Primary Site >> Pancreatic Cancer

Gene >> KRAS

Journal: Biochem Biophys Res Commun. 1985 Feb 28;127(1):168-74.
Title: Activation of the c-K-ras oncogene in a human pancreas carcinoma.
Author: Hirai, H|Okabe, T|Anraku, Y|Fujisawa, M|Urabe, A|Takaku, F
PMID: 3855240
Journal: Int J Pancreatol. 1986 Dec;1(5-6):299-308.
Title: Visualization of c-Ki-ras-2 oncogene sequences in human pancreas, a chemically induced transplantable carcinoma, and carcinomas of pancreas by in situ hybridization.
Author: Parsa, I|Cleary, C M|Marsh, W H|Butt, K M|Foye, C A
PMID: 3681029
Journal: Biochem Biophys Res Commun. 1986 Oct 15;140(1):167-73.
Title: Establishment of a human pancreatic adenocarcinoma cell line (PSN-1) with amplifications of both c-myc and activated c-Ki-ras by a point mutation.
Author: Yamada, H|Yoshida, T|Sakamoto, H|Terada, M|Sugimura, T
PMID: 3778442
Journal: Cell. 1988 May 20;53(4):549-54.
Title: Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes.
Author: Almoguera, C|Shibata, D|Forrester, K|Martin, J|Arnheim, N|Perucho, M
PMID: 2453289
Journal: Virchows Arch B Cell Pathol Incl Mol Pathol. 1988;55(6):355-61.
Title: Oncogene expression in endocrine pancreatic tumors.
Author: Hofler, H|Ruhri, C|Putz, B|Wirnsberger, G|Hauser, H
PMID: 2904191
Journal: Int J Pancreatol. 1988 Jan-Feb;3(1):45-51.
Title: Amplification of c-Ki-ras-2 oncogene sequences in human carcinoma of pancreas.
Author: Parsa, I|Pour, P M|Cleary, C M
PMID: 3280705
Journal: Jpn J Cancer Res. 1989 Jul;80(7):622-6.
Title: Frequency and types of point mutation at the 12th codon of the c-Ki-ras gene found in pancreatic cancers from Japanese patients.
Author: Mariyama, M|Kishi, K|Nakamura, K|Obata, H|Nishimura, S
PMID: 2507485
Journal: Baillieres Clin Gastroenterol. 1990 Mar;4(1):151-69.
Title: Mutational activation of the c-K-ras gene in human pancreatic carcinoma.
Author: Shibata, D|Capella, G|Perucho, M
PMID: 1976394
Journal: Mol Carcinog. 1990;3(6):379-86.
Title: Expression of c-myc, c-raf-1, and c-Ki-ras in azaserine-induced pancreatic carcinomas and growing pancreas in rats.
Author: Silverman, J A|Kuhlmann, E T|Zurlo, J|Yager, J D|Longnecker, D S
PMID: 2278633
Journal: Nihon Shokakibyo Gakkai Zasshi. 1991 Nov;88(11):2795-803.
Title: [Point mutation of c-k-ras oncogene at codon 12 in mucin-producing cystic tumor of the pancreas].
Author: Satoh, K|Sawai, T|Shimosegawa, T|Koizumi, M|Yamazaki, T|Mochizuki, F|Toyota, T
PMID: 1662731
Journal: Genes Chromosomes Cancer. 1991 Nov;3(6):468-73.
Title: Evidence for a common molecular pathogenesis in colorectal, gastric, and pancreatic cancer.
Author: Neuman, W L|Wasylyshyn, M L|Jacoby, R|Erroi, F|Angriman, I|Montag, A|Brasitus, T|Michelassi, F|Westbrook, C A
PMID: 1663781
Journal: J Formos Med Assoc. 1991 Dec;90(12):1149-54.
Title: Analysis of ras gene mutations in gastrointestinal cancers.
Author: Shen, C|Chang, J G|Lee, L S|Yang, M J|Chen, T C|Lin, K Y|Lee, M D|Chen, P H
PMID: 1686883
Journal: Environ Health Perspect. 1991 Jun;93:27-31.
Title: Frequency and spectrum of c-Ki-ras mutations in human sporadic colon carcinoma, carcinomas arising in ulcerative colitis, and pancreatic adenocarcinoma.
Author: Burmer, G C|Rabinovitch, P S|Loeb, L A
PMID: 1773797
Journal: Carcinogenesis. 1991 Aug;12(8):1477-82.
Title: Activation of c-K-ras is frequent in pancreatic carcinomas of Syrian hamsters, but is absent in pancreatic tumors of rats.
Author: van Kranen, H J|Vermeulen, E|Schoren, L|Bax, J|Woutersen, R A|van Iersel, P|van Kreijl, C F|Scherer, E
PMID: 1860169
Journal: Nihon Geka Gakkai Zasshi. 1991 Apr;92(4):453-8.
Title: [Detection of point mutation of Kirsten ras oncogene in pancreatic carcinoma by polymerase chain reaction].
Author: Motojima, K|Kohara, N|Furui, J|Terada, M|Tsunoda, T|Nagata, Y|Urano, K
PMID: 1870574
Journal: Jpn J Cancer Res. 1991 Oct;82(10):1057-60.
Title: c-Ki-ras point mutations in ductectatic-type mucinous cystic neoplasms of the pancreas.
Author: Yanagisawa, A|Kato, Y|Ohtake, K|Kitagawa, T|Ohashi, K|Hori, M|Takagi, K|Sugano, H
PMID: 1955373
Journal: Yale J Biol Med. 1992 Sep-Oct;65(5):457-64; discussion 465-9.
Title: Recent results in animal models of pancreatic carcinoma: histogenesis of tumors.
Author: Longnecker, D S|Memoli, V|Pettengill, O S
PMID: 1340063
Journal: Zhonghua Zhong Liu Za Zhi. 1992 Jan;14(1):30-2.
Title: [Expression of c-myc and c-ki-ras oncogene in human pancreatic carcinoma].
Author: Li, D C
PMID: 1396043
Journal: Anticancer Res. 1992 Sep-Oct;12(5):1731-5.
Title: Detection of K-ras mutations by denaturing gradient gel electrophoresis (DGGE): a study on pancreatic cancer.
Author: Pellegata, N S|Losekoot, M|Fodde, R|Pugliese, V|Saccomanno, S|Renault, B|Bernini, L F|Ranzani, G N
PMID: 1444240
Journal: J Natl Cancer Inst. 1993 Dec 15;85(24):2008-12.
Title: Detection of c-Ki-ras mutation by PCR/RFLP analysis and diagnosis of pancreatic adenocarcinomas.
Author: Urban, T|Ricci, S|Grange, J D|Lacave, R|Boudghene, F|Breittmayer, F|Languille, O|Roland, J|Bernaudin, J F
PMID: 7902444
Journal: Carcinogenesis. 1993 May;14(5):1027-33.
Title: Neoplastic transformation of propagable cultured rat pancreatic duct epithelial cells by azaserine and streptozotocin.
Author: Shepherd, J G|Chen, J R|Tsao, M S|Duguid, W P
PMID: 8099312
Journal: Am J Clin Pathol. 1993 Dec;100(6):686-9.
Title: Mutation analysis of K-ras oncogenes in gastroenterologic cancers by the amplified created restriction sites method.
Author: Lin, S Y|Chen, P H|Wang, C K|Liu, J D|Siauw, C P|Chen, Y J|Yang, M J|Liu, M H|Chen, T C|Chang, J G
PMID: 8249918
Journal: Rinsho Byori. 1993 Sep;41(9):1017-23.
Title: [Sensitive detection of K-ras oncogene codon 12 mutations by nested PCR using mismatched primers and selective digestion of non-mutated PCR fragments with restriction enzyme].
Author: Fukayama, N|Sugano, K|Kyogoku, A|Nose, H|Kondou, H|Ohkura, H
PMID: 8254964
Journal: Int J Pancreatol. 1993 Oct;14(2):135-43.
Title: The point mutation of c-Ki-ras at codon 12 in carcinoma of the pancreatic head region and in intraductal mucin-hypersecreting neoplasm of the pancreas.
Author: Satoh, K|Sawai, T|Shimosegawa, T|Koizumi, M|Yamazaki, T|Mochizuki, F|Toyota, T
PMID: 8283077
Journal: Br J Cancer. 1993 Feb;67(2):279-83.
Title: Inhibition of human pancreatic cancer cell (MIA PaCa-2) growth by cholera toxin and 8-chloro-cAMP in vitro.
Author: Ohmura, E|Wakai, K|Isozaki, O|Murakami, H|Onoda, N|Emoto, N|Shizume, K|Tsushima, T|Demura, H|Robins, R K
PMID: 8381655
Journal: Jpn J Cancer Res. 1993 Sep;84(9):961-5.
Title: Identification of K-ras oncogene mutations in the pure pancreatic juice of patients with ductal pancreatic cancers.
Author: Watanabe, H|Sawabu, N|Ohta, H|Satomura, Y|Yamakawa, O|Motoo, Y|Okai, T|Takahashi, H|Wakabayashi, T
PMID: 8407563
Journal: Oncogene. 1993 Feb;8(2):289-98.
Title: p53 and K-RAS alterations in pancreatic epithelial cell lesions.
Author: Kalthoff, H|Schmiegel, W|Roeder, C|Kasche, D|Schmidt, A|Lauer, G|Thiele, H G|Honold, G|Pantel, K|Riethmuller, G
PMID: 8426738
Journal: Cancer Res. 1993 Jun 1;53(11):2472-4.
Title: Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma.
Author: Tada, M|Omata, M|Kawai, S|Saisho, H|Ohto, M|Saiki, R K|Sninsky, J J
PMID: 8495407
Journal: Int J Oncol. 1993 Oct;3(4):641-4.
Title: Possible association of nm23 gene-expression and ki-ras point mutations with metastatic potential in human pancreatic cancer-derived cell-lines.
Author: Yasuda, D|Iguchi, H|Ikeda, Y|Nishimura, S|Steeg, P|Misawa, T|Nawata, H|Kono, A
PMID: 21573412
Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1994 Jun;16(3):201-5.
Title: [Point mutation at codon 12 of c-Ki-ras oncogene in human pancreatic neoplasms and normal human pancreas tissue].
Author: Cui, Q|Wang, Z|Chen, J
PMID: 7805165
Journal: Pancreas. 1994 Sep;9(5):657-61.
Title: Lovastatin inhibits pancreatic cancer growth regardless of RAS mutation.
Author: Sumi, S|Beauchamp, R D|Townsend, C M Jr|Pour, P M|Ishizuka, J|Thompson, J C
PMID: 7809022
Journal: J Clin Pathol. 1994 Dec;47(12):1082-4.
Title: Diagnosis of pancreatic lesions using fine needle aspiration cytology: detection of K-ras point mutations using solid phase minisequencing.
Author: Ihalainen, J|Taavitsainen, M|Salmivaara, T|Palotie, A
PMID: 7876379
Journal: J Natl Cancer Inst. 1994 Oct 19;86(20):1547-9.
Title: Ki-ras mutations in pancreatic secretions and aspirates from two patients without pancreatic cancer.
Author: Suzuki, H|Yoshida, S|Ichikawa, Y|Yokota, H|Mutoh, H|Koyama, A|Fukazawa, M|Todoroki, T|Fukao, K|Uchida, K
PMID: 7932811
Journal: Zentralbl Pathol. 1994 Aug;140(3):203-10.
Title: [Lesions of the pancreatic duct epithelium and histogenesis of exocrine pancreatic carcinomas].
Author: Schulz, H J
PMID: 7947629
Journal: Tidsskr Nor Laegeforen. 1994 Oct 30;114(26):3079-81.
Title: [Analysis of Ki-ras in pancreatic fluid aspirate. A new diagnostic possibility in investigation of pancreatic cancer].
Author: Ogreid, D|Ulvik, A|Horn, A|Sondenaa, K
PMID: 7974428
Journal: Cancer Res. 1994 Jul 1;54(13):3568-73.
Title: Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia.
Author: Caldas, C|Hahn, S A|Hruban, R H|Redston, M S|Yeo, C J|Kern, S E
PMID: 8012983
Journal: Int J Cancer. 1994 Jul 15;58(2):185-91.
Title: Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer.
Author: Berrozpe, G|Schaeffer, J|Peinado, M A|Real, F X|Perucho, M
PMID: 8026879
Journal: Mol Carcinog. 1994 Jun;10(2):110-4.
Title: Only wild-type c-Ki-ras codons 12, 13, and 61 in human pancreatic acinar cell carcinomas.
Author: Terhune, P G|Heffess, C S|Longnecker, D S
PMID: 8031464
Journal: Jpn J Cancer Res. 1994 Jun;85(6):633-8.
Title: Cytotoxicity of simvastatin to pancreatic adenocarcinoma cells containing mutant ras gene.
Author: Ura, H|Obara, T|Nishino, N|Tanno, S|Okamura, K|Namiki, M
PMID: 8063617
Journal: Zhonghua Yi Xue Za Zhi. 1994 Feb;74(2):77-9, 125-6.
Title: [Point mutation of K-ras gene in pancreatic carcinoma].
Author: Huang, Y T|Yang, Y M|Liu, Q
PMID: 8069725
Journal: Cancer Epidemiol Biomarkers Prev. 1994 Jan-Feb;3(1):67-71.
Title: Soluble normal and mutated DNA sequences from single-copy genes in human blood.
Author: Sorenson, G D|Pribish, D M|Valone, F H|Memoli, V A|Bzik, D J|Yao, S L
PMID: 8118388
Journal: Cancer. 1994 Mar 15;73(6):1589-94.
Title: Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma.
Author: Kondo, H|Sugano, K|Fukayama, N|Kyogoku, A|Nose, H|Shimada, K|Ohkura, H|Ohtsu, A|Yoshida, S|Shimosato, Y
PMID: 8156485
Journal: Int J Cancer. 1994 Apr 15;57(2):167-71.
Title: Pancreatic cancer in Europe: Ki-ras gene mutation pattern shows geographical differences.
Author: Scarpa, A|Capelli, P|Villaneuva, A|Zamboni, G|Lluis, F|Accolla, R|Mariuzzi, G|Capella, G
PMID: 8157353
Journal: Am J Pathol. 1994 May;144(5):889-95.
Title: Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma.
Author: DiGiuseppe, J A|Hruban, R H|Offerhaus, G J|Clement, M J|van den Berg, F M|Cameron, J L|van Mansfeld, A D
PMID: 8178941
Journal: Cancer Lett. 1995 Nov 6;97(2):203-11.
Title: Peritoneal exfoliative cytology and Ki-ras mutational analysis in patients with pancreatic adenocarcinoma.
Author: Rall, C J|Rivera, J A|Centeno, B A|Fernandez-del Castillo, C|Rattner, D W|Warshaw, A L|Rustgi, A K
PMID: 7497464
Journal: Jpn J Cancer Res. 1995 Jul;86(7):626-30.
Title: Detection of hepatic micrometastasis in pancreatic adenocarcinoma patients by two-stage polymerase chain reaction/restriction fragment length polymorphism analysis.
Author: Inoue, S|Nakao, A|Kasai, Y|Harada, A|Nonami, T|Takagi, H
PMID: 7559078
Journal: Ann Intern Med. 1995 Aug 1;123(3):188-91.
Title: Identification of K-ras mutations in pancreatic juice in the early diagnosis of pancreatic cancer.
Author: Berthelemy, P|Bouisson, M|Escourrou, J|Vaysse, N|Rumeau, J L|Pradayrol, L
PMID: 7598300
Journal: Cancer Res. 1995 Sep 1;55(17):3810-6.
Title: Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity.
Author: Aoki, K|Yoshida, T|Sugimura, T|Terada, M
PMID: 7641198
Journal: Nihon Rinsho. 1995 Feb;53(2):511-7.
Title: [Mutation of the K-ras oncogene in pancreatic carcinoma, and application of its detection in pancreatic juice to diagnose pancreatic carcinoma].
Author: Sawabu, N|Watanabe, H|Yamaguchi, Y|Okai, T
PMID: 7699881
Journal: J Clin Pathol. 1995 Mar;48(3):218-22.
Title: Molecular markers for diagnostic cytology of neoplasms in the head region of the pancreas: mutation of K-ras and overexpression of the p53 protein product.
Author: van Es, J M|Polak, M M|van den Berg, F M|Ramsoekh, T B|Craanen, M E|Hruban, R H|Offerhaus, G J
PMID: 7730480
Journal: Dtsch Med Wochenschr. 1995 Jun 9;120(23):821-5.
Title: [Ki-ras mutation as a molecular tumor marker for carcinoma of the pancreas].
Author: Daus, H|Trumper, L|Burger, B|Jacobs, G|Kriener, S|von Blohn, G|Zeitz, M|Pfreundschuh, M
PMID: 7781522
Journal: Dtsch Med Wochenschr. 1995 Jun 9;120(23):830-3.
Title: [Ki-ras mutation--a specific and sensitive tumor marker for carcinoma of the pancreas?].
Author: Schmid, R M|Adler, G
PMID: 7781524
Journal: Gut. 1995 May;36(5):781-7.
Title: Detection of c-Ki-ras gene codon 12 mutations from pancreatic duct brushings in the diagnosis of pancreatic tumours.
Author: Van Laethem, J L|Vertongen, P|Deviere, J|Van Rampelbergh, J|Rickaert, F|Cremer, M|Robberecht, P
PMID: 7797131
Journal: Mutat Res. 1995 Mar;327(1-2):151-60.
Title: Absence of Ki-ras mutations in exocrine pancreatic tumors from male rats chronically exposed to gabapentin.
Author: Fowler, M L|Sigler, R E|de la Iglesia, F A|Reddy, J K|Lalwani, N D
PMID: 7870083
Journal: Int J Pancreatol. 1995 Oct;18(2):169-75.
Title: Mixed pleomorphic-osteoclast-like tumor of the pancreas. Light microscopical, immunohistochemical, and molecular biological studies.
Author: Gatteschi, B|Saccomanno, S|Bartoli, F G|Salvi, S|Liu, G|Pugliese, V
PMID: 8530833
Journal: Int J Pancreatol. 1995 Dec;18(3):215-20.
Title: Detection of point mutations in K-ras gene at codon 12 in bile from percutaneous transhepatic choledochal drainage tubes for diagnosis of biliary strictures.
Author: Ajiki, T|Onoyama, H|Yamamoto, M|Fujimori, T|Maeda, S|Saitoh, Y
PMID: 8708392
Journal: Zhonghua Bing Li Xue Za Zhi. 1995 Oct;24(5):288-91.
Title: [Reversal of malignant cell phenotype of human pancreatic adenocarcinoma cell line by recombinant retroviral vector expressing antisense Ki-ras].
Author: Li, H|Wang, Z|Liu, T
PMID: 8745475
Journal: Clin Mol Pathol. 1995 Dec;48(6):M316-8.
Title: Detection of c-Ki-ras mutations in bile samples from patients with pancreatic and biliary cancers.
Author: O'mahony, S|Longfellow, M|McMahon, M J|Axon, A T|Quirke, P
PMID: 16696030
Journal: Int J Oncol. 1995 May;6(5):1105-12.
Title: Effects of antisense oligonucleotides targeting k-ras expression in pancreatic-cancer cell-lines.
Author: Carter, G|Gilbert, C|Lemoine, N
PMID: 21556647
Journal: Gastroenterology. 1996 Jan;110(1):221-6.
Title: Analysis of Ki-ras codon 12 mutations in the duodenal juice of patients with pancreatic cancer.
Author: Iguchi, H|Sugano, K|Fukayama, N|Ohkura, H|Sadamoto, K|Ohkoshi, K|Seo, Y|Tomoda, H|Funakoshi, A|Wakasugi, H
PMID: 8536860
Journal: Gastroenterology. 1996 Jan;110(1):227-31.
Title: Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease.
Author: Tada, M|Ohashi, M|Shiratori, Y|Okudaira, T|Komatsu, Y|Kawabe, T|Yoshida, H|Machinami, R|Kishi, K|Omata, M
PMID: 8536861
Journal: Gastroenterology. 1996 Jan;110(1):311-2; discussion 312-3.
Title: ERCP meets C-K-ras: towards an improved diagnosis of pancreatic cancer.
Author: Pasricha, P J
PMID: 8536877
Journal: Lab Invest. 1996 Jan;74(1):279-89.
Title: p53, Ki-ras, and DNA ploidy in human pancreatic ductal adenocarcinomas.
Author: Weyrer, K|Feichtinger, H|Haun, M|Weiss, G|Ofner, D|Weger, A R|Umlauft, F|Grunewald, K
PMID: 8569192
Journal: Am J Clin Pathol. 1996 Mar;105(3):321-6.
Title: Polymerase chain reaction-based K-ras mutation detection of pancreatic adenocarcinoma in routine cytology smears.
Author: Apple, S K|Hecht, J R|Novak, J M|Nieberg, R K|Rosenthal, D L|Grody, W W
PMID: 8602613
Journal: Jpn J Cancer Res. 1996 Feb;87(2):113-6.
Title: Suppression of human pancreatic cancer growth in BALB/c nude mice by manumycin, a farnesyl:protein transferase inhibitor.
Author: Ito, T|Kawata, S|Tamura, S|Igura, T|Nagase, T|Miyagawa, J I|Yamazaki, E|Ishiguro, H|Matasuzawa, Y
PMID: 8609057
Journal: Gastroenterology. 1996 May;110(5):1587-94.
Title: Diagnostic utility of K-ras mutations in fine-needle aspirates of pancreatic masses.
Author: Villanueva, A|Reyes, G|Cuatrecasas, M|Martinez, A|Erill, N|Lerma, E|Farre, A|Lluis, F|Capella, G
PMID: 8613066
Journal: Carcinogenesis. 1996 Feb;17(2):303-9.
Title: High yields of K-ras mutations in intraductal papillary mucinous tumors and invasive adenocarcinomas induced by N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine in the pancreas of female Syrian hamsters.
Author: Sugio, K|Gazdar, A F|Albores-Saavedra, J|Kokkinakis, D M
PMID: 8625455
Journal: Jpn J Cancer Res. 1996 May;87(5):466-74.
Title: Detection of K-ras point mutations at codon 12 in pancreatic juice for the diagnosis of pancreatic cancer by hybridization protection assay: a simple method for the determination of the types of point mutation.
Author: Watanabe, H|Miyagi, C|Yamaguchi, Y|Satomura, Y|Ohta, H|Motoo, Y|Okai, T|Yoshimura, T|Tsuji, Y|Sawabu, N
PMID: 8641983
Journal: Nihon Rinsho. 1996 Jun;54(6):1587-91.
Title: [Sensitivity and specificity of tumor markers in cancer diagnosis].
Author: Motoo, Y|Watanabe, H|Sawabu, N
PMID: 8691613
Journal: Ann Surg Oncol. 1996 May;3(3):241-6.
Title: Molecular diagnosis of exocrine pancreatic cancer using a percutaneous technique.
Author: Evans, D B|Frazier, M L|Charnsangavej, C|Katz, R L|Larry, L|Abbruzzese, J L
PMID: 8726178
Journal: Pancreas. 1996 May;12(4):362-8.
Title: K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas.
Author: Satoh, K|Shimosegawa, T|Moriizumi, S|Koizumi, M|Toyota, T
PMID: 8740403
Journal: Am J Gastroenterol. 1996 Aug;91(8):1616-21.
Title: Diagnosis of pancreatic cancer by K-ras point mutation and cytology of pancreatic juice.
Author: Uehara, H|Nakaizumi, A|Baba, M|Iishi, H|Tatsuta, M|Kitamura, T|Ohigashi, H|Ishikawa, O|Takenaka, A|Ishiguro, S
PMID: 8759672
Journal: Int J Cancer. 1996 Jul 17;67(2):264-8.
Title: An effect of K-ras gene mutation on epidermal growth factor receptor signal transduction in PANC-1 pancreatic carcinoma cells.
Author: Watanabe, M|Nobuta, A|Tanaka, J|Asaka, M
PMID: 8760597
Journal: J Clin Pathol. 1996 Jun;49(6):460-4.
Title: Clinical significance of K-ras oncogene activation in ampullary neoplasms.
Author: Chung, C H|Wilentz, R E|Polak, M M|Ramsoekh, T B|Noorduyn, L A|Gouma, D J|Huibregtse, K|Offerhaus, G J|Slebos, R J
PMID: 8763258
Journal: Jpn J Cancer Res. 1996 Aug;87(8):793-7.
Title: Detection of ras gene mutations in perioperative peripheral blood with pancreatic adenocarcinoma.
Author: Nomoto, S|Nakao, A|Kasai, Y|Harada, A|Nonami, T|Takagi, H
PMID: 8797884
Journal: Tohoku J Exp Med. 1996 Apr;178(4):437-45.
Title: Double cancer in a 74-year-old woman: a case report with genetic findings.
Author: Katada, F|Murakami, K|Uzuki, M|Horii, A
PMID: 8804161
Journal: Gan To Kagaku Ryoho. 1996 Oct;23(12):1657-9.
Title: [Growth inhibition of human pancreatic cancer by farnesyl transferase inhibitor].
Author: Kainuma, O|Asano, T|Hasegawa, M|Isono, K
PMID: 8886038
Journal: Recent Results Cancer Res. 1996;142:63-71.
Title: Signal transduction as target of gene therapy.
Author: Moelling, K|Strack, B|Radziwill, G
PMID: 8893335
Journal: Pancreas. 1996 Jan;12(1):10-7.
Title: Ki-ras and p53 mutations in pancreatic ductal adenocarcinoma.
Author: Rall, C J|Yan, Y X|Graeme-Cook, F|Beauchamp, R|Yandell, D W|Povoski, S P|Rustgi, A K
PMID: 8927612
Journal: Int J Pancreatol. 1996 Oct;20(2):85-93.
Title: Clinicopathological significance of Ki-ras point mutation and p21 expression in benign and malignant exocrine tumors of the human pancreas.
Author: Song, M M|Nio, Y|Sato, Y|Tamura, K|Furuse, K
PMID: 8968863
Journal: Cancer Res. 1996 Dec 15;56(24):5713-9.
Title: Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice.
Author: Reyes, G|Villanueva, A|Garcia, C|Sancho, F J|Piulats, J|Lluis, F|Capella, G
PMID: 8971180
Journal: Int J Radiat Oncol Biol Phys. 1996 Jan 1;34(1):161-6.
Title: C-Ki-ras mutations in peripheral blood of pancreatic cancer patients: a marker for early tumor metastasis.
Author: Mohiuddin, M|Ahmed, M M|Venkatasubbarao, K
PMID: 12118546
Journal: Surgery. 1997 Jan;121(1):42-9.
Title: Analysis of K-ras oncogene mutations in chronic pancreatitis with ductal hyperplasia.
Author: Rivera, J A|Rall, C J|Graeme-Cook, F|Fernandez-del Castillo, C|Shu, P|Lakey, N|Tepper, R|Rattner, D W|Warshaw, A L|Rustgi, A K
PMID: 9001550
Journal: Hum Pathol. 1997 Jan;28(1):80-3.
Title: KRAS oncogene mutations suggest a common histogenetic origin for pleomorphic giant cell tumor of the pancreas, osteoclastoma of the pancreas, and pancreatic duct adenocarcinoma.
Author: Gocke, C D|Dabbs, D J|Benko, F A|Silverman, J F
PMID: 9013836
Journal: Cancer. 1997 Mar 1;79(5):900-5.
Title: Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas.
Author: Kondo, H|Sugano, K|Fukayama, N|Hosokawa, K|Ohkura, H|Ohtsu, A|Mukai, K|Yoshida, S
PMID: 9041151
Journal: J Surg Oncol. 1997 Feb;64(2):159-62.
Title: Adenosquamous carcinoma arising in a mucinous cystadenoma of the pancreas.
Author: Campman, S C|Fajardo, M A|Rippon, M B|Kraegel, S A|Ruebner, B H
PMID: 9047255
Journal: Biochem Biophys Res Commun. 1997 Feb 24;231(3):705-11.
Title: Overexpression of SAP-1, a transmembrane-type protein tyrosine phosphatase, in human colorectal cancers.
Author: Seo, Y|Matozaki, T|Tsuda, M|Hayashi, Y|Itoh, H|Kasuga, M
PMID: 9070877
Journal: Int J Cancer. 1997 Mar 17;70(6):661-7.
Title: Ki-ras mutations in exocrine pancreatic cancer: association with clinico-pathological characteristics and with tobacco and alcohol consumption. PANK-ras I Project Investigators.
Author: Malats, N|Porta, M|Corominas, J M|Pinol, J L|Rifa, J|Real, F X
PMID: 9096646
Journal: Acta Cytol. 1997 Mar-Apr;41(2):427-34.
Title: Ki-ras mutations and the carcinoembryonic antigen level in fine needle aspirates of the pancreas.
Author: Pinto, M M|Emanuel, J R|Chaturvedi, V|Costa, J
PMID: 9100777
Journal: Int J Pancreatol. 1997 Feb;21(1):85-90.
Title: Sclerosing pancreatitis showing rapidly progressive changes with recurrent mass formation.
Author: Motoo, Y|Minamoto, T|Watanabe, H|Sakai, J|Okai, T|Sawabu, N
PMID: 9127178
Journal: Cancer Res. 1997 May 1;57(9):1731-4.
Title: Tumor-suppressive pathways in pancreatic carcinoma.
Author: Rozenblum, E|Schutte, M|Goggins, M|Hahn, S A|Panzer, S|Zahurak, M|Goodman, S N|Sohn, T A|Hruban, R H|Yeo, C J|Kern, S E
PMID: 9135016
Journal: Anticancer Res. 1997 Mar-Apr;17(2A):795-801.
Title: Detection of mutated c-Ki-ras in the bile of patients with pancreatic cancer.
Author: Abbruzzese, J L|Evans, D B|Raijman, I|Larry, L|King, T|Leach, S D|Frazier, M L
PMID: 9137410
Journal: Cancer Res. 1997 Jun 1;57(11):2140-3.
Title: p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.
Author: Moskaluk, C A|Hruban, R H|Kern, S E
PMID: 9187111
Journal: J Surg Res. 1997 Apr;69(1):199-204.
Title: Activation of Raf-1 in human pancreatic adenocarcinoma.
Author: Berger, D H|Jardines, L A|Chang, H|Ruggeri, B
PMID: 9202670
Journal: Int J Pancreatol. 1997 Apr;21(2):127-43.
Title: Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma.
Author: Dergham, S T|Dugan, M C|Kucway, R|Du, W|Kamarauskiene, D S|Vaitkevicius, V K|Crissman, J D|Sarkar, F H
PMID: 9209954
Journal: J Clin Lab Anal. 1997;11(4):225-31.
Title: Molecular diagnosis of pancreas carcinoma.
Author: Chu, T M
PMID: 9219065
Journal: Nihon Geka Gakkai Zasshi. 1997 Jul;98(7):597-603.
Title: [Molecular diagnosis of pancreatic cancer].
Author: Sugano, K
PMID: 9276865
Journal: Nihon Geka Gakkai Zasshi. 1997 Jul;98(7):639-45.
Title: [Newly-developing therapies of pancreatic cancer--immunotherapy, gene therapy, differentiation therapy, endocrine therapy and others].
Author: Nio, Y|Tamura, K
PMID: 9276872
Journal: Surg Endosc. 1997 Sep;11(9):902-6.
Title: The incidence of port-site metastases might be reduced.
Author: Reymond, M A|Wittekind, C|Jung, A|Hohenberger, W|Kirchner, T|Kockerling, F
PMID: 9294269
Journal: Int J Pancreatol. 1997 Jun;21(3):225-34.
Title: Relationship of family cancer history to the expression of p53, p21WAF-1, HER-2/neu, and K-ras mutation in pancreatic adenocarcinoma.
Author: Dergham, S T|Dugan, M C|Arlauskas, P|Du, W|Vaitkevicius, V K|Crissman, J D|Sarkar, F H
PMID: 9322121
Journal: Ann Surg. 1997 Oct;226(4):491-8; discussion 498-500.
Title: Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas.
Author: Z'graggen, K|Rivera, J A|Compton, C C|Pins, M|Werner, J|Fernandez-del Castillo, C|Rattner, D W|Lewandrowski, K B|Rustgi, A K|Warshaw, A L
PMID: 9351717
Journal: Mol Carcinog. 1997 Oct;20(2):251-8.
Title: Suppression of Ki-ras p21 levels leading to growth inhibition of pancreatic cancer cell lines with Ki-ras mutation but not those without Ki-ras mutation.
Author: Aoki, K|Yoshida, T|Matsumoto, N|Ide, H|Sugimura, T|Terada, M
PMID: 9364215
Journal: Surg Oncol. 1997;6(1):1-18.
Title: The molecular genetics of pancreatic cancer.
Author: Howe, J R|Conlon, K C
PMID: 9364657
Journal: Ciba Found Symp. 1997;209:124-37; discussion 137-41.
Title: Differential oligonucleotide activity in cell culture versus mouse models.
Author: Wickstrom, E|Tyson, F L
PMID: 9383573
Journal: Jpn J Cancer Res. 1997 Oct;88(10):971-6.
Title: Increased telomerase activities in human pancreatic duct adenocarcinomas.
Author: Tsutsumi, M|Tsujiuchi, T|Ishikawa, O|Majima, T|Yoshimoto, M|Sasaki, Y|Fukuda, T|Oohigashi, H|Konishi, Y
PMID: 9414659
Journal: Digestion. 1997;58(6):550-6.
Title: Molecular advances in pancreatic cancer.
Author: Lemoine, N R
PMID: 9438601
Journal: Langenbecks Arch Chir Suppl Kongressbd. 1997;114:379-82.
Title: [Instrumental diagnosis for therapy decision making--what is possible and desirable, what is indispensible and what is superfluous in tumors of the pancreas?].
Author: Kremer, B|Henne-Bruns, D|Grimm, H
PMID: 9574160
Journal: Vnitr Lek. 1997 Oct;43(10):678-81.
Title: [Detection of the Ki-ras mutation as a specific and sensitive marker of pancreatic carcinoma].
Author: Krechler, T|Janda, J|Dufek, V|Kalab, M|Peskova, M|Dorazilova, V
PMID: 9601883
Journal: Zhonghua Bing Li Xue Za Zhi. 1997 Jun;26(3):147-51.
Title: [Inhibition of cell growth and target gene expression of human pancreatic carcinoma cells by modified antisense oligodeoxynucleotide].
Author: Liu, T|Wang, Z|Zhang, L
PMID: 10072855
Journal: Zhonghua Bing Li Xue Za Zhi. 1997 Oct;26(5):281-4.
Title: [The inhibitory effect of combined treatment of TNF alpha and antisense oligodeoxynucleotides on the growth of human pancreatic carcinoma cell line cells].
Author: Zhang, L|Guo, H|Liu, T
PMID: 10374336
Journal: Oncol Rep. 1997 Nov-Dec;4(6):1373-81.
Title: Analysis of K-ras gene mutations in human pancreatic cancer cell lines and in bile samples from patients with pancreatic and biliary cancers.
Author: Evans, T|Faircloth, M|Deery, A|Thomas, V|Turner, A|Dalgleish, A
PMID: 21590256
Journal: Cancer. 1998 Jan 1;82(1):96-103.
Title: K-ras mutations in the duodenal fluid of patients with pancreatic carcinoma.
Author: Wilentz, R E|Chung, C H|Sturm, P D|Musler, A|Sohn, T A|Offerhaus, G J|Yeo, C J|Hruban, R H|Slebos, R J
PMID: 9428484
Journal: Surg Oncol Clin N Am. 1998 Jan;7(1):25-41.
Title: Role of growth factors in pancreatic cancer.
Author: Korc, M
PMID: 9443985
Journal: Br J Cancer. 1998;77(1):147-52.
Title: Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas.
Author: Suwa, H|Ohshio, G|Imamura, T|Watanabe, G|Arii, S|Imamura, M|Narumiya, S|Hiai, H|Fukumoto, M
PMID: 9459160
Journal: Int J Oncol. 1998 Mar;12(3):717-23.
Title: Lovastatin inhibits proliferation of pancreatic cancer cell lines with mutant as well as with wild-type K-ras oncogene but has different effects on protein phosphorylation and induction of apoptosis.
Author: Muller, C|Bockhorn, A G|Klusmeier, S|Kiehl, M|Roeder, C|Kalthoff, H|Koch, O M
PMID: 9472115
Journal: Cancer. 1998 Feb 15;82(4):651-60.
Title: Determination of pancreatic ductal carcinoma histogenesis by analysis of mucous quality and K-ras mutation.
Author: Matsubayashi, H|Watanabe, H|Nishikura, K|Ajioka, Y|Kijima, H|Saito, T
PMID: 9477096
Journal: Mol Carcinog. 1998 Feb;21(2):93-9.
Title: Selective cytotoxicity of farnesylamine to pancreatic carcinoma cells and Ki-ras-transformed fibroblasts.
Author: Ura, H|Obara, T|Shudo, R|Itoh, A|Tanno, S|Fujii, T|Nishino, N|Kohgo, Y
PMID: 9496909
Journal: Br J Surg. 1998 Mar;85(3):337-40.
Title: Genetic alterations in chronic pancreatitis: evidence for early occurrence of p53 but not K-ras mutations.
Author: Gansauge, S|Schmid, R M|Muller, J|Adler, G|Mattfeldt, T|Beger, H G
PMID: 9529487
Journal: Int J Oncol. 1998 May;12(5):1019-23.
Title: Usefulness of K-ras gene mutation at codon 12 in bile for diagnosing biliary strictures.
Author: Ito, R|Tamura, K|Ashida, H|Nishiwaki, M|Nishioka, A|Yamamoto, Y|Furuyama, J I|Utsunomiya, J
PMID: 9538122
Journal: Pancreas. 1998 Apr;16(3):349-54.
Title: Pancreatic cancer: medical aspects.
Author: Okada, S|Yoshimori, M|Kakizoe, T
PMID: 9548678
Journal: Digestion. 1998;59(2):120-4.
Title: K-ras mutations at codon 12 are rare events in chronic pancreatitis.
Author: Orth, M|Gansauge, F|Gansauge, S|Beger, H G|Adler, G|Schmid, R M
PMID: 9586823
Journal: Cancer. 1998 May 15;82(10):1839-49.
Title: Histologic and biologic patterns of microscopic pancreatic ductal adenocarcinomas detected incidentally at autopsy.
Author: Kimura, W|Morikane, K|Esaki, Y|Chan, W C|Pour, P M
PMID: 9587115
Journal: Pathol Int. 1998 Jan;48(1):33-40.
Title: Analysis of K-ras oncogene mutation directly applied to atypical cell clusters on cytologic smear slides of bile and pancreatic juice.
Author: Fukushima, N|Suzuki, M|Fukayama, M
PMID: 9589462
Journal: Am J Clin Pathol. 1998 Jun;109(6):704-11.
Title: Detection of K-ras point mutations in the supernatants of peritoneal and pleural effusions for diagnosis complementary to cytologic examination.
Author: Yamashita, K|Kuba, T|Shinoda, H|Takahashi, E|Okayasu, I
PMID: 9620027
Journal: Am J Pathol. 1998 Jun;152(6):1501-7.
Title: Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+.
Author: Goggins, M|Offerhaus, G J|Hilgers, W|Griffin, C A|Shekher, M|Tang, D|Sohn, T A|Yeo, C J|Kern, S E|Hruban, R H
PMID: 9626054
Journal: Cancer Epidemiol Biomarkers Prev. 1998 Jun;7(6):515-21.
Title: K-ras mutation in focal proliferative lesions of human pancreas.
Author: Terhune, P G|Phifer, D M|Tosteson, T D|Longnecker, D S
PMID: 9641496
Journal: Langenbecks Arch Surg. 1998 Apr;383(2):105-15.
Title: Molecular pattern of ductal pancreatic cancer.
Author: Sirivatanauksorn, V|Sirivatanauksorn, Y|Lemoine, N R
PMID: 9641882
Journal: J Gastroenterol. 1998 Jun;33(3):390-6.
Title: Detection of Ki-ras and p53 gene mutations in tissue and pancreatic juice from pancreatic adenocarcinomas.
Author: Kondoh, S|Kaino, M|Okita, S|Ryozawa, S|Akiyama, T|Okita, K
PMID: 9658319
Journal: Ann Surg. 1998 Jul;228(1):79-86.
Title: K-ras oncogene mutations indicate malignancy in cystic tumors of the pancreas.
Author: Bartsch, D|Bastian, D|Barth, P|Schudy, A|Nies, C|Kisker, O|Wagner, H J|Rothmund, M
PMID: 9671070
Journal: Semin Surg Oncol. 1998 Jul-Aug;15(1):40-6.
Title: Clinical application of K-ras oncogene mutations in pancreatic carcinoma: detection of micrometastases.
Author: Nomoto, S|Nakao, A|Ando, N|Takeda, S|Kasai, Y|Inoue, S|Kaneko, T|Takagi, H
PMID: 9671955
Journal: J Pathol. 1998 May;185(1):53-60.
Title: Undifferentiated carcinoma of the pancreas: analysis of intermediate filament profile and Ki-ras mutations provides evidence of a ductal origin.
Author: Hoorens, A|Prenzel, K|Lemoine, N R|Kloppel, G
PMID: 9713360
Journal: Presse Med. 1998 Mar 21;27(11):533-6.
Title: [Adenocarcinoma of the pancreas. General characteristics].
Author: Andre, T|Balosso, J|Louvet, C|Gligorov, J|Callard, P|de Gramont, A|Izrael, V
PMID: 9767968
Journal: Am J Surg Pathol. 1998 Oct;22(10):1247-54.
Title: K-ras oncogene mutations in osteoclast-like giant cell tumors of the pancreas and liver: genetic evidence to support origin from the duct epithelium.
Author: Westra, W H|Sturm, P|Drillenburg, P|Choti, M A|Klimstra, D S|Albores-Saavedra, J|Montag, A|Offerhaus, G J|Hruban, R H
PMID: 9777987
Journal: Clin Chem. 1998 Nov;44(11):2243-8.
Title: K-ras gene mutations in the diagnosis of fine-needle aspirates of pancreatic masses: prospective study using two techniques with different detection limits.
Author: Mora, J|Puig, P|Boadas, J|Urgell, E|Montserrat, E|Lerma, E|Gonzalez-Sastre, F|Lluis, F|Farre, A|Capella, G
PMID: 9799749
Journal: Clin Chem Lab Med. 1998 Aug;36(8):593-5.
Title: Restriction digest PCR (RD-PCR) for the analysis of gene mutations. Application to Ki-ras.
Author: Huber, K R|Bittner, J|Bauer, K|Trumper, L|Sek, A|Sebesta, C|Rosen, H|Tragl, K H
PMID: 9806467
Journal: Eur J Cancer. 1998 Aug;34(9):1455-9.
Title: Cholecystokinin receptors in human pancreatic cancer cell lines.
Author: Mandair, K K|Towner, P|Stamford, I F|Morris, J D|Harper, E|Benjamin, I S|Tavares, I A
PMID: 9849431
Journal: J Pathol. 1998 Sep;186(1):41-50.
Title: Pancreatic endocrine tumours: evidence for a tumour suppressor pathogenesis and for a tumour suppressor gene on chromosome 17p.
Author: Beghelli, S|Pelosi, G|Zamboni, G|Falconi, M|Iacono, C|Bordi, C|Scarpa, A
PMID: 9875139
Journal: Biochem Biophys Res Commun. 1998 Dec 18;253(2):368-73.
Title: Hammerhead ribozyme specifically inhibits mutant K-ras mRNA of human pancreatic cancer cells.
Author: Tsuchida, T|Kijima, H|Oshika, Y|Tokunaga, T|Abe, Y|Yamazaki, H|Tamaoki, N|Ueyama, Y|Scanlon, K J|Nakamura, M
PMID: 9878544
Journal: Eur J Gastroenterol Hepatol. 1998 Dec;10(12):1025-9.
Title: Analysis of K-ras gene mutations in rare pancreatic and ampullary tumours.
Author: Ebert, M P|Hoffmann, J|Schneider-Stock, R|Kasper, H U|Schulz, H U|Lippert, H|Roessner, A|Malfertheiner, P
PMID: 9895049
Journal: Eur J Histochem. 1998;42 Spec No:67-76.
Title: Ki-ras and p53 gene mutations in pancreatic ductal carcinoma: a relationship with tumor phenotype and survival.
Author: Sessa, F|Bonato, M|Bisoni, D|Ranzani, G N|Capella, C
PMID: 10076772
Journal: J Clin Epidemiol. 1998 Dec;51(12):1215-21.
Title: Learning from case reports: diagnostic issues in an epidemiologic study of pancreatic cancer.
Author: Soler, M|Porta, M|Malats, N|Guarner, L|Costafreda, S|Gubern, J M|Garcia-Olivares, E|Andreu, M|Real, F X
PMID: 10086813
Journal: Langenbecks Arch Chir Suppl Kongressbd. 1998;115(Suppl I):45-7.
Title: [Detection of hepatic micrometastasis in ductal pancreatic carcinoma by K-ras mutation analysis and determination of clinical relevance].
Author: Bastian, D|Gerdes, B|Ramaswamy, A|Tschammer, C|Bartsch, D
PMID: 14518210
Journal: Clin Cancer Res. 1999 Jan;5(1):119-27.
Title: The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells.
Author: Wang, W|Abbruzzese, J L|Evans, D B|Larry, L|Cleary, K R|Chiao, P J
PMID: 9918209
Journal: Int J Cancer. 1999 Feb 9;80(4):553-8.
Title: Growth inhibition of human pancreatic cancer cell lines by anti-sense oligonucleotides specific to mutated K-ras genes.
Author: Kita, K|Saito, S|Morioka, C Y|Watanabe, A
PMID: 9935156
Journal: J Clin Oncol. 1999 Feb;17(2):578-84.
Title: K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: diagnostic utility and prognostic significance.
Author: Castells, A|Puig, P|Mora, J|Boadas, J|Boix, L|Urgell, E|Sole, M|Capella, G|Lluis, F|Fernandez-Cruz, L|Navarro, S|Farre, A
PMID: 10080602
Journal: Cancer. 1999 Feb 15;85(4):832-40.
Title: Characterization of six cell lines established from human pancreatic adenocarcinomas.
Author: Kato, M|Shimada, Y|Tanaka, H|Hosotani, R|Ohshio, G|Ishizaki, K|Imamura, M
PMID: 10091760
Journal: Jpn J Cancer Res. 1999 Feb;90(2):240-8.
Title: K-ras point mutations in the supernatants of pancreatic juice and bile are reliable for diagnosis of pancreas and biliary tract carcinomas complementary to cytologic examination.
Author: Yamashita, K|Kida, Y|Shinoda, H|Kida, M|Okayasu, I
PMID: 10189896
Journal: Hepatogastroenterology. 1999 Jan-Feb;46(25):532-9.
Title: Significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas.
Author: Kimura, W|Zhao, B|Futakawa, N|Muto, T|Makuuchi, M
PMID: 10228857
Journal: Langenbecks Arch Surg. 1999 Apr;384(2):181-6.
Title: K-ras mutations in tissue and stool samples from patients with pancreatic cancer and chronic pancreatitis.
Author: Wenger, F A|Zieren, J|Peter, F J|Jacobi, C A|Muller, J M
PMID: 10328172
Journal: Gastroenterology. 1999 Jun;116(6):1441-52.
Title: Transforming growth factor alpha activates Ha-Ras in human pancreatic cancer cells with Ki-ras mutations.
Author: Seufferlein, T|Van Lint, J|Liptay, S|Adler, G|Schmid, R M
PMID: 10348828
Journal: Cancer. 1999 Jun 1;85(11):2352-8.
Title: Malignant fibrous histiocytoma of the pancreas: a case report with genetic analysis.
Author: Bastian, D|Ramaswamy, A|Barth, P J|Gerdes, B|Ernst, M|Bartsch, D
PMID: 10357405
Journal: Nucleic Acids Res. 1999 Jul 1;27(13):2737-44.
Title: Enzymatic and antisense effects of a specific anti-Ki-ras ribozyme in vitro and in cell culture.
Author: Giannini, C D|Roth, W K|Piiper, A|Zeuzem, S
PMID: 10373591
Journal: Hum Pathol. 1999 Jun;30(6):602-10.
Title: The role of p21ras in pancreatic neoplasia and chronic pancreatitis.
Author: Mulligan, N J|Yang, S|Andry, C|Klein, M|O'Brien, M J
PMID: 10374765
Journal: J Cancer Res Clin Oncol. 1999 Jul;125(7):395-401.
Title: Enrichment polymerase chain reaction for the detection of Ki-ras mutations: relevance of Taq polymerase error rate, initial DNA copy number, and reaction conditions on the emergence of false-positive mutant bands.
Author: Jacobs, G|Tscholl, E|Sek, A|Pfreundschuh, M|Daus, H|Trumper, L
PMID: 10394959
Journal: Int J Oncol. 1999 Aug;15(2):271-9.
Title: Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression.
Author: Yip-Schneider, M T|Lin, A|Barnard, D|Sweeney, C J|Marshall, M S
PMID: 10402237
Journal: Ann N Y Acad Sci. 1999 Jun 30;880:210-8.
Title: Ki-ras oncogene mutations in chronic pancreatitis: which discriminating ability for malignant potential?
Author: van Laethem, J L
PMID: 10415866
Journal: Ann Oncol. 1999;10 Suppl 4:41-5.
Title: In vitro pancreatic carcinogenesis.
Author: Schmied, B M|Ulrich, A|Matsuzaki, H|Li, C H|Pour, P M
PMID: 10436783
Journal: Ann Oncol. 1999;10 Suppl 4:114-7.
Title: Diagnosis of pancreatico-biliary malignancy: detection of gene mutations in plasma and stool.
Author: Mulcahy, H|Farthing, M J
PMID: 10436800
Journal: Anticancer Res. 1999 Jul-Aug;19(4A):2481-3.
Title: Analysis of K-ras mutations in pancreatic tissue after fine needle aspirates.
Author: Pabst, B|Arps, S|Binmoeller, K|Thul, R|Walsemann, G|Fenner, C|Klapdor, R
PMID: 10470178
Journal: Rev Hosp Clin Fac Med Sao Paulo. 1999 Jan-Feb;54(1):17-20.
Title: Detection of codon 12 mutation in the K-ras oncogene in pancreatic tumors.
Author: Kubrusly, M S|Matheucci Junior, E|Leite, K R|Coelho, A M|Monte, O|Machado, M C|Pinotti, H W
PMID: 10488596
Journal: Hepatogastroenterology. 1999 Jul-Aug;46(28):2575-81.
Title: Ki-ras codon 12 point mutation and p53 mutation in pancreatic diseases.
Author: Yamaguchi, K|Chijiiwa, K|Noshiro, H|Torata, N|Kinoshita, M|Tanaka, M
PMID: 10522044
Journal: Ann Surg. 1999 Oct;230(4):501-9; discussion 509-11.
Title: Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy.
Author: Jimenez, R E|Warshaw, A L|Z'graggen, K|Hartwig, W|Taylor, D Z|Compton, C C|Fernandez-del Castillo, C
PMID: 10522720
Journal: Dig Dis Sci. 1999 Oct;44(10):2014-9.
Title: Detection of pancreatic carcinoma: diagnostic value of K-ras mutations in circulating DNA from serum.
Author: Theodor, L|Melzer, E|Sologov, M|Idelman, G|Friedman, E|Bar-Meir, S
PMID: 10548352
Journal: Virchows Arch. 1999 Nov;435(5):461-8.
Title: Duct changes and K-ras mutations in the disease-free pancreas: analysis of type, age relation and spatial distribution.
Author: Luttges, J|Reinecke-Luthge, A|Mollmann, B|Menke, M A|Clemens, A|Klimpfinger, M|Sipos, B|Kloppel, G
PMID: 10592048
Journal: Lancet. 1999 Dec 18-25;354(9196):2125-9.
Title: Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group.
Author: Porta, M|Malats, N|Jariod, M|Grimalt, J O|Rifa, J|Carrato, A|Guarner, L|Salas, A|Santiago-Silva, M|Corominas, J M|Andreu, M|Real, F X
PMID: 10609819
Journal: Nutr Cancer. 1999;35(1):80-6.
Title: Chemopreventive effects of tea extracts and various components on human pancreatic and prostate tumor cells in vitro.
Author: Lyn-Cook, B D|Rogers, T|Yan, Y|Blann, E B|Kadlubar, F F|Hammons, G J
PMID: 10624710
Journal: J Epidemiol Community Health. 1999 Nov;53(11):702-9.
Title: Association between coffee drinking and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group.
Author: Porta, M|Malats, N|Guarner, L|Carrato, A|Rifa, J|Salas, A|Corominas, J M|Andreu, M|Real, F X
PMID: 10656099
Journal: Int J Pancreatol. 1999 Dec;26(3):155-62.
Title: Detection of extrapancreatic nerve plexus invasion of pancreatic adenocarcinoma. Cytokeratin 19 staining and K-ras mutation.
Author: Suwa, H|Hosotani, R|Kogire, M|Doi, R|Ohshio, G|Fukumoto, M|Imamura, M
PMID: 10732292
Journal: Zhonghua Nei Ke Za Zhi. 1999 Oct;38(10):673-6.
Title: [K-ras mutation in pancreatic juice from patients with pancreatic carcinoma].
Author: Gong, X|Chen, Y|Chen, Y|Lu, X
PMID: 11798705
Journal: Zhonghua Bing Li Xue Za Zhi. 1999 Dec;28(6):422-6.
Title: [The establishment of a human pancreatic mixed ductal-endocrine carcinoma cell line].
Author: Hou, M|Gao, J|Liu, T|Cui, Q
PMID: 11869555
Journal: Curr Opin Gastroenterol. 1999 Sep;15(5):404-9.
Title: Molecular genetics and related developments in pancreatic cancer.
Author: Hruban, R H|Goggins, M|Kern, S E
PMID: 17023981
Journal: Nihon Geka Gakkai Zasshi. 2000 Feb;101(2):233-6.
Title: [General rules for the study of pancreatic cancer by molecular biological aspect].
Author: Omata, M|Tada, M
PMID: 10734643
Journal: Cancer Epidemiol Biomarkers Prev. 2000 Mar;9(3):279-84.
Title: Ki-ras point mutation and p53 expression in human pancreatic cancer: a comparative study among Chinese, Japanese, and Western patients.
Author: Dong, M|Nio, Y|Tamura, K|Song, M M|Guo, K J|Guo, R X|Dong, Y T
PMID: 10750666
Journal: Cancer Gene Ther. 2000 Mar;7(3):373-83.
Title: Adenovirus-mediated anti-K-ras ribozyme induces apoptosis and growth suppression of human pancreatic carcinoma.
Author: Tsuchida, T|Kijima, H|Hori, S|Oshika, Y|Tokunaga, T|Kawai, K|Yamazaki, H|Ueyama, Y|Scanlon, K J|Tamaoki, N|Nakamura, M
PMID: 10766343
Journal: Am J Pathol. 2000 May;156(5):1767-71.
Title: BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: evidence and implications.
Author: Goggins, M|Hruban, R H|Kern, S E
PMID: 10793087
Journal: Int J Pancreatol. 2000 Feb;27(1):69-76.
Title: Solid and cystic tumor of the pancreas: clinicopathologic and genetic studies of four cases.
Author: Yamaue, H|Tanimura, H|Shono, Y|Onishi, H|Tani, M|Yamoto, H|Kinoshita, H|Uchiyama, K
PMID: 10811026
Journal: Int J Oncol. 2000 Jun;16(6):1165-71.
Title: Outcome of pancreatic cancer patients based on genetic lymph node staging.
Author: Yamada, T|Nakamori, S|Ohzato, H|Higaki, N|Aoki, T|Oshima, S|Shiozaki, K|Okami, J|Hayashi, N|Nagano, H|Dono, K|Umeshita, K|Sakon, M|Monden, M
PMID: 10811991
Journal: Cancer. 2000 May 1;88(9):2010-21.
Title: Characterization of a newly established human pancreatic carcinoma cell line, UK Pan-1.
Author: Fralix, K D|Ahmed, M M|Mattingly, C|Swiderski, C|McGrath, P C|Venkatasubbarao, K|Kamada, N|Mohiuddin, M|Strodel, W E|Freeman, J W
PMID: 10813711
Journal: Cancer Lett. 2000 Jul 31;155(2):153-61.
Title: Establishment of a new human pancreatic cancer cell line, NOR-P1, with high angiogenic activity and metastatic potential.
Author: Sato, N|Mizumoto, K|Beppu, K|Maehara, N|Kusumoto, M|Nabae, T|Morisaki, T|Katano, M|Tanaka, M
PMID: 10822130
Journal: Gastrointest Endosc. 2000 Jun;51(6):708-13.
Title: Telomerase activity in pure pancreatic juice for the diagnosis of pancreatic cancer may be complementary to K-ras mutation.
Author: Myung, S J|Kim, M H|Kim, Y S|Kim, H J|Park, E T|Yoo, K S|Lim, B C|Wan Seo, D|Lee, S K|Min, Y I|Kim, J Y
PMID: 10840305
Journal: Clin Cancer Res. 2000 Jun;6(6):2129-37.
Title: Detection of mutated KRAS2 sequences as tumor markers in plasma/serum of patients with gastrointestinal cancer.
Author: Sorenson, G D
PMID: 10873061
Journal: Rinsho Byori. 2000 Jun;48(6):547-53.
Title: [Characteristics of plasma DNA and its application for detection of K-ras gene mutation].
Author: Hayashi, T|Sugahara, K|Dateki, N|Yamada, Y|Sudou, R|Kanematsu, T|Kamihira, S
PMID: 10897674
Journal: Mol Biotechnol. 2000 Jan;14(1):59-72.
Title: Ribozyme as an approach for growth suppression of human pancreatic cancer.
Author: Kijima, H|Scanlon, K J
PMID: 10911615
Journal: Hum Pathol. 2000 Jul;31(7):795-803.
Title: K-ras gene mutations and loss of heterozygosity at the p53 gene locus relative to histological characteristics of mucin-producing tumors of the pancreas.
Author: Sakai, Y|Yanagisawa, A|Shimada, M|Hidaka, E|Seki, M|Tada, Y|Harada, T|Saisho, H|Kato, Y
PMID: 10923915
Journal: Am J Gastroenterol. 2000 Aug;95(8):1939-45.
Title: Ki-ras codon 12 point and P53 mutations: a molecular examination of the main tumor, liver, portal vein, peripheral arterial blood and para-aortic lymph node in pancreatic cancer.
Author: Yamaguchi, K|Chijiiwa, K|Torato, N|Kinoshita, M|Tanaka, M
PMID: 10950039
Journal: Am J Gastroenterol. 2000 Aug;95(8):2080-5.
Title: Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma.
Author: Yatsuoka, T|Sunamura, M|Furukawa, T|Fukushige, S|Yokoyama, T|Inoue, H|Shibuya, K|Takeda, K|Matsuno, S|Horii, A
PMID: 10950061
Journal: Anticancer Res. 2000 Jul-Aug;20(4):2469-72.
Title: Clinical value of bile for the detection of mutant K-ras from colorectal liver metastases.
Author: de Kok, J B|Swinkels, D W|Ruers, T J
PMID: 10953312
Journal: Cancer Res. 2000 Oct 1;60(19):5451-5.
Title: Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells.
Author: Ng SSW|Tsao, M S|Chow, S|Hedley, D W
PMID: 11034087
Journal: Hum Pathol. 2000 Oct;31(10):1223-9.
Title: Origin of giant cells in osteoclast-like giant cell tumors of the pancreas.
Author: Sakai, Y|Kupelioglu, A A|Yanagisawa, A|Yamaguchi, K|Hidaka, E|Matsuya, S|Ohbuchi, T|Tada, Y|Saisho, H|Kato, Y
PMID: 11070115
Journal: J Surg Oncol. 2000 Nov;75(3):176-85.
Title: Comparison of K-ras point mutations at codon 12 and p21 expression in pancreatic cancer between Japanese and Chinese patients.
Author: Song, M M|Nio, Y|Dong, M|Tamura, K|Furuse, K|Tian, Y L|He, S G|Shen, K
PMID: 11088049
Journal: Cancer Epidemiol Biomarkers Prev. 2000 Nov;9(11):1223-32.
Title: K-ras and p53 in pancreatic cancer: association with medical history, histopathology, and environmental exposures in a population-based study.
Author: Slebos, R J|Hoppin, J A|Tolbert, P E|Holly, E A|Brock, J W|Zhang, R H|Bracci, P M|Foley, J|Stockton, P|McGregor, L M|Flake, G P|Taylor, J A
PMID: 11097231
Journal: Arch Surg. 2000 Dec;135(12):1450-5.
Title: K-ras point mutation in the nerve plexuses around the superior mesenteric artery in resectable adenocarcinoma of the pancreatic head: distribution pattern and related factors.
Author: Ohigashi, H|Ishikawa, O|Sasaki, Y|Yamada, T|Furukawa, H|Imaoka, S|Kasugai, T|Ishiguro, S|Ueda, K|Miyoshi, Y|Nakamura, Y
PMID: 11115351
Journal: Zhonghua Wai Ke Za Zhi. 2000 Oct;38(10):767-70.
Title: [Detection of K-ras gene mutations in DNA extracted from the plasma of patients with pancreatic cancer].
Author: Feng, D|Han, T|Jiang, Y|Yuan, Z|Wang, X|Jiang, Z|Zhang, S
PMID: 11832160
Journal: Am J Surg Pathol. 2001 Jan;25(1):26-42.
Title: Colloid (mucinous noncystic) carcinoma of the pancreas.
Author: Adsay, N V|Pierson, C|Sarkar, F|Abrams, J|Weaver, D|Conlon, K C|Brennan, M F|Klimstra, D S
PMID: 11145249
Journal: Int J Cancer. 2001 Feb 1;91(3):350-8.
Title: Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping.
Author: Sirivatanauksorn, V|Sirivatanauksorn, Y|Gorman, P A|Davidson, J M|Sheer, D|Moore, P S|Scarpa, A|Edwards, P A|Lemoine, N R
PMID: 11169959
Journal: Mol Ther. 2001 Apr;3(4):491-9.
Title: Suppression of colorectal cancer growth using an adenovirus vector expressing an antisense K-ras RNA.
Author: Nakano, M|Aoki, K|Matsumoto, N|Ohnami, S|Hatanaka, K|Hibi, T|Terada, M|Yoshida, T
PMID: 11319909
Journal: Cancer Res. 2001 May 15;61(10):4222-8.
Title: Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation.
Author: Ellenrieder, V|Hendler, S F|Boeck, W|Seufferlein, T|Menke, A|Ruhland, C|Adler, G|Gress, T M
PMID: 11358848
Journal: Lab Invest. 2001 Jun;81(6):827-31.
Title: Enrichment of mutant KRAS alleles in pancreatic juice by subtractive iterative polymerase chain reaction.
Author: Fischer, C|Buthe, J|Nollau, P|Hollerbach, S|Schulmann, K|Schmiegel, W|Wagener, C|Tschentscher, P
PMID: 11406644
Journal: Lab Invest. 2001 Jun;81(6):863-73.
Title: Doc-2/hDab2 expression is up-regulated in primary pancreatic cancer but reduced in metastasis.
Author: Huang, Y|Friess, H|Kleeff, J|Esposito, I|Zhu, Z|Liu, S|Mok, S C|Zimmermann, A|Buchler, M W
PMID: 11406647
Journal: Int J Oncol. 2001 Jul;19(1):71-81.
Title: Altered expression of TGFB receptors and mitogenic effects of TGFB in pancreatic carcinomas.
Author: Jonson, T|Albrechtsson, E|Axelson, J|Heidenblad, M|Gorunova, L|Johansson, B|Hoglund, M
PMID: 11408925
Journal: Hepatogastroenterology. 2001 Jul-Aug;48(40):933-8.
Title: Molecular diagnosis of pancreatic cancer.
Author: Inoue, S|Tezel, E|Nakao, A
PMID: 11490843
Journal: Cancer. 2001 Aug 1;92(3):488-99.
Title: The association of K-ras gene mutation and vascular endothelial growth factor gene expression in pancreatic carcinoma.
Author: Ikeda, N|Nakajima, Y|Sho, M|Adachi, M|Huang, C L|Iki, K|Kanehiro, H|Hisanaga, M|Nakano, H|Miyake, M
PMID: 11505392
Journal: Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10332-7.
Title: A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells.
Author: Su , Z|Lebedeva, I V|Gopalkrishnan, R V|Goldstein, N I|Stein, C A|Reed, J C|Dent, P|Fisher, P B
PMID: 11526239
Journal: Cancer J. 2001 Jul-Aug;7(4):259-65.
Title: Molecular epidemiology of pancreatic cancer.
Author: Li, D
PMID: 11561602
Journal: Pancreas. 2001 Nov;23(4):356-63.
Title: Usefulness of supernatant of pancreatic juice for genetic analysis of K-ras in diagnosis of pancreatic carcinoma.
