Literatures

Primary Site >> Colorectal Cancer

Gene >> MAP2K1

1.
Journal:	Oncogene. 1997 May 29;14(21):2563-73.
Title:	Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade.
Author:	Lengyel, E\|Wang, H\|Gum, R\|Simon, C\|Wang, Y\|Boyd, D
PMID:	9191056

2.
Journal:	Oncogene. 1999 Jan 7;18(1):87-92.
Title:	Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras.
Author:	Lorentz, O\|Cadoret, A\|Duluc, I\|Capeau, J\|Gespach, C\|Cherqui, G\|Freund, J N
PMID:	9926923

3.
Journal:	Cancer Res. 1999 May 15;59(10):2445-50.
Title:	Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells.
Author:	Okumura, K\|Shirasawa, S\|Nishioka, M\|Sasazuki, T
PMID:	10344756

4.
Journal:	J Biol Chem. 2000 Dec 15;275(50):39090-5.
Title:	Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells.
Author:	Ogier-Denis, E\|Pattingre, S\|El Benna, J\|Codogno, P
PMID:	10993892

5.
Journal:	Biochem J. 2000 Dec 1;352 Pt 2:419-24.
Title:	Induction of prostaglandin endoperoxide synthase 2 by mitogen-activated protein kinase cascades.
Author:	McGinty, A\|Foschi, M\|Chang, Y W\|Han, J\|Dunn, M J\|Sorokin, A
PMID:	11085935

6.
Journal:	Eur J Cell Biol. 2001 Mar;80(3):213-21.
Title:	Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells.
Author:	Chen, Y C\|Tsai, S H\|Shen, S C\|Lin, J K\|Lee, W R
PMID:	11322385

7.
Journal:	Oncogene. 2001 Dec 6;20(56):8066-74.
Title:	Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells.
Author:	Yao, J\|Xiong, S\|Klos, K\|Nguyen, N\|Grijalva, R\|Li, P\|Yu, D
PMID:	11781819

8.
Journal:	Int J Cancer. 2002 May 20;99(3):323-7.
Title:	The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells.
Author:	Elder, Douglas J E\|Halton, Dawn E\|Playle, Laura C\|Paraskeva, Christos
PMID:	11992399

9.
Journal:	Br J Cancer. 2003 Mar 10;88(5):748-53.
Title:	Opposing effects of butyrate and bile acids on apoptosis of human colon adenoma cells: differential activation of PKC and MAP kinases.
Author:	McMillan, L\|Butcher, S K\|Pongracz, J\|Lord, J M
PMID:	12618885

10.
Journal:	Cancer Sci. 2003 Oct;94(10):886-93.
Title:	Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine.
Author:	Aizawa, Shu\|Ookawa, Keizou\|Kudo, Toshihiro\|Asano, Junpei\|Hayakari, Makoto\|Tsuchida, Shigeki
PMID:	14556662

11.
Journal:	J Cell Sci. 2003 Dec 15;116(Pt 24):4957-63.
Title:	Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cells.
Author:	Vial, Emmanuel\|Marshall, Christopher J
PMID:	14625389

12.
Journal:	Genes Chromosomes Cancer. 2004 Feb;39(2):138-42.
Title:	Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation.
Author:	Domingo, Enric\|Espin, Eloi\|Armengol, Manel\|Oliveira, Carla\|Pinto, Mafalda\|Duval, Alex\|Brennetot, Caroline\|Seruca, Raquel\|Hamelin, Richard\|Yamamoto, Hiroyuki\|Schwartz, Simo Jr
PMID:	14695993

13.
Journal:	Mol Carcinog. 2004 Feb;39(2):91-102.
Title:	Suppression of polyamine catabolism by activated Ki-ras in human colon cancer cells.
Author:	Ignatenko, Natalia A\|Babbar, Naveen\|Mehta, Dipti\|Casero, Robert A Jr\|Gerner, Eugene W
PMID:	14750214

14.
Journal:	J Biol Chem. 2004 Jun 18;279(25):26176-83. Epub 2004 Apr 12.
Title:	Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK1/2 and p38 MAPK.
Author:	Nishihara, Hiroshi\|Hwang, Michael\|Kizaka-Kondoh, Shinae\|Eckmann, Lars\|Insel, Paul A
PMID:	15078890

15.
Journal:	Scand J Gastroenterol. 2004 May;39(5):464-9.
Title:	Expression patterns of cell cycle and apoptosis-related genes in a multidrug-resistant human colon carcinoma cell line.
Author:	Fan, C W\|Chan, C C\|Chao, C C K\|Fan, H A\|Sheu, D L\|Chan, E C
PMID:	15180185

16.
Journal:	Mol Cancer Ther. 2004 Jun;3(6):755-62.
Title:	Identification of 4-anilino-3-quinolinecarbonitrile inhibitors of mitogen-activated protein/extracellular signal-regulated kinase 1 kinase.
Author:	Mallon, Robert\|Feldberg, Larry\|Kim, Steven\|Collins, Karen\|Wojciechowicz, Donald\|Kohler, Constance\|Kovacs, Diana\|Discafani, Carolyn\|Zhang, Nan\|Wu, Biqi\|Floyd, Brawner\|Powell, Dennis\|Berger, Dan
PMID:	15210862

17.
Journal:	J Biol Chem. 2004 Oct 1;279(40):41377-83.
Title:	Protein phosphatase 2A, a negative regulator of the ERK signaling pathway, is activated by tyrosine phosphorylation of putative HLA class II-associated protein I (PHAPI)/pp32 in response to the antiproliferative lectin, jacalin.
Author:	Yu, Lu-Gang\|Packman, Len C\|Weldon, Mike\|Hamlett, Jane\|Rhodes, Jonathan M
PMID:	15247276

18.
Journal:	Mol Cell Probes. 2004 Oct;18(5):349-52.
Title:	Real-time allele-specific amplification for sensitive detection of the BRAF mutation V600E.
Author:	Jarry, Anne\|Masson, Damien\|Cassagnau, Elisabeth\|Parois, Sigrid\|Laboisse, Christian\|Denis, Marc G
PMID:	15294323

19.
Journal:	J Biol Chem. 2004 Oct 29;279(44):45556-63. Epub 2004 Aug 20.
Title:	Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo.
Author:	Liu, Yan\|Su, Weidong\|Thompson, E Aubrey\|Leitges, Michael\|Murray, Nicole R\|Fields, Alan P
PMID:	15322124

20.
Journal:	Cancer Res. 2004 Nov 15;64(22):8148-51.
Title:	Inhibition of extracellular-signal regulated kinases 1/2 is required for apoptosis of human colon cancer cells in vitro by sulindac metabolites.
Author:	Rice, Pamela L\|Beard, K Scott\|Driggers, Linda J\|Ahnen, Dennis J
PMID:	15548677

21.
Journal:	J Pharmacol Sci. 2005 Jan;97(1):25-30. Epub 2005 Jan 15.
Title:	Physiology and pathophysiology of proteinase-activated receptors (PARs): PAR-2-mediated proliferation of colon cancer cell.
Author:	Nishibori, Masahiro\|Mori, Shuji\|Takahashi, Hideo K
PMID:	15655297

22.
Journal:	Mol Cancer Ther. 2005 Jan;4(1):51-9.
Title:	Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells.
Author:	Sun, Yunjie\|Sinicrope, Frank A
PMID:	15657353

23.
Journal:	Oncogene. 2005 Apr 21;24(18):3011-9.
Title:	Combined inhibition of extracellular signal-regulated kinases and HSP90 sensitizes human colon carcinoma cells to ionizing radiation.
Author:	Kobayashi, Shinichiro\|Nantz, Regan\|Kitamura, Tetsuya\|Higashikubo, Ryuji\|Horikoshi, Nobuo
PMID:	15735687

24.
Journal:	Mol Pharmacol. 2005 Aug;68(2):477-86.
Title:	Characterization of a human carcinoma cell line selected for resistance to the farnesyl transferase inhibitor 4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-b)-pyri din-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxami
Author:	Bruzek, Laura M\|Poynter, Jenny N\|Kaufmann, Scott H\|Adjei, Alex A
PMID:	15901852

25.
Journal:	World J Gastroenterol. 2005 May 28;11(20):3040-5.
Title:	Molecular mechanisms of denbinobin-induced anti-tumorigenesis effect in colon cancer cells.
Author:	Yang, Kuo-Ching\|Uen, Yih-Huei\|Suk, Fat-Moon\|Liang, Yu-Chih\|Wang, Ying-Jan\|Ho, Yuan-Soon\|Li, I-Hsuan\|Lin, Shyr-Yi
PMID:	15918186

26.
Journal:	Neoplasia. 2005 Apr;7(4):336-47.
Title:	A role for K-ras in conferring resistance to the MEK inhibitor, CI-1040.
Author:	Wang, Yuli\|Van Becelaere, Keri\|Jiang, Ping\|Przybranowski, Sally\|Omer, Charles\|Sebolt-Leopold, Judith
PMID:	15967111

27.
Journal:	J Pharmacol Exp Ther. 2005 Nov;315(2):668-77. Epub 2005 Aug 3.
Title:	Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene.
Author:	Bottone, Frank G Jr\|Moon, Yuseok\|Alston-Mills, Brenda\|Eling, Thomas E
PMID:	16079301

28.
Journal:	Gastroenterology. 2005 Aug;129(2):577-90.
Title:	Oncogenic potential of MEK1 in rat intestinal epithelial cells is mediated via cyclooxygenase-2.
Author:	Komatsu, Koga\|Buchanan, F Gregory\|Katkuri, Sharada\|Morrow, Jason D\|Inoue, Hiroyasu\|Otaka, Michiro\|Watanabe, Sumio\|DuBois, Raymond N
PMID:	16083714

