Primary Site >> Biliary tract Cancer
Gene >> MAP2K7
| 1. | |||||||||||
| Journal: | Hepatology. 1997 Aug;26(2):288-94. | ||||||||||
| Title: | Hepatocytic phenotypes induced in sarcomatous cholangiocarcinoma cells treated with 5-azacytidine. | ||||||||||
| Author: | Enjoji, M|Nakashima, M|Honda, M|Sakai, H|Nawata, H | ||||||||||
| PMID: | 9252136 | ||||||||||
| 2. | |||||||||||
| Journal: | Gut. 2003 May;52(5):706-12. | ||||||||||
| Title: | Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma. | ||||||||||
| Author: | Tannapfel, A|Sommerer, F|Benicke, M|Katalinic, A|Uhlmann, D|Witzigmann, H|Hauss, J|Wittekind, C | ||||||||||
| PMID: | 12692057 | ||||||||||
| 3. | |||||||||||
| Journal: | Hepatology. 2003 May;37(5):1122-9. | ||||||||||
| Title: | Human WISP1v, a member of the CCN family, is associated with invasive cholangiocarcinoma. | ||||||||||
| Author: | Tanaka, Shinji|Sugimachi, Keishi|Kameyama, Toshifumi|Maehara, Shin-Ichiro|Shirabe, Ken|Shimada, Mitsuo|Wands, Jack R|Maehara, Yoshihiko | ||||||||||
| PMID: | 12717393 | ||||||||||
| 4. | |||||||||||
| Journal: | J Exp Clin Cancer Res. 2004 Dec;23(4):599-606. | ||||||||||
| Title: | A MEK inhibitor (U0126) markedly inhibits direct liver invasion of orthotopically inoculated human gallbladder cancer cells in nude mice. | ||||||||||
| Author: | Horiuchi, H|Kawamata, H|Furihata, T|Omotehara, F|Hori, H|Shinagawa, Y|Ohkura, Y|Tachibana, M|Yamazaki, T|Ajiki, T|Kuroda, Y|Fujimori, T | ||||||||||
| PMID: | 15743030 | ||||||||||
| 5. | |||||||||||
| Journal: | J Surg Res. 2006 Nov;136(1):78-84. Epub 2006 Sep 1. | ||||||||||
| Title: | Involvement of c-Met/hepatocyte growth factor pathway in cholangiocarcinoma cell invasion and its therapeutic inhibition with small interfering RNA specific for c-Met. | ||||||||||
| Author: | Leelawat, Kawin|Leelawat, Surang|Tepaksorn, Panada|Rattanasinganchan, Panthip|Leungchaweng, Anicha|Tohtong, Rutaiwan|Sobhon, Prasert | ||||||||||
| PMID: | 16950403 | ||||||||||
| 6. | |||||||||||
| Journal: | J Cancer Res Clin Oncol. 2007 Apr;133(4):271-8. Epub 2006 Nov 25. | ||||||||||
| Title: | Dual blockade of the Hedgehog and ERK1/2 pathways coordinately decreases proliferation and survival of cholangiocarcinoma cells. | ||||||||||
| Author: | Jinawath, Artit|Akiyama, Yoshimitsu|Sripa, Banchob|Yuasa, Yasuhito | ||||||||||
| PMID: | 17294242 | ||||||||||
| 7. | |||||||||||
| Journal: | Oncol Rep. 2008 Oct;20(4):863-72. | ||||||||||
| Title: | The growth inhibition of hepatocellular and cholangiocellular carcinoma cells by gemcitabine and the roles of extracellular signal-regulated and checkpoint kinases. | ||||||||||
| Author: | Matsumoto, Kazuya|Nagahara, Takakazu|Okano, Jun-Ichi|Murawaki, Yoshikazu | ||||||||||
| PMID: | 18813828 | ||||||||||
| 8. | |||||||||||