Author: Ha, A|Watanabe, H|Yamaguchi, Y|Ohtsubo, K|Wang, Y|Motoo, Y|Okai, T|Wakabayahi, T|Sawabu, N
PMID: 11668203
Journal: Hum Mutat. 2001 Oct;18(4):357.
Title: Oncogenic levels of mitogen-activated protein kinase (MAPK) signaling of the dinucleotide KRAS2 mutations G12F and GG12-13VC.
Author: Feldser, D M|Kern, S E
PMID: 11668624
Journal: Am J Pathol. 2001 Nov;159(5):1619-27.
Title: Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas : frequent alterations in the APC/beta-catenin pathway and chromosome 11p.
Author: Abraham, S C|Wu, T T|Klimstra, D S|Finn, L S|Lee, J H|Yeo, C J|Cameron, J L|Hruban, R H
PMID: 11696422
Journal: Eur J Gastroenterol Hepatol. 2001 Oct;13(10):1141-2.
Title: Does detection of K-ras mutations in pancreatic juice influence clinical decision making?
Author: O'Mahony, S|Sreedharan, A
PMID: 11711767
Journal: Eur J Gastroenterol Hepatol. 2001 Oct;13(10):1153-9.
Title: Clinical usefulness of K-ras gene mutation detection and cytology in pancreatic juice in the diagnosis and screening of pancreatic cancer.
Author: Boadas, J|Mora, J|Urgell, E|Puig, P|Roca, M|Cusso, X|Capella, G|Lluis, F|Farre, A
PMID: 11711770
Journal: Cancer Res. 2001 Dec 15;61(24):8758-68.
Title: Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
Author: Lobell, R B|Omer, C A|Abrams, M T|Bhimnathwala, H G|Brucker, M J|Buser, C A|Davide, J P|deSolms, S J|Dinsmore, C J|Ellis-Hutchings, M S|Kral, A M|Liu, D|Lumma, W C|Machotka, S V|Rands, E|Williams, T M|Graham, S L|Hartman, G D|Oliff, A I|Heimbrook, D C|Koh
PMID: 11751396
Journal: Mutat Res. 2002 Jan 15;513(1-2):37-48.
Title: DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer.
Author: Li, Donghui|Firozi, Pervez F|Zhang, Weiqing|Shen, Jianjun|DiGiovanni, John|Lau, Serrine|Evans, Douglas|Friess, Helmut|Hassan, Manal|Abbruzzese, James L
PMID: 11719088
Journal: Ann Epidemiol. 2002 Jan;12(1):7-14.
Title: Generalizing molecular results arising from incomplete biological samples: expected bias and unexpected findings.
Author: Porta, Miquel|Malats, Nuria|Corominas, Josep M|Rifa, Juli|Pinol, Josep L|Real, Francisco X
PMID: 11750234
Journal: Carcinogenesis. 2002 Jan;23(1):101-6.
Title: Occupational exposure to organic solvents and K-ras mutations in exocrine pancreatic cancer.
Author: Alguacil, Juan|Porta, Miquel|Malats, Nuria|Kauppinen, Timo|Kogevinas, Manolis|Benavides, Fernando G|Partanen, Timo|Carrato, Alfredo
PMID: 11756230
Journal: Clin Chem. 2002 Mar;48(3):428-35.
Title: Diagnostic biochip array for fast and sensitive detection of K-ras mutations in stool.
Author: Prix, Lothar|Uciechowski, Peter|Bockmann, Beatrix|Giesing, Michael|Schuetz, Andreas J
PMID: 11861435
Journal: Am J Pathol. 2002 Apr;160(4):1361-9.
Title: Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations.
Author: Abraham, Susan C|Klimstra, David S|Wilentz, Robb E|Yeo, Charles J|Conlon, Kevin|Brennan, Murray|Cameron, John L|Wu, Tsung-Teh|Hruban, Ralph H
PMID: 11943721
Journal: Mod Pathol. 2002 Apr;15(4):441-7.
Title: Direct correlation between proliferative activity and dysplasia in pancreatic intraepithelial neoplasia (PanIN): additional evidence for a recently proposed model of progression.
Author: Klein, Walter M|Hruban, Ralph H|Klein-Szanto, Andres J P|Wilentz, Robb E
PMID: 11950919
Journal: Genes Chromosomes Cancer. 2002 Jun;34(2):211-23.
Title: Detailed genomic mapping and expression analyses of 12p amplifications in pancreatic carcinomas reveal a 3.5-Mb target region for amplification.
Author: Heidenblad, Markus|Jonson, Tord|Mahlamaki, Eija H|Gorunova, Ludmila|Karhu, Ritva|Johansson, Bertil|Hoglund, Mattias
PMID: 11979555
Journal: J Hepatobiliary Pancreat Surg. 2002;9(1):1-11.
Title: Molecular prognostic markers in pancreatic cancer.
Author: Ghaneh, Paula|Kawesha, Anthony|Evans, James D|Neoptolemos, John P
PMID: 12021893
Journal: Hematol Oncol Clin North Am. 2002 Feb;16(1):17-35, v.
Title: Molecular pathogenesis of pancreatic cancer.
Author: Hilgers, Werner|Rosty, Christophe|Hahn, Stephan A
PMID: 12063826
Journal: Jpn J Clin Oncol. 2002 Apr;32(4):146-51.
Title: Invasive ductal adenocarcinoma of the remnant pancreatic body 9 years after resection of an intraductal papillary-mucinous carcinoma of the pancreatic head: a case report and comparison of DNA sequence in K-ras gene mutation.
Author: Komori, Takamichi|Ishikawa, Osamu|Ohigashi, Hiroaki|Yamada, Terumasa|Sasaki, Yo|Imaoka, Shingi|Nakaizumi, Akihiko|Uehara, Hiroyuki|Tanaka, Sachiko|Mano, Yoshiyuki|Kasugai, Tsutomu
PMID: 12072425
Journal: Pancreatology. 2002;2(1):17-25.
Title: Frequent deletions of tumor suppressor genes in pure pancreatic juice from patients with tumoral or nontumoral pancreatic diseases.
Author: Costentin, Lydie|Pages, Philippe|Bouisson, Michele|Berthelemy, Philippe|Buscail, Louis|Escourrou, Jean|Pradayrol, Lucien|Vaysse, Nicole
PMID: 12120000
Journal: Oncogene. 2002 Aug 29;21(38):5923-8.
Title: Dominant negative MEKK1 inhibits survival of pancreatic cancer cells.
Author: Hirano, Tatsuya|Shino, Yuji|Saito, Takeshi|Komoda, Fumitake|Okutomi, Yoshiyuki|Takeda, Akiko|Ishihara, Takeshi|Yamaguchi, Taketo|Saisho, Hiromitsu|Shirasawa, Hiroshi
PMID: 12185592
Journal: Br J Cancer. 2002 Aug 27;87(5):551-4.
Title: Differential diagnosis between chronic pancreatitis and pancreatic cancer: value of the detection of KRAS2 mutations in circulating DNA.
Author: Maire, F|Micard, S|Hammel, P|Voitot, H|Levy, P|Cugnenc, P-H|Ruszniewski, P|Puig, P Laurent
PMID: 12189555
Journal: Clin Chim Acta. 2002 Oct;324(1-2):105-11.
Title: Quantity of mutant K-ras gene in pancreatic secretions for diagnosis of pancreatic carcinoma with different assays: analysis of 100 patients.
Author: Tada, Minoru|Tateishi, Keisuke|Kawabe, Takao|Sasahira, Naoki|Isayama, Hiroyuki|Komatsu, Yutaka|Shiratori, Yasushi|Omata, Masao
PMID: 12204431
Journal: Br J Cancer. 2002 Oct 7;87(8):898-904.
Title: Hyperstable U1snRNA complementary to the K-ras transcripts induces cell death in pancreatic cancer cells.
Author: Kato, K|Hitomi, Y|Imamura, K|Esumi, H
PMID: 12373606
Journal: J Clin Oncol. 2002 Nov 1;20(21):4331-7.
Title: Low sensitivity of the ki-ras polymerase chain reaction for diagnosing pancreatic cancer from pancreatic juice and bile: a multicenter prospective trial.
Author: Trumper, Lorenz|Menges, Markus|Daus, Heiner|Kohler, Daniel|Reinhard, Jan-Olaf|Sackmann, Michael|Moser, Cornelius|Sek, Alexandra|Jacobs, Georg|Zeitz, Martin|Pfreundschuh, Michael
PMID: 12409332
Journal: Ann Pathol. 2002 Oct;22(5):349-55.
Title: [Molecular pathways of pancreatic carcinogenesis].
Author: Torrisani, Jerome|Buscail, Louis
PMID: 12483152
Journal: Hepatobiliary Pancreat Dis Int. 2002 Aug;1(3):469-76.
Title: Neural invasion in pancreatic carcinoma.
Author: Liu, Bin|Lu, Kui-Yang
PMID: 14607730
Journal: World J Gastroenterol. 2003 Jan;9(1):188-91.
Title: K-ras gene mutation in the diagnosis of ultrasound guided fine-needle biopsy of pancreatic masses.
Author: Zheng, Min|Liu, Lian-Xin|Zhu, An-Long|Qi, Shu-Yi|Jiang, Hong-Chi|Xiao, Zhu-Ying
PMID: 12508380
Journal: Br J Cancer. 2003 Feb 24;88(4):530-6.
Title: Specific T-cell immunity against Ki-ras peptides in patients with pancreatic and colorectal cancers.
Author: Shono, Y|Tanimura, H|Iwahashi, M|Tsunoda, T|Tani, M|Tanaka, H|Matsuda, K|Yamaue, H
PMID: 12592366
Journal: Cancer Res. 2003 Mar 15;63(6):1297-303.
Title: The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma.
Author: Cullen, Joseph J|Weydert, Christine|Hinkhouse, Marilyn M|Ritchie, Justine|Domann, Frederick E|Spitz, Douglas|Oberley, Larry W
PMID: 12649190
Journal: Ai Zheng. 2003 Mar;22(3):295-7.
Title: [Significance of detection of K-ras gene mutations and CA19-9 in serum for diagnosis of pancreatic carcinoma].
Author: Zhang, Yi|Ji, Shu-Rong|Feng, Dian-Xu|Ji, Jun|Han, Tian-Quan
PMID: 12654190
Journal: Cancer Res. 2003 May 1;63(9):2005-9.
Title: The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice.
Author: Brembeck, Felix H|Schreiber, Franz S|Deramaudt, Therese B|Craig, Linden|Rhoades, Ben|Swain, Gary|Grippo, Paul|Stoffers, Doris A|Silberg, Debra G|Rustgi, Anil K
PMID: 12727809
Journal: Cancer Res. 2003 May 1;63(9):2016-9.
Title: Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice.
Author: Grippo, Paul J|Nowlin, Patrick S|Demeure, Michael J|Longnecker, Daniel S|Sandgren, Eric P
PMID: 12727811
Journal: Oncogene. 2003 Jun 12;22(24):3806-12.
Title: Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma.
Author: Dammann, Reinhard|Schagdarsurengin, Undraga|Liu, Limin|Otto, Noreen|Gimm, Oliver|Dralle, Henning|Boehm, Bernhard O|Pfeifer, Gerd P|Hoang-Vu, Cuong
PMID: 12802288
Journal: Medicina (Kaunas). 2003;39(7):631-6.
Title: [Molecular factors of pancreatic cancer pathogenesis and prognosis].
Author: Brasiuniene, Birute|Brasiunas, Vytautas|Barauskas, Giedrius|Juozaityte, Elona
PMID: 12878815
Journal: Zhonghua Wai Ke Za Zhi. 2003 May;41(5):332-5.
Title: [Combined detection of K-ras mutation and CA 19-9 level in plasma of patients with pancreatic cancer].
Author: Dai, Meng-hua|Zhao, Yu-pei|Cai, Li-xing|Zhu, Yu
PMID: 12892584
Journal: Vnitr Lek. 2003 Jul;49(7):559-62.
Title: [Molecular diagnosis in pancreatic carcinoma].
Author: Dite, P|Lukas, Z|Hermanova, M|Kroupova, I|Kleibl, Z|Brazdil, J|Pazourkova, M|Novotny, Z|Ruzicka, M
PMID: 12931440
Journal: Am J Surg. 2003 Sep;186(3):279-86.
Title: The genetics of pancreatic cancer.
Author: Cowgill, Sarah M|Muscarella, Peter
PMID: 12946833
Journal: Int J Oncol. 2003 Oct;23(4):1127-34.
Title: Survival regulation in pancreatic cancer cells by c-Jun.
Author: Okutomi, Yoshiyuki|Shino, Yuji|Komoda, Fumitake|Hirano, Tatsuya|Ishihara, Takeshi|Yamaguchi, Taketo|Saisho, Hiromitsu|Shirasawa, Hiroshi
PMID: 12963995
Journal: Cancer Lett. 2003 Sep 25;199(2):169-73.
Title: BRAF and K-ras gene mutations in human pancreatic cancers.
Author: Ishimura, Norihisa|Yamasawa, Kunihiro|Karim Rumi, Mohammad Azharul|Kadowaki, Yasunori|Ishihara, Shunji|Amano, Yuji|Nio, Yoshinori|Higami, Tetsuya|Kinoshita, Yoshikazu
PMID: 12969789
Journal: Am J Pathol. 2003 Oct;163(4):1255-60.
Title: BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets.
Author: Calhoun, Eric S|Jones, Jessa B|Ashfaq, Raheela|Adsay, Volkan|Baker, Suzanne J|Valentine, Virginia|Hempen, Paula M|Hilgers, Werner|Yeo, Charles J|Hruban, Ralph H|Kern, Scott E
PMID: 14507635
Journal: Hepatobiliary Pancreat Dis Int. 2003 May;2(2):313-7.
Title: Detection of K-ras gene mutation at codon 12 by pancreatic duct brushing for pancreatic cancer.
Author: Liu, Feng|Li, Zhao-Shen|Xu, Guo-Ming|Sun, Zhen-Xing|Zhou, Guo-Xiong|Ren, Xue-Xin|Tu, Zhen-Xing|Gong, Yan-Fang
PMID: 14599992
Journal: Chin Med J (Engl). 2003 Oct;116(10):1585-7.
Title: Unique GGT --> GTT mutation at K-ras codon 12 in six human pancreatic cancer cell lines from Chinese patients.
Author: Wei, Shuanzeng|Liu, Tonghua|Liu, Hongrui|Gao, Jie
PMID: 14640107
Journal: Genes Dev. 2003 Dec 15;17(24):3112-26.
Title: Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma.
Author: Aguirre, Andrew J|Bardeesy, Nabeel|Sinha, Manisha|Lopez, Lyle|Tuveson, David A|Horner, James|Redston, Mark S|DePinho, Ronald A
PMID: 14681207
Journal: Cancer Cell. 2003 Dec;4(6):437-50.
Title: Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse.
Author: Hingorani, Sunil R|Petricoin, Emanuel F|Maitra, Anirban|Rajapakse, Vinodh|King, Catrina|Jacobetz, Michael A|Ross, Sally|Conrads, Thomas P|Veenstra, Timothy D|Hitt, Ben A|Kawaguchi, Yoshiya|Johann, Don|Liotta, Lance A|Crawford, Howard C|Putt, Mary E|Jacks,
PMID: 14706336
Journal: Acta Gastroenterol Latinoam. 2003;33(1):43-6.
Title: K-ras as a genetic marker in pancreatic cancer.
Author: Nakayama, Takamori|Morishita, Tetsuo|Kamiya, Toshiaki
PMID: 14708511
Journal: J Cell Physiol. 2004 Feb;198(2):277-94.
Title: Characterization of p21Ras-mediated apoptosis induced by protein kinase C inhibition and application to human tumor cell lines.
Author: Liou, James S|Chen, James S|Faller, Douglas V
PMID: 14603530
Journal: Clin Chem. 2004 Mar;50(3):481-9.
Title: Rapid detection of K-ras mutations in bile by peptide nucleic acid-mediated PCR clamping and melting curve analysis: comparison with restriction fragment length polymorphism analysis.
Author: Chen, Chiung-Yu|Shiesh, Shu-Chu|Wu, Sheu-Jen
PMID: 14718395
Journal: Genes Chromosomes Cancer. 2004 Mar;39(3):224-35.
Title: Expression profiling of the influence of RAS mutants on the TGFB1-induced phenotype of the pancreatic cancer cell line PANC-1.
Author: Fensterer, Heiko|Giehl, Klaudia|Buchholz, Malte|Ellenrieder, Volker|Buck, Anita|Kestler, Hans A|Adler, Guido|Gierschik, Peter|Gress, Thomas M
PMID: 14732924
Journal: Carcinogenesis. 2004 Jun;25(6):1015-26.
Title: Pancreatic cancer cells express 25-hydroxyvitamin D-1 alpha-hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3.
Author: Schwartz, Gary G|Eads, Dawn|Rao, Anuradha|Cramer, Scott D|Willingham, Mark C|Chen, Tai C|Jamieson, Daniel P|Wang, Lilin|Burnstein, Kerry L|Holick, Michael F|Koumenis, Constantinos
PMID: 14742320
Journal: Int J Oncol. 2004 Mar;24(3):559-64.
Title: Ribozyme against mutant K-ras mRNA suppresses tumor growth of pancreatic cancer.
Author: Kijima, Hiroshi|Yamazaki, Hitoshi|Nakamura, Masato|Scanlon, Kevin J|Osamura, R Yoshiyuki|Ueyama, Yoshito
PMID: 14767540
Journal: J Gastroenterol. 2004 Jan;39(1):56-60.
Title: Detection of K-ras mutations in the plasma DNA of pancreatic cancer patients.
Author: Uemura, Takanori|Hibi, Kenji|Kaneko, Tetsuya|Takeda, Shin|Inoue, Soichiro|Okochi, Osamu|Nagasaka, Tetsuro|Nakao, Akimasa
PMID: 14767735
Journal: World J Gastroenterol. 2004 Feb 15;10(4):471-5.
Title: Values of mutations of K-ras oncogene at codon 12 in detection of pancreatic cancer: 15-year experience.
Author: Mu, De-Qing|Peng, You-Shu|Xu, Qiao-Jian
PMID: 14966900
Journal: Biochemistry. 2004 Mar 9;43(9):2512-23.
Title: G-rich oligonucleotide inhibits the binding of a nuclear protein to the Ki-ras promoter and strongly reduces cell growth in human carcinoma pancreatic cells.
Author: Cogoi, Susanna|Quadrifoglio, Franco|Xodo, Luigi E
PMID: 14992588
Journal: World J Gastroenterol. 2004 Mar 15;10(6):881-4.
Title: Detection of point mutation in K-ras oncogene at codon 12 in pancreatic diseases.
Author: Ren, Yue-Xin|Xu, Guo-Ming|Li, Zhao-Shen|Song, Yu-Gang
PMID: 15040037
Journal: Lancet. 2004 Mar 27;363(9414):1049-57.
Title: Pancreatic cancer.
Author: Li, Donghui|Xie, Keping|Wolff, Robert|Abbruzzese, James L
PMID: 15051286
Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004 Feb;26(1):79-82.
Title: [Recent advances in gene change of pancreatic cancer].
Author: Wang, Yu-yue|Cui, Quan-cai
PMID: 15052782
Journal: World J Gastroenterol. 2004 May 1;10(9):1337-40.
Title: Detection of K-ras point mutation and telomerase activity during endoscopic retrograde cholangiopancreatography in diagnosis of pancreatic cancer.
Author: Zhou, Guo-Xiong|Huang, Jie-Fei|Li, Zhao-Shen|Xu, Guo-Ming|Liu, Feng|Zhang, Hong
PMID: 15112354
Journal: In Vivo. 2004 Mar-Apr;18(2):113-7.
Title: Antisense therapy specific to mutated K-ras gene in hamster pancreatic cancer model. Can it inhibit the growth of 5-FU and MMC-resistant metastatic and remetastatic cell lines?
Author: Morioka, Cintia Yoko|Saito, Seiji|Machado, Marcel Cerqueira Cesar|Ohzawa, Kouji|Kubrusly, Marcia Saldanha|Cunha, Jose Eduardo Monteiro|Watanabe, Akiharu
PMID: 15113037
Journal: Cancer Gene Ther. 2004 Jul;11(7):465-76.
Title: Antiproliferative activity of a triplex-forming oligonucleotide recognizing a Ki-ras polypurine/polypyrimidine motif correlates with protein binding.
Author: Cogoi, Susanna|Ballico, Maurizio|Bonora, Gian-Maria|Xodo, Luigi E
PMID: 15118760
Journal: J Hepatobiliary Pancreat Surg. 2004;11(2):140-4.
Title: Clear cell carcinoma of the pancreas: an adenocarcinoma with unusual phenotype of duct cell origin.
Author: Sasaki, Atsushi|Ishio, Tetsuya|Bandoh, Toshio|Shibata, Kohei|Matsumoto, Toshifumi|Aramaki, Masanori|Kawano, Katsunori|Kitano, Seigo|Kashima, Kenji|Yokoyama, Shigeo
PMID: 15127279
Journal: Nihon Rinsho. 2004 May;62(5):889-93.
Title: [Alteration of the K-ras and p16/CDKN2 gene in endocrine pancreatic carcinomas].
Author: Shirahama, Shuya|Matsuyoshi, Junko|Yamamoto, Shigeki|Tsukada, Yutaka
PMID: 15148814
Journal: Br J Cancer. 2004 Jun 1;90(11):2243.
Title: Low value of detection of KRAS2 mutations in circulating DNA to differentiate chronic pancreatitis to pancreatic cancer.
Author: Marchese, R|Muleti, A|Brozzetti, S|Gandini, O|Brunetti, E|French, D
PMID: 15150585
Journal: Arch Pathol Lab Med. 2004 Jun;128(6):693-6.
Title: Clear cell ductal adenocarcinoma of pancreas: a case report and review of the literature.
Author: Ray, Sourav|Lu, Zhengbin|Rajendiran, Swaminathan
PMID: 15163226
Journal: Am J Surg Pathol. 2004 Jun;28(6):813-20.
Title: Ductuloinsular tumors of the pancreas: endocrine tumors with entrapped nonneoplastic ductules.
Author: van Eeden, Susanne|de Leng, Wendy W J|Offerhaus, G Johan A|Morsink, Folkert H|Weterman, Marian A J|de Krijger, Ronald R|Kloppel, Gunter|Klimstra, David S
PMID: 15166675
Journal: Endoscopy. 2004 Jun;36(6):535-42.
Title: Predictive factors for pancreatic cancer in patients with chronic pancreatitis in association with K-ras gene mutation.
Author: Arvanitakis, M|Van Laethem, J-L|Parma, J|De Maertelaer, V|Delhaye, M|Deviere, J
PMID: 15202051
Journal: J Gene Med. 2004 Oct;6(10):1139-48.
Title: Interferon-alpha and antisense K-ras RNA combination gene therapy against pancreatic cancer.
Author: Hatanaka, Kazuteru|Suzuki, Koichi|Miura, Yoshiaki|Yoshida, Kimiko|Ohnami, Shumpei|Kitade, Yukio|Yoshida, Teruhiko|Aoki, Kazunori
PMID: 15452878
Journal: Tokai J Exp Clin Med. 2004 Jun;29(2):35-42.
Title: An anti-K-ras ribozyme suppresses oncogene expression and cell growth of human pancreatic cancer.
Author: Sakuma, Toshiyuki|Kijima, Hiroshi|Nishi, Masatake|Abe, Yoshiyuki|Yamazaki, Hitoshi|Mine, Tetsuya|Nakamura, Masato|Ueyama, Yoshito
PMID: 15473338
Journal: Rev Med Chil. 2004 Aug;132(8):955-60.
Title: [K-ras gene mutation in gallbladder carcinoma].
Author: Roa, Juan Carlos|Roa, Ivan|de Aretxabala, Xabier|Melo, Angelica|Faria, Gaspar|Tapia, Oscar
PMID: 15478297
Journal: Nat Methods. 2004 Nov;1(2):141-7.
Title: LigAmp for sensitive detection of single-nucleotide differences.
Author: Shi, Chanjuan|Eshleman, Susan H|Jones, Dana|Fukushima, Noriyoshi|Hua, Li|Parker, Antony R|Yeo, Charles J|Hruban, Ralph H|Goggins, Michael G|Eshleman, James R
PMID: 15782177
Journal:
Title: (64)Cu-N,N'-Bis(S-benzoyl-thioglycoloyl)diaminopropanoate-KRAS-PNA-d(Cys-Ser-Lys- Cys)
Author: Cheng, Kenneth T.|Chakrabart, Atis|Aruva, Mohan R.|Thakur, Mathew L.|Wickstrom, Eric
PMID: 20641287
Journal:
Title: (99m)Tc-N,N'-Bis(S-benzoyl-thioglycoloyl)diamidopropanoyl-KRAS-PNA-d(Cys-Ser-Lys- Cys)
Author: Cheng, Kenneth T.|Chakrabarti, Atis|Aruva, Mohan R.|Thakur, Mathew L.|Wickstrom, Eric
PMID: 20641936
Journal: Cancer Cell. 2005 May;7(5):405-7.
Title: Chromosomal instability in mouse metastatic pancreatic cancer--it's Kras and Tp53 after all.
Author: Siveke, Jens T|Schmid, Roland M
PMID: 498881
Journal: Oncogene. 2005 Jan 20;24(4):585-96.
Title: Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis.
Author: Lebedeva, Irina V|Su, Zao-Zhong|Sarkar, Devanand|Gopalkrishnan, Rahul V|Waxman, Samuel|Yacoub, Adly|Dent, Paul|Fisher, Paul B
PMID: 15580305
Journal: Cancer Cell. 2005 Jan;7(1):39-49.
Title: Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis.
Author: Fernandez-Zapico, Martin E|Gonzalez-Paz, Natalia C|Weiss, Ellen|Savoy, Doris N|Molina, Julian R|Fonseca, Rafael|Smyrk, Thomas C|Chari, Suresh T|Urrutia, Raul|Billadeau, Daniel D
PMID: 15652748
Journal: Br J Cancer. 2005 Jan 31;92(2):405-12.
Title: Detection of Ki-ras mutations in tissue and plasma samples of patients with pancreatic cancer using PNA-mediated PCR clamping and hybridisation probes.
Author: Dabritz, J|Hanfler, J|Preston, R|Stieler, J|Oettle, H
PMID: 15655549
Journal: World J Gastroenterol. 2005 Apr 7;11(13):2026-31.
Title: Identification of effective siRNA against K-ras in human pancreatic cancer cell line MiaPaCa-2 by siRNA expression cassette.
Author: Wang, Wei|Wang, Chun-You|Dong, Ju-Hua|Chen, Xiong|Zhang, Min|Zhao, Gang
PMID: 15801000
Journal: Mod Pathol. 2005 Aug;18(8):1034-42.
Title: Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas.
Author: Furukawa, Toru|Fujisaki, Rumi|Yoshida, Yoshitaro|Kanai, Naomi|Sunamura, Makoto|Abe, Tadayoshi|Takeda, Kazunori|Matsuno, Seiki|Horii, Akira
PMID: 15832194
Journal: Cancer Biol Ther. 2005 May;4(5):548-54. Epub 2005 May 12.
Title: Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy.
Author: Embuscado, Erlinda E|Laheru, Daniel|Ricci, Francesca|Yun, Ki Jung|de Boom Witzel, Sten|Seigel, Allison|Flickinger, Katie|Hidalgo, Manuel|Bova, G Steven|Iacobuzio-Donahue, Christine A
PMID: 15846069
Journal: Gastroenterol Clin Biol. 2005 Apr;29(4):465-8.
Title: From pancreatic intraepithelial neoplasia to cancer: a dramatic progression with K-ras status analysis.
Author: Fernandez, Carla|Chetaille, Bruno|Tasei, Anne-Marie|Sastre, Bernard|Sahel, Jose|Payan-Defais, Marie-Jose
PMID: 15864214
Journal: In Vivo. 2005 May-Jun;19(3):535-8.
Title: Suppression of invasion of a hamster pancreatic cancer cell line by antisense oligonucleotides mutation-matched to K-ras gene.
Author: Morioka, Cintia Yoko|Machado, Marcel Cerqueira Cesar|Saito, Seiji|Nakada, Yuji|Matheus, Andre Siqueira|Jukemura, Jose|Bacchella, Telesforo|Takahara, Terumi|Watanabe, Akiharu
PMID: 15875772
Journal: Ai Zheng. 2005 May;24(5):559-62.
Title: [Anti-pancreatic cancer immune response induced by K-ras mutated peptide].
Author: He, Yang|Yang, Bo|Ruan, Chang-Geng
PMID: 15890097
Journal: Cancer Cell. 2005 May;7(5):405-7.
Title: Chromosomal instability in mouse metastatic pancreatic cancer--it's Kras and Tp53 after all.
Author: Siveke, Jens T|Schmid, Roland M
PMID: 15894260
Journal: Gan To Kagaku Ryoho. 2005 May;32(5):593-8.
Title: [Differential genetic pathway of duct and acinar carcinomas of the pancreas].
Author: Tsutsumi, Masahiro
PMID: 15918556
Journal: Genes Chromosomes Cancer. 2005 Sep;44(1):37-51.
Title: Analysis of genomic DNA alterations and mRNA expression patterns in a panel of human pancreatic cancer cell lines.
Author: Gysin, Stephan|Rickert, Paula|Kastury, Kumar|McMahon, Martin
PMID: 15929091
Journal: Praxis (Bern 1994). 2005 May 18;94(20):811-7.
Title: [Chronic pancreatitis--pancreas cancer: influence of genetic factors].
Author: Keim, V
PMID: 15957615
Journal: Cancer Res. 2005 Jun 15;65(12):5045-53.
Title: In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis.
Author: Qian, Jiaying|Niu, Jiangong|Li, Ming|Chiao, Paul J|Tsao, Ming-Sound
PMID: 15958547
Journal: Hepatogastroenterology. 2005 May-Jun;52(63):713-8.
Title: Ki-ras mutations in codon 12 and p53 mutations (biomarkers) and cytology in bile in patients with hepatobiliary-pancreatic carcinoma.
Author: Yamaguchi, Koji|Nakano, Kenji|Nagai, Eishi|Chijiiwa, Kazuo|Kinoshita, Moritoshi|Ohta, Masayuki|Tanaka, Masao
PMID: 15966189
Journal: Mol Cancer Res. 2005 Jul;3(7):413-23.
Title: Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy.
Author: Fleming, Jason B|Shen, Guo-Liang|Holloway, Shane E|Davis, Mishel|Brekken, Rolf A
PMID: 16046552
Journal: J Mol Diagn. 2005 Aug;7(3):413-21.
Title: Sensitive sequencing method for KRAS mutation detection by Pyrosequencing.
Author: Ogino, Shuji|Kawasaki, Takako|Brahmandam, Mohan|Yan, Liying|Cantor, Mami|Namgyal, Chungdak|Mino-Kenudson, Mari|Lauwers, Gregory Y|Loda, Massimo|Fuchs, Charles S
PMID: 16049314
Journal: Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 May;19(9):417-9.
Title: [The expressions of K-ras in human laryngeal squamous cell carcinoma cell lines (Hep-2) and its significance].
Author: Chen, Xiong|Kong, Weijia|Cai, Guanglian|Zhang, Sulin|Zhang, Dan
PMID: 16075979
Journal: Biochim Biophys Acta. 2005 Nov 25;1756(2):97-101.
Title: Mutant KRAS in the initiation of pancreatic cancer.
Author: Deramaudt, Therese|Rustgi, Anil K
PMID: 16169155
Journal: Semin Radiat Oncol. 2005 Oct;15(4):254-64.
Title: Ductal neoplasia of the pancreas: nosologic, clinicopathologic, and biologic aspects.
Author: Adsay, Nazmi Volkan|Basturk, Olca|Cheng, Jeanette D|Andea, Aleodor A
PMID: 16183479
Journal: Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):409-14.
Title: Synthesis of novel peptide nucleic acid-peptide chimera for non-invasive imaging of cancer.
Author: Chakrabarti, A|Aruva, M R|Sajankila, S P|Thakur, M L|Wickstrom, Eric
PMID: 16247960
Journal: Ann N Y Acad Sci. 2005 Nov;1059:106-44.
Title: External imaging of CCND1, MYC, and KRAS oncogene mRNAs with tumor-targeted radionuclide-PNA-peptide chimeras.
Author: Tian, Xiaobing|Chakrabarti, Atis|Amirkhanov, Nariman V|Aruva, Mohan R|Zhang, Kaijun|Mathew, Boby|Cardi, Christopher|Qin, Wenyi|Sauter, Edward R|Thakur, Mathew L|Wickstrom, Eric
PMID: 16382049
Journal: Rev Med Chil. 2005 Dec;133(12):1434-40. Epub 2006 Jan 27.
Title: [Frequency of K-ras mutation in biliary and pancreatic tumors].
Author: Roa, Juan Carlos|Anabalon, Leonardo|Tapia, Oscar|Melo, Angelica|de Aretxabala, Xabier|Roa, Ivan
PMID: 16446870
Journal: Cold Spring Harb Symp Quant Biol. 2005;70:65-72.
Title: Ductal pancreatic cancer in humans and mice.
Author: Tuveson, D A|Hingorani, S R
PMID: 16869739
Journal: Cell Signal. 2006 Aug;18(8):1156-68. Epub 2005 Oct 27.
Title: Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38.
Author: Dreissigacker, Ute|Mueller, Meike S|Unger, Monika|Siegert, Patrizia|Genze, Felicitas|Gierschik, Peter|Giehl, Klaudia
PMID: 16257181
Journal: Cancer Sci. 2006 Jan;97(1):1-7.
Title: Molecular mechanisms of pancreatic carcinogenesis.
Author: Furukawa, Toru|Sunamura, Makoto|Horii, Akira
PMID: 16367914
Journal: Cancer Res. 2006 Jan 1;66(1):242-7.
Title: Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma.
Author: Tuveson, David A|Zhu, Liqin|Gopinathan, Aarthi|Willis, Nicholas A|Kachatrian, Leili|Grochow, Rebecca|Pin, Christopher L|Mitin, Natalia Y|Taparowsky, Elizabeth J|Gimotty, Phyllis A|Hruban, Ralph H|Jacks, Tyler|Konieczny, Stephen F
PMID: 16397237
Journal: Nucleic Acids Res. 2006 Jan 23;34(2):e12.
Title: Detection of rare mutant K-ras DNA in a single-tube reaction using peptide nucleic acid as both PCR clamp and sensor probe.
Author: Luo, Ji-Dung|Chan, Err-Cheng|Shih, Chun-Liang|Chen, Tai-Long|Liang, Ying|Hwang, Tsann-Long|Chiou, Chiuan-Chian
PMID: 16432256
Journal: Oncogene. 2006 Aug 10;25(35):4831-9. Epub 2006 Mar 13.
Title: AURKA is one of the downstream targets of MAPK1/ERK2 in pancreatic cancer.
Author: Furukawa, T|Kanai, N|Shiwaku, H O|Soga, N|Uehara, A|Horii, A
PMID: 16532023
Journal: Best Pract Res Clin Gastroenterol. 2006 Apr;20(2):211-26.
Title: Molecular pathogenesis of pancreatic cancer.
Author: Maitra, Anirban|Kern, Scott E|Hruban, Ralph H
PMID: 16549325
Journal: Best Pract Res Clin Gastroenterol. 2006 Apr;20(2):285-98.
Title: Gene therapy developments for pancreatic cancer.
Author: Bhattacharyya, Madhumita|Lemoine, Nick R
PMID: 16549328
Journal: Virchows Arch. 2006 Jun;448(6):788-96.
Title: Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: lack of mutations in the BRAF and EGFR genes.
Author: Immervoll, Heike|Hoem, Dag|Kugarajh, Kalaiarasy|Steine, Solrun J|Molven, Anders
PMID: 16598499
Journal: Gut. 2006 Nov;55(11):1598-605. Epub 2006 May 8.
Title: Unfavourable prognosis associated with K-ras gene mutation in pancreatic cancer surgical margins.
Author: Kim, J|Reber, H A|Dry, S M|Elashoff, D|Chen, S L|Umetani, N|Kitago, M|Hines, O J|Kazanjian, K K|Hiramatsu, S|Bilchik, A J|Yong, S|Shoup, M|Hoon, D S B
PMID: 16682430
Journal: Mol Cell Biol. 2006 Jun;26(11):4185-200.
Title: N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruption.
Author: Deramaudt, Therese B|Takaoka, Munenori|Upadhyay, Rabi|Bowser, Mark J|Porter, Jess|Lee, Amy|Rhoades, Ben|Johnstone, Cameron N|Weissleder, Ralph|Hingorani, Sunil R|Mahmood, Umar|Rustgi, Anil K
PMID: 16705170
Journal: Clin Cancer Res. 2006 May 15;12(10):3152-7.
Title: Effective treatment of pancreatic cancer xenografts with a conditionally replicating virus derived from type 2 herpes simplex virus.
Author: Fu, Xinping|Tao, Lihua|Li, Min|Fisher, William E|Zhang, Xiaoliu
PMID: 16707615
Journal: Methods Enzymol. 2006;407:676-90.
Title: Physiological analysis of oncogenic K-ras.
Author: Perez-Mancera, Pedro Antonio|Tuveson, David A
PMID: 16757361
Journal: Chin J Dig Dis. 2006;7(3):170-4.
Title: Evaluation of the diagnostic value of serum tumor markers, and fecal k-ras and p53 gene mutations for pancreatic cancer.
Author: Wu, Xi|Lu, Xing Hua|Xu, Tong|Qian, Jia Ming|Zhao, Ping|Guo, Xiao Zhong|Yang, Xiao Ou|Jiang, Wei Jun
PMID: 16808798
Journal: Drugs Aging. 2006;23(5):403-10.
Title: Current treatment strategies for pancreatic cancer in the elderly.
Author: Hanada, Keiji|Hino, Fumiaki|Amano, Hajime|Fukuda, Toshikatsu|Kuroda, Yoshinori
PMID: 16823993
Journal: Am J Surg Pathol. 2006 Sep;30(9):1067-76.
Title: Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer.
Author: Brune, Kieran|Abe, Tadayoshi|Canto, Marcia|O'Malley, Lauren|Klein, Alison P|Maitra, Anirban|Volkan Adsay, N|Fishman, Elliot K|Cameron, John L|Yeo, Charles J|Kern, Scott E|Goggins, Michael|Hruban, Ralph H
PMID: 16931950
Journal: Neoplasma. 2006;53(5):363-71.
Title: Assay design and optimization of mutant-enriched PCR based method for detection of K-ras gene mutations in pancreatic carcinoma.
Author: Ugorcakova, J|Hlavaty, T|Babal, P|Janega, P|Bukovska, G|Halgasova, N|Hlavata, A|Timko, J|Duris, I
PMID: 17013530
Journal: Genes Dev. 2006 Nov 15;20(22):3130-46.
Title: Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.
Author: Bardeesy, Nabeel|Cheng, Kuang-Hung|Berger, Justin H|Chu, Gerald C|Pahler, Jessica|Olson, Peter|Hezel, Aram F|Horner, James|Lauwers, Gregory Y|Hanahan, Douglas|DePinho, Ronald A
PMID: 17114584
Journal: Int J Gastrointest Cancer. 2006;37(4):139-45.
Title: The association between selected risk factors for pancreatic cancer and the expression of p53 and K-ras codon 12 mutations.
Author: Fryzek, Jon P|Garabrant, David H|Schenk, Maryjean|Kinnard, Margaret|Greenson, Joel K|Sarkar, Fazlul H
PMID: 18049799
Journal: Cancer Lett. 2007 May 8;249(2):242-8.
Title: BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas.
Author: Schonleben, Frank|Qiu, Wanglong|Bruckman, Karl C|Ciau, Nancy T|Li, Xiaojun|Lauerman, Margaret H|Frucht, Harold|Chabot, John A|Allendorf, John D|Remotti, Helen E|Su, Gloria H
PMID: 17097223
Journal: Oncol Rep. 2007 Feb;17(2):399-407.
Title: Expression analysis of pancreatic cancer cell lines reveals association of enhanced gene transcription and genomic amplifications at the 8q22.1 and 8q24.22 loci.
Author: Domagk, Dirk|Schaefer, Karl-Ludwig|Eisenacher, Martin|Braun, Yvonne|Wai, Daniel H|Schleicher, Christina|Diallo-Danebrock, Raihanatou|Bojar, Hans|Roeder, Gernot|Gabbert, Helmut E|Domschke, Wolfram|Poremba, Christopher
PMID: 17203180
Journal: Cancer Res. 2007 Mar 1;67(5):2098-106.
Title: K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling.
Author: Campbell, Paul M|Groehler, Angela L|Lee, Kwang M|Ouellette, Michel M|Khazak, Vladimir|Der, Channing J
PMID: 17332339
Journal: Cancer Cell. 2007 Mar;11(3):211-3.
Title: A case of mistaken identity? Nonductal origins of pancreatic "ductal" cancers.
Author: Murtaugh, L Charles|Leach, Steven D
PMID: 17349578
Journal: Cancer Cell. 2007 Mar;11(3):229-43.
Title: Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas.
Author: Izeradjene, Kamel|Combs, Chelsea|Best, Melissa|Gopinathan, Aarthi|Wagner, Amary|Grady, William M|Deng, Chu-Xia|Hruban, Ralph H|Adsay, N Volkan|Tuveson, David A|Hingorani, Sunil R
PMID: 17349581
Journal: J Biol Chem. 2007 May 11;282(19):14048-55. Epub 2007 Mar 12.
Title: Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells.
Author: Ji, Zhenyu|Mei, Fang C|Xie, Jingwu|Cheng, Xiaodong
PMID: 17353198
Journal: Cancer. 2007 Apr 15;109(8):1561-9.
Title: Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma.
Author: Lee, Jeeyun|Jang, Kee-Taek|Ki, Chang-Seok|Lim, Taekyu|Park, Young Suk|Lim, Ho Yeong|Choi, Dong-Wook|Kang, Won Ki|Park, Keunchil|Park, Joon Oh
PMID: 17354229
Journal: Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Mar;38(2):309-11, 327.
Title: [Experiment study on the diagnostic value of bile K-ras gene mutation responsible to the hepatic metastasis of pancreatic cancer].
Author: Zhou, Xiang|Zhang, Zhao-Da|Tian, Bo-Le|Han, Fang-Hai|Hu, Wei-Ming|Jia, Wei|Lu, Hui-Ming
PMID: 17441357
Journal: Cancer Sci. 2007 Jul;98(7):1128-36.
Title: K-ras oncogene silencing strategy reduces tumor growth and enhances gemcitabine chemotherapy efficacy for pancreatic cancer treatment.
Author: Rejiba, Soukaina|Wack, Severine|Aprahamian, Marc|Hajri, Amor
PMID: 17489984
Journal: J Hepatobiliary Pancreat Surg. 2007;14(3):224-32. Epub 2007 May 29.
Title: Molecular genetics of pancreatic intraepithelial neoplasia.
Author: Feldmann, Georg|Beaty, Robert|Hruban, Ralph H|Maitra, Anirban
PMID: 17520196
Journal: J Hepatobiliary Pancreat Surg. 2007;14(3):238-42.
Title: Mucinous cystic neoplasms of the pancreas: pathology and molecular genetics.
Author: Fukushima, Noriyoshi|Fukayama, Masashi
PMID: 17520198
Journal: Cancer Biol Ther. 2007 Jun;6(6):948-56. Epub 2007 Mar 26.
Title: Radiohybridization PET imaging of KRAS G12D mRNA expression in human pancreas cancer xenografts with [(64)Cu]DO3A-peptide nucleic acid-peptide nanoparticles.
Author: Chakrabarti, A|Zhang, K|Aruva, M R|Cardi, C A|Opitz, A W|Wagner, N J|Thakur, M L|Wickstrom, E
PMID: 17611392
Journal: Carcinogenesis. 2007 Nov;28(11):2321-7. Epub 2007 Jul 17.
Title: RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells.
Author: Chow, Jimmy Y C|Quach, Khai T|Cabrera, Betty L|Cabral, Jennifer A|Beck, Stayce E|Carethers, John M
PMID: 17638924
Journal: Cancer Res. 2007 Aug 1;67(15):7068-71.
Title: Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor.
Author: Funahashi, Hitoshi|Satake, Makoto|Dawson, David|Huynh, Ngoc-An|Reber, Howard A|Hines, Oscar J|Eibl, Guido
PMID: 17652141
Journal: Cancer Res. 2007 Aug 1;67(15):7247-55.
Title: The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer.
Author: Jin, Kideok|Park, Sunju|Ewton, Daina Z|Friedman, Eileen
PMID: 17671193
Journal: Cancer Cell. 2007 Sep;12(3):266-79.
Title: Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.
Author: Siveke, Jens T|Einwachter, Henrik|Sipos, Bence|Lubeseder-Martellato, Clara|Kloppel, Gunter|Schmid, Roland M
PMID: 17785207
Journal: J Gastrointest Surg. 2007 Dec;11(12):1598-605; discussion 1605-6. Epub 2007 Sep
Title: Detection of micrometastases in peritoneal washings of pancreatic cancer patients by the reverse transcriptase polymerase chain reaction.
Author: Dalal, Kimberly Moore|Woo, Yanghee|Galanis, Charles|Gonen, Mithat|Tang, Laura|Allen, Peter|DeMatteo, Ronald|Fong, Yuman|Coit, Daniel G
PMID: 17879123
Journal: PLoS One. 2007 Nov 7;2(11):e1155.
Title: Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.
Author: Pasca di Magliano, Marina|Biankin, Andrew V|Heiser, Patrick W|Cano, David A|Gutierrez, Pedro J A|Deramaudt, Therese|Segara, Davendra|Dawson, Amanda C|Kench, James G|Henshall, Susan M|Sutherland, Robert L|Dlugosz, Andrzej|Rustgi, Anil K|Hebrok, Matthias
PMID: 17982507
Journal: J Clin Gastroenterol. 2007 Nov-Dec;41(10):906-10.
Title: Kras mutation analysis of fine needle aspirate under EUS guidance facilitates risk stratification of patients with pancreatic mass.
Author: Maluf-Filho, Fauze|Kumar, Atul|Gerhardt, Rene|Kubrusly, Marcia|Sakai, Paulo|Hondo, Fabio|Matuguma, Sergio Eiji|Artifon, Everson|Monteiro da Cunha, Jose Eduardo|Cesar Machado, Marcel Cerqueira|Ishioka, Shinichi|Forero, Elias
PMID: 18090159
Journal: Hum Mutat. 2008 Feb;29(2):284-8.
Title: PIK3CA cancer mutations display gender and tissue specificity patterns.
Author: Benvenuti, Silvia|Frattini, Milo|Arena, Sabrina|Zanon, Carlo|Cappelletti, Vera|Coradini, Danila|Daidone, Maria Grazia|Pilotti, Silvana|Pierotti, Marco A|Bardelli, Alberto
PMID: 18022911
Journal: Annu Rev Pathol. 2008;3:157-88.
Title: Pancreatic cancer.
Author: Maitra, Anirban|Hruban, Ralph H
PMID: 18039136
Journal: Genes Chromosomes Cancer. 2008 Mar;47(3):253-9.
Title: SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients.
Author: Swanson, Kenneth D|Winter, Jordan M|Reis, Marcelo|Bentires-Alj, Mohamed|Greulich, Heidi|Grewal, Rupinder|Hruban, Ralph H|Yeo, Charles J|Yassin, Yosuf|Iartchouk, Oleg|Montgomery, Kate|Whitman, Susan P|Caligiuri, Michael A|Loh, Mignon L|Gilliland, D Gary|Lo
PMID: 18064648
Journal: Cancer Biol Ther. 2008 Mar;7(3):353-360.
Title: Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection.
Author: Shi, Chanjuan|Fukushima, Noriyoshi|Abe, Tadayoshi|Bian, Yansong|Hua, Li|Wendelburg, Brian J|Yeo, Charles J|Hruban, Ralph H|Goggins, Michael G|Eshleman, James R
PMID: 18075308
Journal: Langenbecks Arch Surg. 2008 Nov;393(6):883-90.
Title: Molecular markers of pancreatic cancer: development and clinical relevance.
Author: Fry, Lucia C|Monkemuller, Klaus|Malfertheiner, Peter
PMID: 18266003
Journal: Langenbecks Arch Surg. 2008 May;393(3):289-96.
Title: PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/C) of the pancreas.
Author: Schonleben, Frank|Qiu, Wanglong|Remotti, Helen E|Hohenberger, Werner|Su, Gloria H
PMID: 18343945
Journal: J Hepatobiliary Pancreat Surg. 2008;15(2):169-77.
Title: Characterization of K-ras gene mutations in association with mucinous hypersecretion in intraductal papillary-mucinous neoplasms.
Author: Kobayashi, Noritoshi|Inamori, Masahiko|Fujita, Koji|Fujisawa, Toshio|Fujisawa, Nobutaka|Takahashi, Hirokazu|Yoneda, Masato|Abe, Yasunobu|Kawamura, Harunobu|Shimamura, Takeshi|Kirikoshi, Hiroyuki|Kubota, Kensuke|Sakaguchi, Takashi|Saito, Satoru|Saubermann,
PMID: 18392710
Journal: Methods Enzymol. 2008;438:391-417.
Title: Characterization of Kras-mediated pancreatic tumorigenesis in zebrafish.
Author: Davison, Jon M|Woo Park, Seung|Rhee, Jerry M|Leach, Steven D
PMID: 18413263
Journal: Cancer Res. 2008 Apr 15;68(8):2841-9.
Title: Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer.
Author: Jimeno, Antonio|Tan, Aik Choon|Coffa, Jordy|Rajeshkumar, N V|Kulesza, Peter|Rubio-Viqueira, Belen|Wheelhouse, Jenna|Diosdado, Begona|Messersmith, Wells A|Iacobuzio-Donahue, Christine|Maitra, Anirban|Varella-Garcia, Marileila|Hirsch, Fred R|Meijer, Gerrit
PMID: 18413752
Journal: Clin Cancer Res. 2008 Apr 15;14(8):2249-52.
Title: Targeting Ras in myeloid leukemias.
Author: Braun, Benjamin S|Shannon, Kevin
PMID: 18413813
Journal: Ai Zheng. 2008 May;27(5):496-504.
Title: [Combinational effects of K-ras and IGF-IR antisense oligodeoxynucleotide on proliferation and apoptosis of human pancreatic cancer Patu8988 cells].
Author: Shen, Yong-Mei|Yang, Xiao-Chun|Zhang, Mei-Hua|Shen, Jun-Kang|Sun, Yi-Hui
PMID: 18479599
Journal: Hum Pathol. 2008 Jul;39(7):1002-10.
Title: Prognostic significance of immunohistochemical RhoA expression on survival in pancreatic ductal adenocarcinoma: a high-throughput analysis.
Author: Dittert, Dag-Daniel|Kielisch, Christian|Alldinger, Ingo|Zietz, Christian|Meyer, Wolfdietrich|Dobrowolski, Frank|Saeger, Hans-Detlev|Baretton, Gustavo Bruno
PMID: 18495213
Journal: Gut. 2008 Oct;57(10):1420-30.
Title: Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer.
Author: Feldmann, G|Habbe, N|Dhara, S|Bisht, S|Alvarez, H|Fendrich, V|Beaty, R|Mullendore, M|Karikari, C|Bardeesy, N|Ouellette, M M|Yu, W|Maitra, A
PMID: 18515410
Journal: Curr Opin Oncol. 2008 Jul;20(4):454-8.
Title: Lessons from Tarceva in pancreatic cancer: where are we now, and how should future trials be designed in pancreatic cancer?
Author: Laurent-Puig, Pierre|Taieb, Julien
PMID: 18525343
Journal: Bull Cancer. 2008 May;95(5):503-12.
Title: [New molecular targets in pancreatic cancer].
Author: Torrisani, Jerome|Bournet, Barbara|Cordelier, Pierre|Buscail, Louis
PMID: 18541514
Journal: Gastroenterology. 2008 Jun;134(7):2080-90.
Title: Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas.
Author: Park, Seung Woo|Davison, Jon M|Rhee, Jerry|Hruban, Ralph H|Maitra, Anirban|Leach, Steven D
PMID: 18549880
Journal: Comp Med. 2008 Jun;58(3):271-5.
Title: Spontaneous vulvar papillomas in a colony of mice used for pancreatic cancer research.
Author: Gades, Naomi M|Ohash, Akihiro|Mills, Lisa D|Rowley, Matt A|Predmore, Kelly S|Marler, Ronald J|Couch, Fergus J
PMID: 18589869
Journal: Cancer Biol Ther. 2008 Mar;7(3):361-3.
Title: Shining the spotlight on shed KRAS in pancreatic cancer.
Author: Sempere, Lorenzo F|Korc, Murray
PMID: 18614859
Journal: Gastroenterology. 2008 Oct;135(4):1288-300.
Title: Stabilization of beta-catenin induces pancreas tumor formation.
Author: Heiser, Patrick W|Cano, David A|Landsman, Limor|Kim, Grace E|Kench, James G|Klimstra, David S|Taketo, Maketo M|Biankin, Andrew V|Hebrok, Matthias
PMID: 18725219
Journal: World J Gastroenterol. 2008 Sep 7;14(33):5176-85.
Title: Enhanced therapeutic effects for human pancreatic cancer by application K-ras and IGF-IR antisense oligodeoxynucleotides.
Author: Shen, Yong-Mei|Yang, Xiao-Chun|Yang, Chen|Shen, Jun-Kang
PMID: 18777594
Journal: Cancer Res. 2008 Oct 1;68(19):7723-9.
Title: SCL/TAL1 interrupting locus derepresses GLI1 from the negative control of suppressor-of-fused in pancreatic cancer cell.
Author: Kasai, Kenji|Inaguma, Shingo|Yoneyama, Akiko|Yoshikawa, Kazuhiro|Ikeda, Hiroshi
PMID: 18829525
Journal: J Mol Diagn. 2008 Nov;10(6):520-6.
Title: Rapid screening assay for KRAS mutations by the modified smart amplification process.
Author: Tatsumi, Kenji|Mitani, Yasumasa|Watanabe, Jun|Takakura, Hideki|Hoshi, Kanako|Kawai, Yuki|Kikuchi, Takeshi|Kogo, Yasushi|Oguchi-Katayama, Atsuko|Tomaru, Yasuhiro|Kanamori, Hajime|Baba, Masaru|Ishidao, Takefumi|Usui, Kengo|Itoh, Masayoshi|Cizdziel, Paul E|L
PMID: 18832461
Journal: Cancer Biol Ther. 2008 Nov;7(11):1793-802. Epub 2008 Nov 21.
Title: Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification.
Author: Chen, Shuaili|Auletta, Theresa|Dovirak, Ostap|Hutter, Christina|Kuntz, Karen|El-ftesi, Samira|Kendall, Jude|Han, Haiyong|Von Hoff, Daniel D|Ashfaq, Raheela|Maitra, Anirban|Iacobuzio-Donahue, Christine A|Hruban, Ralph H|Lucito, Robert
PMID: 18836286
Journal: Digestion. 2008;78(1):60-5.
Title: Histopathological features of patients with chronic pancreatitis due to mutations in the PRSS1 gene: evaluation of BRAF and KRAS2 mutations.
Author: Felderbauer, Peter|Stricker, Ingo|Schnekenburger, Jurgen|Bulut, Kerem|Chromik, Ansgar M|Belyaev, Orlin|Muller, Christophe A|Uhl, Waldemar|Tannapfel, Andrea|Schmidt, Wolfgang E
PMID: 18946221
Journal: Tumour Biol. 2008;29(6):343-50.
Title: Total number of genome alterations in sporadic gastrointestinal cancer inferred from pooled analyses in the literature.
Author: Nishimura, Takafumi
PMID: 19023234
Journal: Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18907-12.
Title: Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia.
Author: De La O, Jean-Paul|Emerson, Lyska L|Goodman, Jessica L|Froebe, Scott C|Illum, Benjamin E|Curtis, Andrew B|Murtaugh, L Charles
PMID: 19028876
Journal: Zhonghua Yi Xue Za Zhi. 2008 Jul 22;88(28):1956-60.
Title: [Specific immune against pancreatic cancer induced by dendritic cells pulsed with mutant K-ras peptide].
Author: Yang, Bo|He, Yang|Sun, Dong-lin|Zou, Yan|Qin, Xi-hu|Huang, Bo-hua
PMID: 19062734
Journal: Gut Liver. 2008 Dec;2(3):137-54.
Title: Precursor lesions of pancreatic cancer.
Author: Yonezawa, Suguru|Higashi, Michiyo|Yamada, Norishige|Goto, Masamichi
PMID: 20485640
Journal: Cancer Gene Ther. 2009 Mar;16(3):227-36.
Title: Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo.
Author: Shi, X H|Liang, Z Y|Ren, X Y|Liu, T H
PMID: 18949011
Journal: J Med Chem. 2009 Jan 22;52(2):564-8.
Title: Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells.
Author: Cogoi, Susanna|Paramasivam, Manikandan|Filichev, Vyacheslav|Geci, Imrich|Pedersen, Erik B|Xodo, Luigi E
PMID: 19099510
Journal: J Immunol. 2009 Jan 1;182(1):216-24.
Title: Progression of pancreatic adenocarcinoma is significantly impeded with a combination of vaccine and COX-2 inhibition.
Author: Mukherjee, Pinku|Basu, Gargi D|Tinder, Teresa L|Subramani, Durai B|Bradley, Judy M|Arefayene, Million|Skaar, Todd|De Petris, Giovanni
PMID: 19109152
Journal: Pancreas. 2009 Jan;38(1):85-93.
Title: Gene expression profiling of adenosine triphosphate-binding cassette transporters in response to K-ras activation and hypoxia in human pancreatic cancer cell cultures.
Author: Lo, Maisie|Tsao, Ming-Sound|Hedley, David|Ling, Victor
PMID: 19117087
Journal: Genes Dev. 2009 Jan 1;23(1):24-36.
Title: GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.
Author: Nolan-Stevaux, Olivier|Lau, Janet|Truitt, Morgan L|Chu, Gerald C|Hebrok, Matthias|Fernandez-Zapico, Martin E|Hanahan, Douglas
PMID: 19136624
Journal: Cancer Res. 2009 Jan 15;69(2):422-30.
Title: Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia.
Author: Seeley, E Scott|Carriere, Catherine|Goetze, Tobias|Longnecker, Daniel S|Korc, Murray
PMID: 19147554
Journal: Mol Cancer Res. 2009 Feb;7(2):230-6.
Title: KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin.
Author: Shi, Chanjuan|Hong, Seung-Mo|Lim, Phillip|Kamiyama, Hirohiko|Khan, Mehtab|Anders, Robert A|Goggins, Michael|Hruban, Ralph H|Eshleman, James R
PMID: 19208745
Journal: J Hematol Oncol. 2009 Feb 23;2:9.
Title: Updates in Gastrointestinal Oncology - insights from the 2008 44th annual meeting of the American Society of Clinical Oncology.
Author: Javle, Milind|Hsueh, Chung-Tsen
PMID: 19236713
Journal: Gastroenterology. 2009 Apr;136(4):1368-78.
Title: Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia.
Author: Shi, Guanglu|Zhu, Liqin|Sun, Yan|Bettencourt, Ryan|Damsz, Barbara|Hruban, Ralph H|Konieczny, Stephen F
PMID: 19249398
Journal: Biochem Biophys Res Commun. 2009 Apr 17;381(4):706-11.
Title: Comparison of ras-responsive gene enhancers in pancreatic tumor cells that express either wild-type or mutant K-ras.
Author: Wilder, Phillip J|Chakravarthy, Harini|Hollingsworth, Michael A|Rizzino, Angie
PMID: 19254697
Journal: Mod Pathol. 2009 May;22(5):651-9.
Title: Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma.
Author: Brody, Jonathan R|Costantino, Christina L|Potoczek, Magdalena|Cozzitorto, Joseph|McCue, Peter|Yeo, Charles J|Hruban, Ralph H|Witkiewicz, Agnieszka K
PMID: 19270646
Journal: Front Biosci (Landmark Ed). 2009 Jan 1;14:2904-10.
Title: Chemical genetic screening of KRAS-based synthetic lethal inhibitors for pancreatic cancer.
Author: Ji, Zhenyu|Mei, Fang C|Lory, Pedro L|Gilbertson, Scott R|Chen, Yijun|Cheng, Xiaodong
PMID: 19273243
Journal: J Clin Oncol. 2009 Apr 10;27(11):1806-13.
Title: DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer.
Author: Iacobuzio-Donahue, Christine A|Fu, Baojin|Yachida, Shinichi|Luo, Mingde|Abe, Hisashi|Henderson, Clark M|Vilardell, Felip|Wang, Zheng|Keller, Jesse W|Banerjee, Priya|Herman, Joseph M|Cameron, John L|Yeo, Charles J|Halushka, Marc K|Eshleman, James R|Raben,
PMID: 19273710
Journal: Biochem Biophys Res Commun. 2009 May 8;382(3):561-5.
Title: Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras.
Author: Carriere, Catherine|Young, Alison L|Gunn, Jason R|Longnecker, Daniel S|Korc, Murray
PMID: 19292977
Journal: Hum Gene Ther. 2009 Aug;20(8):831-44.
Title: let-7 MicroRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression.
Author: Torrisani, Jerome|Bournet, Barbara|du Rieu, Mael Chalret|Bouisson, Michele|Souque, Anny|Escourrou, Jean|Buscail, Louis|Cordelier, Pierre
PMID: 19323605
Journal: Cancer Res. 2009 Apr 15;69(8):3681-8.
Title: Genetic mutations associated with cigarette smoking in pancreatic cancer.
Author: Blackford, Amanda|Parmigiani, Giovanni|Kensler, Thomas W|Wolfgang, Christopher|Jones, Sian|Zhang, Xiaosong|Parsons, D Willams|Lin, Jimmy Cheng-Ho|Leary, Rebecca J|Eshleman, James R|Goggins, Michael|Jaffee, Elizabeth M|Iacobuzio-Donahue, Christine A|Maitra
PMID: 19351817
Journal: Gastroenterology. 2009 Jul;137(1):361-71, 371.e1-5.
Title: E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex.
Author: von Burstin, Johannes|Eser, Stefan|Paul, Mariel C|Seidler, Barbara|Brandl, Martina|Messer, Marlena|von Werder, Alexander|Schmidt, Annegret|Mages, Jorg|Pagel, Philipp|Schnieke, Angelika|Schmid, Roland M|Schneider, Gunter|Saur, Dieter
PMID: 19362090
Journal: Mol Cancer Ther. 2009 Apr;8(4):834-43.
Title: KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer.
Author: Yeh, Jen Jen|Routh, Elizabeth D|Rubinas, Tara|Peacock, Janie|Martin, Timothy D|Shen, Xiang Jun|Sandler, Robert S|Kim, Hong Jin|Keku, Temitope O|Der, Channing J
PMID: 19372556
Journal: Anticancer Drugs. 2009 Aug;20(7):634-8.
Title: Prolonged survival in a patient with BRCA2 associated metastatic pancreatic cancer after exposure to camptothecin: a case report and review of literature.
Author: James, Edward|Waldron-Lynch, Maeve G|Saif, Muhammad Wasif
PMID: 19433978
Journal: Cell Cycle. 2009 Jun 15;8(12):1860-4.
Title: Notch and Kras in pancreatic cancer: at the crossroads of mutation, differentiation and signaling.
Author: De La O, Jean-Paul|Murtaugh, L Charles
PMID: 19440048
Journal: Am J Surg Pathol. 2009 Aug;33(8):1164-72.
Title: Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms.
Author: Yamaguchi, Hiroshi|Shimizu, Michio|Ban, Shinichi|Koyama, Isamu|Hatori, Takashi|Fujita, Izumi|Yamamoto, Masakazu|Kawamura, Shunji|Kobayashi, Makio|Ishida, Kazuyuki|Morikawa, Takanori|Motoi, Fuyuhiko|Unno, Michiaki|Kanno, Atsushi|Satoh, Kennichi|Shimosegawa
PMID: 19440145
Journal: J Mol Diagn. 2009 Jul;11(4):290-7.
Title: A tumor sorting protocol that enables enrichment of pancreatic adenocarcinoma cells and facilitation of genetic analyses.
Author: Boyd, Zachary S|Raja, Rajiv|Johnson, Stephanie|Eberhard, David A|Lackner, Mark R
PMID: 19460940
Journal: Mol Cancer Res. 2009 Jun;7(6):799-808.
Title: K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways.
Author: Matsuo, Yoichi|Campbell, Paul M|Brekken, Rolf A|Sung, Bokyung|Ouellette, Michel M|Fleming, Jason B|Aggarwal, Bharat B|Der, Channing J|Guha, Sushovan
PMID: 19509115
Journal: Endoscopy. 2009 Jun;41(6):552-7.
