Primary Site >> Pancreatic Cancer

Gene >> KDR

Journal: Int J Cancer. 2000 Jan 1;85(1):27-34.
Title: Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer.
Author: Itakura, J|Ishiwata, T|Shen, B|Kornmann, M|Korc, M
PMID: 10585578
Journal: Gastroenterology. 2000 Nov;119(5):1358-72.
Title: De novo expression of vascular endothelial growth factor in human pancreatic cancer: evidence for an autocrine mitogenic loop.
Author: von Marschall, Z|Cramer, T|Hocker, M|Burde, R|Plath, T|Schirner, M|Heidenreich, R|Breier, G|Riecken, E O|Wiedenmann, B|Rosewicz, S
PMID: 11054395
Journal: Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4605-10. Epub 2001 Mar 27.
Title: Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer.
Author: Kuo, C J|Farnebo, F|Yu, E Y|Christofferson, R|Swearingen, R A|Carter, R|von Recum, H A|Yuan, J|Kamihara, J|Flynn, E|D'Amato, R|Folkman, J|Mulligan, R C
PMID: 11274374
Journal: Histol Histopathol. 2001 Apr;16(2):359-75.
Title: Expression of VEGF-C and activation of its receptors VEGFR-2 and VEGFR-3 in trophoblast.
Author: Dunk, C|Ahmed, A
PMID: 11332691
Journal: Surgery. 2002 Nov;132(5):857-65.
Title: Adenovirus-mediated delivery of a soluble form of the VEGF receptor Flk1 delays the growth of murine and human pancreatic adenocarcinoma in mice.
Author: Tseng, Jennifer F|Farnebo, Filip A|Kisker, Oliver|Becker, Christian M|Kuo, Calvin J|Folkman, Judah|Mulligan, Richard C
PMID: 12464871
Journal: Cancer Res. 2003 Sep 15;63(18):5978-91.
Title: CEP-7055: a novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical models.
Author: Ruggeri, Bruce|Singh, Jasbir|Gingrich, Diane|Angeles, Thelma|Albom, Mark|Yang, Shi|Chang, Hong|Robinson, Candy|Hunter, Kathryn|Dobrzanski, Pawel|Jones-Bolin, Susan|Pritchard, Sonya|Aimone, Lisa|Klein-Szanto, Andres|Herbert, Jean-Marc|Bono, Francoise|Schae
PMID: 14522925
Journal: Cancer. 2004 Nov 15;101(10):2341-50.
Title: Pancreatic carcinoma cells express neuropilins and vascular endothelial growth factor, but not vascular endothelial growth factor receptors.
Author: Li, Min|Yang, Hui|Chai, Hong|Fisher, William E|Wang, Xiaoping|Brunicardi, F Charles|Yao, Qizhi|Chen, Changyi
PMID: 15476280
Journal: Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):678-89.
Title: Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668.
Author: Davis, Darren W|Takamori, Ryan|Raut, Chandrajit P|Xiong, Henry Q|Herbst, Roy S|Stadler, Walter M|Heymach, John V|Demetri, George D|Rashid, Asif|Shen, Yu|Wen, Sijin|Abbruzzese, James L|McConkey, David J
PMID: 15701856
Journal: Curr Cancer Drug Targets. 2005 May;5(3):171-93.
Title: Molecularly targeted therapy for gastrointestinal cancer.
Author: Wiedmann, Marcus W|Caca, Karel
PMID: 15892618
Journal: Neoplasia. 2005 Jul;7(7):696-704.
Title: Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice.
Author: Yokoi, Kenji|Kim, Sun-Jin|Thaker, Premal|Yazici, Sertac|Nam, Do-Hyun|He, Junqin|Sasaki, Takamitsu|Chiao, Paul J|Sclabas, Guido M|Abbruzzese, James L|Hamilton, Stanley R|Fidler, Isaiah J
PMID: 16026649
Journal: Cancer Res. 2005 Nov 15;65(22):10371-80.
Title: Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model.
Author: Yokoi, Kenji|Sasaki, Takamitsu|Bucana, Corazon D|Fan, Dominic|Baker, Cheryl H|Kitadai, Yasuhiko|Kuwai, Toshio|Abbruzzese, James L|Fidler, Isaiah J
PMID: 16288027
Journal: Cancer. 2006 Apr 15;106(8):1677-84.
Title: Vascular endothelial growth factor, FLT-1, and FLK-1 analysis in a pancreatic cancer tissue microarray.
Author: Chung, Gina G|Yoon, Harry H|Zerkowski, Maciej P|Ghosh, Sriparna|Thomas, Laurie|Harigopal, Malini|Charette, Lori A|Salem, Ronald R|Camp, Robert L|Rimm, David L|Burtness, Barbara A
PMID: 16532435
Journal: Drug Resist Updat. 2006 Feb-Apr;9(1-2):1-18. Epub 2006 Apr 18.
Title: Tyrosine kinase inhibitors and gemcitabine: new treatment options in pancreatic cancer?
Author: Kleespies, Axel|Jauch, Karl-Walter|Bruns, Christiane J
PMID: 16621676
Journal: Clin Cancer Res. 2006 Apr 15;12(8):2628-33.
Title: Roles of nitric oxide synthase inhibition and vascular endothelial growth factor receptor-2 inhibition on vascular morphology and function in an in vivo model of pancreatic cancer.
Author: Camp, E Ramsay|Yang, Anthony|Liu, Wenbiao|Fan, Fan|Somcio, Ray|Hicklin, Daniel J|Ellis, Lee M
PMID: 16638876
Journal: Biochem Biophys Res Commun. 2006 Jun 23;345(1):292-301. Epub 2006 May 2.