29.
Journal:	Oncogene. 2006 Jan 5;25(1):43-50.
Title:	Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase.
Author:	Wang, Q\|Zhou, Y\|Wang, X\|Evers, B M
PMID:	16278684

30.
Journal:	Biochim Biophys Acta. 2006 Feb;1760(2):151-7.
Title:	Radiation-induced upregulation of gamma-glutamyltransferase in colon carcinoma cells is mediated through the Ras signal transduction pathway.
Author:	Pankiv, Serhiy\|Moller, Seila\|Bjorkoy, Geir\|Moens, Ugo\|Huseby, Nils-Erik
PMID:	16386375

31.
Journal:	Mol Cancer Ther. 2006 Feb;5(2):309-16.
Title:	RRR-alpha-tocopherol succinate down-regulates oncogenic Ras signaling.
Author:	Donapaty, Sreenivasa\|Louis, Somaja\|Horvath, Elizabeth\|Kun, Jiang\|Sebti, Said M\|Malafa, Mokenge P
PMID:	16505104

32.
Journal:	J Biol Chem. 2006 May 26;281(21):14700-10. Epub 2006 Mar 30.
Title:	Attenuation of peroxisome proliferator-activated receptor gamma (PPARgamma) mediates gastrin-stimulated colorectal cancer cell proliferation.
Author:	Chang, Albert J\|Song, Diane H\|Wolfe, M Michael
PMID:	16574647

33.
Journal:	Cell Death Differ. 2006 Nov;13(11):1982-93.
Title:	Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis.
Author:	Lin, L\|Su, Z\|Lebedeva, I V\|Gupta, P\|Boukerche, H\|Rai, T\|Barber, G N\|Dent, P\|Sarkar, D\|Fisher, P B
PMID:	16575407

34.
Journal:	Biochem Pharmacol. 2006 May 28;71(11):1540-50.
Title:	The BH3-only protein, PUMA, is involved in oxaliplatin-induced apoptosis in colon cancer cells.
Author:	Wang, Xinying\|Li, Ming\|Wang, Jide\|Yeung, Chung-Man\|Zhang, Hongquan\|Kung, Hsiang-fu\|Jiang, Bo\|Lin, Marie Chia-mi
PMID:	16595125

35.
Journal:	Neoplasia. 2006 Sep;8(9):781-7.
Title:	Neurotensin phosphorylates GSK-3alpha/beta through the activation of PKC in human colon cancer cells.
Author:	Wang, Qingding\|Zhou, Yuning\|Evers, B Mark
PMID:	16984735

36.
Journal:	Mol Cancer. 2006 Nov 17;5:63.
Title:	Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells.
Author:	Komatsu, Koga\|Buchanan, F Gregory\|Otaka, Michiro\|Jin, Mario\|Odashima, Masaru\|Horikawa, Yohei\|Watanabe, Sumio\|Dubois, Raymond N
PMID:	17112382

37.
Journal:	Cancer. 2007 May 15;109(10):1996-2003.
Title:	XAF1 mediates apoptosis through an extracellular signal-regulated kinase pathway in colon cancer.
Author:	Yu, Li Fen\|Wang, Jide\|Zou, Bing\|Lin, Marie C M\|Wu, Yun Lin\|Xia, Harry H X\|Sun, Yun Wei\|Gu, Qing\|He, Hua\|Lam, S K\|Kung, Hsiang Fu\|Wong, Benjamin C Y
PMID:	17385215

38.
Journal:	Autophagy. 2007 Sep-Oct;3(5):468-71. Epub 2007 Apr 23.
Title:	Signal-dependent control of autophagy and cell death in colorectal cancer cell: the role of the p38 pathway.
Author:	Simone, Cristiano
PMID:	17495519

39.
Journal:	Gastroenterology. 2007 Jul;133(1):219-31. Epub 2007 Apr 25.
Title:	Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells.
Author:	Zhu, Feng\|Zykova, Tatyana A\|Kang, Bong Seok\|Wang, Zhe\|Ebeling, Mara C\|Abe, Yasuhito\|Ma, Wei-Ya\|Bode, Ann M\|Dong, Zigang
PMID:	17631144

40.
Journal:	Oncogene. 2007 Sep 6;26(41):6071-81. Epub 2007 Jul 30.
Title:	Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2.
Author:	Moniz, S\|Verissimo, F\|Matos, P\|Brazao, R\|Silva, E\|Kotelevets, L\|Chastre, E\|Gespach, C\|Jordan, P
PMID:	17667937

41.
Journal:	Cancer Sci. 2007 Nov;98(11):1809-16. Epub 2007 Sep 2.
Title:	Identification of JTP-70902, a p15(INK4b)-inductive compound, as a novel MEK1/2 inhibitor.
Author:	Yamaguchi, Takayuki\|Yoshida, Takayuki\|Kurachi, Reina\|Kakegawa, Junya\|Hori, Yoshikazu\|Nanayama, Toyomichi\|Hayakawa, Kazuhide\|Abe, Hiroyuki\|Takagi, Koichi\|Matsuzaki, Youichirou\|Koyama, Makoto\|Yogosawa, Shingo\|Sowa, Yoshihiro\|Yamori, Takao\|Tajima, Nobuyuki\|S
PMID:	17784872

42.
Journal:	J Med Chem. 2007 Oct 18;50(21):5090-102.
Title:	4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.
Author:	Spicer, Julie A\|Rewcastle, Gordon W\|Kaufman, Michael D\|Black, Shannon L\|Plummer, Mark S\|Denny, William A\|Quin, John 3rd\|Shahripour, Aurash B\|Barrett, Stephen D\|Whitehead, Christopher E\|Milbank, Jared B J\|Ohren, Jeffrey F\|Gowan, Richard C\|Omer, Charles\|Cam
PMID:	17880056

43.
Journal:	J Biol Chem. 2008 Feb 22;283(8):5023-33. Epub 2007 Dec 17.
Title:	Suppression of v-Src transformation by andrographolide via degradation of the v-Src protein and attenuation of the Erk signaling pathway.
Author:	Liang, Fong-Pin\|Lin, Chao-Hsiung\|Kuo, Cheng-Deng\|Chao, Hsueh-Ping\|Fu, Shu-Ling
PMID:	18086662

44.
Journal:	Hum Mutat. 2008 Mar;29(3):441-50.
Title:	Rapid identification of somatic mutations in colorectal and breast cancer tissues using mismatch repair detection (MRD).
Author:	Bentivegna, Steven\|Zheng, Jianbiao\|Namsaraev, Eugeni\|Carlton, Victoria E H\|Pavlicek, Adam\|Moorhead, Martin\|Siddiqui, Farooq\|Wang, Zhiyong\|Lee, Liana\|Ireland, James S\|Suyenaga, Kent\|Willis, Thomas D\|Faham, Malek\|Seymour, Albert B
PMID:	18186519

45.
Journal:	Anticancer Res. 2008 Mar-Apr;28(2A):895-906.
Title:	Rosiglitazone induces caveolin-1 by PPARgamma-dependent and PPRE-independent mechanisms: the role of EGF receptor signaling and its effect on cancer cell drug resistance.
Author:	Tencer, Lilach\|Burgermeister, Elke\|Ebert, Matthias P\|Liscovitch, Mordechai
PMID:	18507034

46.
Journal:	Biochem Biophys Res Commun. 2008 Aug 8;372(4):845-9.
Title:	Major contribution of MEK1 to the activation of ERK1/ERK2 and to the growth of LS174T colon carcinoma cells.
Author:	Shama, Jessica\|Garcia-Medina, Raquel\|Pouyssegur, Jacques\|Vial, Emmanuel
PMID:	18533112

47.
Journal:	Cancer Res. 2008 Aug 1;68(15):6324-30.
Title:	Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives.
Author:	Fukuyo, Yayoi\|Inoue, Masahiro\|Nakajima, Takuma\|Higashikubo, Ryuji\|Horikoshi, Nobuko T\|Hunt, Clayton\|Usheva, Anny\|Freeman, Michael L\|Horikoshi, Nobuo
PMID:	18676857

48.
Journal:	Anticancer Res. 2008 Jul-Aug;28(4B):2067-76.
Title:	Inhibition of growth and induction of differentiation of colon cancer cells by peach and plum phenolic compounds.
Author:	Lea, Michael A\|Ibeh, Chinwe\|desBordes, Charles\|Vizzotto, Marcia\|Cisneros-Zevallos, Luis\|Byrne, David H\|Okie, William R\|Moyer, Mary P
PMID:	18751377

49.
Journal:	Toxicol Appl Pharmacol. 2008 Nov 1;232(3):408-17.
Title:	Reciprocal regulation of extracellular signal regulated kinase 1/2 and mitogen activated protein kinase phosphatase-3.
Author:	Zeliadt, Nicholette A\|Mauro, Laura J\|Wattenberg, Elizabeth V
PMID:	18771677

50.
Journal:	Mol Cancer Ther. 2008 Sep;7(9):3112-21.
Title:	Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901.
Author:	Leyton, Julius\|Smith, Graham\|Lees, Mark\|Perumal, Meg\|Nguyen, Quang-de\|Aigbirhio, Franklin I\|Golovko, Oksana\|He, Quimin\|Workman, Paul\|Aboagye, Eric O
PMID:	18790789

51.
Journal:	Oncogene. 2008 Dec 4;27(57):7150-61.
Title:	Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM.
Author:	Wickenden, J A\|Jin, H\|Johnson, M\|Gillings, A S\|Newson, C\|Austin, M\|Chell, S D\|Balmanno, K\|Pritchard, C A\|Cook, S J
PMID:	18806830