| Journal: | Ann Oncol. 2010 Oct;21 Suppl 7:vii345-8. | ||||||||||
| Title: | Advances in the treatment of metastatic or unresectable biliary tract cancer. | ||||||||||
| Author: | Valle, J W | ||||||||||
| PMID: | 20943640 | ||||||||||
| 9. | |||||||||||
| Journal: | Hepatogastroenterology. 2010 May-Jun;57(99-100):426-9. | ||||||||||
| Title: | Effective treatment of advanced cholangiocarcinoma by hepatic arterial infusion chemotherapy combination with sorafenib: one case report from China. | ||||||||||
| Author: | Qun, Wang|Tao, Yin | ||||||||||
| PMID: | 20698202 | ||||||||||
| 10. | |||||||||||
| Journal: | Curr Drug Targets. 2010 Jul;11(7):834-50. | ||||||||||
| Title: | Molecular targeted therapy of biliary tract cancer--results of the first clinical studies. | ||||||||||
| Author: | Wiedmann, Marcus W|Mossner, Joachim | ||||||||||
| PMID: | 20388063 | ||||||||||
| 11. | |||||||||||
| Journal: | Biochem Biophys Res Commun. 2011 Feb 18;405(3):333-7. | ||||||||||
| Title: | Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2. | ||||||||||
| Author: | Yoon, Hyunho|Min, Jeong-Ki|Lee, Jung Whoi|Kim, Dae-Ghon|Hong, Hyo Jeong | ||||||||||
| PMID: | 21130731 | ||||||||||
| 12. | |||||||||||
| Journal: | J Gastroenterol. 2011 Jun;46(6):779-89. | ||||||||||
| Title: | Potent in vitro and in vivo antitumor activity of sorafenib against human intrahepatic cholangiocarcinoma cells. | ||||||||||
| Author: | Sugiyama, Hiroaki|Onuki, Kenichiro|Ishige, Kazunori|Baba, Nobue|Ueda, Tetsuya|Matsuda, Sachiko|Takeuchi, Kaoru|Onodera, Masafumi|Nakanuma, Yasuni|Yamato, Masayuki|Yamamoto, Masakazu|Hyodo, Ichinosuke|Shoda, Junichi | ||||||||||
| PMID: | 21331764 | ||||||||||
| 13. | |||||||||||
| Journal: | Br J Cancer. 2012 May 8;106(10):1583-6. | ||||||||||
| Title: | Skeletal muscle anabolism is a side effect of therapy with the MEK inhibitor: selumetinib in patients with cholangiocarcinoma. | ||||||||||
| Author: | Prado, C M M|Bekaii-Saab, T|Doyle, L A|Shrestha, S|Ghosh, S|Baracos, V E|Sawyer, M B | ||||||||||
| PMID: | 22510747 | ||||||||||
| 14. | |||||||||||
| Journal: | Clin Cancer Res. 2013 Jan 1;19(1):118-27. | ||||||||||
| Title: | Sequence dependence of MEK inhibitor AZD6244 combined with gemcitabine for the treatment of biliary cancer. | ||||||||||
| Author: | Xu, Junyao|Knox, Jennifer J|Ibrahimov, Emin|Chen, Eric|Serra, Stefano|Tsao, Ming|Cao, Pinjiang|Vines, Douglass|Green, David E|Metran-Nascente, Cristiane|McNamara, Mairead G|Hedley, David W | ||||||||||
| PMID: | 23091117 | ||||||||||
| 15. | |||||||||||
| Journal: | Int J Oncol. 2013 Feb;42(2):690-8. | ||||||||||
| Title: | Genetic and epigenetic alterations are involved in the regulation of TPM1 in cholangiocarcinoma. | ||||||||||
| Author: | Yang, Wei|Wang, Xiaoyuan|Zheng, Wei|Li, Kedong|Liu, Haofeng|Sun, Yueming | ||||||||||