Title: Regulation of vascular endothelial growth factor receptor-2 expression in pancreatic cancer cells by Sp proteins.
Author: Higgins, Kelly J|Abdelrahim, Maen|Liu, Shengxi|Yoon, Kyungsil|Safe, Stephen
PMID: 16678129
Journal: Ann Surg Oncol. 2006 Aug;13(8):1145-55.
Title: Selective blockade of vascular endothelial growth factor receptor 2 with an antibody against tumor-derived vascular endothelial growth factor controls the growth of human pancreatic adenocarcinoma xenografts.
Author: Holloway, Shane E|Beck, Adam W|Shivakumar, Latha|Shih, Jessica|Fleming, Jason B|Brekken, Rolf A
PMID: 16791450
Journal: Br J Cancer. 2007 Oct 22;97(8):1116-23. Epub 2007 Sep 25.
Title: Molecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines.
Author: Hurt, E M|Thomas, S B|Peng, B|Farrar, W L
PMID: 17895890
Journal: Int J Radiat Oncol Biol Phys. 2008 Jul 1;71(3):873-9.
Title: SU11248 (sunitinib) sensitizes pancreatic cancer to the cytotoxic effects of ionizing radiation.
Author: Cuneo, Kyle C|Geng, Ling|Fu, Allie|Orton, Darren|Hallahan, Dennis E|Chakravarthy, Anuradha Bapsi
PMID: 18514780
Journal: Cancer Res. 2008 Jun 1;68(11):4340-6.
Title: Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice.
Author: Dineen, Sean P|Lynn, Kristi D|Holloway, Shane E|Miller, Andrew F|Sullivan, James P|Shames, David S|Beck, Adam W|Barnett, Carlton C|Fleming, Jason B|Brekken, Rolf A
PMID: 18519694
Journal: Mol Cancer Ther. 2008 Nov;7(11):3509-18.
Title: Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes.
Author: Lang, Sven A|Schachtschneider, Philipp|Moser, Christian|Mori, Akira|Hackl, Christina|Gaumann, Andreas|Batt, David|Schlitt, Hans J|Geissler, Edward K|Stoeltzing, Oliver
PMID: 19001434
Journal: Clin Cancer Res. 2008 Nov 15;14(22):7272-83.
Title: Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3.
Author: Hu-Lowe, Dana D|Zou, Helen Y|Grazzini, Maren L|Hallin, Max E|Wickman, Grant R|Amundson, Karin|Chen, Jeffrey H|Rewolinski, David A|Yamazaki, Shinji|Wu, Ellen Y|McTigue, Michele A|Murray, Brion W|Kania, Robert S|O'Connor, Patrick|Shalinsky, David R|Bender,
PMID: 19010843
Journal: BMC Cancer. 2008 Nov 27;8:352.
Title: The Adnectin CT-322 is a novel VEGF receptor 2 inhibitor that decreases tumor burden in an orthotopic mouse model of pancreatic cancer.
Author: Dineen, Sean P|Sullivan, Laura A|Beck, Adam W|Miller, Andrew F|Carbon, Juliet G|Mamluk, Roni|Wong, Henry|Brekken, Rolf A
PMID: 19038046
Journal: Transl Oncol. 2008 Dec;1(4):195-201.
Title: Enzastaurin, an inhibitor of PKCbeta, Enhances Antiangiogenic Effects and Cytotoxicity of Radiation against Endothelial Cells.
Author: Spalding, Aaron C|Zeitlin, Benjamin D|Wilder-Romans, Kari|Davis, Mary E|Nor, Jacques E|Lawrence, Theodore S|Ben-Josef, Edgar
PMID: 19043530
Journal: Gan To Kagaku Ryoho. 2008 Nov;35(12):2271-3.
Title: [A phase I study of combination-therapy with gemcitabine and epitope peptides derived from human vascular endothelial growth factor receptor for unresectable or recurrent pancreas cancer].
Author: Kim, Dal Ho|Shiozawa, Shunichi|Usui, Takebumi|Yoshimatsu, Kazuhiko|Otani, Taisuke|Tsunoda, Takuya|Nakamura, Yusuke|Ogawa, Kenji
PMID: 19106593
Journal: Biologics. 2008 Dec;2(4):707-15.
Title: Small molecule tyrosine kinase inhibitors in pancreatic cancer.
Author: Gupta, Sachin|El-Rayes, Bassel F
PMID: 19707451
Journal: J Cell Physiol. 2009 Apr;219(1):209-18.
Title: The Ape-1/Ref-1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: therapeutic implications in tumor angiogenesis.
Author: Zou, Gang-Ming|Karikari, Collins|Kabe, Yasuaki|Handa, Hiroshi|Anders, Robert A|Maitra, Anirban
PMID: 19097035
Journal: Gan To Kagaku Ryoho. 2009 Feb;36(2):187-92.
Title: [Treatments of epithelial ovarian cancer by histologic subtype].
Author: Sugiyama, Toru|Kumagai, Seisuke|Hatayama, Shinya
PMID: 19223734
Journal: Anticancer Res. 2009 Jun;29(6):1999-2007.
Title: Prioritization of EGFR/IGF-IR/VEGFR2 combination targeted therapies utilizing cancer models.
Author: Tonra, James R|Corcoran, Erik|Deevi, Dhanvanthri S|Steiner, Philipp|Kearney, Jessica|Li, Huiling|Ludwig, Dale L|Zhu, Zhenping|Witte, Larry|Surguladze, David|Hicklin, Daniel J
PMID: 19528458
Journal: Mol Cancer Ther. 2009 Jul;8(7):1761-71.
Title: Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts.