52.
Journal:	BMC Cancer. 2008 Nov 17;8:337.
Title:	Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors.
Author:	Voisin, Laure\|Julien, Catherine\|Duhamel, Stephanie\|Gopalbhai, Kailesh\|Claveau, Isabelle\|Saba-El-Leil, Marc K\|Rodrigue-Gervais, Ian Gael\|Gaboury, Louis\|Lamarre, Daniel\|Basik, Mark\|Meloche, Sylvain
PMID:	19014680

53.
Journal:	J Pharmacol Exp Ther. 2009 Apr;329(1):360-7.
Title:	Pharmacodynamics of 2-[4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyraz ol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: understanding relationships between systemic concentrations, phosphorylated
Author:	Wong, Harvey\|Belvin, Marcia\|Herter, Sylvia\|Hoeflich, Klaus P\|Murray, Lesley J\|Wong, Leo\|Choo, Edna F
PMID:	19147858

54.
Journal:	Am J Physiol Renal Physiol. 2009 Apr;296(4):F723-9.
Title:	Netrin-1 increases proliferation and migration of renal proximal tubular epithelial cells via the UNC5B receptor.
Author:	Wang, Weiwei\|Reeves, W Brian\|Ramesh, Ganesan
PMID:	19211685

55.
Journal:	Mol Cell Biochem. 2009 Aug;328(1-2):201-8.
Title:	MAP kinases in proliferating human colon cancer Caco-2 cells.
Author:	Buzzi, Natalia\|Colicheo, Andrea\|Boland, Ricardo\|de Boland, Ana Russo
PMID:	19301097

56.
Journal:	Clin Cancer Res. 2009 Apr 15;15(8):2647-56.
Title:	Role of eotaxin-1 signaling in ovarian cancer.
Author:	Levina, Vera\|Nolen, Brian M\|Marrangoni, Adele M\|Cheng, Peng\|Marks, Jeffrey R\|Szczepanski, Miroslaw J\|Szajnik, Marta E\|Gorelik, Elieser\|Lokshin, Anna E
PMID:	19351767

57.
Journal:	Mol Cancer Ther. 2009 Apr;8(4):834-43.
Title:	KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer.
Author:	Yeh, Jen Jen\|Routh, Elizabeth D\|Rubinas, Tara\|Peacock, Janie\|Martin, Timothy D\|Shen, Xiang Jun\|Sandler, Robert S\|Kim, Hong Jin\|Keku, Temitope O\|Der, Channing J
PMID:	19372556

58.
Journal:	Cell Cycle. 2009 Jul 1;8(13):2122-4. Epub 2009 Jul 9.
Title:	MEK1 mutations, but not ERK2 mutations, occur in melanomas and colon carcinomas, but none in thyroid carcinomas.
Author:	Murugan, Avaniyapuram Kannan\|Dong, Jianli\|Xie, Jingwu\|Xing, Mingzhao
PMID:	19411838

59.
Journal:	IUBMB Life. 2009 Jun;61(6):685-92.
Title:	Tax1 enhances cancer cell proliferation via Ras-Raf-MEK-ERK signaling pathway.
Author:	Song, Chunjiao\|Wang, Weimin\|Li, Meng\|Liu, Yanxin\|Zheng, Dexian
PMID:	19472191

60.
Journal:	PLoS One. 2009 May 27;4(5):e5717.
Title:	Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors.
Author:	Jaiswal, Bijay S\|Janakiraman, Vasantharajan\|Kljavin, Noelyn M\|Eastham-Anderson, Jeffrey\|Cupp, James E\|Liang, Yuxin\|Davis, David P\|Hoeflich, Klaus P\|Seshagiri, Somasekar
PMID:	19492075

61.
Journal:	Int J Cancer. 2009 Nov 15;125(10):2332-41.
Title:	Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines.
Author:	Balmanno, Kathryn\|Chell, Simon D\|Gillings, Annette S\|Hayat, Shaista\|Cook, Simon J
PMID:	19637312

62.
Journal:	Clin Cancer Res. 2009 Nov 1;15(21):6619-29.
Title:	The mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) enhances the radiation responsiveness of lung and colorectal tumor xenografts.
Author:	Shannon, Aoife M\|Telfer, Brian A\|Smith, Paul D\|Babur, Muhammed\|Logie, Armelle\|Wilkinson, Robert W\|Debray, Camille\|Stratford, Ian J\|Williams, Kaye J\|Wedge, Stephen R
PMID:	19843666

63.
Journal:	Cancer Lett. 2010 Apr 1;290(1):123-8.
Title:	Lithocholic acid upregulates uPAR and cell invasiveness via MAPK and AP-1 signaling in colon cancer cells.
Author:	Baek, Min Kyung\|Park, Jung Sun\|Park, Ji Hye\|Kim, Mi Ha\|Kim, Ho Dong\|Bae, Woo Kyun\|Chung, Ik Joo\|Shin, Boo Ahn\|Jung, Young Do
PMID:	19782465

64.
Journal:	Mol Cancer Ther. 2010 Jan;9(1):134-44.
Title:	Preclinical in vivo evaluation of efficacy, pharmacokinetics, and pharmacodynamics of a novel MEK1/2 kinase inhibitor RO5068760 in multiple tumor models.
Author:	Daouti, Sherif\|Higgins, Brian\|Kolinsky, Kenneth\|Packman, Kathryn\|Wang, Huisheng\|Rizzo, Christine\|Moliterni, John\|Huby, Nicholas\|Fotouhi, Nader\|Liu, Mei\|Goelzer, Petra\|Sandhu, Harpreet K\|Li, Jia Kui\|Railkar, Aruna\|Heimbrook, David\|Niu, Huifeng
PMID:	20053779

65.
Journal:	Int J Oncol. 2010 Apr;36(4):941-53.
Title:	Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway.
Author:	Lee, Hwa Young\|Crawley, Suzanne\|Hokari, Ryota\|Kwon, Sungwon\|Kim, Young S
PMID:	20198339

66.
Journal:	Cell Oncol. 2010 Jan 1;32(4):245-57.
Title:	Oncogenic K-ras activates p38 to maintain colorectal cancer cell proliferation during MEK inhibition.
Author:	van Houdt, Winan J\|de Bruijn, Menno T\|Emmink, Benjamin L\|Raats, Danielle\|Hoogwater, Frederik J H\|Borel Rinkes, Inne H M\|Kranenburg, Onno
PMID:	20413844

67.
Journal:	Genes Chromosomes Cancer. 2010 Nov;49(11):1024-34.
Title:	Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas.
Author:	Gaedcke, Jochen\|Grade, Marian\|Jung, Klaus\|Camps, Jordi\|Jo, Peter\|Emons, Georg\|Gehoff, Anastasia\|Sax, Ulrich\|Schirmer, Markus\|Becker, Heinz\|Beissbarth, Tim\|Ried, Thomas\|Ghadimi, B Michael
PMID:	20725992

68.
Journal:	Mol Cancer Ther. 2010 Dec;9(12):3351-62.
Title:	Identification of predictive markers of response to the MEK1/2 inhibitor selumetinib (AZD6244) in K-ras-mutated colorectal cancer.
Author:	Tentler, John J\|Nallapareddy, Sujatha\|Tan, Aik Choon\|Spreafico, Anna\|Pitts, Todd M\|Morelli, M Pia\|Selby, Heather M\|Kachaeva, Maria I\|Flanigan, Sara A\|Kulikowski, Gillian N\|Leong, Stephen\|Arcaroli, John J\|Messersmith, Wells A\|Eckhardt, S Gail
PMID:	20923857

69.
Journal:	Mol Cancer. 2010 Oct 13;9:271.
Title:	The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis.
Author:	Bergeron, Sebastien\|Lemieux, Etienne\|Durand, Veronique\|Cagnol, Sebastien\|Carrier, Julie C\|Lussier, Jacques G\|Boucher, Marie-Josee\|Rivard, Nathalie
PMID:	20942929

70.
Journal:	Invest New Drugs. 2011 Oct;29(5):1021-8.
Title:	A Phase II, open-label, randomised study to assess the efficacy and safety of the MEK1/2 inhibitor AZD6244 (ARRY-142886) versus capecitabine monotherapy in patients with colorectal cancer who have failed one or two prior chemotherapeutic regimens.
Author:	Bennouna, Jaafar\|Lang, Istvan\|Valladares-Ayerbes, Manuel\|Boer, Katalin\|Adenis, Antoine\|Escudero, Pilar\|Kim, Tae-You\|Pover, Gillian M\|Morris, Clive D\|Douillard, Jean-Yves
PMID:	20127139

71.
Journal:	Oncol Rep. 2011 Jan;25(1):223-30.
Title:	Esculetin inhibits cell proliferation through the Ras/ERK1/2 pathway in human colon cancer cells.
Author:	Park, Sung-Suk\|Park, Sung-Kyu\|Lim, Jung-Hyurk\|Choi, Yung Hyun\|Kim, Wun-Jae\|Moon, Sung-Kwon
PMID:	21109980

72.
Journal:	Cancer Res. 2011 Jan 15;71(2):445-53.
Title:	MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy.
Author:	Yoon, Juyong\|Koo, Kyoung-Hwa\|Choi, Kang-Yell
PMID:	21118963

73.
Journal:	Cancer Res. 2011 Feb 1;71(3):1071-80.
Title:	Oncogenic Kras promotes chemotherapy-induced growth factor shedding via ADAM17.
Author:	Van Schaeybroeck, Sandra\|Kyula, Joan N\|Fenton, Audrey\|Fenning, Catherine S\|Sasazuki, Takehiko\|Shirasawa, Senji\|Longley, Daniel B\|Johnston, Patrick G
PMID:	21148749