Title: Endoscopic ultrasound-guided fine-needle aspiration biopsy coupled with KRAS mutation assay to distinguish pancreatic cancer from pseudotumoral chronic pancreatitis.
Author: Bournet, B|Souque, A|Senesse, P|Assenat, E|Barthet, M|Lesavre, N|Aubert, A|O'Toole, D|Hammel, P|Levy, P|Ruszniewski, P|Bouisson, M|Escourrou, J|Cordelier, P|Buscail, L
PMID: 19533561
Journal: JOP. 2009 Jul 6;10(4):357-60.
Title: Pharmacogenetics in pancreatic cancer. Highlights from the 45th ASCO annual meeting. Orlando, FL, USA. May 29-June 2, 2009.
Author: Strimpakos, Alexios S|Syrigos, Kostas N|Saif, Muhammad Wasif
PMID: 19581734
Journal: PLoS Genet. 2009 Jul;5(7):e1000575.
Title: Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas.
Author: Vincent, David F|Yan, Kai-Ping|Treilleux, Isabelle|Gay, Fabien|Arfi, Vanessa|Kaniewski, Bastien|Marie, Julien C|Lepinasse, Florian|Martel, Sylvie|Goddard-Leon, Sophie|Iovanna, Juan L|Dubus, Pierre|Garcia, Stephane|Puisieux, Alain|Rimokh, Ruth|Bardeesy, Na
PMID: 19629168
Journal: Mol Cancer Res. 2009 Aug;7(8):1390-8.
Title: Up-regulation of Kruppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha.
Author: Mori, Akira|Moser, Christian|Lang, Sven A|Hackl, Christina|Gottfried, Eva|Kreutz, Marina|Schlitt, Hans J|Geissler, Edward K|Stoeltzing, Oliver
PMID: 19671674
Journal: Biochem Biophys Res Commun. 2009 Dec 18;390(3):636-41.
Title: An animal model of preclinical diagnosis of pancreatic ductal adenocarcinomas.
Author: Fukamachi, Katsumi|Tanaka, Hajime|Hagiwara, Yoshiaki|Ohara, Hirotaka|Joh, Takashi|Iigo, Masaaki|Alexander, David B|Xu, Jiegou|Long, Ne|Takigahira, Misato|Yanagihara, Kazuyoshi|Hino, Okio|Saito, Izumu|Tsuda, Hiroyuki
PMID: 19818733
Journal: Anticancer Drugs. 2009 Nov;20(10):851-5.
Title: Epidermal growth factor receptor inhibitors in cancer treatment: advances, challenges and opportunities.
Author: Modjtahedi, Helmout|Essapen, Sharadah
PMID: 19826350
Journal: PLoS One. 2009 Oct 14;4(10):e7464.
Title: Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells.
Author: Soh, Junichi|Okumura, Naoki|Lockwood, William W|Yamamoto, Hiromasa|Shigematsu, Hisayuki|Zhang, Wei|Chari, Raj|Shames, David S|Tang, Ximing|MacAulay, Calum|Varella-Garcia, Marileila|Vooder, Tonu|Wistuba, Ignacio I|Lam, Stephen|Brekken, Rolf|Toyooka, Shinic
PMID: 19826477
Journal: Pancreas. 2009 Oct;38(7):e200-6.
Title: Resequencing analysis of the human tyrosine kinase gene family in pancreatic cancer.
Author: Kubo, Takashi|Kuroda, Yukie|Kokubu, Akiko|Hosoda, Fumie|Arai, Yasuhito|Hiraoka, Nobuyoshi|Hirohashi, Setsuo|Shibata, Tatsuhiro
PMID: 19893451
Journal: Clin Gastroenterol Hepatol. 2009 Nov;7(11 Suppl):S35-9.
Title: Molecular pathology of pancreatic cancer: implications for molecular targeting therapy.
Author: Furukawa, Toru
PMID: 19896096
Journal: Cancer Res. 2009 Dec 15;69(24):9169-74.
Title: Tgfbr1 haploinsufficiency inhibits the development of murine mutant Kras-induced pancreatic precancer.
Author: Adrian, Kevin|Strouch, Matthew J|Zeng, Qinghua|Barron, Morgan R|Cheon, Eric C|Honasoge, Akilesh|Xu, Yanfei|Phukan, Sharbani|Sadim, Maureen|Bentrem, David J|Pasche, Boris|Grippo, Paul J
PMID: 19951995
Journal: Pancreatology. 2009;9(6):793-6.
Title: MUTYH exon 7 and 13 mutations associated with colorectal cancer (MAP syndrome) are not commonly associated with sporadic pancreatic cancer.
Author: Smith, Lauren M|Sharif, Saima|Brand, Randall|Fink, Erin|Lamb, Janette|Whitcomb, David C
PMID: 20110747
Journal: Int J Cancer. 2010 Jan 15;126(2):395-404.
Title: Increased expression of the heterogeneous nuclear ribonucleoprotein K in pancreatic cancer and its association with the mutant p53.
Author: Zhou, Renyuan|Shanas, Renee|Nelson, Mark A|Bhattacharyya, Achyut|Shi, Jiaqi
PMID: 19609950
Journal: Gut. 2010 May;59(5):630-7.
Title: The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer.
Author: Fendrich, Volker|Chen, Nai-Ming|Neef, Meike|Waldmann, Jens|Buchholz, Malte|Feldmann, Georg|Slater, Emily P|Maitra, Anirban|Bartsch, Detlef K
PMID: 19880966
Journal: Cancer Sci. 2010 Feb;101(2):341-6.
Title: Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats.
Author: Tanaka, Hajime|Fukamachi, Katsumi|Futakuchi, Mitsuru|Alexander, David B|Long, Ne|Tamamushi, Shojiro|Minami, Kohtaro|Seino, Susumu|Ohara, Hirotaka|Joh, Takashi|Tsuda, Hiroyuki
PMID: 19917056
Journal: Pancreas. 2010 Apr;39(3):308-14.
Title: Novel xenograft and cell line derived from an invasive intraductal papillary mucinous neoplasm of the pancreas give new insights into molecular mechanisms.
Author: Fritz, Stefan|Fernandez-del Castillo, Carlos|Iafrate, A John|Mino-Kenudson, Mari|Neyhard, Nancy|LaFemina, Jennifer|Stirman, Amy|Warshaw, Andrew L|Thayer, Sarah P
PMID: 19924021
Journal: Gastroenterology. 2010 Mar;138(3):949-57.e1-7.
Title: Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer.
Author: Zhang, Lei|Farrell, James J|Zhou, Hui|Elashoff, David|Akin, David|Park, No-Hee|Chia, David|Wong, David T
PMID: 19931263
Journal: J Mol Diagn. 2010 Jan;12(1):27-34.
Title: Sensitive and specific KRAS somatic mutation analysis on whole-genome amplified DNA from archival tissues.
Author: van Eijk, Ronald|van Puijenbroek, Marjo|Chhatta, Amiet R|Gupta, Nisha|Vossen, Rolf H A M|Lips, Esther H|Cleton-Jansen, Anne-Marie|Morreau, Hans|van Wezel, Tom
PMID: 19959798
Journal: Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):246-51.
Title: Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer.
Author: Morton, Jennifer P|Timpson, Paul|Karim, Saadia A|Ridgway, Rachel A|Athineos, Dimitris|Doyle, Brendan|Jamieson, Nigel B|Oien, Karin A|Lowy, Andrew M|Brunton, Valerie G|Frame, Margaret C|Evans, T R Jeffry|Sansom, Owen J
PMID: 20018721
Journal: J Clin Invest. 2010 Feb;120(2):508-20.
Title: Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice.
Author: Morris, John P 4th|Cano, David A|Sekine, Shigeki|Wang, Sam C|Hebrok, Matthias
PMID: 20071774
Journal: Clin Chem. 2010 Apr;56(4):603-12.
Title: MicroRNA-21 is induced early in pancreatic ductal adenocarcinoma precursor lesions.
Author: du Rieu, Mael Chalret|Torrisani, Jerome|Selves, Janick|Al Saati, Talal|Souque, Anny|Dufresne, Marlene|Tsongalis, Gregory J|Suriawinata, Arief A|Carrere, Nicolas|Buscail, Louis|Cordelier, Pierre
PMID: 20093556
Journal: Cancer Res. 2010 Mar 1;70(5):2064-74.
Title: Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis.
Author: Scotti, Michele L|Bamlet, William R|Smyrk, Thomas C|Fields, Alan P|Murray, Nicole R
PMID: 20179210
Journal: Am J Surg Pathol. 2010 Apr;34(4):510-8.
Title: Pancreatic acinar cell carcinomas with prominent ductal differentiation: Mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma.
Author: Stelow, Edward B|Shaco-Levy, Ruthy|Bao, Fei|Garcia, Joaquin|Klimstra, David S
PMID: 20182344
Journal: JOP. 2010 Mar 5;11(2):124-7.
Title: Translational research in pancreatic cancer. Highlights from the "2010 ASCO Gastrointestinal Cancers Symposium". Orlando, FL, USA. January 22-24, 2010.
Author: Strimpakos, Alexios S|Syrigos, Konstantinos N|Saif, Muhammad Wasif
PMID: 20208318
Journal: Bioconjug Chem. 2010 Apr 21;21(4):731-40.
Title: Imaging human pancreatic cancer xenografts by targeting mutant KRAS2 mRNA with [(111)In]DOTA(n)-poly(diamidopropanoyl)(m)-KRAS2 PNA-D(Cys-Ser-Lys-Cys) nanoparticles.
Author: Amirkhanov, Nariman V|Zhang, Kaijun|Aruva, Mohan R|Thakur, Mathew L|Wickstrom, Eric
PMID: 20232877
Journal: Pancreas. 2010 May;39(4):425-35.
Title: Phenotype and genotype of pancreatic cancer cell lines.
Author: Deer, Emily L|Gonzalez-Hernandez, Jessica|Coursen, Jill D|Shea, Jill E|Ngatia, Josephat|Scaife, Courtney L|Firpo, Matthew A|Mulvihill, Sean J
PMID: 20418756
Journal: World J Gastroenterol. 2010 Apr 28;16(16):1970-8.
Title: Molecular determinants of the antitumor effects of trichostatin A in pancreatic cancer cells.
Author: Emonds, Elisabeth|Fitzner, Brit|Jaster, Robert
PMID: 20419833
Journal: Expert Opin Ther Targets. 2010 Jun;14(6):611-20.
Title: PAR-4 as a possible new target for pancreatic cancer therapy.
Author: Azmi, Asfar S|Philip, Philip A|Zafar, Syed F|Sarkar, Fazlul H|Mohammad, Ramzi M
PMID: 20426700
Journal: Gastroenterology. 2010 Aug;139(2):586-97, 597.e1-6.
Title: LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest.
Author: Morton, Jennifer P|Jamieson, Nigel B|Karim, Saadia A|Athineos, Dimitris|Ridgway, Rachel A|Nixon, Colin|McKay, Colin J|Carter, Ross|Brunton, Valerie G|Frame, Margaret C|Ashworth, Alan|Oien, Karin A|Evans, T R Jeffry|Sansom, Owen J
PMID: 20452353
Journal: Pathol Int. 2010 May;60(5):358-64.
Title: Diagnostic approach to pancreatic tumors with the specimens of endoscopic ultrasound-guided fine needle aspiration.
Author: Hosoda, Waki|Takagi, Tadayuki|Mizuno, Nobumasa|Shimizu, Yasuhiro|Sano, Tsuyoshi|Yamao, Kenji|Yatabe, Yasushi
PMID: 20518885
Journal: Future Oncol. 2010 Jun;6(6):885-91.
Title: Salirasib in the treatment of pancreatic cancer.
Author: Bustinza-Linares, Ernesto|Kurzrock, Razelle|Tsimberidou, Apostolia-Maria
PMID: 20528225
Journal: Pancreas. 2010 Oct;39(7):1093-103.
Title: Genomic instability at both the base pair level and the chromosomal level is detectable in earliest PanIN lesions in tissues of chronic pancreatitis.
Author: Baumgart, Mario|Werther, Meike|Bockholt, Anke|Scheurer, Maria|Ruschoff, Josef|Dietmaier, Wolfgang|Ghadimi, B Michael|Heinmoller, Ernst
PMID: 20531246
Journal: Clin Cancer Res. 2010 Jul 15;16(14):3684-95.
Title: Development of an orthotopic model of invasive pancreatic cancer in an immunocompetent murine host.
Author: Tseng, William W|Winer, Daniel|Kenkel, Justin A|Choi, Okmi|Shain, Alan H|Pollack, Jonathan R|French, Randy|Lowy, Andrew M|Engleman, Edgar G
PMID: 20534740
Journal: Eur J Surg Oncol. 2010 Jul;36(7):657-62.
Title: K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer.
Author: Chen, H|Tu, H|Meng, Z Q|Chen, Z|Wang, P|Liu, L M
PMID: 20542658
Journal: Cancer Res. 2010 Jul 15;70(14):6015-25.
Title: miRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer.
Author: Yu, Shuangni|Lu, Zhaohui|Liu, Changzheng|Meng, Yunxiao|Ma, Yihui|Zhao, Wugan|Liu, Jianping|Yu, Jia|Chen, Jie
PMID: 20610624
Journal: Cancer Res. 2010 Aug 1;70(15):6283-92.
Title: Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors.
Author: Sasajima, Junpei|Mizukami, Yusuke|Sugiyama, Yoshiaki|Nakamura, Kazumasa|Kawamoto, Toru|Koizumi, Kazuya|Fujii, Rie|Motomura, Wataru|Sato, Kazuya|Suzuki, Yasuaki|Tanno, Satoshi|Fujiya, Mikihiro|Sasaki, Katsunori|Shimizu, Norihiko|Karasaki, Hidenori|Kono, To
PMID: 20631070
Journal: Biomark Med. 2010 Aug;4(4):535-41.
Title: Use of K-Ras as a predictive biomarker for selecting anti-EGF receptor/pathway treatment.
Author: Jiang, Yixing|Mackley, Heath|Cheng, Hua|Ajani, Jaffer A
PMID: 20701442
Journal: Pancreatology. 2010;10(4):429-33.
Title: DNA mutational differences in cytological specimens from pancreatic cancer and cholangiocarcinoma.
Author: Fasanella, Kenneth E|Krasinskas, Alyssa|Schoedel, Karen E|Sasatomi, Eizaburo|Slivka, Adam|Whitcomb, David C|Sanders, Michael|Nodit, Laurentia|Raab, Stephen|McGrath, Kevin M|Ohori, N Paul|Khalid, Asif
PMID: 20720444
Journal: Cancer Res. 2010 Sep 15;70(18):7114-24.
Title: PTEN loss accelerates KrasG12D-induced pancreatic cancer development.
Author: Hill, Reginald|Calvopina, Joseph Hargan|Kim, Christine|Wang, Ying|Dawson, David W|Donahue, Timothy R|Dry, Sarah|Wu, Hong
PMID: 20807812
Journal: Cancer. 2010 Dec 15;116(24):5599-607.
Title: Molecular predictors of outcome in a phase 3 study of gemcitabine and erlotinib therapy in patients with advanced pancreatic cancer: National Cancer Institute of Canada Clinical Trials Group Study PA.3.
Author: da Cunha Santos, Gilda|Dhani, Neesha|Tu, Dongsheng|Chin, Kayu|Ludkovski, Olga|Kamel-Reid, Suzanne|Squire, Jeremy|Parulekar, Wendy|Moore, Malcolm J|Tsao, Ming Sound
PMID: 20824720
Journal: Cancer Res. 2010 Nov 1;70(21):8398-406.
Title: Identification of susceptibility loci in a mouse model of KRASG12D-driven pancreatic cancer.
Author: Jorgenson, Tonia C|Williams, Bret R|Wendland, Allyson|Bilger, Andrea|Sandgren, Eric P|Drinkwater, Norman R
PMID: 20959479
Journal: Cancer Prev Res (Phila). 2010 Nov;3(11):1427-34.
Title: Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.
Author: Liby, Karen T|Royce, Darlene B|Risingsong, Renee|Williams, Charlotte R|Maitra, Anirban|Hruban, Ralph H|Sporn, Michael B
PMID: 20959520
Journal: J Mol Signal. 2010 Nov 2;5:18.
Title: TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling.
Author: Campbell, Paul M|Boufaied, Nadia|Fiordalisi, James J|Cox, Adrienne D|Falardeau, Pierre|Der, Channing J|Gourdeau, Henriette
PMID: 21044336
Journal: Cancer Cell. 2010 Nov 16;18(5):499-509.
Title: Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer.
Author: Skoulidis, Ferdinandos|Cassidy, Liam D|Pisupati, Venkat|Jonasson, Jon G|Bjarnason, Hordur|Eyfjord, Jorunn E|Karreth, Florian A|Lim, Michael|Barber, Lorraine M|Clatworthy, Susan A|Davies, Susan E|Olive, Kenneth P|Tuveson, David A|Venkitaraman, Ashok R
PMID: 21056012
Journal: Cancer Prev Res (Phila). 2010 Nov;3(11):1417-26.
Title: The epidermal growth factor receptor inhibitor gefitinib prevents the progression of pancreatic lesions to carcinoma in a conditional LSL-KrasG12D/+ transgenic mouse model.
Author: Mohammed, Altaf|Janakiram, Naveena B|Li, Qian|Madka, Venkateshwar|Ely, Misty|Lightfoot, Stan|Crawford, Howard|Steele, Vernon E|Rao, Chinthalapally V
PMID: 21084261
Journal: Genes Dev. 2010 Dec 15;24(24):2754-9.
Title: Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway.
Author: Kent, Oliver A|Chivukula, Raghu R|Mullendore, Michael|Wentzel, Erik A|Feldmann, Georg|Lee, Kwang H|Liu, Shu|Leach, Steven D|Maitra, Anirban|Mendell, Joshua T
PMID: 21159816
Journal: World J Gastrointest Surg. 2010 Oct 27;2(10):314-8.
Title: Population-based epidemiology, risk factors and screening of intraductal papillary mucinous neoplasm patients.
Author: Khan, Saboor|Sclabas, Guido|Reid-Lombardo, Kaye M
PMID: 21160836
Journal: Gastroenterol Res Pract. 2010;2010:789363.
Title: Analysis of KRAS Mutations of Exon 2 Codons 12 and 13 by SNaPshot Analysis in Comparison to Common DNA Sequencing.
Author: Zinsky, Rica|Bolukbas, Servet|Bartsch, Holger|Schirren, Joachim|Fisseler-Eckhoff, Annette
PMID: 21197450
Journal: Oncol Lett. 2010 Mar;1(2):231-235.
Title: Antitumor activity of erlotinib in combination with gemcitabine in in vitro and in vivo models of KRAS-mutated pancreatic cancers.
Author: Furugaki, Koh|Iwai, Toshiki|Kondoh, Kumiko|Moriya, Yoichiro|Mori, Kazushige
PMID: 22966286
Journal: Expert Opin Med Diagn. 2010 Sep;4(5):383-95.
Title: New and potential clinical applications of KRAS as a cancer biomarker.
Author: Kriegshauser, Gernot|Auner, Veronika|Zeillinger, Robert
PMID: 23496197
Journal: Cancers (Basel). 2010 Jul 14;2(3):1492-512.
Title: The Kinase Mirk/dyrk1B: A Possible Therapeutic Target in Pancreatic Cancer.
Author: Friedman, Eileen
PMID: 24281169
Journal: Middle East J Cancer. 2010 Jan;1(1):27-36.
Title: Differences in Molecular Pathologic Characteristics of Pancreatic Adenocarcinoma between Egyptian and Moroccan Patients.
Author: Robinson, Sara|Soliman, Amr|Karkouri, Mehdi|Omer, Hoda Gad|Greenson, Joel F
PMID: 25598952
Journal: Int J Cancer. 2011 Jun 15;128(12):2783-92.
Title: Alteration of strain background and a high omega-6 fat diet induces earlier onset of pancreatic neoplasia in EL-Kras transgenic mice.
Author: Cheon, Eric C|Strouch, Matthew J|Barron, Morgan R|Ding, Yongzeng|Melstrom, Laleh G|Krantz, Seth B|Mullapudi, Bhargava|Adrian, Kevin|Rao, Sambasiva|Adrian, Thomas E|Bentrem, David J|Grippo, Paul J
PMID: 20725998
Journal: Cancer Chemother Pharmacol. 2011 Feb;67(2):481-7.
Title: The role of K-ras gene mutation in TRAIL-induced apoptosis in pancreatic and lung cancer cell lines.
Author: Sahu, Ravi P|Batra, Sanjay|Kandala, Prabodh K|Brown, Thomas L|Srivastava, Sanjay K
PMID: 20848283
Journal: Gastroenterology. 2011 Apr;140(4):1303-1313.e1-3.
Title: Inactivation of Brca2 promotes Trp53-associated but inhibits KrasG12D-dependent pancreatic cancer development in mice.
Author: Rowley, Matthew|Ohashi, Akihiro|Mondal, Gourish|Mills, Lisa|Yang, Lin|Zhang, Lizhi|Sundsbak, Rhianna|Shapiro, Virginia|Muders, Michael H|Smyrk, Thomas|Couch, Fergus J
PMID: 21199651
Journal: Int J Cancer. 2011 Nov 15;129(10):2349-59.
Title: Glutamate increases pancreatic cancer cell invasion and migration via AMPA receptor activation and Kras-MAPK signaling.
Author: Herner, Alexander|Sauliunaite, Danguole|Michalski, Christoph W|Erkan, Mert|De Oliveira, Tiago|Abiatari, Ivane|Kong, Bo|Esposito, Irene|Friess, Helmut|Kleeff, Jorg
PMID: 21207374
Journal: Oncogene. 2011 May 5;30(18):2123-34.
Title: Oncogenic Ras/Src cooperativity in pancreatic neoplasia.
Author: Shields, D J|Murphy, E A|Desgrosellier, J S|Mielgo, A|Lau, S K M|Barnes, L A|Lesperance, J|Huang, M|Schmedt, C|Tarin, D|Lowy, A M|Cheresh, D A
PMID: 21242978
Journal: Cancer Res. 2011 Mar 15;71(6):2328-38.
Title: DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism.
Author: Sureban, Sripathi M|May, Randal|Lightfoot, Stan A|Hoskins, Aimee B|Lerner, Megan|Brackett, Daniel J|Postier, Russell G|Ramanujam, Rama|Mohammed, Altaf|Rao, Chinthalapally V|Wyche, James H|Anant, Shrikant|Houchen, Courtney W
PMID: 21285251
Journal: Mol Cancer Ther. 2011 Apr;10(4):670-8.
Title: Context dependence of checkpoint kinase 1 as a therapeutic target for pancreatic cancers deficient in the BRCA2 tumor suppressor.
Author: Hattori, Hiroyoshi|Skoulidis, Ferdinandos|Russell, Paul|Venkitaraman, Ashok R
PMID: 21289082
Journal: Eur J Epidemiol. 2011 Mar;26(3):229-36.
Title: Clinical validity of detecting K-ras mutations for the diagnosis of exocrine pancreatic cancer: a prospective study in a clinically-relevant spectrum of patients.
Author: Parker, Lucy A|Porta, Miquel|Lumbreras, Blanca|Lopez, Tomas|Guarner, Luisa|Hernandez-Aguado, Ildefonso|Carrato, Alfredo|Corominas, Josep M|Rifa, Juli|Fernandez, Esteve|Alguacil, Joan|Malats, Nuria|Real, Francisco X
PMID: 21298467
Journal: PLoS One. 2011 Jan 31;6(1):e16530.
Title: Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition.
Author: Shankar, Sharmila|Nall, Dara|Tang, Su-Ni|Meeker, Daniel|Passarini, Jenna|Sharma, Jay|Srivastava, Rakesh K
PMID: 21304978
Journal: PLoS One. 2011 Feb 2;6(2):e16786.
Title: Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse model.
Author: Ray, Kevin C|Bell, Kayla M|Yan, Jingbo|Gu, Guoqiang|Chung, Christine H|Washington, M Kay|Means, Anna L
PMID: 21311774
Journal: Br J Cancer. 2011 Mar 15;104(6):1038-48.
Title: Activated KrasG(1)(2)D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin.
Author: Rachagani, S|Senapati, S|Chakraborty, S|Ponnusamy, M P|Kumar, S|Smith, L M|Jain, M|Batra, S K
PMID: 21364589
Journal: Clin Cancer Res. 2011 May 1;17(9):2744-56.
Title: Synergistic effect between erlotinib and MEK inhibitors in KRAS wild-type human pancreatic cancer cells.
Author: Diep, Caroline H|Munoz, Ruben M|Choudhary, Ashish|Von Hoff, Daniel D|Han, Haiyong
PMID: 21385921
Journal: Cancer Cell. 2011 Apr 12;19(4):456-69.
Title: Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.
Author: Lesina, Marina|Kurkowski, Magdalena U|Ludes, Katharina|Rose-John, Stefan|Treiber, Matthias|Kloppel, Gunter|Yoshimura, Akihiko|Reindl, Wolfgang|Sipos, Bence|Akira, Shizuo|Schmid, Roland M|Algul, Hana
PMID: 21481788
Journal: Anticancer Agents Med Chem. 2011 Jun;11(5):455-63.
Title: Targeting phosphoinositide 3-kinase pathways in pancreatic cancer--from molecular signalling to clinical trials.
Author: Falasca, Marco|Selvaggi, Federico|Buus, Richard|Sulpizio, Sara|Edling, Charlotte E
PMID: 21521159
Journal: Mod Pathol. 2011 Sep;24(9):1229-36.
Title: Analysis of LKB1 mutations and other molecular alterations in pancreatic acinar cell carcinoma.
Author: de Wilde, Roeland F|Ottenhof, Niki A|Jansen, Marnix|Morsink, Folkert H M|de Leng, Wendy W J|Offerhaus, G Johan A|Brosens, Lodewijk A A
PMID: 21572398
Journal: PLoS One. 2011 May 12;6(5):e19721.
Title: Plasma proteome profiles associated with inflammation, angiogenesis, and cancer.
Author: Kelly-Spratt, Karen S|Pitteri, Sharon J|Gurley, Kay E|Liggitt, Denny|Chin, Alice|Kennedy, Jacob|Wong, Chee-Hong|Zhang, Qing|Buson, Tina Busald|Wang, Hong|Hanash, Samir M|Kemp, Christopher J
PMID: 21589862
Journal: World J Clin Oncol. 2011 Mar 10;2(3):158-63.
Title: Recent progress and limitations of chemotherapy for pancreatic and biliary tract cancers.
Author: Tada, Minoru|Nakai, Yousuke|Sasaki, Takashi|Hamada, Tsuyoshi|Nagano, Rie|Mohri, Dai|Miyabayashi, Koji|Yamamoto, Keisuke|Kogure, Hirofumi|Kawakubo, Kazumichi|Ito, Yukiko|Yamamoto, Natsuyo|Sasahira, Naoki|Hirano, Kenji|Ijichi, Hideaki|Tateishi, Keishuke|Isa
PMID: 21611090
Journal: World J Clin Oncol. 2011 May 10;2(5):195-202.
Title: Genetically-engineered mouse models for pancreatic cancer: Advances and current limitations.
Author: Ijichi, Hideaki
PMID: 21611096
Journal: Mol Cancer Ther. 2011 Aug;10(8):1470-80.
Title: Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice.
Author: Pramanik, Dipankar|Campbell, Nathaniel R|Karikari, Collins|Chivukula, Raghu|Kent, Oliver A|Mendell, Joshua T|Maitra, Anirban
PMID: 21622730
Journal: Cancer Radiother. 2011 Aug;15(5):365-75.
Title: [New perspectives for radiosensitization in pancreatic carcinoma: a review of mechanisms involved in pancreatic tumorigenesis].
Author: Huguet, F|Fernet, M|Monnier, L|Touboul, E|Favaudon, V
PMID: 21664851
Journal: Gastroenterology. 2011 Aug;141(2):719-30, 730.e1-7.
Title: Early requirement of Rac1 in a mouse model of pancreatic cancer.
Author: Heid, Irina|Lubeseder-Martellato, Clara|Sipos, Bence|Mazur, Pawel K|Lesina, Marina|Schmid, Roland M|Siveke, Jens T
PMID: 21684285
Journal: PLoS One. 2011;6(6):e20919.
Title: Cten is targeted by Kras signalling to regulate cell motility in the colon and pancreas.
Author: Al-Ghamdi, Saleh|Albasri, Abdulkader|Cachat, Julien|Ibrahem, Salih|Muhammad, Belal A|Jackson, Darryl|Nateri, Abdolrahman S|Kindle, Karin B|Ilyas, Mohammad
PMID: 21698197
Journal: Gastroenterology. 2011 Sep;141(3):1091-101.
Title: Deletion of Rb accelerates pancreatic carcinogenesis by oncogenic Kras and impairs senescence in premalignant lesions.
Author: Carriere, Catherine|Gore, A Jesse|Norris, Alixanna M|Gunn, Jason R|Young, Alison L|Longnecker, Daniel S|Korc, Murray
PMID: 21699781
Journal: Adv Cancer Res. 2011;110:1-17.
Title: Hedgehog signaling and pancreatic tumor development.
Author: Lauth, Matthias|Toftgard, Rune
PMID: 21704226
Journal: Nature. 2011 Jul 6;475(7354):106-9.
Title: Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.
Author: DeNicola, Gina M|Karreth, Florian A|Humpton, Timothy J|Gopinathan, Aarthi|Wei, Cong|Frese, Kristopher|Mangal, Dipti|Yu, Kenneth H|Yeo, Charles J|Calhoun, Eric S|Scrimieri, Francesca|Winter, Jordan M|Hruban, Ralph H|Iacobuzio-Donahue, Christine|Kern, Scott
PMID: 21734707
Journal: PLoS One. 2011;6(6):e20687.
Title: Tissue and serum microRNAs in the Kras(G12D) transgenic animal model and in patients with pancreatic cancer.
Author: LaConti, Joseph J|Shivapurkar, Narayan|Preet, Anju|Deslattes Mays, Anne|Peran, Ivana|Kim, Sung Eun|Marshall, John L|Riegel, Anna T|Wellstein, Anton
PMID: 21738581
Journal: Nat Rev Gastroenterol Hepatol. 2011 Jul 12;8(8):467-72.
Title: From tissue turnover to the cell of origin for pancreatic cancer.
Author: Kong, Bo|Michalski, Christoph W|Erkan, Mert|Friess, Helmut|Kleeff, Jorg
PMID: 21750515
Journal: Pancreas. 2011 Aug;40(6):905-10.
Title: Establishment and characterization of a new cell line, A99, from a primary small cell carcinoma of the pancreas.
Author: Yachida, Shinichi|Zhong, Yi|Patrascu, Raul|Davis, Meghan B|Morsberger, Laura A|Griffin, Constance A|Hruban, Ralph H|Laheru, Daniel|Iacobuzio-Donahue, Christine A
PMID: 21768923
Journal: Genes Cancer. 2011 Feb;2(2):108-19.
Title: MicroRNA-375 and MicroRNA-221: Potential Noncoding RNAs Associated with Antiproliferative Activity of Benzyl Isothiocyanate in Pancreatic Cancer.
Author: Basu, Aruna|Alder, Hansjuerg|Khiyami, Amer|Leahy, Patrick|Croce, Carlo M|Haldar, Subrata
PMID: 21779484
Journal: Expert Opin Ther Targets. 2011 Oct;15(10):1183-96.
Title: Emerging pathways and future targets for the molecular therapy of pancreatic cancer.
Author: Vaccaro, Vanja|Melisi, Davide|Bria, Emilio|Cuppone, Federica|Ciuffreda, Ludovica|Pino, Maria Simona|Gelibter, Alain|Tortora, Giampaolo|Cognetti, Francesco|Milella, Michele
PMID: 21819318
Journal: Mol Cancer Res. 2011 Oct;9(10):1294-304.
Title: MT1-MMP cooperates with Kras(G12D) to promote pancreatic fibrosis through increased TGF-beta signaling.
Author: Krantz, Seth B|Shields, Mario A|Dangi-Garimella, Surabhi|Cheon, Eric C|Barron, Morgan R|Hwang, Rosa F|Rao, M Sambasiva|Grippo, Paul J|Bentrem, David J|Munshi, Hidayatullah G
PMID: 21856775
Journal: Mol Cancer Ther. 2011 Oct;10(10):1993-9.
Title: Impact of KRAS mutations on clinical outcomes in pancreatic cancer patients treated with first-line gemcitabine-based chemotherapy.
Author: Kim, Seung Tae|Lim, Do Hyoung|Jang, Kee-Taek|Lim, Taekyu|Lee, Jeeyun|Choi, Yoon-La|Jang, Hye-Lim|Yi, Jun Ho|Baek, Kyung Kee|Park, Se Hoon|Park, Young Suk|Lim, Ho Yeong|Kang, Won Ki|Park, Joon Oh
PMID: 21862683
Journal: Am J Gastroenterol. 2011 Dec;106(12):2104-11.
Title: Detection of KRAS gene mutations in endoscopic ultrasound-guided fine-needle aspiration biopsy for improving pancreatic cancer diagnosis.
Author: Wang, Xiaowei|Gao, Jun|Ren, Yan|Gu, Junjun|Du, Yiqi|Chen, Jie|Jin, Zhendong|Zhan, Xianbao|Li, ZhaoShen|Huang, Haojie|Lv, ShunLi|Gong, Yanfang
PMID: 21876563
Journal: Oncology. 2011;81(1):3-8.
Title: KRAS mutation in metastatic pancreatic ductal adenocarcinoma: results of a multicenter phase II study evaluating efficacy of cetuximab plus gemcitabine/oxaliplatin (GEMOXCET) in first-line therapy.
Author: Kullmann, F|Hartmann, A|Stohr, R|Messmann, H|Dollinger, M M|Trojan, J|Fuchs, M|Hollerbach, S|Harder, J|Troppmann, M|Kutscheidt, A|Endlicher, E
PMID: 21894049
Journal: Am J Surg Pathol. 2011 Dec;35(12):1812-7.
Title: Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas.
Author: Yamaguchi, Hiroshi|Kuboki, Yuko|Hatori, Takashi|Yamamoto, Masakazu|Shiratori, Keiko|Kawamura, Shunji|Kobayashi, Makio|Shimizu, Michio|Ban, Shinichi|Koyama, Isamu|Higashi, Morihiro|Shin, Nobuhiro|Ishida, Kazuyuki|Morikawa, Takanori|Motoi, Fuyuhiko|Unno, Mi
PMID: 21945955
Journal: Methods Cell Biol. 2011;105:367-81.
Title: Screening pancreatic oncogenes in zebrafish using the Gal4/UAS system.
Author: Liu, Shu|Leach, Steven D
PMID: 21951538
Journal: Pancreatology. 2011;11(5):482-6.
Title: EUS-FNA mutational analysis in differentiating autoimmune pancreatitis and pancreatic cancer.
Author: Khalid, Asif|Dewitt, John|Ohori, N Paul|Chen, Jey-Hsin|Fasanella, Kenneth E|Sanders, Michael|McGrath, Kevin M|Nikiforova, Marina
PMID: 21997479
Journal: Mol Cancer Ther. 2011 Dec;10(12):2426-36.
Title: GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway.
Author: Wallin, Jeffrey J|Edgar, Kyle A|Guan, Jane|Berry, Megan|Prior, Wei Wei|Lee, Leslie|Lesnick, John D|Lewis, Cristina|Nonomiya, Jim|Pang, Jodie|Salphati, Laurent|Olivero, Alan G|Sutherlin, Daniel P|O'Brien, Carol|Spoerke, Jill M|Patel, Sonal|Lensun, Letitia|
PMID: 21998291
Journal: J Clin Invest. 2011 Dec;121(12):4685-99.
Title: Crosstalk between the canonical NF-kappaB and Notch signaling pathways inhibits Ppargamma expression and promotes pancreatic cancer progression in mice.
Author: Maniati, Eleni|Bossard, Maud|Cook, Natalie|Candido, Juliana B|Emami-Shahri, Nia|Nedospasov, Sergei A|Balkwill, Frances R|Tuveson, David A|Hagemann, Thorsten
PMID: 22056382
Journal: Chin Med J (Engl). 2011 Jul 5;124(13):2065-7.
Title: Novel mutations of PRSS1 gene in patients with pancreatic cancer among Han population.
Author: Zeng, Kai|Liu, Qi-cai|Lin, Jian-hua|Lin, Xin-hua|Zhuang, Ze-hao|Gao, Feng|Ou, Qi-shui
PMID: 22088471
Journal: Oncotarget. 2011 Nov;2(11):862-73.
Title: Disruption of p16 and activation of Kras in pancreas increase ductal adenocarcinoma formation and metastasis in vivo.
Author: Qiu, Wanglong|Sahin, Fikret|Iacobuzio-Donahue, Christine A|Garcia-Carracedo, Dario|Wang, Wendy M|Kuo, Chia-Yu|Chen, Doris|Arking, Dan E|Lowy, Andrew M|Hruban, Ralph H|Remotti, Helen E|Su, Gloria H
PMID: 22113502
Journal: PLoS One. 2011;6(11):e27725.
Title: Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic Kras in the nestin cell lineage.
Author: Carriere, Catherine|Young, Alison L|Gunn, Jason R|Longnecker, Daniel S|Korc, Murray
PMID: 22140463
Journal: Small GTPases. 2011 Sep;2(5):264-267.
Title: Ras, PI3K/Akt and senescence: Paradoxes provide clues for pancreatic cancer therapy.
Author: Kennedy, Alyssa L|Adams, Peter D|Morton, Jennifer P
PMID: 22292129
Journal: Zhonghua Bing Li Xue Za Zhi. 2011 Nov;40(11):754-7.
Title: [Colloid carcinoma of pancreas: a clinicopathologic study of 4 cases].
Author: Chang, Xiao-yan|Jiang, Ying|Li, Ji|Luo, Yu-feng|Cao, Jin-ling|Chen, Jie
PMID: 22336159
Journal: Mol Biol (Mosk). 2011 Sep-Oct;45(5):863-70.
Title: [Detection of KRAS mutations in tumor cells using biochips].
Author: Emel'ianova, M A|Amosenko, F A|Chudinov, A V|Surzhikov, S A|Kazubskaia, T P|Liubchenko, L N|Nasedkina, T V
PMID: 22393783
Journal: Cancer Discov. 2011 Jul;1(2):103-5.
Title: Kras, Pten, NF-kappaB, and inflammation: dangerous liaisons.
Author: Chiao, Paul J|Ling, Jianhua
PMID: 22586351
Journal: Exp Ther Med. 2011 Sep;2(5):969-975.
Title: Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in BXPC-3 and PANC-1 human pancreatic cancer cells.
Author: Wang, Lin|Zhu, Zhi-Xia|Zhang, Wen-Ying|Zhang, Wei-Min
PMID: 22977607
Journal: Cancers (Basel). 2011 Feb 24;3(1):872-82.
Title: Molecular endoscopic ultrasound for diagnosis of pancreatic cancer.
Author: Bournet, Barbara|Pointreau, Adeline|Delpu, Yannick|Selves, Janick|Torrisani, Jerome|Buscail, Louis|Cordelier, Pierre
PMID: 24212643
Journal: Cancers (Basel). 2011 Feb 25;3(1):897-912.
Title: Tissue Transglutaminase (TG2)-Induced Inflammation in Initiation, Progression, and Pathogenesis of Pancreatic Cancer.
Author: Mehta, Kapil|Han, Amy
PMID: 24212645
Journal: J Surg Res. 2012 Jan;172(1):29-39.
Title: Five primary human pancreatic adenocarcinoma cell lines established by the outgrowth method.
Author: Ruckert, Felix|Aust, Daniela|Bohme, Iris|Werner, Kristin|Brandt, Aljoscha|Diamandis, Eleftherios P|Krautz, Christian|Hering, Sandra|Saeger, Hans-Detlev|Grutzmann, Robert|Pilarsky, Christian
PMID: 21683373
Journal: Oncogene. 2012 May 17;31(20):2535-44.
Title: A KrasG12D-driven genetic mouse model of pancreatic cancer requires glypican-1 for efficient proliferation and angiogenesis.
Author: Whipple, C A|Young, A L|Korc, M
PMID: 21996748
Journal: J Gastroenterol. 2012 Feb;47(2):203-13.
Title: Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression.
Author: Mohri, Dai|Asaoka, Yoshinari|Ijichi, Hideaki|Miyabayashi, Koji|Kudo, Yotaro|Seto, Motoko|Ohta, Miki|Tada, Motohisa|Tanaka, Yasuo|Ikenoue, Tsuneo|Tateishi, Keisuke|Isayama, Hiroyuki|Kanai, Fumihiko|Fukushima, Noriyoshi|Tada, Minoru|Kawabe, Takao|Omata, Mas
PMID: 22041919
Journal: J Gastrointest Surg. 2012 Jan;16(1):104-12; discussion 112.
Title: RAGE gene deletion inhibits the development and progression of ductal neoplasia and prolongs survival in a murine model of pancreatic cancer.
Author: DiNorcia, Joseph|Lee, Minna K|Moroziewicz, Dorota N|Winner, Megan|Suman, Paritosh|Bao, Fei|Remotti, Helen E|Zou, Yu Shan|Yan, Shi Fang|Qiu, Wanglong|Su, Gloria H|Schmidt, Ann Marie|Allendorf, John D
PMID: 22052106
Journal: Mod Pathol. 2012 Mar;25(3):439-48.
Title: Large duct type invasive adenocarcinoma of the pancreas with microcystic and papillary patterns: a potential microscopic mimic of non-invasive ductal neoplasia.
Author: Bagci, Pelin|Andea, Aleodor A|Basturk, Olca|Jang, Kee-Taek|Erbarut, Ipek|Adsay, Volkan
PMID: 22056954
Journal: Cancer. 2012 May 15;118(10):2623-31.
Title: Stool DNA testing for the detection of pancreatic cancer: assessment of methylation marker candidates.
Author: Kisiel, John B|Yab, Tracy C|Taylor, William R|Chari, Suresh T|Petersen, Gloria M|Mahoney, Douglas W|Ahlquist, David A
PMID: 22083596
Journal: Cancer Res. 2012 Jan 1;72(1):88-99.
Title: GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells.
Author: Joost, Simon|Almada, Luciana L|Rohnalter, Verena|Holz, Philipp S|Vrabel, Anne M|Fernandez-Barrena, Maite G|McWilliams, Robert R|Krause, Michael|Fernandez-Zapico, Martin E|Lauth, Matthias
PMID: 22086851
Journal: J Surg Res. 2012 Mar;173(1):105-12.
Title: Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression.
Author: Krantz, Seth B|Shields, Mario A|Dangi-Garimella, Surabhi|Munshi, Hidayatullah G|Bentrem, David J
PMID: 22099597
Journal: Clin Cancer Res. 2012 Jan 15;18(2):524-33.
Title: Loss of 18q22.3 involving the carboxypeptidase of glutamate-like gene is associated with poor prognosis in resected pancreatic cancer.
Author: Lee, Jih-Hsiang|Giovannetti, Elisa|Hwang, Jin-Hyeok|Petrini, Iacopo|Wang, Qiuyan|Voortman, Johannes|Wang, Yonghong|Steinberg, Seth M|Funel, Niccola|Meltzer, Paul S|Wang, Yisong|Giaccone, Giuseppe
PMID: 22128300
Journal: Gut. 2012 Jun;61(6):877-84.
Title: Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice.
Author: Gopinathan, Aarthi|Denicola, Gina M|Frese, Kristopher K|Cook, Natalie|Karreth, Florian A|Mayerle, Julia|Lerch, Markus M|Reinheckel, Thomas|Tuveson, David A
PMID: 22157328
Journal: Oncogene. 2012 Oct 11;31(41):4484-9.
Title: N-cadherin haploinsufficiency increases survival in a mouse model of pancreatic cancer.
Author: Su, Y|Li, J|Witkiewicz, A K|Brennan, D|Neill, T|Talarico, J|Radice, G L
PMID: 22158044
Journal: Ann Surg. 2012 Feb;255(2):326-33.
Title: Clinicopathological characteristics and molecular analyses of multifocal intraductal papillary mucinous neoplasms of the pancreas.
Author: Matthaei, Hanno|Norris, Alexis L|Tsiatis, Athanasios C|Olino, Kelly|Hong, Seung-Mo|dal Molin, Marco|Goggins, Michael G|Canto, Marcia|Horton, Karen M|Jackson, Keith D|Capelli, Paola|Zamboni, Giuseppe|Bortesi, Laura|Furukawa, Toru|Egawa, Shinichi|Ishida, Ma
PMID: 22167000
Journal: Int J Cancer. 2012 Oct 1;131(7):1720-31.
Title: Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model.
Author: Siddique, Hifzur Rahman|Liao, D Joshua|Mishra, Shrawan Kumar|Schuster, Todd|Wang, Lei|Matter, Brock|Campbell, Paul M|Villalta, Peter|Nanda, Sanjeev|Deng, Yibin|Saleem, Mohammad
PMID: 22190076
Journal: Curr Mol Med. 2012 Mar;12(3):331-41.
Title: Genomic sequencing of key genes in mouse pancreatic cancer cells.
Author: Wang, Y|Zhang, Y|Yang, J|Ni, X|Liu, S|Li, Z|Hodges, S E|Fisher, W E|Brunicardi, F C|Gibbs, R A|Gingras, M-C|Li, M
PMID: 22208613
Journal: Mod Pathol. 2012 May;25(5):758-66.
Title: Overexpression and oncogenic function of aldo-keto reductase family 1B10 (AKR1B10) in pancreatic carcinoma.
Author: Chung, Yeon Tae|Matkowskyj, Kristina A|Li, Haonan|Bai, Han|Zhang, Wanying|Tsao, Ming-Sound|Liao, Jie|Yang, Guang-Yu
PMID: 22222635
Journal: J Clin Invest. 2012 Feb;122(2):639-53.
Title: Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice.
Author: Collins, Meredith A|Bednar, Filip|Zhang, Yaqing|Brisset, Jean-Christophe|Galban, Stefanie|Galban, Craig J|Rakshit, Sabita|Flannagan, Karen S|Adsay, N Volkan|Pasca di Magliano, Marina
PMID: 22232209
Journal: Gut. 2012 Oct;61(10):1454-64.
Title: Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice.
Author: Grippo, Paul J|Fitchev, Philip S|Bentrem, David J|Melstrom, Laleh G|Dangi-Garimella, Surabhi|Krantz, Seth B|Heiferman, Michael J|Chung, Chuhan|Adrian, Kevin|Cornwell, Mona L|Flesche, Jan B|Rao, Sambasiva M|Talamonti, Mark S|Munshi, Hidayatullah G|Crawford
PMID: 22234980
Journal: Int J Cancer. 2012 Oct 15;131(8):1951-62.
Title: Atorvastatin delays progression of pancreatic lesions to carcinoma by regulating PI3/AKT signaling in p48Cre/+ LSL-KrasG12D/+ mice.
Author: Mohammed, Altaf|Qian, Li|Janakiram, Naveena B|Lightfoot, Stan|Steele, Vernon E|Rao, Chinthalapally V
PMID: 22287227
Journal: Cancer Biol Ther. 2012 Mar;13(5):314-20.
Title: Modified PNA-PCR method: a convenient and accurate method to screen plasma KRAS mutations of cancer patients.
Author: Yu, Shaorong|Wu, Jianzhong|Xu, Shu|Tan, Guolei|Liu, Baorui|Feng, Jifeng
PMID: 22310974
Journal: J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:23-6.
Title: Bone marrow-derived proangiogenic cells in pancreatic cancer.
Author: Mizukami, Yusuke
PMID: 22320912
Journal: PLoS One. 2012;7(2):e32068.
Title: MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors.
Author: Jiao, Long R|Frampton, Adam E|Jacob, Jimmy|Pellegrino, Loredana|Krell, Jonathan|Giamas, Georgios|Tsim, Nicole|Vlavianos, Panagiotis|Cohen, Patrizia|Ahmad, Raida|Keller, Andreas|Habib, Nagy A|Stebbing, Justin|Castellano, Leandro
PMID: 22384141
Journal: Mol Cancer Ther. 2012 May;11(5):1193-202.
Title: Cotargeting MAPK and PI3K signaling with concurrent radiotherapy as a strategy for the treatment of pancreatic cancer.
Author: Williams, Terence M|Flecha, Athena R|Keller, Paul|Ram, Ashwin|Karnak, David|Galban, Stefanie|Galban, Craig J|Ross, Brian D|Lawrence, Theodore S|Rehemtulla, Alnawaz|Sebolt-Leopold, Judith
PMID: 22411900
Journal: Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):5934-41.
Title: Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma.
Author: Mann, Karen M|Ward, Jerrold M|Yew, Christopher Chin Kuan|Kovochich, Anne|Dawson, David W|Black, Michael A|Brett, Benjamin T|Sheetz, Todd E|Dupuy, Adam J|Chang, David K|Biankin, Andrew V|Waddell, Nicola|Kassahn, Karin S|Grimmond, Sean M|Rust, Alistair G|Ad
PMID: 22421440
Journal: Pancreas. 2012 Apr;41(3):428-34.
Title: EGFR and KRAS mutational analysis and their correlation to survival in pancreatic and periampullary cancer.
Author: Oliveira-Cunha, Melissa|Hadfield, Kristen D|Siriwardena, Ajith K|Newman, William
PMID: 22422135
Journal: Curr Drug Targets. 2012 Jun;13(6):744-52.
Title: Molecular pathology of pancreatic cancer: from bench-to-bedside translation.
Author: Corbo, Vincenzo|Tortora, Giampaolo|Scarpa, Aldo
PMID: 22458520
Journal: Am J Pathol. 2012 Jun;180(6):2214-21.
Title: Tif1gamma suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway.
Author: Vincent, David F|Gout, Johann|Chuvin, Nicolas|Arfi, Vanessa|Pommier, Roxane M|Bertolino, Philippe|Jonckheere, Nicolas|Ripoche, Doriane|Kaniewski, Bastien|Martel, Sylvie|Langlois, Jean-Baptiste|Goddard-Leon, Sophie|Colombe, Amelie|Janier, Marc|Van Seuninge
PMID: 22469842
Journal: J Transl Med. 2012 Apr 2;10:68.
Title: Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells.
Author: Heinrich, Eileen L|Lee, Wendy|Lu, Jianming|Lowy, Andrew M|Kim, Joseph
PMID: 22472349
Journal: Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):E1038-47.
Title: The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis.
Author: Rajurkar, Mihir|De Jesus-Monge, Wilfredo E|Driscoll, David R|Appleman, Victoria A|Huang, He|Cotton, Jennifer L|Klimstra, David S|Zhu, Lihua J|Simin, Karl|Xu, Lan|McMahon, Andrew P|Lewis, Brian C|Mao, Junhao
PMID: 22493246
Journal: Anticancer Res. 2012 Apr;32(4):1457-61.
Title: Comparison of the chemosensitivity of the primary lesion and a pancreatic metastasis of colon cancer: a case report.
Author: Tamagawa, Hiroshi|Miyagi, Yohei|Numata, Masakatsu|Yamamoto, Naoto|Shiozawa, Manabu|Morinaga, Soichiro|Sekiyama, Akiko|Sekiguchi, Hironobu|Sakuma, Yuji|Kameda, Yoichi|Akaike, Makoto|Masuda, Munetaka|Imada, Toshio
PMID: 22493386
Journal: World J Gastroenterol. 2012 Mar 28;18(12):1286-94.
Title: Mouse models of pancreatic cancer.
Author: Herreros-Villanueva, Marta|Hijona, Elizabeth|Cosme, Angel|Bujanda, Luis
PMID: 22493542
Journal: Proc Natl Acad Sci U S A. 2012 May 1;109(18):7031-6.
Title: The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia.
Author: Kang, Rui|Loux, Tara|Tang, Daolin|Schapiro, Nicole E|Vernon, Philip|Livesey, Kristen M|Krasinskas, Alyssa|Lotze, Michael T|Zeh, Herbert J 3rd
PMID: 22509024
Journal: Cancer. 2012 Nov 1;118(21):5217-26.
Title: Treatment of pancreatic cancer using an oncolytic virus harboring the lipocalin-2 gene.
Author: Xu, Bin|Zheng, Wen-Yan|Jin, Da-Yong|Wang, Dan-Song|Liu, Xin-Yuan|Qin, Xin-Yu
PMID: 22517373
Journal: Cell. 2012 Apr 27;149(3):656-70.
Title: Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
Author: Ying, Haoqiang|Kimmelman, Alec C|Lyssiotis, Costas A|Hua, Sujun|Chu, Gerald C|Fletcher-Sananikone, Eliot|Locasale, Jason W|Son, Jaekyoung|Zhang, Hailei|Coloff, Jonathan L|Yan, Haiyan|Wang, Wei|Chen, Shujuan|Viale, Andrea|Zheng, Hongwu|Paik, Ji-hye|Lim, Ca
PMID: 22541435
Journal: Invest New Drugs. 2012 Dec;30(6):2391-9.
Title: Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer.
Author: Laheru, Daniel|Shah, Preeti|Rajeshkumar, N V|McAllister, Florencia|Taylor, Gretchen|Goldsweig, Howard|Le, Dung T|Donehower, Ross|Jimeno, Antonio|Linden, Sheila|Zhao, Ming|Song, Dongweon|Rudek, Michelle A|Hidalgo, Manuel
PMID: 22547163
Journal: J Clin Invest. 2012 Jun;122(6):2092-103.
Title: Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.
Author: Hamidi, Tewfik|Algul, Hana|Cano, Carla Eliana|Sandi, Maria Jose|Molejon, Maria Ines|Riemann, Marc|Calvo, Ezequiel Luis|Lomberk, Gwen|Dagorn, Jean-Charles|Weih, Falk|Urrutia, Raul|Schmid, Roland Michael|Iovanna, Juan Lucio
PMID: 22565310
Journal: Nat Rev Clin Oncol. 2012 May 15;9(7):368.
Title: Pancreatic cancer: Mouse models link metabolism and deubiquitination with Kras.
Author: Kirk, Rebecca
PMID: 22584999
Journal: Cancer Res. 2012 May 15;72(10):2554-64.
Title: KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer.
Author: Kelber, Jonathan A|Reno, Theresa|Kaushal, Sharmeela|Metildi, Cristina|Wright, Tracy|Stoletov, Konstantin|Weems, Jessica M|Park, Frederick D|Mose, Evangeline|Wang, Yingchun|Hoffman, Robert M|Lowy, Andrew M|Bouvet, Michael|Klemke, Richard L
PMID: 22589274
Journal: J Proteome Res. 2012 Jul 6;11(7):3908-13.
Title: GeLC-MRM quantitation of mutant KRAS oncoprotein in complex biological samples.
Author: Halvey, Patrick J|Ferrone, Cristina R|Liebler, Daniel C
PMID: 22671702
Journal: Cancer Cell. 2012 Jun 12;21(6):715-6.
Title: Silencing the killers: paracrine immune suppression in pancreatic cancer.
Author: Cox, Adrienne D|Olive, Kenneth P
PMID: 22698396
Journal: Cancer Cell. 2012 Jun 12;21(6):836-47.
Title: Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia.
Author: Pylayeva-Gupta, Yuliya|Lee, Kyoung Eun|Hajdu, Cristina H|Miller, George|Bar-Sagi, Dafna
PMID: 22698407
Journal: Nature. 2012 Apr 29;486(7402):266-70.
Title: The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma.
Author: Perez-Mancera, Pedro A|Rust, Alistair G|van der Weyden, Louise|Kristiansen, Glen|Li, Allen|Sarver, Aaron L|Silverstein, Kevin A T|Grutzmann, Robert|Aust, Daniela|Rummele, Petra|Knosel, Thomas|Herd, Colin|Stemple, Derek L|Kettleborough, Ross|Brosnan, Jacqu
PMID: 22699621
Journal: Autophagy. 2012 Jun;8(6):989-91.
Title: AGER/RAGE-mediated autophagy promotes pancreatic tumorigenesis and bioenergetics through the IL6-pSTAT3 pathway.
Author: Kang, Rui|Tang, Daolin|Lotze, Michael T|Zeh, Herbert J 3rd
PMID: 22722139
Journal: Clin Cancer Res. 2012 Aug 15;18(16):4303-12.
Title: Genome-wide somatic copy number alterations in low-grade PanINs and IPMNs from individuals with a family history of pancreatic cancer.
Author: Hong, Seung-Mo|Vincent, Audrey|Kanda, Mitsuro|Leclerc, Julie|Omura, Noriyuki|Borges, Michael|Klein, Alison P|Canto, Marcia Irene|Hruban, Ralph H|Goggins, Michael
PMID: 22723370
Journal: J Membr Biol. 2012 Jun;245(5-6):255-62.
Title: Changes in connexin43 expression and localization during pancreatic cancer progression.
Author: Solan, Joell L|Hingorani, Sunil R|Lampe, Paul D
PMID: 22729649
Journal: Cancer Res. 2012 Sep 1;72(17):4472-82.
Title: Targeting eNOS in pancreatic cancer.
Author: Lampson, Benjamin L|Kendall, S Disean|Ancrile, Brooke B|Morrison, Meghan M|Shealy, Michael J|Barrientos, Katharine S|Crowe, Matthew S|Kashatus, David F|White, Rebekah R|Gurley, Susan B|Cardona, Diana M|Counter, Christopher M
PMID: 22738914
Journal: Clin Chem. 2012 Sep;58(9):1332-41.
Title: Nanofluidic digital PCR for KRAS mutation detection and quantification in gastrointestinal cancer.
Author: Azuara, Daniel|Ginesta, Mireia M|Gausachs, Mireia|Rodriguez-Moranta, Francisco|Fabregat, Joan|Busquets, Juli|Pelaez, Nuria|Boadas, Jaume|Galter, Sara|Moreno, Victor|Costa, Jose|de Oca, Javier|Capella, Gabriel
PMID: 22745110
Journal: Pancreas. 2012 Nov;41(8):1195-205.
Title: Genetic markers of malignant transformation in intraductal papillary mucinous neoplasm of the pancreas: a meta-analysis.
Author: Nissim, Sahar|Idos, Gregory E|Wu, Bechien
PMID: 22750975
Journal: Curr Opin Gastroenterol. 2012 Sep;28(5):516-22.
Title: Emerging frontiers in pancreatic cancer research: elaboration of key genes, cells and the extracellular milieu.
Author: Kumar-Sinha, Chandan|Wei, Iris|Simeone, Diane M
PMID: 22759592
Journal: Genome Med. 2012 Jul 4;4(7):56.
Title: Cancer of the ampulla of Vater: analysis of the whole genome sequence exposes a potential therapeutic vulnerability.
Author: Demeure, Michael J|Craig, David W|Sinari, Shripad|Moses, Tracy M|Christoforides, Alexis|Dinh, Jennifer|Izatt, Tyler|Aldrich, Jessica|Decker, Ardis|Baker, Angela|Cherni, Irene|Watanabe, April|Koep, Lawrence|Lake, Douglas|Hostetter, Galen|Trent, Jeffrey M|V
PMID: 22762308
Journal: Cancer Biol Ther. 2012 Aug;13(10):871-9.
Title: Exome sequencing and digital PCR analyses reveal novel mutated genes related to the metastasis of pancreatic ductal adenocarcinoma.
Author: Zhou, Bin|Irwanto, Astrid|Guo, Yun-Miao|Bei, Jin-Xin|Wu, Qiao|Chen, Ge|Zhang, Tai-Ping|Lei, Jin-Jv|Feng, Qi-Sheng|Chen, Li-Zhen|Liu, Jianjun|Zhao, Yu-Pei
PMID: 22797009
Journal: Biochem Biophys Res Commun. 2012 Aug 17;425(1):51-7.
Title: The regulatory roles of miRNA and methylation on oncogene and tumor suppressor gene expression in pancreatic cancer cells.
Author: Wang, Xianwei|Zhao, Jianfeng|Huang, Jianhua|Tang, Huihuan|Yu, Shuyi|Chen, Yuxiang
PMID: 22820191
Journal: Mol Cancer Res. 2012 Dec;10(12):1607-19.
Title: Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity.
Author: Gysin, Stephan|Paquette, Jesse|McMahon, Martin
PMID: 22833572
Journal: Expert Rev Anticancer Ther. 2012 Jul;12(7):881-4.
Title: Loss of miR-126 is crucial to pancreatic cancer progression.
Author: Frampton, Adam E|Krell, Jonathan|Jacob, Jimmy|Stebbing, Justin|Castellano, Leandro|Jiao, Long R
PMID: 22845403
Journal: Acta Cytol. 2012;56(4):439-47.
Title: Molecular analysis of centrifugation supernatant fluid from pancreaticobiliary duct samples can improve cancer detection.
Author: Finkelstein, Sydney D|Bibbo, Marluce|Loren, David E|Siddiqui, Ali A|Solomides, Charalambos|Kowalski, Thomas E|Ellsworth, Eric
PMID: 22846349
Journal: PLoS One. 2012;7(7):e40435.
Title: Sensitization of human pancreatic cancer cells harboring mutated K-ras to apoptosis.
Author: Shen, Ling|Kim, Sung-Hoon|Chen, Chang Yan
PMID: 22848379
Journal: World J Surg. 2012 Nov;36(11):2699-707.
Title: Prognostic microRNAs in cancer tissue from patients operated for pancreatic cancer--five microRNAs in a prognostic index.
Author: Schultz, Nicolai A|Andersen, Klaus K|Roslind, Anne|Willenbrock, Hanni|Wojdemann, Morten|Johansen, Julia S
PMID: 22851141
Journal: Mol Cell Biochem. 2012 Nov;370(1-2):127-39.
Title: Silencing expression of ribosomal protein L26 and L29 by RNA interfering inhibits proliferation of human pancreatic cancer PANC-1 cells.
Author: Li, Chaodong|Ge, Mei|Yin, Yu|Luo, Minyu|Chen, Daijie
PMID: 22868929
Journal: Mol Cancer Res. 2012 Sep;10(9):1228-39. Epub 2012 Aug 7.
Title: KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling.
Author: Appleman, Victoria A|Ahronian, Leanne G|Cai, JiuFeng|Klimstra, David S|Lewis, Brian C
PMID: 22871572
Journal: Clin Cancer Res. 2012 Aug 15;18(16):4285-90.
Title: Conceptual framework for cutting the pancreatic cancer fuel supply.
Author: Le, Anne|Rajeshkumar, N V|Maitra, Anirban|Dang, Chi V
PMID: 22896695
Journal: Cancer Cell. 2012 Sep 11;22(3):281-2.
Title: Ready, set, go: the EGF receptor at the pancreatic cancer starting line.
Author: Perera, Rushika M|Bardeesy, Nabeel
PMID: 22975369
Journal: Cancer Cell. 2012 Sep 11;22(3):318-30.
Title: EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.
Author: Navas, Carolina|Hernandez-Porras, Isabel|Schuhmacher, Alberto J|Sibilia, Maria|Guerra, Carmen|Barbacid, Mariano
PMID: 22975375
Journal: Clin Cancer Res. 2012 Nov 15;18(22):6339-47.
Title: Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors.
Author: Yachida, Shinichi|White, Catherine M|Naito, Yoshiki|Zhong, Yi|Brosnan, Jacqueline A|Macgregor-Das, Anne M|Morgan, Richard A|Saunders, Tyler|Laheru, Daniel A|Herman, Joseph M|Hruban, Ralph H|Klein, Alison P|Jones, Sian|Velculescu, Victor|Wolfgang, Christop
PMID: 22991414
Journal: Neoplasia. 2012 Sep;14(9):778-87.
Title: Inhibition of pancreatic intraepithelial neoplasia progression to carcinoma by nitric oxide-releasing aspirin in p48(Cre/+)-LSL-Kras(G12D/+) mice.
Author: Rao, Chinthalapally V|Mohammed, Altaf|Janakiram, Naveena B|Li, Qian|Ritchie, Rebekah L|Lightfoot, Stan|Vibhudutta, Awasthi|Steele, Vernon E
PMID: 23019409
Journal: Mol Cancer Res. 2012 Dec;10(12):1514-25.
Title: Reovirus: a targeted therapeutic--progress and potential.
Author: Maitra, Radhashree|Ghalib, Mohammad H|Goel, Sanjay
PMID: 23038811
Journal: Tumour Biol. 2012 Dec;33(6):1863-70.
Title: miR-143 inhibits the metastasis of pancreatic cancer and an associated signaling pathway.
Author: Hu, Yongjun|Ou, Yanglu|Wu, Kemin|Chen, Yuxiang|Sun, Weijia
PMID: 23070684
Journal: Sci Transl Med. 2012 Oct 17;4(156):156ra139.
Title: A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer.
Author: Chugh, Rohit|Sangwan, Veena|Patil, Satish P|Dudeja, Vikas|Dawra, Rajinder K|Banerjee, Sulagna|Schumacher, Robert J|Blazar, Bruce R|Georg, Gunda I|Vickers, Selwyn M|Saluja, Ashok K
PMID: 23076356
Journal: Cancer Gene Ther. 2012 Dec;19(12):862-9.