Author: Roland, Christina L|Dineen, Sean P|Lynn, Kristi D|Sullivan, Laura A|Dellinger, Michael T|Sadegh, Leila|Sullivan, James P|Shames, David S|Brekken, Rolf A
PMID: 19567820
Journal: Nat Rev Clin Oncol. 2009 Oct;6(10):569-79.
Title: An overview of small-molecule inhibitors of VEGFR signaling.
Author: Ivy, S Percy|Wick, Jeannette Y|Kaufman, Bennett M
PMID: 19736552
Journal: Cancer Sci. 2010 Feb;101(2):433-9.
Title: Phase I clinical trial using peptide vaccine for human vascular endothelial growth factor receptor 2 in combination with gemcitabine for patients with advanced pancreatic cancer.
Author: Miyazawa, Motoki|Ohsawa, Ryuji|Tsunoda, Takuya|Hirono, Seiko|Kawai, Manabu|Tani, Masaji|Nakamura, Yusuke|Yamaue, Hiroki
PMID: 19930156
Journal: Cancer Sci. 2010 Jun;101(6):1529-35.
Title: Significance of phospho-vascular endothelial growth factor receptor-2 expression in pancreatic cancer.
Author: Doi, Yosuke|Yashiro, Masakazu|Yamada, Nobuya|Amano, Ryosuke|Ohira, Go|Komoto, Masahiro|Noda, Satoru|Kashiwagi, Shinichiro|Kato, Yukihiro|Fuyuhiro, Yuhiko|Hirakawa, Kosei
PMID: 20367641
Journal: Mol Imaging Biol. 2010 Dec;12(6):570-5.
Title: Bioluminescence imaging of angiogenesis in a murine orthotopic pancreatic cancer model.
Author: Angst, Eliane|Chen, Monica|Mojadidi, Michelle|Hines, O Joe|Reber, Howard A|Eibl, Guido
PMID: 20376570
Journal: Mol Pharmacol. 2010 Aug;78(2):226-36.
Title: Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a.
Author: Jutooru, Indira|Chadalapaka, Gayathri|Abdelrahim, Maen|Basha, Md Riyaz|Samudio, Ismael|Konopleva, Marina|Andreeff, Michael|Safe, Stephen
PMID: 20488920
Journal: Chemotherapy. 2010;56(4):303-12.
Title: Synergistic cytotoxicity and molecular interaction on drug targets of sorafenib and gemcitabine in human pancreas cancer cells.
Author: Ricciardi, Simona|Mey, Valentina|Nannizzi, Sara|Pasqualetti, Giuseppe|Crea, Francesco|Del Tacca, Mario|Danesi, Romano
PMID: 20714148
Journal: Neoplasia. 2010 Oct;12(10):797-806.
Title: Specific targeting of tumor endothelial cells by a shiga-like toxin-vascular endothelial growth factor fusion protein as a novel treatment strategy for pancreatic cancer.
Author: Hotz, Birgit|Backer, Marina V|Backer, Joseph M|Buhr, Heinz-J|Hotz, Hubert G
PMID: 20927318
Journal: Cancer Res. 2010 Nov 1;70(21):8812-21.
Title: Nuclear receptor COUP-TFII controls pancreatic islet tumor angiogenesis by regulating vascular endothelial growth factor/vascular endothelial growth factor receptor-2 signaling.
Author: Qin, Jun|Chen, Xinpu|Yu-Lee, Li-Yuan|Tsai, Ming-Jer|Tsai, Sophia Y
PMID: 20978203
Journal: Toxins (Basel). 2010 Sep;2(9):2242-57.
Title: SLT-VEGF reduces lung metastases, decreases tumor recurrence, and improves survival in an orthotopic melanoma model.
Author: Ackerman, Rachel|Backer, Joseph M|Backer, Marina|Skariah, Sini|Hamby, Carl V
PMID: 22069683
Journal: Radiology. 2011 Mar;258(3):804-11.
Title: Tumor angiogenic marker expression levels during tumor growth: longitudinal assessment with molecularly targeted microbubbles and US imaging.
Author: Deshpande, Nirupama|Ren, Ying|Foygel, Kira|Rosenberg, Jarrett|Willmann, Jurgen K
PMID: 21339349
Journal: Neoplasia. 2011 Mar;13(3):217-29.
Title: Irinotecan synergistically enhances the antiproliferative and proapoptotic effects of axitinib in vitro and improves its anticancer activity in vivo.
Author: Canu, Bastianina|Fioravanti, Anna|Orlandi, Paola|Di Desidero, Teresa|Ali, Greta|Fontanini, Gabriella|Di Paolo, Antonello|Del Tacca, Mario|Danesi, Romano|Bocci, Guido
PMID: 21390185
Journal: Clin Cancer Res. 2011 Aug 15;17(16):5299-310.
Title: Brivanib, a dual FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF inhibition.
Author: Allen, Elizabeth|Walters, Ian B|Hanahan, Douglas
PMID: 21622725
Journal: Mol Cancer Ther. 2011 Nov;10(11):2157-67.
Title: Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer.
Author: Taeger, Johannes|Moser, Christian|Hellerbrand, Claus|Mycielska, Maria E|Glockzin, Gabriel|Schlitt, Hans J|Geissler, Edward K|Stoeltzing, Oliver|Lang, Sven A
PMID: 21885862
Journal: PLoS One. 2011;6(10):e25799.
Title: Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-alpha/VEGF/Rho-GTPases: pivotal role of STAT-3.
Author: Boreddy, Srinivas Reddy|Sahu, Ravi P|Srivastava, Sanjay K
PMID: 22016776
Journal: Gan To Kagaku Ryoho. 2011 Nov;38(12):1903-5.
