Literatures

Primary Site >> Colorectal Cancer

Gene >> KDR

1.
Journal:	Cancer Res. 1993 Oct 1;53(19):4727-35.
Title:	Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract.
Author:	Brown, L F\|Berse, B\|Jackman, R W\|Tognazzi, K\|Manseau, E J\|Senger, D R\|Dvorak, H F
PMID:	8402650

2.
Journal:	J Clin Invest. 1995 Apr;95(4):1789-97.
Title:	Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis.
Author:	Warren, R S\|Yuan, H\|Matli, M R\|Gillett, N A\|Ferrara, N
PMID:	7535799

3.
Journal:	Cancer Res. 1995 Sep 15;55(18):3964-8.
Title:	Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer.
Author:	Takahashi, Y\|Kitadai, Y\|Bucana, C D\|Cleary, K R\|Ellis, L M
PMID:	7664263

4.
Journal:	Cancer Lett. 1997 Nov 11;119(2):227-35.
Title:	Association of vascular endothelial growth factor expression with tumor angiogenesis, survival and thymidine phosphorylase/platelet-derived endothelial cell growth factor expression in human colorectal cancer.
Author:	Amaya, H\|Tanigawa, N\|Lu, C\|Matsumura, M\|Shimomatsuya, T\|Horiuchi, T\|Muraoka, R
PMID:	9570376

5.
Journal:	Pathobiology. 1998;66(5):247-52.
Title:	Regulation of vascular endothelial growth factor receptor KDR in vitro by a soluble factor in confluent endothelial cells.
Author:	Liu, W\|Ellis, L M
PMID:	9732240

6.
Journal:	Am J Gastroenterol. 1999 Apr;94(4):1070-6.
Title:	Increased expression of angiogenic factors in human colonic angiodysplasia.
Author:	Junquera, F\|Saperas, E\|de Torres, I\|Vidal, M T\|Malagelada, J R
PMID:	10201485

7.
Journal:	Cell Res. 1999 Mar;9(1):11-25.
Title:	A novel gene delivery system targeting cells expressing VEGF receptors.
Author:	Li, J M\|Han, J S\|Huang, Y\|Tain, P K\|Qu, S M\|Yao, M\|Jiang, H Q\|Wan, D F\|Luo, J C\|Gu, C X\|Gu, J R
PMID:	10321685

8.
Journal:	Cancer Res. 1999 Nov 1;59(21):5412-6.
Title:	Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis.
Author:	Shaheen, R M\|Davis, D W\|Liu, W\|Zebrowski, B K\|Wilson, M R\|Bucana, C D\|McConkey, D J\|McMahon, G\|Ellis, L M
PMID:	10554007

9.
Journal:	Int J Cancer. 2000 Apr 15;86(2):174-81.
Title:	Vegf, Vegf-B, Vegf-C and their receptors KDR, FLT-1 and FLT-4 during the neoplastic progression of human colonic mucosa.
Author:	Andre, T\|Kotelevets, L\|Vaillant, J C\|Coudray, A M\|Weber, L\|Prevot, S\|Parc, R\|Gespach, C\|Chastre, E
PMID:	10738243

10.
Journal:	Am J Gastroenterol. 2000 Apr;95(4):1062-7.
Title:	Factors influencing tissue concentration of vascular endothelial growth factor in colorectal carcinoma.
Author:	Ono, T\|Miki, C
PMID:	10763960

11.
Journal:	Oncologist. 2000;5 Suppl 1:11-5.
Title:	Vascular endothelial growth factor in human colon cancer: biology and therapeutic implications.
Author:	Ellis, L M\|Takahashi, Y\|Liu, W\|Shaheen, R M
PMID:	10804085

12.
Journal:	Dis Colon Rectum. 2000 Jul;43(7):980-6.
Title:	Angiogenesis of liver metastases: role of sinusoidal endothelial cells.
Author:	Gervaz, P\|Scholl, B\|Mainguene, C\|Poitry, S\|Gillet, M\|Wexner, S
PMID:	10910247

13.
Journal:	Cancer. 2000 Aug 1;89(3):488-99.
Title:	Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases.
Author:	Bruns, C J\|Liu, W\|Davis, D W\|Shaheen, R M\|McConkey, D J\|Wilson, M R\|Bucana, C D\|Hicklin, D J\|Ellis, L M
PMID:	10931447

14.
Journal:	Int J Oncol. 2001 Feb;18(2):221-6.
Title:	Effects of an antibody to vascular endothelial growth factor receptor-2 on survival, tumor vascularity, and apoptosis in a murine model of colon carcinomatosis.
Author:	Shaheen, R M\|Tseng, W W\|Vellagas, R\|Liu, W\|Ahmad, S A\|Jung, Y D\|Reinmuth, N\|Drazan, K E\|Bucana, C D\|Hicklin, D J\|Ellis, L M
PMID:	11172585

15.
Journal:	Nihon Geka Gakkai Zasshi. 2001 May;102(5):381-4.
Title:	[Significance of angiogenesis and clinical application of anti-angiogenesis].
Author:	Takahashi, Y\|Mai, M
PMID:	11394000

16.
Journal:	Curr Opin Mol Ther. 2001 Aug;3(4):418-24.
Title:	Technology evaluation: IMC-1C11, ImClone Systems.
Author:	Hunt, S
PMID:	11525567

17.
Journal:	Curr Med Chem. 2001 Oct;8(12):1487-503.
Title:	Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents.
Author:	Owa, T\|Yoshino, H\|Yoshimatsu, K\|Nagasu, T
PMID:	11562278

18.
Journal:	Neoplasia. 2001 Sep-Oct;3(5):420-7.
Title:	VEGF-A, VEGF-C, and VEGF-D in colorectal cancer progression.
Author:	George, M L\|Tutton, M G\|Janssen, F\|Arnaout, A\|Abulafi, A M\|Eccles, S A\|Swift, R I
PMID:	11687953

19.
Journal:	Int J Clin Oncol. 2001 Oct;6(5):221-8.
Title:	Expression of vascular endothelial growth factor and its receptor KDR (kinase domain-containing receptor)/Flk-1 (fetal liver kinase-1) as prognostic factors in human colorectal cancer.
Author:	Harada, Y\|Ogata, Y\|Shirouzu, K
PMID:	11723743

20.
Journal:	Expert Opin Biol Ther. 2001 Jul;1(4):703-18.
Title:	VEGF antagonists.
Author:	Hasan, J\|Jayson, G C
PMID:	11727506

21.
Journal:	Cancer Res. 2002 Mar 15;62(6):1669-75.
Title:	Vascular endothelial growth factor-D expression is an independent prognostic marker for survival in colorectal carcinoma.
Author:	White, Jeff D\|Hewett, Peter W\|Kosuge, Dennis\|McCulloch, Thomas\|Enholm, Berndt C\|Carmichael, James\|Murray, J Clifford
PMID:	11912138

22.
Journal:	Oncogene. 2002 Apr 25;21(18):2896-900.
Title:	Enhanced expression of vascular endothelial growth factor (VEGF) plays a critical role in the tumor progression potential induced by simian virus 40 large T antigen.
Author:	Catalano, Alfonso\|Romano, Mario\|Martinotti, Stefano\|Procopio, Antonio
PMID:	11973650

23.
Journal:	Anticancer Res. 2002 May-Jun;22(3):1877-80.
Title:	Soluble FLT-1 is detectable in the sera of colorectal and breast cancer patients.
Author:	Kumar, Harish\|Heer, Kamal\|Greenman, John\|Kerin, Michael J\|Monson, John R T
PMID:	12168886

24.
Journal:	Nat Med. 2002 Dec;8(12):1369-75.
Title:	A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth.
Author:	Niethammer, Andreas G\|Xiang, Rong\|Becker, Jurgen C\|Wodrich, Harald\|Pertl, Ursula\|Karsten, Gabriele\|Eliceiri, Brian P\|Reisfeld, Ralph A
PMID:	12415261

25.
Journal:	Clin Cancer Res. 2003 Apr;9(4):1323-32.
Title:	A phase I study of anti-kinase insert domain-containing receptor antibody, IMC-1C11, in patients with liver metastases from colorectal carcinoma.
Author:	Posey, James A\|Ng, Thian C\|Yang, Baolian\|Khazaeli, M B\|Carpenter, Mark D\|Fox, Floyd\|Needle, Mike\|Waksal, Harlan\|LoBuglio, Albert F
PMID:	12684400

26.
Journal:	Clin Cancer Res. 2003 Apr;9(4):1546-56.
Title:	Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase.
Author:	Ciardiello, Fortunato\|Caputo, Rosa\|Damiano, Vincenzo\|Caputo, Roberta\|Troiani, Teresa\|Vitagliano, Donatella\|Carlomagno, Francesca\|Veneziani, Bianca Maria\|Fontanini, Gabriella\|Bianco, A Raffaele\|Tortora, Giampaolo
PMID:	12684431

27.
Journal:	J Pathol. 2003 Jun;200(2):183-94.
Title:	The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression.
Author:	Hanrahan, Vickie\|Currie, Margaret J\|Gunningham, Sarah P\|Morrin, Helen R\|Scott, Prudence A E\|Robinson, Bridget A\|Fox, Stephen B
PMID:	12754739

28.
Journal:	Int J Oncol. 2003 Aug;23(2):533-9.
Title:	Quantitative analysis of lymphangiogenic markers in human colorectal cancer.
Author:	Parr, C\|Jiang, W G
PMID:	12851706

29.
Journal:	Cancer Res. 2003 Sep 15;63(18):5978-91.
Title:	CEP-7055: a novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical models.
Author:	Ruggeri, Bruce\|Singh, Jasbir\|Gingrich, Diane\|Angeles, Thelma\|Albom, Mark\|Yang, Shi\|Chang, Hong\|Robinson, Candy\|Hunter, Kathryn\|Dobrzanski, Pawel\|Jones-Bolin, Susan\|Pritchard, Sonya\|Aimone, Lisa\|Klein-Szanto, Andres\|Herbert, Jean-Marc\|Bono, Francoise\|Schae
PMID:	14522925

30.
Journal:	Clin Cancer Res. 2004 Jan 15;10(2):739-50.
Title:	In vivo assessment of antiangiogenic activity of SU6668 in an experimental colon carcinoma model.
Author:	Marzola, Pasquina\|Degrassi, Anna\|Calderan, Laura\|Farace, Paolo\|Crescimanno, Caterina\|Nicolato, Elena\|Giusti, Anna\|Pesenti, Enrico\|Terron, Andrea\|Sbarbati, Andrea\|Abrams, Tinya\|Murray, Lesley\|Osculati, Francesco
PMID:	14760097

31.
Journal:	Clin Cancer Res. 2004 Jan 15;10(2):784-93.
Title:	Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy.
Author:	Ciardiello, Fortunato\|Bianco, Roberto\|Caputo, Roberta\|Caputo, Rosa\|Damiano, Vincenzo\|Troiani, Teresa\|Melisi, Davide\|De Vita, Ferdinando\|De Placido, Sabino\|Bianco, A Raffaele\|Tortora, Giampaolo
PMID:	14760102

32.
Journal:	Oncogene. 2004 Feb 26;23(8):1618-26.
Title:	Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor.
Author:	Morimoto, Alyssa M\|Tan, Nguyen\|West, Kristina\|McArthur, Grant\|Toner, Guy C\|Manning, William C\|Smolich, Beverly D\|Cherrington, Julie M
PMID:	14985702

33.
Journal:	J Hepatobiliary Pancreat Surg. 2004;11(3):164-70.
Title:	Expression of vascular endothelial growth factor and receptor flk-1 in colon cancer liver metastases.
Author:	Cheng, Jun\|Slavin, Richard E\|Gallagher, Jennifer A\|Zhu, Guojing\|Biehl, Thomas R\|Swanstrom, Lee L\|Hansen, Paul D
PMID:	15235888

34.
Journal:
Title:	(125)I-Vascular endothelial growth factor-121
Author:	Leung, Kam
PMID:	20641207

35.
Journal:
Title:	(111)In-Diethylenetriamine pentaacetic acid-bevacizumab
Author:	Leung, Kam
PMID:	20641545

36.
Journal:
Title:	Alexa Fluor 680-Bevacizumab
Author:	Leung, Kam
PMID:	20641728

37.
Journal:
Title:	(64)Cu-1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid-quantum dot-vascular endothelial growth factor
Author:	Zhang, Huiming
PMID:	20641777

38.
Journal:
Title:	(89)Zr-N-Succinyldesferrioxamine-bevacizumab
Author:	Leung, Kam
PMID:	20641842

39.
Journal:
Title:	(86)Y-CHX-A''-Diethylenetriamine pentaacetic acid-bevacizumab
Author:	Leung, Kam
PMID:	21433411

40.
Journal:
Title:	Anti-vascular endothelial growth factor polylactic acid-polyethylene glycol-poly-L-Lys/gadolinium-diethylenetriamine pentaacetic acid nanoparticles
Author:	Leung, Kam
PMID:	22812022

41.
Journal:
Title:	(64)Cu-1,4,7-Triazacyclononane-1,4,7-triacetic acid-p-isothiocyanatobenzyl-bevacizumab-IRDye 800CW
Author:	Leung, Kam
PMID:	23534080