Title: Gene therapy of pancreatic cancer targeting the K-Ras oncogene.
Author: Lisiansky, V|Naumov, I|Shapira, S|Kazanov, D|Starr, A|Arber, N|Kraus, S
PMID: 23099885
Journal: J Hematol Oncol. 2012 Oct 26;5:68.
Title: Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy.
Author: Rachagani, Satyanarayana|Torres, Maria P|Kumar, Sushil|Haridas, Dhanya|Baine, Michael|Macha, Muzafar A|Kaur, Sukhwinder|Ponnusamy, Moorthy P|Dey, Parama|Seshacharyulu, Parthasarathy|Johansson, Sonny L|Jain, Maneesh|Wagner, Kay-Uwe|Batra, Surinder K
PMID: 23102107
Journal: Nature. 2012 Nov 15;491(7424):399-405.
Title: Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.
Author: Biankin, Andrew V|Waddell, Nicola|Kassahn, Karin S|Gingras, Marie-Claude|Muthuswamy, Lakshmi B|Johns, Amber L|Miller, David K|Wilson, Peter J|Patch, Ann-Marie|Wu, Jianmin|Chang, David K|Cowley, Mark J|Gardiner, Brooke B|Song, Sarah|Harliwong, Ivon|Idrisog
PMID: 23103869
Journal: Front Physiol. 2012 Nov 14;3:430.
Title: MSX2 in pancreatic tumor development and its clinical application for the diagnosis of pancreatic ductal adenocarcinoma.
Author: Satoh, Kennichi|Hamada, Shin|Shimosegawa, Tooru
PMID: 23162473
Journal: Oncotarget. 2012 Nov;3(11):1262-3.
Title: KRAS above and beyond - EGFR in pancreatic cancer.
Author: Siveke, Jens T|Crawford, Howard C
PMID: 23174662
Journal: Gastroenterol Res Pract. 2012;2012:243524.
Title: Molecular Biologic Approach to the Diagnosis of Pancreatic Carcinoma Using Specimens Obtained by EUS-Guided Fine Needle Aspiration.
Author: Kato, Kiyohito|Kamada, Hideki|Fujimori, Takayuki|Aritomo, Yuuichi|Ono, Masahiro|Masaki, Tsutomu
PMID: 23197977
Journal: Coll Antropol. 2012 Sep;36(3):1063-7.
Title: Etiology and oncogenesis of pancreatic carcinoma.
Author: Dobrila-Dintinjana, Renata|Vanis, Nenad|Dintinjana, Marijan|Radic, Mladen
PMID: 23213974
Journal: PLoS One. 2012;7(12):e49707.
Title: Metastatic pancreatic cancer is dependent on oncogenic Kras in mice.
Author: Collins, Meredith A|Brisset, Jean-Christophe|Zhang, Yaqing|Bednar, Filip|Pierre, Josette|Heist, Kevin A|Galban, Craig J|Galban, Stefanie|di Magliano, Marina Pasca
PMID: 23226501
Journal: Adv Exp Med Biol. 2012;771:229-39.
Title: Pancreatic cancer and diabetes.
Author: Morrison, Maureen
PMID: 23393682
Journal: Mol Carcinog. 2013 Jul;52(7):555-67.
Title: Regulation of pancreatic cancer growth by superoxide.
Author: Du, Juan|Nelson, Elke S|Simons, Andrean L|Olney, Kristen E|Moser, Justin C|Schrock, Hannah E|Wagner, Brett A|Buettner, Garry R|Smith, Brian J|Teoh, Melissa L T|Tsao, Ming-Sound|Cullen, Joseph J
PMID: 22392697
Journal: Mol Carcinog. 2013 Sep;52(9):739-50.
Title: Atorvastatin inhibits pancreatic carcinogenesis and increases survival in LSL-KrasG12D-LSL-Trp53R172H-Pdx1-Cre mice.
Author: Liao, Jie|Chung, Yeon T|Yang, Allison L|Zhang, Meng|Li, Haonan|Zhang, Wanying|Yan, Liang|Yang, Guang-Yu
PMID: 22549877
Journal: Pancreas. 2013 Jan;42(1):160-7.
Title: Efficacy of dimethylaminoparthenolide and sulindac in combination with gemcitabine in a genetically engineered mouse model of pancreatic cancer.
Author: Yip-Schneider, Michele T|Wu, Huangbing|Hruban, Ralph H|Lowy, Andrew M|Crooks, Peter A|Schmidt, Christian Max
PMID: 22699205
Journal: Oncogene. 2013 May 16;32(20):2576-85.
Title: RREB1 repressed miR-143/145 modulates KRAS signaling through downregulation of multiple targets.
Author: Kent, O A|Fox-Talbot, K|Halushka, M K
PMID: 22751122
Journal: Oncogene. 2013 May 23;32(21):2690-5.
Title: Requirement of NEMO/IKKgamma for effective expansion of KRAS-induced precancerous lesions in the pancreas.
Author: Maier, H J|Wagner, M|Schips, T G|Salem, H H|Baumann, B|Wirth, T
PMID: 22751123
Journal: Gut. 2013 May;62(5):751-9.
Title: Gemcitabine plus erlotinib followed by capecitabine versus capecitabine plus erlotinib followed by gemcitabine in advanced pancreatic cancer: final results of a randomised phase 3 trial of the 'Arbeitsgemeinschaft Internistische Onkologie' (AIO-PK0104).
Author: Heinemann, Volker|Vehling-Kaiser, Ursula|Waldschmidt, Dirk|Kettner, Erika|Marten, Angela|Winkelmann, Cornelia|Klein, Stefan|Kojouharoff, Georgi|Gauler, Thomas C|von Weikersthal, Ludwig Fischer|Clemens, Michael R|Geissler, Michael|Greten, Tim F|Hegewisch-B
PMID: 22773551
Journal: Oncogene. 2013 Aug 15;32(33):3867-76.
Title: AGR2 is a SMAD4-suppressible gene that modulates MUC1 levels and promotes the initiation and progression of pancreatic intraepithelial neoplasia.
Author: Norris, A M|Gore, A|Balboni, A|Young, A|Longnecker, D S|Korc, M
PMID: 22945649
Journal: Exp Cell Res. 2013 Feb 1;319(3):105-12.
Title: Involvement of oncogenic K-ras on cell migration stimulated by lysophosphatidic acid receptor-2 in pancreatic cancer cells.
Author: Yoshikawa, Kyohei|Tanabe, Eriko|Shibata, Ayano|Inoue, Serina|Kitayoshi, Misaho|Okimoto, Souta|Fukushima, Nobuyuki|Tsujiuchi, Toshifumi
PMID: 23041208
Journal: J Clin Pathol. 2013 Mar;66(3):192-7.
Title: Genetic and epigenetic markers in the evaluation of pancreatic masses.
Author: Ginesta, Mireia M|Mora, Josefina|Mayor, Regina|Farre, Antoni|Peinado, Miquel Angel|Busquets, Juli|Serrano, Teresa|Capella, Gabriel|Fabregat, Joan
PMID: 23135349
Journal: Br J Cancer. 2013 Feb 5;108(2):469-76.
Title: EGFR pathway biomarkers in erlotinib-treated patients with advanced pancreatic cancer: translational results from the randomised, crossover phase 3 trial AIO-PK0104.
Author: Boeck, S|Jung, A|Laubender, R P|Neumann, J|Egg, R|Goritschan, C|Vehling-Kaiser, U|Winkelmann, C|Fischer von Weikersthal, L|Clemens, M R|Gauler, T C|Marten, A|Klein, S|Kojouharoff, G|Barner, M|Geissler, M|Greten, T F|Mansmann, U|Kirchner, T|Heinemann, V
PMID: 23169292
Journal: Pancreas. 2013 Apr;42(3):411-21.
Title: Molecular markers for novel therapeutic strategies in pancreatic endocrine tumors.
Author: Gilbert, Judith A|Adhikari, Laura J|Lloyd, Ricardo V|Halfdanarson, Thorvardur R|Muders, Michael H|Ames, Matthew M
PMID: 23211371
Journal: Cancer Sci. 2013 Mar;104(3):337-44.
Title: Therapeutic effect of c-Jun N-terminal kinase inhibition on pancreatic cancer.
Author: Takahashi, Ryota|Hirata, Yoshihiro|Sakitani, Kosuke|Nakata, Wachiko|Kinoshita, Hiroto|Hayakawa, Yoku|Nakagawa, Hayato|Sakamoto, Kei|Hikiba, Yohko|Ijichi, Hideaki|Moses, Harold L|Maeda, Shin|Koike, Kazuhiko
PMID: 23237571
Journal: Clin Gastroenterol Hepatol. 2013 Apr;11(4):425-9.
Title: Association between KRAS mutation, detected in pancreatic cyst fluid, and long-term outcomes of patients.
Author: Rockacy, Matthew J|Zahid, Maliha|McGrath, Kevin M|Fasanella, Kenneth E|Khalid, Asif
PMID: 23267865
Journal: Mol Cancer Ther. 2013 Mar;12(3):286-94.
Title: Targeted degradation of KRAS by an engineered ubiquitin ligase suppresses pancreatic cancer cell growth in vitro and in vivo.
Author: Ma, Yihui|Gu, Yumei|Zhang, Qiang|Han, Yongqing|Yu, Shuangni|Lu, Zhaohui|Chen, Jie
PMID: 23288781
Journal: Carcinogenesis. 2013 Apr;34(4):858-63.
Title: Prolonged survival and delayed progression of pancreatic intraepithelial neoplasia in LSL-KrasG12D/+;Pdx-1-Cre mice by vitamin E delta-tocotrienol.
Author: Husain, Kazim|Centeno, Barbara A|Chen, Dung-Tsa|Fulp, William J|Perez, Marta|Zhang Lee, Guo|Luetteke, Noreen|Hingorani, Sunil R|Sebti, Said M|Malafa, Mokenge P
PMID: 23302291
Journal: Pediatr Blood Cancer. 2013 May;60(5):754-60.
Title: Molecular characteristics of a pancreatic adenocarcinoma associated with Shwachman-Diamond syndrome.
Author: Dhanraj, Santhosh|Manji, Arif|Pinto, Dalila|Scherer, Stephen W|Favre, Helen|Loh, Mignon L|Chetty, Runjan|Wei, Alice C|Dror, Yigal
PMID: 23303473
Journal: Gastroenterology. 2013 May;144(5):1098-106.
Title: Vaccination with ENO1 DNA prolongs survival of genetically engineered mice with pancreatic cancer.
Author: Cappello, Paola|Rolla, Simona|Chiarle, Roberto|Principe, Moitza|Cavallo, Federica|Perconti, Giovanni|Feo, Salvatore|Giovarelli, Mirella|Novelli, Francesco
PMID: 23333712
Journal: Pancreas. 2013 Mar;42(2):216-22.
Title: Genetic alterations of K-ras, p53, c-erbB-2, and DPC4 in pancreatic ductal adenocarcinoma and their correlation with patient survival.
Author: Shin, Sang Hyun|Kim, Song Cheol|Hong, Seung-Mo|Kim, Young Hoon|Song, Ki-Byung|Park, Kwang-Min|Lee, Young-Joo
PMID: 23344532
Journal: Genes Dev. 2013 Feb 1;27(3):288-300.
Title: The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis.
Author: Reichert, Maximilian|Takano, Shigetsugu|von Burstin, Johannes|Kim, Sang-Bae|Lee, Ju-Seog|Ihida-Stansbury, Kaori|Hahn, Christopher|Heeg, Steffen|Schneider, Gunter|Rhim, Andrew D|Stanger, Ben Z|Rustgi, Anil K
PMID: 23355395
Journal: Cancer Res. 2013 Mar 15;73(6):1811-20.
Title: Phosphorylation of ribosomal protein S6 attenuates DNA damage and tumor suppression during development of pancreatic cancer.
Author: Khalaileh, Abed|Dreazen, Avigail|Khatib, Areej|Apel, Roy|Swisa, Avital|Kidess-Bassir, Norma|Maitra, Anirban|Meyuhas, Oded|Dor, Yuval|Zamir, Gideon
PMID: 23361300
Journal: Cancer Res. 2013 Apr 1;73(7):2221-34.
Title: Erlotinib prolongs survival in pancreatic cancer by blocking gemcitabine-induced MAPK signals.
Author: Miyabayashi, Koji|Ijichi, Hideaki|Mohri, Dai|Tada, Motohisa|Yamamoto, Keisuke|Asaoka, Yoshinari|Ikenoue, Tsuneo|Tateishi, Keisuke|Nakai, Yousuke|Isayama, Hiroyuki|Morishita, Yasuyuki|Omata, Masao|Moses, Harold L|Koike, Kazuhiko
PMID: 23378339
Journal: Cancer Discov. 2013 Mar;3(3):280-93.
Title: Outlier kinase expression by RNA sequencing as targets for precision therapy.
Author: Kothari, Vishal|Wei, Iris|Shankar, Sunita|Kalyana-Sundaram, Shanker|Wang, Lidong|Ma, Linda W|Vats, Pankaj|Grasso, Catherine S|Robinson, Dan R|Wu, Yi-Mi|Cao, Xuhong|Simeone, Diane M|Chinnaiyan, Arul M|Kumar-Sinha, Chandan
PMID: 23384775
Journal: Br J Cancer. 2013 Mar 5;108(4):951-8.
Title: Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms.
Author: Nishikawa, G|Sekine, S|Ogawa, R|Matsubara, A|Mori, T|Taniguchi, H|Kushima, R|Hiraoka, N|Tsuta, K|Tsuda, H|Kanai, Y
PMID: 23403822
Journal: Oncol Lett. 2013 Mar;5(3):1000-1004.
Title: Differential expression of RBM5 and KRAS in pancreatic ductal adenocarcinoma and their association with clinicopathological features.
Author: Peng, Jie|Valeshabad, Ali Kord|Li, Qingfu|Wang, Yuan
PMID: 23425895
Journal: Small. 2013 Aug 26;9(16):2757-63.
Title: Biodegradable nanocapsules as siRNA carriers for mutant K-Ras gene silencing of human pancreatic carcinoma cells.
Author: Lin, Guimiao|Hu, Rui|Law, Wing-Cheung|Chen, Chih-Kuang|Wang, Yucheng|Li Chin, Hui|Nguyen, Quoc Toan|Lai, Cheng Kee|Yoon, Ho Sup|Wang, Xiaomei|Xu, Gaixia|Ye, Ling|Cheng, Chong|Yong, Ken-Tye
PMID: 23427041
Journal: J Gastroenterol. 2013 Apr;48(4):544-8.
Title: KRAS mutation status is not predictive for objective response to anti-EGFR treatment with erlotinib in patients with advanced pancreatic cancer.
Author: Boeck, Stefan|Jung, Andreas|Laubender, Rudiger P|Neumann, Jens|Egg, Rosalind|Goritschan, Clara|Ormanns, Steffen|Haas, Michael|Modest, Dominik P|Kirchner, Thomas|Heinemann, Volker
PMID: 23435671
Journal: Cancer Res. 2013 Apr 15;73(8):2529-39.
Title: PARI overexpression promotes genomic instability and pancreatic tumorigenesis.
Author: O'Connor, Kevin W|Dejsuphong, Donniphat|Park, Eunmi|Nicolae, Claudia M|Kimmelman, Alec C|D'Andrea, Alan D|Moldovan, George-Lucian
PMID: 23436799
Journal: Neoplasia. 2013 Feb;15(2):143-55.
Title: Inhibition of the growth of patient-derived pancreatic cancer xenografts with the MEK inhibitor trametinib is augmented by combined treatment with the epidermal growth factor receptor/HER2 inhibitor lapatinib.
Author: Walters, Dustin M|Lindberg, James M|Adair, Sara J|Newhook, Timothy E|Cowan, Catharine R|Stokes, Jayme B|Borgman, Cheryl A|Stelow, Edward B|Lowrey, Bryce T|Chopivsky, Maria E|Gilmer, Tona M|Parsons, John T|Bauer, Todd W
PMID: 23441129
Journal: Cancer Res. 2013 Mar 15;73(6):1821-30.
Title: Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.
Author: Lin, Wan-chi|Rajbhandari, Nirakar|Liu, Chengbao|Sakamoto, Kazuhito|Zhang, Qian|Triplett, Aleata A|Batra, Surinder K|Opavsky, Rene|Felsher, Dean W|DiMaio, Dominick J|Hollingsworth, Michael A|Morris, John P 4th|Hebrok, Matthias|Witkiewicz, Agnieszka K|Brody
PMID: 23467612
Journal: Oncotarget. 2013 Feb;4(2):277-88.
Title: Efemp1 and p27(Kip1) modulate responsiveness of pancreatic cancer cells towards a dual PI3K/mTOR inhibitor in preclinical models.
Author: Diersch, Sandra|Wenzel, Patrick|Szameitat, Melanie|Eser, Philipp|Paul, Mariel C|Seidler, Barbara|Eser, Stefan|Messer, Marlena|Reichert, Maximilian|Pagel, Philipp|Esposito, Irene|Schmid, Roland M|Saur, Dieter|Schneider, Gunter
PMID: 23470560
Journal: Nucleic Acids Res. 2013 Apr;41(7):4049-64.
Title: MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice.
Author: Cogoi, Susanna|Zorzet, Sonia|Rapozzi, Valentina|Geci, Imrich|Pedersen, Erik B|Xodo, Luigi E
PMID: 23471001
Journal: Mol Cancer Ther. 2013 Jun;12(6):853-64.
Title: Bcl-2/Bcl-xL inhibition increases the efficacy of MEK inhibition alone and in combination with PI3 kinase inhibition in lung and pancreatic tumor models.
Author: Tan, Nguyen|Wong, Maureen|Nannini, Michelle A|Hong, Rebecca|Lee, Leslie B|Price, Stephen|Williams, Karen|Savy, Pierre Pascal|Yue, Peng|Sampath, Deepak|Settleman, Jeffrey|Fairbrother, Wayne J|Belmont, Lisa D
PMID: 23475955
Journal: J Biol Chem. 2013 Apr 26;288(17):11786-94.
Title: Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation.
Author: Mills, Lisa D|Zhang, Yaqing|Marler, Ronald J|Herreros-Villanueva, Marta|Zhang, Lizhi|Almada, Luciana L|Couch, Fergus|Wetmore, Cynthia|Pasca di Magliano, Marina|Fernandez-Zapico, Martin E
PMID: 23482563
Journal: Pancreas. 2013 Apr;42(3):543-4.
Title: KRAS mutations and their correlation with survival of patients with advanced pancreatic cancer.
Author: Bournet, Barbara|Muscari, Fabrice|Guimbaud, Rosine|Cordelier, Pierre|Buscail, Louis
PMID: 23486365
Journal: Mol Oncol. 2013 Apr;7(2):232-47.
Title: Genetically engineered mouse models of pancreatic adenocarcinoma.
Author: Guerra, Carmen|Barbacid, Mariano
PMID: 23506980
Journal: Pathol Int. 2013 Mar;63(3):176-82.
Title: BCL10 as a useful marker for pancreatic acinar cell carcinoma, especially using endoscopic ultrasound cytology specimens.
Author: Hosoda, Waki|Sasaki, Eiichi|Murakami, Yoshiko|Yamao, Kenji|Shimizu, Yasuhiro|Yatabe, Yasushi
PMID: 23530562
Journal: Ann Surg. 2013 Jul;258(1):141-51.
Title: Intraductal papillary mucinous neoplasms of the pancreas with distinct pancreatic ductal adenocarcinomas are frequently of gastric subtype.
Author: Ideno, Noboru|Ohtsuka, Takao|Kono, Hiroshi|Fujiwara, Kenji|Oda, Yasunori|Aishima, Shinichi|Ito, Tetsuhide|Ishigami, Kousei|Tokunaga, Shoji|Ohuchida, Kenoki|Takahata, Shunichi|Nakamura, Masafumi|Mizumoto, Kazuhiro|Tanaka, Masao
PMID: 23532108
Journal: Cancer Discov. 2013 Jun;3(6):690-703.
Title: GSK-3alpha promotes oncogenic KRAS function in pancreatic cancer via TAK1-TAB stabilization and regulation of noncanonical NF-kappaB.
Author: Bang, Deepali|Wilson, Willie|Ryan, Meagan|Yeh, Jen Jen|Baldwin, Albert S
PMID: 23547054
Journal: Hepatobiliary Pancreat Dis Int. 2013 Apr;12(2):204-9.
Title: Decreased expression of DAB2IP in pancreatic cancer with wild-type KRAS.
Author: Duan, Yi-Fan|Li, Dong-Feng|Liu, Yan-Hui|Mei, Ping|Qin, Yu-Xuan|Li, Liang-Fang|Lin, Qiu-Xiong|Li, Zi-Jun
PMID: 23558076
Journal: PLoS One. 2013;8(4):e60870.
Title: Somatic mutations in exocrine pancreatic tumors: association with patient survival.
Author: Rachakonda, P Sivaramakrishna|Bauer, Andrea S|Xie, Huaping|Campa, Daniele|Rizzato, Cosmeri|Canzian, Federico|Beghelli, Stefania|Greenhalf, William|Costello, Eithne|Schanne, Michaela|Heller, Anette|Scarpa, Aldo|Neoptolemos, John P|Werner, Jens|Buchler, Mar
PMID: 23565280
Journal: Am J Pathol. 2013 Jun;182(6):1996-2004.
Title: Oxidative stress induced by inactivation of TP53INP1 cooperates with KrasG12D to initiate and promote pancreatic carcinogenesis in the murine pancreas.
Author: Al Saati, Talal|Clerc, Pascal|Hanoun, Naima|Peuget, Sylvain|Lulka, Hubert|Gigoux, Veronique|Capilla, Florence|Beluchon, Benoit|Couvelard, Anne|Selves, Janick|Buscail, Louis|Carrier, Alice|Dusetti, Nelson|Dufresne, Marlene
PMID: 23578383
Journal: Int J Oncol. 2013 Jun;42(6):1869-74.
Title: Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7.
Author: Cheng, Shujie|Eliaz, Isaac|Lin, Junfang|Thyagarajan-Sahu, Anita|Sliva, Daniel
PMID: 23588713
Journal: BMC Cancer. 2013 Apr 17;13:194.
Title: Dimethylaminoparthenolide and gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer.
Author: Yip-Schneider, Michele T|Wu, Huangbing|Stantz, Keith|Agaram, Narasimhan|Crooks, Peter A|Schmidt, C Max
PMID: 23590467
Journal: J Surg Res. 2013 Sep;184(1):290-8.
Title: In vivo serial selection of human pancreatic cancer cells in orthotopic mouse models produces high metastatic variants irrespective of Kras status.
Author: Metildi, Cristina A|Kaushal, Sharmeela|Hoffman, Robert M|Bouvet, Michael
PMID: 23590868
Journal: Mod Pathol. 2013 Oct;26(10):1346-54.
Title: KRAS mutant allele-specific imbalance is associated with worse prognosis in pancreatic cancer and progression to undifferentiated carcinoma of the pancreas.
Author: Krasinskas, Alyssa M|Moser, A James|Saka, Burcu|Adsay, N Volkan|Chiosea, Simion I
PMID: 23599154
Journal: PLoS One. 2013 Apr 16;8(4):e61977.
Title: Anti-pancreatic cancer deliverables from sea: first-hand evidence on the efficacy, molecular targets and mode of action for multifarious polyphenols from five different brown-algae.
Author: Aravindan, Sheeja|Delma, Caroline R|Thirugnanasambandan, Somasundaram S|Herman, Terence S|Aravindan, Natarajan
PMID: 23613993
Journal: Gastroenterology. 2013 Jun;144(6):1220-9.
Title: Roles for KRAS in pancreatic tumor development and progression.
Author: di Magliano, Marina Pasca|Logsdon, Craig D
PMID: 23622131
Journal: Mol Cancer Ther. 2013 Jul;12(7):1190-201.
Title: PG545, an angiogenesis and heparanase inhibitor, reduces primary tumor growth and metastasis in experimental pancreatic cancer.
Author: Ostapoff, Katherine T|Awasthi, Niranjan|Cenik, Bercin Kutluk|Hinz, Stefan|Dredge, Keith|Schwarz, Roderich E|Brekken, Rolf A
PMID: 23696215
Journal: Int J Cancer. 2013 Dec 1;133(11):2662-71.
Title: Mass profiling of serum to distinguish mice with pancreatic cancer induced by a transgenic Kras mutation.
Author: Hocker, James R|Mohammed, Altaf|Aston, Christopher E|Brewer, Misty|Lightfoot, Stan A|Rao, Chinthalapally V|Hanas, Jay S
PMID: 23712558
Journal: Clin Res Hepatol Gastroenterol. 2013 Sep;37(4):320-1.
Title: Increase in PI3K signalling mimics mutated-Kras induction of pancreatic cancer.
Author: Baer, R|Pyronnet, S|Guillermet-Guibert, J
PMID: 23746401
Journal: Cancer Discov. 2013 Jun;3(6):613-5.
Title: A new alpha in line between KRAS and NF-kappaB activation?
Author: Pak, Chorom|Miyamoto, Shigeki
PMID: 23749528
Journal: Cancer Res. 2013 Aug 1;73(15):4781-90.
Title: PanIN-specific regulation of Wnt signaling by HIF2alpha during early pancreatic tumorigenesis.
Author: Criscimanna, Angela|Duan, Li-Juan|Rhodes, Julie A|Fendrich, Volker|Wickline, Emily|Hartman, Douglas J|Monga, Satdarshan P S|Lotze, Michael T|Gittes, George K|Fong, Guo-Hua|Esni, Farzad
PMID: 23749643
Journal: Mol Cancer Res. 2013 Sep;11(9):1078-87.
Title: Snail cooperates with KrasG12D to promote pancreatic fibrosis.
Author: Shields, Mario A|Ebine, Kazumi|Sahai, Vaibhav|Kumar, Krishan|Siddiqui, Kulsumjehan|Hwang, Rosa F|Grippo, Paul J|Munshi, Hidayatullah G
PMID: 23761168
Journal: Pancreas. 2013 Jul;42(5):740-59.
Title: Sweating the small stuff: microRNAs and genetic changes define pancreatic cancer.
Author: Tang, Siuwah|Bonaroti, Jillian|Unlu, Sebnem|Liang, Xiaoyan|Tang, Daolin|Zeh, Herbert J|Lotze, Michael T
PMID: 23774697
Journal: Mol Cancer. 2013 Jun 20;12:66.
Title: Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner.
Author: Lei, Jianjun|Ma, Jiguang|Ma, Qingyong|Li, Xuqi|Liu, Han|Xu, Qinhong|Duan, Wanxing|Sun, Qing|Xu, Jun|Wu, Zheng|Wu, Erxi
PMID: 23786654
Journal: Histopathology. 2013 Aug;63(2):157-66.
Title: Fibroblast growth factor receptor 1 gene amplification in pancreatic ductal adenocarcinoma.
Author: Lehnen, Nils C|von Massenhausen, Anne|Kalthoff, Holger|Zhou, Hui|Glowka, Tim|Schutte, Ute|Holler, Tobias|Riesner, Katarina|Boehm, Diana|Merkelbach-Bruse, Sabine|Kirfel, Jutta|Perner, Sven|Gutgemann, Ines
PMID: 23808822
Journal: PLoS One. 2013 Jun 28;8(6):e67330.
Title: Anti-tumour efficacy of capecitabine in a genetically engineered mouse model of pancreatic cancer.
Author: Courtin, Aurelie|Richards, Frances M|Bapiro, Tashinga E|Bramhall, Jo L|Neesse, Albrecht|Cook, Natalie|Krippendorff, Ben-Fillippo|Tuveson, David A|Jodrell, Duncan I
PMID: 23840665
Journal: Cell Death Dis. 2013 Jul 18;4:e728.
Title: Reolysin is a novel reovirus-based agent that induces endoplasmic reticular stress-mediated apoptosis in pancreatic cancer.
Author: Carew, J S|Espitia, C M|Zhao, W|Kelly, K R|Coffey, M|Freeman, J W|Nawrocki, S T
PMID: 23868061
Journal: Cancer Lett. 2013 Oct 1;339(1):135-43.
Title: The biological features of PanIN initiated from oncogenic Kras mutation in genetically engineered mouse models.
Author: Shen, Ruizhe|Wang, Qi|Cheng, Shidan|Liu, Tingting|Jiang, He|Zhu, Jiaxing|Wu, Yunlin|Wang, Lifu
PMID: 23887057
Journal: Cancer Cytopathol. 2013 Dec;121(12):688-94.
Title: Clinical next-generation sequencing successfully applied to fine-needle aspirations of pulmonary and pancreatic neoplasms.
Author: Young, Geneva|Wang, Kai|He, Jie|Otto, Geoff|Hawryluk, Matthew|Zwirco, Zac|Brennan, Tina|Nahas, Michelle|Donahue, Amy|Yelensky, Roman|Lipson, Doron|Sheehan, Christine E|Boguniewicz, Ann B|Stephens, Philip J|Miller, Vincent A|Ross, Jeffrey S
PMID: 23893923
Journal: Gastroenterology. 2013 Nov;145(5):1098-1109.e1.
Title: Genetic alterations associated with progression from pancreatic intraepithelial neoplasia to invasive pancreatic tumor.
Author: Murphy, Stephen J|Hart, Steven N|Lima, Joema Felipe|Kipp, Benjamin R|Klebig, Mitchell|Winters, Jennifer L|Szabo, Csilla|Zhang, Lizhi|Eckloff, Bruce W|Petersen, Gloria M|Scherer, Steven E|Gibbs, Richard A|McWilliams, Robert R|Vasmatzis, George|Couch, Fergu
PMID: 23912084
Journal: Mol Cancer Ther. 2013 Oct;12(10):2213-25.
Title: Subtype-specific MEK-PI3 kinase feedback as a therapeutic target in pancreatic adenocarcinoma.
Author: Mirzoeva, Olga K|Collisson, Eric A|Schaefer, Peter M|Hann, Byron|Hom, Yun K|Ko, Andrew H|Korn, W Michael
PMID: 23918833
Journal: Zhonghua Bing Li Xue Za Zhi. 2013 Apr;42(4):248-51.
Title: [Intraductal tubulopapillary neoplasm of the pancreas: a clinicopathologic study of 6 cases].
Author: Chang, Xiao-yan|Lu, Zhao-hui|Li, Xing-qi|Chen, Jie
PMID: 23928532
Journal: Cancer Chemother Pharmacol. 2013 Sep;72(3):669-82.
Title: The association between the expression of solute carrier transporters and the prognosis of pancreatic cancer.
Author: Mohelnikova-Duchonova, Beatrice|Brynychova, Veronika|Hlavac, Viktor|Kocik, Matej|Oliverius, Martin|Hlavsa, Jan|Honsova, Eva|Mazanec, Jan|Kala, Zdenek|Melichar, Bohuslav|Soucek, Pavel
PMID: 23934321
Journal: Cancer Prev Res (Phila). 2013 Oct;6(10):1074-83.
Title: Vitamin E delta-tocotrienol prolongs survival in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) transgenic mouse model of pancreatic cancer.
Author: Husain, Kazim|Centeno, Barbara A|Chen, Dung-Tsa|Hingorani, Sunil R|Sebti, Said M|Malafa, Mokenge P
PMID: 23963802
Journal: Cancer Prev Res (Phila). 2013 Oct;6(10):1046-55.
Title: Dietary energy balance modulation of Kras- and Ink4a/Arf+/--driven pancreatic cancer: the role of insulin-like growth factor-I.
Author: Lashinger, Laura M|Harrison, Lauren M|Rasmussen, Audrey J|Logsdon, Craig D|Fischer, Susan M|McArthur, Mark J|Hursting, Stephen D
PMID: 23980075
Journal: Langenbecks Arch Surg. 2013 Oct;398(7):989-96.
Title: Aspirin prolongs survival and reduces the number of Foxp3+ regulatory T cells in a genetically engineered mouse model of pancreatic cancer.
Author: Plassmeier, Lars|Knoop, Richard|Waldmann, Jens|Kesselring, Rebecca|Buchholz, Malte|Fichtner-Feigl, Stefan|Bartsch, Detlef K|Fendrich, Volker
PMID: 23989613
Journal: PLoS One. 2013 Sep 9;8(9):e73940.
Title: DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer.
Author: Sureban, Sripathi M|May, Randal|Qu, Dongfeng|Weygant, Nathaniel|Chandrakesan, Parthasarathy|Ali, Naushad|Lightfoot, Stan A|Pantazis, Panayotis|Rao, Chinthalapally V|Postier, Russell G|Houchen, Courtney W
PMID: 24040120
Journal: BMC Genomics. 2013 Sep 16;14:624.
Title: Integrative genomic and functional profiling of the pancreatic cancer genome.
Author: Shain, A Hunter|Salari, Keyan|Giacomini, Craig P|Pollack, Jonathan R
PMID: 24041470
Journal: Biochem Biophys Res Commun. 2013 Oct 11;440(1):50-5.
Title: Trisomy of the Dscr1 gene suppresses early progression of pancreatic intraepithelial neoplasia driven by oncogenic Kras.
Author: Lee, Jang Choon|Shin, Jimin|Baek, Kwan-Hyuck
PMID: 24041692
Journal: JAKSTAT. 2013 Jan 1;2(1):e23011.
Title: TLR7 inhibition: A novel strategy for pancreatic cancer treatment?
Author: Eigenbrod, Tatjana|Dalpke, Alexander H
PMID: 24058792
Journal: Pancreatology. 2013 Sep-Oct;13(5):502-7.
Title: Simvastatin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer.
Author: Fendrich, Volker|Sparn, Moritz|Lauth, Matthias|Knoop, Richard|Plassmeier, Lars|Bartsch, Detlef K|Waldmann, Jens
PMID: 24075515
Journal: Cancer Res. 2013 Oct 15;73(20):6359-74.
Title: Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance.
Author: Zhang, Yaqing|Yan, Wei|Collins, Meredith A|Bednar, Filip|Rakshit, Sabita|Zetter, Bruce R|Stanger, Ben Z|Chung, Ivy|Rhim, Andrew D|di Magliano, Marina Pasca
PMID: 24097820
Journal: PLoS One. 2013 Oct 9;8(10):e77243.
Title: Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models.
Author: Zhong, Hua|Sanchez, Cesar|Spitzer, Dirk|Plambeck-Suess, Stacy|Gibbs, Jesse|Hawkins, Williams G|Denardo, David|Gao, Feng|Pufahl, Robert A|Lockhart, Albert C|Xu, Mai|Linehan, David|Weber, Jason|Wang-Gillam, Andrea
PMID: 24130864
Journal: Pancreas. 2013 Nov;42(8):1218-26.
Title: Pancreatic cancer: modulation of KRAS, MicroRNAs, and intercellular communication in the setting of tumor heterogeneity.
Author: Lou, Emil|Subramanian, Subbaya|Steer, Clifford J
PMID: 24152947
Journal: PLoS One. 2013 Oct 23;8(10):e78183.
Title: Development and histopathological characterization of tumorgraft models of pancreatic ductal adenocarcinoma.
Author: Garcia, Patrick L|Council, Leona N|Christein, John D|Arnoletti, J Pablo|Heslin, Marty J|Gamblin, Tracy L|Richardson, Joseph H|Bjornsti, Mary-Ann|Yoon, Karina J
PMID: 24194913
Journal: Pathologe. 2013 Nov;34 Suppl 2:214-20.
Title: [Will molecular diagnostics become established in pancreatic pathology?].
Author: Sipos, B|Sperveslage, J
PMID: 24196616
Journal: Neoplasia. 2013 Oct;15(10):1184-95.
Title: A novel Ras inhibitor (MDC-1016) reduces human pancreatic tumor growth in mice.
Author: Mackenzie, Gerardo G|Bartels, Lauren E|Xie, Gang|Papayannis, Ioannis|Alston, Ninche|Vrankova, Kvetoslava|Ouyang, Nengtai|Rigas, Basil
PMID: 24204197
Journal: PLoS One. 2013 Oct 18;8(10):e77065.
Title: Clinical, molecular and genetic validation of a murine orthotopic xenograft model of pancreatic adenocarcinoma using fresh human specimens.
Author: Walters, Dustin M|Stokes, Jayme B|Adair, Sara J|Stelow, Edward B|Borgman, Cheryl A|Lowrey, Bryce T|Xin, Wenjun|Blais, Edik M|Lee, Jae K|Papin, Jason A|Parsons, J Thomas|Bauer, Todd W
PMID: 24204737
Journal: J Clin Invest. 2013 Nov;123(11):4681-94.
Title: Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression.
Author: Court, Helen|Amoyel, Marc|Hackman, Michael|Lee, Kyoung Eun|Xu, Ruliang|Miller, George|Bar-Sagi, Dafna|Bach, Erika A|Bergo, Martin O|Philips, Mark R
PMID: 24216479
Journal: Sci Rep. 2013 Nov 15;3:3230.
Title: mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions.
Author: Matsubara, Shyuichiro|Ding, Qiang|Miyazaki, Yumi|Kuwahata, Taisaku|Tsukasa, Koichiro|Takao, Sonshin
PMID: 24231729
Journal: PLoS One. 2013 Nov 20;8(11):e80580.
Title: Novel pancreatic cancer cell lines derived from genetically engineered mouse models of spontaneous pancreatic adenocarcinoma: applications in diagnosis and therapy.
Author: Torres, Maria P|Rachagani, Satyanarayana|Souchek, Joshua J|Mallya, Kavita|Johansson, Sonny L|Batra, Surinder K
PMID: 24278292
Journal: Med Sci (Paris). 2013 Nov;29(11):991-7.
Title: [Kras oncogene and pancreatic cancer: thirty years after].
Author: Bournet, Barbara|Dufresne, Marlene|Selves, Janick|Torrisani, Jerome|Cordelier, Pierre|Buscail, Louis
PMID: 24280502
Journal: Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20723-8.
Title: Mutant KRAS is a druggable target for pancreatic cancer.
Author: Zorde Khvalevsky, Elina|Gabai, Racheli|Rachmut, Itzhak Haim|Horwitz, Elad|Brunschwig, Zivia|Orbach, Ariel|Shemi, Adva|Golan, Talia|Domb, Abraham J|Yavin, Eylon|Giladi, Hilla|Rivkin, Ludmila|Simerzin, Alina|Eliakim, Rami|Khalaileh, Abed|Hubert, Ayala|Lahav
PMID: 24297898
Journal: Nature. 2013 Dec 12;504(7479):296-300.
Title: p53 status determines the role of autophagy in pancreatic tumour development.
Author: Rosenfeldt, Mathias T|O'Prey, Jim|Morton, Jennifer P|Nixon, Colin|MacKay, Gillian|Mrowinska, Agata|Au, Amy|Rai, Taranjit Singh|Zheng, Liang|Ridgway, Rachel|Adams, Peter D|Anderson, Kurt I|Gottlieb, Eyal|Sansom, Owen J|Ryan, Kevin M
PMID: 24305049
Journal: Neoplasia. 2013 Dec;15(12):1354-62.
Title: Synthetic lethality screen identifies RPS6KA2 as modifier of epidermal growth factor receptor activity in pancreatic cancer.
Author: Milosevic, Nada|Kuhnemuth, Benjamin|Muhlberg, Leonie|Ripka, Stefanie|Griesmann, Heidi|Lolkes, Carolin|Buchholz, Malte|Aust, Daniela|Pilarsky, Christian|Krug, Sebastian|Gress, Thomas|Michl, Patrick
PMID: 24403857
Journal: Front Physiol. 2014 Jan 16;4:415.
Title: Risk factors for pancreatic cancer: underlying mechanisms and potential targets.
Author: Kolodecik, Thomas|Shugrue, Christine|Ashat, Munish|Thrower, Edwin C
PMID: 24474939
Journal: Front Physiol. 2014 Jan 21;4:407.
Title: Kras as a key oncogene and therapeutic target in pancreatic cancer.
Author: Collins, Meredith A|Pasca di Magliano, Marina
PMID: 24478710
Journal: Bio Protoc. 2013 Oct 5;3(19).
Title: Pancreatic Acinar Cell 3-Dimensional Culture.
Author: Qu, Chunjing|Konieczny, Stephen F
PMID: 27453905
Journal: Oncogene. 2014 Feb 13;33(7):823-31.
Title: Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia.
Author: Ray, K C|Moss, M E|Franklin, J L|Weaver, C J|Higginbotham, J|Song, Y|Revetta, F L|Blaine, S A|Bridges, L R|Guess, K E|Coffey, R J|Crawford, H C|Washington, M K|Means, A L
PMID: 23376846
Journal: Oncogene. 2014 Mar 13;33(11):1367-74.
Title: Pancreatic tumours escape from translational control through 4E-BP1 loss.
Author: Martineau, Y|Azar, R|Muller, D|Lasfargues, C|El Khawand, S|Anesia, R|Pelletier, J|Bousquet, C|Pyronnet, S
PMID: 23563181
Journal: Gut. 2014 Apr;63(4):647-55.
Title: Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas(G12V)-driven pancreatic tumourigenesis.
Author: Flandez, Marta|Cendrowski, Jaroslaw|Canamero, Marta|Salas, Antonio|del Pozo, Natalia|Schoonjans, Kristina|Real, Francisco X
PMID: 23598351
Journal: Gut. 2014 Apr;63(4):656-64.
Title: Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation.
Author: von Figura, Guido|Morris, John P 4th|Wright, Christopher V E|Hebrok, Matthias
PMID: 23645620
Journal: Oncogene. 2014 May 8;33(19):2454-63.
Title: EVI1 oncogene promotes KRAS pathway through suppression of microRNA-96 in pancreatic carcinogenesis.
Author: Tanaka, M|Suzuki, H I|Shibahara, J|Kunita, A|Isagawa, T|Yoshimi, A|Kurokawa, M|Miyazono, K|Aburatani, H|Ishikawa, S|Fukayama, M
PMID: 23752186
Journal: Mod Pathol. 2014 Feb;27(2):262-70.
Title: KRAS mutational analysis and immunohistochemical studies can help distinguish pancreatic metastases from primary lung adenocarcinomas.
Author: Krasinskas, Alyssa M|Chiosea, Simon I|Pal, Timothy|Dacic, Sanja
PMID: 23887294
Journal: Surg Today. 2014 Jul;44(7):1313-20.
Title: Pancreatic cancer in the remnant pancreas following primary pancreatic resection.
Author: Hashimoto, Daisuke|Chikamoto, Akira|Ohmuraya, Masaki|Sakata, Kazuya|Miyake, Keisuke|Kuroki, Hideyuki|Watanabe, Masayuki|Beppu, Toru|Hirota, Masahiko|Baba, Hideo
PMID: 23975591
Journal: Gastroenterology. 2014 Jan;146(1):233-44.e5.
Title: Identification and manipulation of biliary metaplasia in pancreatic tumors.
Author: Delgiorno, Kathleen E|Hall, Jason C|Takeuchi, Kenneth K|Pan, Fong Cheng|Halbrook, Christopher J|Washington, M Kay|Olive, Kenneth P|Spence, Jason R|Sipos, Bence|Wright, Christopher V E|Wells, James M|Crawford, Howard C
PMID: 23999170
Journal: Gut. 2014 Jun;63(6):984-95.
Title: Genetic inactivation of Nupr1 acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis.
Author: Cano, Carla E|Hamidi, Tewfik|Garcia, Maria Noe|Grasso, Daniel|Loncle, Celine|Garcia, Stephane|Calvo, Ezequiel|Lomberk, Gwen|Dusetti, Nelson|Bartholin, Laurent|Urrutia, Raul|Iovanna, Juan L
PMID: 24026351
Journal: Nanomedicine. 2014 Feb;10(2):463-72.
Title: Combination of siRNA-directed Kras oncogene silencing and arsenic-induced apoptosis using a nanomedicine strategy for the effective treatment of pancreatic cancer.
Author: Zeng, Linjuan|Li, Jingguo|Wang, Yong|Qian, Chenchen|Chen, Yinting|Zhang, Qiubo|Wu, Wei|Lin, Zhong|Liang, Jianzhong|Shuai, Xintao|Huang, Kaihong
PMID: 24028894
Journal: Gut. 2014 Jun;63(6):974-83.
Title: SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice.
Author: Neesse, Albrecht|Frese, Kristopher K|Chan, Derek S|Bapiro, Tashinga E|Howat, William J|Richards, Frances M|Ellenrieder, Volker|Jodrell, Duncan I|Tuveson, David A
PMID: 24067278
Journal: Gastroenterology. 2014 Jan;146(1):257-67.
Title: Activated wnt signaling in stroma contributes to development of pancreatic mucinous cystic neoplasms.
Author: Sano, Makoto|Driscoll, David R|De Jesus-Monge, Wilfredo E|Klimstra, David S|Lewis, Brian C
PMID: 24067880
Journal: Am J Physiol Gastrointest Liver Physiol. 2014 Jan;306(2):G91-G101.
Title: Cholecystokinin and pancreatic cancer: the chicken or the egg?
Author: Smith, Jill P|Solomon, Travis E
PMID: 24177032
Journal: Toxicol Pathol. 2014 Jan;42(1):217-28.
Title: Pathogenesis of pancreatic cancer: lessons from animal models.
Author: Murtaugh, L Charles
PMID: 24178582
Journal: Dig Liver Dis. 2014 Feb;46(2):182-6.
Title: Sorafenib does not improve efficacy of chemotherapy in advanced pancreatic cancer: A GISCAD randomized phase II study.
Author: Cascinu, Stefano|Berardi, Rossana|Sobrero, Alberto|Bidoli, Paolo|Labianca, Roberto|Siena, Salvatore|Ferrari, Daris|Barni, Sandro|Aitini, Enrico|Zagonel, Vittorina|Caprioni, Francesco|Villa, Federica|Mosconi, Stefania|Faloppi, Luca|Tonini, Giuseppe|Boni, C
PMID: 24189171
Journal: Mol Cancer Ther. 2014 Jan;13(1):122-33.
Title: Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation.
Author: Neel, Nicole F|Stratford, Jeran K|Shinde, Vaishali|Ecsedy, Jeffrey A|Martin, Timothy D|Der, Channing J|Yeh, Jen Jen
PMID: 24222664
Journal: Oncogene. 2014 Nov 20;33(47):5405-14.
Title: Preclinical validation of AXL receptor as a target for antibody-based pancreatic cancer immunotherapy.
Author: Leconet, W|Larbouret, C|Chardes, T|Thomas, G|Neiveyans, M|Busson, M|Jarlier, M|Radosevic-Robin, N|Pugniere, M|Bernex, F|Penault-Llorca, F|Pasquet, J-M|Pelegrin, A|Robert, B
PMID: 24240689
Journal: Gastroenterology. 2014 Mar;146(3):822-834.e7.
Title: MAPK signaling is required for dedifferentiation of acinar cells and development of pancreatic intraepithelial neoplasia in mice.
Author: Collins, Meredith A|Yan, Wei|Sebolt-Leopold, Judith S|Pasca di Magliano, Marina
PMID: 24315826
Journal: Pancreas. 2014 Jan;43(1):150-2.
Title: Translational research in pancreatic cancer: KRAS and beyond.
Author: Boeck, Stefan|Ormanns, Steffen|Haas, Michael|Bachmann, Sibylle|Laubender, Rudiger P|Siveke, Jens T|Jung, Andreas|Kirchner, Thomas|Heinemann, Volker
PMID: 24326376
Journal: Cancer Res. 2014 Feb 15;74(4):1190-9.
Title: Phosphorylation at Ser-181 of oncogenic KRAS is required for tumor growth.
Author: Barcelo, Carles|Paco, Noelia|Morell, Mireia|Alvarez-Moya, Blanca|Bota-Rabassedas, Neus|Jaumot, Montserrat|Vilardell, Felip|Capella, Gabriel|Agell, Neus
PMID: 24371225
Journal: Trends Biochem Sci. 2014 Feb;39(2):91-100.
Title: KRAS: feeding pancreatic cancer proliferation.
Author: Bryant, Kirsten L|Mancias, Joseph D|Kimmelman, Alec C|Der, Channing J
PMID: 24388967
Journal: Front Biosci (Landmark Ed). 2014 Jan 1;19:113-25.
Title: Embelin suppresses pancreatic cancer growth by modulating tumor immune microenvironment.
Author: Marsh, Justine L|Jackman, Chris P|Tang, Su-Ni|Shankar, Sharmila|Srivastava, Rakesh K
PMID: 24389175
Journal: Genes Dev. 2014 Jan 1;28(1):85-97.
Title: A modular and flexible ESC-based mouse model of pancreatic cancer.
Author: Saborowski, Michael|Saborowski, Anna|Morris, John P 4th|Bosbach, Benedikt|Dow, Lukas E|Pelletier, Jerry|Klimstra, David S|Lowe, Scott W
PMID: 24395249
Journal: J Biol Chem. 2014 Feb 14;289(7):3869-75.
Title: Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer.
Author: Kahlert, Christoph|Melo, Sonia A|Protopopov, Alexei|Tang, Jiabin|Seth, Sahil|Koch, Moritz|Zhang, Jianhua|Weitz, Juergen|Chin, Lynda|Futreal, Andrew|Kalluri, Raghu
PMID: 24398677
Journal: Am J Clin Pathol. 2014 Feb;141(2):168-80.
Title: Molecular genetics of pancreatic neoplasms and their morphologic correlates: an update on recent advances and potential diagnostic applications.
Author: Reid, Michelle D|Saka, Burcu|Balci, Serdar|Goldblum, Andrew S|Adsay, N Volkan
PMID: 24436263
Journal: Diagn Pathol. 2014 Jan 20;9:11.
Title: Case report: Intraductal tubulopapillary neoplasm of the pancreas with unique clear cell phenotype.
Author: Ahls, Maria Gabriele|Niedergethmann, Marco|Dinter, Dietmar|Sauer, Christian|Luttges, Jutta|Post, Stefan|Marx, Alexander|Gaiser, Timo
PMID: 24443801
Journal: Cancer J. 2014 Jan-Feb;20(1):80-4.
Title: Genetic progression of pancreatic cancer.
Author: Cowan, Robert W|Maitra, Anirban
PMID: 24445769
Journal: Gastroenterology. 2014 May;146(5):1386-96.e1-17.
Title: Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes.
Author: Li, Ang|Morton, Jennifer P|Ma, YaFeng|Karim, Saadia A|Zhou, Yan|Faller, William J|Woodham, Emma F|Morris, Hayley T|Stevenson, Richard P|Juin, Amelie|Jamieson, Nigel B|MacKay, Colin J|Carter, C Ross|Leung, Hing Y|Yamashiro, Shigeko|Blyth, Karen|Sansom, Owe
PMID: 24462734
Journal: Pathol Int. 2014 Jan;64(1):10-9.
Title: Molecular pathology of pancreatic cancer.
Author: Saiki, Yuriko|Horii, Akira
PMID: 24471965
Journal: Genome Med. 2014 Jan 31;6(1):9.
Title: STAG2 is a clinically relevant tumor suppressor in pancreatic ductal adenocarcinoma.
Author: Evers, Lisa|Perez-Mancera, Pedro A|Lenkiewicz, Elizabeth|Tang, Nanyun|Aust, Daniela|Knosel, Thomas|Rummele, Petra|Holley, Tara|Kassner, Michelle|Aziz, Meraj|Ramanathan, Ramesh K|Von Hoff, Daniel D|Yin, Holly|Pilarsky, Christian|Barrett, Michael T
PMID: 24484537
Journal: Cancer Lett. 2014 May 1;346(2):264-72.
Title: Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases.
Author: Yeo, Dannel|Huynh, Nhi|Beutler, John A|Christophi, Christopher|Shulkes, Arthur|Baldwin, Graham S|Nikfarjam, Mehrdad|He, Hong
PMID: 24491405
Journal: Pancreas. 2014 Mar;43(2):183-9.
Title: The RON receptor tyrosine kinase in pancreatic cancer pathogenesis and its potential implications for future targeted therapies.
Author: Kang, Chang Moo|Babicky, Michele L|Lowy, Andrew M
PMID: 24518495
Journal: Pancreas. 2014 Mar;43(2):245-9.
Title: PIK3CA mutations in mucinous cystic neoplasms of the pancreas.
Author: Garcia-Carracedo, Dario|Chen, Zong-Ming|Qiu, Wanglong|Huang, Alicia S|Tang, Sophia M|Hruban, Ralph H|Su, Gloria H
PMID: 24518503
Journal: J Nucl Med. 2014 Mar;55(3):446-51.
Title: Multimodal molecular imaging of integrin alphavbeta3 for in vivo detection of pancreatic cancer.
Author: Trajkovic-Arsic, Marija|Mohajerani, Pouyan|Sarantopoulos, Athanasios|Kalideris, Evdokia|Steiger, Katja|Esposito, Irene|Ma, Xiaopeng|Themelis, George|Burton, Neal|Michalski, Christoph W|Kleeff, Jorg|Stangl, Stefan|Beer, Ambros J|Pohle, Karolin|Wester, Hans
PMID: 24549287
Journal: Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3466-71.
Title: Analysis of the tumor-initiating and metastatic capacity of PDX1-positive cells from the adult pancreas.
Author: Ischenko, Irene|Petrenko, Oleksi|Hayman, Michael J
PMID: 24550494
Journal: Sci Transl Med. 2014 Feb 19;6(224):224ra24.
Title: Detection of circulating tumor DNA in early- and late-stage human malignancies.
Author: Bettegowda, Chetan|Sausen, Mark|Leary, Rebecca J|Kinde, Isaac|Wang, Yuxuan|Agrawal, Nishant|Bartlett, Bjarne R|Wang, Hao|Luber, Brandon|Alani, Rhoda M|Antonarakis, Emmanuel S|Azad, Nilofer S|Bardelli, Alberto|Brem, Henry|Cameron, John L|Lee, Clarence C|Fe
PMID: 24553385
Journal: Mol Cancer. 2014 Feb 25;13:38.
Title: Targeting the prohibitin scaffold-CRAF kinase interaction in RAS-ERK-driven pancreatic ductal adenocarcinoma.
Author: Luan, Zhou|He, Ying|Alattar, Mohamed|Chen, Zhishui|He, Fan
PMID: 24568222
Journal: J Pathol. 2014 Jul;233(3):217-27.
Title: Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas.
Author: Amato, Eliana|Molin, Marco Dal|Mafficini, Andrea|Yu, Jun|Malleo, Giuseppe|Rusev, Borislav|Fassan, Matteo|Antonello, Davide|Sadakari, Yoshihiko|Castelli, Paola|Zamboni, Giuseppe|Maitra, Anirban|Salvia, Roberto|Hruban, Ralph H|Bassi, Claudio|Capelli, Paola|
PMID: 24604757
Journal: JOP. 2014 Mar 10;15(2):114-7.
Title: Pharmacogenomics update in pancreatic cancer.
Author: Puri, Aditi|Saif, Muhammad Wasif
PMID: 24618431
Journal: J Cell Physiol. 2014 Oct;229(10):1437-43.
Title: Pancreatic cancer-induced cachexia is Jak2-dependent in mice.
Author: Gilabert, Marine|Calvo, Ezequiel|Airoldi, Ana|Hamidi, Tewfik|Moutardier, Vincent|Turrini, Olivier|Iovanna, Juan
PMID: 24648112
Journal: Cancer Res. 2014 Apr 15;74(8):2138-43.
Title: Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: a lingering challenge in the development of targeted therapies.
Author: Lin, Wan-Chi|Rajbhandari, Nirakar|Wagner, Kay-Uwe
PMID: 24670819
Journal: Pancreas. 2014 May;43(4):578-83.
Title: KRAS mutations in codon 12 or 13 are associated with worse prognosis in pancreatic ductal adenocarcinoma.
Author: Sinn, Bruno V|Striefler, Jana K|Rudl, Marc A|Lehmann, Annika|Bahra, Marcus|Denkert, Carsten|Sinn, Marianne|Stieler, Jens|Klauschen, Frederick|Budczies, Jan|Weichert, Wilko|Stenzinger, Albrecht|Kamphues, Carsten|Dietel, Manfred|Riess, Hanno
PMID: 24681874
Journal: Lab Chip. 2014 May 21;14(10):1775-84.
Title: Microfluidic immunocapture of circulating pancreatic cells using parallel EpCAM and MUC1 capture: characterization, optimization and downstream analysis.
Author: Thege, Fredrik I|Lannin, Timothy B|Saha, Trisha N|Tsai, Shannon|Kochman, Michael L|Hollingsworth, Michael A|Rhim, Andrew D|Kirby, Brian J
PMID: 24681997
Journal: J Clin Invest. 2014 May;124(5):2125-35. Epub 2014 Apr 1.
Title: Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression.
Author: Rielland, Maite|Cantor, David J|Graveline, Richard|Hajdu, Cristina|Mara, Lisa|Diaz, Beatriz de Diego|Miller, George|David, Gregory
PMID: 24691445
Journal: Cancer Discov. 2014 Jun;4(6):688-701.
Title: Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.
Author: Baumgart, Sandra|Chen, Nai-Ming|Siveke, Jens T|Konig, Alexander|Zhang, Jin-San|Singh, Shiv K|Wolf, Elmar|Bartkuhn, Marek|Esposito, Irene|Hessmann, Elisabeth|Reinecke, Johanna|Nikorowitsch, Julius|Brunner, Marius|Singh, Garima|Fernandez-Zapico, Martin E|Sm
PMID: 24694735
Journal: Cancer Res. 2014 Jun 15;74(12):3344-56.
Title: Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma.
Author: Davies, Clare C|Harvey, Emma|McMahon, Raymond F T|Finegan, Katherine G|Connor, Frances|Davis, Roger J|Tuveson, David A|Tournier, Cathy
PMID: 24713432
Journal: Gut. 2014 Sep;63(9):1481-9.
Title: Targeting mTOR dependency in pancreatic cancer.
Author: Morran, Douglas C|Wu, Jianmin|Jamieson, Nigel B|Mrowinska, Agata|Kalna, Gabriela|Karim, Saadia A|Au, Amy Y M|Scarlett, Christopher J|Chang, David K|Pajak, Malgorzata Z|Oien, Karin A|McKay, Colin J|Carter, C Ross|Gillen, Gerry|Champion, Sue|Pimlott, Sally
PMID: 24717934
Journal: Cell Death Dis. 2014 Apr 10;5:e1160.
Title: Resistance to the tyrosine kinase inhibitor axitinib is associated with increased glucose metabolism in pancreatic adenocarcinoma.
Author: Hudson, C D|Hagemann, T|Mather, S J|Avril, N
PMID: 24722285
Journal: Exp Cell Res. 2014 Jun 10;324(2):157-71.
Title: SULF1/SULF2 splice variants differentially regulate pancreatic tumour growth progression.
Author: Gill, Roop M S|Michael, Andreas|Westley, Leah|Kocher, Hemant M|Murphy, Joshua I|Dhoot, Gurtej K
PMID: 24726914
Journal: J Biol Chem. 2014 Jun 6;289(23):16516-25.
Title: Inactivation of the transcription factor GLI1 accelerates pancreatic cancer progression.
Author: Mills, Lisa D|Zhang, Lizhi|Marler, Ronald|Svingen, Phyllis|Fernandez-Barrena, Maite G|Dave, Maneesh|Bamlet, William|McWilliams, Robert R|Petersen, Gloria M|Faubion, William|Fernandez-Zapico, Martin E
PMID: 24737325
Journal: Carcinogenesis. 2014 Jul;35(7):1441-50.
Title: The complex landscape of pancreatic cancer metabolism.
Author: Sousa, Cristovao Marques|Kimmelman, Alec C
PMID: 24743516
Journal: Nat Cell Biol. 2014 May;16(5):457-68.
Title: An integrin beta(3)-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.
Author: Seguin, Laetitia|Kato, Shumei|Franovic, Aleksandra|Camargo, M Fernanda|Lesperance, Jacqueline|Elliott, Kathryn C|Yebra, Mayra|Mielgo, Ainhoa|Lowy, Andrew M|Husain, Hatim|Cascone, Tina|Diao, Lixia|Wang, Jing|Wistuba, Ignacio I|Heymach, John V|Lippman, Scot
PMID: 24747441
Journal: Mol Cancer Res. 2014 Jul;12(7):1055-66.
Title: Evaluating TBK1 as a therapeutic target in cancers with activated IRF3.
Author: Muvaffak, Asli|Pan, Qi|Yan, Haiyan|Fernandez, Rafael|Lim, Jongwon|Dolinski, Brian|Nguyen, Thi T|Strack, Peter|Wu, Stephen|Chung, Rossana|Zhang, Weiqun|Hulton, Chris|Ripley, Steven|Hirsch, Heather|Nagashima, Kumiko|Wong, Kwok-Kin|Janne, Pasi A|Seidel-Dugan
PMID: 24752990
Journal: Br J Cancer. 2014 Aug 26;111(5):817-22.
Title: Oncogenic KRAS signalling in pancreatic cancer.
Author: Eser, S|Schnieke, A|Schneider, G|Saur, D
PMID: 24755884
Journal: PLoS One. 2014 May 1;9(5):e95486.
Title: Dicer regulates differentiation and viability during mouse pancreatic cancer initiation.
Author: Morris, John P 4th|Greer, Renee|Russ, Holger A|von Figura, Guido|Kim, Grace E|Busch, Anke|Lee, Jonghyeob|Hertel, Klemens J|Kim, Seung|McManus, Michael|Hebrok, Matthias
PMID: 24788257
Journal: Cancer Immunol Res. 2014 May;2(5):423-35.
Title: CD4+ T lymphocyte ablation prevents pancreatic carcinogenesis in mice.
Author: Zhang, Yaqing|Yan, Wei|Mathew, Esha|Bednar, Filip|Wan, Shanshan|Collins, Meredith A|Evans, Rebecca A|Welling, Theodore H|Vonderheide, Robert H|di Magliano, Marina Pasca
PMID: 24795355
Journal: Biotechnol J. 2014 May;9(5):652-63.
Title: Knockdown of ribosomal protein L39 by RNA interference inhibits the growth of human pancreatic cancer cells in vitro and in vivo.
Author: Li, Chaodong|Chen, Daijie|Luo, Minyu|Ge, Mei|Zhu, Jianwei
PMID: 24799381
Journal: Cancer Cell. 2014 May 12;25(5):553-4.
Title: Tumor-promoting inflammatory networks in pancreatic neoplasia: another reason to loathe Kras.
Author: Vonderheide, Robert H
PMID: 24823632
Journal: Ann Oncol. 2014 Jul;25(7):1384-90.
Title: Phase II, randomized, biomarker identification trial (MARK) for erlotinib in patients with advanced pancreatic carcinoma.
Author: Propper, D|Davidenko, I|Bridgewater, J|Kupcinskas, L|Fittipaldo, A|Hillenbach, C|Klughammer, B|Ducreux, M
PMID: 24827134
Journal: Mol Cancer Res. 2014 Oct;12(10):1430-9.
Title: Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma.
Author: Mehner, Christine|Miller, Erin|Khauv, Davitte|Nassar, Aziza|Oberg, Ann L|Bamlet, William R|Zhang, Lizhi|Waldmann, Jens|Radisky, Evette S|Crawford, Howard C|Radisky, Derek C
PMID: 24850902
Journal: Eur J Cancer. 2014 Jul;50(11):1909-15.
Title: A phase II study of erlotinib in gemcitabine refractory advanced pancreatic cancer.
Author: Renouf, D J|Tang, P A|Hedley, D|Chen, E|Kamel-Reid, S|Tsao, M S|Tran-Thanh, D|Gill, S|Dhani, N|Au, H J|Wang, L|Moore, M J
PMID: 24857345
Journal: Br J Cancer. 2014 Jul 15;111(2):318-25.
Title: Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo.
Author: Bapiro, T E|Frese, K K|Courtin, A|Bramhall, J L|Madhu, B|Cook, N|Neesse, A|Griffiths, J R|Tuveson, D A|Jodrell, D I|Richards, F M
PMID: 24874484
Journal: Cancer Discov. 2014 Aug;4(8):905-13.
Title: Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations.
Author: Yang, Annan|Rajeshkumar, N V|Wang, Xiaoxu|Yabuuchi, Shinichi|Alexander, Brian M|Chu, Gerald C|Von Hoff, Daniel D|Maitra, Anirban|Kimmelman, Alec C
PMID: 24875860
Journal: Dis Model Mech. 2014 Jul;7(7):883-94.
Title: Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer.
Author: Schiavone, Marco|Rampazzo, Elena|Casari, Alessandro|Battilana, Giusy|Persano, Luca|Moro, Enrico|Liu, Shu|Leach, Steve D|Tiso, Natascia|Argenton, Francesco
PMID: 24878567
Journal: Cancer Lett. 2014 Aug 28;351(1):151-61.
Title: XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism.