74.
Journal:	Mol Cancer Res. 2011 Feb;9(2):173-82.
Title:	Functional genomics reveals diverse cellular processes that modulate tumor cell response to oxaliplatin.
Author:	Harradine, Kelly A\|Kassner, Michelle\|Chow, Donald\|Aziz, Meraj\|Von Hoff, Daniel D\|Baker, Joffre B\|Yin, Hongwei\|Pelham, Robert J
PMID:	21169384

75.
Journal:	Cancer Res. 2011 Jan 1;71(1):206-15.
Title:	Activation and involvement of Ral GTPases in colorectal cancer.
Author:	Martin, Timothy D\|Samuel, Jonathan C\|Routh, Elizabeth D\|Der, Channing J\|Yeh, Jen Jen
PMID:	21199803

76.
Journal:	Carcinogenesis. 2011 Jun;32(6):921-8.
Title:	Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPK.
Author:	Kang, Nam Joo\|Lee, Ki Won\|Kim, Bo Hyun\|Bode, Ann M\|Lee, Hyo-Jeong\|Heo, Yong-Seok\|Boardman, Lisa\|Limburg, Paul\|Lee, Hyong Joo\|Dong, Zigang
PMID:	21317303

77.
Journal:	Sci Signal. 2011 Mar 29;4(166):ra17.
Title:	Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells.
Author:	Little, Annette S\|Balmanno, Kathryn\|Sale, Matthew J\|Newman, Scott\|Dry, Jonathan R\|Hampson, Mark\|Edwards, Paul A W\|Smith, Paul D\|Cook, Simon J
PMID:	21447798

78.
Journal:	Int J Oncol. 2011 Jul;39(1):23-31.
Title:	Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo.
Author:	Yamaguchi, Takayuki\|Kakefuda, Reina\|Tajima, Nobuyuki\|Sowa, Yoshihiro\|Sakai, Toshiyuki
PMID:	21523318

79.
Journal:	Sci Signal. 2011;4(170):er2.
Title:	A correction to the research article titled: "Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells" by A. S. Little, K. Balmanno, M. J. Sale, S. Newman, J. R. Dry, M. Hampson, P
Author:	Little, Annette S\|Balmanno, Kathryn\|Sale, Matthew J\|Newman, Scott\|Dry, Jonathan R\|Hampson, Mark\|Edwards, Paul A W\|Smith, Paul D\|Cook, Simon J
PMID:	21674991

80.
Journal:	Cancer Res. 2011 Aug 15;71(16):5535-45.
Title:	Identification of the MEK1(F129L) activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation.
Author:	Wang, Huisheng\|Daouti, Sherif\|Li, Wen-Hui\|Wen, Yang\|Rizzo, Christine\|Higgins, Brian\|Packman, Kathryn\|Rosen, Neal\|Boylan, John F\|Heimbrook, David\|Niu, Huifeng
PMID:	21705440

81.
Journal:	PLoS One. 2011;6(8):e23381.
Title:	An RNA interference phenotypic screen identifies a role for FGF signals in colon cancer progression.
Author:	Leushacke, Marc\|Sporle, Ralf\|Bernemann, Christof\|Brouwer-Lehmitz, Antje\|Fritzmann, Johannes\|Theis, Mirko\|Buchholz, Frank\|Herrmann, Bernhard G\|Morkel, Markus
PMID:	21853123

82.
Journal:	J Exp Clin Cancer Res. 2011 Sep 16;30:83.
Title:	Effects of metastasis-associated in colon cancer 1 inhibition by small hairpin RNA on ovarian carcinoma OVCAR-3 cells.
Author:	Zhang, Ruitao\|Shi, Huirong\|Chen, Zhimin\|Wu, Qinghua\|Ren, Fang\|Huang, Haoliang
PMID:	21923915

83.
Journal:	Br J Cancer. 2011 Nov 22;105(11):1759-67.
Title:	Chemoresistant colorectal cancer cells and cancer stem cells mediate growth and survival of bystander cells.
Author:	Bose, D\|Zimmerman, L J\|Pierobon, M\|Petricoin, E\|Tozzi, F\|Parikh, A\|Fan, F\|Dallas, N\|Xia, L\|Gaur, P\|Samuel, S\|Liebler, D C\|Ellis, L M
PMID:	22045189

84.
Journal:	Int J Colorectal Dis. 2012 Apr;27(4):437-45.
Title:	Tissue factor/activated factor VIIa induces matrix metalloproteinase-7 expression through activation of c-Fos via ERK1/2 and p38 MAPK signaling pathways in human colon cancer cell.
Author:	Jia, Zhi-Chao\|Wan, Yuan-Lian\|Tang, Jian-Qiang\|Dai, Yun\|Liu, Yu-Cun\|Wang, Xin\|Zhu, Jing
PMID:	22076613

85.
Journal:	Mol Cancer Ther. 2012 Mar;11(3):720-9.
Title:	Comprehensive predictive biomarker analysis for MEK inhibitor GSK1120212.
Author:	Jing, Junping\|Greshock, Joel\|Holbrook, Joanna Dawn\|Gilmartin, Aidan\|Zhang, Xiping\|McNeil, Elizabeth\|Conway, Theresa\|Moy, Christopher\|Laquerre, Sylvie\|Bachman, Kurt\|Wooster, Richard\|Degenhardt, Yan
PMID:	22169769

86.
Journal:	Biochem Soc Trans. 2012 Feb;40(1):73-8.
Title:	Tumour cell responses to MEK1/2 inhibitors: acquired resistance and pathway remodelling.
Author:	Little, Annette S\|Balmanno, Kathryn\|Sale, Matthew J\|Smith, Paul D\|Cook, Simon J
PMID:	22260668

87.
Journal:	Cancer Res. 2012 Feb 1;72(3):626-35.
Title:	Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation.
Author:	Duhamel, Stephanie\|Hebert, Josee\|Gaboury, Louis\|Bouchard, Amelie\|Simon, Ronald\|Sauter, Guido\|Basik, Mark\|Meloche, Sylvain
PMID:	22298595

88.
Journal:	Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G1006-15.
Title:	Src-mediated aryl hydrocarbon and epidermal growth factor receptor cross talk stimulates colon cancer cell proliferation.
Author:	Xie, Guofeng\|Peng, Zhongsheng\|Raufman, Jean-Pierre
PMID:	22361730

89.
Journal:	Nutr Cancer. 2012;64(4):559-68.
Title:	Ras signaling pathway in the chemopreventive action of different ratios of fish oil and corn oil in experimentally induced colon carcinogenesis.
Author:	Kansal, S\|Negi, A K\|Bhatnagar, A\|Agnihotri, N
PMID:	22519408

90.
Journal:	Br J Cancer. 2012 May 8;106(10):1648-59.
Title:	Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells.
Author:	Troiani, T\|Vecchione, L\|Martinelli, E\|Capasso, A\|Costantino, S\|Ciuffreda, L P\|Morgillo, F\|Vitagliano, D\|D'Aiuto, E\|De Palma, R\|Tejpar, S\|Van Cutsem, E\|De Lorenzi, M\|Caraglia, M\|Berrino, L\|Ciardiello, F
PMID:	22569000

91.
Journal:	Cancer Lett. 2012 Nov 1;324(1):98-108.
Title:	Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models.
Author:	Chiacchiera, Fulvio\|Grossi, Valentina\|Cappellari, Marianna\|Peserico, Alessia\|Simonatto, Marta\|Germani, Aldo\|Russo, Silvana\|Moyer, Mary P\|Resta, Nicoletta\|Murzilli, Stefania\|Simone, Cristiano
PMID:	22579651

92.
Journal:	Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):E2127-33.
Title:	Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
Author:	Ohashi, Kadoaki\|Sequist, Lecia V\|Arcila, Maria E\|Moran, Teresa\|Chmielecki, Juliann\|Lin, Ya-Lun\|Pan, Yumei\|Wang, Lu\|de Stanchina, Elisa\|Shien, Kazuhiko\|Aoe, Keisuke\|Toyooka, Shinichi\|Kiura, Katsuyuki\|Fernandez-Cuesta, Lynnette\|Fidias, Panos\|Yang, James Chi
PMID:	22773810

93.
Journal:	Carcinogenesis. 2012 Dec;33(12):2398-408.
Title:	MAP kinase genes and colon and rectal cancer.
Author:	Slattery, Martha L\|Lundgreen, Abbie\|Wolff, Roger K
PMID:	23027623

94.
Journal:	Anal Quant Cytopathol Histpathol. 2012 Dec;34(6):309-16.
Title:	Quantitative analysis of ERK signaling inhibition in colon cancer cell lines using phospho-specific flow cytometry.
Author:	Lim, Sun Min\|Hwang, Jee Won\|Bae, Soo Kyung\|Bae, Soo Hyeon\|Ahn, Joong Bae\|Rha, Sun Young\|Roh, Jae Kyung\|Chung, Hyun Cheol\|Shin, Sang Joon
PMID:	23304816

95.
Journal:	World J Nucl Med. 2012 May;11(2):65-9.
Title:	(18)F-FLT-PET for Response Evaluation of MEK Inhibitor Selumetinib (AZD6244, ARRY-142886) in Patients with Solid Tumors.
Author:	Desar, Ingrid M E\|Gilles, Rozemarie\|van Herpen, Carla M L\|Timmer-Bonte, Anja J N H\|Cantarini, Mireille V\|van der Graaf, Winette T A\|Oyen, Wim J G
PMID:	23372439

96.
Journal:	Int J Cancer. 2013 Feb 1;132(3):E149-57.
Title:	Mitogen-activated protein kinase (MEK/ERK) inhibition sensitizes cancer cells to centromere-associated protein E inhibition.
Author:	Mayes, Patrick A\|Degenhardt, Yan Y\|Wood, Andrew\|Toporovskya, Yana\|Diskin, Sharon J\|Haglund, Elizabeth\|Moy, Christopher\|Wooster, Richard\|Maris, John M
PMID:	22948716