42.
Journal:	Ann Oncol. 2005 Apr;16(4):558-65. Epub 2005 Feb 10.
Title:	Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials.
Author:	Drevs, J\|Zirrgiebel, U\|Schmidt-Gersbach, C I M\|Mross, K\|Medinger, M\|Lee, L\|Pinheiro, J\|Wood, J\|Thomas, A L\|Unger, C\|Henry, A\|Steward, W P\|Laurent, D\|Lebwohl, D\|Dugan, M\|Marme, D
PMID:	15705616

43.
Journal:	Oncogene. 2005 Apr 14;24(16):2647-53.
Title:	Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells.
Author:	Fan, Fan\|Wey, Jane S\|McCarty, Marya F\|Belcheva, Anna\|Liu, Wenbiao\|Bauer, Todd W\|Somcio, Ray J\|Wu, Yan\|Hooper, Andrea\|Hicklin, Daniel J\|Ellis, Lee M
PMID:	15735759

44.
Journal:	J Med Chem. 2005 Mar 10;48(5):1359-66.
Title:	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
Author:	Kubo, Kazuo\|Shimizu, Toshiyuki\|Ohyama, Shin-ichi\|Murooka, Hideko\|Iwai, Akemi\|Nakamura, Kazuhide\|Hasegawa, Kazumasa\|Kobayashi, Yoshiko\|Takahashi, Noriko\|Takahashi, Kazumi\|Kato, Shinichiro\|Izawa, Toshio\|Isoe, Toshiyuki
PMID:	15743179

45.
Journal:	J Med Chem. 2005 Mar 10;48(5):1610-9.
Title:	Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.
Author:	Harris, Philip A\|Cheung, Mui\|Hunter, Robert N 3rd\|Brown, Matthew L\|Veal, James M\|Nolte, Robert T\|Wang, Liping\|Liu, Wendy\|Crosby, Renae M\|Johnson, Jennifer H\|Epperly, Andrea H\|Kumar, Rakesh\|Luttrell, Deirdre K\|Stafford, Jeffrey A
PMID:	15743202

46.
Journal:	Cancer Res. 2005 May 1;65(9):3716-25.
Title:	Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model.
Author:	Yokoi, Kenji\|Thaker, Premal H\|Yazici, Sertac\|Rebhun, Robert R\|Nam, Do-Hyun\|He, Junqin\|Kim, Sun-Jin\|Abbruzzese, James L\|Hamilton, Stanley R\|Fidler, Isaiah J
PMID:	15867367

47.
Journal:	Curr Cancer Drug Targets. 2005 May;5(3):171-93.
Title:	Molecularly targeted therapy for gastrointestinal cancer.
Author:	Wiedmann, Marcus W\|Caca, Karel
PMID:	15892618

48.
Journal:	Di Yi Jun Yi Da Xue Xue Bao. 2005 May;25(5):524-7.
Title:	[Adenovirus-mediated CDglyTK fusion gene system driven by KDR promoter selectively kills colorectal cancer cells].
Author:	Lin, Rong-kai\|Huang, Zong-hai\|Su, Guo-qiang\|Ke, Zhi-yong\|Chen, Jian-xiong\|Zhou, Jin-jie
PMID:	15897124

49.
Journal:	J Surg Res. 2005 Sep;128(1):140-6.
Title:	Silibinin inhibits angiogenesis via Flt-1, but not KDR, receptor up-regulation.
Author:	Yang, Shung-Haur\|Lin, Jen-Kou\|Huang, Chi-Jung\|Chen, Wei-Shone\|Li, Shih-Yun\|Chiu, Jen-Hwey
PMID:	15993897

50.
Journal:	Oncology. 2005;68(2-3):204-11. Epub 2005 Jul 7.
Title:	Autocrine vascular endothelial growth factor/vascular endothelial growth factor receptor-2 growth pathway represents a cyclooxygenase-2-independent target for the cyclooxygenase-2 inhibitor NS-398 in colon cancer cells.
Author:	Kim, Seok Jin\|Seo, Jae Hong\|Lee, Yoo Jung\|Yoon, Ji Hye\|Choi, Chul Won\|Kim, Byung Soo\|Shin, Sang Won\|Kim, Yeul Hong\|Kim, Jun Suk
PMID:	16015035

51.
Journal:	Zhonghua Wei Chang Wai Ke Za Zhi. 2005 Mar;8(2):147-50.
Title:	[Adenovirus mediated double suicide gene under controlling by KDR promoter selectively kills vascular endothelial cells and colorectal tumor cells].
Author:	Huang, Zong-hai\|Su, Guo-qiang\|Yang, Zu-li\|Yu, Jin-long\|Li, Zhou\|Fan, Ying-fang\|Song, Hui-juan
PMID:	16155828

52.
Journal:	Cancer Res. 2005 Oct 15;65(20):9253-60.
Title:	Detection of early antiangiogenic effects in human colon adenocarcinoma xenografts: in vivo changes of tumor blood volume in response to experimental VEGFR tyrosine kinase inhibitor.
Author:	Kim, Young Ro\|Yudina, Anna\|Figueiredo, Joseluis\|Reichardt, Wilfried\|Hu-Lowe, Dana\|Petrovsky, Alexander\|Kang, Hye Won\|Torres, Denise\|Mahmood, Umar\|Weissleder, Ralph\|Bogdanov, Alexei A Jr
PMID:	16230386

53.
Journal:	Bull Cancer. 2005 Aug;92(Spec no):S29-36.
Title:	[Therapeutic strategies using VEGF inhibitors in colorectal cancer].
Author:	Boige, Valerie\|Malka, David\|Ducreux, Michel
PMID:	16387667

54.
Journal:	Int J Cancer. 2006 Feb 1;118(3):755-64.
Title:	Monitoring multiple angiogenesis-related molecules in the blood of cancer patients shows a correlation between VEGF-A and MMP-9 levels before treatment and divergent changes after surgical vs. conservative therapy.
Author:	Zaman, Khalil\|Driscoll, Robert\|Hahn, Diane\|Werffeli, Patricia\|Goodman, Simon L\|Bauer, Jean\|Leyvraz, Serge\|Lejeune, Ferdy\|Stupp, Roger\|Ruegg, Curzio
PMID:	16114015

55.
Journal:	Virchows Arch. 2006 Feb;448(2):127-34. Epub 2005 Sep 22.
Title:	Endoglin (CD105) expression in angiogenesis of colon cancer: analysis using tissue microarrays and comparison with other endothelial markers.
Author:	Minhajat, Rahmawati\|Mori, Daisuke\|Yamasaki, Fumio\|Sugita, Yasuo\|Satoh, Toshimi\|Tokunaga, Osamu
PMID:	16177881

56.
Journal:	Eur J Cancer. 2006 Jan;42(1):112-7.
Title:	Vascular endothelial growth factors and receptors in colorectal cancer: implications for anti-angiogenic therapy.
Author:	Duff, Sarah E\|Jeziorska, Maria\|Rosa, Daniela D\|Kumar, Shant\|Haboubi, Najib\|Sherlock, David\|O'Dwyer, Sarah T\|Jayson, Gordon C
PMID:	16321517

57.
Journal:	Arch Surg. 2006 Apr;141(4):367-74; discussion 374.
Title:	Short interfering RNA-mediated gene silencing of vascular endothelial growth factor: effects on cellular proliferation in colon cancer cells.
Author:	Mulkeen, Abby L\|Silva, Teresa\|Yoo, Peter S\|Schmitz, John C\|Uchio, Edward\|Chu, Edward\|Cha, Charles
PMID:	16618894

58.
Journal:	J Cell Physiol. 2006 Aug;208(2):344-53.
Title:	Anti-tumor activity of the combination of cetuximab, an anti-EGFR blocking monoclonal antibody and ZD6474, an inhibitor of VEGFR and EGFR tyrosine kinases.
Author:	Morelli, Maria Pia\|Cascone, Tina\|Troiani, Teresa\|Tuccillo, Concetta\|Bianco, Roberto\|Normanno, Nicola\|Romano, Marco\|Veneziani, Bianca Maria\|Fontanini, Gabriella\|Eckhardt, S Gail\|De Pacido, Sabino\|Tortora, Giampaolo\|Ciardiello, Fortunato
PMID:	16688779

59.
Journal:	J Med Chem. 2006 Jun 29;49(13):3766-9.
Title:	Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2.
Author:	Borzilleri, Robert M\|Bhide, Rajeev S\|Barrish, Joel C\|D'Arienzo, Celia J\|Derbin, George M\|Fargnoli, Joseph\|Hunt, John T\|Jeyaseelan, Robert Sr\|Kamath, Amrita\|Kukral, Daniel W\|Marathe, Punit\|Mortillo, Steve\|Qian, Ligang\|Tokarski, John S\|Wautlet, Barri S\|Zhen
PMID:	16789733

60.
Journal:	Mol Cancer Ther. 2006 Jul;5(7):1744-53.
Title:	The effects of the oral, pan-VEGF-R kinase inhibitor CEP-7055 and chemotherapy in orthotopic models of glioblastoma and colon carcinoma in mice.
Author:	Jones-Bolin, Susan\|Zhao, Hugh\|Hunter, Kathryn\|Klein-Szanto, Andres\|Ruggeri, Bruce
PMID:	16891460

61.
Journal:	Mol Cancer Ther. 2006 Jul;5(7):1883-94.
Title:	Sequence-dependent inhibition of human colon cancer cell growth and of prosurvival pathways by oxaliplatin in combination with ZD6474 (Zactima), an inhibitor of VEGFR and EGFR tyrosine kinases.
Author:	Troiani, Teresa\|Lockerbie, Owen\|Morrow, Mark\|Ciardiello, Fortunato\|Eckhardt, S Gail
PMID:	16891475

62.
Journal:	Mol Cancer Ther. 2006 Aug;5(8):2070-7.
Title:	Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts.
Author:	Nguyen, Quang-De\|Rodrigues, Sylvie\|Rodrigue, Christelle M\|Rivat, Christine\|Grijelmo, Clara\|Bruyneel, Erik\|Emami, Shahin\|Attoub, Samir\|Gespach, Christian
PMID:	16928828

63.
Journal:	World J Gastroenterol. 2006 Aug 28;12(32):5140-7.
Title:	Prolonged exposure of colon cancer cells to the epidermal growth factor receptor inhibitor gefitinib (Iressa(TM)) and to the antiangiogenic agent ZD6474: Cytotoxic and biomolecular effects.
Author:	Azzariti, Amalia\|Porcelli, Letizia\|Xu, Jian-Ming\|Simone, Grazia Maria\|Paradiso, Angelo
PMID:	16937523

64.
Journal:	Pathol Int. 2006 Dec;56(12):717-23.
Title:	Organ-specific endoglin (CD105) expression in the angiogenesis of human cancers.
Author:	Minhajat, Rahmawati\|Mori, Daisuke\|Yamasaki, Fumio\|Sugita, Yasuo\|Satoh, Toshimi\|Tokunaga, Osamu
PMID:	17096728

65.
Journal:	Nucl Med Biol. 2006 Nov;33(8):963-9.
Title:	Radioiodinated VEGF to image tumor angiogenesis in a LS180 tumor xenograft model.
Author:	Yoshimoto, Mitsuyoshi\|Kinuya, Seigo\|Kawashima, Atsuhiro\|Nishii, Ryuichi\|Yokoyama, Kunihiko\|Kawai, Keiichi
PMID:	17127168

66.
Journal:	Oncogene. 2007 Mar 29;26(14):2133-5. Epub 2006 Oct 2.
Title:	Absence of tyrosine kinase mutations in Japanese colorectal cancer patients.
Author:	Shao, R-X\|Kato, N\|Lin, L-J\|Muroyama, R\|Moriyama, M\|Ikenoue, T\|Watabe, H\|Otsuka, M\|Guleng, B\|Ohta, M\|Tanaka, Y\|Kondo, S\|Dharel, N\|Chang, J-H\|Yoshida, H\|Kawabe, T\|Omata, M
PMID:	17016444

67.
Journal:	Gene Ther. 2007 Mar;14(6):503-13. Epub 2006 Dec 14.
Title:	Inhibition of angiogenesis by a Semliki Forest virus vector expressing VEGFR-2 reduces tumour growth and metastasis in mice.
Author:	Lyons, J A\|Sheahan, B J\|Galbraith, S E\|Mehra, R\|Atkins, G J\|Fleeton, M N
PMID:	17167497

68.
Journal:	J Clin Oncol. 2007 Mar 1;25(7):884-96.
Title:	Sunitinib: from rational design to clinical efficacy.
Author:	Chow, Laura Q M\|Eckhardt, S Gail
PMID:	17327610

69.
Journal:	Nan Fang Yi Ke Da Xue Xue Bao. 2007 May;27(5):624-7.
Title:	[Targeted killing of colorectal tumor cells by lentiviral constructs containing CD/TK suicide genes and KDR promoter].
Author:	Chen, Hai-jin\|Huang, Zong-hai\|Wu, Ai-guo\|Yu, Jin-long\|Su, Guo-qiang
PMID:	17545072

70.
Journal:	Cancer Res. 2007 Jul 15;67(14):6899-906.
Title:	Discovery and validation of biomarkers that respond to treatment with brivanib alaninate, a small-molecule VEGFR-2/FGFR-1 antagonist.
Author:	Ayers, Mark\|Fargnoli, Joseph\|Lewin, Anne\|Wu, Qiuyan\|Platero, J Suso
PMID:	17638901