Author: Sureban, Sripathi M|May, Randal|Weygant, Nathaniel|Qu, Dongfeng|Chandrakesan, Parthasarathy|Bannerman-Menson, Eddie|Ali, Naushad|Pantazis, Panayotis|Westphalen, Christoph B|Wang, Timothy C|Houchen, Courtney W
PMID: 24880079
Journal: Cell Death Differ. 2014 Oct;21(10):1633-41.
Title: Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras(G12D)-induced senescence.
Author: Grasso, D|Garcia, M N|Hamidi, T|Cano, C|Calvo, E|Lomberk, G|Urrutia, R|Iovanna, J L
PMID: 24902898
Journal: Eur J Cancer. 2014 Aug;50(12):2072-81.
Title: A randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas.
Author: Infante, Jeffrey R|Somer, Bradley G|Park, Joon Oh|Li, Chung-Pin|Scheulen, Max E|Kasubhai, Saifuddin M|Oh, Do-Youn|Liu, Yuan|Redhu, Suman|Steplewski, Klaudia|Le, Ngocdiep
PMID: 24915778
Journal: Carcinogenesis. 2014 Nov;35(11):2404-14.
Title: Loss of histone demethylase KDM6B enhances aggressiveness of pancreatic cancer through downregulation of C/EBPalpha.
Author: Yamamoto, Keisuke|Tateishi, Keisuke|Kudo, Yotaro|Sato, Tomohiko|Yamamoto, Shinzo|Miyabayashi, Koji|Matsusaka, Keisuke|Asaoka, Yoshinari|Ijichi, Hideaki|Hirata, Yoshihiro|Otsuka, Motoyuki|Nakai, Yousuke|Isayama, Hiroyuki|Ikenoue, Tsuneo|Kurokawa, Mineo|Fuk
PMID: 24947179
Journal: Neoplasia. 2014 Jun;16(6):463-70.
Title: Chronic pancreatitis and systemic inflammatory response syndrome prevent impact of chemotherapy with gemcitabine in a genetically engineered mouse model of pancreatic cancer.
Author: Knoop, Richard F|Sparn, Moritz|Waldmann, Jens|Plassmeier, Lars|Bartsch, Detlef K|Lauth, Matthias|Hudemann, Christoph|Fendrich, Volker
PMID: 24953430
Journal: Cell. 2014 Jul 3;158(1):185-97.
Title: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer.
Author: Kapoor, Avnish|Yao, Wantong|Ying, Haoqiang|Hua, Sujun|Liewen, Alison|Wang, Qiuyun|Zhong, Yi|Wu, Chang-Jiun|Sadanandam, Anguraj|Hu, Baoli|Chang, Qing|Chu, Gerald C|Al-Khalil, Ramsey|Jiang, Shan|Xia, Hongai|Fletcher-Sananikone, Eliot|Lim, Carol|Horwitz, Gil
PMID: 24954535
Journal: PLoS One. 2014 Jun 30;9(6):e100880.
Title: Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor.
Author: Dumble, Melissa|Crouthamel, Ming-Chih|Zhang, Shu-Yun|Schaber, Michael|Levy, Dana|Robell, Kimberly|Liu, Qi|Figueroa, David J|Minthorn, Elisabeth A|Seefeld, Mark A|Rouse, Meagan B|Rabindran, Sridhar K|Heerding, Dirk A|Kumar, Rakesh
PMID: 24978597
Journal: Gastroenterology. 2014 Oct;147(4):882-892.e8.
Title: Ribonucleoprotein HNRNPA2B1 interacts with and regulates oncogenic KRAS in pancreatic ductal adenocarcinoma cells.
Author: Barcelo, Carles|Etchin, Julia|Mansour, Marc R|Sanda, Takaomi|Ginesta, Mireia M|Sanchez-Arevalo Lobo, Victor J|Real, Francisco X|Capella, Gabriel|Estanyol, Josep M|Jaumot, Montserrat|Look, A Thomas|Agell, Neus
PMID: 24998203
Journal: Br J Cancer. 2014 Jul 29;111(3):486-96.
Title: Novel role of pancreatic differentiation 2 in facilitating self-renewal and drug resistance of pancreatic cancer stem cells.
Author: Vaz, A P|Ponnusamy, M P|Rachagani, S|Dey, P|Ganti, A K|Batra, S K
PMID: 25003666
Journal: Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3091-100.
Title: Stromal response to Hedgehog signaling restrains pancreatic cancer progression.
Author: Lee, John J|Perera, Rushika M|Wang, Huaijun|Wu, Dai-Chen|Liu, X Shawn|Han, Shiwei|Fitamant, Julien|Jones, Phillip D|Ghanta, Krishna S|Kawano, Sally|Nagle, Julia M|Deshpande, Vikram|Boucher, Yves|Kato, Tomoyo|Chen, James K|Willmann, Jurgen K|Bardeesy, Nabe
PMID: 25024225
Journal: J Pathol. 2014 Oct;234(2):228-38.
Title: A genetically engineered mouse model developing rapid progressive pancreatic ductal adenocarcinoma.
Author: Yamaguchi, Takashi|Ikehara, Sanae|Nakanishi, Hayao|Ikehara, Yuzuru
PMID: 25042889
Journal: Cancer Lett. 2014 Oct 10;353(1):32-40.
Title: Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice.
Author: Huang, Minzhao|Tang, Su-Ni|Upadhyay, Ghanshyam|Marsh, Justin L|Jackman, Christopher P|Srivastava, Rakesh K|Shankar, Sharmila
PMID: 25050737
Journal: Pancreas. 2014 Oct;43(7):1050-9.
Title: Cholecystokinin receptor antagonist halts progression of pancreatic cancer precursor lesions and fibrosis in mice.
Author: Smith, Jill P|Cooper, Timothy K|McGovern, Christopher O|Gilius, Evan L|Zhong, Qing|Liao, Jiangang|Molinolo, Alfredo A|Gutkind, J Silvio|Matters, Gail L
PMID: 25058882
Journal: JOP. 2014 Jul 28;15(4):303-5.
Title: KRAS in pancreatic cancer.
Author: Agarwal, Archana|Saif, Muhammad Wasif
PMID: 25076326
Journal: Hepatobiliary Pancreat Dis Int. 2014 Aug;13(4):371-80.
Title: Interleukin-6: a villain in the drama of pancreatic cancer development and progression.
Author: Holmer, Reinhild|Goumas, Freya A|Waetzig, Georg H|Rose-John, Stefan|Kalthoff, Holger
PMID: 25100121
Journal: J Biol Chem. 2014 Oct 3;289(40):27727-43.
Title: The transcription factor GLI1 modulates the inflammatory response during pancreatic tissue remodeling.
Author: Mathew, Esha|Collins, Meredith A|Fernandez-Barrena, Maite G|Holtz, Alexander M|Yan, Wei|Hogan, James O|Tata, Zachary|Allen, Benjamin L|Fernandez-Zapico, Martin E|di Magliano, Marina Pasca
PMID: 25104358
Journal: Chemosphere. 2014 Nov;114:219-25.
Title: Adjusting serum concentrations of organochlorine compounds by lipids and symptoms: a causal framework for the association with K-ras mutations in pancreatic cancer.
Author: Lopez, Tomas|Pumarega, Jose A|Pollack, Anna Z|Lee, Duk-Hee|Richiardi, Lorenzo|Jacobs, David R Jr|Schisterman, Enrique F|Porta, Miquel
PMID: 25113205
Journal: Neoplasia. 2014 Jul;16(7):562-71.
Title: Co-treatment with panitumumab and trastuzumab augments response to the MEK inhibitor trametinib in a patient-derived xenograft model of pancreatic cancer.
Author: Lindberg, James M|Newhook, Timothy E|Adair, Sara J|Walters, Dustin M|Kim, Alison J|Stelow, Edward B|Parsons, J Thomas|Bauer, Todd W
PMID: 25117978
Journal: Nature. 2014 Oct 30;514(7524):628-32.
Title: Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.
Author: Viale, Andrea|Pettazzoni, Piergiorgio|Lyssiotis, Costas A|Ying, Haoqiang|Sanchez, Nora|Marchesini, Matteo|Carugo, Alessandro|Green, Tessa|Seth, Sahil|Giuliani, Virginia|Kost-Alimova, Maria|Muller, Florian|Colla, Simona|Nezi, Luigi|Genovese, Giannicola|Dee
PMID: 25119024
Journal: Gastroenterology. 2014 Nov;147(5):1119-33.e4.
Title: Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.
Author: Hermann, Patrick C|Sancho, Patricia|Canamero, Marta|Martinelli, Paola|Madriles, Francesc|Michl, Patrick|Gress, Thomas|de Pascual, Ricardo|Gandia, Luis|Guerra, Carmen|Barbacid, Mariano|Wagner, Martin|Vieira, Catarina R|Aicher, Alexandra|Real, Francisco X|S
PMID: 25127677
Journal: World J Gastroenterol. 2014 Aug 21;20(31):10752-7.
Title: Emerging role of the KRAS-PDK1 axis in pancreatic cancer.
Author: Ferro, Riccardo|Falasca, Marco
PMID: 25152578
Journal: World J Gastroenterol. 2014 Aug 21;20(31):10758-68.
Title: Role of endoscopic ultrasound in the molecular diagnosis of pancreatic cancer.
Author: Bournet, Barbara|Gayral, Marion|Torrisani, Jerome|Selves, Janick|Cordelier, Pierre|Buscail, Louis
PMID: 25152579
Journal: World J Gastroenterol. 2014 Aug 21;20(31):10825-44.
Title: Novel therapeutic targets for pancreatic cancer.
Author: Tang, Shing-Chun|Chen, Yang-Chao
PMID: 25152585
Journal: Br J Cancer. 2014 Oct 28;111(9):1788-801.
Title: KRAS mutational subtype and copy number predict in vitro response of human pancreatic cancer cell lines to MEK inhibition.
Author: Hamidi, H|Lu, M|Chau, K|Anderson, L|Fejzo, M|Ginther, C|Linnartz, R|Zubel, A|Slamon, D J|Finn, R S
PMID: 25167228
Journal: Gastroenterology. 2014 Oct;147(4):736-9.
Title: The increasing diversity of KRAS signaling in pancreatic cancer.
Author: Siveke, Jens T
PMID: 25167989
Journal: NMR Biomed. 2014 Nov;27(11):1361-70.
Title: HR-MAS MRS of the pancreas reveals reduced lipid and elevated lactate and taurine associated with early pancreatic cancer.
Author: Wang, Alan S|Lodi, Alessia|Rivera, Lee B|Izquierdo-Garcia, Jose L|Firpo, Matthew A|Mulvihill, Sean J|Tempero, Margaret A|Bergers, Gabriele|Ronen, Sabrina M
PMID: 25199993
Journal: Sci China Life Sci. 2014 Oct;57(10):1011-7.
Title: Recombinant expression of different mutant K-ras gene in pancreatic cancer Bxpc-3 cells and its effects on chemotherapy sensitivity.
Author: Shao, TengFei|Zheng, YuanTing|Zhao, Bei|Li, Tao|Cheng, KeGuang|Cai, WeiMin
PMID: 25216706
Journal: Cancer Prev Res (Phila). 2014 Dec;7(12):1198-209.
Title: Eflornithine (DFMO) prevents progression of pancreatic cancer by modulating ornithine decarboxylase signaling.
Author: Mohammed, Altaf|Janakiram, Naveena B|Madka, Venkateshwar|Ritchie, Rebekah L|Brewer, Misty|Biddick, Laura|Patlolla, Jagan Mohan R|Sadeghi, Michael|Lightfoot, Stan|Steele, Vernon E|Rao, Chinthalapally V
PMID: 25248858
Journal: J Clin Invest. 2014 Nov;124(11):4709-22.
Title: IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation.
Author: Garcia, Maria Noe|Grasso, Daniel|Lopez-Millan, Maria Belen|Hamidi, Tewfik|Loncle, Celine|Tomasini, Richard|Lomberk, Gwen|Porteu, Francoise|Urrutia, Raul|Iovanna, Juan L
PMID: 25250570
Journal: Cancer Res. 2014 Nov 15;74(22):6671-81.
Title: A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer.
Author: Fujimura, Ken|Wright, Tracy|Strnadel, Jan|Kaushal, Sharmeela|Metildi, Cristina|Lowy, Andrew M|Bouvet, Michael|Kelber, Jonathan A|Klemke, Richard L
PMID: 25261239
Journal: Nat Med. 2014 Oct;20(10):1193-1198.
Title: Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development.
Author: Mayers, Jared R|Wu, Chen|Clish, Clary B|Kraft, Peter|Torrence, Margaret E|Fiske, Brian P|Yuan, Chen|Bao, Ying|Townsend, Mary K|Tworoger, Shelley S|Davidson, Shawn M|Papagiannakopoulos, Thales|Yang, Annan|Dayton, Talya L|Ogino, Shuji|Stampfer, Meir J|Giova
PMID: 25261994
Journal: Semin Diagn Pathol. 2014 Nov;31(6):452-66.
Title: Intraductal neoplasms of the pancreas.
Author: Kloppel, Gunter|Basturk, Olca|Schlitter, Anna Melissa|Konukiewitz, Bjorn|Esposito, Irene
PMID: 25282472
Journal: Cancer Lett. 2014 Dec 28;355(2):273-80.
Title: Knockdown or inhibition of aldo-keto reductase 1B10 inhibits pancreatic carcinoma growth via modulating Kras-E-cadherin pathway.
Author: Zhang, Wanying|Li, Haonan|Yang, Yihe|Liao, Jie|Yang, Guang-Yu
PMID: 25304374
Journal: J Natl Cancer Inst. 2014 Oct 11;106(12). pii: dju320.
Title: Therapeutic effects of an anti-Myc drug on mouse pancreatic cancer.
Author: Stellas, Dimitris|Szabolcs, Matthias|Koul, Sanjay|Li, Zhe|Polyzos, Alexander|Anagnostopoulos, Constantinos|Cournia, Zoe|Tamvakopoulos, Constantin|Klinakis, Apostolos|Efstratiadis, Argiris
PMID: 25306215
Journal: World J Gastroenterol. 2014 Oct 7;20(37):13343-68.
Title: Gene therapy in pancreatic cancer.
Author: Liu, Si-Xue|Xia, Zhong-Sheng|Zhong, Ying-Qiang
PMID: 25309069
Journal: Gastroenterology. 2014 Dec;147(6):1405-16.e7.
Title: PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice.
Author: Wu, Chia-Yen C|Carpenter, Eileen S|Takeuchi, Kenneth K|Halbrook, Christopher J|Peverley, Louise V|Bien, Harold|Hall, Jason C|DelGiorno, Kathleen E|Pal, Debjani|Song, Yan|Shi, Chanjuan|Lin, Richard Z|Crawford, Howard C
PMID: 25311989
Journal: Cell Death Dis. 2014 Oct 23;5:e1480.
Title: RAGE is essential for oncogenic KRAS-mediated hypoxic signaling in pancreatic cancer.
Author: Kang, R|Hou, W|Zhang, Q|Chen, R|Lee, Y J|Bartlett, D L|Lotze, M T|Tang, D|Zeh, H J
PMID: 25341034
Journal: PLoS One. 2014 Oct 27;9(10):e111481.
Title: Rat N-ERC/mesothelin as a marker for in vivo screening of drugs against pancreas cancer.
Author: Fukamachi, Katsumi|Iigo, Masaaki|Hagiwara, Yoshiaki|Shibata, Koji|Futakuchi, Mitsuru|Alexander, David B|Hino, Okio|Suzui, Masumi|Tsuda, Hiroyuki
PMID: 25347530
Journal: Zebrafish. 2014 Dec;11(6):551-9.
Title: The tumor suppressor rpl36 restrains KRAS(G12V)-induced pancreatic cancer.
Author: Provost, Elayne|Bailey, Jennifer M|Aldrugh, Sumar|Liu, Shu|Iacobuzio-Donahue, Christine|Leach, Steven D
PMID: 25380065
Journal: Clin Transl Gastroenterol. 2014 Nov 13;5:e62.
Title: Mutant KRAS and GNAS DNA Concentrations in Secretin-Stimulated Pancreatic Fluid Collected from the Pancreatic Duct and the Duodenal Lumen.
Author: Sadakari, Yoshihiko|Kanda, Mitsuro|Maitani, Kosuke|Borges, Michael|Canto, Marcia I|Goggins, Michael
PMID: 25393586
Journal: BMC Cancer. 2014 Nov 22;14:862.
Title: Epithelial Notch signaling is a limiting step for pancreatic carcinogenesis.
Author: Thomas, Marsha M|Zhang, Yaqing|Mathew, Esha|Kane, Kevin T|Maillard, Ivan|Pasca di Magliano, Marina
PMID: 25416148
Journal: Int J Clin Exp Med. 2014 Oct 15;7(10):3225-34. eCollection 2014.
Title: Diagnostic value of combining CA 19-9 and K-ras gene mutation in pancreatic carcinoma: a meta-analysis.
Author: Gu, Jiangning|Wang, Di|Huang, Ya|Lu, Yi|Peng, Chenghong
PMID: 25419353
Journal: JOP. 2014 Nov 28;15(6):581-6.
Title: Differential expression of GNAS and KRAS mutations in pancreatic cysts.
Author: Lee, Linda S|Doyle, Leona A|Houghton, Jeffrey|Sah, Sachin|Bellizzi, Andrew M|Szafranska-Schwarzbach, Anna E|Conner, James R|Kadiyala, Vivek|Suleiman, Shadeah L|Banks, Peter A|Andruss, Bernard F|Conwell, Darwin L
PMID: 25435574
Journal: Semin Diagn Pathol. 2014 Nov;31(6):491-7.
Title: Pathology and genetics of pancreatic neoplasms with acinar differentiation.
Author: Wood, Laura D|Klimstra, David S
PMID: 25441307
Journal: Int J Biochem Cell Biol. 2014 Dec;57:142-8.
Title: Arrested development and the great escape--the role of cellular senescence in pancreatic cancer.
Author: Moir, John A G|White, Steven A|Mann, Jelena
PMID: 25461770
Journal: Oncotarget. 2014 Nov 30;5(22):10969-75.
Title: Critical role of NF-kappaB in pancreatic cancer.
Author: Prabhu, Lakshmi|Mundade, Rasika|Korc, Murray|Loehrer, Patrick J|Lu, Tao
PMID: 25473891
Journal: Cell Rep. 2014 Dec 24;9(6):2233-49.
Title: MCT4 defines a glycolytic subtype of pancreatic cancer with poor prognosis and unique metabolic dependencies.
Author: Baek, GuemHee|Tse, Yan F|Hu, Zeping|Cox, Derek|Buboltz, Noah|McCue, Peter|Yeo, Charles J|White, Michael A|DeBerardinis, Ralph J|Knudsen, Erik S|Witkiewicz, Agnieszka K
PMID: 25497091
Journal: Semin Diagn Pathol. 2014 Nov;31(6):484-90.
Title: Diagnosis and molecular aspects of solid-pseudopapillary neoplasms of the pancreas.
Author: Terris, Benoit|Cavard, Catherine
PMID: 25524568
Journal: Eksp Klin Gastroenterol. 2014;(10):70-6.
Title: [Genetic aspects of pancreatic cancer].
Author: Grigor'eva, I N|Efimova, O V|Suvorova, T S|Tov, N L
PMID: 25911935
Journal: Oncotarget. 2015 Mar 10;6(7):4553-61.
Title: Molecular landscape of pancreatic cancer: implications for current clinical trials.
Author: Heestand, Gregory M|Kurzrock, Razelle
PMID: 11051691
Journal: Oncogene. 2015 Jan 22;34(4):455-64.
Title: Transcriptional regulation of fibronectin by p21-activated kinase-1 modulates pancreatic tumorigenesis.
Author: Jagadeeshan, S|Krishnamoorthy, Y R|Singhal, M|Subramanian, A|Mavuluri, J|Lakshmi, A|Roshini, A|Baskar, G|Ravi, M|Joseph, L D|Sadasivan, K|Krishnan, A|Nair, A S|Venkatraman, G|Rayala, S K
PMID: 24561527
Journal: Oncogene. 2015 Feb 5;34(6):780-8.
Title: miR-219-1-3p is a negative regulator of the mucin MUC4 expression and is a tumor suppressor in pancreatic cancer.
Author: Lahdaoui, F|Delpu, Y|Vincent, A|Renaud, F|Messager, M|Duchene, B|Leteurtre, E|Mariette, C|Torrisani, J|Jonckheere, N|Van Seuningen, I
PMID: 24608432
Journal: Cancer Lett. 2015 Jan 28;356(2 Pt A):281-8.
Title: Epidemiological-molecular evidence of metabolic reprogramming on proliferation, autophagy and cell signaling in pancreas cancer.
Author: Soreide, Kjetil|Sund, Malin
PMID: 24704294
Journal: Leukemia. 2015 Jan;29(1):27-37.
Title: Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies.
Author: Weisberg, Ellen|Nonami, Atsushi|Chen, Zhao|Liu, Feiyang|Zhang, Jianming|Sattler, Martin|Nelson, Erik|Cowens, Kristen|Christie, Amanda L|Mitsiades, Constantine|Wong, Kwok-Kin|Liu, Qingsong|Gray, Nathanael|Griffin, James D
PMID: 24791855
Journal: J Clin Gastroenterol. 2015 Jan;49(1):50-6.
Title: Endoscopic ultrasound-guided fine-needle aspiration biopsy coupled with a KRAS mutation assay using allelic discrimination improves the diagnosis of pancreatic cancer.
Author: Bournet, Barbara|Selves, Janick|Grand, David|Danjoux, Marie|Hanoun, Naima|Cordelier, Pierre|Buscail, Louis
PMID: 24798941
Journal: Oncogene. 2015 May 21;34(21):2801-6.
Title: Differential in vivo tumorigenicity of diverse KRAS mutations in vertebrate pancreas: A comprehensive survey.
Author: Park, J T|Johnson, N|Liu, S|Levesque, M|Wang, Y J|Ho, H|Huso, D|Maitra, A|Parsons, M J|Prescott, J D|Leach, S D
PMID: 25065594
Journal: Mod Pathol. 2015 Feb;28(2):261-7.
Title: Clinicopathological significance of somatic RNF43 mutation and aberrant expression of ring finger protein 43 in intraductal papillary mucinous neoplasms of the pancreas.
Author: Sakamoto, Hitomi|Kuboki, Yuko|Hatori, Takashi|Yamamoto, Masakazu|Sugiyama, Masanori|Shibata, Noriyuki|Shimizu, Kyoko|Shiratori, Keiko|Furukawa, Toru
PMID: 25081753
Journal: Int J Clin Oncol. 2015 Jun;20(3):518-24.
Title: Pharmacodynamic separation of gemcitabine and erlotinib in locally advanced or metastatic pancreatic cancer: therapeutic and biomarker results.
Author: Semrad, Thomas|Barzi, Afsaneh|Lenz, Heinz-Josef|Hutchins, Irene M|Kim, Edward J|Gong, I-Yeh|Tanaka, Michael|Beckett, Laurel|Holland, William|Burich, Rebekah A|Snyder-Solis, Leslie|Mack, Philip|Lara, Primo N Jr
PMID: 25091263
Journal: Mod Pathol. 2015 Feb;28(2):248-60.
Title: Pancreatic undifferentiated rhabdoid carcinoma: KRAS alterations and SMARCB1 expression status define two subtypes.
Author: Agaimy, Abbas|Haller, Florian|Frohnauer, Judith|Schaefer, Inga-Marie|Strobel, Philipp|Hartmann, Arndt|Stoehr, Robert|Kloppel, Gunter
PMID: 25103069
Journal: J Gastroenterol. 2015 May;50(5):564-72.
Title: Does the WHO 2010 classification of pancreatic neuroendocrine neoplasms accurately characterize pancreatic neuroendocrine carcinomas?
Author: Hijioka, Susumu|Hosoda, Waki|Mizuno, Nobumasa|Hara, Kazuo|Imaoka, Hiroshi|Bhatia, Vikram|Mekky, Mohamed A|Tajika, Masahiro|Tanaka, Tsutomu|Ishihara, Makoto|Yogi, Tatsuji|Tsutumi, Hideharu|Fujiyoshi, Toshihisa|Sato, Takamitsu|Hieda, Nobuhiro|Yoshida, Tsuka
PMID: 25142799
Journal: Fam Cancer. 2015 Mar;14(1):95-103.
Title: Familial and sporadic pancreatic cancer share the same molecular pathogenesis.
Author: Norris, Alexis L|Roberts, Nicholas J|Jones, Sian|Wheelan, Sarah J|Papadopoulos, Nickolas|Vogelstein, Bert|Kinzler, Kenneth W|Hruban, Ralph H|Klein, Alison P|Eshleman, James R
PMID: 25240578
Journal: Cancer Lett. 2015 Jan 28;356(2 Pt B):613-27.
Title: Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the Wnt/beta-catenin signaling pathway.
Author: Xu, Wei|Wang, Ziwei|Zhang, Wei|Qian, Kun|Li, Hui|Kong, Dequan|Li, Yuqiang|Tang, Yucheng
PMID: 25305448
Journal: Radiology. 2015 Mar;274(3):790-9.
Title: Vascular endothelial growth factor receptor type 2-targeted contrast-enhanced US of pancreatic cancer neovasculature in a genetically engineered mouse model: potential for earlier detection.
Author: Pysz, Marybeth A|Machtaler, Steven B|Seeley, E Scott|Lee, John J|Brentnall, Teresa A|Rosenberg, Jarrett|Tranquart, Francois|Willmann, Jurgen K
PMID: 25322341
Journal: Clin Cancer Res. 2015 Jan 15;21(2):396-404.
Title: Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer.
Author: Alagesan, Brinda|Contino, Gianmarco|Guimaraes, Alex R|Corcoran, Ryan B|Deshpande, Vikram|Wojtkiewicz, Gregory R|Hezel, Aram F|Wong, Kwok-Kin|Loda, Massimo|Weissleder, Ralph|Benes, Cyril H|Engelman, Jeffrey|Bardeesy, Nabeel
PMID: 25348516
Journal: Cancer Discov. 2015 Jan;5(1):52-63.
Title: Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions.
Author: Liou, Geou-Yarh|Doppler, Heike|Necela, Brian|Edenfield, Brandy|Zhang, Lizhi|Dawson, David W|Storz, Peter
PMID: 25361845
Journal: Mol Cancer Ther. 2015 Jan;14(1):40-7.
Title: Modeling targeted inhibition of MEK and PI3 kinase in human pancreatic cancer.
Author: Junttila, Melissa R|Devasthali, Vidusha|Cheng, Jason H|Castillo, Joseph|Metcalfe, Ciara|Clermont, Anne C|Otter, Douglas Den|Chan, Emily|Bou-Reslan, Hani|Cao, Tim|Forrest, William|Nannini, Michelle A|French, Dorothy|Carano, Richard|Merchant, Mark|Hoeflich,
PMID: 25376606
Journal: Virchows Arch. 2015 Feb;466(2):237-41.
Title: Basaloid carcinoma of the pancreas--clinicopathological presentation and oncogenetic snapshot of a rare entity.
Author: Szasz, A Marcell|Szirtes, Ildiko|Tihanyi, Balazs|Barkaszi, Bernadett|Baranyai, Zsolt|Tihanyi, Tibor|Harsanyi, Laszlo|Timar, Jozsef|Kulka, Janina
PMID: 25432630
Journal: Adv Drug Deliv Rev. 2015 Jan;81:16-33.
Title: Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer.
Author: Rachagani, Satyanarayana|Macha, Muzafar A|Heimann, Nicholas|Seshacharyulu, Parthasarathy|Haridas, Dhanya|Chugh, Seema|Batra, Surinder K
PMID: 25453266
Journal: J Surg Res. 2015 Apr;194(2):481-7.
Title: Ablation of 5-lipoxygenase mitigates pancreatic lesion development.
Author: Knab, Lawrence M|Schultz, Michelle|Principe, Daniel R|Mascarinas, Windel E|Gounaris, Elias|Munshi, Hidayatullah G|Grippo, Paul J|Bentrem, David J
PMID: 25454978
Journal: Pancreatology. 2015 Mar-Apr;15(2):194-6.
Title: Intraductal papillary mucinous neoplasm in a neonate with congenital hyperinsulinism and a de novo germline SKIL gene mutation.
Author: Jiao, Yuchen|Lumpkins, Kimberly|Terhune, Julia|Hruban, Ralph H|Klein, Alison|Kinzler, Kenneth W|Papadopoulos, Nickolas|Vogelstein, Bert|Strauch, Eric
PMID: 25464936
Journal: Hum Pathol. 2015 Feb;46(2):202-9.
Title: Autophagy may occur at an early stage of cholangiocarcinogenesis via biliary intraepithelial neoplasia.
Author: Sasaki, Motoko|Nitta, Takeo|Sato, Yasunori|Nakanuma, Yasuni
PMID: 25466963
Journal: Clin Gastroenterol Hepatol. 2015 May;13(5):963-9.e4.
Title: KRAS and guanine nucleotide-binding protein mutations in pancreatic juice collected from the duodenum of patients at high risk for neoplasia undergoing endoscopic ultrasound.
Author: Eshleman, James R|Norris, Alexis L|Sadakari, Yoshihiko|Debeljak, Marija|Borges, Michael|Harrington, Colleen|Lin, Elaine|Brant, Aaron|Barkley, Thomas|Almario, J Alejandro|Topazian, Mark|Farrell, James|Syngal, Sapna|Lee, Jeffrey H|Yu, Jun|Hruban, Ralph H|Ka
PMID: 25481712
Journal: Clin Cancer Res. 2015 Feb 15;21(4):730-8.
Title: A phase Ib dose-escalation study of the oral pan-PI3K inhibitor buparlisib (BKM120) in combination with the oral MEK1/2 inhibitor trametinib (GSK1120212) in patients with selected advanced solid tumors.
Author: Bedard, Philippe L|Tabernero, Josep|Janku, Filip|Wainberg, Zev A|Paz-Ares, Luis|Vansteenkiste, Johan|Van Cutsem, Eric|Perez-Garcia, Jose|Stathis, Anastasios|Britten, Carolyn D|Le, Ngocdiep|Carter, Kirsten|Demanse, David|Csonka, Denes|Peters, Malte|Zubel,
PMID: 25500057
Journal: Oncogene. 2015 Sep 10;34(37):4867-78.
Title: MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and KRAS genes.
Author: Keklikoglou, I|Hosaka, K|Bender, C|Bott, A|Koerner, C|Mitra, D|Will, R|Woerner, A|Muenstermann, E|Wilhelm, H|Cao, Y|Wiemann, S
PMID: 25500542
Journal: Expert Rev Anticancer Ther. 2015 Apr;15(4):433-8.
Title: Targeting protein kinase C subtypes in pancreatic cancer.
Author: Storz, Peter
PMID: 25604078
Journal: J Mol Endocrinol. 2015 Apr;54(2):137-47.
Title: Whole-exome characterization of pancreatic neuroendocrine tumor cell lines BON-1 and QGP-1.
Author: Vandamme, Timon|Peeters, Marc|Dogan, Fadime|Pauwels, Patrick|Van Assche, Elvire|Beyens, Matthias|Mortier, Geert|Vandeweyer, Geert|de Herder, Wouter|Van Camp, Guy|Hofland, Leo J|Op de Beeck, Ken
PMID: 25612765
Journal: Surgery. 2015 Feb;157(2):260-8.
Title: Survival in ampullary cancer: potential role of different KRAS mutations.
Author: Valsangkar, Nakul P|Ingkakul, Thun|Correa-Gallego, Camilo|Mino-Kenudson, Mari|Masia, Ricard|Lillemoe, Keith D|Fernandez-del Castillo, Carlos|Warshaw, Andrew L|Liss, Andrew S|Thayer, Sarah P
PMID: 25616942
Journal: Gastroenterology. 2015 May;148(5):1024-1034.e9.
Title: NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.
Author: Chen, Nai-Ming|Singh, Garima|Koenig, Alexander|Liou, Geou-Yarh|Storz, Peter|Zhang, Jin-San|Regul, Lisanne|Nagarajan, Sankari|Kuhnemuth, Benjamin|Johnsen, Steven A|Hebrok, Matthias|Siveke, Jens|Billadeau, Daniel D|Ellenrieder, Volker|Hessmann, Elisabeth
PMID: 25623042
Journal: Clin Cancer Res. 2015 Apr 15;21(8):1944-50.
Title: Very Long-term Survival Following Resection for Pancreatic Cancer Is Not Explained by Commonly Mutated Genes: Results of Whole-Exome Sequencing Analysis.
Author: Dal Molin, Marco|Zhang, Ming|de Wilde, Roeland F|Ottenhof, Niki A|Rezaee, Neda|Wolfgang, Christopher L|Blackford, Amanda|Vogelstein, Bert|Kinzler, Kenneth W|Papadopoulos, Nickolas|Hruban, Ralph H|Maitra, Anirban|Wood, Laura D
PMID: 25623214
Journal: Clin Cancer Res. 2015 Apr 1;21(7):1549-57.
Title: Nonviral oncogenic antigens and the inflammatory signals driving early cancer development as targets for cancer immunoprevention.
Author: Chu, Nina J|Armstrong, Todd D|Jaffee, Elizabeth M
PMID: 25623216
Journal: Nat Commun. 2015 Jan 28;6:6175.
Title: ADAM8 as a drug target in pancreatic cancer.
Author: Schlomann, Uwe|Koller, Garrit|Conrad, Catharina|Ferdous, Taheera|Golfi, Panagiota|Garcia, Adolfo Molejon|Hofling, Sabrina|Parsons, Maddy|Costa, Patricia|Soper, Robin|Bossard, Maud|Hagemann, Thorsten|Roshani, Rozita|Sewald, Norbert|Ketchem, Randal R|Moss,
PMID: 25629724
Journal: Cancer Res. 2015 Feb 1;75(3):544-53.
Title: Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein.
Author: Kamphorst, Jurre J|Nofal, Michel|Commisso, Cosimo|Hackett, Sean R|Lu, Wenyun|Grabocka, Elda|Vander Heiden, Matthew G|Miller, George|Drebin, Jeffrey A|Bar-Sagi, Dafna|Thompson, Craig B|Rabinowitz, Joshua D
PMID: 25644265
Journal: Expert Rev Mol Diagn. 2015 Mar;15(3):325-8.
Title: Activating mutations of GNAS and KRAS in cystic fluid can help detect intraductal papillary mucinous neoplasms of the pancreas.
Author: Frampton, Adam E|Stebbing, Justin|Gall, Tamara M H|Silver, Benjamin|Jiao, Long R|Krell, Jonathan
PMID: 25656048
Journal: Gastroenterology. 2015 Jun;148(7):1452-65.
Title: Loss of Somatostatin Receptor Subtype 2 Promotes Growth of KRAS-Induced Pancreatic Tumors in Mice by Activating PI3K Signaling and Overexpression of CXCL16.
Author: Chalabi-Dchar, Mounira|Cassant-Sourdy, Stephanie|Duluc, Camille|Fanjul, Marjorie|Lulka, Hubert|Samain, Remi|Roche, Catherine|Breibach, Florence|Delisle, Marie-Bernadette|Poupot, Mary|Dufresne, Marlene|Shimaoka, Takeshi|Yonehara, Shin|Mathonnet, Muriel|Pyr
PMID: 25683115
Journal: Cancer Lett. 2015 May 1;360(2):227-33.
Title: Metabolic tumor burden is associated with major oncogenomic alterations and serum tumor markers in patients with resected pancreatic cancer.
Author: Shi, Si|Ji, Shunrong|Qin, Yi|Xu, Jin|Zhang, Bo|Xu, Wenyan|Liu, Jiang|Long, Jiang|Liu, Chen|Liu, Liang|Ni, Quanxing|Yu, Xianjun
PMID: 25687883
Journal: Nat Commun. 2015 Feb 20;6:6200.
Title: Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia.
Author: Liou, Geou-Yarh|Doppler, Heike|Braun, Ursula B|Panayiotou, Richard|Scotti Buzhardt, Michele|Radisky, Derek C|Crawford, Howard C|Fields, Alan P|Murray, Nicole R|Wang, Q Jane|Leitges, Michael|Storz, Peter
PMID: 25698580
Journal: Front Oncol. 2015 Feb 4;5:23.
Title: Impacts of activation of the mitogen-activated protein kinase pathway in pancreatic cancer.
Author: Furukawa, Toru
PMID: 25699241
Journal: Oncotarget. 2015 Mar 10;6(7):4553-61.
Title: Molecular landscape of pancreatic cancer: implications for current clinical trials.
Author: Heestand, Gregory M|Kurzrock, Razelle
PMID: 25714017
Journal: Mol Cancer Res. 2015 May;13(5):863-9.
Title: Detection of Tumor Suppressor Genes in Cancer Development by a Novel shRNA-Based Method.
Author: von Burstin, Johannes|Diersch, Sandra|Schneider, Gunter|Reichert, Maximilian|Rustgi, Anil K|Schmid, Roland M
PMID: 25724428
Journal: Cancer Res. 2015 Mar 15;75(6):1091-101.
Title: Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer.
Author: Pettazzoni, Piergiorgio|Viale, Andrea|Shah, Parantu|Carugo, Alessandro|Ying, Haoqiang|Wang, Huamin|Genovese, Giannicola|Seth, Sahil|Minelli, Rosalba|Green, Tessa|Huang-Hobbs, Emmet|Corti, Denise|Sanchez, Nora|Nezi, Luigi|Marchesini, Matteo|Kapoor, Avnish|
PMID: 25736685
Journal: Neoplasia. 2015 Feb;17(2):175-82.
Title: Constitutively active Akt1 cooperates with KRas(G12D) to accelerate in vivo pancreatic tumor onset and progression.
Author: Albury, Toya M|Pandey, Veethika|Gitto, Sarah B|Dominguez, Lisette|Spinel, Lina P|Talarchek, Jacqueline|Klein-Szanto, Andres J|Testa, Joseph R|Altomare, Deborah A
PMID: 25748236
Journal: Cell Res. 2015 May;25(5):561-73.
Title: ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer.
Author: Ji, Shunrong|Qin, Yi|Shi, Si|Liu, Xiangyuan|Hu, Hongli|Zhou, Hu|Gao, Jing|Zhang, Bo|Xu, Wenyan|Liu, Jiang|Liang, Dingkong|Liu, Liang|Liu, Chen|Long, Jiang|Zhou, Haijun|Chiao, Paul J|Xu, Jin|Ni, Quanxing|Gao, Daming|Yu, Xianjun
PMID: 25753158
Journal: Oncotarget. 2015 Apr 10;6(10):7504-21.
Title: TCGA data and patient-derived orthotopic xenografts highlight pancreatic cancer-associated angiogenesis.
Author: Gore, Jesse|Craven, Kelly E|Wilson, Julie L|Cote, Gregory A|Cheng, Monica|Nguyen, Hai V|Cramer, Harvey M|Sherman, Stuart|Korc, Murray
PMID: 25762644
Journal: Bioorg Med Chem. 2015 Apr 1;23(7):1386-94.
Title: Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor.
Author: Van Dort, Marcian E|Galban, Stefanie|Wang, Hanxiao|Sebolt-Leopold, Judith|Whitehead, Christopher|Hong, Hao|Rehemtulla, Alnawaz|Ross, Brian D
PMID: 25766633
Journal: Oncologist. 2015 Apr;20(4):e8-9.
Title: Allelic ratio of KRAS mutations in pancreatic cancer.
Author: Lennerz, Jochen K|Stenzinger, Albrecht
PMID: 25777349
Journal: Virchows Arch. 2015 Jun;466(6):665-74.
Title: GNAS mutation is a frequent event in pancreatic intraductal papillary mucinous neoplasms and associated adenocarcinomas.
Author: Hosoda, Waki|Sasaki, Eiichi|Murakami, Yoshiko|Yamao, Kenji|Shimizu, Yasuhiro|Yatabe, Yasushi
PMID: 25796395
Journal: Oncotarget. 2015 Mar 30;6(9):7209-20.
Title: Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis.
Author: Mitsuhashi, Kei|Nosho, Katsuhiko|Sukawa, Yasutaka|Matsunaga, Yasutaka|Ito, Miki|Kurihara, Hiroyoshi|Kanno, Shinichi|Igarashi, Hisayoshi|Naito, Takafumi|Adachi, Yasushi|Tachibana, Mami|Tanuma, Tokuma|Maguchi, Hiroyuki|Shinohara, Toshiya|Hasegawa, Tadashi|I
PMID: 25797243
Journal: Pancreas. 2015 May;44(4):547-50.
Title: Circulating tumor cells found in patients with localized and advanced pancreatic cancer.
Author: Kulemann, Birte|Pitman, Martha B|Liss, Andrew S|Valsangkar, Nakul|Fernandez-Del Castillo, Carlos|Lillemoe, Keith D|Hoeppner, Jens|Mino-Kenudson, Mari|Warshaw, Andrew L|Thayer, Sarah P
PMID: 25822154
Journal: Cancer. 2015 Jul 1;121(13):2271-80.
Title: Detection of K-ras gene mutation by liquid biopsy in patients with pancreatic cancer.
Author: Kinugasa, Hideaki|Nouso, Kazuhiro|Miyahara, Koji|Morimoto, Yuki|Dohi, Chihiro|Tsutsumi, Koichiro|Kato, Hironari|Matsubara, Takehiro|Okada, Hiroyuki|Yamamoto, Kazuhide
PMID: 25823825
Journal: Nat Commun. 2015 Apr 9;6:6744.
Title: Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets.
Author: Witkiewicz, Agnieszka K|McMillan, Elizabeth A|Balaji, Uthra|Baek, GuemHee|Lin, Wan-Chi|Mansour, John|Mollaee, Mehri|Wagner, Kay-Uwe|Koduru, Prasad|Yopp, Adam|Choti, Michael A|Yeo, Charles J|McCue, Peter|White, Michael A|Knudsen, Erik S
PMID: 25855536
Journal: Pancreas. 2015 May;44(4):583-9.
Title: Primary and liver metastasis-derived cell lines from KrasG12D; Trp53R172H; Pdx-1 Cre animals undergo apoptosis in response to triptolide.
Author: Sangwan, Veena|Banerjee, Sulagna|Jensen, Kelsey M|Chen, Zhiyu|Chugh, Rohit|Dudeja, Vikas|Vickers, Selwyn M|Saluja, Ashok K
PMID: 25875797
Journal: Pancreas. 2015 May;44(4):636-47.
Title: Metformin suppresses pancreatic tumor growth with inhibition of NFkappaB/STAT3 inflammatory signaling.
Author: Tan, Xiang-Lin|Bhattacharyya, Kalyan K|Dutta, Shamit K|Bamlet, William R|Rabe, Kari G|Wang, Enfeng|Smyrk, Thomas C|Oberg, Ann L|Petersen, Gloria M|Mukhopadhyay, Debabrata
PMID: 25875801
Journal: Gastroenterology. 2015 Jul;149(1):201-10.
Title: Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6C(low) F4/80(+) Extratumoral Macrophages.
Author: Beatty, Gregory L|Winograd, Rafael|Evans, Rebecca A|Long, Kristen B|Luque, Santiago L|Lee, Jae W|Clendenin, Cynthia|Gladney, Whitney L|Knoblock, Dawson M|Guirnalda, Patrick D|Vonderheide, Robert H
PMID: 25888329
Journal: Clin Cancer Res. 2015 May 1;21(9):2029-37.
Title: Precision Medicine for Advanced Pancreas Cancer: The Individualized Molecular Pancreatic Cancer Therapy (IMPaCT) Trial.
Author: Chantrill, Lorraine A|Nagrial, Adnan M|Watson, Clare|Johns, Amber L|Martyn-Smith, Mona|Simpson, Skye|Mead, Scott|Jones, Marc D|Samra, Jaswinder S|Gill, Anthony J|Watson, Nicole|Chin, Venessa T|Humphris, Jeremy L|Chou, Angela|Brown, Belinda|Morey, Adrienne
PMID: 25896973
Journal: Oncoscience. 2015 Mar 28;2(3):247-51.
Title: Inflammatory macrophages in pancreatic acinar cell metaplasia and initiation of pancreatic cancer.
Author: Liou, Geou-Yarh|Storz, Peter
PMID: 25897428
Journal: PLoS One. 2015 Apr 23;10(4):e0125515.
Title: Deregulation of the MiR-193b-KRAS Axis Contributes to Impaired Cell Growth in Pancreatic Cancer.
Author: Jin, Xianglan|Sun, Yang|Yang, Haiyan|Li, Ji|Yu, Shuangni|Chang, Xiaoyan|Lu, Zhaohui|Chen, Jie
PMID: 25905463
Journal: Mol Cancer Ther. 2015 Jul;14(7):1532-9.
Title: Combined Inhibition of Cyclin-Dependent Kinases (Dinaciclib) and AKT (MK-2206) Blocks Pancreatic Tumor Growth and Metastases in Patient-Derived Xenograft Models.
Author: Hu, Chaoxin|Dadon, Tikva|Chenna, Venugopal|Yabuuchi, Shinichi|Bannerji, Rajat|Booher, Robert|Strack, Peter|Azad, Nilofer|Nelkin, Barry D|Maitra, Anirban
PMID: 25931518
Journal: Carcinogenesis. 2015 Jul;36(7):730-8.
Title: Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism.
Author: Bednar, Filip|Schofield, Heather K|Collins, Meredith A|Yan, Wei|Zhang, Yaqing|Shyam, Nikhil|Eberle, Jaime A|Almada, Luciana L|Olive, Kenneth P|Bardeesy, Nabeel|Fernandez-Zapico, Martin E|Nakada, Daisuke|Simeone, Diane M|Morrison, Sean J|Pasca di Magliano,
PMID: 25939753
Journal: Cancer Res. 2015 Jul 1;75(13):2629-40.
Title: Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer.
Author: Takeuchi, Shintaro|Baghdadi, Muhammad|Tsuchikawa, Takahiro|Wada, Haruka|Nakamura, Toru|Abe, Hirotake|Nakanishi, Sayaka|Usui, Yuu|Higuchi, Kohtaro|Takahashi, Mizuna|Inoko, Kazuho|Sato, Syoki|Takano, Hironobu|Shichinohe, Toshiaki|Seino, Ken-ichiro|Hirano, S
PMID: 25952647
Journal: Chin J Cancer. 2015 Apr 8;34(4):166-76.
Title: Selective killing of K-ras-transformed pancreatic cancer cells by targeting NAD(P)H oxidase.
Author: Wang, Peng|Sun, Yi-Chen|Lu, Wen-Hua|Huang, Peng|Hu, Yumin
PMID: 25963558
Journal: Cancer Res. 2015 Jul 15;75(14):2907-15.
Title: Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion.
Author: Razidlo, Gina L|Magnine, Christopher|Sletten, Arthur C|Hurley, Rachel M|Almada, Luciana L|Fernandez-Zapico, Martin E|Ji, Baoan|McNiven, Mark A
PMID: 25977335
Journal: Oncotarget. 2015 Aug 21;6(24):20132-44.
Title: Combined targeting of EGFR/HER promotes anti-tumor efficacy in subsets of KRAS mutant lung cancer resistant to single EGFR blockade.
Author: Umelo, Ijeoma Adaku|De Wever, Olivier|Kronenberger, Peter|Van Deun, Jan|Noor, Alfiah|Singh, Kshitiz|Teugels, Erik|Chen, Gang|Bracke, Marc|De Greve, Jacques
PMID: 25992771
Journal: Recenti Prog Med. 2015 May;106(5):208-16.
Title: [Treatment of pancreatic cancer. Actuality and perspective].
Author: Bittoni, Alessandro|Andrikou, Kalliopi|Lanese, Andrea|Santoni, Matteo|Pellei, Chiara|Faloppi, Luca|Del Prete, Michela|Giampieri, Riccardo|Cascinu, Stefano
PMID: 25994537
Journal: Clin Cancer Res. 2015 Aug 1;21(15):3369-71.
Title: Obesity, Intrapancreatic Fatty Infiltration, and Pancreatic Cancer.
Author: Wang, Hua|Maitra, Anirban|Wang, Huamin
PMID: 25995340
Journal: J Nutr Biochem. 2015 Aug;26(8):797-807.
Title: EGR-1/Bax pathway plays a role in vitamin E delta-tocotrienol-induced apoptosis in pancreatic cancer cells.
Author: Wang, Chen|Husain, Kazim|Zhang, Anying|Centeno, Barbara A|Chen, Dung-Tsa|Tong, Zhongsheng|Sebti, Said M|Malafa, Mokenge P
PMID: 25997867
Journal: Cell. 2015 Jun 4;161(6):1345-60.
Title: RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma.
Author: Whittle, Martin C|Izeradjene, Kamel|Rani, P Geetha|Feng, Libing|Carlson, Markus A|DelGiorno, Kathleen E|Wood, Laura D|Goggins, Michael|Hruban, Ralph H|Chang, Amy E|Calses, Philamer|Thorsen, Shelley M|Hingorani, Sunil R
PMID: 26004068
Journal: Oncotarget. 2015 Sep 15;6(27):24560-70.
Title: RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients.
Author: Golan, Talia|Khvalevsky, Elina Zorde|Hubert, Ayala|Gabai, Rachel Malka|Hen, Naama|Segal, Amiel|Domb, Abraham|Harari, Gil|David, Eliel Ben|Raskin, Stephen|Goldes, Yuri|Goldin, Eran|Eliakim, Rami|Lahav, Maor|Kopleman, Yael|Dancour, Alain|Shemi, Amotz|Galun,
PMID: 26009994
Journal: Clin Cancer Res. 2015 Oct 1;21(19):4473-81.
Title: New DNA Methylation Markers for Pancreatic Cancer: Discovery, Tissue Validation, and Pilot Testing in Pancreatic Juice.
Author: Kisiel, John B|Raimondo, Massimo|Taylor, William R|Yab, Tracy C|Mahoney, Douglas W|Sun, Zhifu|Middha, Sumit|Baheti, Saurabh|Zou, Hongzhi|Smyrk, Thomas C|Boardman, Lisa A|Petersen, Gloria M|Ahlquist, David A
PMID: 26023084
Journal: Oncol Rep. 2015 Aug;34(2):699-706.
Title: U0126 inhibits pancreatic cancer progression via the KRAS signaling pathway in a zebrafish xenotransplantation model.
Author: Guo, Meng|Wei, Huanhuan|Hu, Jingying|Sun, Shaoyang|Long, Jiang|Wang, Xu
PMID: 26035715
Journal: Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2392-403.
Title: Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells.
Author: Trehoux, Solange|Lahdaoui, Fatima|Delpu, Yannick|Renaud, Florence|Leteurtre, Emmanuelle|Torrisani, Jerome|Jonckheere, Nicolas|Van Seuningen, Isabelle
PMID: 26036346
Journal: Oncotarget. 2015 Jul 20;6(20):18162-73.
Title: Erlotinib is effective in pancreatic cancer with epidermal growth factor receptor mutations: a randomized, open-label, prospective trial.
Author: Wang, Jack P|Wu, Chen-Yi|Yeh, Yi-Cheng|Shyr, Yi-Ming|Wu, Ying-Ying|Kuo, Chen-Yu|Hung, Yi-Ping|Chen, Ming-Huang|Lee, Wei-Ping|Luo, Jiing-Chyuan|Chao, Yee|Li, Chung-Pin
PMID: 26046796
Journal: EMBO Mol Med. 2015 Aug;7(8):1063-76.
Title: Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.
Author: Miller, Bryan W|Morton, Jennifer P|Pinese, Mark|Saturno, Grazia|Jamieson, Nigel B|McGhee, Ewan|Timpson, Paul|Leach, Joshua|McGarry, Lynn|Shanks, Emma|Bailey, Peter|Chang, David|Oien, Karin|Karim, Saadia|Au, Amy|Steele, Colin|Carter, Christopher Ross|McKay
PMID: 26077591
Journal: Sci Rep. 2015 Jun 16;5:11385.
Title: A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer.
Author: Ohnmacht, Stephan A|Marchetti, Chiara|Gunaratnam, Mekala|Besser, Rachael J|Haider, Shozeb M|Di Vita, Gloria|Lowe, Helen L|Mellinas-Gomez, Maria|Diocou, Seckou|Robson, Mathew|Sponer, Jiri|Islam, Barira|Pedley, R Barbara|Hartley, John A|Neidle, Stephen
PMID: 26077929
Journal: Ann Oncol. 2015 Sep;26(9):1923-9.
Title: A phase II/III randomized study to compare the efficacy and safety of rigosertib plus gemcitabine versus gemcitabine alone in patients with previously untreated metastatic pancreatic cancer.
Author: O'Neil, B H|Scott, A J|Ma, W W|Cohen, S J|Leichman, L|Aisner, D L|Menter, A R|Tejani, M A|Cho, J K|Granfortuna, J|Coveler, A L|Olowokure, O O|Baranda, J C|Cusnir, M|Phillip, P|Boles, J|Nazemzadeh, R|Rarick, M|Cohen, D J|Radford, J|Fehrenbacher, L|Bajaj, R
PMID: 26091808
Journal: Oncoscience. 2015 May 2;2(5):517-32.
Title: Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells.
Author: Eling, Nils|Reuter, Lukas|Hazin, John|Hamacher-Brady, Anne|Brady, Nathan R
PMID: 26097885
Journal: Nature. 2015 Jul 9;523(7559):177-82.
Title: Glypican-1 identifies cancer exosomes and detects early pancreatic cancer.
Author: Melo, Sonia A|Luecke, Linda B|Kahlert, Christoph|Fernandez, Agustin F|Gammon, Seth T|Kaye, Judith|LeBleu, Valerie S|Mittendorf, Elizabeth A|Weitz, Juergen|Rahbari, Nuh|Reissfelder, Christoph|Pilarsky, Christian|Fraga, Mario F|Piwnica-Worms, David|Kalluri,
PMID: 26106858
Journal: Int J Biochem Cell Biol. 2015 Aug;65:288-99.
Title: Keap1-Nrf2 signalling in pancreatic cancer.
Author: Hayes, Alastair J|Skouras, Christos|Haugk, Beate|Charnley, Richard M
PMID: 26117456
Journal: Bull Cancer. 2015 Jun;102(6 Suppl 1):S53-61.
Title: [Advance in the biology of pancreatic of cancer].
Author: Buscail, Louis|Bournet, Barbara|Dufresne, Marlene|Torrisani, Jerome|Cordelier, Pierre
PMID: 26118878
Journal: Anticancer Res. 2015 Jul;35(7):3821-8.
Title: Establishment and Characterization of Two Novel Human Pancreatic Carcinoma Cell Lines.
Author: Hirano, Katsuhisa|Okumura, Tomoyuki|Shimada, Yutaka|Watanabe, Toru|Yamaguchi, Tetsuji|Nagata, Takuya|Tsukada, Kazuhiro
PMID: 26124327
Journal: Oncol Lett. 2015 May;9(5):2112-2118.
Title: In vivo(18)F-fluorodeoxyglucose-positron emission tomography/computed tomography imaging of pancreatic tumors in a transgenic rat model carrying the human KRAS(G12V) oncogene.
Author: Shibata, Koji|Fukamachi, Katsumi|Tsuji, Atsushi|Saga, Tsuneo|Futakuchi, Mitsuru|Nagino, Masato|Tsuda, Hiroyuki|Suzui, Masumi
PMID: 26137023
Journal: Elife. 2015 Jul 7;4.
Title: The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma.
Author: Krah, Nathan M|De La O, Jean-Paul|Swift, Galvin H|Hoang, Chinh Q|Willet, Spencer G|Chen Pan, Fong|Cash, Gabriela M|Bronner, Mary P|Wright, Christopher Ve|MacDonald, Raymond J|Murtaugh, L Charles
PMID: 26151762
Journal: Oncoimmunology. 2015 Mar 19;4(6):e1008794.
Title: The crosstalk between acinar cells with Kras mutations and M1-polarized macrophages leads to initiation of pancreatic precancerous lesions.
Author: Storz, Peter
PMID: 26155420
Journal: BMC Cancer. 2015 Jul 10;15:513.
Title: The combination of intravenous Reolysin and gemcitabine induces reovirus replication and endoplasmic reticular stress in a patient with KRAS-activated pancreatic cancer.
Author: Mahalingam, Devalingam|Patel, Sukeshi|Nuovo, Gerard|Gill, George|Selvaggi, Giovanni|Coffey, Matt|Nawrocki, Steffan T
PMID: 26156229
Journal: Oncotarget. 2015 Jun 30;6(18):15814-27.
Title: A MEK/PI3K/HDAC inhibitor combination therapy for KRAS mutant pancreatic cancer cells.
Author: Ischenko, Irene|Petrenko, Oleksi|Hayman, Michael J
PMID: 26158412
Journal: Oncotarget. 2015 Jun 30;6(18):15788-801.
Title: Selective impact of CDK4/6 suppression on patient-derived models of pancreatic cancer.
Author: Witkiewicz, Agnieszka K|Borja, Nicholas A|Franco, Jorge|Brody, Jonathan R|Yeo, Charles J|Mansour, John|Choti, Michael A|McCue, Peter|Knudsen, Erik S
PMID: 26158861
Journal: Oncotarget. 2015 Jul 10;6(19):16832-47.
Title: Targeting cancer cell metabolism in pancreatic adenocarcinoma.
Author: Cohen, Romain|Neuzillet, Cindy|Tijeras-Raballand, Annemilai|Faivre, Sandrine|de Gramont, Armand|Raymond, Eric
PMID: 26164081
Journal: Nat Rev Clin Oncol. 2015 Aug;12(8):442-4.
Title: Pancreatic cancer: Targeting KRAS and the vitamin D receptor via microtubules.
Author: Basseville, Agnes|Bates, Susan|Fojo, Tito
PMID: 26169922
Journal: Expert Rev Gastroenterol Hepatol. 2015;9(9):1143-6.
Title: Protein kinase D enzymes: novel kinase targets in pancreatic cancer.
Author: Liou, Geou-Yarh|Storz, Peter
PMID: 26174103
Journal: Genes Dev. 2015 Jul 15;29(14):1576-85.
Title: Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing.
Author: Chiou, Shin-Heng|Winters, Ian P|Wang, Jing|Naranjo, Santiago|Dudgeon, Crissy|Tamburini, Fiona B|Brady, Jennifer J|Yang, Dian|Gruner, Barbara M|Chuang, Chen-Hua|Caswell, Deborah R|Zeng, Hong|Chu, Pauline|Kim, Grace E|Carpizo, Darren R|Kim, Seung K|Winslow,
PMID: 26178787
Journal: Drug Des Devel Ther. 2015 Jul 7;9:3529-45.
Title: Pancreatic cancer: optimizing treatment options, new, and emerging targeted therapies.
Author: Chiorean, Elena Gabriela|Coveler, Andrew L
PMID: 26185420
Journal: Nanomedicine. 2015 Nov;11(8):2061-70.
Title: Anthothecol-encapsulated PLGA nanoparticles inhibit pancreatic cancer stem cell growth by modulating sonic hedgehog pathway.
Author: Verma, Raj Kumar|Yu, Wei|Singh, Surya Pratap|Shankar, Sharmila|Srivastava, Rakesh K
PMID: 26199979
Journal: Biomater Sci. 2015 Jan;3(1):192-202.
Title: Assembling Mn:ZnSe quantum dots-siRNA nanoplexes for gene silencing in tumor cells.
Author: Wang, Yucheng|Yang, Chengbin|Hu, Rui|Toh, Hui Ting|Liu, Xin|Lin, Guimiao|Yin, Feng|Yoon, Ho Sup|Yong, Ken-Tye
PMID: 26214202
Journal: Cancer Genet. 2015 Sep;208(9):441-7.
Title: Diagnostic yield of targeted next generation sequencing in various cancer types: an information-theoretic approach.
Author: Hagemann, Ian S|O'Neill, Patrick K|Erill, Ivan|Pfeifer, John D
PMID: 26227479
Journal: Gastroenterology. 2015 Nov;149(6):1501-10.
Title: A combination of molecular markers and clinical features improve the classification of pancreatic cysts.
Author: Springer, Simeon|Wang, Yuxuan|Dal Molin, Marco|Masica, David L|Jiao, Yuchen|Kinde, Isaac|Blackford, Amanda|Raman, Siva P|Wolfgang, Christopher L|Tomita, Tyler|Niknafs, Noushin|Douville, Christopher|Ptak, Janine|Dobbyn, Lisa|Allen, Peter J|Klimstra, David
PMID: 26253305
Journal: Gastroenterology. 2015 Dec;149(7):1932-1943.e9.
Title: Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.
Author: Nagathihalli, Nagaraj S|Castellanos, Jason A|Shi, Chanjuan|Beesetty, Yugandhar|Reyzer, Michelle L|Caprioli, Richard|Chen, Xi|Walsh, Alex J|Skala, Melissa C|Moses, Harold L|Merchant, Nipun B
PMID: 26255562
Journal: Adv Biol Regul. 2015 Sep;59:65-81.
Title: Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells.
Author: Fitzgerald, Timothy L|Lertpiriyapong, Kvin|Cocco, Lucio|Martelli, Alberto M|Libra, Massimo|Candido, Saverio|Montalto, Giuseppe|Cervello, Melchiorre|Steelman, Linda|Abrams, Stephen L|McCubrey, James A
PMID: 26257206
Journal: Cancer Res. 2015 Nov 1;75(21):4582-92.
Title: Cancer stem cell marker phenotypes are reversible and functionally homogeneous in a preclinical model of pancreatic cancer.
Author: Dosch, Joseph S|Ziemke, Elizabeth K|Shettigar, Amrith|Rehemtulla, Alnawaz|Sebolt-Leopold, Judith S
PMID: 26359451
Journal: World J Gastrointest Oncol. 2015 Sep 15;7(9):132-40.
Title: Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review.
Author: Borazanci, Erkut|Millis, Sherri Z|Korn, Ron|Han, Haiyong|Whatcott, Clifford J|Gatalica, Zoran|Barrett, Michael T|Cridebring, Derek|Von Hoff, Daniel D
PMID: 26380056
Journal: Cancer Res. 2015 Nov 15;75(22):4852-62.
Title: IL17 Functions through the Novel REG3beta-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer.
Author: Loncle, Celine|Bonjoch, Laia|Folch-Puy, Emma|Lopez-Millan, Maria Belen|Lac, Sophie|Molejon, Maria Ines|Chuluyan, Eduardo|Cordelier, Pierre|Dubus, Pierre|Lomberk, Gwen|Urrutia, Raul|Closa, Daniel|Iovanna, Juan L
PMID: 26404002
Journal: Oncotarget. 2015 Nov 24;6(37):39564-77.
Title: Multistep, effective drug distribution within solid tumors.
Author: Shemi, Amotz|Khvalevsky, Elina Zorde|Gabai, Rachel Malka|Domb, Abraham|Barenholz, Yechezkel
PMID: 26416413
Journal: Dis Model Mech. 2015 Oct 1;8(10):1185-200.
Title: GEMMs as preclinical models for testing pancreatic cancer therapies.
Author: Gopinathan, Aarthi|Morton, Jennifer P|Jodrell, Duncan I|Sansom, Owen J
PMID: 26438692
Journal: Oncotarget. 2015 Oct 13;6(31):32039-60.
Title: PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth.
Author: Sharma, Narinder|Nanta, Rajesh|Sharma, Jay|Gunewardena, Sumedha|Singh, Karan P|Shankar, Sharmila|Srivastava, Rakesh K
PMID: 26451606
Journal: Oncotarget. 2015 Oct 13;6(31):32154-60.
Title: Hypoxia-induced endoplasmic reticulum stress characterizes a necrotic phenotype of pancreatic cancer.
Author: Kong, Bo|Cheng, Tao|Wu, Weiwei|Regel, Ivonne|Raulefs, Susanne|Friess, Helmut|Erkan, Mert|Esposito, Irene|Kleeff, Jorg|Michalski, Christoph W
PMID: 26452217
Journal: PLoS One. 2015 Oct 9;10(10):e0140253.
Title: Wild-Type Hras Suppresses the Earliest Stages of Tumorigenesis in a Genetically Engineered Mouse Model of Pancreatic Cancer.
Author: Weyandt, Jamie D|Lampson, Benjamin L|Tang, Sherry|Mastrodomenico, Matthew|Cardona, Diana M|Counter, Christopher M
PMID: 26452271
Journal: Cancer Metab. 2015 Oct 12;3:12.
Title: Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ss-lapachone.
Author: Chakrabarti, Gaurab|Moore, Zachary R|Luo, Xiuquan|Ilcheva, Mariya|Ali, Aktar|Padanad, Mahesh|Zhou, Yunyun|Xie, Yang|Burma, Sandeep|Scaglioni, Pier P|Cantley, Lewis C|DeBerardinis, Ralph J|Kimmelman, Alec C|Lyssiotis, Costas A|Boothman, David A
PMID: 26462257
Journal: Int J Clin Exp Pathol. 2015 Aug 1;8(8):9672-80. eCollection 2015.
