cancer Discov. 2018 Apr;8(4):389-391.
Title:	Advances on the BRAF Front in Colorectal Cancer.
Author:	Janku, Filip
PMID:	29610287

397.
Journal:	Gastrointest Cancer. 2018;8:13-23.
Title:	Emerging treatment options for BRAF-mutant colorectal cancer.
Author:	Ursem, Carling\|Atreya, Chloe E\|Van Loon, Katherine
PMID:	29628780

398.
Journal:	Oncogene. 2018 Jul;37(28):3790-3805.
Title:	Collagen IV-conveyed signals can regulate chemokine production and promote liver metastasis.
Author:	Vaniotis, George\|Rayes, Roni F\|Qi, Shu\|Milette, Simon\|Wang, Ni\|Perrino, Stephanie\|Bourdeau, France\|Nystrom, Hanna\|He, Yi\|Lamarche-Vane, Nathalie\|Brodt, Pnina
PMID:	29651051

399.
Journal:	Expert Rev Mol Diagn. 2018 Jun;18(6):499-512.
Title:	BRAF-mutant colorectal cancer, a different breed evolving.
Author:	Lai, Eleonora\|Pretta, Andrea\|Impera, Valentino\|Mariani, Stefano\|Giampieri, Riccardo\|Casula, Laura\|Pusceddu, Valeria\|Coni, Pierpaolo\|Fanni, Daniela\|Puzzoni, Marco\|Demurtas, Laura\|Ziranu, Pina\|Faa, Gavino\|Scartozzi, Mario
PMID:	29708446

400.
Journal:	Cell Calcium. 2018 Jun;72:70-80.
Title:	Oncogenic KRAS suppresses store-operated Ca(2+) entry and ICRAC through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines.
Author:	Pierro, Cristina\|Zhang, Xuexin\|Kankeu, Cynthia\|Trebak, Mohamed\|Bootman, Martin D\|Roderick, H Llewelyn
PMID:	29748135

401.
Journal:	Cell Physiol Biochem. 2018;47(2):680-693.
Title:	Efficacy of the MEK Inhibitor Cobimetinib and its Potential Application to Colorectal Cancer Cells.
Author:	Gong, Shu\|Xu, Dongsheng\|Zhu, Jialin\|Zou, Fangdong\|Peng, Rui
PMID:	29794421

402.
Journal:	Nat Med. 2018 Jul;24(7):961-967.
Title:	SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo.
Author:	Mainardi, Sara\|Mulero-Sanchez, Antonio\|Prahallad, Anirudh\|Germano, Giovanni\|Bosma, Astrid\|Krimpenfort, Paul\|Lieftink, Cor\|Steinberg, Jeffrey D\|de Wit, Niels\|Goncalves-Ribeiro, Samuel\|Nadal, Ernest\|Bardelli, Alberto\|Villanueva, Alberto\|Bernards, Rene
PMID:	29808006

403.
Journal:	Mol Carcinog. 2018 Oct;57(10):1300-1310.
Title:	AKR1B10 activates diacylglycerol (DAG) second messenger in breast cancer cells.
Author:	Huang, Chenfei\|Cao, Zhe\|Ma, Jun\|Shen, Yi\|Bu, Yiwen\|Khoshaba, Ramina\|Shi, Guiyuan\|Huang, Dan\|Liao, Duan-Fang\|Ji, Haitao\|Jin, Junfei\|Cao, Deliang
PMID:	29846015

404.
Journal:	Case Rep Surg. 2018 Apr 15;2018:8782328.
Title:	BRAF Inhibitors for BRAF V600E Mutant Colorectal Cancers: Literature Survey and Case Report.
Author:	Peker, Yasar Subutay\|Can, Mehmet Fatih\|Ozerhan, Ismail Hakki\|Yagci, Gokhan\|Zeybek, Nazif\|Kavakli, Kutan\|Gurkok, Sedat\|Gozubuyuk, Alper\|Genc, Onur\|Erdem, Gokhan\|Ozet, Ahmet\|Gerek, Mustafa\|Peker, Yusuf
PMID:	29850361

405.
Journal:	Int J Mol Sci. 2018 May 31;19(6). pii: ijms19061625.
Title:	NSC 95397 Suppresses Proliferation and Induces Apoptosis in Colon Cancer Cells through MKP-1 and the ERK1/2 Pathway.
Author:	Dubey, Navneet Kumar\|Peng, Bou-Yue\|Lin, Chien-Min\|Wang, Peter D\|Wang, Joseph R\|Chan, Chun-Hao\|Wei, Hong-Jian\|Deng, Win-Ping
PMID:	29857489

406.
Journal:	Mol Oncol. 2018 Aug;12(8):1398-1409.
Title:	Macrophage migration inhibitory factor promotes resistance to MEK blockade in KRAS mutant colorectal cancer cells.
Author:	Cheon, Seul-Ki\|Kim, Hwang-Phill\|Park, Ye-Lim\|Jang, Jee-Eun\|Lim, Yoojoo\|Song, Sang-Hyun\|Han, Sae-Won\|Kim, Tae-You
PMID:	29896883