71.
Journal:	J Gastrointest Surg. 2007 Nov;11(11):1521-8.
Title:	Underexpression of mineralocorticoid receptor in colorectal carcinomas and association with VEGFR-2 overexpression.
Author:	Di Fabio, Francesco\|Alvarado, Carlos\|Majdan, Agnieszka\|Gologan, Adrian\|Voda, Linda\|Mitmaker, Elliot\|Beitel, Lenore K\|Gordon, Philip H\|Trifiro, Mark
PMID:	17703341

72.
Journal:	Eur J Clin Invest. 2007 Nov;37(11):878-86. Epub 2007 Sep 20.
Title:	Activated VEGFR2/KDR pathway in tumour cells and tumour associated vessels of colorectal cancer.
Author:	Giatromanolaki, A\|Koukourakis, M I\|Sivridis, E\|Chlouverakis, G\|Vourvouhaki, E\|Turley, H\|Harris, A L\|Gatter, K C
PMID:	17883421

73.
Journal:	Eur J Cancer. 2007 Nov;43(17):2612-20.
Title:	A novel angiogenesis inhibitor, Ki23057, is useful for preventing the progression of colon cancer and the spreading of cancer cells to the liver.
Author:	Sakurai, Katsunobu\|Yamada, Nobuya\|Yashiro, Masakazu\|Matsuzaki, Taro\|Komatsu, Midori\|Ohira, Masaichi\|Miwa, Atsushi\|Hirakawa, Kosei
PMID:	17949968

74.
Journal:	World J Gastroenterol. 2007 Nov 28;13(44):5857-66.
Title:	New approaches in angiogenic targeting for colorectal cancer.
Author:	Prat, Aleix\|Casado, Esther\|Cortes, Javier
PMID:	17990351

75.
Journal:	Neoplasia. 2007 Dec;9(12):1066-77.
Title:	Inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation on tumor-associated endothelial cells leads to treatment of orthotopic human colon cancer in nude mice.
Author:	Sasaki, Takamitsu\|Kitadai, Yasuhiko\|Nakamura, Toru\|Kim, Jang-Seong\|Tsan, Rachel Z\|Kuwai, Toshio\|Langley, Robert R\|Fan, Dominic\|Kim, Sun-Jin\|Fidler, Isaiah J
PMID:	18084614

76.
Journal:	Pharmacogenomics. 2007 Dec;8(12):1705-13.
Title:	Serum lactate dehydrogenase levels and glycolysis significantly correlate with tumor VEGFA and VEGFR expression in metastatic CRC patients.
Author:	Azuma, Mizutomo\|Shi, Michael\|Danenberg, Kathleen D\|Gardner, Humphrey\|Barrett, Carl\|Jacques, Christian J\|Sherod, Andrew\|Iqbal, Syma\|El-Khoueiry, Anthony\|Yang, Dongyun\|Zhang, Wu\|Danenberg, Peter V\|Lenz, Heinz-Josef
PMID:	18086000

77.
Journal:	Cancer Res. 2008 Jan 1;68(1):285-91.
Title:	Differential involvement of vascular endothelial growth factor in the survival of hypoxic colon cancer cells.
Author:	Calvani, Maura\|Trisciuoglio, Daniela\|Bergamaschi, Cristina\|Shoemaker, Robert H\|Melillo, Giovanni
PMID:	18172321

78.
Journal:	Zhonghua Wei Chang Wai Ke Za Zhi. 2008 Jan;11(1):61-6.
Title:	[Specific killing effects of combination of recombinant adenovirus containing double suicide gene driven by KDR promoter and survivin antisense oligonucleotide on colorectal cancer cells and vascular endothelial cells].
Author:	Yao, Hang\|Huang, Zong-hai\|Li, Zhou\|Su, Guo-qiang\|He, Rong\|Gao, Feng\|Cui, Da-xiang
PMID:	18197498

79.
Journal:	Crit Rev Oncol Hematol. 2008 Apr;66(1):21-30.
Title:	Potential predictive markers of response to EGFR-targeted therapies in colorectal cancer.
Author:	Spano, Jean Philippe\|Milano, Gerard\|Vignot, Stephane\|Khayat, David
PMID:	18206383

80.
Journal:	Ann Surg Oncol. 2008 Apr;15(4):1232-8.
Title:	Messenger RNA expression of vascular endothelial growth factor and its receptors in primary colorectal cancer and corresponding liver metastasis.
Author:	Kobayashi, Hirotoshi\|Sugihara, Kenichi\|Uetake, Hiroyuki\|Higuchi, Tetsuro\|Yasuno, Masamichi\|Enomoto, Masayuki\|Kuramochi, Hidekazu\|Lenz, Heinz-Josef\|Danenberg, Kathleen D\|Danenberg, Peter V
PMID:	18239970

81.
Journal:	Int J Oncol. 2008 Mar;32(3):585-92.
Title:	Hypoxia-induced epithelial VEGF-C/VEGFR-3 upregulation in carcinoma cell lines.
Author:	Simiantonaki, Nektaria\|Jayasinghe, Caren\|Michel-Schmidt, Romi\|Peters, Kirsten\|Hermanns, Maria Iris\|Kirkpatrick, Charles James
PMID:	18292935

82.
Journal:	Clin Exp Metastasis. 2008;25(4):477-89.
Title:	Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy.
Author:	Kuwai, Toshio\|Nakamura, Toru\|Sasaki, Takamitsu\|Kitadai, Yasuhiko\|Kim, Jang-Seong\|Langley, Robert R\|Fan, Dominic\|Wang, Xuemei\|Do, Kim-Anh\|Kim, Sun-Jin\|Fidler, Isaiah J
PMID:	18324358

83.
Journal:	J Med Chem. 2008 Mar 27;51(6):1668-80.
Title:	Evaluation of a series of naphthamides as potent, orally active vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors.
Author:	Weiss, Matthew M\|Harmange, Jean-Christophe\|Polverino, Anthony J\|Bauer, David\|Berry, Loren\|Berry, Virginia\|Borg, George\|Bready, James\|Chen, Danlin\|Choquette, Deborah\|Coxon, Angela\|DeMelfi, Tom\|Doerr, Nicholas\|Estrada, Juan\|Flynn, Julie\|Graceffa, Russell F\|
PMID:	18324759

84.
Journal:	Mol Cancer Ther. 2008 Mar;7(3):590-8.
Title:	Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice.
Author:	Alferez, Denis\|Wilkinson, Robert W\|Watkins, Jim\|Poulsom, Richard\|Mandir, Nikki\|Wedge, Stephen R\|Pyrah, Ian T\|Smith, Neil R\|Jackson, Lynsay\|Ryan, Anderson J\|Goodlad, Robert A
PMID:	18347145

85.
Journal:	Cancer Biother Radiopharm. 2008 Apr;23(2):222-8.
Title:	The effect of emodin on VEGF receptors in human colon cancer cells.
Author:	Lu, Yingying\|Zhang, Jianliang\|Qian, Jiaming
PMID:	18454691

86.
Journal:	J Surg Res. 2008 Aug;148(2):158-63.
Title:	Hepatic ischemia-reperfusion increases vascular endothelial growth factor and cancer growth in rats.
Author:	Tamagawa, Koji\|Horiuchi, Tetsuya\|Uchinami, Masaru\|Doi, Koji\|Yoshida, Makoto\|Nakamura, Tomoaki\|Sasaki, Hisashi\|Taniguchi, Masanobu\|Tanaka, Kuniyoshi
PMID:	18468635

87.
Journal:	Hum Pathol. 2008 Oct;39(10):1483-94.
Title:	Up-regulation of the hypoxia-inducible factor-1 transcriptional pathway in colorectal carcinomas.
Author:	Furlan, Daniela\|Sahnane, Nora\|Carnevali, Ileana\|Cerutti, Roberta\|Bertoni, Francesco\|Kwee, Ivo\|Uccella, Silvia\|Bertolini, Valentina\|Chiaravalli, Anna Maria\|Capella, Carlo
PMID:	18619649

88.
Journal:	BMC Res Notes. 2008 Aug 28;1:71.
Title:	Quantification of circulating endothelial and progenitor cells: comparison of quantitative PCR and four-channel flow cytometry.
Author:	Steurer, Michael\|Kern, Johann\|Zitt, Matthias\|Amberger, Albert\|Bauer, Monika\|Gastl, Gunther\|Untergasser, Gerold\|Gunsilius, Eberhard
PMID:	18755033

89.
Journal:	Mol Cancer Ther. 2008 Sep;7(9):3064-70.
Title:	Effect of chemotherapeutic stress on induction of vascular endothelial growth factor family members and receptors in human colorectal cancer cells.
Author:	Fan, Fan\|Gray, Michael J\|Dallas, Nikolaos A\|Yang, Anthony D\|Van Buren, George 2nd\|Camp, E Ramsay\|Ellis, Lee M
PMID:	18790786

90.
Journal:	Cancer Sci. 2008 Oct;99(10):2083-96.
Title:	Antitumor activities of synthetic and natural stilbenes through antiangiogenic action.
Author:	Kimura, Yoshiyuki\|Sumiyoshi, Maho\|Baba, Kimiye
PMID:	19016770

91.
Journal:	Cancer Lett. 2009 Jan 8;273(1):28-34.
Title:	Isolation and characterization of human anti-VEGF165 monoclonal antibody with anti-tumor efficacy from transgenic mice expressing human immunoglobulin loci.
Author:	Liu, Yu\|Yun, Dong-jie\|Chen, Jian-quan\|Zhao, Jian-yang\|Liu, Si-guo\|Cheng, Guo-xiang
PMID:	18774636

92.
Journal:	Oncol Rep. 2009 Apr;21(4):933-9.
Title:	Comparative study of human colonic tumor-derived endothelial cells (HCTEC) and normal colonic microvascular endothelial cells (HCMEC): Hypoxia-induced sVEGFR-1 and sVEGFR-2 levels.
Author:	Jayasinghe, Caren\|Simiantonaki, Nektaria\|Michel-Schmidt, Romi\|Kirkpatrick, Charles James
PMID:	19287991

93.
Journal:	Cancer Chemother Pharmacol. 2009 Nov;64(6):1165-72.
Title:	Phase I, dose escalation and pharmacokinetic study of cediranib (RECENTIN), a highly potent and selective VEGFR signaling inhibitor, in Japanese patients with advanced solid tumors.
Author:	Yamamoto, Noboru\|Tamura, Tomohide\|Yamamoto, Nobuyuki\|Yamada, Kazuhiko\|Yamada, Yasuhide\|Nokihara, Hiroshi\|Fujiwara, Yutaka\|Takahashi, Toshiaki\|Murakami, Haruyasu\|Boku, Narikazu\|Yamazaki, Kentaro\|Puchalski, Thomas A\|Shin, Eisei
PMID:	19308410

94.
Journal:	Oncol Rep. 2009 May;21(5):1161-8.
Title:	No functional and transductional significance of specific neuropilin 1 siRNA inhibition in colon carcinoma cell lines lacking VEGF receptor 2.
Author:	Quante, Michael\|Raskopf, Esther\|Stahl, Sebastian\|Vogt, Annabelle\|Sauerbruch, Tilman\|Schmitz, Volker
PMID:	19360289

95.
Journal:	Cancer Chemother Pharmacol. 2009 Dec;65(1):55-66.
Title:	Preclinical pharmacokinetics and in vitro metabolism of brivanib (BMS-540215), a potent VEGFR2 inhibitor and its alanine ester prodrug brivanib alaninate.
Author:	Marathe, Punit H\|Kamath, Amrita V\|Zhang, Yueping\|D'Arienzo, Celia\|Bhide, Rajeev\|Fargnoli, Joseph
PMID:	19396600

96.
Journal:	Anticancer Res. 2009 Mar;29(3):881-8.
Title:	The contribution of vascular endothelial growth factor to the induction of regulatory T-cells in malignant effusions.
Author:	Wada, Junji\|Suzuki, Hiroyuki\|Fuchino, Ryouta\|Yamasaki, Akio\|Nagai, Shuntaro\|Yanai, Kousuke\|Koga, Kenichiro\|Nakamura, Masafumi\|Tanaka, Masao\|Morisaki, Takashi\|Katano, Mitsuo
PMID:	19414323

97.
Journal:	Curr Opin Investig Drugs. 2009 Jun;10(6):597-605.
Title:	Ramucirumab, a fully human mAb to the transmembrane signaling tyrosine kinase VEGFR-2 for the potential treatment of cancer.
Author:	Krupitskaya, Yelena\|Wakelee, Heather A
PMID:	19513949

98.
Journal:	Anticancer Res. 2009 Jun;29(6):1987-92.
Title:	Impact of tumor cell VEGF expression on the in vivo efficacy of vandetanib (ZACTIMA; ZD6474).
Author:	Siemann, Dietmar W\|Norris, Christina M\|Ryan, Anderson\|Shi, Wenyin
PMID:	19528456

99.
Journal:	Anticancer Res. 2009 Jun;29(6):1999-2007.
Title:	Prioritization of EGFR/IGF-IR/VEGFR2 combination targeted therapies utilizing cancer models.
Author:	Tonra, James R\|Corcoran, Erik\|Deevi, Dhanvanthri S\|Steiner, Philipp\|Kearney, Jessica\|Li, Huiling\|Ludwig, Dale L\|Zhu, Zhenping\|Witte, Larry\|Surguladze, David\|Hicklin, Daniel J
PMID:	19528458