Title: Multifocal intraductal tubulopapillary neoplasm of the pancreas with total pancreatectomy: report of a case and review of literature.
Author: Kolby, David|Thilen, Johan|Andersson, Roland|Sasor, Agata|Ansari, Daniel
PMID: 26464736
Journal: Biochim Biophys Acta. 2015 Dec;1849(12):1375-84.
Title: The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-kappaB and RalB signaling pathways.
Author: Vasseur, Romain|Skrypek, Nicolas|Duchene, Belinda|Renaud, Florence|Martinez-Maqueda, Daniel|Vincent, Audrey|Porchet, Nicole|Van Seuningen, Isabelle|Jonckheere, Nicolas
PMID: 26477488
Journal: Nat Med. 2015 Nov;21(11):1337-43.
Title: Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression.
Author: Alam, Muhammad S|Gaida, Matthias M|Bergmann, Frank|Lasitschka, Felix|Giese, Thomas|Giese, Nathalia A|Hackert, Thilo|Hinz, Ulf|Hussain, S Perwez|Kozlov, Serguei V|Ashwell, Jonathan D
PMID: 26479921
Journal: BMC Cancer. 2015 Oct 24;15:797.
Title: Circulating tumor cells (Ctc) and kras mutant circulating free Dna (cfdna) detection in peripheral blood as biomarkers in patients diagnosed with exocrine pancreatic cancer.
Author: Earl, Julie|Garcia-Nieto, Sandra|Martinez-Avila, Jose Carlos|Montans, Jose|Sanjuanbenito, Alfonso|Rodriguez-Garrote, Mercedes|Lisa, Eduardo|Mendia, Elena|Lobo, Eduardo|Malats, Nuria|Carrato, Alfredo|Guillen-Ponce, Carmen
PMID: 26498594
Journal: Cell Cycle. 2015;14(23):3713-24.
Title: MEK inhibitor GSK1120212-mediated radiosensitization of pancreatic cancer cells involves inhibition of DNA double-strand break repair pathways.
Author: Estrada-Bernal, Adriana|Chatterjee, Moumita|Haque, S Jaharul|Yang, Linlin|Morgan, Meredith A|Kotian, Shweta|Morrell, David|Chakravarti, Arnab|Williams, Terence M
PMID: 26505547
Journal: Cancer Growth Metastasis. 2015 Oct 19;8(Suppl 1):95-113.
Title: Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways.
Author: Padavano, Julianna|Henkhaus, Rebecca S|Chen, Hwudaurw|Skovan, Bethany A|Cui, Haiyan|Ignatenko, Natalia A
PMID: 26512205
Journal: Oncotarget. 2015 Nov 24;6(37):40295-309.
Title: Changes in microRNA (miRNA) expression during pancreatic cancer development and progression in a genetically engineered KrasG12D;Pdx1-Cre mouse (KC) model.
Author: Rachagani, Satyanarayana|Macha, Muzafar A|Menning, Melanie S|Dey, Parama|Pai, Priya|Smith, Lynette M|Mo, Yin-Yuan|Batra, Surinder K
PMID: 26516699
Journal: J Clin Oncol. 2015 Dec 20;33(36):4284-92.
Title: Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer.
Author: Catenacci, Daniel V T|Junttila, Melissa R|Karrison, Theodore|Bahary, Nathan|Horiba, Margit N|Nattam, Sreenivasa R|Marsh, Robert|Wallace, James|Kozloff, Mark|Rajdev, Lakshmi|Cohen, Deirdre|Wade, James|Sleckman, Bethany|Lenz, Heinz-Josef|Stiff, Patrick|Kuma
PMID: 26527777
Journal: PLoS One. 2015 Nov 10;10(11):e0142631.
Title: Whole Exome Sequencing of Rapid Autopsy Tumors and Xenograft Models Reveals Possible Driver Mutations Underlying Tumor Progression.
Author: Xie, Tao|Musteanu, Monica|Lopez-Casas, Pedro P|Shields, David J|Olson, Peter|Rejto, Paul A|Hidalgo, Manuel
PMID: 26555578
Journal: Oncotarget. 2015 Dec 29;6(42):44509-22.
Title: Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer.
Author: Mace, Thomas A|Shakya, Reena|Elnaggar, Omar|Wilson, Kristin|Komar, Hannah M|Yang, Jennifer|Pitarresi, Jason R|Young, Gregory S|Ostrowski, Michael C|Ludwig, Thomas|Bekaii-Saab, Tanios|Bloomston, Mark|Lesinski, Gregory B
PMID: 26575024
Journal: Pathol Res Pract. 2015 Dec;211(12):1034-9.
Title: A case of MUC5AC-positive intraductal neoplasm of the pancreas classified as an intraductal tubulopapillary neoplasm?
Author: Muraki, Takashi|Uehara, Takeshi|Sano, Kenji|Oota, Hiroyoshi|Yoshizawa, Akihiko|Asaka, Shiho|Tateishi, Ayako|Otsuki, Toshiaki|Shingu, Kunihiko|Matoba, Hisanori|Kobayashi, Shota|Ichimata, Shojiro|Watanabe, Takayuki|Itou, Tetsuya|Tanaka, Eiji
PMID: 26586167
Journal: Hepatobiliary Surg Nutr. 2015 Oct;4(5):325-35.
Title: Pancreatic cancer and thromboembolic disease, 150 years after Trousseau.
Author: Ansari, David|Ansari, Daniel|Andersson, Roland|Andren-Sandberg, Ake
PMID: 26605280
Journal: Sci Rep. 2015 Nov 30;5:17549.
Title: Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation.
Author: Grasso, Daniel|Bintz, Jennifer|Lomberk, Gwen|Molejon, Maria Ines|Loncle, Celine|Garcia, Maria Noe|Lopez, Maria Belen|Urrutia, Raul|Iovanna, Juan L
PMID: 26617245
Journal: Sci Rep. 2015 Dec 16;5:18425.
Title: Clinical utility of circulating tumor DNA for molecular assessment in pancreatic cancer.
Author: Takai, Erina|Totoki, Yasushi|Nakamura, Hiromi|Morizane, Chigusa|Nara, Satoshi|Hama, Natsuko|Suzuki, Masami|Furukawa, Eisaku|Kato, Mamoru|Hayashi, Hideyuki|Kohno, Takashi|Ueno, Hideki|Shimada, Kazuaki|Okusaka, Takuji|Nakagama, Hitoshi|Shibata, Tatsuhiro|Ya
PMID: 26669280
Journal: J Pathol Clin Res. 2015 Feb 2;1(2):76-82.
Title: Metachronous pancreatic cancer originating from disseminated founder pancreatic intraductal neoplasias (PanINs).
Author: Imai, Koji|Karasaki, Hidenori|Ono, Yusuke|Sasajima, Junpei|Chiba, Shin-Ichi|Funakoshi, Hiroshi|Muraki, Miho|Hanaoka, Hideki|Furukawa, Takahisa|Furukawa, Hiroyuki|Kono, Toru|Nagashima, Kazuo|Mizukami, Yusuke
PMID: 27499895
Journal: Redox Biol. 2015 Aug;5:414.
Title: Activation Of Wild-Type Hras Suppresses The Earliest Stages Of Pancreatic Cancer.
Author: Weyandt, Jamie
PMID: 28162272
Journal: Oncogene. 2016 May 12;35(19):2485-95.
Title: Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer.
Author: Zhang, S|Chung, W-C|Xu, K
PMID: 26279302
Journal: Acta Biochim Biophys Sin (Shanghai). 2016 Jan;48(1):27-38.
Title: RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
Author: Fang, Bingliang
PMID: 26350096
Journal: Gastroenterology. 2016 Jan;150(1):218-228.e12.
Title: Loss of Activin Receptor Type 1B Accelerates Development of Intraductal Papillary Mucinous Neoplasms in Mice With Activated KRAS.
Author: Qiu, Wanglong|Tang, Sophia M|Lee, Sohyae|Turk, Andrew T|Sireci, Anthony N|Qiu, Anne|Rose, Christian|Xie, Chuangao|Kitajewski, Jan|Wen, Hui-Ju|Crawford, Howard C|Sims, Peter A|Hruban, Ralph H|Remotti, Helen E|Su, Gloria H
PMID: 26408346
Journal: Oncogene. 2016 Apr 28;35(17):2223-34.
Title: APC haploinsufficiency coupled with p53 loss sufficiently induces mucinous cystic neoplasms and invasive pancreatic carcinoma in mice.
Author: Kuo, T-L|Weng, C-C|Kuo, K-K|Chen, C-Y|Wu, D-C|Hung, W-C|Cheng, K-H
PMID: 26411367
Journal: Hepatol Res. 2016 Jun;46(7):713-8.
Title: Intraductal tubulopapillary neoplasm of the bile duct: A case report and review of the published work.
Author: Nakagawa, Takashi|Arisaka, Yoshifumi|Ajiki, Tetsuo|Fujikura, Kohei|Masuda, Atsuhiro|Takenaka, Mamoru|Shiomi, Hideyuki|Okabe, Yoshihiro|Fukumoto, Takumi|Ku, Yonson|Azuma, Takeshi|Zen, Yoh
PMID: 26459784
Journal: Clin Cancer Res. 2016 Mar 15;22(6):1432-44.
Title: IL1 Receptor Antagonist Inhibits Pancreatic Cancer Growth by Abrogating NF-kappaB Activation.
Author: Zhuang, Zhuonan|Ju, Huai-Qiang|Aguilar, Mitzi|Gocho, Takashi|Li, Hao|Iida, Tomonori|Lee, Harold|Fan, Xiaoqiang|Zhou, Haijun|Ling, Jianhua|Li, Zhongkui|Fu, Jie|Wu, Min|Li, Min|Melisi, Davide|Iwakura, Yoichiro|Xu, Kesen|Fleming, Jason B|Chiao, Paul J
PMID: 26500238
Journal: Proteomics. 2016 Feb;16(3):516-31.
Title: Surveying the serologic proteome in a tissue-specific kras(G12D) knockin mouse model of pancreatic cancer.
Author: Ludwig, Michael R|Kojima, Kyoko|Bowersock, Gregory J|Chen, Dongquan|Jhala, Nirag C|Buchsbaum, Donald J|Grizzle, William E|Klug, Christopher A|Mobley, James A
PMID: 26572242
Journal: J Gastrointest Surg. 2016 Jan;20(1):53-65; discussion 65.
Title: A Novel Immunocompetent Mouse Model of Pancreatic Cancer with Robust Stroma: a Valuable Tool for Preclinical Evaluation of New Therapies.
Author: Majumder, Kaustav|Arora, Nivedita|Modi, Shrey|Chugh, Rohit|Nomura, Alice|Giri, Bhuwan|Dawra, Rajinder|Ramakrishnan, Sundaram|Banerjee, Sulagna|Saluja, Ashok|Dudeja, Vikas
PMID: 26582596
Journal: Oncogene. 2016 Aug 11;35(32):4282-8.
Title: p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells.
Author: Bailey, J M|Hendley, A M|Lafaro, K J|Pruski, M A|Jones, N C|Alsina, J|Younes, M|Maitra, A|McAllister, F|Iacobuzio-Donahue, C A|Leach, S D
PMID: 26592447
Journal: Oncogene. 2016 Jul 28;35(30):3897-908.
Title: Regulation of oncogenic KRAS signaling via a novel KRAS-integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells.
Author: Chu, P-C|Yang, M-C|Kulp, S K|Salunke, S B|Himmel, L E|Fang, C-S|Jadhav, A M|Shan, Y-S|Lee, C-T|Lai, M-D|Shirley, L A|Bekaii-Saab, T|Chen, C-S
PMID: 26616862
Journal: Hum Pathol. 2016 Feb;48:117-21.
Title: Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia.
Author: Ma, Changqing|Gocke, Christopher D|Hruban, Ralph H|Belchis, Deborah A
PMID: 26626780
Journal: Target Oncol. 2016 Jun;11(3):371-81.
Title: Afatinib, an Irreversible EGFR Family Inhibitor, Shows Activity Toward Pancreatic Cancer Cells, Alone and in Combination with Radiotherapy, Independent of KRAS Status.
Author: Huguet, Florence|Fernet, Marie|Giocanti, Nicole|Favaudon, Vincent|Larsen, Annette K
PMID: 26668065
Journal: Cancer Lett. 2016 Feb 28;371(2):187-93.
Title: Inhibition of mutant KrasG12D-initiated murine pancreatic carcinoma growth by a dual c-Raf and soluble epoxide hydrolase inhibitor t-CUPM.
Author: Liao, Jie|Hwang, Sung Hee|Li, Haonan|Yang, Yihe|Yang, Jun|Wecksler, Aaron T|Liu, Jun-Yan|Hammock, Bruce D|Yang, Guang-Yu
PMID: 26683769
Journal: Pancreas. 2016 Jul;45(6):900-7.
Title: Alterations in Tumor DNA Are Related to Short Postoperative Survival in Patients Resected for Pancreatic Carcinoma Aimed at Cure.
Author: Asting, Annika Gustafsson|Ljungman, David|Caren, Helena|Dambrauskas, Zilvinas|Iresjo, Britt-Marie|Hyltander, Anders|Naredi, Peter|Lundholm, Kent
PMID: 26684859
Journal: Stem Cells Int. 2016;2016:5272498.
Title: NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation.
Author: Hessmann, Elisabeth|Zhang, Jin-San|Chen, Nai-Ming|Hasselluhn, Marie|Liou, Geou-Yarh|Storz, Peter|Ellenrieder, Volker|Billadeau, Daniel D|Koenig, Alexander
PMID: 26697077
Journal: Cancer Immunol Res. 2016 Mar;4(3):204-14.
Title: Identification of T-cell Receptors Targeting KRAS-Mutated Human Tumors.
Author: Wang, Qiong J|Yu, Zhiya|Griffith, Kayla|Hanada, Ken-ichi|Restifo, Nicholas P|Yang, James C
PMID: 26701267
Journal: Ann Anat. 2016 Sep;207:2-8.
Title: A bioluminescent mouse model of proliferation to highlight early stages of pancreatic cancer: A suitable tool for preclinical studies.
Author: de Latouliere, Luisa|Manni, Isabella|Iacobini, Carla|Pugliese, Giuseppe|Grazi, Gian Luca|Perri, Pasquale|Cappello, Paola|Novelli, Franco|Menini, Stefano|Piaggio, Giulia
PMID: 26704357
Journal: Cancer Discov. 2016 Mar;6(3):256-69.
Title: Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia.
Author: Lee, Kyoung Eun|Spata, Michelle|Bayne, Lauren J|Buza, Elizabeth L|Durham, Amy C|Allman, David|Vonderheide, Robert H|Simon, M Celeste
PMID: 26715642
Journal: Cancer Discov. 2016 Mar;6(3):247-55.
Title: IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia.
Author: Pylayeva-Gupta, Yuliya|Das, Shipra|Handler, Jesse S|Hajdu, Cristina H|Coffre, Maryaline|Koralov, Sergei B|Bar-Sagi, Dafna
PMID: 26715643
Journal: Oncotarget. 2016 Mar 8;7(10):11424-33.
Title: Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells.
Author: Benitz, Simone|Regel, Ivonne|Reinhard, Tobias|Popp, Anna|Schaffer, Isabell|Raulefs, Susanne|Kong, Bo|Esposito, Irene|Michalski, Christoph W|Kleeff, Jorg
PMID: 26716510
Journal: Oncotarget. 2016 Jan 26;7(4):3984-92.
Title: Simultaneous gene silencing of KRAS and anti-apoptotic genes as a multitarget therapy.
Author: Werner, Kristin|Lademann, Franziska|Thepkaysone, May-Linn|Jahnke, Beatrix|Aust, Daniela E|Kahlert, Christoph|Weber, Georg|Weitz, Jurgen|Grutzmann, Robert|Pilarsky, Christian
PMID: 26716649
Journal: Gene. 2016 Mar 10;578(2):263-73.
Title: Microarray-based gene expression profiling reveals genes and pathways involved in the oncogenic function of REG3A on pancreatic cancer cells.
Author: Xu, Qianqian|Fu, Rong|Yin, Guoxiao|Liu, Xiulan|Liu, Yang|Xiang, Ming
PMID: 26719042
Journal: Cancer Cell. 2016 Jan 11;29(1):75-89.
Title: Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.
Author: Hayes, Tikvah K|Neel, Nicole F|Hu, Chaoxin|Gautam, Prson|Chenard, Melissa|Long, Brian|Aziz, Meraj|Kassner, Michelle|Bryant, Kirsten L|Pierobon, Mariaelena|Marayati, Raoud|Kher, Swapnil|George, Samuel D|Xu, Mai|Wang-Gillam, Andrea|Samatar, Ahmed A|Maitra,
PMID: 26725216
Journal: Mol Oncol. 2016 Apr;10(4):635-43.
Title: Clinical relevance of circulating KRAS mutated DNA in plasma from patients with advanced pancreatic cancer.
Author: Tjensvoll, Kjersti|Lapin, Morten|Buhl, Tove|Oltedal, Satu|Steen-Ottosen Berry, Katrine|Gilje, Bjornar|Soreide, Jon Arne|Javle, Millind|Nordgard, Oddmund|Smaaland, Rune
PMID: 26725968
Journal: Cancer Discov. 2016 Mar;6(3):300-15.
Title: Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120.
Author: Chen, Shih-Hsun|Zhang, Youyan|Van Horn, Robert D|Yin, Tinggui|Buchanan, Sean|Yadav, Vipin|Mochalkin, Igor|Wong, Swee Seong|Yue, Yong Gang|Huber, Lysiane|Conti, Ilaria|Henry, James R|Starling, James J|Plowman, Gregory D|Peng, Sheng-Bin
PMID: 26732095
Journal: Eur J Cancer. 2016 Feb;54:75-83.
Title: Targeting KRAS for diagnosis, prognosis, and treatment of pancreatic cancer: Hopes and realities.
Author: Bournet, Barbara|Buscail, Camille|Muscari, Fabrice|Cordelier, Pierre|Buscail, Louis
PMID: 26735353
Journal: Oncotarget. 2016 Feb 16;7(7):7747-60.
Title: HDAC3 mediates smoking-induced pancreatic cancer.
Author: Edderkaoui, Mouad|Xu, Shiping|Chheda, Chintan|Morvaridi, Susan|Hu, Robert W|Grippo, Paul J|Mascarinas, Emman|Principe, Daniel R|Knudsen, Beatrice|Xue, Jing|Habtezion, Aida|Uyeminami, Dale|Pinkerton, Kent E|Pandol, Stephen J
PMID: 26745602
Journal: Mol Cancer Res. 2016 Mar;14(3):267-77.
Title: Transcriptional Regulation of miR-31 by Oncogenic KRAS Mediates Metastatic Phenotypes by Repressing RASA1.
Author: Kent, Oliver A|Mendell, Joshua T|Rottapel, Robert
PMID: 26747707
Journal: Sci Rep. 2016 Jan 12;6:19222.
Title: Mutant p53 determines pancreatic cancer poor prognosis to pancreatectomy through upregulation of cavin-1 in patients with preoperative serum CA19-9 >/= 1,000 U/mL.
Author: Xiang, Jin-Feng|Wang, Wen-Quan|Liu, Liang|Xu, Hua-Xiang|Wu, Chun-Tao|Yang, Jing-Xuan|Qi, Zi-Hao|Wang, Ya-Qi|Xu, Jin|Liu, Chen|Long, Jiang|Ni, Quan-Xing|Li, Min|Yu, Xian-Jun
PMID: 26753987
Journal: Oncotarget. 2016 Feb 2;7(5):6000-14.
Title: Hypoxia-induced lncRNA-NUTF2P3-001 contributes to tumorigenesis of pancreatic cancer by derepressing the miR-3923/KRAS pathway.
Author: Li, Xiang|Deng, Shi-jiang|Zhu, Shuai|Jin, Yan|Cui, Shi-peng|Chen, Jing-yuan|Xiang, Cheng|Li, Qun-ying|He, Chi|Zhao, Shu-feng|Chen, Heng-yu|Niu, Yi|Liu, Yang|Deng, Shi-chang|Wang, Chun-you|Zhao, Gang
PMID: 26755660
Journal: Gut. 2016 Jun;65(6):1001-14.
Title: Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia.
Author: Demir, Ihsan Ekin|Tieftrunk, Elke|Schorn, Stephan|Saricaoglu, Omer Cemil|Pfitzinger, Paulo L|Teller, Steffen|Wang, Kun|Waldbaur, Christine|Kurkowski, Magdalena U|Wormann, Sonja Maria|Shaw, Victoria E|Kehl, Timo|Laschinger, Melanie|Costello, Eithne|Algul,
PMID: 26762195
Journal: Cancer Genet. 2016 Jan-Feb;209(1-2):42-9.
Title: Digitally guided microdissection aids somatic mutation detection in difficult to dissect tumors.
Author: Geiersbach, Katherine|Adey, Nils|Welker, Noah|Elsberry, Danielle|Malmberg, Elisabeth|Edwards, Sumie|Downs-Kelly, Erinn|Salama, Mohamed|Bronner, Mary
PMID: 26767919
Journal: Oncotarget. 2016 Feb 9;7(6):7280-96.
Title: CXCR2 signaling regulates KRAS(G(1)(2)D)-induced autocrine growth of pancreatic cancer.
Author: Purohit, Abhilasha|Varney, Michelle|Rachagani, Satyanarayana|Ouellette, Michel M|Batra, Surinder K|Singh, Rakesh K
PMID: 26771140
Journal: Bull Cancer. 2016 Jan;103(1):55-65.
Title: [What future for circulating tumor DNA? Current data and prospects in colorectal, non-small cell lung and pancreatic cancers].
Author: Pietrasz, Daniel|Pecuchet, Nicolas|Fabre, Elizabeth|Blons, Helene|Chevalier, Line|Taly, Valerie|Laurent-Puig, Pierre|Bachet, Jean-Baptiste
PMID: 26790710
Journal: Mol Cancer Ther. 2016 Mar;15(3):491-502.
Title: GSK-3beta Governs Inflammation-Induced NFATc2 Signaling Hubs to Promote Pancreatic Cancer Progression.
Author: Baumgart, Sandra|Chen, Nai-Ming|Zhang, Jin-San|Billadeau, Daniel D|Gaisina, Irina N|Kozikowski, Alan P|Singh, Shiv K|Fink, Daniel|Strobel, Philipp|Klindt, Caroline|Zhang, Lizhi|Bamlet, William R|Koenig, Alexander|Hessmann, Elisabeth|Gress, Thomas M|Ellenr
PMID: 26823495
Journal: Lancet. 2016 Jul 2;388(10039):73-85.
Title: Pancreatic cancer.
Author: Kamisawa, Terumi|Wood, Laura D|Itoi, Takao|Takaori, Kyoichi
PMID: 26830752
Journal: ACS Nano. 2016 Feb 23;10(2):2702-15.
Title: Irinotecan Delivery by Lipid-Coated Mesoporous Silica Nanoparticles Shows Improved Efficacy and Safety over Liposomes for Pancreatic Cancer.
Author: Liu, Xiangsheng|Situ, Allen|Kang, Yanan|Villabroza, Katie Rose|Liao, Yupei|Chang, Chong Hyun|Donahue, Timothy|Nel, Andre E|Meng, Huan
PMID: 26835979
Journal: Ann Surg Oncol. 2016 Jun;23(6):1993-2000.
Title: Adjuvant Trametinib Delays the Outgrowth of Occult Pancreatic Cancer in a Mouse Model of Patient-Derived Liver Metastasis.
Author: Newhook, Timothy E|Lindberg, James M|Adair, Sara J|Kim, Alison J|Stelow, Edward B|Rahma, Osama E|Parsons, J Thomas|Bauer, Todd W
PMID: 26847682
Journal: Cancer Res. 2016 Apr 1;76(7):1965-74.
Title: Small-Molecule Inhibition of GCNT3 Disrupts Mucin Biosynthesis and Malignant Cellular Behaviors in Pancreatic Cancer.
Author: Rao, Chinthalapally V|Janakiram, Naveena B|Madka, Venkateshwar|Kumar, Gaurav|Scott, Edgar J|Pathuri, Gopal|Bryant, Taylor|Kutche, Hannah|Zhang, Yuting|Biddick, Laura|Gali, Hariprasad|Zhao, Yan D|Lightfoot, Stan|Mohammed, Altaf
PMID: 26880801
Journal: Sci Rep. 2016 Feb 17;6:21648.
Title: MIA PaCa-2 and PANC-1 - pancreas ductal adenocarcinoma cell lines with neuroendocrine differentiation and somatostatin receptors.
Author: Gradiz, Rui|Silva, Henriqueta C|Carvalho, Lina|Botelho, Maria Filomena|Mota-Pinto, Anabela
PMID: 26884312
Journal: Cas Lek Cesk. 2016;155(1):48-51.
Title: [KRAS mutation assay on EUS-FNA specimens from pacients with pancreatic mass].
Author: Bunganic, Bohus|Halkova, Tereza|Benesova, Lucie|Belsanova, Barbora|Laclav, Martin|Hruzova, Martina|Traboulsi, Eva|Fric, Premysl|Suchanek, Stepan|Minarik, Marek|Zavoral, Miroslav
PMID: 26898792
Journal: Pancreatology. 2016 May-Jun;16(3):372-81.
Title: Telomerase activity in pancreatic juice differentiates pancreatic cancer from chronic pancreatitis: A meta-analysis.
Author: Hata, Tatsuo|Ishida, Masaharu|Motoi, Fuyuhiko|Yamaguchi, Takuhiro|Naitoh, Takeshi|Katayose, Yu|Egawa, Shinichi|Unno, Michiaki
PMID: 26899542
Journal: Nature. 2016 Mar 3;531(7592):47-52.
Title: Genomic analyses identify molecular subtypes of pancreatic cancer.
Author: Bailey, Peter|Chang, David K|Nones, Katia|Johns, Amber L|Patch, Ann-Marie|Gingras, Marie-Claude|Miller, David K|Christ, Angelika N|Bruxner, Tim J C|Quinn, Michael C|Nourse, Craig|Murtaugh, L Charles|Harliwong, Ivon|Idrisoglu, Senel|Manning, Suzanne|Nourba
PMID: 26909576
Journal: Nat Commun. 2016 Feb 26;7:10770.
Title: Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice.
Author: Maresch, Roman|Mueller, Sebastian|Veltkamp, Christian|Ollinger, Rupert|Friedrich, Mathias|Heid, Irina|Steiger, Katja|Weber, Julia|Engleitner, Thomas|Barenboim, Maxim|Klein, Sabine|Louzada, Sandra|Banerjee, Ruby|Strong, Alexander|Stauber, Teresa|Gross, Nin
PMID: 26916719
Journal: Cancer Treat Rev. 2016 Mar;44:17-25.
Title: Changing the course of pancreatic cancer--Focus on recent translational advances.
Author: Javle, Milind|Golan, Talia|Maitra, Anirban
PMID: 26924195
Journal: Med Oncol. 2016 Apr;33(4):32.
Title: KRAS, BRAF, and PIK3CA mutations, and patient prognosis in 126 pancreatic cancers: pyrosequencing technology and literature review.
Author: Zhou, Lei|Baba, Yoshifumi|Kitano, Yuki|Miyake, Keisuke|Zhang, Xiaobo|Yamamura, Kensuke|Kosumi, Keisuke|Kaida, Takayoshi|Arima, Kota|Taki, Katsunobu|Higashi, Takaaki|Imai, Katsunori|Hashimoto, Daisuke|Yamashita, Yoichi|Chikamoto, Akira|Beppu, Toru|Tan, Xia
PMID: 26927447
Journal: Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3078-83.
Title: Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer.
Author: Saloman, Jami L|Albers, Kathryn M|Li, Dongjun|Hartman, Douglas J|Crawford, Howard C|Muha, Emily A|Rhim, Andrew D|Davis, Brian M
PMID: 26929329
Journal: Mol Cancer Ther. 2016 May;15(5):985-97.
Title: Novel Anti-CRR9/CLPTM1L Antibodies with Antitumorigenic Activity Inhibit Cell Surface Accumulation, PI3K Interaction, and Survival Signaling.
Author: Puskas, Laszlo G|Man, Imola|Szebeni, Gabor|Tiszlavicz, Laszlo|Tsai, Susan|James, Michael A
PMID: 26939707
Journal: Gastroenterology. 2016 Jun;150(7):1659-1672.e5.
Title: Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice.
Author: Seifert, Lena|Werba, Gregor|Tiwari, Shaun|Giao Ly, Nancy Ngoc|Nguy, Susanna|Alothman, Sara|Alqunaibit, Dalia|Avanzi, Antonina|Daley, Donnele|Barilla, Rocky|Tippens, Daniel|Torres-Hernandez, Alejandro|Hundeyin, Mautin|Mani, Vishnu R|Hajdu, Cristina|Pellicc
PMID: 26946344
Journal: Cell Rep. 2016 Mar 15;14(10):2325-36.
Title: Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions.
Author: Liou, Geou-Yarh|Doppler, Heike|DelGiorno, Kathleen E|Zhang, Lizhi|Leitges, Michael|Crawford, Howard C|Murphy, Michael P|Storz, Peter
PMID: 26947075
Journal: Pancreas. 2016 Sep;45(8):1111-4.
Title: Heterogeneity of KRAS Mutations in Pancreatic Ductal Adenocarcinoma.
Author: Hashimoto, Daisuke|Arima, Kota|Yokoyama, Naomi|Chikamoto, Akira|Taki, Katsunobu|Inoue, Risa|Kaida, Takayoshi|Higashi, Takaaki|Nitta, Hidetoshi|Ohmuraya, Masaki|Hirota, Masahiko|Beppu, Toru|Baba, Hideo
PMID: 26967456
Journal: J UOEH. 2016 Mar 1;38(1):1-8.
Title: Clinicopathological Implications of Wingless/int1 (WNT) Signaling Pathway in Pancreatic Ductal Adenocarcinoma.
Author: Nakamoto, Mitsuhiro|Hisaoka, Masanori
PMID: 26972939
Journal: Cancer Cell. 2016 Mar 14;29(3):324-338.
Title: KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis.
Author: Wei, Daoyan|Wang, Liang|Yan, Yongmin|Jia, Zhiliang|Gagea, Mihai|Li, Zhiwei|Zuo, Xiangsheng|Kong, Xiangyu|Huang, Suyun|Xie, Keping
PMID: 26977883
Journal: Clin Cancer Res. 2016 Aug 1;22(15):3950-60.
Title: FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer.
Author: Ji, Shunrong|Qin, Yi|Liang, Chen|Huang, Run|Shi, Si|Liu, Jiang|Jin, Kaizhou|Liang, Dingkong|Xu, Wenyan|Zhang, Bo|Liu, Liang|Liu, Chen|Xu, Jin|Ni, Quanxing|Chiao, Paul J|Li, Min|Yu, Xianjun
PMID: 26983463
Journal: Future Oncol. 2016 May;12(9):1135-50.
Title: Developments in miRNA gene signaling pathways in pancreatic cancer.
Author: Vorvis, Christina|Koutsioumpa, Marina|Iliopoulos, Dimitrios
PMID: 26984178
Journal: Neoplasia. 2016 Mar;18(3):172-84.
Title: Prox1-Heterozygosis Sensitizes the Pancreas to Oncogenic Kras-Induced Neoplastic Transformation.
Author: Drosos, Yiannis|Neale, Geoffrey|Ye, Jianming|Paul, Leena|Kuliyev, Emin|Maitra, Anirban|Means, Anna L|Washington, M Kay|Rehg, Jerold|Finkelstein, David B|Sosa-Pineda, Beatriz
PMID: 26992918
Journal: PLoS One. 2016 Mar 21;11(3):e0151654.
Title: Novel Methodology for Rapid Detection of KRAS Mutation Using PNA-LNA Mediated Loop-Mediated Isothermal Amplification.
Author: Itonaga, Masahiro|Matsuzaki, Ibu|Warigaya, Kenji|Tamura, Takaaki|Shimizu, Yuki|Fujimoto, Masakazu|Kojima, Fumiyoshi|Ichinose, Masao|Murata, Shin-Ichi
PMID: 26999437
Journal: Gastroenterology. 2016 Jul;151(1):180-193.e12.
Title: Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival.
Author: Wormann, Sonja M|Song, Liang|Ai, Jiaoyu|Diakopoulos, Kalliope N|Kurkowski, Magdalena U|Gorgulu, Kivanc|Ruess, Dietrich|Campbell, Andrew|Doglioni, Claudio|Jodrell, Duncan|Neesse, Albrecht|Demir, Ihsan E|Karpathaki, Angelica-Phaedra|Barenboim, Maxim|Hageman
PMID: 27003603
Journal: Discov Med. 2016 Feb;21(114):117-23.
Title: Personalized therapy for pancreatic cancer: Do we need better targets, arrows, or both?
Author: O'Hayer, Kevin M|Brody, Jonathan R
PMID: 27011047
Journal: Cancer Res. 2016 Jun 1;76(11):3351-63.
Title: p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia.
Author: Hendley, Audrey M|Wang, Yue J|Polireddy, Kishore|Alsina, Janivette|Ahmed, Ishrat|Lafaro, Kelly J|Zhang, Hao|Roy, Nilotpal|Savidge, Samuel G|Cao, Yanna|Hebrok, Matthias|Maitra, Anirban|Reynolds, Albert B|Goggins, Michael|Younes, Mamoun|Iacobuzio-Donahue, C
PMID: 27032419
Journal: J Gastrointest Oncol. 2016 Apr;7(2):E17-21.
Title: Use of molecular studies for treatment of metastatic pleomorphic large cell pancreatic cancers-a novel strategy.
Author: Padhi, Parikshit|Narula, Arshjyot|Balog, Anna|Christou, Antonios
PMID: 27034802
Journal: J Gastrointest Oncol. 2016 Apr;7(2):E6-E12.
Title: Molecular profiling of a case of advanced pancreatic cancer identifies an active and tolerable combination of targeted therapy with backbone chemotherapy.
Author: Johnson, Benny|Vanderwalde, Ari|Javadi, Nader|Feldman, Rebecca|Reddy, Sandeep Bobby
PMID: 27034805
Journal: Oncotarget. 2016 May 10;7(19):28218-34.
Title: PEDF inhibits pancreatic tumorigenesis by attenuating the fibro-inflammatory reaction.
Author: Principe, Daniel R|DeCant, Brian|Diaz, Andrew M|Mangan, Riley J|Hwang, Rosa|Lowy, Andrew|Shetuni, Brandon B|Sreekumar, Bharath K|Chung, Chuhan|Bentrem, David J|Munshi, Hidayatullah G|Jung, Barbara|Grippo, Paul J|Bishehsari, Faraz
PMID: 27058416
Journal: Cell Stem Cell. 2016 Apr 7;18(4):441-55.
Title: Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis.
Author: Westphalen, C Benedikt|Takemoto, Yoshihiro|Tanaka, Takayuki|Macchini, Marina|Jiang, Zhengyu|Renz, Bernhard W|Chen, Xiaowei|Ormanns, Steffen|Nagar, Karan|Tailor, Yagnesh|May, Randal|Cho, Youngjin|Asfaha, Samuel|Worthley, Daniel L|Hayakawa, Yoku|Urbanska, A
PMID: 27058937
Journal: BMC Cancer. 2016 Apr 11;16:268.
Title: Establishment and characterization of new cell lines of anaplastic pancreatic cancer, which is a rare malignancy: OCUP-A1 and OCUP-A2.
Author: Miura, Kotaro|Kimura, Kenjiro|Amano, Ryosuke|Yamazoe, Sadaaki|Ohira, Go|Murata, Akihiro|Nishio, Kohei|Hasegawa, Tsuyoshi|Yashiro, Masakazu|Nakata, Bunzo|Ohira, Masaichi|Hirakawa, Kosei
PMID: 27067801
Journal: Nat Med. 2016 May;22(5):497-505.
Title: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.
Author: Laklai, Hanane|Miroshnikova, Yekaterina A|Pickup, Michael W|Collisson, Eric A|Kim, Grace E|Barrett, Alex S|Hill, Ryan C|Lakins, Johnathon N|Schlaepfer, David D|Mouw, Janna K|LeBleu, Valerie S|Roy, Nilotpal|Novitskiy, Sergey V|Johansen, Julia S|Poli, Valer
PMID: 27089513
Journal: Nat Commun. 2016 Apr 20;7:11360.
Title: Identification of pyrazolopyridazinones as PDEdelta inhibitors.
Author: Papke, Bjorn|Murarka, Sandip|Vogel, Holger A|Martin-Gago, Pablo|Kovacevic, Marija|Truxius, Dina C|Fansa, Eyad K|Ismail, Shehab|Zimmermann, Gunther|Heinelt, Kaatje|Schultz-Fademrecht, Carsten|Al Saabi, Alaa|Baumann, Matthias|Nussbaumer, Peter|Wittinghofer,
PMID: 27094677
Journal: World J Gastrointest Oncol. 2016 Apr 15;8(4):380-8.
Title: Targeting inflammation in pancreatic cancer: Clinical translation.
Author: Steele, Colin William|Kaur Gill, Nina Angharad|Jamieson, Nigel Balfour|Carter, Christopher Ross
PMID: 27096033
Journal: Cancers (Basel). 2016 Apr 18;8(4). pii: cancers8040045.
Title: KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment.
Author: Zeitouni, Daniel|Pylayeva-Gupta, Yuliya|Der, Channing J|Bryant, Kirsten L
PMID: 27096871
Journal: Mol Med Rep. 2016 Jun;13(6):4943-9.
Title: Critical role of oncogenic KRAS in pancreatic cancer (Review).
Author: Liu, Jiang|Ji, Shunrong|Liang, Chen|Qin, Yi|Jin, Kaizhou|Liang, Dingkon|Xu, Wenyan|Shi, Si|Zhang, Bo|Liu, Liang|Liu, Chen|Xu, Jin|Ni, Quanxing|Yu, Xianjun
PMID: 27121414
Journal: J Clin Pathol. 2016 Apr 27. pii: jclinpath-2016-203696.
Title: Fully automated PCR detection of KRAS mutations on pancreatic endoscopic ultrasound fine-needle aspirates.
Author: de Biase, Dario|de Luca, Caterina|Gragnano, Gianluca|Visani, Michela|Bellevicine, Claudio|Malapelle, Umberto|Tallini, Giovanni|Troncone, Giancarlo
PMID: 27122185
Journal: Cancer Prev Res (Phila). 2016 Jul;9(7):624-34.
Title: Phospho-Aspirin (MDC-22) Prevents Pancreatic Carcinogenesis in Mice.
Author: Mattheolabakis, George|Papayannis, Ioannis|Yang, Jennifer|Vaeth, Brandon M|Wang, Ruixue|Bandovic, Jela|Ouyang, Nengtai|Rigas, Basil|Mackenzie, Gerardo G
PMID: 27138793
Journal: Toxicol Pathol. 2016 Aug;44(6):856-65.
Title: Preclinical Safety Evaluation in Rats of a Polymeric Matrix Containing an siRNA Drug Used as a Local and Prolonged Delivery System for Pancreatic Cancer Therapy.
Author: Ramot, Yuval|Rotkopf, Shay|Gabai, Rachel Malka|Zorde Khvalevsky, Elina|Muravnik, Sofia|Marzoli, Gabriela Alejandra|Domb, Abraham J|Shemi, Amotz|Nyska, Abraham
PMID: 27147553
Journal: Acta Dermatovenerol Croat. 2016 Apr;24(1):70-2.
Title: Adverse Reaction to Cetuximab, an Epidermal Growth Factor Receptor Inhibitor.
Author: Stulhofer Buzina, Daska|Martinac, Ivana|Ledic Drvar, Daniela|Ceovic, Romana|Bilic, Ivan|Marinovic, Branka
PMID: 27149134
Journal: Nat Rev Dis Primers. 2016 Apr 21;2:16022.
Title: Pancreatic cancer.
Author: Kleeff, Jorg|Korc, Murray|Apte, Minoti|La Vecchia, Carlo|Johnson, Colin D|Biankin, Andrew V|Neale, Rachel E|Tempero, Margaret|Tuveson, David A|Hruban, Ralph H|Neoptolemos, John P
PMID: 27158978
Journal: Int J Oncol. 2016 Jul;49(1):164-72.
Title: Role of TFEB-driven autophagy regulation in pancreatic cancer treatment.
Author: Klein, Kathrin|Werner, Kristin|Teske, Christian|Schenk, Miriam|Giese, Thomas|Weitz, Jurgen|Welsch, Thilo
PMID: 27175909
Journal: World J Surg Oncol. 2016 May 16;14:146.
Title: Prognostic significance of K-ras mutations in pancreatic cancer: a meta-analysis.
Author: Tao, Lian-yuan|Zhang, Ling-fu|Xiu, Dian-rong|Yuan, Chun-hui|Ma, Zhao-lai|Jiang, Bin
PMID: 27183870
Journal: Gut. 2016 Nov;65(11):1838-1849.
Title: Tumour-specific delivery of siRNA-coupled superparamagnetic iron oxide nanoparticles, targeted against PLK1, stops progression of pancreatic cancer.
Author: Mahajan, Ujjwal M|Teller, Steffen|Sendler, Matthias|Palankar, Raghavendra|van den Brandt, Cindy|Schwaiger, Theresa|Kuhn, Jens-Peter|Ribback, Silvia|Glockl, Gunnar|Evert, Matthias|Weitschies, Werner|Hosten, Norbert|Dombrowski, Frank|Delcea, Mihaela|Weiss,
PMID: 27196585
Journal: Gastroenterology. 2016 Aug;151(2):338-350.e7.
Title: Administration of Gemcitabine After Pancreatic Tumor Resection in Mice Induces an Antitumor Immune Response Mediated by Natural Killer Cells.
Author: Gurlevik, Engin|Fleischmann-Mundt, Bettina|Brooks, Jennifer|Demir, Ihsan Ekin|Steiger, Katja|Ribback, Silvia|Yevsa, Tetyana|Woller, Norman|Kloos, Arnold|Ostroumov, Dmitrij|Armbrecht, Nina|Manns, Michael P|Dombrowski, Frank|Saborowski, Michael|Kleine, Mori
PMID: 27210037
Journal: Gastroenterology. 2016 Sep;151(3):526-39.
Title: YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling.
Author: Gruber, Ralph|Panayiotou, Richard|Nye, Emma|Spencer-Dene, Bradley|Stamp, Gordon|Behrens, Axel
PMID: 27215660
Journal: Med Oncol. 2016 Jul;33(7):61.
Title: K-Ras mutation detection in liquid biopsy and tumor tissue as prognostic biomarker in patients with pancreatic cancer: a systematic review with meta-analysis.
Author: Li, Tao|Zheng, Yuanting|Sun, Hong|Zhuang, Rongyuan|Liu, Jing|Liu, Tianshu|Cai, Weimin
PMID: 27225938
Journal: Cancer Lett. 2016 Aug 28;379(1):1-11.
Title: Regulation of the Nampt-mediated NAD salvage pathway and its therapeutic implications in pancreatic cancer.
Author: Ju, Huai-Qiang|Zhuang, Zhuo-Nan|Li, Hao|Tian, Tian|Lu, Yun-Xin|Fan, Xiao-Qiang|Zhou, Hai-Jun|Mo, Hai-Yu|Sheng, Hui|Chiao, Paul J|Xu, Rui-Hua
PMID: 27233476
Journal: Curr Protoc Pharmacol. 2016 Jun 1;73:14.39.1-14.39.20.
Title: Genetically Engineered Mouse Models of Pancreatic Cancer: The KPC Model (LSL-Kras(G12D/+) ;LSL-Trp53(R172H/+) ;Pdx-1-Cre), Its Variants, and Their Application in Immuno-oncology Drug Discovery.
Author: Lee, Jae W|Komar, Chad A|Bengsch, Fee|Graham, Kathleen|Beatty, Gregory L
PMID: 27248578
Journal: Br J Surg. 2016 Aug;103(9):1189-99.
Title: Infiltrating immune cells and gene mutations in pancreatic ductal adenocarcinoma.
Author: Wang, W-Q|Liu, L|Xu, H-X|Wu, C-T|Xiang, J-F|Xu, J|Liu, C|Long, J|Ni, Q-X|Yu, X-J
PMID: 27256393
Journal: Clin J Gastroenterol. 2016 Aug;9(4):261-5.
Title: Neuroendocrine carcinoma of the pancreas with similar genetic alterations to invasive ductal adenocarcinoma.
Author: Kimura, Tetsuo|Miyamoto, Hiroshi|Fukuya, Akira|Kitamura, Shinji|Okamoto, Koichi|Kimura, Masako|Muguruma, Naoki|Ikemoto, Tetsuya|Shimada, Mitsuo|Yoneda, Akiko|Bando, Yoshimi|Takishita, Makoto|Takayama, Tetsuji
PMID: 27262570
Journal: Cancer Lett. 2016 Aug 28;379(1):143-53.
Title: Combined targeting of TGF-beta, EGFR and HER2 suppresses lymphangiogenesis and metastasis in a pancreatic cancer model.
Author: Gore, Jesse|Imasuen-Williams, Imade E|Conteh, Abass M|Craven, Kelly E|Cheng, Monica|Korc, Murray
PMID: 27267807
Journal: Br J Cancer. 2016 Jun 28;115(1):59-65.
Title: Prognostic value of circulating tumour DNA in patients undergoing curative resection for pancreatic cancer.
Author: Hadano, Naoto|Murakami, Yoshiaki|Uemura, Kenichiro|Hashimoto, Yasusi|Kondo, Naru|Nakagawa, Naoya|Sueda, Taijiro|Hiyama, Eiso
PMID: 27280632
Journal: Pancreatology. 2016 Jul-Aug;16(4):632-9.
Title: The utility of hyperthermic intra-abdominal chemotherapy with gemcitabine for the inhibition of tumor progression in an experimental model of pancreatic peritoneal carcinomatosis, in relation to their behavior with pancreatic cancer stem cells CD133+ CXCR
Author: Garcia-Santos, Esther Pilar|Padilla-Valverde, David|Villarejo-Campos, Pedro|Murillo-Lazaro, Cristina|Fernandez-Grande, Esther|Palomino-Munoz, Teodoro|Rodriguez-Martinez, Marta|Amo-Salas, Mariano|Nunez-Guerrero, Paloma|Sanchez-Garcia, Susana|Puerto-Puerto,
PMID: 27289344
Journal: J Comp Pathol. 2016 Jul;155(1):24-8.
Title: KRAS Mutations in Canine and Feline Pancreatic Acinar Cell Carcinoma.
Author: Crozier, C|Wood, G A|Foster, R A|Stasi, S|Liu, J H W|Bartlett, J M S|Coomber, B L|Sabine, V S
PMID: 27290644
Journal: Pancreas. 2016 Jul;45(6):915-8.
Title: Tracking the Clonal Evolution of Adenosquamous Carcinoma, a Rare Variant of Intraductal Papillary Mucinous Neoplasm of the Pancreas.
Author: Matsuzaka, Suguru|Karasaki, Hidenori|Ono, Yusuke|Ogata, Munehiko|Oikawa, Kensuke|Tamakawa, Susumu|Chiba, Shin-Ichi|Muraki, Miho|Yokochi, Tomoki|Funakoshi, Hiroshi|Kono, Toru|Nagashima, Kazuo|Mizukami, Yusuke
PMID: 27295533
Journal: Mol Cell Oncol. 2015 Dec 10;3(1):e1035477.
Title: A bright future for protein kinase D1 as a drug target to prevent or treat pancreatic cancer.
Author: Liou, Geou-Yarh|Storz, Peter|Leitges, Michael
PMID: 27308552
Journal: Gastroenterology. 2016 Sep;151(3):540-553.e14.
Title: ETS-Transcription Factor ETV1 Regulates Stromal Expansion and Metastasis in Pancreatic Cancer.
Author: Heeg, Steffen|Das, Koushik K|Reichert, Maximilian|Bakir, Basil|Takano, Shigetsugu|Caspers, Julia|Aiello, Nicole M|Wu, Katherine|Neesse, Albrecht|Maitra, Anirban|Iacobuzio-Donahue, Christine A|Hicks, Philip|Rustgi, Anil K
PMID: 27318148
Journal: Oncotarget. 2016 Jul 12;7(28):44299-44309.
Title: A recombinant chimeric protein specifically induces mutant KRAS degradation and potently inhibits pancreatic tumor growth.
Author: Pan, Ting|Zhang, Yiwen|Zhou, Nan|He, Xin|Chen, Cancan|Liang, Liting|Duan, Xiaobing|Lin, Yingtong|Wu, Kang|Zhang, Hui
PMID: 27322423
Journal: Oncotarget. 2016 Jul 26;7(30):47954-47965.
Title: Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer.
Author: Aguilera, Oscar|Munoz-Sagastibelza, Maria|Torrejon, Blanca|Borrero-Palacios, Aurea|Del Puerto-Nevado, Laura|Martinez-Useros, Javier|Rodriguez-Remirez, Maria|Zazo, Sandra|Garcia, Estela|Fraga, Mario|Rojo, Federico|Garcia-Foncillas, Jesus
PMID: 27323830
Journal: Tumour Biol. 2016 Sep;37(9):12455-12464.
Title: Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells.
Author: Rabi, Thangaiyan|Catapano, Carlo V
PMID: 27333990
Journal: Br J Cancer. 2016 Jul 12;115(2):203-11.
Title: Efficacy of focal adhesion kinase inhibition in non-small cell lung cancer with oncogenically activated MAPK pathways.
Author: Zhang, Hao|Shao, Huanjie|Golubovskaya, Vita M|Chen, Hongbin|Cance, William|Adjei, Alex A|Dy, Grace K
PMID: 27336608
Journal: Nature. 2016 Jun 30;534(7609):647-51.
Title: A combinatorial strategy for treating KRAS-mutant lung cancer.
Author: Manchado, Eusebio|Weissmueller, Susann|Morris, John P 4th|Chen, Chi-Chao|Wullenkord, Ramona|Lujambio, Amaia|de Stanchina, Elisa|Poirier, John T|Gainor, Justin F|Corcoran, Ryan B|Engelman, Jeffrey A|Rudin, Charles M|Rosen, Neal|Lowe, Scott W
PMID: 27338794
Journal: Sci Rep. 2016 Jul 1;6:29133.
Title: Slug inhibits pancreatic cancer initiation by blocking Kras-induced acinar-ductal metaplasia.
Author: Ebine, Kazumi|Chow, Christina R|DeCant, Brian T|Hattaway, Holly Z|Grippo, Paul J|Kumar, Krishan|Munshi, Hidayatullah G
PMID: 27364947
Journal: J Mol Diagn. 2016 Sep;18(5):688-696.
Title: Reality of Single Circulating Tumor Cell Sequencing for Molecular Diagnostics in Pancreatic Cancer.
Author: Court, Colin M|Ankeny, Jacob S|Sho, Shonan|Hou, Shuang|Li, Qingyu|Hsieh, Carolyn|Song, Min|Liao, Xinfang|Rochefort, Matthew M|Wainberg, Zev A|Graeber, Thomas G|Tseng, Hsian-Rong|Tomlinson, James S
PMID: 27375074
Journal: Nat Med. 2016 Aug;22(8):851-60.
Title: Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy.
Author: Jiang, Hong|Hegde, Samarth|Knolhoff, Brett L|Zhu, Yu|Herndon, John M|Meyer, Melissa A|Nywening, Timothy M|Hawkins, William G|Shapiro, Irina M|Weaver, David T|Pachter, Jonathan A|Wang-Gillam, Andrea|DeNardo, David G
PMID: 27376576
Journal: Mol Cancer Ther. 2016 Aug;15(8):1792-8.
Title: Concepts to Target MYC in Pancreatic Cancer.
Author: Wirth, Matthias|Mahboobi, Siavosh|Kramer, Oliver H|Schneider, Gunter
PMID: 27406986
Journal: Cell Death Dis. 2016 Jul 14;7:e2295.
Title: The pancreatitis-associated protein VMP1, a key regulator of inducible autophagy, promotes Kras(G12D)-mediated pancreatic cancer initiation.
Author: Loncle, C|Molejon, M I|Lac, S|Tellechea, J I|Lomberk, G|Gramatica, L|Fernandez Zapico, M F|Dusetti, N|Urrutia, R|Iovanna, J L
PMID: 27415425
Journal: Trends Endocrinol Metab. 2016 Nov;27(11):770-781.
Title: Leveraging Mechanisms Governing Pancreatic Tumorigenesis To Reduce Pancreatic Cancer Mortality.
Author: Donahue, Timothy R|Dawson, David W
PMID: 27461042
Journal: Oncoimmunology. 2016 Mar 16;5(6):e1160184.
Title: Evaluation of innate and adaptive immunity contributing to the antitumor effects of PD1 blockade in an orthotopic murine model of pancreatic cancer.
Author: D'Alincourt Salazar, Marcela|Manuel, Edwin R|Tsai, Weimin|D'Apuzzo, Massimo|Goldstein, Leanne|Blazar, Bruce R|Diamond, Don J
PMID: 27471630
Journal: Cell. 2016 Aug 11;166(4):963-976.
Title: NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer.
Author: Chio, Iok In Christine|Jafarnejad, Seyed Mehdi|Ponz-Sarvise, Mariano|Park, Youngkyu|Rivera, Keith|Palm, Wilhelm|Wilson, John|Sangar, Vineet|Hao, Yuan|Ohlund, Daniel|Wright, Kevin|Filippini, Dea|Lee, Eun Jung|Da Silva, Brandon|Schoepfer, Christina|Wilkinso
PMID: 27477511
Journal: PLoS One. 2016 Aug 5;11(8):e0160658.
Title: Identification of KCa3.1 Channel as a Novel Regulator of Oxidative Phosphorylation in a Subset of Pancreatic Carcinoma Cell Lines.
Author: Kovalenko, Ilya|Glasauer, Andrea|Schockel, Laura|Sauter, Daniel R P|Ehrmann, Alexander|Sohler, Florian|Hagebarth, Andrea|Novak, Ivana|Christian, Sven
PMID: 27494181
Journal: Gastroenterology. 2016 Nov;151(5):1011-1024.e7.
Title: Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver.
Author: Grunwald, Barbara|Harant, Veronika|Schaten, Susanne|Fruhschutz, Monika|Spallek, Ria|Hochst, Bastian|Stutzer, Katharina|Berchtold, Sonja|Erkan, Mert|Prokopchuk, Olga|Martignoni, Marc|Esposito, Irene|Heikenwalder, Mathias|Gupta, Aayush|Siveke, Jens|Saftig,
PMID: 27506299
Journal: BMC Cancer. 2016 Aug 12;16:632.
Title: Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma.
Author: Janky, Rekin's|Binda, Maria Mercedes|Allemeersch, Joke|Van den Broeck, Anke|Govaere, Olivier|Swinnen, Johannes V|Roskams, Tania|Aerts, Stein|Topal, Baki
PMID: 27520560
Journal: Curr Pharm Des. 2016;22(42):6444-6450.
Title: Circulating microRNAs as Potential Diagnostic, Prognostic and Therapeutic Targets in Pancreatic Cancer.
Author: Ebrahimi, Safieh|Hosseini, Mina|Ghasemi, Faezeh|Shahidsales, Soodabeh|Maftouh, Mina|Akbarzade, Hamed|Parizadeh, Seyed Ali Reza|Hassanian, Seyed Mahdi|Avan, Amir
PMID: 27539232
Journal: Mol Cell Biol. 2016 Oct 13;36(21):2742-2754.
Title: Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer.
Author: Zhong, Xiaomin|Zheng, Lan|Shen, Jianfeng|Zhang, Dongmei|Xiong, Minmin|Zhang, Youyou|He, Xinhong|Tanyi, Janos L|Yang, Feng|Montone, Kathleen T|Chen, Xiaojun|Xu, Congjian|Xiang, Andy P|Huang, Qihong|Xu, Xiaowei|Zhang, Lin
PMID: 27550813
Journal: Nat Commun. 2016 Sep 2;7:12685.
Title: Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers.
Author: Muzumdar, Mandar Deepak|Dorans, Kimberly Judith|Chung, Katherine Minjee|Robbins, Rebecca|Tammela, Tuomas|Gocheva, Vasilena|Li, Carman Man-Chung|Jacks, Tyler
PMID: 27585860
Journal: Clin Chem. 2016 Nov;62(11):1482-1491.
Title: Detection of KRAS Mutations in Circulating Tumor DNA by Digital PCR in Early Stages of Pancreatic Cancer.
Author: Brychta, Nora|Krahn, Thomas|von Ahsen, Oliver
PMID: 27591291
Journal: Pharmacol Ther. 2016 Dec;168:29-42.
Title: KRAS-related proteins in pancreatic cancer.
Author: Mann, Karen M|Ying, Haoqiang|Juan, Joseph|Jenkins, Nancy A|Copeland, Neal G
PMID: 27595930
Journal: Oncol Lett. 2016 Sep;12(3):2210-2216.
Title: APC promoter is frequently methylated in pancreatic juice of patients with pancreatic carcinomas or periampullary tumors.
Author: Ginesta, Mireia M|Diaz-Riascos, Zamira Vanessa|Busquets, Juli|Pelaez, Nuria|Serrano, Teresa|Peinado, Miquel Angel|Jorba, Rosa|Garcia-Borobia, Francisco Javier|Capella, Gabriel|Fabregat, Joan
PMID: 27602165
Journal: Science. 2016 Sep 9;353(6304):1161-5.
Title: Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.
Author: Mayers, Jared R|Torrence, Margaret E|Danai, Laura V|Papagiannakopoulos, Thales|Davidson, Shawn M|Bauer, Matthew R|Lau, Allison N|Ji, Brian W|Dixit, Purushottam D|Hosios, Aaron M|Muir, Alexander|Chin, Christopher R|Freinkman, Elizaveta|Jacks, Tyler|Wolpin,
PMID: 27609895
Journal: World J Gastroenterol. 2016 Aug 21;22(31):7046-57.
Title: Therapeutic potential of targeting acinar cell reprogramming in pancreatic cancer.
Author: Wong, Chi-Hin|Li, You-Jia|Chen, Yang-Chao
PMID: 27610015
Journal: Sci Rep. 2016 Sep 14;6:32743.
Title: alpha-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (Kras(G12D), and Kras(G12D)/tp53R270H) mice.
Author: Verma, Raj Kumar|Yu, Wei|Shrivastava, Anju|Shankar, Sharmila|Srivastava, Rakesh K
PMID: 27624879
Journal: Genes Dev. 2016 Sep 1;30(17):1943-55.
Title: Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia.
Author: Liu, Xin|Pitarresi, Jason R|Cuitino, Maria C|Kladney, Raleigh D|Woelke, Sarah A|Sizemore, Gina M|Nayak, Sunayana G|Egriboz, Onur|Schweickert, Patrick G|Yu, Lianbo|Trela, Stefan|Schilling, Daniel J|Halloran, Shannon K|Li, Maokun|Dutta, Shourik|Fernandez, S
PMID: 27633013
Journal: Sci Rep. 2016 Sep 21;6:33758.
Title: The PRKD1 promoter is a target of the KRas-NF-kappaB pathway in pancreatic cancer.
Author: Doppler, Heike|Panayiotou, Richard|Reid, Elizabeth M|Maimo, Willibroad|Bastea, Ligia|Storz, Peter
PMID: 27649783
Journal: Neoplasia. 2016 Sep;18(9):541-52.
Title: Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia.
Author: Pitarresi, Jason R|Liu, Xin|Sharma, Sudarshana M|Cuitino, Maria C|Kladney, Raleigh D|Mace, Thomas A|Donohue, Sydney|Nayak, Sunayana G|Qu, Chunjing|Lee, James|Woelke, Sarah A|Trela, Stefan|LaPak, Kyle|Yu, Lianbo|McElroy, Joseph|Rosol, Thomas J|Shakya, Reen
PMID: 27659014
Journal: Carcinogenesis. 2016 Dec;37(12):1170-1179.
Title: The triterpenoid CDDO-imidazolide reduces immune cell infiltration and cytokine secretion in the KrasG12D;Pdx1-Cre (KC) mouse model of pancreatic cancer.
Author: Leal, Ana S|Sporn, Michael B|Pioli, Patricia A|Liby, Karen T
PMID: 27659181
Journal: Biomed Res Int. 2016;2016:4873089.
Title: Can Molecular Biomarkers Change the Paradigm of Pancreatic Cancer Prognosis?
Author: Martinez-Useros, Javier|Garcia-Foncillas, Jesus
PMID: 27689078
Journal: Oncotarget. 2016 Nov 29;7(48):78827-78840.
Title: KRAS mutations in blood circulating cell-free DNA: a pancreatic cancer case-control.
Author: Le Calvez-Kelm, Florence|Foll, Matthieu|Wozniak, Magdalena B|Delhomme, Tiffany M|Durand, Geoffroy|Chopard, Priscilia|Pertesi, Maroulio|Fabianova, Eleonora|Adamcakova, Zora|Holcatova, Ivana|Foretova, Lenka|Janout, Vladimir|Vallee, Maxime P|Rinaldi, Sabina|
PMID: 27705932
Journal: Nature. 2016 Oct 20;538(7625):378-382.
Title: A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns.
Author: Notta, Faiyaz|Chan-Seng-Yue, Michelle|Lemire, Mathieu|Li, Yilong|Wilson, Gavin W|Connor, Ashton A|Denroche, Robert E|Liang, Sheng-Ben|Brown, Andrew M K|Kim, Jaeseung C|Wang, Tao|Simpson, Jared T|Beck, Timothy|Borgida, Ayelet|Buchner, Nicholas|Chadwick, Di
PMID: 27732578
Journal: Cancer Immunol Res. 2016 Nov;4(11):968-982.
Title: CXCR2-Dependent Accumulation of Tumor-Associated Neutrophils Regulates T-cell Immunity in Pancreatic Ductal Adenocarcinoma.
Author: Chao, Timothy|Furth, Emma E|Vonderheide, Robert H
PMID: 27737879
Journal: Adv Exp Med Biol. 2016;924:13-17.
Title: Clinical Utility of Circulating Tumor DNA for Molecular Assessment and Precision Medicine in Pancreatic Cancer.
Author: Takai, Erina|Totoki, Yasushi|Nakamura, Hiromi|Kato, Mamoru|Shibata, Tatsuhiro|Yachida, Shinichi
PMID: 27753011
Journal: Neoplasia. 2016 Nov;18(11):666-673.
Title: Fbxw7 Deletion Accelerates Kras(G12D)-Driven Pancreatic Tumorigenesis via Yap Accumulation.
Author: Zhang, Qiang|Zhang, Yaqing|Parsels, Joshua D|Lohse, Ines|Lawrence, Theodore S|Pasca di Magliano, Marina|Sun, Yi|Morgan, Meredith A
PMID: 27764699
Journal: Lab Invest. 2016 Dec;96(12):1327-1336.
Title: Quantitative assessment of pancreatic cancer precursor lesions in IHC-stained tissue with a tissue image analysis platform.
Author: Aeffner, Famke|Martin, Nathan T|Peljto, Mirza|Black, Joshua C|Major, Justin K|Jangani, Maryam|Ports, Michael O|Krueger, Joseph S|Young, G David
PMID: 27775692
Journal: Bioorg Med Chem Lett. 2016 Dec 1;26(23):5703-5706.
Title: Novel synthetic chalcones induce apoptosis in the A549 non-small cell lung cancer cells harboring a KRAS mutation.
Author: Wang, Yiqiang|Hedblom, Andreas|Koerner, Steffi K|Li, Mailin|Jernigan, Finith E|Wegiel, Barbara|Sun, Lijun
PMID: 27810244
Journal: Front Oncol. 2016 Oct 26;6:226.
Title: Autophagy Induced during Pancreatitis Promotes KRAS-Dependent Transformation in the Pancreas.
Author: Iovanna, Juan L
PMID: 27833900
Journal: Pathol Int. 2016 Dec;66(12):653-660.
Title: GLI1, a master regulator of the hallmark of pancreatic cancer.
Author: Kasai, Kenji
PMID: 27862693
Journal: Surg Clin North Am. 2016 Dec;96(6):1207-1221.
Title: Genetics of Pancreatic Cancer and Its Implications on Therapy.
Author: Tatarian, Talar|Winter, Jordan M
PMID: 27865273
Journal: Prog Mol Biol Transl Sci. 2016;144:241-275.
Title: Molecular Pathogenesis of Pancreatic Cancer.
Author: Grant, T J|Hua, K|Singh, A
PMID: 27865459
Journal: Neoplasia. 2016 Dec;18(12):765-774.
Title: Suppression of Tumor Growth and Muscle Wasting in a Transgenic Mouse Model of Pancreatic Cancer by the Novel Histone Deacetylase Inhibitor AR-42.
Author: Henderson, Sally E|Ding, Li-Yun|Mo, Xiaokui|Bekaii-Saab, Tanios|Kulp, Samuel K|Chen, Ching-Shih|Huang, Po-Hsien
PMID: 27889645
Journal: Neoplasia. 2016 Dec;18(12):785-794.