Title: [The development of a novel cancer vaccine using Peptide vaccine for patients with advanced pancreatic cancer].
Author: Miyazawa, Motoki|Yamaue, Hiroki
PMID: 22202233
Journal: Invest New Drugs. 2012 Feb;30(1):382-6.
Title: Gemcitabine plus sorafenib in patients with advanced pancreatic cancer: a phase II trial of the University of Chicago Phase II Consortium.
Author: Kindler, Hedy Lee|Wroblewski, Kristen|Wallace, James A|Hall, Michael J|Locker, Gershon|Nattam, Sreenivasa|Agamah, Edem|Stadler, Walter M|Vokes, Everett E
PMID: 20803052
Journal: Ann Surg Oncol. 2012 Jul;19 Suppl 3:S464-74.
Title: High expression of delta-like ligand 4 predicts poor prognosis after curative resection for pancreatic cancer.
Author: Chen, Hai-Tao|Cai, Quan-Cai|Zheng, Jian-Ming|Man, Xiao-Hua|Jiang, Hui|Song, Bin|Jin, Gang|Zhu, Wei|Li, Zhao-Shen
PMID: 21822553
Journal: Ann Surg Oncol. 2012 Aug;19(8):2733-43.
Title: VEGF-A/VEGFR-2 signaling plays an important role for the motility of pancreas cancer cells.
Author: Doi, Yosuke|Yashiro, Masakazu|Yamada, Nobuya|Amano, Ryosuke|Noda, Satoru|Hirakawa, Kosei
PMID: 22207048
Journal: Clin Cancer Res. 2012 May 15;18(10):2838-49.
Title: Molecular profiling of pancreatic neuroendocrine tumors in sporadic and Von Hippel-Lindau patients.
Author: Speisky, Daniela|Duces, Aurelie|Bieche, Ivan|Rebours, Vinciane|Hammel, Pascal|Sauvanet, Alain|Richard, Stephane|Bedossa, Pierre|Vidaud, Michel|Murat, Arnaud|Niccoli, Patricia|Scoazec, Jean-Yves|Ruszniewski, Philippe|Couvelard, Anne
PMID: 22461457
Journal: Eur J Clin Invest. 2012 Oct;42(10):1061-7.
Title: Novel dual inhibitors of vascular endothelial growth factor and VEGFR2 receptor.
Author: Nguyen, Jennifer P|Frost, Chelsea D|Lane, Meghan L|Skelton Iv, William P|Skelton, Michelle|Vesely, David L
PMID: 22703300
Journal: PLoS One. 2012;7(8):e42146.
Title: Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis.
Author: Lin, Sheng-Zhang|Wei, Wei-Tian|Chen, Hui|Chen, Kang-Jie|Tong, Hong-Fei|Wang, Zhao-Hong|Ni, Zhong-Lin|Liu, Hai-Bin|Guo, Hong-Chun|Liu, Dian-Lei
PMID: 22876305
Journal: BMC Cancer. 2012 Aug 20;12:361.
Title: Double-blind, placebo-controlled first in human study to investigate an oral vaccine aimed to elicit an immune reaction against the VEGF-Receptor 2 in patients with stage IV and locally advanced pancreatic cancer.
Author: Niethammer, Andreas G|Lubenau, Heinz|Mikus, Gerd|Knebel, Philipp|Hohmann, Nicolas|Leowardi, Christine|Beckhove, Philipp|Akhisaroglu, Mustafa|Ge, Yingzi|Springer, Marco|Grenacher, Lars|Buchler, Markus W|Koch, Moritz|Weitz, Jurgen|Haefeli, Walter E|Schmitz-
PMID: 22906006
Journal: J Pharmacol Exp Ther. 2012 Dec;343(3):617-27.
Title: Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families.
Author: Glaser, Keith B|Li, Junling|Marcotte, Patrick A|Magoc, Terrance J|Guo, Jun|Reuter, David R|Tapang, Paul|Wei, Ru-Qi|Pease, Lori J|Bui, Mai H|Chen, Zehan|Frey, Robin R|Johnson, Eric F|Osterling, Donald J|Olson, Amanda M|Bouska, Jennifer J|Luo, Yanping|Curti
PMID: 22935731
Journal: Pancreas. 2013 Apr;42(3):411-21.
Title: Molecular markers for novel therapeutic strategies in pancreatic endocrine tumors.
Author: Gilbert, Judith A|Adhikari, Laura J|Lloyd, Ricardo V|Halfdanarson, Thorvardur R|Muders, Michael H|Ames, Matthew M
PMID: 23211371
Journal: Ann Oncol. 2013 May;24(5):1282-90.
Title: VEGFR-2, CXCR-2 and PAR-1 germline polymorphisms as predictors of survival in pancreatic carcinoma.
Author: Uzunoglu, F G|Kolbe, J|Wikman, H|Gungor, C|Bohn, B A|Nentwich, M F|Reeh, M|Konig, A M|Bockhorn, M|Kutup, A|Mann, O|Izbicki, J R|Vashist, Y K
PMID: 23293110
Journal: Br J Cancer. 2013 Mar 19;108(5):1052-60.
Title: Biomarker results from the AVADO phase 3 trial of first-line bevacizumab plus docetaxel for HER2-negative metastatic breast cancer.
Author: Miles, D W|de Haas, S L|Dirix, L Y|Romieu, G|Chan, A|Pivot, X|Tomczak, P|Provencher, L|Cortes, J|Delmar, P R|Scherer, S J
PMID: 23422754
Journal: J Cell Mol Med. 2013 Jun;17(6):792-9.
Title: An intensified systemic trafficking of bone marrow-derived stem/progenitor cells in patients with pancreatic cancer.