100.
Journal:	Jpn J Clin Oncol. 2009 Sep;39(9):543-51.
Title:	Anti-angiogenic therapy against gastrointestinal tract cancers.
Author:	Iwasaki, Junko\|Nihira, Shin-ichi
PMID:	19531544

101.
Journal:	Epigenetics. 2009 Jul 1;4(5):313-21. Epub 2009 Jul 3.
Title:	The expression of VEGF receptor genes is concurrently influenced by epigenetic gene silencing of the genes and VEGF activation.
Author:	Kim, Jee Yeon\|Hwang, Jun Ha\|Zhou, Wei\|Shin, Jieun\|Noh, Seung Moo\|Song, In Sang\|Kim, Ji Yeon\|Lee, Suk Hoon\|Kim, Jei
PMID:	19633424

102.
Journal:	Rev Med Liege. 2009 May-Jun;64(5-6):274-8.
Title:	[Monoclonal antibodies therapies for colorectal cancer: cetuximab, panitumumab and bevacizumab].
Author:	Piront, P\|Van Daele, D\|Belaiche, J\|Polus, M
PMID:	19642458

103.
Journal:	Br J Cancer. 2009 Oct 6;101(7):1183-93.
Title:	VEGF(121)b, a new member of the VEGF(xxx)b family of VEGF-A splice isoforms, inhibits neovascularisation and tumour growth in vivo.
Author:	Rennel, E S\|Varey, A H R\|Churchill, A J\|Wheatley, E R\|Stewart, L\|Mather, S\|Bates, D O\|Harper, S J
PMID:	19707198

104.
Journal:	Nat Rev Clin Oncol. 2009 Oct;6(10):569-79.
Title:	An overview of small-molecule inhibitors of VEGFR signaling.
Author:	Ivy, S Percy\|Wick, Jeannette Y\|Kaufman, Bennett M
PMID:	19736552

105.
Journal:	BioDrugs. 2009;23(5):289-304.
Title:	Monoclonal antibodies targeting vascular endothelial growth factor: current status and future challenges in cancer therapy.
Author:	Hsu, Jerry Y\|Wakelee, Heather A
PMID:	19754219

106.
Journal:	J Nucl Med. 2009 Nov;50(11):1857-64.
Title:	Using dual-tracer PET to predict the biologic behavior of human colorectal cancer.
Author:	Wang, Hui\|Zhang, Jinming\|Tian, Jiahe\|Qu, Baolin\|Li, Tianran\|Chen, Yingmao\|Liu, Jian\|Wang, Shan
PMID:	19837754

107.
Journal:	Target Oncol. 2009 Dec;4(4):297-305.
Title:	Axitinib--a selective inhibitor of the vascular endothelial growth factor (VEGF) receptor.
Author:	Kelly, Ronan J\|Rixe, Olivier
PMID:	19876699

108.
Journal:	J Angiogenes Res. 2009 Sep 21;1:5.
Title:	DCE-MRI assessment of the effect of vandetanib on tumor vasculature in patients with advanced colorectal cancer and liver metastases: a randomized phase I study.
Author:	Mross, Klaus\|Fasol, Ulrike\|Frost, Annette\|Benkelmann, Robin\|Kuhlmann, Jan\|Buchert, Martin\|Unger, Clemens\|Blum, Hubert\|Hennig, Jurgen\|Milenkova, Tsveta P\|Tessier, Jean\|Krebs, Annetta D\|Ryan, Anderson J\|Fischer, Richard
PMID:	19946413

109.
Journal:	Curr Opin Mol Ther. 2009 Dec;11(6):611-22.
Title:	Predictive biomarkers of clinical response to targeted antibodies in colorectal cancer.
Author:	Chua, Wei\|Moore, Melissa M\|Charles, Kellie A\|Clarke, Stephen J
PMID:	20072938

110.
Journal:	Mol Med Rep. 2009 Sep-Oct;2(5):787-92.
Title:	Quantitative analysis of vascular endothelial growth factor receptors 1 and 2 in colorectal cancer.
Author:	Hansen, Torben F\|Garm Spindler, Karen-Lise\|Lorentzen, Karen A\|Olsen, Dorte A\|Andersen, Rikke F\|Lindebjerg, Jan\|Brandslund, Ivan\|Jakobsen, Anders
PMID:	21475902

111.
Journal:	Epigenetics. 2009 Jul 1;4(5):313-321.
Title:	The expression of VEGF receptor genes is concurrently influenced by epigenetic gene silencing of the genes and VEGF activation.
Author:	Kim, Jee Yeon\|Whang, Jun Ha\|Zhou, Wei\|Shin, Jieun\|Noh, Seung Moo\|Song, In Sang\|Kim, Ji Yeon\|Lee, Suk Hoon\|Kim, Jei
PMID:	28001118

112.
Journal:	Invest New Drugs. 2010 Jun;28(3):350-2.
Title:	Acute left ventricular dysfunction induced by a panHER and VEGFR tyrosine kinase inhibitor in a phase I trial.
Author:	Bahleda, Rastislav\|Massard, Christophe\|Soria, Jean-Charles\|Izzedine, Hassan\|Cohen, Ariel\|Ederhy, Stephane
PMID:	19396400

113.
Journal:	Dig Liver Dis. 2010 Jan;42(1):20-7.
Title:	Heterogeneous expression of cyclooxygenase-2 and inducible nitric oxide synthase within colorectal tumors: correlation with tumor angiogenesis.
Author:	Cianchi, F\|Cuzzocrea, S\|Vinci, M C\|Messerini, L\|Comin, C E\|Navarra, G\|Perigli, G\|Centorrino, T\|Marzocco, S\|Lenzi, E\|Battisti, N\|Trallori, G\|Masini, E
PMID:	19497798

114.
Journal:	Surg Endosc. 2010 Feb;24(2):283-9.
Title:	Minimally invasive colon resection for malignant colonic conditions is associated with a transient early increase in plasma sVEGFR1 and a decrease in sVEGFR2 levels after surgery.
Author:	Shantha Kumara, H M C\|Cabot, J C\|Hoffman, A\|Luchtefeld, M\|Kalady, M F\|Hyman, N\|Feingold, D\|Baxter, R\|Whelan, R L
PMID:	19551437

115.
Journal:	Int J Colorectal Dis. 2010 Feb;25(2):181-6.
Title:	K-ras mutation status correlates with the expression of VEGFR1, VEGFR2, and PDGFRalpha in colorectal cancer.
Author:	Schimanski, Carl C\|Zimmermann, Tim\|Schmidtmann, Irene\|Gockel, Ines\|Lang, Hauke\|Galle, Peter R\|Moehler, Markus\|Berger, Martin R
PMID:	19936766

116.
Journal:	Virchows Arch. 2010 Mar;456(3):251-60.
Title:	Microvessel density and the association with single nucleotide polymorphisms of the vascular endothelial growth factor receptor 2 in patients with colorectal cancer.
Author:	Hansen, Torben Frostrup\|Sorensen, Flemming Brandt\|Spindler, Karen-Lise Garm\|Olsen, Dorte Aalund\|Andersen, Rikke Fredslund\|Lindebjerg, Jan\|Brandslund, Ivan\|Jakobsen, Anders
PMID:	20143086

117.
Journal:	MAbs. 2010 Mar-Apr;2(2):199-208.
Title:	Anti-tumor effect of CT-322 as an adnectin inhibitor of vascular endothelial growth factor receptor-2.
Author:	Mamluk, Roni\|Carvajal, Irvith M\|Morse, Brent A\|Wong, Henry\|Abramowitz, Janette\|Aslanian, Sharon\|Lim, Ai-Ching\|Gokemeijer, Jochem\|Storek, Michael J\|Lee, Joonsoo\|Gosselin, Michael\|Wright, Martin C\|Camphausen, Ray T\|Wang, Jack\|Chen, Yan\|Miller, Kathy\|Sanders
PMID:	20190562

118.
Journal:	BMC Cancer. 2010 Mar 11;10:93.
Title:	Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer.
Author:	Eppenberger, Manuela\|Zlobec, Inti\|Baumhoer, Daniel\|Terracciano, Luigi\|Lugli, Alessandro
PMID:	20222950

119.
Journal:	Chem Biol Interact. 2010 May 14;185(3):247-52.
Title:	(-)-Epigallocatechin gallate inhibits growth and activation of the VEGF/VEGFR axis in human colorectal cancer cells.
Author:	Shimizu, Masahito\|Shirakami, Yohei\|Sakai, Hiroyasu\|Yasuda, Yoichi\|Kubota, Masaya\|Adachi, Seiji\|Tsurumi, Hisashi\|Hara, Yukihiko\|Moriwaki, Hisataka
PMID:	20346928

120.
Journal:	Radiology. 2010 Aug;256(2):519-27.
Title:	Antiangiogenic cancer therapy: monitoring with molecular US and a clinically translatable contrast agent (BR55).
Author:	Pysz, Marybeth A\|Foygel, Kira\|Rosenberg, Jarrett\|Gambhir, Sanjiv S\|Schneider, Michel\|Willmann, Jurgen K
PMID:	20515975

121.
Journal:	Biochem Biophys Res Commun. 2010 Jul 23;398(2):205-11.
Title:	Sunitinib deregulates tumor adaptation to hypoxia by inhibiting HIF-1alpha synthesis in HT-29 colon cancer cells.
Author:	Shin, Hyun-Woo\|Cho, Chung-Hyun\|Kim, Tae-You\|Park, Jong-Wan
PMID:	20599738

122.
Journal:	Clin Cancer Res. 2010 Jul 15;16(14):3548-61.
Title:	Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers.
Author:	Smith, Neil R\|Baker, Dawn\|James, Neil H\|Ratcliffe, Kirsty\|Jenkins, Martin\|Ashton, Susan E\|Sproat, Graham\|Swann, Ruth\|Gray, Neil\|Ryan, Anderson\|Jurgensmeier, Juliane M\|Womack, Chris
PMID:	20606037

123.
Journal:	Biochem Pharmacol. 2010 Oct 15;80(8):1152-9.
Title:	Antiangiogenic effect of licochalcone A.
Author:	Kim, Yoon Hee\|Shin, Eun Kyung\|Kim, Dae Hwan\|Lee, Hee Hwan\|Park, Jung Han Yoon\|Kim, Jin-Kyung
PMID:	20637733

124.
Journal:	IDrugs. 2010 Sep;13(9):636-45.
Title:	Tivozanib, a pan-VEGFR tyrosine kinase inhibitor for the potential treatment of solid tumors.
Author:	De Luca, Antonella\|Normanno, Nicola
PMID:	20799147

125.
Journal:	J Biol Chem. 2010 Dec 10;285(50):39211-23.
Title:	Butyrate-rich colonic microenvironment is a relevant selection factor for metabolically adapted tumor cells.
Author:	Serpa, Jacinta\|Caiado, Francisco\|Carvalho, Tania\|Torre, Cheila\|Goncalves, Luis G\|Casalou, Cristina\|Lamosa, Pedro\|Rodrigues, Margarida\|Zhu, Zhenping\|Lam, Eric W F\|Dias, Sergio
PMID:	20926374

126.
Journal:	Cancer Res. 2010 Nov 1;70(21):8357-67.
Title:	Differential effects of VEGFR-1 and VEGFR-2 inhibition on tumor metastases based on host organ environment.
Author:	Lee, Yoon-Jin\|Karl, Daniel L\|Maduekwe, Ugwuji N\|Rothrock, Courtney\|Ryeom, Sandra\|D'Amore, Patricia A\|Yoon, Sam S
PMID:	20978198

127.
Journal:	J Med Chem. 2010 Nov 25;53(22):8140-9.
Title:	Novel potent orally active multitargeted receptor tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of 2-indolinone derivatives.
Author:	Cho, Tang Peng\|Dong, Su Yi\|Jun, Feng\|Hong, Fu Jian\|Liang, Yang Jiang\|Lu, Xiao\|Hua, Peng Jiang\|Li, Li Ya\|Lei, Zhang\|Bing, Hu\|Ying, Zhou\|Qiong, Li Fang\|Bei, Fu Bei\|Guang, Lou Li\|Shen, Gong Ai\|Hong, She Gao\|Hong, Sun Wei\|Tai, Mong Xian
PMID:	21028894

128.
Journal:	Anticancer Res. 2010 Oct;30(10):4209-17.
Title:	Molecular predictors of combination targeted therapies (cetuximab, bevacizumab) in irinotecan-refractory colorectal cancer (BOND-2 study).
Author:	Zhang, Wu\|Azuma, Mizutomo\|Lurje, Georg\|Gordon, Michael A\|Yang, Dongyun\|Pohl, Alexandra\|Ning, Yan\|Bohanes, Pierre\|Gerger, Armin\|Winder, Thomas\|Hollywood, Ellen\|Danenberg, Kathleen D\|Saltz, Leonard\|Lenz, Heinz-Josef
PMID:	21036743

129.
Journal:	J Exp Med. 2010 Dec 20;207(13):2855-68.
Title:	VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer.
Author:	Waldner, Maximilian J\|Wirtz, Stefan\|Jefremow, Andre\|Warntjen, Moritz\|Neufert, Clemens\|Atreya, Raja\|Becker, Christoph\|Weigmann, Benno\|Vieth, Michael\|Rose-John, Stefan\|Neurath, Markus F
PMID:	21098094