97.
Journal:	Biochem J. 2013 Mar 1;450(2):285-94.
Title:	The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance.
Author:	Sale, Matthew J\|Cook, Simon J
PMID:	23234544

98.
Journal:	Cancer Res. 2013 Mar 15;73(6):1912-21.
Title:	Mixed lineage kinase MLK4 is activated in colorectal cancers where it synergistically cooperates with activated RAS signaling in driving tumorigenesis.
Author:	Martini, Miriam\|Russo, Mariangela\|Lamba, Simona\|Vitiello, Elisa\|Crowley, Emily Hannah\|Sassi, Francesco\|Romanelli, Davide\|Frattini, Milo\|Marchetti, Antonio\|Bardelli, Alberto
PMID:	23319808

99.
Journal:	Hepatology. 2013 Jun;57(6):2299-313.
Title:	MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer.
Author:	Peng, Hui\|Dara, Lily\|Li, Tony W H\|Zheng, Yuhua\|Yang, Heping\|Tomasi, Maria Lauda\|Tomasi, Ivan\|Giordano, Pasquale\|Mato, Jose M\|Lu, Shelly C
PMID:	23325601

100.
Journal:	Autophagy. 2013 May;9(5):697-713.
Title:	Energy deprivation by silibinin in colorectal cancer cells: a double-edged sword targeting both apoptotic and autophagic machineries.
Author:	Raina, Komal\|Agarwal, Chapla\|Wadhwa, Ritambhara\|Serkova, Natalie J\|Agarwal, Rajesh
PMID:	23445752

101.
Journal:	Clin Cancer Res. 2013 Aug 1;19(15):4149-62.
Title:	Rational combination of a MEK inhibitor, selumetinib, and the Wnt/calcium pathway modulator, cyclosporin A, in preclinical models of colorectal cancer.
Author:	Spreafico, Anna\|Tentler, John J\|Pitts, Todd M\|Tan, Aik Choon\|Gregory, Mark A\|Arcaroli, John J\|Klauck, Peter J\|McManus, Martine C\|Hansen, Ryan J\|Kim, Jihye\|Micel, Lindsey N\|Selby, Heather M\|Newton, Timothy P\|McPhillips, Kelly L\|Gustafson, Daniel L\|Degregor
PMID:	23757356

102.
Journal:	Drugs. 2013 Jul;73(11):1245-54.
Title:	Trametinib: first global approval.
Author:	Wright, Cameron J M\|McCormack, Paul L
PMID:	23846731

103.
Journal:	Br J Cancer. 2013 Sep 17;109(6):1562-9.
Title:	Acute tumour response to the MEK1/2 inhibitor selumetinib (AZD6244, ARRY-142886) evaluated by non-invasive diffusion-weighted MRI.
Author:	Beloueche-Babari, M\|Jamin, Y\|Arunan, V\|Walker-Samuel, S\|Revill, M\|Smith, P D\|Halliday, J\|Waterton, J C\|Barjat, H\|Workman, P\|Leach, M O\|Robinson, S P
PMID:	23942066

104.
Journal:	Cancer Biol Ther. 2013 Oct 1;14(10):877-8.
Title:	Multi-kinase modulation for colon cancer therapy.
Author:	Dent, Paul
PMID:	24025253

105.
Journal:	Clin Cancer Res. 2013 Nov 15;19(22):6219-29.
Title:	Overcoming IGF1R/IR resistance through inhibition of MEK signaling in colorectal cancer models.
Author:	Flanigan, Sara A\|Pitts, Todd M\|Newton, Timothy P\|Kulikowski, Gillian N\|Tan, Aik Choon\|McManus, Martine C\|Spreafico, Anna\|Kachaeva, Maria I\|Selby, Heather M\|Tentler, John J\|Eckhardt, S Gail\|Leong, Stephen
PMID:	24045180

106.
Journal:	J Clin Oncol. 2013 Dec 10;31(35):e448-51.
Title:	BRAF inhibitor-driven tumor proliferation in a KRAS-mutated colon carcinoma is not overcome by MEK1/2 inhibition.
Author:	Andrews, Miles C\|Behren, Andreas\|Chionh, Fiona\|Mariadason, John\|Vella, Laura J\|Do, Hongdo\|Dobrovic, Alexander\|Tebbutt, Niall\|Cebon, Jonathan
PMID:	24190114

107.
Journal:	J Cell Sci. 2014 Feb 15;127(Pt 4):788-800.
Title:	Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation.
Author:	Cope, Claire L\|Gilley, Rebecca\|Balmanno, Kathryn\|Sale, Matthew J\|Howarth, Karen D\|Hampson, Mark\|Smith, Paul D\|Guichard, Sylvie M\|Cook, Simon J
PMID:	24363449

108.
Journal:	Biochem Pharmacol. 2014 Mar 15;88(2):150-7.
Title:	Paris saponin VII inhibits growth of colorectal cancer cells through Ras signaling pathway.
Author:	Li, Yuhua\|Sun, Yang\|Fan, Lei\|Zhang, Feng\|Meng, Jin\|Han, Jin\|Guo, Xin\|Zhang, Dian\|Zhang, Rong\|Yue, Zhenggang\|Mei, Qibing
PMID:	24462916

109.
Journal:	Sci Transl Med. 2014 Feb 19;6(224):224ra26.
Title:	Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer.
Author:	Misale, Sandra\|Arena, Sabrina\|Lamba, Simona\|Siravegna, Giulia\|Lallo, Alice\|Hobor, Sebastijan\|Russo, Mariangela\|Buscarino, Michela\|Lazzari, Luca\|Sartore-Bianchi, Andrea\|Bencardino, Katia\|Amatu, Alessio\|Lauricella, Calogero\|Valtorta, Emanuele\|Siena, Salvato
PMID:	24553387

110.
Journal:	Ann Surg Oncol. 2014 Aug;21(8):2642-9.
Title:	The frequencies and clinical implications of mutations in 33 kinase-related genes in locally advanced rectal cancer: a pilot study.
Author:	Abdul-Jalil, Khairun I\|Sheehan, Katherine M\|Toomey, Sinead\|Schmid, Jasmin\|Prehn, Jochen\|O'Grady, Anthony\|Cummins, Robert\|O'Neill, Brian\|McNamara, Deborah A\|Deasy, Joseph\|Breathnach, Oscar\|Grogan, Liam\|Rogers, Ailin\|Doherty, Glen\|Winter, Des\|Ryan, John\|El-
PMID:	24700299

111.
Journal:	Recent Results Cancer Res. 2014;201:241-8.
Title:	Trametinib.
Author:	Zeiser, Robert
PMID:	24756797

112.
Journal:	Biochim Biophys Acta. 2014 Aug;1840(8):2651-61.
Title:	EGFR and HER2 exert distinct roles on colon cancer cell functional properties and expression of matrix macromolecules.
Author:	Ellina, Maria-Ioanna\|Bouris, Panagiotis\|Aletras, Alexios J\|Theocharis, Achilleas D\|Kletsas, Dimitris\|Karamanos, Nikos K
PMID:	24792576

113.
Journal:	Clin Cancer Res. 2014 Jul 15;20(14):3775-86.
Title:	Primary and acquired resistance of colorectal cancer cells to anti-EGFR antibodies converge on MEK/ERK pathway activation and can be overcome by combined MEK/EGFR inhibition.
Author:	Troiani, Teresa\|Napolitano, Stefania\|Vitagliano, Donata\|Morgillo, Floriana\|Capasso, Anna\|Sforza, Vincenzo\|Nappi, Anna\|Ciardiello, Davide\|Ciardiello, Fortunato\|Martinelli, Erika
PMID:	24812410

114.
Journal:	Mol Cancer. 2014 May 24;13:122.
Title:	Genetic targeting of B-RafV600E affects survival and proliferation and identifies selective agents against BRAF-mutant colorectal cancer cells.
Author:	Hirschi, Benjamin\|Gallmeier, Eike\|Ziesch, Andreas\|Marschall, Maximilian\|Kolligs, Frank T
PMID:	24885690

115.
Journal:	PLoS One. 2014 Jun 5;9(6):e99257.
Title:	Disruption of interleukin-1beta autocrine signaling rescues complex I activity and improves ROS levels in immortalized epithelial cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function.
Author:	Clauzure, Mariangeles\|Valdivieso, Angel G\|Massip Copiz, Maria M\|Schulman, Gustavo\|Teiber, Maria Luz\|Santa-Coloma, Tomas A
PMID:	24901709

116.
Journal:	Biomed Res Int. 2014;2014:568693.
Title:	Biological and molecular effects of small molecule kinase inhibitors on low-passage human colorectal cancer cell lines.
Author:	Lange, Falko\|Franz, Benjamin\|Maletzki, Claudia\|Linnebacher, Michael\|Huhns, Maja\|Jaster, Robert
PMID:	25309914

117.
Journal:	Neoplasia. 2014 Oct 23;16(10):845-60.
Title:	Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation.
Author:	Grasso, Silvina\|Tristante, Elena\|Saceda, Miguel\|Carbonell, Pablo\|Mayor-Lopez, Leticia\|Carballo-Santana, Mar\|Carrasco-Garcia, Estefania\|Rocamora-Reverte, Lourdes\|Garcia-Morales, Pilar\|Carballo, Fernando\|Ferragut, Jose A\|Martinez-Lacaci, Isabel
PMID:	25379021