Author: Starzynska, Teresa|Dabkowski, Krzysztof|Blogowski, Wojciech|Zuba-Surma, Ewa|Budkowska, Marta|Salata, Daria|Dolegowska, Barbara|Marlicz, Wojciech|Lubikowski, Jerzy|Ratajczak, Mariusz Z
PMID: 23672538
Journal: Pancreatology. 2013 Jul-Aug;13(4):415-22.
Title: Efficacy and safety profile of combining agents against epidermal growth factor receptor or vascular endothelium growth factor receptor with gemcitabine-based chemotherapy in patients with advanced pancreatic cancer: a meta-analysis.
Author: Tian, Wei|Ding, Wenping|Kim, Sungkyoung|Xu, Xiaoxing|Pan, Minggui|Chen, Siyu
PMID: 23890141
Journal: Cell Signal. 2013 Dec;25(12):2587-603.
Title: A novel epidermal growth factor receptor-signaling platform and its targeted translation in pancreatic cancer.
Author: Gilmour, Alanna M|Abdulkhalek, Samar|Cheng, Timothy S W|Alghamdi, Farah|Jayanth, Preethi|O'Shea, Leah K|Geen, Olivia|Arvizu, Luis A|Szewczuk, Myron R
PMID: 23993964
Journal: PLoS One. 2013 Sep 4;8(9):e72480.
Title: Therapeutic targeting of tumor growth and angiogenesis with a novel anti-S100A4 monoclonal antibody.
Author: Hernandez, Jose Luis|Padilla, Laura|Dakhel, Sheila|Coll, Toni|Hervas, Rosa|Adan, Jaume|Masa, Marc|Mitjans, Francesc|Martinez, Josep Maria|Coma, Silvia|Rodriguez, Laura|Noe, Veronique|Ciudad, Carlos J|Blasco, Francesc|Messeguer, Ramon
PMID: 24023743
Journal: PLoS One. 2013 Sep 9;8(9):e73940.
Title: DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer.
Author: Sureban, Sripathi M|May, Randal|Qu, Dongfeng|Weygant, Nathaniel|Chandrakesan, Parthasarathy|Ali, Naushad|Lightfoot, Stan A|Pantazis, Panayotis|Rao, Chinthalapally V|Postier, Russell G|Houchen, Courtney W
PMID: 24040120
Journal: Oncoimmunology. 2013 Nov 1;2(11):e27010.
Title: Immunological responses to a multi-peptide vaccine targeting cancer-testis antigens and VEGFRs in advanced pancreatic cancer patients.
Author: Okuyama, Ryuji|Aruga, Atsushi|Hatori, Takashi|Takeda, Kazuyoshi|Yamamoto, Masakazu
PMID: 24498547
Journal: Br J Cancer. 2014 Jan 21;110(2):320-9.
Title: Enhanced FGFR signalling predisposes pancreatic cancer to the effect of a potent FGFR inhibitor in preclinical models.
Author: Zhang, H|Hylander, B L|LeVea, C|Repasky, E A|Straubinger, R M|Adjei, A A|Ma, W W
PMID: 24327018
Journal: PLoS One. 2014 Jan 9;9(1):e82209.
Title: A phase I, dose-finding study of sorafenib in combination with gemcitabine and radiation therapy in patients with unresectable pancreatic adenocarcinoma: a Grupo Espanol Multidisciplinario en Cancer Digestivo (GEMCAD) study.
Author: Aparicio, Jorge|Garcia-Mora, Carmen|Martin, Marta|Petriz, Ma Lourdes|Feliu, Jaime|Sanchez-Santos, Ma Elena|Ayuso, Juan Ramon|Fuster, David|Conill, Carlos|Maurel, Joan
PMID: 24416138
Journal: Cancer Immunol Immunother. 2014 May;63(5):479-89.
Title: P53, hTERT, WT-1, and VEGFR2 are the most suitable targets for cancer vaccine therapy in HLA-A24 positive pancreatic adenocarcinoma.
Author: Terashima, Takeshi|Mizukoshi, Eishiro|Arai, Kuniaki|Yamashita, Tatsuya|Yoshida, Mariko|Ota, Hajime|Onishi, Ichiro|Kayahara, Masato|Ohtsubo, Koushiro|Kagaya, Takashi|Honda, Masao|Kaneko, Shuichi
PMID: 24633336
Journal: PLoS One. 2014 Apr 2;9(4):e92161.
Title: Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic hedgehog pathways.
Author: Huang, Minzhao|Tang, Su-Ni|Upadhyay, Ghanshyam|Marsh, Justin L|Jackman, Christopher P|Shankar, Sharmila|Srivastava, Rakesh K
PMID: 24694877
Journal: Cancer Lett. 2014 Aug 28;351(1):151-61.
Title: XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism.
Author: Sureban, Sripathi M|May, Randal|Weygant, Nathaniel|Qu, Dongfeng|Chandrakesan, Parthasarathy|Bannerman-Menson, Eddie|Ali, Naushad|Pantazis, Panayotis|Westphalen, Christoph B|Wang, Timothy C|Houchen, Courtney W
PMID: 24880079
Journal: Cancer Sci. 2014 Sep;105(9):1116-23.
Title: Expression of platelet-derived growth factor receptor beta is maintained by Prox1 in lymphatic endothelial cells and is required for tumor lymphangiogenesis.
Author: Miyazaki, Hideki|Yoshimatsu, Yasuhiro|Akatsu, Yuichi|Mishima, Koichi|Fukayama, Masashi|Watabe, Tetsuro|Miyazono, Kohei
PMID: 24981766
Journal: Cell Rep. 2014 Aug 7;8(3):696-706.