407.
Journal:	Oncol Lett. 2018 Jul;16(1):326-334.
Title:	Cetuximab improves AZD6244 antitumor activity in colorectal cancer HT29 cells in vitro and in nude mice by attenuating HER3/Akt pathway activation.
Author:	Zhang, Qin\|Xiao, He\|Jin, Feng\|Li, Mengxia\|Luo, Jia\|Wang, Ge
PMID:	29928418

408.
Journal:	Cancer Res. 2018 Sep 1;78(17):4839-4852.
Title:	Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer.
Author:	Stevens, Payton D\|Wen, Yang-An\|Xiong, Xiaopeng\|Zaytseva, Yekaterina Y\|Li, Austin T\|Wang, Chi\|Stevens, Ashley T\|Farmer, Trevor N\|Gan, Tong\|Weiss, Heidi L\|Inagaki, Masaki\|Marchetto, Sylvie\|Borg, Jean-Paul\|Gao, Tianyan
PMID:	29980571

409.
Journal:	Cancer Lett. 2018 Oct 1;433:165-175.
Title:	Extracellular domain of EpCAM enhances tumor progression through EGFR signaling in colon cancer cells.
Author:	Liang, Kang-Hao\|Tso, Hsien-Cheng\|Hung, Shao-Hsi\|Kuan, I-I\|Lai, Jun-Kai\|Ke, Feng-Yi\|Chuang, Yi-Ting\|Liu, I-Ju\|Wang, Yi-Ping\|Chen, Ruey-Hwa\|Wu, Han-Chung
PMID:	29981429

410.
Journal:	Dev Reprod. 2018 Jun;22(2):133-142.
Title:	Combination of BEZ235 and Metformin Has Synergistic Effect on Cell Viability in Colorectal Cancer Cells.
Author:	Kim, Taewan\|Kim, Taehyung\|Choi, Soonyoung\|Ko, Hyeran\|Park, Deokbae\|Lee, Youngki
PMID:	30023463

411.
Journal:	PLoS One. 2018 Aug 17;13(8):e0200836.
Title:	Molecular subtypes of colorectal cancer in pre-clinical models show differential response to targeted therapies: Treatment implications beyond KRAS mutations.
Author:	Pal, Rekha\|Wei, Ning\|Song, Nan\|Wu, Shaoyu\|Kim, Rim S\|Wang, Ying\|Gavin, Patrick G\|Lucas, Peter C\|Srinivasan, Ashok\|Allegra, Carmen J\|Jacobs, Samuel A\|Paik, Soonmyung\|Schmitz, John C\|Pogue-Geile, Katherine L
PMID:	30118499

412.
Journal:	J Natl Compr Canc Netw. 2018 Sep;16(9):1035-1040.
Title:	Targeting BRAF Mutations in High-Grade Neuroendocrine Carcinoma of the Colon.
Author:	Burkart, Jarred\|Owen, Dwight\|Shah, Manisha H\|Abdel-Misih, Sherif R Z\|Roychowdhury, Sameek\|Wesolowski, Robert\|Haraldsdottir, Sigurdis\|Reeser, Julie W\|Samorodnitsky, Eric\|Smith, Amy\|Konda, Bhavana
PMID:	30181415

413.
Journal:	Biomed Pharmacother. 2018 Sep 12;108:119-129.
Title:	FABP7 promotes cell proliferation and survival in colon cancer through MEK/ERK signaling pathway.
Author:	Ma, Ran\|Wang, Lan\|Yuan, Fang\|Wang, Shaoxuan\|Liu, Yingping\|Fan, Tingting\|Wang, Fulai
PMID:	30218856

414.
Journal:	Pathologe. 2018 Sep 18. pii: 10.1007/s00292-018-0495-x.
Title:	[Regulator proteins of actin dynamics as possible targets of antineoplastic therapies].
Author:	Steinestel, K
PMID:	30229281

415.
Journal:	J Exp Clin Cancer Res. 2018 Sep 19;37(1):231.
Title:	HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways.
Author:	Li, Qing\|Wang, Cong\|Wang, Yufeng\|Sun, Liankang\|Liu, Zhikui\|Wang, Liang\|Song, Tao\|Yao, Yingmin\|Liu, Qingguang\|Tu, Kangsheng
PMID:	30231922

416.
Journal:	Oncogene. 2018 Oct 22. pii: 10.1038/s41388-018-0547-y.
Title:	Targeting colon cancer with the novel STAT3 inhibitor bruceantinol.
Author:	Wei, Ning\|Li, Jun\|Fang, Cheng\|Chang, Jin\|Xirou, Vasiliki\|Syrigos, Nick K\|Marks, Benjamin J\|Chu, Edward\|Schmitz, John C
PMID:	30348989

417.
Journal:	Oncogene. 2018 Oct 23. pii: 10.1038/s41388-018-0554-z.
Title:	Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer.
Author:	Wagner, Steve\|Vlachogiannis, Georgios\|De Haven Brandon, Alexis\|Valenti, Melanie\|Box, Gary\|Jenkins, Liam\|Mancusi, Caterina\|Self, Annette\|Manodoro, Floriana\|Assiotis, Ioannis\|Robinson, Penny\|Chauhan, Ritika\|Rust, Alistair G\|Matthews, Nik\|Eason, Kate\|Khan, K
PMID:	30353166