Title: Activation of WNT/beta-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61.
Author: Sano, Makoto|Driscoll, David R|DeJesus-Monge, Wilfredo E|Quattrochi, Brian|Appleman, Victoria A|Ou, Jianhong|Zhu, Lihua Julie|Yoshida, Nao|Yamazaki, Shintaro|Takayama, Tadatoshi|Sugitani, Masahiko|Nemoto, Norimichi|Klimstra, David S|Lewis, Brian C
PMID: 27889647
Journal: Gan To Kagaku Ryoho. 2016 Nov;43(11):1326-1331.
Title: [A Novel Treatment Strategy for Pancreatic Cancer Based on Gene Profiles].
Author: Hayashi, Hideyuki|Nishihara, Hiroshi
PMID: 27899773
Journal: Anticancer Res. 2016 Dec;36(12):6347-6356.
Title: Expression Patterns of Growth and Survival Genes with Prognostic Implications in Advanced Pancreatic Cancer.
Author: Pectasides, Dimitrios|Kotoula, Vasiliki|Papaxoinis, George|Alexopoulou, Zoi|Dervenis, Christos|Samantas, Epaminontas|Papaparaskeva, Kleo|Charalambous, Elpida|Gkakou, Chrysoula|Agalianos, Christos|Kalogeras, Konstantine T|Pentheroudakis, George|Fountzilas,
PMID: 27919956
Journal: Sci Rep. 2016 Dec 8;6:38468.
Title: Lipid-modified G4-decoy oligonucleotide anchored to nanoparticles: delivery and bioactivity in pancreatic cancer cells.
Author: Cogoi, S|Jakobsen, U|Pedersen, E B|Vogel, S|Xodo, L E
PMID: 27929127
Journal: Asian Pac J Trop Med. 2016 Dec;9(12):1218-1221.
Title: EUS for pancreatic cystic neoplasms: The roadmap to the future is much more than just a few shades of gray.
Author: Kirtane, Tejas|Bhutani, Manoop S
PMID: 27955751
Journal: Am J Cancer Res. 2016 Dec 1;6(12):2799-2815. eCollection 2016.
Title: A new PDAC mouse model originated from iPSCs-converted pancreatic cancer stem cells (CSCcm).
Author: Calle, Anna Sanchez|Nair, Neha|Oo, Aung KoKo|Prieto-Vila, Marta|Koga, Megumi|Khayrani, Apriliana Cahya|Hussein, Maram|Hurley, Laura|Vaidyanath, Arun|Seno, Akimasa|Iwasaki, Yoshiaki|Calle, Malu|Kasai, Tomonari|Seno, Masaharu
PMID: 28042501
Journal: Oncotarget. 2016 Jul 13;7(34):55437-55448.
Title: Prorenin receptor acts as a potential molecular target for pancreatic ductal adenocarcinoma diagnosis.
Author: Arundhathi, Arivajiagane|Chuang, Wen-Han|Chen, Jen-Kun|Wang, Shin-E|Shyr, Yi-Ming|Chen, Jiun-Yu|Liao, Wei-Neng|Chen, Hsin-Wei|Teng, Yi-Min|Pai, Chiao-Chih|Wang, Chih-Hong
PMID: 28874965
Journal: Gut. 2017 Jul;66(7):1278-1285.
Title: Pharmacological macrophage inhibition decreases metastasis formation in a genetic model of pancreatic cancer.
Author: Griesmann, Heidi|Drexel, Christof|Milosevic, Nada|Sipos, Bence|Rosendahl, Jonas|Gress, Thomas M|Michl, Patrick
PMID: 27013602
Journal: Small GTPases. 2017 Jan 2;8(1):38-42.
Title: KRas, ROS and the initiation of pancreatic cancer.
Author: Storz, Peter
PMID: 27215184
Journal: Anticancer Agents Med Chem. 2017;17(1):115-125.
Title: Induction of Autophagic Cell Death in Apoptosis-resistant Pancreatic Cancer Cells using Benzo[alpha]phenoxazines Derivatives, 10-methyl-benzo[alpha]phenoxazine-5-one and benzo[alpha]phenoxazine-5-one.
Author: Pal, Sanjima|Salunke-Gawalib, Sunita|Konkimallaa, V Badireenath
PMID: 27349450
Journal: Clin Cancer Res. 2017 Jan 1;23(1):137-148.
Title: Tumor-Derived CCL2 Mediates Resistance to Radiotherapy in Pancreatic Ductal Adenocarcinoma.
Author: Kalbasi, Anusha|Komar, Chad|Tooker, Graham M|Liu, Mingen|Lee, Jae W|Gladney, Whitney L|Ben-Josef, Edgar|Beatty, Gregory L
PMID: 27354473
Journal: Gut. 2017 Jan;66(1):124-136.
Title: Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer.
Author: Zhang, Yaqing|Velez-Delgado, Ashley|Mathew, Esha|Li, Dongjun|Mendez, Flor M|Flannagan, Kevin|Rhim, Andrew D|Simeone, Diane M|Beatty, Gregory L|Pasca di Magliano, Marina
PMID: 27402485
Journal: Clin Cancer Res. 2017 Jan 15;23(2):489-502.
Title: IL-21 Enhances Natural Killer Cell Response to Cetuximab-Coated Pancreatic Tumor Cells.
Author: McMichael, Elizabeth L|Jaime-Ramirez, Alena Cristina|Guenterberg, Kristan D|Luedke, Eric|Atwal, Lakhvir S|Campbell, Amanda R|Hu, Zhiwei|Tatum, Armika S|Kondadasula, Sri Vidya|Mo, Xiaokui|Tridandapani, Susheela|Bloomston, Mark|Ellison, E Christopher|Willia
PMID: 27435400
Journal: Oncotarget. 2017 Jun 13;8(24):38276-38293.
Title: Tumor-reducing effect of the clinically used drug clofazimine in a SCID mouse model of pancreatic ductal adenocarcinoma.
Author: Zaccagnino, Angela|Manago, Antonella|Leanza, Luigi|Gontarewitz, Artur|Linder, Bernhard|Azzolini, Michele|Biasutto, Lucia|Zoratti, Mario|Peruzzo, Roberta|Legler, Karen|Trauzold, Anna|Kalthoff, Holger|Szabo, Ildiko
PMID: 27542263
Journal: Pharmacogenomics J. 2017 Oct;17(5):452-460.
Title: Hedgehog pathway overexpression in pancreatic cancer is abrogated by new-generation taxoid SB-T-1216.
Author: Mohelnikova-Duchonova, B|Kocik, M|Duchonova, B|Brynychova, V|Oliverius, M|Hlavsa, J|Honsova, E|Mazanec, J|Kala, Z|Ojima, I|Hughes, D J|Doherty, J E|Murray, H A|Crockard, M A|Lemstrova, R|Soucek, P
PMID: 27573236
Journal: Mol Carcinog. 2017 Mar;56(3):936-944.
Title: The TALE homeodomain transcription factor MEIS1 activates the pro-metastatic melanoma cell adhesion molecule Mcam to promote migration of pancreatic cancer cells.
Author: von Burstin, Johannes|Bachhuber, Friedrich|Paul, Mariel|Schmid, Roland M|Rustgi, Anil K
PMID: 27583552
Journal: Oncotarget. 2017 Jan 24;8(4):5885-5894.
Title: A novel method for RNA extraction from FFPE samples reveals significant differences in biomarker expression between orthotopic and subcutaneous pancreatic cancer patient-derived xenografts.
Author: Hoover, Malachia|Adamian, Yvess|Brown, Mark|Maawy, Ali|Chang, Alexander|Lee, Jacqueline|Gharibi, Armen|Katz, Matthew H|Fleming, Jason|Hoffman, Robert M|Bouvet, Michael|Doebler, Robert|Kelber, Jonathan A
PMID: 27602776
Journal: Clin Cancer Res. 2017 Mar 15;23(6):1607-1620.
Title: Mutant p53 Together with TGFbeta Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer.
Author: Zhong, Yi|Macgregor-Das, Anne|Saunders, Tyler|Whittle, Martin C|Makohon-Moore, Alvin|Kohutek, Zachary A|Poling, Justin|Herbst, Brian T|Javier, Breanna M|Cope, Leslie|Leach, Steven D|Hingorani, Sunil R|Iacobuzio-Donahue, Christine A
PMID: 27637888
Journal: Cancer Lett. 2017 Jan 1;384:86-93.
Title: Mutant allele specific imbalance in oncogenes with copy number alterations: Occurrence, mechanisms, and potential clinical implications.
Author: Yu, Chih-Chieh|Qiu, Wanglong|Juang, Caroline S|Mansukhani, Mahesh M|Halmos, Balazs|Su, Gloria H
PMID: 27725226
Journal: Curr Cancer Drug Targets. 2017;17(1):89-97.
Title: EGFR High Expression, but not KRAS Status, Predicts Sensitivity of Pancreatic Cancer Cells to Nimotuzumab Treatment In Vivo.
Author: Zhou, Chenfei|Zhu, Liangjun|Ji, Jun|Ding, Fangmi|Wang, Chao|Cai, Qu|Yu, Yingyan|Zhu, Zhenggang|Zhang, Jun
PMID: 27739365
Journal: Oncotarget. 2017 Jan 17;8(3):4399-4409.
Title: Targeted delivery of chemotherapy using HSP90 inhibitor drug conjugates is highly active against pancreatic cancer models.
Author: Bobrov, Egor|Skobeleva, Natalia|Restifo, Diana|Beglyarova, Natalya|Cai, Kathy Q|Handorf, Elizabeth|Campbell, Kerry|Proia, David A|Khazak, Vladimir|Golemis, Erica A|Astsaturov, Igor
PMID: 27779106
Journal: Cancer Res. 2017 Jan 1;77(1):100-111.
Title: KRAS/NF-kappaB/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis.
Author: Yuan, Peng|He, Xiao-Hong|Rong, Ye-Fei|Cao, Jing|Li, Yong|Hu, Yun-Ping|Liu, Yingbin|Li, Dangsheng|Lou, Wenhui|Liu, Mo-Fang
PMID: 27793842
Journal: Oncotarget. 2017 Jan 17;8(3):4484-4500.
Title: An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer.
Author: Kent, Oliver A|Sandi, Maria-Jose|Burston, Helen E|Brown, Kevin R|Rottapel, Robert
PMID: 27835861
Journal: Expert Rev Anticancer Ther. 2017 Jan;17(1):19-31.
Title: Targeting reactive oxygen species in development and progression of pancreatic cancer.
Author: Durand, Nisha|Storz, Peter
PMID: 27841037
Journal: Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1389-1398.
Title: Critical role of hnRNP A1 in activating KRAS transcription in pancreatic cancer cells: A molecular mechanism involving G4 DNA.
Author: Cogoi, Susanna|Rapozzi, Valentina|Cauci, Sabina|Xodo, Luigi E
PMID: 27888145
Journal: Oncogene. 2017 Apr 20;36(16):2202-2214.
Title: TGFbeta promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1.
Author: Huang, P-H|Lu, P-J|Ding, L-Y|Chu, P-C|Hsu, W-Y|Chen, C-S|Tsao, C-C|Chen, B-H|Lee, C-T|Shan, Y-S|Chen, C-S
PMID: 27893715
Journal: Oncogene. 2017 Jun 1;36(22):3094-3103.
Title: ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation.
Author: Dumartin, L|Alrawashdeh, W|Trabulo, S M|Radon, T P|Steiger, K|Feakins, R M|di Magliano, M P|Heeschen, C|Esposito, I|Lemoine, N R|Crnogorac-Jurcevic, T
PMID: 27941872
Journal: Target Oncol. 2017 Feb;12(1):97-109.
Title: Phase I/II Study of Refametinib (BAY 86-9766) in Combination with Gemcitabine in Advanced Pancreatic cancer.
Author: Van Laethem, Jean-Luc|Riess, Hanno|Jassem, Jacek|Haas, Michael|Martens, Uwe M|Weekes, Colin|Peeters, Marc|Ross, Paul|Bridgewater, John|Melichar, Bohuslav|Cascinu, Stefano|Saramak, Piotr|Michl, Patrick|Van Brummelen, David|Zaniboni, Alberto|Schmiegel, Woll
PMID: 27975152
Journal: JAMA Oncol. 2017 Apr 1;3(4):516-522.
Title: Effect of Selumetinib and MK-2206 vs Oxaliplatin and Fluorouracil in Patients With Metastatic Pancreatic Cancer After Prior Therapy: SWOG S1115 Study Randomized Clinical Trial.
Author: Chung, Vincent|McDonough, Shannon|Philip, Philip A|Cardin, Dana|Wang-Gillam, Andrea|Hui, Laifong|Tejani, Mohamedtaki A|Seery, Tara E|Dy, Irene A|Al Baghdadi, Tareq|Hendifar, Andrew E|Doyle, L Austin|Lowy, Andrew M|Guthrie, Katherine A|Blanke, Charles D|Ho
PMID: 27978579
Journal: Cancer Lett. 2017 Mar 1;388:303-311.
Title: ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.
Author: Liang, Chen|Qin, Yi|Zhang, Bo|Ji, Shunrong|Shi, Si|Xu, Wenyan|Liu, Jiang|Xiang, Jinfeng|Liang, Dingkong|Hu, Qiangsheng|Ni, Quanxing|Yu, Xianjun|Xu, Jin
PMID: 28025100
Journal: EMBO Mol Med. 2017 Feb;9(2):198-218.
Title: ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth.
Author: Rath, Nicola|Morton, Jennifer P|Julian, Linda|Helbig, Lena|Kadir, Shereen|McGhee, Ewan J|Anderson, Kurt I|Kalna, Gabriela|Mullin, Margaret|Pinho, Andreia V|Rooman, Ilse|Samuel, Michael S|Olson, Michael F
PMID: 28031255
Journal: Oncotarget. 2017 Jan 31;8(5):7691-7709.
Title: Elevation of beta-galactoside alpha2,6-sialyltransferase 1 in a fructoseresponsive manner promotes pancreatic cancer metastasis.
Author: Hsieh, Chi-Che|Shyr, Yi-Ming|Liao, Wen-Ying|Chen, Tien-Hua|Wang, Shin-E|Lu, Peir-Chuen|Lin, Pei-Yu|Chen, Yan-Bo|Mao, Wan-Yu|Han, Hsin-Ying|Hsiao, Michael|Yang, Wen-Bin|Li, Wen-Shan|Sher, Yuh-Pyng|Shen, Chia-Ning
PMID: 28032597
Journal: Pancreas. 2017 Feb;46(2):268-275.
Title: Gemcitabine Enhances Kras-MEK-Induced Matrix Metalloproteinase-10 Expression Via Histone Acetylation in Gemcitabine-Resistant Pancreatic Tumor-initiating Cells.
Author: Shimizu, Kazuya|Nishiyama, Takaaki|Hori, Yuichi
PMID: 28060183
Journal: Cancer Res. 2017 Jan 15;77(2):320-329.
Title: IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis.
Author: Rajurkar, Mihir|Dang, Kyvan|Fernandez-Barrena, Maite G|Liu, Xiangfan|Fernandez-Zapico, Martin E|Lewis, Brian C|Mao, Junhao
PMID: 28069799
Journal: Pharmacol Res. 2017 Mar;117:370-376.
Title: Pharmacological strategies to target oncogenic KRAS signaling in pancreatic cancer.
Author: Chuang, Hsiao-Ching|Huang, Po-Hsien|Kulp, Samuel K|Chen, Ching-Shih
PMID: 28077300
Journal: Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1129-1134.
Title: Stromal cues regulate the pancreatic cancer epigenome and metabolome.
Author: Sherman, Mara H|Yu, Ruth T|Tseng, Tiffany W|Sousa, Cristovao M|Liu, Sihao|Truitt, Morgan L|He, Nanhai|Ding, Ning|Liddle, Christopher|Atkins, Annette R|Leblanc, Mathias|Collisson, Eric A|Asara, John M|Kimmelman, Alec C|Downes, Michael|Evans, Ronald M
PMID: 28096419
Journal: Pancreas. 2017 Mar;46(3):335-340.
Title: Utility of Assessing the Number of Mutated KRAS, CDKN2A, TP53, and SMAD4 Genes Using a Targeted Deep Sequencing Assay as a Prognostic Biomarker for Pancreatic Cancer.
Author: Hayashi, Hideyuki|Kohno, Takashi|Ueno, Hideki|Hiraoka, Nobuyoshi|Kondo, Shunsuke|Saito, Motonobu|Shimada, Yoko|Ichikawa, Hitoshi|Kato, Mamoru|Shibata, Tatsuhiro|Morizane, Chigusa|Sakamoto, Yasunari|Shimada, Kazuaki|Komatsu, Yoshito|Sakamoto, Naoya|Okusaka
PMID: 28099251
Journal: Ann Oncol. 2017 Apr 1;28(4):741-747.
Title: High prevalence of mutant KRAS in circulating exosome-derived DNA from early-stage pancreatic cancer patients.
Author: Allenson, K|Castillo, J|San Lucas, F A|Scelo, G|Kim, D U|Bernard, V|Davis, G|Kumar, T|Katz, M|Overman, M J|Foretova, L|Fabianova, E|Holcatova, I|Janout, V|Meric-Bernstam, F|Gascoyne, P|Wistuba, I|Varadhachary, G|Brennan, P|Hanash, S|Li, D|Maitra, A|Alvare
PMID: 28104621
Journal: Mol Cancer Res. 2017 Feb;15(2):201-212.
Title: Oncogenic KRAS Targets MUC16/CA125 in Pancreatic Ductal Adenocarcinoma.
Author: Liang, Chen|Qin, Yi|Zhang, Bo|Ji, Shunrong|Shi, Si|Xu, Wenyan|Liu, Jiang|Xiang, Jinfeng|Liang, Dingkong|Hu, Qiangsheng|Ni, Quanxing|Xu, Jin|Yu, Xianjun
PMID: 28108627
Journal: Cancer Biol Ther. 2017 Mar 4;18(3):158-165.
Title: Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer.
Author: Yang, Sujuan|Che, Sara P Y|Kurywchak, Paul|Tavormina, Jena L|Gansmo, Liv B|Correa de Sampaio, Pedro|Tachezy, Michael|Bockhorn, Maximilian|Gebauer, Florian|Haltom, Amanda R|Melo, Sonia A|LeBleu, Valerie S|Kalluri, Raghu
PMID: 28121262
Journal: Eur Rev Med Pharmacol Sci. 2017 Jan;21(1):48-54.
Title: PKR2 and beta-catenin genes regulates pancreatic cancer chemosensitivity.
Author: Zhong, R-L|Li, Y|Fang, Z|Fang, K-F|Wang, L
PMID: 28121357
Journal: Hum Gene Ther Methods. 2017 Feb;28(1):49-59.
Title: Efficient Gene Delivery and Expression in Pancreas and Pancreatic Tumors by Capsid-Optimized AAV8 Vectors.
Author: Chen, Min|Maeng, Kyungah|Nawab, Akbar|Francois, Rony A|Bray, Julie K|Reinhard, Mary K|Boye, Sanford L|Hauswirth, William W|Kaye, Frederic J|Aslanidi, Georgiy|Srivastava, Arun|Zajac-Kaye, Maria
PMID: 28125909
Journal: Pancreatology. 2017 Mar - Apr;17(2):285-290.
Title: Utility of serum DNA as a marker for KRAS mutations in pancreatic cancer tissue.
Author: Ako, Soichiro|Nouso, Kazuhiro|Kinugasa, Hideaki|Dohi, Chihiro|Matushita, Hiroshi|Mizukawa, Sho|Muro, Shinichiro|Akimoto, Yutaka|Uchida, Daisuke|Tomoda, Takeshi|Matsumoto, Kazuyuki|Horiguchi, Shigeru|Tsutsumi, Koichiro|Kato, Hironari|Okada, Hiroyuki
PMID: 28139399
Journal: PLoS Med. 2017 Jan 31;14(1):e1002223.
Title: Master Regulators of Oncogenic KRAS Response in Pancreatic Cancer: An Integrative Network Biology Analysis.
Author: Sivakumar, Shivan|de Santiago, Ines|Chlon, Leon|Markowetz, Florian
PMID: 28141826
Journal: Cell Oncol (Dordr). 2017 Apr;40(2):167-180.
Title: Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells.
Author: Gilardini Montani, Maria Saveria|Granato, Marisa|Santoni, Claudio|Del Porto, Paola|Merendino, Nicolo|D'Orazi, Gabriella|Faggioni, Alberto|Cirone, Mara
PMID: 28160167
Journal: Nature. 2017 Feb 16;542(7641):362-366.
Title: Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.
Author: Genovese, Giannicola|Carugo, Alessandro|Tepper, James|Robinson, Frederick Scott|Li, Liren|Svelto, Maria|Nezi, Luigi|Corti, Denise|Minelli, Rosalba|Pettazzoni, Piergiorgio|Gutschner, Tony|Wu, Chia-Chin|Seth, Sahil|Akdemir, Kadir Caner|Leo, Elisabetta|Amin,
PMID: 28178232
Journal: Cell Rep. 2017 Feb 7;18(6):1543-1557.
Title: ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition.
Author: Wang, Belinda|Krall, Elsa Beyer|Aguirre, Andrew James|Kim, Miju|Widlund, Hans Ragnar|Doshi, Mihir Bhavik|Sicinska, Ewa|Sulahian, Rita|Goodale, Amy|Cowley, Glenn Spencer|Piccioni, Federica|Doench, John Gerard|Root, David Edward|Hahn, William Chun
PMID: 28178529
Journal: Dig Endosc. 2017 Sep;29(6):657-666.
Title: Team work and cytopathology molecular diagnosis of solid pancreatic lesions.
Author: Fabbri, Carlo|Gibiino, Giulia|Fornelli, Adele|Cennamo, Vincenzo|Grifoni, Daniela|Visani, Michela|Acquaviva, Giorgia|Fassan, Matteo|Fiorino, Sirio|Giovanelli, Silvia|Bassi, Marco|Ghersi, Stefania|Tallini, Giovanni|Jovine, Elio|Gasbarrini, Antonio|de Biase,
PMID: 28190274
Journal: JCI Insight. 2017 Feb 9;2(3):e88032.
Title: BET inhibitors block pancreatic stellate cell collagen I production and attenuate fibrosis in vivo.
Author: Kumar, Krishan|DeCant, Brian T|Grippo, Paul J|Hwang, Rosa F|Bentrem, David J|Ebine, Kazumi|Munshi, Hidayatullah G
PMID: 28194432
Journal: Pancreas. 2017 May/Jun;46(5):614-618.
Title: Methylation of Tumor Suppressor Genes in Autoimmune Pancreatitis.
Author: Kinugawa, Yasuhiro|Uehara, Takeshi|Sano, Kenji|Matsuda, Kazuyuki|Maruyama, Yasuhiro|Kobayashi, Yukihiro|Nakajima, Tomoyuki|Hamano, Hideaki|Kawa, Shigeyuki|Higuchi, Kayoko|Hosaka, Noriko|Shiozawa, Satoshi|Ishigame, Hiroki|Ota, Hiroyoshi
PMID: 28196014
Journal: Int J Cancer. 2017 May 15;140(10):2331-2343.
Title: Endoscopic ultrasound-guided fine-needle aspirate-derived preclinical pancreatic cancer models reveal panitumumab sensitivity in KRAS wild-type tumors.
Author: Berry, William|Algar, Elizabeth|Kumar, Beena|Desmond, Christopher|Swan, Michael|Jenkins, Brendan J|Croagh, Daniel
PMID: 28198009
Journal: Nat Commun. 2017 Feb 21;8:14294.
Title: An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer.
Author: Vallejo, Adrian|Perurena, Naiara|Guruceaga, Elisabet|Mazur, Pawel K|Martinez-Canarias, Susana|Zandueta, Carolina|Valencia, Karmele|Arricibita, Andrea|Gwinn, Dana|Sayles, Leanne C|Chuang, Chen-Hua|Guembe, Laura|Bailey, Peter|Chang, David K|Biankin, Andrew|
PMID: 28220783
Journal: Cell Rep. 2017 Feb 28;18(9):2243-2255.
Title: Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers.
Author: Rajbhandari, Nirakar|Lin, Wan-Chi|Wehde, Barbara L|Triplett, Aleata A|Wagner, Kay-Uwe
PMID: 28249168
Journal: Nat Commun. 2017 Mar 8;8:14686.
Title: Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells.
Author: Lee, Jonghyeob|Snyder, Emily R|Liu, Yinghua|Gu, Xueying|Wang, Jing|Flowers, Brittany M|Kim, Yoo Jung|Park, Sangbin|Szot, Gregory L|Hruban, Ralph H|Longacre, Teri A|Kim, Seung K
PMID: 28272465
Journal: J Gastrointest Oncol. 2017 Feb;8(1):164-172.
Title: Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis.
Author: Borazanci, Erkut|Millis, Sherri Z|Kimbrough, Jeffery|Doll, Nancy|Von Hoff, Daniel|Ramanathan, Ramesh K
PMID: 28280620
Journal: Gastroenterology. 2017 Jul;153(1):277-291.e19.
Title: Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells Under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice.
Author: Jiang, Shu-Heng|Li, Jun|Dong, Fang-Yuan|Yang, Jian-Yu|Liu, De-Jun|Yang, Xiao-Mei|Wang, Ya-Hui|Yang, Min-Wei|Fu, Xue-Liang|Zhang, Xiao-Xin|Li, Qing|Pang, Xiu-Feng|Huo, Yan-Miao|Li, Jiao|Zhang, Jun-Feng|Lee, Ho-Young|Lee, Su-Jae|Qin, Wen-Xin|Gu, Jian-Ren|Su
PMID: 28315323
Journal: Cytojournal. 2017 Feb 24;14:5.
Title: KRAS detection on archival cytological smears by the novel fully automated polymerase chain reaction-based Idylla mutation test.
Author: De Luca, Caterina|Vigliar, Elena|d'Anna, Melania|Pisapia, Pasquale|Bellevicine, Claudio|Malapelle, Umberto|Troncone, Giancarlo
PMID: 28331530
Journal: Semin Cancer Biol. 2017 Jun;44:153-169.
Title: Key biological processes driving metastatic spread of pancreatic cancer as identified by multi-omics studies.
Author: Le Large, T Y S|Bijlsma, M F|Kazemier, G|van Laarhoven, H W M|Giovannetti, E|Jimenez, C R
PMID: 28366542
Journal: Med Sci (Paris). 2017 Mar;33(3):335-339.
Title: [Autophagy contributes to the initiation of pancreatic cancer].
Author: Iovanna, Juan L
PMID: 28367822
Journal: Clin Cancer Res. 2017 Apr 1;23(7):1629-1637.
Title: Pancreatic Cancer: "A Riddle Wrapped in a Mystery inside an Enigma".
Author: Borazanci, Erkut|Dang, Chi V|Robey, Robert W|Bates, Susan E|Chabot, John A|Von Hoff, Daniel D
PMID: 28373361
Journal: Mol Cancer Ther. 2017 Aug;16(8):1445-1455.
Title: U1 Adaptors Suppress the KRAS-MYC Oncogenic Axis in Human Pancreatic Cancer Xenografts.
Author: Tsang, Ashley T|Dudgeon, Crissy|Yi, Lan|Yu, Xin|Goraczniak, Rafal|Donohue, Kristen|Kogan, Samuel|Brenneman, Mark A|Ho, Eric S|Gunderson, Samuel I|Carpizo, Darren R
PMID: 28377488
Journal: Pharm Res. 2017 Jul;34(7):1339-1363.
Title: The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market.
Author: Titze-de-Almeida, Ricardo|David, Catherine|Titze-de-Almeida, Simoneide Souza
PMID: 28389707
Journal: J Clin Invest. 2017 May 1;127(5):2007-2018.
Title: Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer.
Author: Liu, Xiangsheng|Lin, Paulina|Perrett, Ian|Lin, Joshua|Liao, Yu-Pei|Chang, Chong Hyun|Jiang, Jinhong|Wu, Nanping|Donahue, Timothy|Wainberg, Zev|Nel, Andre E|Meng, Huan
PMID: 28414297
Journal: Nat Cell Biol. 2017 May;19(5):518-529.
Title: The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer.
Author: Krebs, Angela M|Mitschke, Julia|Lasierra Losada, Maria|Schmalhofer, Otto|Boerries, Melanie|Busch, Hauke|Boettcher, Martin|Mougiakakos, Dimitrios|Reichardt, Wilfried|Bronsert, Peter|Brunton, Valerie G|Pilarsky, Christian|Winkler, Thomas H|Brabletz, Simone|
PMID: 28414315
Journal: Oncogenesis. 2017 Apr 17;6(4):e319.
Title: Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells.
Author: Kumar, S|Peng, X|Daley, J|Yang, L|Shen, J|Nguyen, N|Bae, G|Niu, H|Peng, Y|Hsieh, H-J|Wang, L|Rao, C|Stephan, C C|Sung, P|Ira, G|Peng, G
PMID: 28414320
Journal: Oncotarget. 2017 May 30;8(22):35902-35918.
Title: MicroRNAs of the mir-17~92 cluster regulate multiple aspects of pancreatic tumor development and progression.
Author: Quattrochi, Brian|Gulvady, Anushree|Driscoll, David R|Sano, Makoto|Klimstra, David S|Turner, Christopher E|Lewis, Brian C
PMID: 28415794
Journal: Immunology. 2017 Sep;152(1):36-51.
Title: Loss of natural killer T cells promotes pancreatic cancer in LSL-Kras(G12D/+) mice.
Author: Janakiram, Naveena B|Mohammed, Altaf|Bryant, Taylor|Ritchie, Rebekah|Stratton, Nicole|Jackson, Lydgia|Lightfoot, Stan|Benbrook, Doris M|Asch, Adam S|Lang, Mark L|Rao, Chinthalapally V
PMID: 28419443
Journal: Cancer Cell Int. 2017 Apr 20;17:47.
Title: Establishment and characterization of 6 novel patient-derived primary pancreatic ductal adenocarcinoma cell lines from Korean pancreatic cancer patients.
Author: Kim, Mi-Ju|Kim, Min-Sun|Kim, Sung Joo|An, Soyeon|Park, Jin|Park, Hosub|Lee, Jae Hoon|Song, Ki-Byung|Hwang, Dae Wook|Chang, Suhwan|Kim, Kyu-Pyo|Jeong, Seong-Yun|Kim, Song Cheol|Hong, Seung-Mo
PMID: 28435405
Journal: Theranostics. 2017 Feb 27;7(5):1133-1148.
Title: SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer.
Author: Yin, Feng|Hu, Kuan|Chen, Yangzi|Yu, Mengying|Wang, Dongyuan|Wang, Qianqian|Yong, Ken-Tye|Lu, Fei|Liang, Yongye|Li, Zigang
PMID: 28435453
Journal: Front Physiol. 2017 Apr 12;8:217.
Title: Computational Model Predicts the Effects of Targeting Cellular Metabolism in Pancreatic Cancer.
Author: Roy, Mahua|Finley, Stacey D
PMID: 28446878
Journal: Br J Cancer. 2017 May 23;116(11):1462-1469.
Title: Extended RAS analysis and correlation with overall survival in advanced pancreatic cancer.
Author: Haas, Michael|Ormanns, Steffen|Baechmann, Sibylle|Remold, Anna|Kruger, Stephan|Westphalen, Christoph B|Siveke, Jens T|Wenzel, Patrick|Schlitter, Anna Melissa|Esposito, Irene|Quietzsch, Detlef|Clemens, Michael R|Kettner, Erika|Laubender, Ruediger P|Jung, A
PMID: 28449008
Journal: Pathology. 2017 Jun;49(4):379-386.
Title: KRAS mutation testing on all non-malignant diagnosis of pancreatic endoscopic ultrasound-guided fine-needle aspiration biopsies improves diagnostic accuracy.
Author: Trisolini, Elena|Armellini, Elia|Paganotti, Alessia|Veggiani, Claudia|Bozzola, Cristina|Frattini, Milo|Pizio, Corinna|Mancuso, Giuseppe|Andorno, Silvano|Boldorini, Renzo
PMID: 28450086
Journal: Cancers (Basel). 2017 Apr 28;9(5). pii: cancers9050042.
Title: KRAS, TP53, CDKN2A, SMAD4, BRCA1, and BRCA2 Mutations in Pancreatic Cancer.
Author: Cicenas, Jonas|Kvederaviciute, Kotryna|Meskinyte, Ingrida|Meskinyte-Kausiliene, Edita|Skeberdyte, Aiste|Cicenas, Jonas
PMID: 28452926
Journal: Oncol Lett. 2017 Mar;13(3):1939-1943.
Title: Effect of cigarette smoke exposure and mutant Kras overexpression on pancreatic cell proliferation.
Author: Glauert, Howard P|Elliott, R Scott|Han, Sung Gu|Athey, Mark|Lee, Eun Y|Gairola, C Gary
PMID: 28454347
Journal: Clin Cancer Res. 2017 Aug 15;23(16):4625-4632.
Title: Rb Loss and KRAS Mutation Are Predictors of the Response to Platinum-Based Chemotherapy in Pancreatic Neuroendocrine Neoplasm with Grade 3: A Japanese Multicenter Pancreatic NEN-G3 Study.
Author: Hijioka, Susumu|Hosoda, Waki|Matsuo, Keitaro|Ueno, Makoto|Furukawa, Masayuki|Yoshitomi, Hideyuki|Kobayashi, Noritoshi|Ikeda, Masafumi|Ito, Tetsuhide|Nakamori, Shoji|Ishii, Hiroshi|Kodama, Yuzo|Morizane, Chigusa|Okusaka, Takuji|Yanagimoto, Hiroaki|Notohara
PMID: 28455360
Journal: Cancer Treat Rev. 2017 May;56:28-35.
Title: Unraveling molecular pathways of poorly differentiated neuroendocrine carcinomas of the gastroenteropancreatic system: A systematic review.
Author: Girardi, Daniel M|Silva, Andrea C B|Rego, Juliana Florinda M|Coudry, Renata A|Riechelmann, Rachel P
PMID: 28456055
Journal: PLoS One. 2017 May 5;12(5):e0176844.
Title: LSL-KrasG12D; LSL-Trp53R172H/+; Ink4flox/+; Ptf1/p48-Cre mice are an applicable model for locally invasive and metastatic pancreatic cancer.
Author: Ma, Lixiang|Saiyin, Hexige
PMID: 28475592
Journal: Am J Transplant. 2017 Oct;17(10):2720-2727.
Title: Modeling the Iatrogenic Pancreatic Cancer Risk After Islet Autotransplantation in Mouse.
Author: Dugnani, E|Pasquale, V|Liberati, D|Citro, A|Cantarelli, E|Pellegrini, S|Marra, P|Canu, T|Balzano, G|Scavini, M|Esposito, A|Doglioni, C|Piemonti, L
PMID: 28510280
Journal: Cell Rep. 2017 May 16;19(7):1322-1333.
Title: The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesions Alters Macrophage Populations and Mediates Pancreatic Tumorigenesis.
Author: Liou, Geou-Yarh|Bastea, Ligia|Fleming, Alicia|Doppler, Heike|Edenfield, Brandy H|Dawson, David W|Zhang, Lizhi|Bardeesy, Nabeel|Storz, Peter
PMID: 28514653
Journal: Eur J Pharm Sci. 2017 Dec 15;110:62-69.
Title: Anti-tumor effects of a 'human & mouse cross-reactive' anti-ADAM17 antibody in a pancreatic cancer model in vivo.
Author: Ye, Jie|Yuen, Shun Ming|Murphy, Gillian|Xie, Ruiyu|Kwok, Hang Fai
PMID: 28554668
Journal: Oncotarget. 2017 Jul 4;8(27):44295-44311.
Title: Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer.
Author: Ning, Changwen|Liang, Min|Liu, Shuang|Wang, Guan|Edwards, Holly|Xia, Yang|Polin, Lisa|Dyson, Gregory|Taub, Jeffrey W|Mohammad, Ramzi M|Azmi, Asfar S|Zhao, Lijing|Ge, Yubin
PMID: 28574828
Journal: Cancer Lett. 2017 Aug 28;402:61-70.
Title: A combinatorial strategy using YAP and pan-RAF inhibitors for treating KRAS-mutant pancreatic cancer.
Author: Zhao, Xiao|Wang, Xiuchao|Fang, Lijun|Lan, Chungen|Zheng, Xiaowei|Wang, Yongwei|Zhang, Yinlong|Han, Xuexiang|Liu, Shaoli|Cheng, Keman|Zhao, Ying|Shi, Jian|Guo, Jiayi|Hao, Jihui|Ren, He|Nie, Guangjun
PMID: 28576749
Journal: Oncogene. 2017 Oct 5;36(40):5639-5647.
Title: Pancreatic cancer heterogeneity and response to Mek inhibition.
Author: Pedersen, K|Bilal, F|Bernado Morales, C|Salcedo, M T|Macarulla, T|Masso-Valles, D|Mohan, V|Vivancos, A|Carreras, M-J|Serres, X|Abu-Suboh, M|Balsells, J|Allende, E|Sagi, I|Soucek, L|Tabernero, J|Arribas, J
PMID: 28581516
Journal: Oncogene. 2017 Oct 5;36(40):5576-5592.
Title: Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species.
Author: Manent, J|Banerjee, S|de Matos Simoes, R|Zoranovic, T|Mitsiades, C|Penninger, J M|Simpson, K J|Humbert, P O|Richardson, H E
PMID: 28581519
Journal: Oncogene. 2017 Sep 28;36(39):5532-5543.
Title: KLF10 loss in the pancreas provokes activation of SDF-1 and induces distant metastases of pancreatic ductal adenocarcinoma in the Kras(G12D) p53(flox/flox) model.
Author: Weng, C-C|Hawse, J R|Subramaniam, M|Chang, V H S|Yu, W C Y|Hung, W-C|Chen, L-T|Cheng, K-H
PMID: 28581520
Journal: Oncotarget. 2017 Jul 4;8(27):44669-44681.
Title: BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity.
Author: Saiyin, Hexige|Na, Ning|Han, Xu|Fang, Yuan|Wu, Yanhua|Lou, Wenhui|Yang, Xianmei
PMID: 28591720
Journal: Nature. 2017 Jun 22;546(7659):498-503.
Title: Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer.
Author: Kamerkar, Sushrut|LeBleu, Valerie S|Sugimoto, Hikaru|Yang, Sujuan|Ruivo, Carolina F|Melo, Sonia A|Lee, J Jack|Kalluri, Raghu
PMID: 28607485
Journal: Clin Cancer Res. 2017 Sep 15;23(18):5639-5647.
Title: Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin.
Author: Rajeshkumar, N V|Yabuuchi, Shinichi|Pai, Shweta G|De Oliveira, Elizabeth|Kamphorst, Jurre J|Rabinowitz, Joshua D|Tejero, Hector|Al-Shahrour, Fatima|Hidalgo, Manuel|Maitra, Anirban|Dang, Chi V
PMID: 28611197
Journal: Mol Cell Oncol. 2017 Apr 5;4(3):e1314239.
Title: All for one and FOSL1 for all: FOSL1 at the crossroads of lung and pancreatic cancer driven by mutant KRAS.
Author: Vallejo, Adrian|Valencia, Karmele|Vicent, Silvestre
PMID: 28616588
Journal: Mol Cancer Ther. 2017 Sep;16(9):1729-1738.
Title: Cotargeting of MEK and PDGFR/STAT3 Pathways to Treat Pancreatic Ductal Adenocarcinoma.
Author: Sahu, Nisebita|Chan, Emily|Chu, Felix|Pham, Thinh|Koeppen, Hartmut|Forrest, William|Merchant, Mark|Settleman, Jeff
PMID: 28619758
Journal: Adv Exp Med Biol. 2017;983:173-188.
Title: Treatment of Pancreatic Cancer by Aptamer Conjugated C/EBPalpha-saRNA.
Author: Yoon, Sorah|Rossi, John J
PMID: 28639199
Journal: Int J Clin Oncol. 2017 Aug;22(4):651-659.
Title: Targeting metabolic reprogramming in KRAS-driven cancers.
Author: Kawada, Kenji|Toda, Kosuke|Sakai, Yoshiharu
PMID: 28647837
Journal: Small GTPases. 2017 Jun 28:1-8.
Title: Co-dependency between KRAS addiction and ARHGEF2 promotes an adaptive escape from MAPK pathway inhibition.
Author: Kent, Oliver A|Sandi, Maria-Jose|Rottapel, Robert
PMID: 28656876
Journal: Transgenic Res. 2017 Oct;26(5):603-612.
Title: Pancreas specific expression of oncogenes in a porcine model.
Author: Berthelsen, Martin F|Callesen, Morten M|Ostergaard, Tanja S|Liu, Ying|Li, Rong|Callesen, Henrik|Dagnaes-Hansen, Frederik|Hamilton-Dutoit, Stephen|Jakobsen, Jannik E|Thomsen, Martin K
PMID: 28664456
Journal: Sci Rep. 2017 Jul 3;7(1):4510.
Title: Pancreatic cancer: Circulating Tumor Cells and Primary Tumors show Heterogeneous KRAS Mutations.
Author: Kulemann, Birte|Rosch, Stephanie|Seifert, Sindy|Timme, Sylvia|Bronsert, Peter|Seifert, Gabriel|Martini, Verena|Kuvendjiska, Jasmina|Glatz, Torben|Hussung, Saskia|Fritsch, Ralph|Becker, Heiko|Pitman, Martha B|Hoeppner, Jens
PMID: 28674438
Journal: Mol Oncol. 2017 Oct;11(10):1413-1429.
Title: Bioinformatory-assisted analysis of next-generation sequencing data for precision medicine in pancreatic cancer.
Author: Malgerud, Linnea|Lindberg, Johan|Wirta, Valtteri|Gustafsson-Liljefors, Maria|Karimi, Masoud|Moro, Carlos Fernandez|Stecker, Katrin|Picker, Alexander|Huelsewig, Carolin|Stein, Martin|Bohnert, Regina|Del Chiaro, Marco|Haas, Stephan L|Heuchel, Rainer L|Perme
PMID: 28675654
Journal: Mol Oncol. 2017 Oct;11(10):1448-1458.
Title: An improved digital polymerase chain reaction protocol to capture low-copy KRAS mutations in plasma cell-free DNA by resolving 'subsampling' issues.
Author: Ono, Yusuke|Sugitani, Ayumu|Karasaki, Hidenori|Ogata, Munehiko|Nozaki, Reo|Sasajima, Junpei|Yokochi, Tomoki|Asahara, Shingo|Koizumi, Kazuya|Ando, Kiyohiro|Hironaka, Katsunori|Daito, Tsutomu|Mizukami, Yusuke
PMID: 28691390
Journal: Oncogenesis. 2017 Jul 10;6(7):e359.
Title: Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells.
Author: Huang, H-L|Wu, H-Y|Chu, P-C|Lai, I-L|Huang, P-H|Kulp, S K|Pan, S-L|Teng, C-M|Chen, C-S
PMID: 28692035
Journal: Genes Dev. 2017 Jun 1;31(11):1095-1108.
Title: Neat1 is a p53-inducible lincRNA essential for transformation suppression.
Author: Mello, Stephano S|Sinow, Carolyn|Raj, Nitin|Mazur, Pawel K|Bieging-Rolett, Kathryn|Broz, Daniela Kenzelmann|Imam, Jamie F Conklin|Vogel, Hannes|Wood, Laura D|Sage, Julien|Hirose, Tetsuro|Nakagawa, Shinichi|Rinn, John|Attardi, Laura D
PMID: 28698299
Journal: Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5):G524-G536.
Title: Roles of autophagy and metabolism in pancreatic cancer cell adaptation to environmental challenges.
Author: Maertin, Sandrina|Elperin, Jason M|Lotshaw, Ethan|Sendler, Matthias|Speakman, Steven D|Takakura, Kazuki|Reicher, Benjamin M|Mareninova, Olga A|Grippo, Paul J|Mayerle, Julia|Lerch, Markus M|Gukovskaya, Anna S
PMID: 28705806
Journal: J Cachexia Sarcopenia Muscle. 2017 Oct;8(5):824-838.
Title: Establishment and characterization of a novel murine model of pancreatic cancer cachexia.
Author: Michaelis, Katherine A|Zhu, Xinxia|Burfeind, Kevin G|Krasnow, Stephanie M|Levasseur, Peter R|Morgan, Terry K|Marks, Daniel L
PMID: 28730707
Journal: BMC Cancer. 2017 Jul 21;17(1):495.
Title: Expression of the scaffold connector enhancer of kinase suppressor of Ras 1 (CNKSR1) is correlated with clinical outcome in pancreatic cancer.
Author: Quadri, Humair S|Aiken, Taylor J|Allgaeuer, Michael|Moravec, Radim|Altekruse, Sean|Hussain, S Perwez|Miettinen, Markku M|Hewitt, Stephen M|Rudloff, Udo
PMID: 28732488
Journal: Mol Cancer. 2017 Jul 24;16(1):131.
Title: Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer.
Author: Chen, Ke|Qian, Weikun|Jiang, Zhengdong|Cheng, Liang|Li, Jie|Sun, Liankang|Zhou, Cancan|Gao, Luping|Lei, Meng|Yan, Bin|Cao, Junyu|Duan, Wanxing|Ma, Qingyong
PMID: 28738823
Journal: Nat Rev Clin Oncol. 2017 Sep;14(9):524-525.
Title: Pancreatic Cancer: EGFR inhibition is effective against KRAS-wild-type disease.
Author: Sidaway, Peter
PMID: 28741619
Journal: PLoS One. 2017 Jul 25;12(7):e0181532.
Title: Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas.
Author: Lu, Liming|Zeng, Jingchun
PMID: 28742845
Journal: Cell Rep. 2017 Jul 25;20(4):999-1015.
Title: A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution.
Author: Anderson, Grace R|Winter, Peter S|Lin, Kevin H|Nussbaum, Daniel P|Cakir, Merve|Stein, Elizabeth M|Soderquist, Ryan S|Crawford, Lorin|Leeds, Jim C|Newcomb, Rachel|Stepp, Priya|Yip, Catherine|Wardell, Suzanne E|Tingley, Jennifer P|Ali, Moiez|Xu, Mengmeng|Ry
PMID: 28746882
Journal: Cell Mol Gastroenterol Hepatol. 2017 May 31;4(2):263-282.
Title: Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRAS(G12D)-driven Pancreatic Tumorigenesis.
Author: Chuvin, Nicolas|Vincent, David F|Pommier, Roxane M|Alcaraz, Lindsay B|Gout, Johann|Caligaris, Cassandre|Yacoub, Karam|Cardot, Victoire|Roger, Elodie|Kaniewski, Bastien|Martel, Sylvie|Cintas, Celia|Goddard-Leon, Sophie|Colombe, Amelie|Valantin, Julie|Gadot
PMID: 28752115
Journal: Oncol Rep. 2017 Oct;38(4):2069-2077.
Title: FBW7 increases the chemosensitivity of pancreatic cancer cells to gemcitabine through upregulation of ENT1.
Author: Hu, Qiangsheng|Qin, Yi|Zhang, Bo|Liang, Chen|Ji, Shunrong|Shi, Si|Xu, Wenyan|Xiang, Jinfeng|Liang, Dingkong|Ni, Quanxing|Yu, Xianjun|Xu, Jin
PMID: 28765935
Journal: PLoS One. 2017 Aug 10;12(8):e0182562.
Title: The prognostic value of KRAS mutation by cell-free DNA in cancer patients: A systematic review and meta-analysis.
Author: Zhuang, Rongyuan|Li, Song|Li, Qian|Guo, Xi|Shen, Feng|Sun, Hong|Liu, Tianshu
PMID: 28796802
Journal: Sci Rep. 2017 Aug 11;7(1):7931.
Title: Early changes in plasma DNA levels of mutant KRAS as a sensitive marker of response to chemotherapy in pancreatic cancer.
Author: Del Re, Marzia|Vivaldi, Caterina|Rofi, Eleonora|Vasile, Enrico|Miccoli, Mario|Caparello, Chiara|d'Arienzo, Paolo Davide|Fornaro, Lorenzo|Falcone, Alfredo|Danesi, Romano
PMID: 28801547
Journal: Cancer Sci. 2017 Nov;108(11):2156-2165.
Title: c-Jun N-terminal kinase in pancreatic tumor stroma augments tumor development in mice.
Author: Sato, Takeshi|Shibata, Wataru|Hikiba, Yohko|Kaneta, Yoshihiro|Suzuki, Nobumi|Ihara, Sozaburo|Ishii, Yasuaki|Sue, Soichiro|Kameta, Eri|Sugimori, Makoto|Yamada, Hiroaki|Kaneko, Hiroaki|Sasaki, Tomohiko|Ishii, Tomohiro|Tamura, Toshihide|Kondo, Masaaki|Maeda,
PMID: 28837246
Journal: Chirurg. 2017 Nov;88(11):913-917.
Title: [Resection of main duct and mixed type IPMN >/=5 mm].
Author: Ceyhan, G O|Scheufele, F|Friess, H
PMID: 28842734
Journal: Int J Oncol. 2017 Oct;51(4):1035-1044.
Title: Phospho-valproic acid inhibits pancreatic cancer growth in mice: enhanced efficacy by its formulation in poly-(L)-lactic acid-poly(ethylene glycol) nanoparticles.
Author: Mattheolabakis, George|Wang, Ruixue|Rigas, Basil|Mackenzie, Gerardo G
PMID: 28849098
Journal: Biochem Biophys Res Commun. 2017 Nov 4;493(1):592-597.
Title: RAGE maintains high levels of NFkappaB and oncogenic Kras activity in pancreatic cancer.
Author: Azizan, Nancy|Suter, Melissa A|Liu, Yan|Logsdon, Craig D
PMID: 28867179
Journal: Biochem Biophys Res Commun. 2017 Nov 4;493(1):528-533.
Title: Modulation of RAB5A early endosome trafficking in response to KRas mediated macropinocytic fluxes in pancreatic cancer cells.
Author: Teske, Christian|Schweitzer, Christine|Palamidessi, Andrea|Aust, Daniela E|Scita, Giorgio|Weitz, Jurgen|Welsch, Thilo
PMID: 28867190
Journal: J Vis Exp. 2017 Aug 19;(126).
Title: Dissection of the Mouse Pancreas for Histological Analysis and Metabolic Profiling.
Author: Veite-Schmahl, Michelle J|Regan, Daniel P|Rivers, Adam C|Nowatzke, Joseph F|Kennedy, Michael A
PMID: 28872120
Journal: Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10202-10207.
Title: Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers.
Author: Cohen, Joshua D|Javed, Ammar A|Thoburn, Christopher|Wong, Fay|Tie, Jeanne|Gibbs, Peter|Schmidt, C Max|Yip-Schneider, Michele T|Allen, Peter J|Schattner, Mark|Brand, Randall E|Singhi, Aatur D|Petersen, Gloria M|Hong, Seung-Mo|Kim, Song Cheol|Falconi, Massi
PMID: 28874546
Journal: Nat Rev Gastroenterol Hepatol. 2017 Nov;14(11):636-638.
Title: Pancreatic cancer: Exosomes for targeting KRAS in the treatment of pancreatic cancer.
Author: Buscail, Louis
PMID: 28874835
Journal: PLoS One. 2017 Sep 8;12(9):e0184455.
Title: Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice.
Author: Chang, Hui-Hua|Moro, Aune|Takakura, Kazuki|Su, Hsin-Yuan|Mo, Allen|Nakanishi, Masako|Waldron, Richard T|French, Samuel W|Dawson, David W|Hines, O Joe|Li, Gang|Go, Vay Liang W|Sinnett-Smith, James|Pandol, Stephen J|Lugea, Aurelia|Gukovskaya, Anna S|Duff, M
PMID: 28886117
Journal: Cancer Discov. 2017 Dec;7(12):1464-1479.
Title: Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers.
Author: Seguin, Laetitia|Camargo, Maria F|Wettersten, Hiromi I|Kato, Shumei|Desgrosellier, Jay S|von Schalscha, Tami|Elliott, Kathryn C|Cosset, Erika|Lesperance, Jacqueline|Weis, Sara M|Cheresh, David A
PMID: 28893801
Journal: Sci Rep. 2017 Sep 11;7(1):11144.
Title: ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer.
Author: Drosos, Yiannis|Escobar, David|Chiang, Ming-Yi|Roys, Kathryn|Valentine, Virginia|Valentine, Marc B|Rehg, Jerold E|Sahai, Vaibhav|Begley, Lesa A|Ye, Jianming|Paul, Leena|McKinnon, Peter J|Sosa-Pineda, Beatriz
PMID: 28894253
Journal: Oncotarget. 2016 Jun 1;8(34):56081-56094.
Title: Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer.
Author: Anderson, Marybeth|Marayati, Raoud|Moffitt, Richard|Yeh, Jen Jen
PMID: 28915575
Journal: PLoS One. 2017 Sep 21;12(9):e0184984.
Title: Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele.
Author: Wu, Jinghai|Liu, Xin|Nayak, Sunayana G|Pitarresi, Jason R|Cuitino, Maria C|Yu, Lianbo|Hildreth, Blake E 3rd|Thies, Katie A|Schilling, Daniel J|Fernandez, Soledad A|Leone, Gustavo|Ostrowski, Michael C
PMID: 28934293
Journal: Biochem Biophys Res Commun. 2017 Nov 18;493(2):1018-1025.
Title: ARID1A suppresses malignant transformation of human pancreatic cells via mediating senescence-associated miR-503/CDKN2A regulatory axis.
Author: Li, Zhao-Yun|Zhu, Shan-Shan|Chen, Xian-Jun|Zhu, Jie|Chen, Qi|Zhang, Ya-Qiong|Zhang, Chun-Ling|Guo, Ting-Ting|Zhang, Li-Ming
PMID: 28942143
Journal: Cancer Res. 2017 Nov 15;77(22):6330-6339.
Title: Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers.
Author: Yau, Edwin H|Kummetha, Indrasena Reddy|Lichinchi, Gianluigi|Tang, Rachel|Zhang, Yunlin|Rana, Tariq M
PMID: 28954733
Journal: PLoS One. 2017 Sep 28;12(9):e0185687.
Title: Molecular subtype specific efficacy of MEK inhibitors in pancreatic cancers.
Author: Brauswetter, Diana|Gurbi, Bianka|Varga, Attila|Varkondi, Edit|Schwab, Richard|Banhegyi, Gabor|Fabian, Orsolya|Keri, Gyorgy|Valyi-Nagy, Istvan|Petak, Istvan
PMID: 28957417
Journal: Ann Oncol. 2017 Oct 1;28(10):2429-2435.
Title: Gemcitabine combined with the monoclonal antibody nimotuzumab is an active first-line regimen in KRAS wildtype patients with locally advanced or metastatic pancreatic cancer: a multicenter, randomized phase IIb study.
Author: Schultheis, B|Reuter, D|Ebert, M P|Siveke, J|Kerkhoff, A|Berdel, W E|Hofheinz, R|Behringer, D M|Schmidt, W E|Goker, E|De Dosso, S|Kneba, M|Yalcin, S|Overkamp, F|Schlegel, F|Dommach, M|Rohrberg, R|Steinmetz, T|Bulitta, M|Strumberg, D
PMID: 28961832
Journal: Elife. 2017 Oct 5;6. pii: 27388.
Title: Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice.
Author: Zhang, Yaqing|Yan, Wei|Mathew, Esha|Kane, Kevin T|Brannon, Arthur 3rd|Adoumie, Maeva|Vinta, Alekya|Crawford, Howard C|Pasca di Magliano, Marina
PMID: 28980940
Journal: Genome Res. 2017 Nov;27(11):1830-1842.
Title: Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways.
Author: Bhattacharyya, Sanchari|Pradhan, Kith|Campbell, Nathaniel|Mazdo, Jozef|Vasantkumar, Aparna|Maqbool, Shahina|Bhagat, Tushar D|Gupta, Sonal|Suzuki, Masako|Yu, Yiting|Greally, John M|Steidl, Ulrich|Bradner, James|Dawlaty, Meelad|Godley, Lucy|Maitra, Anirban|
PMID: 28986391
Journal: Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):113-119.
Title: Integrated expression profiling of potassium channels identifys KCNN4 as a prognostic biomarker of pancreatic cancer.
Author: Jiang, Shuheng|Zhu, Lili|Yang, Jianyu|Hu, Lipeng|Gu, Jianren|Xing, Xin|Sun, Yongwei|Zhang, Zhigang
PMID: 29050937
Journal: Nat Commun. 2017 Oct 23;8(1):1090.
Title: Survival of pancreatic cancer cells lacking KRAS function.
Author: Muzumdar, Mandar Deepak|Chen, Pan-Yu|Dorans, Kimberly Judith|Chung, Katherine Minjee|Bhutkar, Arjun|Hong, Erin|Noll, Elisa M|Sprick, Martin R|Trumpp, Andreas|Jacks, Tyler
PMID: 29061961
Journal: Semin Cancer Biol. 2017 Oct 24. pii: S1044-579X(17)30223-7.
Title: KRAS, YAP, and obesity in pancreatic cancer: A signaling network with multiple loops.
Author: Eibl, Guido|Rozengurt, Enrique
PMID: 29079305
Journal: Sci Rep. 2017 Oct 27;7(1):14631.
Title: Author Correction: Pancreatic cancer: Circulating Tumor Cells and Primary Tumors show Heterogeneous KRAS Mutations.
Author: Kulemann, Birte|Rosch, Stephanie|Seifert, Sindy|Timme, Sylvia|Bronsert, Peter|Seifert, Gabriel|Martini, Verena|Kuvendjiska, Jasmina|Glatz, Torben|Hussung, Saskia|Fritsch, Ralph|Becker, Heiko|Pitman, Martha B|Hoeppner, Jens
PMID: 29079791
Journal: Oncol Lett. 2017 Oct;14(4):4428-4432.
Title: Genetic basis of a common tumor origin in the development of pancreatic mixed acinar-neuroendocrine-ductal carcinoma: A case report.
Author: Takano, Atsushi|Hirotsu, Yosuke|Amemiya, Kenji|Nakagomi, Hiroshi|Oishi, Naoki|Oyama, Toshio|Mochizuki, Hitoshi|Omata, Masao
PMID: 29085438
Journal: World J Gastrointest Oncol. 2017 Oct 15;9(10):407-415.
Title: Ampullary cancer of intestinal origin and duodenal cancer - A logical clinical and therapeutic subgroup in periampullary cancer.
Author: Chandrasegaram, Manju D|Gill, Anthony J|Samra, Jas|Price, Tim|Chen, John|Fawcett, Jonathan|Merrett, Neil D
PMID: 29085567
Journal: Oncotarget. 2017 Sep 11;8(45):78556-78572.
Title: STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines.
Author: Grant, Trevor J|Mehta, Anita K|Gupta, Anamika|Sharif, Ahmad A D|Arora, Kshitij S|Deshpande, Vikram|Ting, David T|Bardeesy, Nabeel|Ganem, Neil J|Hergovich, Alexander|Singh, Anurag
PMID: 29108249
Journal: Oncol Lett. 2017 Nov;14(5):5980-5988.
Title: Dysregulation of KRAS signaling in pancreatic cancer is not associated with KRAS mutations and outcome.
Author: Lemstrova, Radmila|Brynychova, Veronika|Hughes, David J|Hlavac, Viktor|Dvorak, Pavel|Doherty, Joanne E|Murray, Helena A|Crockard, Martin|Oliverius, Martin|Hlavsa, Jan|Honsova, Eva|Mazanec, Jan|Kala, Zdenek|Lovecek, Martin|Havlik, Roman|Ehrmann, Jiri|Strou
PMID: 29113235
Journal: Oncotarget. 2016 Nov 8;8(48):83446-83456.
Title: A pilot study evaluating concordance between blood-based and patient-matched tumor molecular testing within pancreatic cancer patients participating in the Know Your Tumor (KYT) initiative.
Author: Pishvaian, Michael J|Joseph Bender, R|Matrisian, Lynn M|Rahib, Lola|Hendifar, Andrew|Hoos, William A|Mikhail, Sam|Chung, Vincent|Picozzi, Vincent|Heartwell, Craig|Mason, Kimberly|Varieur, Katelyn|Aberra, Metasebia|Madhavan, Subha|Petricoin, Emanuel 3rd|Br
PMID: 29137355
Journal: Oncotarget. 2017 Aug 14;8(50):87221-87233.
Title: Profiling tumour heterogeneity through circulating tumour DNA in patients with pancreatic cancer.
Author: Adamo, Patricia|Cowley, Caroline M|Neal, Christopher P|Mistry, Vilas|Page, Karen|Dennison, Ashley R|Isherwood, John|Hastings, Robert|Luo, JinLi|Moore, David A|Howard, Pringle J|Miguel, Martins L|Pritchard, Catrin|Manson, Margaret|Shaw, Jacqui A
PMID: 29152076
Journal: Biomedicines. 2017 Nov 18;5(4). pii: biomedicines5040065.
Title: Pancreatic Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells.
Author: Pelosi, Elvira|Castelli, Germana|Testa, Ugo
PMID: 29156578
Journal: Oncotarget. 2017 Sep 16;8(49):86143-86156.
Title: Isolation of circulating tumor cells from pancreatic cancer by automated filtration.
Author: Brychta, Nora|Drosch, Michael|Driemel, Christiane|Fischer, Johannes C|Neves, Rui P|Esposito, Irene|Knoefel, Wolfram|Mohlendick, Birte|Hille, Claudia|Stresemann, Antje|Krahn, Thomas|Kassack, Matthias U|Stoecklein, Nikolas H|von Ahsen, Oliver
PMID: 29156783
Journal: Mol Cell Biol. 2017 Nov 20. pii: MCB.00373-17.
Title: Sphingomyelin metabolism is a regulator of KRAS function.
Author: van der Hoeven, Dharini|Cho, Kwang-Jin|Zhou, Yong|Ma, Xiaoping|Chen, Wei|Naji, Ali|Montufar-Solis, Dina|Zuo, Yan|Kovar, Sarah E|Levental, Kandice R|Frost, Jeffrey A|van der Hoeven, Ransome|Hancock, John F
PMID: 29158292
Journal: Semin Cancer Biol. 2017 Nov 21. pii: S1044-579X(17)30235-3.
Title: Challenges in Ras therapeutics in pancreatic cancer.
Author: Choi, Minsig|Bien, Harold|Mofunanya, Adaobi|Powers, Scott
PMID: 29170065
Journal: Oncotarget. 2017 Oct 4;8(54):92667-92681.
Title: Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer.
Author: Schultz, Michelle A|Diaz, Andrew M|Smite, Sharon|Lay, Anna R|DeCant, Brian|McKinney, Ronald|Mascarinas, Windel E|Xia, Yinglin|Neumann, Carola|Bentrem, David|Dawson, David W|Grippo, Paul J
PMID: 29190947
Journal: Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10947-E10955.
Title: Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous.
Author: Chung, Wei-Jen|Daemen, Anneleen|Cheng, Jason H|Long, Jason E|Cooper, Jonathan E|Wang, Bu-Er|Tran, Christopher|Singh, Mallika|Gnad, Florian|Modrusan, Zora|Foreman, Oded|Junttila, Melissa R
PMID: 29203670
Journal: Oncotarget. 2017 Jun 28;8(55):93464-93475.
Title: Assessment of pancreatic neuroendocrine tumor cytologic genotype diversity to guide personalized medicine using a custom gastroenteropancreatic next-generation sequencing panel.
Author: Gleeson, Ferga C|Voss, Jesse S|Kipp, Benjamin R|Kerr, Sarah E|Van Arnam, John S|Mills, John R|Marcou, Cherisse A|Schneider, Amber R|Tu, Zheng Jin|Henry, Michael R|Levy, Michael J
PMID: 29212165
Journal: Oncotarget. 2017 Oct 26;8(58):97822-97834.
Title: Lack of chemopreventive effects of P2X7R inhibitors against pancreatic cancer.
Author: Mohammed, Altaf|Janakiram, Naveena B|Madka, Venkateshwar|Pathuri, Gopal|Li, Qian|Ritchie, Rebekah|Biddick, Laura|Kutche, Hannah|Zhang, Yuting|Singh, Anil|Gali, Hariprasad|Lightfoot, Stan|Steele, Vernon E|Suen, Chen S|Rao, Chinthalapally V
PMID: 29228654
Journal: Oncotarget. 2017 Sep 1;8(59):99552-99566.
Title: EVI1 modulates oncogenic role of GPC1 in pancreatic carcinogenesis.
Author: Tanaka, Mariko|Ishikawa, Shumpei|Ushiku, Tetsuo|Morikawa, Teppei|Isagawa, Takayuki|Yamagishi, Makoto|Yamamoto, Hiroyuki|Katoh, Hiroto|Takeshita, Kimiko|Arita, Junichi|Sakamoto, Yoshihiro|Hasegawa, Kiyoshi|Kokudo, Norihiro|Fukayama, Masashi
PMID: 29245923
Journal: Front Immunol. 2017 Dec 4;8:1606.