Title: Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade.
Author: Rigamonti, Nicolo|Kadioglu, Ece|Keklikoglou, Ioanna|Wyser Rmili, Celine|Leow, Ching Ching|De Palma, Michele
PMID: 25088418
Journal: Pathol Res Pract. 2014 Dec;210(12):901-8.
Title: Serous neoplasms of the pancreas share many, but not all aspects of their microvascular and angiogenic profile with low-grade clear cell renal cell carcinomas.
Author: Liszka, Lukasz|Pajak, Jacek|Golka, Dariusz
PMID: 25155377
Journal: World J Gastroenterol. 2014 Oct 7;20(37):13343-68.
Title: Gene therapy in pancreatic cancer.
Author: Liu, Si-Xue|Xia, Zhong-Sheng|Zhong, Ying-Qiang
PMID: 25309069
Journal: Radiology. 2015 Mar;274(3):790-9.
Title: Vascular endothelial growth factor receptor type 2-targeted contrast-enhanced US of pancreatic cancer neovasculature in a genetically engineered mouse model: potential for earlier detection.
Author: Pysz, Marybeth A|Machtaler, Steven B|Seeley, E Scott|Lee, John J|Brentnall, Teresa A|Rosenberg, Jarrett|Tranquart, Francois|Willmann, Jurgen K
PMID: 25322341
Journal: Virchows Arch. 2015 Feb;466(2):237-41.
Title: Basaloid carcinoma of the pancreas--clinicopathological presentation and oncogenetic snapshot of a rare entity.
Author: Szasz, A Marcell|Szirtes, Ildiko|Tihanyi, Balazs|Barkaszi, Bernadett|Baranyai, Zsolt|Tihanyi, Tibor|Harsanyi, Laszlo|Timar, Jozsef|Kulka, Janina
PMID: 25432630
Journal: Mol Cancer Ther. 2015 Feb;14(2):407-18.
Title: A preclinical evaluation of SKLB261, a multikinase inhibitor of EGFR/Src/VEGFR2, as a therapeutic agent against pancreatic cancer.
Author: Pan, Youli|Zheng, Mingwu|Zhong, Lei|Yang, Jiao|Zhou, Shu|Qin, Ya|Xiang, Rong|Chen, Yuzong|Yang, Sheng-Yong
PMID: 25519702
Journal: Oncotarget. 2015 Jun 20;6(17):14940-52.
Title: Foretinib inhibits angiogenesis, lymphangiogenesis and tumor growth of pancreatic cancer in vivo by decreasing VEGFR-2/3 and TIE-2 signaling.
Author: Chen, Hsiu-Mei|Tsai, Chia-Hua|Hung, Wen-Chun
PMID: 25909285
Journal: Oncotarget. 2015 Jul 20;6(20):17981-8000.
Title: Identification of TAX2 peptide as a new unpredicted anti-cancer agent.
Author: Jeanne, Albin|Sick, Emilie|Devy, Jerome|Floquet, Nicolas|Belloy, Nicolas|Theret, Louis|Boulagnon-Rombi, Camille|Diebold, Marie-Daniele|Dauchez, Manuel|Martiny, Laurent|Schneider, Christophe|Dedieu, Stephane
PMID: 26046793
Journal: Cancer Genet. 2015 Jul-Aug;208(7-8):374-81.
Title: Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines.
Author: Boora, Ganesh K|Kanwar, Rahul|Kulkarni, Amit A|Pleticha, Josef|Ames, Matthew|Schroth, Gary|Beutler, Andreas S|Banck, Michaela S
PMID: 26087898
Journal: Oncoimmunology. 2015 Mar 16;4(4):e1001217.
Title: Anti-angiogenic activity of VXM01, an oral T-cell vaccine against VEGF receptor 2, in patients with advanced pancreatic cancer: A randomized, placebo-controlled, phase 1 trial.
Author: Schmitz-Winnenthal, Friedrich H|Hohmann, Nicolas|Niethammer, Andreas G|Friedrich, Tobias|Lubenau, Heinz|Springer, Marco|Breiner, Klaus M|Mikus, Gerd|Weitz, Jurgen|Ulrich, Alexis|Buechler, Markus W|Pianka, Frank|Klaiber, Ulla|Diener, Markus|Leowardi, Chris
PMID: 26137397
Journal: Medicine (Baltimore). 2015 Aug;94(32):e1303.
Title: An Attempt to Evaluate Selected Aspects of "Bone-Fat Axis" Function in Healthy Individuals and Patients With Pancreatic Cancer.
Author: Blogowski, Wojciech|Dolegowska, Katarzyna|Deskur, Anna|Dolegowska, Barbara|Starzynska, Teresa
PMID: 26266370
Journal: Clin Exp Metastasis. 2015 Dec;32(8):799-817.
Title: Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors.
Author: Moen, Ingrid|Gebre, Matthew|Alonso-Camino, Vanesa|Chen, Debbie|Epstein, David|McDonald, Donald M
PMID: 26445848
Journal: Transl Oncogenomics. 2015 Nov 23;7(Suppl 1):13-31.
Title: c-Met as a Target for Personalized Therapy.
Author: Garajova, Ingrid|Giovannetti, Elisa|Biasco, Guido|Peters, Godefridus J
PMID: 26628860
Journal: Rom J Intern Med. 2015 Jul-Sep;53(3):199-208.
Title: VEGF Expression in Pancreatic Cancer and Other Malignancies: A Review of the Literature.
Author: Costache, M I|Ioana, Mihai|Iordache, Sevastita|Ene, D|Costache, Cornelia Alexandra|Saftoiu, A
PMID: 26710495
Journal: Anticancer Agents Med Chem. 2016;16(6):771-80.