| PMID: | 23254774 | ||||||||||
| 16. | |||||||||||
| Journal: | Hepatology. 2013 Jun;57(6):2248-60. | ||||||||||
| Title: | Activation of mammalian target of rapamycin complex 1 (mTORC1) and Raf/Pyk2 by growth factor-mediated Eph receptor 2 (EphA2) is required for cholangiocarcinoma growth and metastasis. | ||||||||||
| Author: | Cui, Xiang-Dan|Lee, Mi-Jin|Kim, Jong-Hyun|Hao, Pei-Pei|Liu, Lan|Yu, Goung-Ran|Kim, Dae-Ghon | ||||||||||
| PMID: | 23315987 | ||||||||||
| 17. | |||||||||||
| Journal: | Oncotarget. 2013 Jan;4(1):156-65. | ||||||||||
| Title: | Targeted therapy of advanced gallbladder cancer and cholangiocarcinoma with aggressive biology: eliciting early response signals from phase 1 trials. | ||||||||||
| Author: | Subbiah, Ishwaria M|Subbiah, Vivek|Tsimberidou, Apostolia M|Naing, Aung|Kaseb, Ahmed O|Javle, Milind|Fu, Siqing|Hong, David S|Piha-Paul, Sarina|Wheler, Jennifer J|Hess, Kenneth R|Janku, Filip|Falchook, Gerald S|Wolff, Robert A|Kurzrock, Razelle | ||||||||||
| PMID: | 23391555 | ||||||||||
| 18. | |||||||||||
| Journal: | Am Soc Clin Oncol Educ Book. 2014:e165-70. | ||||||||||
| Title: | A review of recent data in the treatment of gallbladder cancer: what we know, what we do, and what should be done. | ||||||||||
| Author: | Muller, Bettina G|De Aretxabala, Xabier|Gonzalez Domingo, Manuel | ||||||||||
| PMID: | 24857099 | ||||||||||
| 19. | |||||||||||
| Journal: | Ecancermedicalscience. 2014 Nov 6;8:479. | ||||||||||
| Title: | Dramatic response to dabrafenib and trametinib combination in a BRAF V600E-mutated cholangiocarcinoma: implementation of a molecular tumour board and next-generation sequencing for personalized medicine. | ||||||||||
| Author: | Loaiza-Bonilla, Arturo|Clayton, Erica|Furth, Emma|O'Hara, Mark|Morrissette, Jennifer | ||||||||||
| PMID: | 25435907 | ||||||||||
| 20. | |||||||||||
| Journal: | Invest New Drugs. 2014 Dec;32(6):1144-54. | ||||||||||
| Title: | Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors. | ||||||||||
| Author: | Ewald, Florian|Norz, Dominik|Grottke, Astrid|Hofmann, Bianca T|Nashan, Bjorn|Jucker, Manfred | ||||||||||
| PMID: | 25152244 | ||||||||||
| 21. | |||||||||||
| Journal: | Best Pract Res Clin Gastroenterol. 2015 Apr;29(2):345-53. | ||||||||||
| Title: | Systemic therapy of cholangiocarcinoma: From chemotherapy to targeted therapies. | ||||||||||
| Author: | Schweitzer, N|Vogel, A | ||||||||||
| PMID: | 25966433 | ||||||||||
| 22. | |||||||||||
| Journal: | J Gastroenterol. 2016 Jul;51(7):711-21. | ||||||||||
| Title: | A potent therapeutics for gallbladder cancer by combinatorial inhibition of the MAPK and mTOR signaling networks. | ||||||||||