130.
Journal:	BMC Cancer. 2010 Dec 15;10:683.
Title:	VEGFR2 heterogeneity and response to anti-angiogenic low dose metronomic cyclophosphamide treatment.
Author:	Patten, Steven G\|Adamcic, Una\|Lacombe, Kristen\|Minhas, Kanwal\|Skowronski, Karolina\|Coomber, Brenda L
PMID:	21159176

131.
Journal:	Oncol Lett. 2010 Mar;1(2):253-259.
Title:	Association of plasma VEGF-A, soluble VEGFR-1 and VEGFR-2 levels and clinical response and survival in advanced colorectal cancer patients receiving bevacizumab with modified FOLFOX6.
Author:	Aoyagi, Yoshiko\|Iinuma, Hisae\|Horiuchi, Atsushi\|Shimada, Ryu\|Watanabe, Toshiaki
PMID:	22966290

132.
Journal:	Mol Imaging Biol. 2011 Dec;13(6):1173-82.
Title:	In vivo, dual-modality OCT/LIF imaging using a novel VEGF receptor-targeted NIR fluorescent probe in the AOM-treated mouse model.
Author:	Winkler, Amy M\|Rice, Photini F S\|Weichsel, Jan\|Watson, Jennifer M\|Backer, Marina V\|Backer, Joseph M\|Barton, Jennifer K
PMID:	21042865

133.
Journal:	Clin Cancer Res. 2011 Feb 15;17(4):849-60.
Title:	Phase I safety, pharmacokinetic, and pharmacodynamic study of ENMD-2076, a novel angiogenic and Aurora kinase inhibitor, in patients with advanced solid tumors.
Author:	Diamond, Jennifer R\|Bastos, Bruno R\|Hansen, Ryan J\|Gustafson, Daniel L\|Eckhardt, S Gail\|Kwak, Eunice L\|Pandya, Shuchi S\|Fletcher, Graham C\|Pitts, Todd M\|Kulikowski, Gillian N\|Morrow, Mark\|Arnott, Jamie\|Bray, Mark R\|Sidor, Carolyn\|Messersmith, Wells\|Shapir
PMID:	21131552

134.
Journal:	Mol Cancer Res. 2011 Feb;9(2):195-202.
Title:	GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway.
Author:	Pathi, Satya S\|Jutooru, Indira\|Chadalapaka, Gayathri\|Sreevalsan, Sandeep\|Anand, S\|Thatcher, Gregory Rj\|Safe, Stephen
PMID:	21156786

135.
Journal:	Br J Cancer. 2011 Apr 12;104(8):1270-7.
Title:	Chronic exposure of colorectal cancer cells to bevacizumab promotes compensatory pathways that mediate tumour cell migration.
Author:	Fan, F\|Samuel, S\|Gaur, P\|Lu, J\|Dallas, N A\|Xia, L\|Bose, D\|Ramachandran, V\|Ellis, L M
PMID:	21407219

136.
Journal:	J Biol Chem. 2011 Jun 3;286(22):19641-51.
Title:	The biflavonoid amentoflavone inhibits neovascularization preventing the activity of proangiogenic vascular endothelial growth factors.
Author:	Tarallo, Valeria\|Lepore, Laura\|Marcellini, Marcella\|Dal Piaz, Fabrizio\|Tudisco, Laura\|Ponticelli, Salvatore\|Lund, Frederik Wendelboe\|Roepstorff, Peter\|Orlandi, Augusto\|Pisano, Claudio\|De Tommasi, Nunziatina\|De Falco, Sandro
PMID:	21471210

137.
Journal:	Anticancer Res. 2011 Mar;31(3):843-7.
Title:	Co-localization of prothrombin fragment F1+2 and VEGF-R2-bound VEGF in human colon cancer.
Author:	Sierko, Ewa\|Wojtukiewicz, Marek Z\|Zimnoch, Lech\|Thorpe, Philip E\|Brekken, Rolf A\|Kisiel, Walter
PMID:	21498704

138.
Journal:	Hepatogastroenterology. 2011 Jan-Feb;58(105):122-6.
Title:	Pringle maneuver induces hepatic metastasis by stimulating the tumor vasculature.
Author:	Ozawa, Shutaro\|Akimoto, Naoe\|Tawara, Hideyuki\|Yamada, Masami\|Sato, Takahiro\|Tashiro, Jo\|Hosonuma, Tomonori\|Ishii, Toshimasa\|Yamaguchi, Shigeki\|Husejima, Yusuhe\|Hanawa, Mineo\|Koyama, Isamu
PMID:	21510298

139.
Journal:	Mol Nutr Food Res. 2011 Jun;55(6):832-43.
Title:	Cancer chemoprevention with green tea catechins by targeting receptor tyrosine kinases.
Author:	Shimizu, Masahito\|Adachi, Seiji\|Masuda, Muneyuki\|Kozawa, Osamu\|Moriwaki, Hisataka
PMID:	21538846

140.
Journal:	Clin Cancer Res. 2011 May 15;17(10):3469-77.
Title:	Biomarkers for cetuximab-based neoadjuvant radiochemotherapy in locally advanced rectal cancer.
Author:	Grimminger, Peter P\|Danenberg, Peter\|Dellas, Kathrin\|Arnold, Dirk\|Rodel, Claus\|Machiels, Jean-Pascal\|Haustermans, Karin\|Debucquoy, Annelies\|Velenik, Vaneja\|Sempoux, Christine\|Bracko, Matej\|Holscher, Arnulf H\|Semrau, Robert\|Yang, Dongyun\|Danenberg, Kathlee
PMID:	21558395

141.
Journal:	Int J Cancer. 2011 Nov 1;129(9):2115-23.
Title:	Inhibition of VEGF induces cellular senescence in colorectal cancer cells.
Author:	Hasan, Mohammad R\|Ho, Shirley H Y\|Owen, David A\|Tai, Isabella T
PMID:	21618508

142.
Journal:	Cell Physiol Biochem. 2011;27(5):565-74.
Title:	SKLB610: a novel potential inhibitor of vascular endothelial growth factor receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo.
Author:	Cao, Zhi-Xing\|Zheng, Ren-Lin\|Lin, Hong-Jun\|Luo, Shi-Dong\|Zhou, Yan\|Xu, You-Zhi\|Zeng, Xiu-Xiu\|Wang, Zhao\|Zhou, Li-Na\|Mao, Yong-Qiu\|Yang, Li\|Wei, Yu-Quan\|Yu, Luo-Ting\|Yang, Sheng-Yong\|Zhao, Ying-Lan
PMID:	21691074

143.
Journal:	Cancer. 2011 Dec 15;117(24):5601-11.
Title:	Colorectal carcinoma cell production of transforming growth factor beta decreases expression of endothelial cell vascular endothelial growth factor receptor 2.
Author:	Kuczynski, Elizabeth A\|Viloria-Petit, Alicia M\|Coomber, Brenda L
PMID:	21692070

144.
Journal:	Vasc Cell. 2011 Jul 29;3:16.
Title:	Phase I study of telatinib (BAY 57-9352): analysis of safety, pharmacokinetics, tumor efficacy, and biomarkers in patients with colorectal cancer.
Author:	Mross, Klaus\|Frost, Annette\|Scheulen, Max E\|Krauss, Jurgen\|Strumberg, Dirk\|Schultheiss, Beate\|Fasol, Ulrike\|Buchert, Martin\|Kratzschmer, Jorn\|Delesen, Heinz\|Rajagopalan, Prabhu\|Christensen, Olaf
PMID:	21801343

145.
Journal:	Anticancer Res. 2011 Sep;31(9):2971-4.
Title:	The efficacy of gemcitabine as salvage treatment in patients with refractory advanced colorectal cancer (CRC): a single institution experience.
Author:	Saif, Muhammad Wasif\|Kaley, Kristin\|Penney, Robin\|Hotchkiss, Susan\|Syrigos, Kostas N\|Strimpakos, Alexios S
PMID:	21868546

146.
Journal:	Nutr Cancer. 2011;63(7):1133-42.
Title:	Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.
Author:	Pathi, Satya S\|Lei, Ping\|Sreevalsan, Sandeep\|Chadalapaka, Gayathri\|Jutooru, Indira\|Safe, Stephen
PMID:	21919647

147.
Journal:	Nutr J. 2011 Sep 26;10:99.
Title:	Bioactive properties and clinical safety of a novel milk protein peptide.
Author:	Kreider, Richard B\|Iosia, Mike\|Cooke, Matt\|Hudson, Geoffrey\|Rasmussen, Chris\|Chen, Helen\|Mollstedt, Olof\|Tsai, Men-Hwei
PMID:	21943352

148.
Journal:	Z Gastroenterol. 2011 Oct;49(10):1398-406.
Title:	Biomarkers of anti-angiogenic therapy in metastatic colorectal cancer (mCRC): original data and review of the literature.
Author:	Pohl, M\|Werner, N\|Munding, J\|Tannapfel, A\|Graeven, U\|Nickenig, G\|Schmiegel, W\|Reinacher-Schick, A
PMID:	21964893

149.
Journal:	Clin Cancer Res. 2011 Nov 15;17(22):7156-63.
Title:	Biologic and clinical activity of tivozanib (AV-951, KRN-951), a selective inhibitor of VEGF receptor-1, -2, and -3 tyrosine kinases, in a 4-week-on, 2-week-off schedule in patients with advanced solid tumors.
Author:	Eskens, Ferry A L M\|de Jonge, Maja J A\|Bhargava, Pankaj\|Isoe, Toshiyuki\|Cotreau, Monette M\|Esteves, Brooke\|Hayashi, Kunihiko\|Burger, Herman\|Thomeer, Maarten\|van Doorn, Leni\|Verweij, Jaap
PMID:	21976547

150.
Journal:	PLoS One. 2011;6(12):e28841.
Title:	Antitumor activity of sorafenib in human cancer cell lines with acquired resistance to EGFR and VEGFR tyrosine kinase inhibitors.
Author:	Morgillo, Floriana\|Martinelli, Erika\|Troiani, Teresa\|Orditura, Michele\|De Vita, Ferdinando\|Ciardiello, Fortunato
PMID:	22174910

151.
Journal:	Oncology. 2011;81 Suppl 1:18-23.
Title:	Signaling pathways in hepatocellular carcinoma.
Author:	Sia, Daniela\|Villanueva, Augusto
PMID:	22212931

152.
Journal:	Oncol Lett. 2011 Nov;2(6):1101-1106.
Title:	Elevated microRNA-126 is associated with high vascular endothelial growth factor receptor 2 expression levels and high microvessel density in colorectal cancer.
Author:	Hansen, Torben Frostrup\|Andersen, Claus Lindbjerg\|Nielsen, Boye Schnack\|Spindler, Karen-Lise Garm\|Sorensen, Flemming Brandt\|Lindebjerg, Jan\|Brandslund, Ivan\|Jakobsen, Anders
PMID:	22848274

153.
Journal:	Br J Pharmacol. 2012 Feb;165(4b):1084-96.
Title:	Plumbagin inhibits tumour angiogenesis and tumour growth through the Ras signalling pathway following activation of the VEGF receptor-2.
Author:	Lai, Li\|Liu, Junchen\|Zhai, Dong\|Lin, Qingxiang\|He, Lijun\|Dong, Yanmin\|Zhang, Jing\|Lu, Binbin\|Chen, Yihua\|Yi, Zhengfang\|Liu, Mingyao
PMID:	21658027

154.
Journal:	Clin Cancer Res. 2012 Jan 15;18(2):454-64.
Title:	Targeting tumor-associated endothelial cells: anti-VEGFR2 immunoliposomes mediate tumor vessel disruption and inhibit tumor growth.
Author:	Wicki, Andreas\|Rochlitz, Christoph\|Orleth, Annette\|Ritschard, Reto\|Albrecht, Imke\|Herrmann, Richard\|Christofori, Gerhard\|Mamot, Christoph
PMID:	22065082

155.
Journal:	Ann Surg. 2012 Jan;255(1):86-94.
Title:	Angiogenesis in synchronous and metachronous colorectal liver metastases: the liver as a permissive soil.
Author:	van der Wal, Gesiena E\|Gouw, Annette S H\|Kamps, Jan A A M\|Moorlag, Henk E\|Bulthuis, Marian L C\|Molema, Grietje\|de Jong, Koert P
PMID:	22156924

156.
Journal:	Clin Cancer Res. 2012 Feb 1;18(3):688-99.
Title:	Primary colorectal cancers and their subsequent hepatic metastases are genetically different: implications for selection of patients for targeted treatment.
Author:	Vermaat, Joost S\|Nijman, Isaac J\|Koudijs, Marco J\|Gerritse, Frank L\|Scherer, Stefan J\|Mokry, Michal\|Roessingh, Wijnand M\|Lansu, Nico\|de Bruijn, Ewart\|van Hillegersberg, Richard\|van Diest, Paul J\|Cuppen, Edwin\|Voest, Emile E
PMID:	22173549

157.
Journal:	Cancer Sci. 2012 Mar;103(3):561-8.
Title:	Potentially functional genetic variants in KDR gene as prognostic markers in patients with resected colorectal cancer.
Author:	Dong, Guanglong\|Guo, Xu\|Fu, Xiaoying\|Wan, Shaogui\|Zhou, Feng\|Myers, Ronald E\|Bao, Guoqiang\|Burkart, Ashlie\|Yang, Hushan\|Xing, Jinliang
PMID:	22182247