Title: Multiple Pharmacological Properties of a Novel Parthenin Analog P16 as Evident by its Cytostatic and Antiangiogenic Potential Against Pancreatic Adenocarcinoma PANC -1 Cells.
Author: Goswami, Akshra|Shah, Bhahwal Ali|Batra, Navneet|Kumar, Ajay|Guru, Santosh Kumar|Bhushan, Shashi|Malik, Fayaz Ahmad|Joshi, Amit|Singh, Jagtar
PMID: 26299660
Journal: Acta Biochim Biophys Sin (Shanghai). 2016 Jan;48(1):27-38.
Title: RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
Author: Fang, Bingliang
PMID: 26350096
Journal: Gastroenterology. 2016 Feb;150(2):513-25.e10.
Title: Inhibition of Tumor Growth and Metastasis in Pancreatic Cancer Models by Interference With CD44v6 Signaling.
Author: Matzke-Ogi, Alexandra|Jannasch, Katharina|Shatirishvili, Marine|Fuchs, Beatrix|Chiblak, Sara|Morton, Jennifer|Tawk, Bouchra|Lindner, Thomas|Sansom, Owen|Alves, Frauke|Warth, Arne|Schwager, Christian|Mier, Walter|Kleeff, Jorg|Ponta, Helmut|Abdollahi, Amir|
PMID: 26597578
Journal: Eur J Med Chem. 2016 Apr 13;112:20-32.
Title: The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity.
Author: Newton, Rebecca|Bowler, Katherine A|Burns, Emily M|Chapman, Philip J|Fairweather, Emma E|Fritzl, Samantha J R|Goldberg, Kristin M|Hamilton, Niall M|Holt, Sarah V|Hopkins, Gemma V|Jones, Stuart D|Jordan, Allan M|Lyons, Amanda J|Nikki March, H|McDonald, Nei
PMID: 26874741
Journal: Oncotarget. 2016 Apr 19;7(16):21775-85.
Title: DSGOST inhibits tumor growth by blocking VEGF/VEGFR2-activated angiogenesis.
Author: Choi, Hyeong Sim|Lee, Kangwook|Kim, Min Kyoung|Lee, Kang Min|Shin, Yong Cheol|Cho, Sung-Gook|Ko, Seong-Gyu
PMID: 26967562
Journal: Oncotarget. 2016 May 31;7(22):32969-79.
Title: SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2.
Author: Choi, Hyeong Sim|Kim, Min Kyoung|Lee, Kangwook|Lee, Kang Min|Choi, Youn Kyung|Shin, Yong Cheol|Cho, Sung-Gook|Ko, Seong-Gyu
PMID: 27105528
Journal: Oncotarget. 2016 Jul 26;7(30):48265-48279.
Title: The pancreatic niche inhibits the effectiveness of sunitinib treatment of pancreatic cancer.
Author: Martinez-Bosch, Neus|Guerrero, Pedro Enrique|Moreno, Mireia|Jose, Anabel|Iglesias, Mar|Munne-Collado, Jessica|Anta, Hector|Gibert, Joan|Orozco, Carlos Alberto|Vinaixa, Judith|Fillat, Cristina|Vinals, Francesc|Navarro, Pilar
PMID: 27374084
Journal: Anticancer Res. 2016 Oct;36(10):5025-5030.
Title: Antiangiogenic Therapy in Pancreatic Neuroendocrine Tumors.
Author: Capozzi, Monica|VON Arx, Claudia|DE Divitiis, Chiara|Ottaiano, Alessandro|Tatangelo, Fabiana|Romano, Giovanni Maria|Tafuto, Salvatore
PMID: 27798861
Journal: Cancer Sci. 2017 Jan;108(1):73-80.
Title: Phase II clinical trial of peptide cocktail therapy for patients with advanced pancreatic cancer: VENUS-PC study.
Author: Suzuki, Nobuaki|Hazama, Shoichi|Iguchi, Haruo|Uesugi, Kazuhiro|Tanaka, Hiroaki|Hirakawa, Kosei|Aruga, Atsushi|Hatori, Takashi|Ishizaki, Hidenobu|Umeda, Yuzo|Fujiwara, Toshiyoshi|Ikemoto, Tetsuya|Shimada, Mitsuo|Yoshimatsu, Kazuhiko|Shimizu, Ryoichi|Hayash
PMID: 27783849
Journal: Int J Cancer. 2017 Feb 15;140(4):973-982.
Title: Phase II clinical trial using novel peptide cocktail vaccine as a postoperative adjuvant treatment for surgically resected pancreatic cancer patients.
Author: Miyazawa, Motoki|Katsuda, Masahiro|Maguchi, Hiroyuki|Katanuma, Akio|Ishii, Hiroshi|Ozaka, Masato|Yamao, Kenji|Imaoka, Hiroshi|Kawai, Manabu|Hirono, Seiko|Okada, Ken-Ichi|Yamaue, Hiroki
PMID: 27861852
Journal: J Control Release. 2017 Jan 10;245:1-14.
Title: Triple-amiRNA VEGFRs inhibition in pancreatic cancer improves the efficacy of chemotherapy through EMT regulation.
Author: Huang, Jianfei|Mei, Haijun|Tang, Zhiyuan|Li, Jieying|Zhang, Xiaojing|Lu, Yixiang|Huang, Fang|Jin, Qin|Wang, Zhiwei
PMID: 27889393
Journal: Int J Mol Sci. 2017 Feb 17;18(2). pii: ijms18020439.
Title: Determination of VEGFR-2 (KDR) 604A>G Polymorphism in Pancreatic Disorders.