118.
Journal:	Free Radic Biol Med. 2014 Oct;75 Suppl 1:S27.
Title:	The effect of resveratrol on signal transduction pathways and the role of pro-apoptotic Bax protein on apoptosis in HCT- 116 colon carcinoma cell lines.
Author:	Crek, Ceyda\|Mutlu Altundag, Ergul\|Karademir, Betul\|Kocturk, Semra\|Kartal Ozer, Nesrin\|Taga, Yavuz
PMID:	26461322

119.
Journal:	Biochim Biophys Acta. 2015 Feb;1852(2):277-89.
Title:	Netrin-1 improves post-injury cardiac function in vivo via DCC/NO-dependent preservation of mitochondrial integrity, while attenuating autophagy.
Author:	Bouhidel, Jalaleddinne Omar\|Wang, Ping\|Siu, Kin Lung\|Li, Hong\|Youn, Ji Youn\|Cai, Hua
PMID:	24928309

120.
Journal:	Tumour Biol. 2015 Feb;36(2):1091-7.
Title:	Combine MEK inhibition with PI3K/mTOR inhibition exert inhibitory tumor growth effect on KRAS and PIK3CA mutation CRC xenografts due to reduced expression of VEGF and matrix metallopeptidase-9.
Author:	E, Jifu\|Xing, Junjie\|Gong, Haifeng\|He, Jian\|Zhang, Wei
PMID:	25326806

121.
Journal:	Oncogene. 2015 Sep 17;34(38):4914-27.
Title:	Oncogenic KRAS signalling promotes the Wnt/beta-catenin pathway through LRP6 in colorectal cancer.
Author:	Lemieux, E\|Cagnol, S\|Beaudry, K\|Carrier, J\|Rivard, N
PMID:	25500543

122.
Journal:	Cancer Discov. 2015 Apr;5(4):358-67.
Title:	Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations.
Author:	Ahronian, Leanne G\|Sennott, Erin M\|Van Allen, Eliezer M\|Wagle, Nikhil\|Kwak, Eunice L\|Faris, Jason E\|Godfrey, Jason T\|Nishimura, Koki\|Lynch, Kerry D\|Mermel, Craig H\|Lockerman, Elizabeth L\|Kalsy, Anuj\|Gurski, Joseph M Jr\|Bahl, Samira\|Anderka, Kristin\|Green,
PMID:	25673644

123.
Journal:	Hum Pathol. 2015 Apr;46(4):507-13.
Title:	Novel molecular insights from routine genotyping of colorectal carcinomas.
Author:	Stachler, Matthew D\|Rinehart, Elizabeth\|Lindeman, Neal\|Odze, Robert\|Srivastava, Amitabh
PMID:	25683705

124.
Journal:	Am J Pathol. 2015 Apr;185(4):1135-44.
Title:	Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells.
Author:	Peng, Hui\|Li, Tony W H\|Yang, Heping\|Moyer, Mary P\|Mato, Jose M\|Lu, Shelly C
PMID:	25794709

125.
Journal:	Clin Cancer Res. 2015 Jul 15;21(14):3230-3240.
Title:	HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL.
Author:	Carson, Robbie\|Celtikci, Basak\|Fenning, Cathy\|Javadi, Arman\|Crawford, Nyree\|Carbonell, Lucia Perez\|Lawler, Mark\|Longley, Daniel B\|Johnston, Patrick G\|Van Schaeybroeck, Sandra
PMID:	25813020

126.
Journal:	Nat Med. 2015 Jul;21(7):795-801.
Title:	Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.
Author:	Siravegna, Giulia\|Mussolin, Benedetta\|Buscarino, Michela\|Corti, Giorgio\|Cassingena, Andrea\|Crisafulli, Giovanni\|Ponzetti, Agostino\|Cremolini, Chiara\|Amatu, Alessio\|Lauricella, Calogero\|Lamba, Simona\|Hobor, Sebastijan\|Avallone, Antonio\|Valtorta, Emanuele\|R
PMID:	26030179

127.
Journal:	Onco Targets Ther. 2015 Jul 8;8:1691-9.
Title:	Screening of potential diagnostic markers and therapeutic targets against colorectal cancer.
Author:	Tian, XiaoQing\|Sun, DanFeng\|Zhao, ShuLiang\|Xiong, Hua\|Fang, JingYuan
PMID:	26185457

128.
Journal:	Nature. 2015 Oct 8;526(7572):263-7.
Title:	The genomic landscape of response to EGFR blockade in colorectal cancer.
Author:	Bertotti, Andrea\|Papp, Eniko\|Jones, Sian\|Adleff, Vilmos\|Anagnostou, Valsamo\|Lupo, Barbara\|Sausen, Mark\|Phallen, Jillian\|Hruban, Carolyn A\|Tokheim, Collin\|Niknafs, Noushin\|Nesselbush, Monica\|Lytle, Karli\|Sassi, Francesco\|Cottino, Francesca\|Migliardi, Giorg
PMID:	26416732

129.
Journal:	Mol Imaging Biol. 2016 Apr;18(2):249-57.
Title:	The Synergistic Effect of Selumetinib/Docetaxel Combination Therapy Monitored by [(18)F]FDG/[(18)F]FLT PET and Diffusion-Weighted Magnetic Resonance Imaging in a Colorectal Tumor Xenograft Model.
Author:	Honndorf, Valerie S\|Schmidt, Holger\|Wiehr, Stefan\|Wehrl, Hans F\|Quintanilla-Martinez, Leticia\|Stahlschmidt, Anke\|Barjat, Herve\|Emmas, Sally-Ann\|Pichler, Bernd J
PMID:	26276154

130.
Journal:	Cancer Discov. 2016 Feb;6(2):147-153.
Title:	Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer.
Author:	Russo, Mariangela\|Siravegna, Giulia\|Blaszkowsky, Lawrence S\|Corti, Giorgio\|Crisafulli, Giovanni\|Ahronian, Leanne G\|Mussolin, Benedetta\|Kwak, Eunice L\|Buscarino, Michela\|Lazzari, Luca\|Valtorta, Emanuele\|Truini, Mauro\|Jessop, Nicholas A\|Robinson, Hayley E\|H
PMID:	26644315

131.
Journal:	Mol Cancer Res. 2016 Mar;14(3):296-301.
Title:	Identification of Targetable Kinase Alterations in Patients with Colorectal Carcinoma That are Preferentially Associated with Wild-Type RAS/RAF.
Author:	Hechtman, Jaclyn F\|Zehir, Ahmet\|Yaeger, Rona\|Wang, Lu\|Middha, Sumit\|Zheng, Tao\|Hyman, David M\|Solit, David\|Arcila, Maria E\|Borsu, Laetitia\|Shia, Jinru\|Vakiani, Efsevia\|Saltz, Leonard\|Ladanyi, Marc
PMID:	26660078

132.
Journal:	Invest New Drugs. 2016 Apr;34(2):168-75.
Title:	A phase I study of selumetinib (AZD6244/ARRY-142866), a MEK1/2 inhibitor, in combination with cetuximab in refractory solid tumors and KRAS mutant colorectal cancer.
Author:	Deming, Dustin A\|Cavalcante, Ludmila L\|Lubner, Sam J\|Mulkerin, Daniel L\|LoConte, Noelle K\|Eickhoff, Jens C\|Kolesar, Jill M\|Fioravanti, Suzanne\|Greten, Tim F\|Compton, Kathryn\|Doyle, Austin G\|Wilding, George\|Duffy, Austin\|Liu, Glenn
PMID:	26666244

133.
Journal:	J Transl Med. 2016 Jan 8;14:6.
Title:	Nanoproteomic analysis of ischemia-dependent changes in signaling protein phosphorylation in colorectal normal and cancer tissue.
Author:	Unger, Florian T\|Lange, Nicole\|Kruger, Jana\|Compton, Carolyn\|Moore, Helen\|Agrawal, Lokesh\|Juhl, Hartmut\|David, Kerstin A
PMID:	26742633

134.
Journal:	J Clin Pathol. 2016 Sep;69(9):767-71.
Title:	Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases.
Author:	Malapelle, Umberto\|Pisapia, Pasquale\|Sgariglia, Roberta\|Vigliar, Elena\|Biglietto, Maria\|Carlomagno, Chiara\|Giuffre, Giuseppe\|Bellevicine, Claudio\|Troncone, Giancarlo
PMID:	26797410

135.
Journal:	Cell Cycle. 2016;15(4):506-18.
Title:	Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.
Author:	Lochhead, Pamela A\|Clark, Jonathan\|Wang, Lan-Zhen\|Gilmour, Lesley\|Squires, Matthew\|Gilley, Rebecca\|Foxton, Caroline\|Newell, David R\|Wedge, Stephen R\|Cook, Simon J
PMID:	26959608

136.
Journal:	Cell Tissue Res. 2016 Aug;365(2):357-66.
Title:	Mesenchymal-epithelial signalling in tumour microenvironment: role of high-mobility group Box 1.
Author:	Sharma, Sikander\|Evans, Andrew\|Hemers, Elaine
PMID:	26979829

137.
Journal:	Mol Biol (Mosk). 2016 Jan-Feb;50(1):174-8.
Title:	[Alpha-1 Antitrypsin Affects U0126-Induced Cytotoxicity in Colon Cancer Cell Line (HCT116)].
Author:	Ljujic, M\|Mijatovic, S\|Bulatovic, M Z\|Mojic, M\|Maksimovic-Ivanic, D\|Radojkovic, D\|Topic, A
PMID:	27028823

138.
Journal:	J Cell Biochem. 2016 Dec;117(12):2854-2863.
Title:	The ERK1/2 and mTORC1 Signaling Pathways Are Involved in the Muscarinic Acetylcholine Receptor-Mediated Proliferation of SNU-407 Colon Cancer Cells.
Author:	Park, Yang-Seo\|Liu, Ziyu\|Vasamsetti, Bala Murali Krishna\|Cho, Nam Jeong
PMID:	27167250