158.
Journal:	Cancer Sci. 2012 Apr;103(4):813-20.
Title:	Zinc finger E-box binding homeobox 1 promotes vasculogenic mimicry in colorectal cancer through induction of epithelial-to-mesenchymal transition.
Author:	Liu, Zhiyong\|Sun, Baocun\|Qi, Lisha\|Li, Hui\|Gao, Jun\|Leng, Xue
PMID:	22212097

159.
Journal:	Angiogenesis. 2012 Mar;15(1):141-50.
Title:	A phase II study of neoadjuvant bevacizumab plus capecitabine and concomitant radiotherapy in patients with locally advanced rectal cancer.
Author:	Gasparini, Giampietro\|Torino, Francesco\|Ueno, Takayuki\|Cascinu, Stefano\|Troiani, Teresa\|Ballestrero, Alberto\|Berardi, Rossana\|Shishido, Junichi\|Yoshizawa, Akihiko\|Mori, Yukiko\|Nagayama, Satoshi\|Morosini, Paola\|Toi, Masakazu
PMID:	22212406

160.
Journal:	BMC Cancer. 2012 Jan 25;12:37.
Title:	Biomarkers for antitumor activity of bevacizumab in gastric cancer models.
Author:	Yamashita-Kashima, Yoriko\|Fujimoto-Ouchi, Kaori\|Yorozu, Keigo\|Kurasawa, Mitsue\|Yanagisawa, Mieko\|Yasuno, Hideyuki\|Mori, Kazushige
PMID:	22273502

161.
Journal:	Mol Ther. 2012 May;20(5):938-47.
Title:	Soluble vascular endothelial growth factor decoy receptor FP3 exerts potent antiangiogenic effects.
Author:	Yu, De-Chao\|Lee, Jung-Sun\|Yoo, Ji Young\|Shin, Hyewon\|Deng, Hongxin\|Wei, Yuquan\|Yun, Chae-Ok
PMID:	22273580

162.
Journal:	World J Gastroenterol. 2012 Feb 21;18(7):637-45.
Title:	Identification of colorectal cancer metastasis markers by an angiogenesis-related cytokine-antibody array.
Author:	Abajo, Ana\|Bitarte, Nerea\|Zarate, Ruth\|Boni, Valentina\|Lopez, Ines\|Gonzalez-Huarriz, Marisol\|Rodriguez, Javier\|Bandres, Eva\|Garcia-Foncillas, Jesus
PMID:	22363134

163.
Journal:	Int Immunopharmacol. 2012 May;13(1):37-45.
Title:	Ad-KDRscFv:sTRAIL displays a synergistic antitumor effect without obvious cytotoxicity to normal tissues.
Author:	Yang, Liuqin\|Guo, Jun\|Wang, Jun\|Wan, Shunmei\|Yang, Shiming\|Wang, Rongquan\|Chen, Wensheng\|Peng, Guiyong\|Fang, Dianchun
PMID:	22406047

164.
Journal:	Int J Mol Med. 2012 Jul;30(1):126-32.
Title:	Antitumor effect of FP3 in combination with cetuximab on patient-derived tumor tissue xenograft models of primary colon carcinoma and related lymphatic and hepatic metastases.
Author:	Dong, Xiaofang\|Jin, Ketao\|Hu, Xiaoyan\|Du, Fangmin\|Lan, Huanrong\|Han, Na\|Ma, Zhaosheng\|Xie, Bojian\|Cui, Binbin\|Teng, Lisong\|Cao, Feilin
PMID:	22505231

165.
Journal:	Asian Pac J Cancer Prev. 2012;13(2):499-503.
Title:	Norcantharidin anti-angiogenesis activity possibly through an endothelial cell pathway in human colorectal cancer.
Author:	Yu, Tao\|Hou, Fenggang\|Liu, Manman\|Zhou, Lihong\|Li, Dan\|Liu, Jianrong\|Fan, Zhongze\|Li, Qi
PMID:	22524814

166.
Journal:	Cancer Biol Ther. 2012 Jul;13(9):737-44.
Title:	Antitumor effects of FP3 in combination with capecitabine on PDTT xenograft models of primary colon carcinoma and related lymphatic and hepatic metastases.
Author:	Jin, Ketao\|Lan, Huanrong\|Xie, Bojian\|He, Kuifeng\|Xu, Zhenzhen\|Li, Guangliang\|Han, Na\|Teng, Lisong\|Cao, Feilin
PMID:	22617773

167.
Journal:	Mol Med Rep. 2012 Aug;6(2):321-9.
Title:	Adenovirus-mediated tissue-targeted expression of the CDglyTk gene for the treatment of breast cancer.
Author:	Su, Guo-qiang\|Su, Gang\|Huang, Zong-hai
PMID:	22641384

168.
Journal:	PLoS One. 2012;7(6):e38231.
Title:	Phase I study of cetuximab, irinotecan, and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer.
Author:	Meyerhardt, Jeffrey A\|Ancukiewicz, Marek\|Abrams, Thomas A\|Schrag, Deborah\|Enzinger, Peter C\|Chan, Jennifer A\|Kulke, Matthew H\|Wolpin, Brian M\|Goldstein, Michael\|Blaszkowsky, Lawrence\|Zhu, Andrew X\|Elliott, Meaghan\|Regan, Eileen\|Jain, Rakesh K\|Duda, Dan G
PMID:	22701615

169.
Journal:	Tokai J Exp Clin Med. 2012 Jul 20;37(2):57-61.
Title:	Significant clinical response of advanced colon cancer to peptide vaccine therapy: a case report.
Author:	Yasuda, Seiei\|Tsuchiya, Izumi\|Okada, Kazutake\|Tanaka, Akira\|Suzuki, Toshiyuki\|Sadahiro, Sotaro\|Takeda, Kazuyoshi\|Yamamoto, Soichiro\|Nakui, Minoru
PMID:	22763829

170.
Journal:	Nan Fang Yi Ke Da Xue Xue Bao. 2012 Jun;32(7):1059-63.
Title:	[Granzyme B-VEGF receptor-binding peptide fusion protein expressed in B. longum induces apoptosis of KDR-positive cells].
Author:	Chen, Lei\|Zeng, Weisen\|Zheng, Hang
PMID:	22820600

171.
Journal:	Br J Cancer. 2012 Sep 25;107(7):1044-50.
Title:	Vascular density analysis in colorectal cancer patients treated with vatalanib (PTK787/ZK222584) in the randomised CONFIRM trials.
Author:	Giatromanolaki, A\|Koukourakis, M I\|Sivridis, E\|Gatter, K C\|Trarbach, T\|Folprecht, G\|Shi, M M\|Lebwohl, D\|Jalava, T\|Laurent, D\|Meinhardt, G\|Harris, A L
PMID:	22910317

172.
Journal:	Quant Imaging Med Surg. 2012 Jun;2(2):68-80.
Title:	Fast microbubble dwell-time based ultrasonic molecular imaging approach for quantification and monitoring of angiogenesis in cancer.
Author:	Pysz, Marybeth A\|Guracar, Ismayil\|Tian, Lu\|Willmann, Jurgen K
PMID:	22943043

173.
Journal:	BMC Complement Altern Med. 2012 Sep 19;12:160.
Title:	Astragalus saponins downregulate vascular endothelial growth factor under cobalt chloride-stimulated hypoxia in colon cancer cells.
Author:	Law, Pui-Ching\|Auyeung, Kathy K\|Chan, Lok-Yi\|Ko, Joshua K
PMID:	22992293

174.
Journal:	Cell Death Dis. 2012 Oct 11;3:e406.
Title:	A novel angiogenesis inhibitor impairs lovo cell survival via targeting against human VEGFR and its signaling pathway of phosphorylation.
Author:	Zhang, Y M\|Dai, B L\|Zheng, L\|Zhan, Y Z\|Zhang, J\|Smith, W W\|Wang, X L\|Chen, Y N\|He, L C
PMID:	23059825

175.
Journal:	BMC Cancer. 2012 Nov 12;12:514.
Title:	PDGFRalpha/beta and VEGFR2 polymorphisms in colorectal cancer: incidence and implications in clinical outcome.
Author:	Estevez-Garcia, Purificacion\|Castano, Angel\|Martin, Ana C\|Lopez-Rios, Fernando\|Iglesias, Joaquin\|Munoz-Galvan, Sandra\|Lopez-Calderero, Iker\|Molina-Pinelo, Sonia\|Pastor, Maria D\|Carnero, Amancio\|Paz-Ares, Luis\|Garcia-Carbonero, Rocio
PMID:	23146028

176.
Journal:	Nan Fang Yi Ke Da Xue Xue Bao. 2012 Nov;32(11):1658-62.
Title:	[Role of Ang-2, Tie-2 and VEGFR-2 in angiogenesis in colorectal carcinoma and their prognostic value].
Author:	Liu, Xinlan\|Li, Yigong\|Wei, Jianmin\|Zhao, Yanjiao
PMID:	23174599

177.
Journal:	Gan To Kagaku Ryoho. 2012 Nov;39(12):1760-2.
Title:	[Clinical study of Peptide-cocktail vaccination with tegafur-uracil/leucovorin for advanced colorectal cancer].
Author:	Sugiura, Fumiaki\|Inoue, Keisuke\|Okuno, Kiyotaka\|Sukegawa, Yasushi
PMID:	23267878

178.
Journal:	Invest New Drugs. 2013 Feb;31(1):1-13.
Title:	Circulating vascular endothelial growth factor receptor 2/pAkt-positive cells as a functional pharmacodynamic marker in metastatic colorectal cancers treated with antiangiogenic agent.
Author:	Shin, Sang Joon\|Hwang, Jee Won\|Ahn, Joong Bae\|Rha, Sun Young\|Roh, Jae Kyung\|Chung, Hyun Cheol
PMID:	22539090

179.
Journal:	Pharmacogenomics J. 2013 Oct;13(5):410-6.
Title:	Intratumoral expression profiling of genes involved in angiogenesis in colorectal cancer patients treated with chemotherapy plus the VEGFR inhibitor PTK787/ZK 222584 (vatalanib).
Author:	Wilson, P M\|Yang, D\|Azuma, M\|Shi, M M\|Danenberg, K D\|Lebwohl, D\|Sherrod, A\|Ladner, R D\|Zhang, W\|Danenberg, P V\|Trarbach, T\|Folprecht, G\|Meinhardt, G\|Lenz, H-J
PMID:	22664478

180.
Journal:	J Mol Med (Berl). 2013 Feb;91(2):271-82.
Title:	CAPE suppresses VEGFR-2 activation, and tumor neovascularization and growth.
Author:	Chung, Tae-Wook\|Kim, Seok-Jo\|Choi, Hee-Jung\|Kwak, Choong-Hwan\|Song, Kwon-Ho\|Suh, Seok-Jong\|Kim, Keuk-Jun\|Ha, Ki-Tae\|Park, Young-Guk\|Chang, Young-Chae\|Chang, Hyeun Wook\|Lee, Young-Choon\|Kim, Cheorl-Ho
PMID:	22935775

181.
Journal:	Cancer Res. 2013 Jan 15;73(2):539-49.
Title:	VEGFA-VEGFR pathway blockade inhibits tumor-induced regulatory T-cell proliferation in colorectal cancer.
Author:	Terme, Magali\|Pernot, Simon\|Marcheteau, Elie\|Sandoval, Federico\|Benhamouda, Nadine\|Colussi, Orianne\|Dubreuil, Olivier\|Carpentier, Antoine F\|Tartour, Eric\|Taieb, Julien
PMID:	23108136

182.
Journal:	Mol Carcinog. 2013 Nov;52 Suppl 1:E60-9.
Title:	Association of VEGF and KDR single nucleotide polymorphisms with colorectal cancer susceptibility in Koreans.
Author:	Jang, Moon Ju\|Jeon, Young Joo\|Kim, Jong Woo\|Cho, Yun Kyung\|Lee, Seung Ku\|Hwang, Seong Gyu\|Oh, Doyeun\|Kim, Nam Keun
PMID:	23169005

183.
Journal:	Clin Immunol. 2013 Jan;146(1):26-33.
Title:	Intratumoral FOXP3+VEGFR2+ regulatory T cells are predictive markers for recurrence and survival in patients with colorectal cancer.
Author:	Suzuki, Hiroyuki\|Onishi, Hideya\|Morisaki, Takashi\|Tanaka, Masao\|Katano, Mitsuo
PMID:	23202541

184.
Journal:	Oncol Rep. 2013 Mar;29(3):951-9.
Title:	Phase I clinical trial of a peptide vaccine combined with tegafur-uracil plus leucovorin for treatment of advanced or recurrent colorectal cancer.
Author:	Matsushita, Norimasa\|Aruga, Atsushi\|Inoue, Yuji\|Kotera, Yoshihito\|Takeda, Kazuyoshi\|Yamamoto, Masakazu
PMID:	23314271

185.
Journal:	Cancer Sci. 2013 May;104(5):604-10.
Title:	Norcantharidin inhibits tumor angiogenesis via blocking VEGFR2/MEK/ERK signaling pathways.
Author:	Zhang, Long\|Ji, Qing\|Liu, Xuan\|Chen, Xingzhu\|Chen, Zhaohua\|Qiu, Yanyan\|Sun, Jian\|Cai, Jianfeng\|Zhu, Huirong\|Li, Qi
PMID:	23363445