| Author: | Mohri, Dai|Ijichi, Hideaki|Miyabayashi, Koji|Takahashi, Ryota|Kudo, Yotaro|Sasaki, Takashi|Asaoka, Yoshinari|Tanaka, Yasuo|Ikenoue, Tsuneo|Tateishi, Keisuke|Tada, Minoru|Isayama, Hiroyuki|Koike, Kazuhiko | ||||||||||
| PMID: | 26614007 | ||||||||||
| 23. | |||||||||||
| Journal: | Oncotarget. 2016 Feb 2;7(5):5306-12. | ||||||||||
| Title: | Whole-exome tumor sequencing study in biliary cancer patients with a response to MEK inhibitors. | ||||||||||
| Author: | Ahn, Daniel H|Ozer, Hatice Gulcin|Hancioglu, Baris|Lesinski, Gregory B|Timmers, Cynthia|Bekaii-Saab, Tanios | ||||||||||
| PMID: | 26683364 | ||||||||||
| 24. | |||||||||||
| Journal: | J Exp Clin Cancer Res. 2016 Apr 16;35:68. | ||||||||||
| Title: | Prohibitin overexpression predicts poor prognosis and promotes cell proliferation and invasion through ERK pathway activation in gallbladder cancer. | ||||||||||
| Author: | Cao, Yang|Liang, Haibin|Zhang, Fei|Luan, Zhou|Zhao, Shuai|Wang, Xu-An|Liu, Shibo|Bao, Runfa|Shu, Yijun|Ma, Qiang|Zhu, Jian|Liu, Yingbin | ||||||||||
| PMID: | 27084680 | ||||||||||
| 25. | |||||||||||
| Journal: | J Gastrointest Oncol. 2016 Dec;7(6):E98-E102. | ||||||||||
| Title: | Impressive response to dual BRAF and MEK inhibition in patients with BRAF mutant intrahepatic cholangiocarcinoma-2 case reports and a brief review. | ||||||||||
| Author: | Lavingia, Viraj|Fakih, Marwan | ||||||||||
| PMID: | 28078132 | ||||||||||
| 26. | |||||||||||
| Journal: | Mol Cancer Ther. 2017 Feb;16(2):344-356. | ||||||||||
| Title: | Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities. | ||||||||||
| Author: | Talbert, Erin E|Yang, Jennifer|Mace, Thomas A|Farren, Matthew R|Farris, Alton B|Young, Gregory S|Elnaggar, Omar|Che, Zheng|Timmers, Cynthia D|Rajasekera, Priyani|Maskarinec, Jennifer M|Bloomston, Mark|Bekaii-Saab, Tanios|Guttridge, Denis C|Lesinski, Grego | ||||||||||
| PMID: | 27811010 | ||||||||||
| 27. | |||||||||||
| Journal: | Int J Mol Sci. 2017 Feb 15;18(2). pii: ijms18020418. | ||||||||||
| Title: | Targeting Angiogenesis in Biliary Tract Cancers: An Open Option. | ||||||||||
| Author: | Simone, Valeria|Brunetti, Oronzo|Lupo, Luigi|Testini, Mario|Maiorano, Eugenio|Simone, Michele|Longo, Vito|Rolfo, Christian|Peeters, Marc|Scarpa, Aldo|Azzariti, Amalia|Russo, Antonio|Ribatti, Domenico|Silvestris, Nicola | ||||||||||
| PMID: | 28212293 | ||||||||||
| 28. | |||||||||||
| Journal: | Expert Opin Ther Targets. 2017 May;21(5):485-498. | ||||||||||
| Title: | Signaling pathways as therapeutic targets in biliary tract cancer. | ||||||||||
| Author: | Yang, Jennifer|Farren, Matthew R|Ahn, Daniel|Bekaii-Saab, Tanios|Lesinski, Gregory B | ||||||||||
| PMID: | 28282502 | ||||||||||
| 29. | |||||||||||
| Journal: | Oncotarget. 2017 May 30;8(22):36319-36330. | ||||||||||
| Title: | Identification of MAP kinase pathways as therapeutic targets in gallbladder carcinoma using targeted parallel sequencing. | ||||||||||