139.
Journal:	Nat Commun. 2016 May 17;7:11551.
Title:	ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation.
Author:	de Jong, Petrus R\|Taniguchi, Koji\|Harris, Alexandra R\|Bertin, Samuel\|Takahashi, Naoki\|Duong, Jen\|Campos, Alejandro D\|Powis, Garth\|Corr, Maripat\|Karin, Michael\|Raz, Eyal
PMID:	27187615

140.
Journal:	Oncotarget. 2016 Jul 12;7(28):43442-43460.
Title:	Chemotherapy-related cachexia is associated with mitochondrial depletion and the activation of ERK1/2 and p38 MAPKs.
Author:	Barreto, Rafael\|Waning, David L\|Gao, Hongyu\|Liu, Yunlong\|Zimmers, Teresa A\|Bonetto, Andrea
PMID:	27259276

141.
Journal:	Cancer Res. 2016 Aug 1;76(15):4504-15.
Title:	Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer.
Author:	Oddo, Daniele\|Sennott, Erin M\|Barault, Ludovic\|Valtorta, Emanuele\|Arena, Sabrina\|Cassingena, Andrea\|Filiciotto, Genny\|Marzolla, Giulia\|Elez, Elena\|van Geel, Robin M J M\|Bartolini, Alice\|Crisafulli, Giovanni\|Boscaro, Valentina\|Godfrey, Jason T\|Buscarino, M
PMID:	27312529

142.
Journal:	Eur J Med Chem. 2016 Oct 21;122:611-618.
Title:	Autophagy regulates Selumetinib (AZD6244) induced-apoptosis in colorectal cancer cells.
Author:	Grasso, Silvina\|Pereira, Gustavo J S\|Palmeira-Dos-Santos, Caroline\|Calgarotto, Andrana K\|Martinez-Lacaci, Isabel\|Ferragut, Jose Antonio\|Smaili, Soraya S\|Bincoletto, Claudia
PMID:	27448918

143.
Journal:	Protein Cell. 2016 Aug;7(8):571-85.
Title:	Ursolic acid synergistically enhances the therapeutic effects of oxaliplatin in colorectal cancer.
Author:	Shan, Jianzhen\|Xuan, Yanyan\|Zhang, Qi\|Zhu, Chunpeng\|Liu, Zhen\|Zhang, Suzhan
PMID:	27472952

144.
Journal:	Med Oncol. 2016 Oct;33(10):106.
Title:	Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing.
Author:	Jauhri, Mayank\|Bhatnagar, Akanksha\|Gupta, Satish\|Shokeen, Yogender\|Minhas, Sachin\|Aggarwal, Shyam
PMID:	27568332

145.
Journal:	Oncologist. 2016 Nov;21(11):1306-1314.
Title:	Broad Detection of Alterations Predicted to Confer Lack of Benefit From EGFR Antibodies or Sensitivity to Targeted Therapy in Advanced Colorectal Cancer.
Author:	Rankin, Andrew\|Klempner, Samuel J\|Erlich, Rachel\|Sun, James X\|Grothey, Axel\|Fakih, Marwan\|George, Thomas J Jr\|Lee, Jeeyun\|Ross, Jeffrey S\|Stephens, Philip J\|Miller, Vincent A\|Ali, Siraj M\|Schrock, Alexa B
PMID:	27682134

146.
Journal:	Biochem Biophys Res Commun. 2016 Nov 18;480(3):450-454.
Title:	Muscarinic acetylcholine receptors mediate eIF4B phosphorylation in SNU-407 colon cancer cells.
Author:	Liu, Ziyu\|Cho, Nam Jeong
PMID:	27773818

147.
Journal:	Oncotarget. 2016 Dec 13;7(50):83017-83030.
Title:	PRIMA-1Met suppresses colorectal cancer independent of p53 by targeting MEK.
Author:	Lu, Tao\|Zou, Yanmei\|Xu, Guogang\|Potter, Jane A\|Taylor, Garry L\|Duan, Qiuhong\|Yang, Qin\|Xiong, Huihua\|Qiu, Hong\|Ye, Dawei\|Zhang, Peng\|Yu, Shiying\|Yuan, Xianglin\|Zhu, Feng\|Wang, Yihua\|Xiong, Hua
PMID:	27806324

148.
Journal:	BMC Cancer. 2016 Nov 14;16(1):882.
Title:	Leptin and insulin up-regulate miR-4443 to suppress NCOA1 and TRAF4, and decrease the invasiveness of human colon cancer cells.
Author:	Meerson, Ari\|Yehuda, Hila
PMID:	27842582

149.
Journal:	Gan To Kagaku Ryoho. 2016 Nov;43(12):1800-1802.
Title:	[A Case of Metastatic Colon Cancer Dramatically Affected by Anti-EGFR Antibody Therapy].
Author:	Yagi, Ryoma\|Shimada, Yoshifumi\|Miura, Kohei\|Tajima, Yosuke\|Okamura, Takuma\|Nakano, Masato\|Ichikawa, Hiroshi\|Nagahashi, Masayuki\|Sakata, Jun\|Kobayashi, Takashi\|Kameyama, Hitoshi\|Wakai, Toshifumi\|Nogami, Hitoshi\|Maruyama, Satoshi\|Takii, Yasumasa
PMID:	28133136

150.
Journal:	Oncogene. 2017 Jan 19;36(3):423-428.
Title:	Inhibition of the CRAF/prohibitin interaction reverses CRAF-dependent resistance to vemurafenib.
Author:	Doudican, N A\|Orlow, S J
PMID:	27321184

151.
Journal:	Oncogene. 2017 Feb 9;36(6):797-806.
Title:	Overproduction of IGF-2 drives a subset of colorectal cancer cells, which specifically respond to an anti-IGF therapeutic antibody and combination therapies.
Author:	Zhong, H\|Fazenbaker, C\|Chen, C\|Breen, S\|Huang, J\|Yao, X\|Ren, P\|Yao, Y\|Herbst, R\|Hollingsworth, R E
PMID:	27399333

152.
Journal:	Invest New Drugs. 2017 Feb;35(1):47-58.
Title:	A phase I dose-escalation study of TAK-733, an investigational oral MEK inhibitor, in patients with advanced solid tumors.
Author:	Adjei, Alex A\|LoRusso, Patricia\|Ribas, Antoni\|Sosman, Jeffrey A\|Pavlick, Anna\|Dy, Grace K\|Zhou, Xiaofei\|Gangolli, Esha\|Kneissl, Michelle\|Faucette, Stephanie\|Neuwirth, Rachel\|Bozon, Viviana
PMID:	27650277

153.
Journal:	J Cell Sci. 2017 Jan 1;130(1):203-218.
Title:	Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT-mTOR-S6K signaling and drug responses.
Author:	Riedl, Angelika\|Schlederer, Michaela\|Pudelko, Karoline\|Stadler, Mira\|Walter, Stefanie\|Unterleuthner, Daniela\|Unger, Christine\|Kramer, Nina\|Hengstschlager, Markus\|Kenner, Lukas\|Pfeiffer, Dagmar\|Krupitza, Georg\|Dolznig, Helmut
PMID:	27663511

154.
Journal:	Mol Cancer Ther. 2017 Feb;16(2):344-356.
Title:	Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities.
Author:	Talbert, Erin E\|Yang, Jennifer\|Mace, Thomas A\|Farren, Matthew R\|Farris, Alton B\|Young, Gregory S\|Elnaggar, Omar\|Che, Zheng\|Timmers, Cynthia D\|Rajasekera, Priyani\|Maskarinec, Jennifer M\|Bloomston, Mark\|Bekaii-Saab, Tanios\|Guttridge, Denis C\|Lesinski, Grego
PMID:	27811010

155.
Journal:	Br J Cancer. 2017 Feb 28;116(5):575-583.
Title:	A phase 1 dose-escalation and expansion study of binimetinib (MEK162), a potent and selective oral MEK1/2 inhibitor.
Author:	Bendell, Johanna C\|Javle, Milind\|Bekaii-Saab, Tanios S\|Finn, Richard S\|Wainberg, Zev A\|Laheru, Daniel A\|Weekes, Colin D\|Tan, Benjamin R\|Khan, Gazala N\|Zalupski, Mark M\|Infante, Jeffrey R\|Jones, Suzanne\|Papadopoulos, Kyriakos P\|Tolcher, Anthony W\|Chavira,
PMID:	28152546

156.
Journal:	J Nutr Biochem. 2017 May;43:11-17.
Title:	A food-based approach that targets interleukin-6, a key regulator of chronic intestinal inflammation and colon carcinogenesis.
Author:	Sido, Abigail\|Radhakrishnan, Sridhar\|Kim, Sung Woo\|Eriksson, Elisabeth\|Shen, Frank\|Li, Qunhua\|Bhat, Vadiraja\|Reddivari, Lavanya\|Vanamala, Jairam K P
PMID:	28193578

157.
Journal:	Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt A):1065-1074.
Title:	Glucose-derived AGEs promote migration and invasion of colorectal cancer by up-regulating Sp1 expression.
Author:	Deng, Ruyuan\|Wu, Huo\|Ran, Hui\|Kong, Xiang\|Hu, Lei\|Wang, Xiao\|Su, Qing
PMID:	28237576

158.
Journal:	Oncol Rep. 2017 Apr;37(4):2317-2323.
Title:	The anti-metastatic effect of baicalein on colorectal cancer.
Author:	Chai, Yuxia\|Xu, Jizhong\|Yan, Baojun
PMID:	28259937