186.
Journal:	BioDrugs. 2013 Jun;27(3):213-24.
Title:	Regorafenib for gastrointestinal malignancies : from preclinical data to clinical results of a novel multi-target inhibitor.
Author:	Aprile, Giuseppe\|Macerelli, Marianna\|Giuliani, Francesco
PMID:	23435872

187.
Journal:	Cancer Treat Rev. 2013 Dec;39(8):908-24.
Title:	Molecular markers to predict outcome to antiangiogenic therapies in colorectal cancer: current evidence and future perspectives.
Author:	Custodio, Ana\|Barriuso, Jorge\|de Castro, Javier\|Martinez-Marin, Virginia\|Moreno, Victor\|Rodriguez-Salas, Nuria\|Feliu, Jaime
PMID:	23510598

188.
Journal:	PLoS One. 2013;8(3):e59410.
Title:	The decrease of mineralcorticoid receptor drives angiogenic pathways in colorectal cancer.
Author:	Tiberio, Laura\|Nascimbeni, Riccardo\|Villanacci, Vincenzo\|Casella, Claudio\|Fra, Anna\|Vezzoli, Valeria\|Furlan, Lucia\|Meyer, Giuliano\|Parrinello, Giovanni\|Baroni, Maurizio D\|Salerni, Bruno\|Schiaffonati, Luisa
PMID:	23555666

189.
Journal:	Med Oncol. 2013;30(2):572.
Title:	Gene expression profiling identifies EPHB4 as a potential predictive biomarker in colorectal cancer patients treated with bevacizumab.
Author:	Guijarro-Munoz, Irene\|Sanchez, Antonio\|Martinez-Martinez, Esther\|Garcia, Jose M\|Salas, Clara\|Provencio, Mariano\|Alvarez-Vallina, Luis\|Sanz, Laura
PMID:	23579861

190.
Journal:	Br J Pharmacol. 2013 Aug;169(8):1766-80.
Title:	YL529, a novel, orally available multikinase inhibitor, potently inhibits angiogenesis and tumour growth in preclinical models.
Author:	Xu, Youzhi\|Lin, Hongjun\|Meng, Nana\|Lu, Wenjie\|Li, Guobo\|Han, Yuanyuan\|Dai, Xiaoyun\|Xia, Yong\|Song, Xiangrong\|Yang, Shengyong\|Wei, Yuquan\|Yu, Luoting\|Zhao, Yinglan
PMID:	23594209

191.
Journal:	Cancer Genomics Proteomics. 2013 Mar-Apr;10(2):55-67.
Title:	Clinicopathological correlation and prognostic significance of VEGF-A, VEGF-C, VEGFR-2 and VEGFR-3 expression in colorectal cancer.
Author:	Martins, Sandra F\|Garcia, Eduardo A\|Luz, Marcus Alexandre Mendes\|Pardal, Fernando\|Rodrigues, Mesquita\|Filho, Adhemar Longatto
PMID:	23603341

192.
Journal:	Cancer Manag Res. 2013 Apr 12;5:49-55.
Title:	Critical appraisal of the use of regorafenib in the management of colorectal cancer.
Author:	Festino, Lucia\|Fabozzi, Alessio\|Manzo, Anna\|Gambardella, Valentina\|Martinelli, Erika\|Troiani, Teresa\|De Vita, Ferdinando\|Orditura, Michele\|Ciardiello, Fortunato\|Morgillo, Floriana
PMID:	23610528

193.
Journal:	Eur J Radiol. 2013 Sep;82(9):e484-91.
Title:	Evaluation of (1)(8)F-FDG and (1)(8)F-FLT for monitoring therapeutic responses of colorectal cancer cells to radiotherapy.
Author:	Wang, Hui\|Liu, Bo\|Tian, Jiahe\|Xu, Baixuan\|Zhang, Jinming\|Qu, Baolin\|Chen, Yingmao
PMID:	23639776

194.
Journal:	BMC Cancer. 2013 May 7;13:229.
Title:	Chronic inhibition of tumor cell-derived VEGF enhances the malignant phenotype of colorectal cancer cells.
Author:	Yamagishi, Naoko\|Teshima-Kondo, Shigetada\|Masuda, Kiyoshi\|Nishida, Kensei\|Kuwano, Yuki\|Dang, Duyen T\|Dang, Long H\|Nikawa, Takeshi\|Rokutan, Kazuhito
PMID:	23651517

195.
Journal:	Eur J Clin Invest. 2013 Aug;43(8):801-8.
Title:	Angiogenin outperforms VEGF, EPCs and CECs in predicting Dukes' and AJCC stage in colorectal cancer.
Author:	Ramcharan, Sean K\|Lip, Gregory Y H\|Stonelake, Paul S\|Blann, Andrew D
PMID:	23683169

196.
Journal:	J Surg Res. 2013 Nov;185(1):264-72.
Title:	Glucose-regulated protein 78 silencing down-regulates vascular endothelial growth factor/vascular endothelial growth factor receptor 2 pathway to suppress human colon cancer tumor growth.
Author:	Kuo, Li-Jen\|Hung, Chin-Sheng\|Chen, Wei-Yu\|Chang, Yu-Jia\|Wei, Po-Li
PMID:	23759331

197.
Journal:	J Biomed Sci. 2013 Jun 21;20:39.
Title:	Flt-1 in colorectal cancer cells is required for the tumor invasive effect of placental growth factor through a p38-MMP9 pathway.
Author:	Wei, Shu-Chen\|Tsao, Po-Nien\|Weng, Meng-Tzu\|Cao, Zhifang\|Wong, Jau-Min
PMID:	23799978

198.
Journal:	BMC Complement Altern Med. 2013 Jun 24;13:144.
Title:	Spica prunellae promotes cancer cell apoptosis, inhibits cell proliferation and tumor angiogenesis in a mouse model of colorectal cancer via suppression of stat3 pathway.
Author:	Lin, Wei\|Zheng, Liangpu\|Zhuang, Qunchuan\|Zhao, Jinyan\|Cao, Zhiyun\|Zeng, Jianwei\|Lin, Shan\|Xu, Wei\|Peng, Jun
PMID:	23800091

199.
Journal:	Eur J Nucl Med Mol Imaging. 2013 Oct;40(11):1635-44.
Title:	Clinical significance of VEGFR-2 and (1)(8)F-FDG PET/CT SUVmax pretreatment score in predicting the long-term outcome of patients with locally advanced rectal cancer treated with neoadjuvant therapy.
Author:	Sole, Claudio V\|Calvo, Felipe A\|Alvarez, Emilio\|Peligros, Isabel\|Garcia-Alfonso, Pilar\|Ferrer, Carlos\|Ochoa, Enrique\|Herranz, Rafael\|Carreras, Jose L
PMID:	23801169

200.
Journal:	Mol Cancer Ther. 2013 Sep;12(9):1749-62.
Title:	S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab.
Author:	Burbridge, Mike F\|Bossard, Celine J\|Saunier, Carine\|Fejes, Imre\|Bruno, Alain\|Leonce, Stephane\|Ferry, Gilles\|Da Violante, Georges\|Bouzom, Francois\|Cattan, Valerie\|Jacquet-Bescond, Anne\|Comoglio, Paolo M\|Lockhart, Brian P\|Boutin, Jean A\|Cordi, Alex\|Ortuno,
PMID:	23804704

201.
Journal:	Oncol Rep. 2013 Oct;30(4):1701-6.
Title:	Pien Tze Huang inhibits tumor angiogenesis in a mouse model of colorectal cancer via suppression of multiple cellular pathways.
Author:	Shen, Aling\|Lin, Jiumao\|Chen, Youqin\|Lin, Wei\|Liu, Liya\|Hong, Zhenfeng\|Sferra, Thomas J\|Peng, Jun
PMID:	23843018

202.
Journal:	Cancer Cell Int. 2013 Jul 12;13(1):69.
Title:	Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo.
Author:	Pan, Qin\|Pan, Hongming\|Lou, Haizhou\|Xu, Yinghua\|Tian, Lu
PMID:	23848964

203.
Journal:	BMC Complement Altern Med. 2013 Jul 24;13:189.
Title:	Particled Mica, STB-HO has chemopreventive potential via G1 arrest, and inhibition of proliferation and vascular endothelial growth factor receptor 2 in HCT colorectal cancer cells.
Author:	Cho, Sung-Yun\|Lee, Hyo-Jeong\|Cho, Sun-Mi\|Kim, Bonglee\|Jung, Yeon Kwon\|Kim, Sung-Hoon
PMID:	23883349

204.
Journal:	J Cell Mol Med. 2013 Oct;17(10):1316-24.
Title:	Brucine suppresses colon cancer cells growth via mediating KDR signalling pathway.
Author:	Luo, Wenjuan\|Wang, Xiaoli\|Zheng, Lei\|Zhan, Yingzhuan\|Zhang, Dongdong\|Zhang, Jie\|Zhang, Yanmin
PMID:	23905676

205.
Journal:	Oncoimmunology. 2013 Aug 1;2(8):e25156.
Title:	VEGFA/VEGFR2-targeted therapies prevent the VEGFA-induced proliferation of regulatory T cells in cancer.
Author:	Terme, Magali\|Tartour, Eric\|Taieb, Julien
PMID:	24083078

206.
Journal:	PLoS One. 2013 Nov 27;8(11):e81592.
Title:	Anti-cancer activity of an osthole derivative, NBM-T-BMX-OS01: targeting vascular endothelial growth factor receptor signaling and angiogenesis.
Author:	Yang, Hung-Yu\|Hsu, Ya-Fen\|Chiu, Pei-Ting\|Ho, Shiau-Jing\|Wang, Chi-Han\|Chi, Chih-Chin\|Huang, Yu-Han\|Lee, Cheng-Feng\|Li, Ying-Shiuan\|Ou, George\|Hsu, Ming-Jen
PMID:	24312323

207.
Journal:	Gan To Kagaku Ryoho. 2013 Nov;40(12):1584-6.
Title:	[Treatment outcome of peptide vaccination for advanced colorectal cancer].
Author:	Sugiura, Fumiaki\|Inoue, Keisuke\|Kogita, Akihiro\|Yoshioka, Yasumasa\|Hida, Jinichi\|Okuno, Kiyotaka\|Sukegawa, Yasushi
PMID:	24393856

208.
Journal:	Hepatogastroenterology. 2013 Nov-Dec;60(128):1950-4.
Title:	Antitumor effect of FP3 on a patient-derived tumor tissue xenograft model of rectal carcinoma.
Author:	Bi, Tienan\|Bi, Tienan\|Lan, Huanrong\|Hu, Xinxia\|Zhu, Min\|Xu, Zhenzhen\|Hu, Jinxi\|Teng, Lisong\|Jin, Ketao
PMID:	24719933

209.
Journal:	Clin Exp Med. 2014 May;14(2):203-13.
Title:	Synergic antitumor effect of SKLB1002 and local hyperthermia in 4T1 and CT26.
Author:	Nie, Wen\|Ma, Xue-lei\|Sang, Ya-xiong\|Li, Yu-li\|Gao, Xiang\|Xu, Guang-chao\|Shen, Guo-bo\|Shi, Hua-shan\|Liu, Xiao-xiao\|Wang, Feng-tian\|Wei, Yu-quan
PMID:	23263406

210.
Journal:	Mol Carcinog. 2014 Feb;53 Suppl 1:E140-50.
Title:	VEGFA, FLT1, KDR and colorectal cancer: assessment of disease risk, tumor molecular phenotype, and survival.
Author:	Slattery, Martha L\|Lundgreen, Abbie\|Wolff, Roger K
PMID:	23794399

211.
Journal:	Endocr Relat Cancer. 2013 Dec 20;21(1):73-84.
Title:	GDNF increases cell motility in human colon cancer through VEGF-VEGFR1 interaction.
Author:	Huang, Ssu-Ming\|Chen, Tzu-Sheng\|Chiu, Chien-Ming\|Chang, Leang-Kai\|Liao, Kuan-Fu\|Tan, Hsiao-Ming\|Yeh, Wei-Lan\|Chang, Gary Ro-Lin\|Wang, Min-Ying\|Lu, Dah-Yuu
PMID:	24165321

212.
Journal:	Int J Cancer. 2014 Sep 15;135(6):1487-96.
Title:	Regorafenib (BAY 73-4506): antitumor and antimetastatic activities in preclinical models of colorectal cancer.
Author:	Schmieder, Roberta\|Hoffmann, Jens\|Becker, Michael\|Bhargava, Ajay\|Muller, Tina\|Kahmann, Nicole\|Ellinghaus, Peter\|Adams, Robert\|Rosenthal, Andre\|Thierauch, Karl-Heinz\|Scholz, Arne\|Wilhelm, Scott M\|Zopf, Dieter
PMID:	24347491

213.
Journal:	J Surg Oncol. 2014 Feb;109(2):151-7.
Title:	Vascular progenitor clusters from peripheral blood in cancer patients following oncologic surgery.
Author:	Javidnia, Hedyeh\|Hanna, Mary\|Li, Yuhua\|Scheer, Adena\|Filion, Lionel\|Eapen, Libni\|Carrier, Marc\|Auer, Rebecca\|Corsten, Martin\|Allan, David S
PMID:	24449173