| Author: | Li, Mengdan|Chen, Lihong|Qu, Yiping|Sui, Fang|Yang, Qi|Ji, Meiju|Shi, Bingyin|Chen, Mingwei|Hou, Peng | ||||||||||
| PMID: | 28422736 | ||||||||||
| 30. | |||||||||||
| Journal: | J Gastrointest Oncol. 2017 Apr;8(2):E32-E38. | ||||||||||
| Title: | Combined dabrafenib and trametinib treatment in a case of chemotherapy-refractory extrahepatic BRAF V600E mutant cholangiocarcinoma: dramatic clinical and radiological response with a confusing synchronic new liver lesion. | ||||||||||
| Author: | Kocsis, Judit|Arokszallasi, Anita|Andras, Csilla|Balogh, Ingrid|Beres, Edit|Deri, Julia|Petak, Istvan|Janvary, Levente|Horvath, Zsolt | ||||||||||
| PMID: | 28480077 | ||||||||||
| 31. | |||||||||||
| Journal: | Cancer Lett. 2017 Dec 28;411:162-170. | ||||||||||
| Title: | Anti-tumor effects of NVP-BKM120 alone or in combination with MEK162 in biliary tract cancer. | ||||||||||
| Author: | Jin, Ling|Jin, Mei-Hua|Nam, Ah-Rong|Park, Ji-Eun|Bang, Ju-Hee|Oh, Do-Youn|Bang, Yung-Jue | ||||||||||
| PMID: | 29024814 | ||||||||||
| 32. | |||||||||||
| Journal: | Cell Death Dis. 2018 Jan 18;9(2):31. | ||||||||||
| Title: | Efficacy of MEK inhibition in a K-Ras-driven cholangiocarcinoma preclinical model. | ||||||||||
| Author: | Dong, Mingjie|Liu, Xianqiong|Evert, Katja|Utpatel, Kirsten|Peters, Michele|Zhang, Shanshan|Xu, Zhong|Che, Li|Cigliano, Antonio|Ribback, Silvia|Dombrowski, Frank|Cossu, Antonio|Gordan, John|Calvisi, Diego F|Evert, Matthias|Liu, Yan|Chen, Xin | ||||||||||
| PMID: | 29348467 | ||||||||||
| 33. | |||||||||||
| Journal: | Cell Death Dis. 2018 Feb 7;9(2):179. | ||||||||||
| Title: | Osteopontin promotes metastasis of intrahepatic cholangiocarcinoma through recruiting MAPK1 and mediating Ser675 phosphorylation of beta-Catenin. | ||||||||||
| Author: | Zheng, Yan|Zhou, Chuang|Yu, Xin-Xin|Wu, Chao|Jia, Hu-Liang|Gao, Xiao-Mei|Yang, Ji-Meng|Wang, Chao-Qun|Luo, Qin|Zhu, Ying|Zhang, Yu|Wei, Jin-Wang|Sheng, Yuan-Yuan|Dong, Qiong-Zhu|Qin, Lun-Xiu | ||||||||||
| PMID: | 29415992 | ||||||||||
| 34. | |||||||||||
| Journal: | Cancer Med. 2018 Mar;7(3):796-808. | ||||||||||
| Title: | Elevated TRIM44 promotes intrahepatic cholangiocarcinoma progression by inducing cell EMT via MAPK signaling. | ||||||||||
| Author: | Peng, Rui|Zhang, Peng-Fei|Zhang, Chi|Huang, Xiao-Yong|Ding, Yan-Bing|Deng, Bin|Bai, Dou-Sheng|Xu, Ya-Ping | ||||||||||
| PMID: | 29446253 | ||||||||||
| 35. | |||||||||||
| Journal: | Int J Mol Sci. 2018 Oct 12;19(10). pii: ijms19103141. | ||||||||||
| Title: | MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner. | ||||||||||
| Author: | Miao, Wenyu|Sakai, Katsuya|Imamura, Ryu|Ito, Kenichiro|Suga, Hiroaki|Sakuma, Tetsushi|Yamamoto, Takashi|Matsumoto, Kunio | ||||||||||
| PMID: | 30322054 | ||||||||||