Title: Suppression of Gingival NK Cells in Precancerous and Cancerous Stages of Pancreatic Cancer in KC and BLT-Humanized Mice.
Author: Kaur, Kawaljit|Chang, Hui-Hua|Cook, Jessica|Eibl, Guido|Jewett, Anahid
PMID: 29255459
Journal: BMJ Open. 2017 Dec 26;7(12):e018175.
Title: Comparing the diagnostic accuracy of five common tumour biomarkers and CA19-9 for pancreatic cancer: a protocol for a network meta-analysis of diagnostic test accuracy.
Author: Ge, Long|Pan, Bei|Song, Fujian|Ma, Jichun|Zeraatkar, Dena|Zhou, Jianguo|Tian, Jinhui
PMID: 29282264
Journal: Medicine (Baltimore). 2017 Dec;96(50):e9217.
Title: Utility of KRAS mutational analysis in the preoperative diagnosis of synchronous pancreatic cancer and intrahepatic cholangiocarcinoma: A case report.
Author: Eso, Yuji|Uza, Norimitsu|Yamagishi, Hiroko|Imada, Kazuaki|Kimura, Yuto|Masui, Toshihiko|Kodama, Yuzo|Seno, Hiroshi
PMID: 29390348
Journal: Gut. 2018 Jan;67(1):146-156.
Title: Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy.
Author: Kong, Bo|Bruns, Philipp|Behler, Nora A|Chang, Ligong|Schlitter, Anna Melissa|Cao, Jing|Gewies, Andreas|Ruland, Jurgen|Fritzsche, Sina|Valkovskaya, Nataliya|Jian, Ziying|Regel, Ivonne|Raulefs, Susanne|Irmler, Martin|Beckers, Johannes|Friess, Helmut|Erkan,
PMID: 27646934
Journal: Gut. 2018 Feb;67(2):320-332.
Title: IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer.
Author: Mace, Thomas A|Shakya, Reena|Pitarresi, Jason R|Swanson, Benjamin|McQuinn, Christopher W|Loftus, Shannon|Nordquist, Emily|Cruz-Monserrate, Zobeida|Yu, Lianbo|Young, Gregory|Zhong, Xiaoling|Zimmers, Teresa A|Ostrowski, Michael C|Ludwig, Thomas|Bloomston, M
PMID: 27797936
Journal: Small GTPases. 2018 Nov 2;9(6):452-456.
Title: Targeting integrin-linked kinase to suppress oncogenic KRAS signaling in pancreatic cancer.
Author: Chu, Po-Chen|Kulp, Samuel K|Bekaii-Saab, Tanios|Chen, Ching-Shih
PMID: 27936345
Journal: Gut. 2018 Mar;67(3):497-507.
Title: Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer.
Author: Hessmann, E|Patzak, M S|Klein, L|Chen, N|Kari, V|Ramu, I|Bapiro, T E|Frese, K K|Gopinathan, A|Richards, F M|Jodrell, D I|Verbeke, C|Li, X|Heuchel, R|Lohr, J M|Johnsen, S A|Gress, T M|Ellenrieder, V|Neesse, A
PMID: 28077438
Journal: Gut. 2018 Apr;67(4):707-718.
Title: c-Myc downregulation is required for preacinar to acinar maturation and pancreatic homeostasis.
Author: Sanchez-Arevalo Lobo, Victor J|Fernandez, Luis Cesar|Carrillo-de-Santa-Pau, Enrique|Richart, Laia|Cobo, Isidoro|Cendrowski, Jaroslaw|Moreno, Ulisses|Del Pozo, Natalia|Megias, Diego|Breant, Bernardette|Wright, Christopher V|Magnuson, Mark|Real, Francisco X
PMID: 28159836
Journal: Int J Hyperthermia. 2018 May;34(3):284-291.
Title: Hyperthermia-enhanced targeted drug delivery using magnetic resonance-guided focussed ultrasound: a pre-clinical study in a genetic model of pancreatic cancer.
Author: Farr, Navid|Wang, Yak-Nam|D'Andrea, Samantha|Starr, Frank|Partanen, Ari|Gravelle, Kayla M|McCune, Jeannine S|Risler, Linda J|Whang, Stella G|Chang, Amy|Hingorani, Sunil R|Lee, Donghoon|Hwang, Joo Ha
PMID: 28715967
Journal: Oncogene. 2018 Jan 4;37(1):128-138.
Title: CDKN2B deletion is essential for pancreatic cancer development instead of unmeaningful co-deletion due to juxtaposition to CDKN2A.
Author: Tu, Q|Hao, J|Zhou, X|Yan, L|Dai, H|Sun, B|Yang, D|An, S|Lv, L|Jiao, B|Chen, C|Lai, R|Shi, P|Zhao, X
PMID: 28892048
Journal: Oncogene. 2018 Feb 8;37(6):821-832.
Title: RAF inhibitor LY3009120 sensitizes RAS or BRAF mutant cancer to CDK4/6 inhibition by abemaciclib via superior inhibition of phospho-RB and suppression of cyclin D1.
Author: Chen, S-H|Gong, X|Zhang, Y|Van Horn, R D|Yin, T|Huber, L|Burke, T F|Manro, J|Iversen, P W|Wu, W|Bhagwat, S V|Beckmann, R P|Tiu, R V|Buchanan, S G|Peng, S-B
PMID: 29059158
Journal: Oncogene. 2018 Feb 15;37(7):912-923.
Title: SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer.
Author: Zhou, H|Qin, Y|Ji, S|Ling, J|Fu, J|Zhuang, Z|Fan, X|Song, L|Yu, X|Chiao, P J
PMID: 29059173
Journal: Cancer Biomark. 2018 Feb 6;21(2):323-334.
Title: Long-term survivors of pancreatic adenocarcinoma show low rates of genetic alterations in KRAS, TP53 and SMAD4.
Author: Masetti, Michele|Acquaviva, Giorgia|Visani, Michela|Tallini, Giovanni|Fornelli, Adele|Ragazzi, Moira|Vasuri, Francesco|Grifoni, Daniela|Di Giacomo, Simone|Fiorino, Sirio|Lombardi, Raffaele|Tuminati, David|Ravaioli, Matteo|Fabbri, Carlo|Bacchi-Reggiani, Ma
PMID: 29103024
Journal: Biomaterials. 2018 Jan;152:37-46.
Title: Ultrasensitive MRI detection of spontaneous pancreatic tumors with nanocage-based targeted contrast agent.
Author: Kawano, Takahito|Murata, Masaharu|Kang, Jeong-Hun|Piao, Jing Shu|Narahara, Sayoko|Hyodo, Fuminori|Hamano, Nobuhito|Guo, Jie|Oguri, Susumu|Ohuchida, Kenoki|Hashizume, Makoto
PMID: 29107217
Journal: Int J Obes (Lond). 2018 Mar;42(3):334-343.
Title: Adipocytes sustain pancreatic cancer progression through a non-canonical WNT paracrine network inducing ROR2 nuclear shuttling.
Author: Carbone, C|Piro, G|Gaianigo, N|Ligorio, F|Santoro, R|Merz, V|Simionato, F|Zecchetto, C|Falco, G|Conti, G|Kamga, P T|Krampera, M|Di Nicolantonio, F|De Franceschi, L|Scarpa, A|Tortora, G|Melisi, D
PMID: 29151594
Journal: Cancer Lett. 2018 Feb 28;415:129-150.
Title: Diabetes as risk factor for pancreatic cancer: Hyperglycemia promotes epithelial-mesenchymal-transition and stem cell properties in pancreatic ductal epithelial cells.
Author: Rahn, Sascha|Zimmermann, Vivien|Viol, Fabrice|Knaack, Hendrike|Stemmer, Kerstin|Peters, Lena|Lenk, Lennart|Ungefroren, Hendrik|Saur, Dieter|Schafer, Heiner|Helm, Ole|Sebens, Susanne
PMID: 29222037
Journal: Cold Spring Harb Perspect Med. 2018 Sep 4;8(9). pii: cshperspect.a031435.
Title: KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer.
Author: Waters, Andrew M|Der, Channing J
PMID: 29229669
Journal: J Exp Med. 2018 Jan 2;215(1):177-195.
Title: Cilia loss sensitizes cells to transformation by activating the mevalonate pathway.
Author: Deng, Yue-Zhen|Cai, Zhen|Shi, Shuo|Jiang, Hao|Shang, Yu-Rong|Ma, Ning|Wang, Jing-Jing|Guan, Dong-Xian|Chen, Tian-Wei|Rong, Ye-Fei|Qian, Zhen-Yu|Zhang, Er-Bin|Feng, Dan|Zhou, Quan-Li|Du, Yi-Nan|Liu, Dong-Ping|Huang, Xing-Xu|Liu, Lu-Ming|Chin, Eugene|Li, Da
PMID: 29237705
Journal: Gastroenterology. 2018 Apr;154(5):1480-1493.
Title: JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice.
Author: Song, Xinxin|Zhu, Shan|Xie, Yangchun|Liu, Jiao|Sun, Lingyi|Zeng, Dexing|Wang, Pengcheng|Ma, Xiaochao|Kroemer, Guido|Bartlett, David L|Billiar, Timothy R|Lotze, Michael T|Zeh, Herbert J|Kang, Rui|Tang, Daolin
PMID: 29248440
Journal: Gastroenterology. 2018 Apr;154(5):1494-1508.e13.
Title: Kruppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice.
Author: He, Ping|Yang, Jong Won|Yang, Vincent W|Bialkowska, Agnieszka B
PMID: 29248441
Journal: Cancer Cell. 2018 Jan 8;33(1):75-90.e7.
Title: beta2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer.
Author: Renz, Bernhard W|Takahashi, Ryota|Tanaka, Takayuki|Macchini, Marina|Hayakawa, Yoku|Dantes, Zahra|Maurer, H Carlo|Chen, Xiaowei|Jiang, Zhengyu|Westphalen, C Benedikt|Ilmer, Matthias|Valenti, Giovanni|Mohanta, Sarajo K|Habenicht, Andreas J R|Middelhoff, Mor
PMID: 29249692
Journal: Exp Ther Med. 2018 Jan;15(1):527-531.
Title: Detection of K-ras gene mutations in feces by magnetic nanoprobe in patients with pancreatic cancer: A preliminary study.
Author: Wang, Xiaoguang|Wang, Jingshuai|Chen, Fei|Zhong, Zhengxiang|Qi, Lifeng
PMID: 29250161
Journal: Biochem Biophys Res Commun. 2018 Jan 8;495(2):2058-2065.
Title: NK cell and IFN signatures are positive prognostic biomarkers for resectable pancreatic cancer.
Author: Hoshikawa, Mayumi|Aoki, Taku|Matsushita, Hirokazu|Karasaki, Takahiro|Hosoi, Akihiro|Odaira, Kosuke|Fujieda, Nao|Kobayashi, Yukari|Kambara, Kaori|Ohara, Osamu|Arita, Junichi|Hasegawa, Kiyoshi|Kakimi, Kazuhiro|Kokudo, Norihiro
PMID: 29253566
Journal: Cancer Res. 2018 Mar 1;78(5):1321-1333.
Title: Inactivation of Cancer-Associated-Fibroblasts Disrupts Oncogenic Signaling in Pancreatic Cancer Cells and Promotes Its Regression.
Author: Dauer, Patricia|Zhao, Xianda|Gupta, Vineet K|Sharma, Nikita|Kesh, Kousik|Gnamlin, Prisca|Dudeja, Vikas|Vickers, Selwyn M|Banerjee, Sulagna|Saluja, Ashok
PMID: 29259015
Journal: Cancer Res. 2018 Feb 15;78(4):985-1002.
Title: Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells.
Author: Chen, Pan-Yu|Muzumdar, Mandar Deepak|Dorans, Kimberly Judith|Robbins, Rebecca|Bhutkar, Arjun|Del Rosario, Amanda|Mertins, Philipp|Qiao, Jana|Schafer, Anette Claudia|Gertler, Frank|Carr, Steven|Jacks, Tyler
PMID: 29279356
Journal: Pancreatology. 2018 Mar;18(2):184-190.
Title: Investigating the role of transcription factors of pancreas development in pancreatic cancer.
Author: Naqvi, Ahmad Abu Turab|Hasan, Gulam Mustafa|Hassan, Md Imtaiyaz
PMID: 29289465
Journal: J Cancer. 2018 Jan 1;9(1):21-31.
Title: Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profile in Pancreatic Cancer Derived Exosomes Treated Dendritic Cells by Microarray Analysis.
Author: Chen, Jionghuang|Wang, Shaowen|Jia, Shengnan|Ding, Guoping|Jiang, Guixing|Cao, Liping
PMID: 29290766
Journal: Clin Chem. 2018 Mar;64(3):536-546.
Title: In Situ Detection and Quantification of AR-V7, AR-FL, PSA, and KRAS Point Mutations in Circulating Tumor Cells.
Author: El-Heliebi, Amin|Hille, Claudia|Laxman, Navya|Svedlund, Jessica|Haudum, Christoph|Ercan, Erkan|Kroneis, Thomas|Chen, Shukun|Smolle, Maria|Rossmann, Christopher|Krzywkowski, Tomasz|Ahlford, Annika|Darai, Evangelia|von Amsberg, Gunhild|Alsdorf, Winfried|Kon
PMID: 29301749
Journal: Cancer Biol Ther. 2018 Apr 3;19(4):316-327.
Title: Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma.
Author: Kanteti, Rajani|Mirzapoiazova, Tamara|Riehm, Jacob J|Dhanasingh, Immanuel|Mambetsariev, Bolot|Wang, Jiale|Kulkarni, Prakash|Kaushik, Garima|Seshacharyulu, Parthasarathy|Ponnusamy, Moorthy P|Kindler, Hedy L|Nasser, Mohd W|Batra, Surinder K|Salgia, Ravi
PMID: 29303405
Journal: Pancreas. 2018 Feb;47(2):227-232.
Title: Progression of Chronic Pancreatitis to Pancreatic Cancer: Is There a Role of Gene Mutations as a Screening Tool?
Author: Rashid, Sumaira|Singh, Nidhi|Gupta, Surabhi|Rashid, Safoora|Nalika, Nandini|Sachdev, Vikas|Bal, Chandra Sekhar|Datta Gupta, Siddhartha|Chauhan, Shyam S|Saraya, Anoop
PMID: 29303908
Journal: Int J Cancer. 2018 Jun 1;142(11):2323-2334.
Title: KRAS promotes tumor metastasis and chemoresistance by repressing RKIP via the MAPK-ERK pathway in pancreatic cancer.
Author: Yang, Kege|Li, Yaqing|Lian, Guoda|Lin, Haoming|Shang, Changzhen|Zeng, Linjuan|Chen, Shaojie|Li, Jiajia|Huang, Chumei|Huang, Kaihong|Chen, Yinting
PMID: 29315556
Journal: Cancers (Basel). 2018 Jan 10;10(1). pii: cancers10010014.
Title: Targeting Pancreatic Cancer Cell Plasticity: The Latest in Therapeutics.
Author: Smigiel, Jacob M|Parameswaran, Neetha|Jackson, Mark W
PMID: 29320425
Journal: Cell Stem Cell. 2018 Mar 1;22(3):454-467.e6.
Title: Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression.
Author: Seino, Takashi|Kawasaki, Shintaro|Shimokawa, Mariko|Tamagawa, Hiroki|Toshimitsu, Kohta|Fujii, Masayuki|Ohta, Yuki|Matano, Mami|Nanki, Kosaku|Kawasaki, Kenta|Takahashi, Sirirat|Sugimoto, Shinya|Iwasaki, Eisuke|Takagi, Junichi|Itoi, Takao|Kitago, Minoru|Kit
PMID: 29337182
Journal: Mol Ther Methods Clin Dev. 2017 Sep 30;8:8-20.
Title: Safety and Efficacy of AAV Retrograde Pancreatic Ductal Gene Delivery in Normal and Pancreatic Cancer Mice.
Author: Quirin, Kayla A|Kwon, Jason J|Alioufi, Arafat|Factora, Tricia|Temm, Constance J|Jacobsen, Max|Sandusky, George E|Shontz, Kim|Chicoine, Louis G|Clark, K Reed|Mendell, Joshua T|Korc, Murray|Kota, Janaiah
PMID: 29349096
Journal: Br J Cancer. 2018 Mar 6;118(5):662-669.
Title: KRAS mutations in cell-free DNA from preoperative and postoperative sera as a pancreatic cancer marker: a retrospective study.
Author: Nakano, Yutaka|Kitago, Minoru|Matsuda, Sachiko|Nakamura, Yuki|Fujita, Yusuke|Imai, Shunichi|Shinoda, Masahiro|Yagi, Hiroshi|Abe, Yuta|Hibi, Taizo|Fujii-Nishimura, Yoko|Takeuchi, Ayano|Endo, Yutaka|Itano, Osamu|Kitagawa, Yuko
PMID: 29360815
Journal: Nature. 2018 Feb 1;554(7690):62-68.
Title: Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes.
Author: Mueller, Sebastian|Engleitner, Thomas|Maresch, Roman|Zukowska, Magdalena|Lange, Sebastian|Kaltenbacher, Thorsten|Konukiewitz, Bjorn|Ollinger, Rupert|Zwiebel, Maximilian|Strong, Alex|Yen, Hsi-Yu|Banerjee, Ruby|Louzada, Sandra|Fu, Beiyuan|Seidler, Barbara|G
PMID: 29364867
Journal: JCI Insight. 2018 Jan 25;3(2). pii: 97422.
Title: Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma.
Author: Schofield, Heather K|Zeller, Jorg|Espinoza, Carlos|Halbrook, Christopher J|Del Vecchio, Annachiara|Magnuson, Brian|Fabo, Tania|Daylan, Ayse Ece Cali|Kovalenko, Ilya|Lee, Ho-Joon|Yan, Wei|Feng, Ying|Karim, Saadia A|Kremer, Daniel M|Kumar-Sinha, Chandan|Lys
PMID: 29367463
Journal: Oncogene. 2018 Apr;37(14):1845-1856.
Title: Genetic and pharmacologic abrogation of Snail1 inhibits acinar-to-ductal metaplasia in precursor lesions of pancreatic ductal adenocarcinoma and pancreatic injury.
Author: Fendrich, Volker|Jendryschek, Frederike|Beeck, Saskia|Albers, Max|Lauth, Matthias|Esni, Farzad|Heeger, Kristin|Dengler, Janina|Slater, Emily P|Holler, Julia P N|Baier, Aninja|Bartsch, Detlef K|Waldmann, Jens
PMID: 29367759
Journal: Oncologist. 2018 May;23(5):566-572.
Title: Mutant KRAS Circulating Tumor DNA Is an Accurate Tool for Pancreatic Cancer Monitoring.
Author: Perets, Ruth|Greenberg, Orli|Shentzer, Talia|Semenisty, Valeria|Epelbaum, Ron|Bick, Tova|Sarji, Shada|Ben-Izhak, Ofer|Sabo, Edmond|Hershkovitz, Dov
PMID: 29371474
Journal: PLoS One. 2018 Feb 1;13(2):e0192264.
Title: Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer.
Author: Cheng, Yating|Imanirad, Parisa|Jutooru, Indira|Hedrick, Erik|Jin, Un-Ho|Rodrigues Hoffman, Aline|Leal de Araujo, Jeann|Morpurgo, Benjamin|Golovko, Andrei|Safe, Stephen
PMID: 29389953
Journal: Nat Rev Gastroenterol Hepatol. 2018 Mar;15(3):130.
Title: Pancreatic cancer: KRAS dosage key in PDAC.
Author: Thomas, Hugh
PMID: 29410532
Journal: Cancer Discov. 2018 Mar;8(3):265.
Title: KRAS(G12D) Gene Dosage Drives Pancreatic Tumor Evolution and Progression.
Author:
PMID: 29420182
Journal: J Surg Res. 2018 Mar;223:230-236.
Title: Expression of neuropeptide Y and its receptors Y1 and Y2 in pancreatic intraepithelial neoplasia and invasive pancreatic cancer in a transgenic mouse model and human samples of pancreatic cancer.
Author: Waldmann, Jens|Fendrich, Volker|Reichert, Martin|Hecker, Andreas|Bartsch, Detlef K|Padberg, Winfried|Holler, Julia P N
PMID: 29433879
Journal: Cancer Lett. 2018 May 1;421:161-169.
Title: Combination of Kras activation and PTEN deletion contributes to murine hepatopancreatic ductal malignancy.
Author: Lin, Yun-Kai|Fang, Zheng|Jiang, Tian-Yi|Wan, Zheng-Hua|Pan, Yu-Fei|Ma, Yun-Han|Shi, Yuan-Yuan|Tan, Ye-Xiong|Dong, Li-Wei|Zhang, Yong-Jie|Wang, Hong-Yang
PMID: 29452147
Journal: Oncotarget. 2017 Dec 23;9(5):5931-5943.
Title: Pathological and functional significance of Semaphorin-5A in pancreatic cancer progression and metastasis.
Author: Saxena, Sugandha|Hayashi, Yuri|Wu, Lingyun|Awaji, Mohammad|Atri, Pranita|Varney, Michelle L|Purohit, Abhilasha|Rachagani, Satyanarayana|Batra, Surinder K|Singh, Rakesh K
PMID: 29464045
Journal: Oncotarget. 2018 Jan 8;9(6):6938-6951.
Title: Spiclomazine displays a preferential anti-tumor activity in mutant KRas-driven pancreatic cancer.
Author: Guo, Xiaoyu|Zhao, Wenjing|Liu, Zuojia|Wang, Jin
PMID: 29467941
Journal: Technol Cancer Res Treat. 2018 Jan 1;17:1533034618754475.
Title: Loss of ARID1A Expression Correlates With Tumor Differentiation and Tumor Progression Stage in Pancreatic Ductal Adenocarcinoma.
Author: Zhang, Li|Wang, Cuiping|Yu, Shuangni|Jia, Congwei|Yan, Jie|Lu, Zhaohui|Chen, Jie
PMID: 29486633
Journal: Cancer Res. 2018 May 15;78(10):2624-2637.
Title: Zeb1 in Stromal Myofibroblasts Promotes Kras-Driven Development of Pancreatic Cancer.
Author: Sangrador, Irene|Molero, Xavier|Campbell, Fiona|Franch-Exposito, Sebastia|Rovira-Rigau, Maria|Samper, Esther|Dominguez-Fraile, Manuel|Fillat, Cristina|Castells, Antoni|Vaquero, Eva C
PMID: 29490942
Journal: Arch Pathol Lab Med. 2018 Mar;142(3):420-423.
Title: Intraductal Tubulopapillary Neoplasm of the Pancreas: An Overview.
Author: Kim, Hyunsung|Ro, Jae Y
PMID: 29494224
Journal: J Pathol. 2018 Jun;245(2):197-208.
Title: The advanced glycation end-product N() -carboxymethyllysine promotes progression of pancreatic cancer: implications for diabetes-associated risk and its prevention.
Author: Menini, Stefano|Iacobini, Carla|de Latouliere, Luisa|Manni, Isabella|Ionta, Vittoria|Blasetti Fantauzzi, Claudia|Pesce, Carlo|Cappello, Paola|Novelli, Francesco|Piaggio, Giulia|Pugliese, Giuseppe
PMID: 29533466
Journal: J Am Chem Soc. 2018 Apr 4;140(13):4473-4476.
Title: Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids.
Author: Gebregiworgis, Teklab|Marshall, Christopher B|Nishikawa, Tadateru|Radulovich, Nikolina|Sandi, Maria-Jose|Fang, Zhenhao|Rottapel, Robert|Tsao, Ming-Sound|Ikura, Mitsuhiko
PMID: 29543440
Journal: J Gastrointest Oncol. 2018 Feb;9(1):1-10.
Title: A KRAS wild type mutational status confers a survival advantage in pancreatic ductal adenocarcinoma.
Author: Windon, Annika L|Loaiza-Bonilla, Arturo|Jensen, Christopher E|Randall, Michael|Morrissette, Jennifer J D|Shroff, Stuti G
PMID: 29564165
Journal: Arch Pathol Lab Med. 2018 Apr;142(4):458-464.
Title: The Role of Next-Generation Sequencing in the Cytologic Diagnosis of Pancreatic Lesions.
Author: de Biase, Dario|Visani, Michela|Acquaviva, Giorgia|Fornelli, Adele|Masetti, Michele|Fabbri, Carlo|Pession, Annalisa|Tallini, Giovanni
PMID: 29565213
Journal: Hum Pathol. 2018 Jul;77:70-79.
Title: Pancreatic neuroendocrine carcinomas reveal a closer relationship to ductal adenocarcinomas than to neuroendocrine tumors G3.
Author: Konukiewitz, Bjorn|Jesinghaus, Moritz|Steiger, Katja|Schlitter, Anna Melissa|Kasajima, Atsuko|Sipos, Bence|Zamboni, Giuseppe|Weichert, Wilko|Pfarr, Nicole|Kloppel, Gunter
PMID: 29596894
Journal: Gastroenterology. 2018 Jul;155(1):210-223.e3.
Title: Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells.
Author: Zhang, Yu|Zoltan, Michelle|Riquelme, Erick|Xu, Hanwen|Sahin, Ismet|Castro-Pando, Susana|Montiel, Maria Fernanda|Chang, Kyle|Jiang, Zhengyu|Ling, Jianhua|Gupta, Sonal|Horne, William|Pruski, Melissa|Wang, Huamin|Sun, Shao-Cong|Lozano, Guillermina|Chiao, Pau
PMID: 29604293
Journal: Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3769-E3778.
Title: Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor-stroma crosstalk.
Author: Orozco, Carlos A|Martinez-Bosch, Neus|Guerrero, Pedro E|Vinaixa, Judith|Dalotto-Moreno, Tomas|Iglesias, Mar|Moreno, Mireia|Djurec, Magdolna|Poirier, Francoise|Gabius, Hans-Joachim|Fernandez-Zapico, Martin E|Hwang, Rosa F|Guerra, Carmen|Rabinovich, Gabriel
PMID: 29615514
Journal: Cell Chem Biol. 2018 Jun 21;25(6):705-717.e11.
Title: Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers.
Author: Koundinya, Malvika|Sudhalter, Judith|Courjaud, Albane|Lionne, Bruno|Touyer, Gaetan|Bonnet, Luc|Menguy, Isabelle|Schreiber, Isabelle|Perrault, Christelle|Vougier, Stephanie|Benhamou, Brigitte|Zhang, Bailin|He, Timothy|Gao, Qiang|Gee, Patricia|Simard, Danie
PMID: 29628435
Journal: Mol Med Rep. 2018 Jun;17(6):8061-8068.
Title: Intraductal papillary mucinous neoplasms of the pancreas: Clinical association with KRAS.
Author: Chang, Xiao Yan|Wu, Yan|Li, Yuan|Wang, Jing|Chen, Jie
PMID: 29658583
Journal: J Surg Res. 2018 Jun;226:122-130.
Title: RT-PCR of peritoneal washings predicts peritoneal pancreatic cancer recurrence.
Author: Sato, Kei|Mori, Ryutaro|Hiroshima, Yukihiko|Oba, Mari S|Matsuyama, Ryusei|Bouvet, Michael|Hoffman, Robert M|Endo, Itaru
PMID: 29661277
Journal: JCI Insight. 2018 Apr 19;3(8). pii: 99263.
Title: Generation and testing of clinical-grade exosomes for pancreatic cancer.
Author: Mendt, Mayela|Kamerkar, Sushrut|Sugimoto, Hikaru|McAndrews, Kathleen M|Wu, Chia-Chin|Gagea, Mihai|Yang, Sujuan|Blanko, Elena V Rodriges|Peng, Qian|Ma, Xiaoyan|Marszalek, Joseph R|Maitra, Anirban|Yee, Cassian|Rezvani, Katayoun|Shpall, Elizabeth|LeBleu, Val
PMID: 29669940
Journal: Sci Rep. 2018 Apr 18;8(1):6150.
Title: Overexpression of HER2 in the pancreas promotes development of intraductal papillary mucinous neoplasms in mice.
Author: Shibata, Wataru|Kinoshita, Hiroto|Hikiba, Yohko|Sato, Takeshi|Ishii, Yasuaki|Sue, Soichiro|Sugimori, Makoto|Suzuki, Nobumi|Sakitani, Kosuke|Ijichi, Hideaki|Mori, Ryutaro|Endo, Itaru|Maeda, Shin
PMID: 29670173
Journal: SLAS Discov. 2018 Jul;23(6):574-584.
Title: Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening.
Author: Hou, Shurong|Tiriac, Herve|Sridharan, Banu Priya|Scampavia, Louis|Madoux, Franck|Seldin, Jan|Souza, Glauco R|Watson, Donald|Tuveson, David|Spicer, Timothy P
PMID: 29673279
Journal: Mol Carcinog. 2018 Sep;57(9):1130-1143.
Title: A novel tricarbonylmethane agent (CMC2.24) reduces human pancreatic tumor growth in mice by targeting Ras.
Author: Mallangada, Naveen A|Vargas, Joselin M|Thomas, Swaroopa|DiGiovanni, Matthew G|Vaeth, Brandon M|Nemesure, Matthew D|Wang, Ruixue|LaComb, Joseph F|Williams, Jennie L|Golub, Lorne M|Johnson, Francis|Mackenzie, Gerardo G
PMID: 29683208
Journal: J Vis Exp. 2018 Apr 7;(134).
Title: Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models.
Author: Goetze, Robert-Guenther|Buchholz, Soeren M|Patil, Shilpa|Petzold, Golo|Ellenrieder, Volker|Hessmann, Elisabeth|Neesse, Albrecht
PMID: 29683461
Journal: Cell Mol Gastroenterol Hepatol. 2017 Nov 10;5(2):169-185.e2.
Title: Pancreatic HIF2alpha Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm.
Author: Schofield, Heather K|Tandon, Manuj|Park, Min-Jung|Halbrook, Christopher J|Ramakrishnan, Sadeesh K|Kim, Esther C|Shi, Jiaqi|Omary, M Bishr|Shah, Yatrik M|Esni, Farzad|Pasca di Magliano, Marina
PMID: 29693047
Journal: J Clin Pathol. 2018 Oct;71(10):865-873.
Title: KRAS fluorescence in situ hybridisation testing for the detection and diagnosis of pancreatic adenocarcinoma.
Author: Shiroma, Noriyuki|Arihiro, Koji|Oda, Miyo|Orita, Makoto
PMID: 29695486
Journal: Biochim Biophys Acta Rev Cancer. 2018 Apr 24. pii: S0304-419X(17)30213-5.
Title: The plasticity of pancreatic cancer metabolism in tumor progression and therapeutic resistance.
Author: Biancur, Douglas E|Kimmelman, Alec C
PMID: 29702208
Journal: J Tradit Complement Med. 2017 May 3;8(2):282-288.
Title: Analysis of Kras gene from induced pancreatic cancer rats administered with Momordicacharantia and Ocimumbasilicum leaf extracts.
Author: Minari, J B|Okelola, C A|Ugochukwu, N C
PMID: 29736383
Journal: Mol Cancer Res. 2018 Aug;16(8):1255-1262.
Title: Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models of Pancreatic Cancer.
Author: Kishikawa, Takahiro|Otsuka, Motoyuki|Suzuki, Tatsunori|Seimiya, Takahiro|Sekiba, Kazuma|Ishibashi, Rei|Tanaka, Eri|Ohno, Motoko|Yamagami, Mari|Koike, Kazuhiko
PMID: 29748382
Journal: Chem Sci. 2018 Apr 24;9(18):4299-4307.
Title: Triple action Pt(iv) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance.
Author: Petruzzella, Emanuele|Sirota, Roman|Solazzo, Irene|Gandin, Valentina|Gibson, Dan
PMID: 29780561
Journal: Mol Oncol. 2018 Jun;12(7):1203-1215.
Title: Matrine suppresses KRAS-driven pancreatic cancer growth by inhibiting autophagy-mediated energy metabolism.
Author: Cho, Young-Ra|Lee, Ji Hyeon|Kim, Ji Hye|Lee, So-Yeon|Yoo, Suna|Jung, Min-Kyo|Kim, Su Jung|Yoo, Hyun Ju|Pack, Chang-Gi|Rho, Jin Kyung|Son, Jaekyoung
PMID: 29791786
Journal: Cancer Discov. 2018 Sep;8(9):1087-1095.
Title: NRG1 Fusions in KRAS Wild-Type Pancreatic Cancer.
Author: Heining, Christoph|Horak, Peter|Uhrig, Sebastian|Codo, Paula L|Klink, Barbara|Hutter, Barbara|Frohlich, Martina|Bonekamp, David|Richter, Daniela|Steiger, Katja|Penzel, Roland|Endris, Volker|Ehrenberg, Karl Roland|Frank, Stephanie|Kleinheinz, Kortine|Topra
PMID: 29802158
Journal: Nat Commun. 2018 May 25;9(1):2081.
Title: In vivo reprogramming drives Kras-induced cancer development.
Author: Shibata, Hirofumi|Komura, Shingo|Yamada, Yosuke|Sankoda, Nao|Tanaka, Akito|Ukai, Tomoyo|Kabata, Mio|Sakurai, Satoko|Kuze, Bunya|Woltjen, Knut|Haga, Hironori|Ito, Yatsuji|Kawaguchi, Yoshiya|Yamamoto, Takuya|Yamada, Yasuhiro
PMID: 29802314
Journal: PLoS One. 2018 May 31;13(5):e0193644.
Title: KRAS mutant allele-specific expression knockdown in pancreatic cancer model with systemically delivered bi-shRNA KRAS lipoplex.
Author: Rao, Donald D|Luo, Xiuquan|Wang, Zhaohui|Jay, Christopher M|Brunicardi, Francis C|Maltese, William|Manning, Luisa|Senzer, Neil|Nemunaitis, John
PMID: 29851957
Journal: Trends Cancer. 2018 Jun;4(6):399-401.
Title: Mutant Kras Dosage and Chromothripsis: The Right Ingredients for a Pancreatic Cancer Catastrophe.
Author: Real, Francisco X|de Andres, Monica P
PMID: 29860982
Journal: Gastroenterology. 2018 Sep;155(3):892-908.e6.
Title: Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1.
Author: Nimmakayala, Rama Krishna|Seshacharyulu, Parthasarathy|Lakshmanan, Imayavaramban|Rachagani, Satyanarayana|Chugh, Seema|Karmakar, Saswati|Rauth, Sanchita|Vengoji, Raghupathy|Atri, Pranita|Talmon, Geoffrey A|Lele, Subodh M|Smith, Lynette M|Thapa, Ishwor|Bas
PMID: 29864419
Journal: Cancers (Basel). 2018 Jun 1;10(6). pii: cancers10060174.
Title: Signal-Targeted Therapies and Resistance Mechanisms in Pancreatic Cancer: Future Developments Reside in Proteomics.
Author: Cintas, Celia|Douche, Thibaut|Therville, Nicole|Arcucci, Silvia|Ramos-Delgado, Fernanda|Basset, Celine|Thibault, Benoit|Guillermet-Guibert, Julie
PMID: 29865155
Journal: Cancer Lett. 2018 Sep 1;431:171-181.
Title: A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment.
Author: Zhao, Xiao|Liu, Liang|Lang, Jiayan|Cheng, Keman|Wang, Yongwei|Li, Xueyan|Shi, Jian|Wang, Yanli|Nie, Guangjun
PMID: 29870774
Journal: Dis Model Mech. 2018 Jul 30;11(7). pii: dmm.034793.
Title: Orthotopic and heterotopic murine models of pancreatic cancer and their different responses to FOLFIRINOX chemotherapy.
Author: Erstad, Derek J|Sojoodi, Mozhdeh|Taylor, Martin S|Ghoshal, Sarani|Razavi, Allen A|Graham-O'Regan, Katherine A|Bardeesy, Nabeel|Ferrone, Cristina R|Lanuti, Michael|Caravan, Peter|Tanabe, Kenneth K|Fuchs, Bryan C
PMID: 29903803
Journal: Gastroenterology. 2018 Sep;155(3):880-891.e8.
Title: NFkappaB in Pancreatic Stellate Cells Reduces Infiltration of Tumors by Cytotoxic T Cells and Killing of Cancer Cells, via Up-regulation of CXCL12.
Author: Garg, Bharti|Giri, Bhuwan|Modi, Shrey|Sethi, Vrishketan|Castro, Iris|Umland, Oliver|Ban, Yuguang|Lavania, Shweta|Dawra, Rajinder|Banerjee, Sulagna|Vickers, Selwyn|Merchant, Nipun B|Chen, Steven Xi|Gilboa, Eli|Ramakrishnan, Sundaram|Saluja, Ashok|Dudeja, V
PMID: 29909021
Journal: Dev Cell. 2018 Jun 18;45(6):696-711.e8.
Title: Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer.
Author: Reichert, Maximilian|Bakir, Basil|Moreira, Leticia|Pitarresi, Jason R|Feldmann, Karin|Simon, Lauren|Suzuki, Kensuke|Maddipati, Ravikanth|Rhim, Andrew D|Schlitter, Anna M|Kriegsmann, Mark|Weichert, Wilko|Wirth, Matthias|Schuck, Kathleen|Schneider, Gunter|S
PMID: 29920275
Journal: Cell Physiol Biochem. 2018;47(4):1556-1564.
Title: Circulating Tumor DNA as a Sensitive Marker in Patients Undergoing Irreversible Electroporation for Pancreatic Cancer.
Author: Lin, Mao|Alnaggar, Mohammed|Liang, Shuzhen|Chen, Jibing|Xu, Kecheng|Dong, Shihua|Du, Duanming|Niu, Lizhi
PMID: 29940591
Journal: EMBO Mol Med. 2018 Aug;10(8). pii: emmm.201708741.
Title: Soluble stroma-related biomarkers of pancreatic cancer.
Author: Resovi, Andrea|Bani, Maria Rosa|Porcu, Luca|Anastasia, Alessia|Minoli, Lucia|Allavena, Paola|Cappello, Paola|Novelli, Francesco|Scarpa, Aldo|Morandi, Eugenio|Falanga, Anna|Torri, Valter|Taraboletti, Giulia|Belotti, Dorina|Giavazzi, Raffaella
PMID: 29941541
Journal: Nat Cell Biol. 2018 Jul;20(7):811-822.
Title: Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
Author: Patra, Krushna C|Kato, Yasutaka|Mizukami, Yusuke|Widholz, Sebastian|Boukhali, Myriam|Revenco, Iulia|Grossman, Elizabeth A|Ji, Fei|Sadreyev, Ruslan I|Liss, Andrew S|Screaton, Robert A|Sakamoto, Kei|Ryan, David P|Mino-Kenudson, Mari|Castillo, Carlos Fernand
PMID: 29941929
Journal: Front Immunol. 2018 Jun 21;9:1229.
Title: Deficiencies in Natural Killer Cell Numbers, Expansion, and Function at the Pre-Neoplastic Stage of Pancreatic Cancer by KRAS Mutation in the Pancreas of Obese Mice.
Author: Kaur, Kawaljit|Chang, Hui-Hua|Topchyan, Paytsar|Cook, Jessica Morgan|Barkhordarian, Andre|Eibl, Guido|Jewett, Anahid
PMID: 29977235
Journal: Invest New Drugs. 2018 Jul 12. pii: 10.1007/s10637-018-0635-4.
Title: The marine natural product Scalarin inhibits the receptor for advanced glycation end products (RAGE) and autophagy in the PANC-1 and MIA PaCa-2 pancreatic cancer cell lines.
Author: Guzman, Esther Amalia|Pitts, Tara Peterson|Diaz, Maria Cristina|Wright, Amy Elizabeth
PMID: 29998364
Journal: Cancer Biother Radiopharm. 2018 Jul 13.
Title: Expression of miRNA-143 in Pancreatic Cancer and Its Clinical Significance.
Author: Xu, Bo|Liu, Jia|Xiang, Xin|Liu, Shunhai|Zhong, Pingyong|Xie, Fei|Mou, Tinggang|Lai, Liang
PMID: 30004802
Journal: Mol Oncol. 2018 Jul 16.
Title: S100A10, a novel biomarker in pancreatic ductal adenocarcinoma.
Author: Bydoun, Moamen|Sterea, Andra|Liptay, Henry|Uzans, Andrea|Huang, Weei-Yuarn|Rodrigues, Gloria J|Weaver, Ian C G|Gu, Hong|Waisman, David M
PMID: 30009399
Journal: J Biol Chem. 2018 Sep 7;293(36):13989-14000.
Title: Transcriptional regulation of O-GlcNAc homeostasis is disrupted in pancreatic cancer.
Author: Qian, Kevin|Wang, Simeng|Fu, Minnie|Zhou, Jinfeng|Singh, Jay Prakash|Li, Min-Dian|Yang, Yunfan|Zhang, Kaisi|Wu, Jing|Nie, Yongzhan|Ruan, Hai-Bin|Yang, Xiaoyong
PMID: 30037904
Journal: J Exp Clin Cancer Res. 2018 Jul 24;37(1):166.
Title: Transgelin-2 is a novel target of KRAS-ERK signaling involved in the development of pancreatic cancer.
Author: Sun, Yan|Peng, Wenfang|He, Weiwei|Luo, Man|Chang, Guilin|Shen, Jiping|Zhao, Xiaoping|Hu, Yu
PMID: 30041673
Journal: Surg Case Rep. 2018 Jul 24;4(1):80.
Title: Medullary carcinoma of the pancreas radiologically followed up as a cystic lesion for 9 years: a case report and review of the literature.
Author: Yago, Akikazu|Furuya, Mitsuko|Mori, Ryutaro|Yabushita, Yasuhiro|Sawada, Yu|Kumamoto, Takafumi|Matsuyama, Ryusei|Shimizu, Michio|Endo, Itaru
PMID: 30043132
Journal: J Pathol. 2018 Jul 30.
Title: Serotonin uptake is required for Rac1 activation in Kras-induced acinar-to-ductal metaplasia in the pancreas.
Author: Saponara, Enrica|Visentin, Michele|Baschieri, Francesco|Seleznik, Gitta|Martinelli, Paola|Esposito, Irene|Buschmann, Johanna|Chen, Rong|Parrotta, Rossella|Borgeaud, Nathalie|Bombardo, Marta|Malagola, Ermanno|Caflisch, Amedeo|Farhan, Hesso|Graf, Rolf|Sonda
PMID: 30058725
Journal: Oncogene. 2018 Jul 30. pii: 10.1038/s41388-018-0390-1.
Title: GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine.
Author: Ferro, R|Adamska, A|Lattanzio, R|Mavrommati, I|Edling, C E|Arifin, S A|Fyffe, C A|Sala, G|Sacchetto, L|Chiorino, G|De Laurenzi, V|Piantelli, M|Sansom, O J|Maffucci, T|Falasca, M
PMID: 30061636
Journal: Mol Cancer Ther. 2018 Jul 31. pii: 1535-7163.MCT-17-1142.
Title: Concurrent HER or PI3K Inhibition Potentiates the Antitumor Effect of the ERK Inhibitor Ulixertinib in Preclinical Pancreatic Cancer Models.
Author: Jiang, Hongmei|Xu, Mai|Li, Lin|Grierson, Patrick|Dodhiawala, Paarth|Highkin, Maureen|Zhang, Daoxiang|Li, Qiong|Wang-Gillam, Andrea|Lim, Kian-Huat
PMID: 30065098
Journal: Sci Rep. 2018 Aug 2;8(1):11631.
Title: Utility of targeted deep sequencing for detecting circulating tumor DNA in pancreatic cancer patients.
Author: Park, Gahee|Park, Joo Kyung|Son, Dae-Soon|Shin, Seung-Ho|Kim, Yeon Jeong|Jeon, Hyo-Jeong|Lee, Jae|Park, Woong-Yang|Lee, Kwang Hyuck|Park, Donghyun
PMID: 30072705
Journal: Theranostics. 2018 Jun 13;8(14):3824-3840.
Title: Targeting S1PR1/STAT3 loop abrogates desmoplasia and chemosensitizes pancreatic cancer to gemcitabine.
Author: Lankadasari, Manendra Babu|Aparna, Jayasekharan S|Mohammed, Sabira|James, Shirley|Aoki, Kazunori|Binu, Valsalakumari S|Nair, Sindhu|Harikumar, Kuzhuvelil B
PMID: 30083262
Journal: Arch Pathol Lab Med. 2018 Aug 8.
Title: A Highly Verified Assay for KRAS Mutation Detection in Tissue and Plasma of Lung, Colorectal, and Pancreatic Cancer.
Author: Li, Jing|Gan, Stephanie|Blair, Alan|Min, Kyungji|Rehage, Taraneh|Hoeppner, Corey|Halait, Harkanwal|Brophy, Victoria H
PMID: 30088781
Journal: Dev Cell. 2018 Aug 20;46(4):441-455.e8.
Title: PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism.
Author: Li, Changfeng|Zhang, Ying|Cheng, Xing|Yuan, Hua|Zhu, Shan|Liu, Jiao|Wen, Qirong|Xie, Yangchun|Liu, Jinbao|Kroemer, Guido|Klionsky, Daniel J|Lotze, Michael T|Zeh, Herbert J|Kang, Rui|Tang, Daolin
PMID: 30100261
Journal: Cell Mol Gastroenterol Hepatol. 2018 May 26;6(2):223-224.
Title: Beyond Kras: MYC Rules in Pancreatic Cancer.
Author: Korc, Murray
PMID: 30105283
Journal: Surg Case Rep. 2018 Aug 16;4(1):96.
Title: Intrapancreatic recurrence of intraductal tubulopapillary neoplasm (ITPN) 16 years after the initial surgery for noninvasive ITPN: a case report.
Author: Saeki, Kiyoshi|Miyasaka, Yoshihiro|Ohishi, Yoshihiro|Yamamoto, Takeo|Matsuda, Ryota|Mochidome, Naoki|Mori, Yasuhisa|Nakata, Kohei|Ohtsuka, Takao|Ishigami, Kousei|Minoda, Yosuke|Koga, Yutaka|Oda, Yoshinao|Nakamura, Masafumi
PMID: 30116990
Journal: Theranostics. 2018 Jul 5;8(15):4033-4049.
Title: Pharmacokinetics and biodistribution of polymeric micelles containing miRNA and small-molecule drug in orthotopic pancreatic tumor-bearing mice.
Author: Kumar, Virender|Mundra, Vaibhav|Peng, Yang|Wang, Yingzhe|Tan, Chalet|Mahato, Ram I
PMID: 30128034
Journal: Genes Dev. 2018 Sep 1;32(17-18):1175-1187.
Title: STAT3 is a master regulator of epithelial identity and KRAS-driven tumorigenesis.
Author: D'Amico, Stephen|Shi, Jiaqi|Martin, Benjamin L|Crawford, Howard C|Petrenko, Oleksi|Reich, Nancy C
PMID: 30135074
Journal: Biomaterials. 2018 Nov;183:20-29.
Title: Overhang molecular beacons encapsulated in tethered cationic lipoplex nanoparticles for detection of single-point mutation in extracellular vesicle-associated RNAs.
Author: Hu, Jiaming|Kwak, Kwang Joo|Shi, Junfeng|Yu, Bohao|Sheng, Yan|Lee, Ly James
PMID: 30145409
Journal: Oncology. 2018 Aug 27:1-10.
Title: Pancreatic Cancer Cell Fraction Estimation in a DNA Sample.
Author: Ishihara, Hiroki|Yamashita, Satoshi|Amano, Ryosuke|Kimura, Kenjiro|Hirakawa, Kosei|Ueda, Takako|Murakami, Yoshiki|Tamori, Akihiro|Tanabe, Kazunari|Kawada, Norifumi|Hagihara, Atsushi|Ushijima, Toshikazu
PMID: 30149376
Journal: Cancer Res. 2018 Aug 28. pii: 0008-5472.CAN-18-0634.
Title: Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer.
Author: Nagathihalli, Nagaraj S|Castellanos, Jason|Lamichhane, Purushottam|Messaggio, Fanuel|Shi, Chanjuan|Dai, Xizi|Rai, Priyamvada|Chen, Xi|VanSaun, Michael N|Merchant, Nipun B
PMID: 30154150
Journal: Oncotarget. 2018 Aug 3;9(60):31771-31786.
Title: Liver metastasis of pancreatic cancer: the hepatic microenvironment impacts differentiation and self-renewal capacity of pancreatic ductal epithelial cells.
Author: Knaack, Hendrike|Lenk, Lennart|Philipp, Lisa-Marie|Miarka, Lauritz|Rahn, Sascha|Viol, Fabrice|Hauser, Charlotte|Egberts, Jan-Hendrik|Gundlach, Jan-Paul|Will, Olga|Tiwari, Sanjay|Mikulits, Wolfgang|Schumacher, Udo|Hengstler, Jan G|Sebens, Susanne
PMID: 30167093
Journal: World J Gastroenterol. 2018 Sep 7;24(33):3709-3723.
Title: p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation.
Author: Wang, Kai|Baldwin, Graham S|Nikfarjam, Mehrdad|He, Hong
PMID: 30197477
Journal: Nutrients. 2018 Sep 12;10(9). pii: nu10091289.
Title: Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway.
Author: Ding, Yongzeng|Mullapudi, Bhargava|Torres, Carolina|Mascarinas, Emman|Mancinelli, Georgina|Diaz, Andrew M|McKinney, Ronald|Barron, Morgan|Schultz, Michelle|Heiferman, Michael|Wojtanek, Mireille|Adrian, Kevin|DeCant, Brian|Rao, Sambasiva|Ouellette, Michel|
PMID: 30213082
Journal: Oncotarget. 2018 Aug 28;9(67):32736-32750.
Title: PKCiota and YAP1 are crucial in promoting pancreatic tumorigenesis.
Author: Wang, Peipei|Wei, Dapeng|Zhang, Hongmei|Chen, Jiao|Zhang, Dingding|Ganapathy, Suthakar|Isakson, Pauline|Chen, Changyan|Zhu, Tongbo
PMID: 30214681
Journal: Cancer Lett. 2018 Sep 11;438:174-186.
Title: KRAS targeting antibody synergizes anti-cancer activity of gemcitabine against pancreatic cancer.
Author: Kang, Yeo Wool|Lee, Ji Eun|Jung, Kyung Hee|Son, Mi Kwon|Shin, Seung-Min|Kim, Soo Jung|Fang, Zhenghuan|Yan, Hong Hua|Park, Jung Hee|Han, Boreum|Cheon, Min Ji|Woo, Min Gyu|Lim, Joo Han|Kim, Yong-Sung|Hong, Soon-Sun
PMID: 30217561
Journal: Int J Oncol. 2018 Sep 13.
Title: Establishment of a noncoding RNAomics screening platform for the regulation of KRAS in pancreatic cancer by RNA sequencing.
Author: Zhang, Li|Yu, Shuangni|Wang, Cuiping|Jia, Congwei|Lu, Zhaohui|Chen, Jie
PMID: 30221677
Journal: Eur J Pharm Sci. 2018 Sep 14;125:39-53.
Title: Porphyrins to restrict progression of pancreatic cancer by stabilizing KRAS G-quadruplex: In silico, in vitro and in vivo validation of anticancer strategy.
Author: Pattanayak, Rudradip|Barua, Atish|Das, Amlan|Chatterjee, Tanima|Pathak, Adrija|Choudhury, Pritha|Sen, Srikanta|Saha, Prosenjit|Bhattacharyya, Maitree
PMID: 30223034
Journal: Gene. 2018 Sep 15;679:328-334.
Title: Prognostic value of circulating cell-free DNA in patients with pancreatic cancer: A systemic review and meta-analysis.
Author: Chen, Linyan|Zhang, Yi|Cheng, Yuan|Zhang, Dan|Zhu, Sha|Ma, Xuelei
PMID: 30227250
Journal: Pathobiology. 2018 Sep 18:1-6.
Title: Early Loss of Forkhead Transcription Factor, O Subgroup, Member 1 Protein in the Development of Pancreatic Ductal Adenocarcinoma.
Author: Al-Zoughbi, Wael|Schauer, Silvia|Pichler, Martin|Hoefler, Gerald
PMID: 30227407
Journal: Clin Cancer Res. 2018 Sep 18. pii: 1078-0432.CCR-18-1485.
Title: A PET Imaging Strategy for Interrogating Target Engagement and Oncogene Status in Pancreatic Cancer.
Author: Henry, Kelly E|Dacek, Megan M|Dilling, Thomas R|Caen, Jonathan D|Fox, Ian L|Evans, Michael J|Lewis, Jason S
PMID: 30228208
Journal: J Pathol. 2018 Sep 19.
Title: Primordial germ cells as a potential shared cell of origin for mucinous cystic neoplasms of the pancreas and mucinous ovarian tumors.
Author: Elias, Kevin M|Tsantoulis, Petros|Tille, Jean-Christophe|Vitonis, Allison|Doyle, Leona A|Hornick, Jason L|Kaya, Gurkan|Barnes, Laurent|Cramer, Daniel W|Puppa, Giacomo|Stuckelberger, Sarah|Hooda, Jagmohan|Dietrich, Pierre-Yves|Goggins, Michael|Kerr, Candac
PMID: 30229909
Journal: Gastroenterology. 2018 Sep 18. pii: S0016-5085(18)35006-6.
Title: Circulating Nucleic Acids Associate with Outcomes of Patients with Pancreatic Cancer.
Author: Bernard, Vincent|Kim, Dong U|San Lucas, F Anthony|Castillo, Jonathan|Allenson, Kelvin|Mulu, Feven C|Stephens, Bret M|Huang, Jonathan|Semaan, Alexander|Guerrero, Paola A|Kamyabi, Nabiollah|Zhao, Jun|Hurd, Mark W|Koay, Eugene J|Taniguchi, Cullen|Herman, Jos
PMID: 30240661
Journal: J Clin Med. 2018 Sep 20;7(10). pii: jcm7100295.
Title: The Combination of MiRNA-196b, LCN2, and TIMP1 is a Potential Set of Circulating Biomarkers for Screening Individuals at Risk for Familial Pancreatic Cancer.
Author: Bartsch, Detlef K|Gercke, Norman|Strauch, Konstantin|Wieboldt, Ronja|Matthai, Elvira|Wagner, Vinona|Rospleszcz, Susanne|Schafer, Agnes|Franke, Frederike S|Mintziras, Ioannis|Bauer, Christian|Grote, Tobias|Figiel, Jens|Di Fazio, Pietro|Burchert, Andreas|Re
PMID: 30241369
Journal: Sci Rep. 2018 Sep 21;8(1):14211.
Title: Chemotherapy payload of anti-insoluble fibrin antibody-drug conjugate is released specifically upon binding to fibrin.
Author: Fuchigami, Hirobumi|Manabe, Shino|Yasunaga, Masahiro|Matsumura, Yasuhiro
PMID: 30242282
Journal: Autophagy. 2018 Sep 25.
Title: Mitochondrial Quality Control Mediated by PINK1 and PRKN: Links to Iron Metabolism and Tumor Immunity.
Author: Kang, Rui|Xie, Yangchun|Zeh, Herbert J|Klionsky, Daniel J|Tang, Daolin
PMID: 30252570
Journal: Mol Cancer Ther. 2018 Sep 25. pii: 1535-7163.MCT-18-0082.
Title: Cyclooxygenase-2 Influences Response to Co-Targeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers.
Author: Maust, Joel D|Frankowski-McGregor, Christy L|Bankhead, Armand|Simeone, Diane M|Sebolt-Leopold, Judith S
PMID: 30254182
Journal: Cancer Biol Ther. 2018 Sep 27:1-10.
Title: Combined inhibition of the PI3K/mTOR/MEK pathway induces Bim/Mcl-2-regulated apoptosis in pancreatic cancer cells.
Author: Burmi, Rajpal S|Maginn, Elaina N|Gabra, Hani|Stronach, Euan A|Wasan, Harpreet S
PMID: 30261145
Journal: Clin Cancer Res. 2018 Sep 28. pii: 1078-0432.CCR-18-0814.
Title: Host IDO2 gene status influences tumor progression and radiotherapy response in KRAS-driven sporadic pancreatic cancers.
Author: Nevler, Avinoam|Muller, Alexander J|Sutanto-Ward, Erika|DuHadaway, James B|Nagatomo, Kei|Londin, Eric|O'Hayer, Kevin|Cozzitorto, Joseph A|Lavu, Harish|Yeo, Theresa P|Curtis, Mark T|Villatoro, Tatiana|Leiby, Benjamin E|Mandik-Nayak, Laura|Winter, Jordan M|
PMID: 30266763
Journal: J Cancer. 2018 Sep 8;9(18):3394-3399.
Title: Antitumor activity of sorafenib plus CDK4/6 inhibitor in pancreatic patient derived cell with KRAS mutation.
Author: Lee, Taehyang|Kim, Kyung|Lee, Jeeyun|Park, Se Hoon|Park, Young Suk|Lim, Ho Yeong|Kang, Won Ki|Park, Joon Oh|Kim, Seung Tae
PMID: 30271501
Journal: Front Oncol. 2018 Sep 19;8:384.
Title: KRAS RENAISSANCE(S) in Tumor Infiltrating B Cells in Pancreatic Cancer.
Author: Meng, Qingda|Valentini, Davide|Rao, Martin|Maeurer, Markus
PMID: 30283732
Journal: Oncol Res Treat. 2018;41(10):619-625.
Title: Targeting Defects in the Cellular DNA Damage Response for the Treatment of Pancreatic Ductal Adenocarcinoma.
Author: Schmitt, Anna|Feldmann, Georg|Zander, Thomas|Reinhardt, H Christian
PMID: 30286473
Journal: Gastroenterology. 2018 Oct 5. pii: S0016-5085(18)35087-X.
Title: Levels of the Autophagy Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice.
Author: Gorgulu, Kivanc|Diakopoulos, Kalliope N|Ai, Jiaoyu|Schoeps, Benjamin|Kabacaoglu, Derya|Karpathaki, Angeliki-Faidra|Ciecielski, Katrin J|Kaya-Aksoy, Ezgi|Ruess, Dietrich A|Berninger, Alexandra|Kowalska, Marlena|Stevanovic, Marija|Wormann, Sonja M|Wartmann,
PMID: 30296435
Journal: Mol Cancer Ther. 2018 Oct 9. pii: 1535-7163.MCT-17-1298.
Title: Monitoring tumor burden in response to FOLFIRINOX chemotherapy via profiling circulating cell-free DNA in pancreatic cancer.
Author: Wei, Tao|Zhang, Qi|Li, Xiang|Su, Wei|Li, Guogang|Ma, Tao|Gao, Shunliang|Lou, Jianying|Que, Risheng|Zheng, Lei|Bai, Xueli|Liang, Tingbo
PMID: 30301865
Journal: Cancer Chemother Pharmacol. 2018 Oct 10. pii: 10.1007/s00280-018-3699-0.
Title: Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-Kras(G12D/+);Tp53(R172H/+) (KPC) mice, a genetically engineered model of pancreatic cancer.
Author: Vilimas, Tomas|Wang, Amy Q|Patnaik, Samarjit|Hughes, Emma A|Singleton, Marc D|Knotts, Zachary|Li, Dandan|Frankowski, Kevin|Schlomer, Jerome J|Guerin, Theresa M|Springer, Stephanie|Drennan, Catherine|Dextras, Christopher|Wang, Chen|Gilbert, Debra|Southall,
PMID: 30306263
Journal: RNA Biol. 2018 Oct 11:1-13.
Title: MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells.
Author: Ferino, Annalisa|Miglietta, Giulia|Picco, Raffaella|Vogel, Stefan|Wengel, Jesper|Xodo, Luigi E
PMID: 30306823
Journal: Gut. 2018 Oct 12. pii: gutjnl-2017-315490.
Title: SWI/SNF component ARID1A restrains pancreatic neoplasia formation.
Author: Wang, Sam C|Nassour, Ibrahim|Xiao, Shu|Zhang, Shuyuan|Luo, Xin|Lee, Jeon|Li, Lin|Sun, Xuxu|Nguyen, Liem H|Chuang, Jen-Chieh|Peng, Lan|Daigle, Scott|Shen, Jeanne|Zhu, Hao
PMID: 30315093
Journal: Nanotheranostics. 2018 Aug 25;2(4):371-386.
Title: Functionalized MoS2 Nanosheets as Multi-Gene Delivery Vehicles for In Vivo Pancreatic Cancer Therapy.
Author: Yin, Feng|Anderson, Tommy|Panwar, Nishtha|Zhang, Kang|Tjin, Swee Chuan|Ng, Beng Koon|Yoon, Ho Sup|Qu, Junle|Yong, Ken-Tye
PMID: 30324083
Journal: Nanotheranostics. 2018 Sep 5;2(4):387-402.
Title: A Scalable Method for Squalenoylation and Assembly of Multifunctional (64)Cu-Labeled Squalenoylated Gemcitabine Nanoparticles.
Author: Tucci, Samantha T|Seo, Jai W|Kakwere, Hamilton|Kheirolomoom, Azadeh|Ingham, Elizabeth S|Mahakian, Lisa M|Tam, Sarah|Tumbale, Spencer|Baikoghli, Mo|Cheng, R Holland|Ferrara, Katherine W
PMID: 30324084
Journal: Curr Protoc Pharmacol. 2018 Oct 16:e48.
Title: Murine Models of Pancreatitis Leading to the Development of Pancreatic Cancer.
Author: Leal, Ana S|Liby, Karen T
PMID: 30325112
Journal: Ann Oncol. 2018 Oct 21. pii: 5139593.
Title: Repeated mutKRAS ctDNA measurements represent a novel and promising tool for early response prediction and therapy monitoring in advanced pancreatic cancer.
Author: Kruger, S|Heinemann, V|Ross, C|Diehl, F|Nagel, D|Ormanns, S|Liebmann, S|Prinz-Bravin, I|Westphalen, C B|Haas, M|Jung, A|Kirchner, T|von Bergwelt-Baildon, M|Boeck, S|Holdenrieder, S
PMID: 30346475
Journal: IUBMB Life. 2018 Oct 22.
Title: Ubiquitin-independent, Proteasome-mediated targeted degradation of KRAS in pancreatic adenocarcinoma cells using an engineered ornithine decarboxylase/antizyme system.
Author: Ma, Yihui|Xu, Jingjing|Huang, Pei|Bai, Xue|Gao, Hanqing
PMID: 30347501
Journal: Virchows Arch. 2018 Oct 23. pii: 10.1007/s00428-018-2476-0.
Title: EVI1 expression is associated with aggressive behavior in intrahepatic cholangiocarcinoma.
Author: Tanaka, Mariko|Shibahara, Junji|Ishikawa, Shumpei|Ushiku, Tetsuo|Morikawa, Teppei|Shinozaki-Ushiku, Aya|Hayashi, Akimasa|Misumi, Kento|Tanaka, Atsushi|Katoh, Hiroto|Sakuma, Kei|Kokudo, Takashi|Inagaki, Yoshinori|Arita, Junichi|Sakamoto, Yoshihiro|Hasegawa
PMID: 30349952
Journal: Cancer Res. 2018 Oct 24. pii: 0008-5472.CAN-18-1968.
Title: PIN1 maintains redox balance via the c-Myc/NRF2 axis to counteract Kras-induced mitochondrial respiratory injury in pancreatic cancer cells.
Author: Liang, Chen|Shi, Si|Liu, Mingyang|Qin, Yi|Meng, Qingcai|Hua, Jie|Ji, Shunrong|Zhang, Yuqing|Yang, Jingxuan|Xu, Jin|Ni, Quanxing|Li, Min|Yu, Xianjun
PMID: 30355620
Journal: Pathol Oncol Res. 2018 Oct 25. pii: 10.1007/s12253-018-0490-9.
Title: Comparison of Native Aspirates and Cytological Smears Obtained by EUS-Guided Biopsies for Effective DNA/RNA Marker Testing in Pancreatic Cancer.
Author: Benesova, Lucie|Halkova, Tereza|Bunganic, Bohus|Belsanova, Barbora|Zavoral, Miroslav|Traboulsi, Eva|Minarik, Marek
PMID: 30361898
Journal: J Vis Exp. 2018 Oct 9;(140).
Title: Immunophenotyping of Orthotopic Homograft (Syngeneic) of Murine Primary KPC Pancreatic Ductal Adenocarcinoma by Flow Cytometry.
Author: An, Xiaoyu|Ouyang, Xuesong|Zhang, Hui|Li, Tingting|Huang, Yu-Yang|Li, Zhiyuan|Zhou, Demin|Li, Qi-Xang
PMID: 30371656
Journal: Cancer Metab. 2018 Oct 23;6:17.
Title: PKM2 is not required for pancreatic ductal adenocarcinoma.
Author: Hillis, Alissandra L|Lau, Allison N|Devoe, Camille X|Dayton, Talya L|Danai, Laura V|Di Vizio, Dolores|Vander Heiden, Matthew G
PMID: 30386596