159.
Journal:	J Biol Chem. 2017 Jun 16;292(24):10142-10152.
Title:	HMG-CoA synthase 1 is a synthetic lethal partner of BRAF(V600E) in human cancers.
Author:	Zhao, Liang\|Fan, Jun\|Xia, Siyuan\|Pan, Yaozhu\|Liu, Shuangping\|Qian, Guoqing\|Qian, Zhiyu\|Kang, Hee-Bum\|Arbiser, Jack L\|Pollack, Brian P\|Kudchadkar, Ragini R\|Lawson, David H\|Rossi, Michael\|Abdel-Wahab, Omar\|Merghoub, Taha\|Khoury, Hanna J\|Khuri, Fadlo R\|Boise
PMID:	28468827

160.
Journal:	Anticancer Res. 2017 Jun;37(6):2831-2838.
Title:	MEK162 Enhances Antitumor Activity of 5-Fluorouracil and Trifluridine in KRAS-mutated Human Colorectal Cancer Cell Lines.
Author:	Gong, Jun\|Chen, Yuan\|Yang, Lixin\|Pillai, Raju\|Shirasawa, Senji\|Fakih, Marwan
PMID:	28551618

161.
Journal:	JAMA Oncol. 2017 Nov 1;3(11):1546-1553.
Title:	Genomic Profiling of Small-Bowel Adenocarcinoma.
Author:	Schrock, Alexa B\|Devoe, Craig E\|McWilliams, Robert\|Sun, James\|Aparicio, Thomas\|Stephens, Philip J\|Ross, Jeffrey S\|Wilson, Richard\|Miller, Vincent A\|Ali, Siraj M\|Overman, Michael J
PMID:	28617917

162.
Journal:	Mol Cancer Res. 2017 Oct;15(10):1431-1444.
Title:	BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity.
Author:	Emery, Caroline M\|Monaco, Kelli-Ann\|Wang, Ping\|Balak, Marissa\|Freeman, Alyson\|Meltzer, Jodi\|Delach, Scott M\|Rakiec, Daniel\|Ruddy, David A\|Korn, Joshua M\|Haling, Jacob\|Acker, Michael G\|Caponigro, Giordano
PMID:	28655712

163.
Journal:	Chin J Cancer. 2017 Jul 31;36(1):63.
Title:	Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells.
Author:	Geng, Rong\|Tan, Xin\|Zuo, Zhixiang\|Wu, Jiangxue\|Pan, Zhizhong\|Shi, Wei\|Liu, Ranyi\|Yao, Chen\|Wang, Gaoyuan\|Lin, Jiaxin\|Qiu, Lin\|Huang, Wenlin\|Chen, Shuai
PMID:	28756770

164.
Journal:	J Cancer. 2017 Jul 20;8(12):2263-2268.
Title:	MAP2K1 Mutation in Colorectal Cancer Patients: Therapeutic Challenge Using Patient-Derived Tumor Cell Lines.
Author:	Kim, J E\|Kim, K K\|Kim, S Y\|Lee, J\|Park, S H\|Park, J O\|Park, Y S\|Lim, H Y\|Kang, W K\|Kim, S T
PMID:	28819429

165.
Journal:	Sci Rep. 2017 Sep 20;7(1):12020.
Title:	Ex vivo treatment of patient biopsies as a novel method to assess colorectal tumour response to the MEK1/2 inhibitor, Selumetinib.
Author:	Novo, Sonia M\|Wedge, Stephen R\|Stark, Lesley A
PMID:	28931905

166.
Journal:	Tumour Biol. 2017 Sep;39(9):1010428317724517.
Title:	EGFR pathway subgroups in Chilean colorectal cancer patients, detected by mutational and expression profiles, associated to different clinicopathological features.
Author:	Alvarez, Karin\|Orellana, Paulina\|Villarroel, Cynthia\|Contreras, Luis\|Kawachi, Hiroshi\|Kobayashi, Maki\|Wielandt, Ana Maria\|De la Fuente, Marjorie\|Trivino, Juan Carlos\|Kronberg, Udo\|Carvallo, Pilar\|Lopez-Kostner, Francisco
PMID:	28936923

167.
Journal:	Mol Syst Biol. 2017 Nov 3;13(11):951.
Title:	Pharmacoproteomic characterisation of human colon and rectal cancer.
Author:	Frejno, Martin\|Zenezini Chiozzi, Riccardo\|Wilhelm, Mathias\|Koch, Heiner\|Zheng, Runsheng\|Klaeger, Susan\|Ruprecht, Benjamin\|Meng, Chen\|Kramer, Karl\|Jarzab, Anna\|Heinzlmeir, Stephanie\|Johnstone, Elaine\|Domingo, Enric\|Kerr, David\|Jesinghaus, Moritz\|Slotta-Hus
PMID:	29101300

168.
Journal:	Oncotarget. 2017 Aug 2;8(47):82773-82783.
Title:	Antitumor efficacy of triple monoclonal antibody inhibition of epidermal growth factor receptor (EGFR) with MM151 in EGFR-dependent and in cetuximab-resistant human colorectal cancer cells.
Author:	Napolitano, Stefania\|Martini, Giulia\|Martinelli, Erika\|Della Corte, Carminia Maria\|Morgillo, Floriana\|Belli, Valentina\|Cardone, Claudia\|Matrone, Nunzia\|Ciardiello, Fortunato\|Troiani, Teresa
PMID:	29137301

169.
Journal:	Br J Cancer. 2018 Feb 20;118(4):558-565.
Title:	LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity.
Author:	Morgan, R G\|Mortensson, E\|Legge, D N\|Gupta, B\|Collard, T J\|Greenhough, A\|Williams, A C
PMID:	29149105

170.
Journal:	Mol Cell Proteomics. 2018 Apr;17(4):550-564.
Title:	Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells.
Author:	Basken, Joel\|Stuart, Scott A\|Kavran, Andrew J\|Lee, Thomas\|Ebmeier, Christopher C\|Old, William M\|Ahn, Natalie G
PMID:	29255136

171.
Journal:	Anticancer Res. 2018 Apr;38(4):2235-2240.
Title:	Racial Disparities in the Molecular Landscape of Cancer.
Author:	Heath, Elisabeth I\|Lynce, Filipa\|Xiu, Joanne\|Ellerbrock, Angela\|Reddy, Sandeep K\|Obeid, Elias\|Liu, Stephen V\|Bollig-Fischer, Aliccia\|Separovic, Duska\|Vanderwalde, Ari
PMID:	29599344

172.
Journal:	Oncotarget. 2018 Apr 17;9(29):20761-20768.
Title:	Clinical application of targeted next-generation sequencing for colorectal cancer patients: a multicentric Belgian experience.
Author:	D'Haene, Nicky\|Fontanges, Quitterie\|De Neve, Nancy\|Blanchard, Oriane\|Melendez, Barbara\|Delos, Monique\|Dehou, Marie-Francoise\|Maris, Calliope\|Nagy, Nathalie\|Rousseau, Emmanuel\|Vandenhove, Josse\|Gilles, Andre\|De Prez, Carine\|Verset, Laurine\|Van Craynest, Ma
PMID:	29755687

173.
Journal:	Mol Carcinog. 2018 Oct;57(10):1300-1310.
Title:	AKR1B10 activates diacylglycerol (DAG) second messenger in breast cancer cells.
Author:	Huang, Chenfei\|Cao, Zhe\|Ma, Jun\|Shen, Yi\|Bu, Yiwen\|Khoshaba, Ramina\|Shi, Guiyuan\|Huang, Dan\|Liao, Duan-Fang\|Ji, Haitao\|Jin, Junfei\|Cao, Deliang
PMID:	29846015

174.
Journal:	Cancer Res. 2018 Aug 15;78(16):4533-4548.
Title:	The Endosomal Protein CEMIP Links WNT Signaling to MEK1-ERK1/2 Activation in Selumetinib-Resistant Intestinal Organoids.
Author:	Duong, Hong Quan\|Nemazanyy, Ivan\|Rambow, Florian\|Tang, Seng Chuan\|Delaunay, Sylvain\|Tharun, Lars\|Florin, Alexandra\|Buttner, Reinhard\|Vandaele, Daniel\|Close, Pierre\|Marine, Jean-Christophe\|Shostak, Kateryna\|Chariot, Alain
PMID:	29915160

175.
Journal:	BMC Cancer. 2018 Aug 13;18(1):812.
Title:	Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment.
Author:	Tosi, Diego\|Perez-Gracia, Esther\|Atis, Salima\|Vie, Nadia\|Combes, Eve\|Gabanou, Melissa\|Larbouret, Christel\|Jarlier, Marta\|Mollevi, Caroline\|Torro, Adeline\|Del Rio, Maguy\|Martineau, Pierre\|Gongora, Celine
PMID:	30103709

176.
Journal:	Front Chem. 2018 Aug 23;6:373.
Title:	Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer.
Author:	Mioc, Marius\|Avram, Sorin\|Bercean, Vasile\|Kurunczi, Ludovic\|Ghiulai, Roxana M\|Oprean, Camelia\|Coricovac, Dorina E\|Dehelean, Cristina\|Mioc, Alexandra\|Balan-Porcarasu, Mihaela\|Tatu, Calin\|Soica, Codruta
PMID:	30234098

177.
Journal:	Mol Cancer Res. 2018 Oct 1. pii: 1541-7786.MCR-17-0554.
Title:	Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance.
Author:	Aronchik, Ida\|Dai, Yumin\|Labenski, Matt\|Barnes, Carmen\|Jones, Terri\|QIao, Lixin\|Beebe, Lisa\|Malek, Mehnaz\|Elis, Winfried\|Shi, Tao\|Mavrommatis, Konstantinos\|Bray, Gordon L\|Filvaroff, Ellen H
PMID:	30275173