Author: Padureanu, Vlad|Boldeanu, Mihail Virgil|Streata, Ioana|Cucu, Mihai Gabriel|Silosi, Isabela|Boldeanu, Lidia|Bogdan, Maria|Enescu, Anca Stefania|Fortofoiu, Maria|Enescu, Aurelia|Dumitrescu, Elena Madalina|Alexandru, Dragos|Surlin, Valeriu Marian|Fortofoiu,
PMID: 28218664
Journal: Expert Opin Emerg Drugs. 2017 Mar;22(1):77-86.
Title: Emerging protein kinase inhibitors for treating pancreatic cancer.
Author: Furuse, Junji|Nagashima, Fumio
PMID: 28253828
Journal: Expert Opin Emerg Drugs. 2017 Mar;22(1):39-51.
Title: Emerging antibodies for the treatment of pancreatic cancer.
Author: Andrikou, Kalliopi|Peterle, Chiara|Pipitone, Stefania|Salati, Massimiliano|Cascinu, Stefano
PMID: 28253833
Journal: Lancet Oncol. 2017 Apr;18(4):486-499.
Title: Vandetanib plus gemcitabine versus placebo plus gemcitabine in locally advanced or metastatic pancreatic carcinoma (ViP): a prospective, randomised, double-blind, multicentre phase 2 trial.
Author: Middleton, Gary|Palmer, Daniel H|Greenhalf, William|Ghaneh, Paula|Jackson, Richard|Cox, Trevor|Evans, Anthony|Shaw, Victoria E|Wadsley, Jonathan|Valle, Juan W|Propper, David|Wasan, Harpreet|Falk, Stephen|Cunningham, David|Coxon, Fareeda|Ross, Paul|Madhusu
PMID: 28259610
Journal: Pathol Res Pract. 2017 Jun;213(6):639-642.
Title: CPEB4 immunohistochemical expression is associated to prognosis in stage IV colorectal carcinoma.
Author: Cortes-Guiral, D|Pastor-Iodate, C|Diaz Del Arco, C|Del Puerto-Nevado, L|Fernandez-Acenero, M J
PMID: 28551384
Journal: Naunyn Schmiedebergs Arch Pharmacol. 2017 Nov;390(11):1125-1134.
Title: A marginal anticancer effect of regorafenib on pancreatic carcinoma cells in vitro, ex vivo, and in vivo.
Author: Mayer, Barbara|Karakhanova, Svetlana|Bauer, Nathalie|Liu, Li|Zhu, Yifan|Philippov, Pavel P|Werner, Jens|Bazhin, Alexandr V
PMID: 28779210
Journal: Nat Commun. 2017 Sep 15;8(1):552.
Title: Identification of the S100 fused-type protein hornerin as a regulator of tumor vascularity.
Author: Gutknecht, Michael F|Seaman, Marc E|Ning, Bo|Cornejo, Daniel Auger|Mugler, Emily|Antkowiak, Patrick F|Moskaluk, Christopher A|Hu, Song|Epstein, Frederick H|Kelly, Kimberly A
PMID: 28916756
Journal: Cell Death Dis. 2018 Feb 12;9(2):210.
Title: Association of cytosolic sialidase Neu2 with plasma membrane enhances Fas-mediated apoptosis by impairing PI3K-Akt/mTOR-mediated pathway in pancreatic cancer cells.
Author: Nath, Shalini|Mandal, Chhabinath|Chatterjee, Uttara|Mandal, Chitra
PMID: 29434218
Journal: Oncoimmunology. 2018 Jan 16;7(4):e1303584.
Title: A phase 1 trial extension to assess immunologic efficacy and safety of prime-boost vaccination with VXM01, an oral T cell vaccine against VEGFR2, in patients with advanced pancreatic cancer.
Author: Schmitz-Winnenthal, Friedrich H|Hohmann, Nicolas|Schmidt, Thomas|Podola, Lilli|Friedrich, Tobias|Lubenau, Heinz|Springer, Marco|Wieckowski, Sebastien|Breiner, Klaus M|Mikus, Gerd|Buchler, Markus W|Keller, Anne-Valerie|Koc, Ruhan|Springfeld, Christoph|Kneb
PMID: 29632710
Journal: Oncotarget. 2018 Apr 20;9(30):21613-21627.
Title: Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: a systematic review.
Author: Sheahan, Anjali V|Biankin, Andrew V|Parish, Christopher R|Khachigian, Levon M
PMID: 29765563
Journal: Onco Targets Ther. 2018 May 9;11:2685-2698.
Title: Traditional Chinese medicine Astragalus polysaccharide enhanced antitumor effects of the angiogenesis inhibitor apatinib in pancreatic cancer cells on proliferation, invasiveness, and apoptosis.
Author: Wu, Jun|Wang, Jing|Su, Qiang|Ding, Wei|Li, Teng|Yu, Junxian|Cao, Bangwei
PMID: 29785118
Journal: J Pathol. 2018 Jul 20.
Title: VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival.
Author: Morin, Eric|Sjoberg, Elin|Tjomsland, Vegard|Testini, Chiara|Lindskog, Cecilia|Franklin, Oskar|Sund, Malin|Ohlund, Daniel|Kiflemariam, Sara|Sjoblom, Tobias|Claesson-Welsh, Lena
PMID: 30027561
Journal: Oncol Rep. 2018 Nov;40(5):3102-3111.
Title: Tanshinone IIA can inhibit MiaPaCa2 human pancreatic cancer cells by dual blockade of the Ras/Raf/MEK/ERK and PI3K/AKT/mTOR pathways.
Author: Su, Chin-Cheng
PMID: 30226540