214.
Journal:	Cancer Lett. 2014 May 28;347(1):105-13.
Title:	Anti-tumor efficacy of ultrasonic cavitation is potentiated by concurrent delivery of anti-angiogenic drug in colon cancer.
Author:	Zhang, Chao\|Huang, Pintong\|Zhang, Ying\|Chen, Jian\|Shentu, Weihui\|Sun, Yu\|Yang, Zhijian\|Chen, Shuyuan
PMID:	24530229

215.
Journal:	J Control Release. 2014 Apr 28;180:1-9.
Title:	Photochemical internalization augments tumor vascular cytotoxicity and specificity of VEGF(121)/rGel fusion toxin.
Author:	Weyergang, Anette\|Cheung, Lawrence H\|Rosenblum, Michael G\|Mohamedali, Khalid A\|Peng, Qian\|Waltenberger, Johannes\|Berg, Kristian
PMID:	24531010

216.
Journal:	BMC Cancer. 2014 Feb 24;14:125.
Title:	Wnt3a expression is associated with MMP-9 expression in primary tumor and metastatic site in recurrent or stage IV colorectal cancer.
Author:	Lee, Myung Ah\|Park, Jin-Hee\|Rhyu, Si Young\|Oh, Seong-Taek\|Kang, Won-Kyoung\|Kim, Hee-Na
PMID:	24564183

217.
Journal:	Int J Mol Med. 2014 May;33(5):1261-7.
Title:	Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer.
Author:	Kim, Se-Lim\|Lee, Soo-Teik\|Trang, Kieu Thi Thu\|Kim, Seong Hun\|Kim, In Hee\|Lee, Seung Ok\|Kim, Dae Ghon\|Kim, Sang-Wook
PMID:	24573421

218.
Journal:	Nihon Rinsho. 2014 Jan;72(1):120-6.
Title:	[New molecular targeting drugs for metastatic colorectal cancer].
Author:	Komatsu, Yoshito\|Harada, Kazuaki\|Fukushima, Hiraku\|Yuki, Satoshi
PMID:	24597359

219.
Journal:	Cell Mol Immunol. 2014 May;11(3):285-93.
Title:	Potent anti-angiogenesis and anti-tumor activity of a novel human anti-VEGF antibody, MIL60.
Author:	Yang, Jing\|Wang, Qun\|Qiao, Chunxia\|Lin, Zhou\|Li, Xinying\|Huang, Yifei\|Zhou, Tingting\|Li, Yan\|Shen, Beifen\|Lv, Ming\|Feng, Jiannan
PMID:	24608894

220.
Journal:	J Transl Med. 2014 Mar 10;12:63.
Title:	A phase I study of combination vaccine treatment of five therapeutic epitope-peptides for metastatic colorectal cancer; safety, immunological response, and clinical outcome.
Author:	Hazama, Shoichi\|Nakamura, Yusuke\|Takenouchi, Hiroko\|Suzuki, Nobuaki\|Tsunedomi, Ryouichi\|Inoue, Yuka\|Tokuhisa, Yoshihiro\|Iizuka, Norio\|Yoshino, Shigefumi\|Takeda, Kazuyoshi\|Shinozaki, Hirokazu\|Kamiya, Akira\|Furukawa, Hiroyuki\|Oka, Masaaki
PMID:	24612787

221.
Journal:	BMC Cancer. 2014 Mar 13;14:178.
Title:	Vasculature analysis of patient derived tumor xenografts using species-specific PCR assays: evidence of tumor endothelial cells and atypical VEGFA-VEGFR1/2 signalings.
Author:	Bieche, Ivan\|Vacher, Sophie\|Vallerand, David\|Richon, Sophie\|Hatem, Rana\|De Plater, Ludmilla\|Dahmani, Ahmed\|Nemati, Fariba\|Angevin, Eric\|Marangoni, Elisabetta\|Roman-Roman, Sergio\|Decaudin, Didier\|Dangles-Marie, Virginie
PMID:	24625025

222.
Journal:	Oncologist. 2014 Apr;19(4):350-1.
Title:	An open-label phase II study evaluating the safety and efficacy of ramucirumab combined with mFOLFOX-6 as first-line therapy for metastatic colorectal cancer.
Author:	Garcia-Carbonero, Rocio\|Rivera, Fernando\|Maurel, Joan\|Ayoub, Jean-Pierre M\|Moore, Malcolm J\|Cervantes, Andres\|Asmis, Timothy R\|Schwartz, Jonathan D\|Nasroulah, Federico\|Ballal, Shaila\|Tabernero, Josep
PMID:	24674871

223.
Journal:	Arthritis Rheumatol. 2014 May;66(5):1300-5.
Title:	Brief report: impaired in vivo neovascularization capacity of endothelial progenitor cells in patients with systemic sclerosis.
Author:	Kuwana, Masataka\|Okazaki, Yuka
PMID:	24782187

224.
Journal:	Biochem Cell Biol. 2014 Jun;92(3):206-18.
Title:	Targeting angiogenic pathway for chemoprevention of experimental colon cancer using C-phycocyanin as cyclooxygenase-2 inhibitor.
Author:	Saini, Manpreet Kaur\|Sanyal, Sankar Nath
PMID:	24861078

225.
Journal:	Neoplasma. 2014;61(5):514-22.
Title:	SKLB-287, anovel oral multikinase inhibitor of EGFR and VEGFR2, exhibits potent antitumor activity in LoVo colorectal tumor model.
Author:	Chen, X\|Liu, Y\|Yang, H-W\|Zhou, S\|Cheng, C\|Zheng, M-W\|Zhong, L\|Fu, X-Y\|Pan, Y-L\|Ma, S\|Tang, Y\|Chen, Y-Z\|Li, L-L\|Yang, S-Y
PMID:	25030434

226.
Journal:	J Biomed Opt. 2014 Aug;19(8):086003.
Title:	Quantum dots targeted to vascular endothelial growth factor receptor 2 as a contrast agent for the detection of colorectal cancer.
Author:	Carbary-Ganz, Jordan L\|Barton, Jennifer K\|Utzinger, Urs
PMID:	25104409

227.
Journal:	Toxicol Appl Pharmacol. 2014 Dec 1;281(2):166-73.
Title:	Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways.
Author:	Tong, Qingyi\|Qing, Yong\|Wu, Yang\|Hu, Xiaojuan\|Jiang, Lei\|Wu, Xiaohua
PMID:	25111127

228.
Journal:	Br J Cancer. 2014 Oct 28;111(9):1742-9.
Title:	Effect of standard chemotherapy and antiangiogenic therapy on plasma markers and endothelial cells in colorectal cancer.
Author:	Ramcharan, K S\|Lip, G Y H\|Stonelake, P S\|Blann, A D
PMID:	25211664

229.
Journal:	Gan To Kagaku Ryoho. 2014 Oct;41(10):1276-9.
Title:	[Clinical trial of a seven-peptide vaccine and tegafur-uracil/leucovorin as combination therapy for advanced colorectal cancer].
Author:	Inoue, Keisuke\|Sugiura, Fumiaki\|Kogita, Akihiro\|Yoshioka, Yasumasa\|Sukegawa, Yasushi\|Hida, Jinichi\|Okuno, Kiyotaka
PMID:	25335716

230.
Journal:	Pol J Pathol. 2014 Oct;65(3):194-201.
Title:	Inverse correlation of phospho-KDR/Flk-1 expression and stage of colorectal cancer: implication of the significance of neoangiogenesis in activated VEGFR-2 expressing early stage colorectal adenocarcinomas.
Author:	Lin, Yi-Feng\|Chang, Chun-Chao\|Lin, Shu-Hui\|Yeh, Chung-Min\|Su, Tzu-Cheng\|Wu, Pei-Ru\|Yeh, Kun-Tu\|Jiang, Ming-Chung\|Chen, Pi-Yu\|Hsu, Hui-Ting
PMID:	25372416

231.
Journal:	Cancer Treat Rev. 2014 Dec;40(10):1171-81.
Title:	Navigating later lines of treatment for advanced colorectal cancer - optimizing targeted biological therapies to improve outcomes.
Author:	Gill, Sharlene\|Dowden, Scot\|Colwell, Bruce\|Collins, Loretta L\|Berry, Scott
PMID:	25458604

232.
Journal:	Cancers (Basel). 2014 Nov 26;6(4):2330-42.
Title:	Morpholino-Mediated Isoform Modulation of Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) Reduces Colon Cancer Xenograft Growth.
Author:	Stagg, Brian C\|Uehara, Hironori\|Lambert, Nathan\|Rai, Ruju\|Gupta, Isha\|Radmall, Bryce\|Bates, Taylor\|Ambati, Balamurali K
PMID:	25534570

233.
Journal:	Surg Today. 2015 Feb;45(2):215-20.
Title:	Soluble VEGFR1 concentration in the serum of patients with colorectal cancer.
Author:	Abbasi, Oranus\|Mashayekhi, Farhad\|Mirzajani, Ebrahim\|Fakhriyeh Asl, Saba\|Mahmoudi, Touraj\|Saeedi Saedi, Hamid
PMID:	24676933

234.
Journal:	Int J Cancer. 2015 Apr 15;136(8):1967-75.
Title:	Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model.
Author:	Song, Eun-Kee\|Tai, W M\|Messersmith, Wells A\|Bagby, Stacey\|Purkey, Alicia\|Quackenbush, Kevin S\|Pitts, Todd M\|Wang, Guoliang\|Blatchford, Patrick\|Yahn, Rachel\|Kaplan, Jeffrey\|Tan, Aik Choon\|Atreya, Chloe E\|Eckhardt, Gail\|Kelley, Robin K\|Venook, Alan\|Kwak, Eu
PMID:	25242168

235.
Journal:	Exp Mol Pathol. 2015 Jun;98(3):375-81.
Title:	Tissue-specific selection of optimal reference genes for expression analysis of anti-cancer drug-related genes in tumor samples using quantitative real-time RT-PCR.
Author:	Wang, Huijuan\|Yang, Bobo\|Geng, Tingting\|Li, Bin\|Dai, Penggao\|Chen, Chao
PMID:	25445497

236.
Journal:	Med Oncol. 2015 Jan;32(1):414.
Title:	Peroxiredoxin 2 is involved in vasculogenic mimicry formation by targeting VEGFR2 activation in colorectal cancer.
Author:	Zhang, Shouru\|Fu, Zhongxue\|Wei, Jinlai\|Guo, Jinbao\|Liu, Maoxi\|Du, Kunli
PMID:	25471788

237.
Journal:	Pharmacogenomics J. 2015 Aug;15(4):354-62.
Title:	Distinct gene expression profiles of proximal and distal colorectal cancer: implications for cytotoxic and targeted therapy.
Author:	Maus, M K H\|Hanna, D L\|Stephens, C L\|Astrow, S H\|Yang, D\|Grimminger, P P\|Loupakis, F\|Hsiang, J H\|Zeger, G\|Wakatsuki, T\|Barzi, A\|Lenz, H-J
PMID:	25532759

238.
Journal:	Invest Radiol. 2015 May;50(5):322-9.
Title:	Three-dimensional ultrasound molecular imaging of angiogenesis in colon cancer using a clinical matrix array ultrasound transducer.
Author:	Wang, Huaijun\|Kaneko, Osamu F\|Tian, Lu\|Hristov, Dimitre\|Willmann, Jurgen K
PMID:	25575176

239.
Journal:	Clin Cancer Res. 2015 Apr 1;21(7):1583-90.
Title:	Pharmacogenetic Analysis of INT 0144 Trial: Association of Polymorphisms with Survival and Toxicity in Rectal Cancer Patients Treated with 5-FU and Radiation.
Author:	Bohanes, Pierre\|Rankin, Cathryn J\|Blanke, Charles D\|Winder, Thomas\|Ulrich, Cornelia M\|Smalley, Stephen R\|Rich, Tyvin A\|Martensen, James A\|Benson, Al B 3rd\|Mayer, Robert J\|Cripps, Christine M\|Danenberg, Kathleen\|Makar, Karen W\|Zhang, Wu\|Benedetti, Jacqueli
PMID:	25589620

240.
Journal:	Int J Colorectal Dis. 2015 Mar;30(3):315-21.
Title:	Increased pre-surgical numbers of endothelial progenitor cells and circulating endothelial cells in colorectal cancer fail to predict outcome.
Author:	Ramcharan, K S\|Lip, G Y H\|Stonelake, P S\|Blann, A D
PMID:	25598043

241.
Journal:	Phytomedicine. 2015 Jan 15;22(1):103-10.
Title:	Raddeanin A, a triterpenoid saponin isolated from Anemone raddeana, suppresses the angiogenesis and growth of human colorectal tumor by inhibiting VEGFR2 signaling.
Author:	Guan, Ying-Yun\|Liu, Hai-Jun\|Luan, Xin\|Xu, Jian-Rong\|Lu, Qin\|Liu, Ya-Rong\|Gao, Yun-Ge\|Zhao, Mei\|Chen, Hong-Zhuan\|Fang, Chao
PMID:	25636878

242.
Journal:	Evid Based Complement Alternat Med. 2015;2015:454279.
Title:	Pien Tze Huang Inhibits Hypoxia-Induced Angiogenesis via HIF-1 alpha /VEGF-A Pathway in Colorectal Cancer.
Author:	Chen, Hongwei\|Feng, Jianyu\|Zhang, Yuchen\|Shen, Aling\|Chen, Youqin\|Lin, Jiumao\|Lin, Wei\|Sferra, Thomas J\|Peng, Jun
PMID:	25649293

243.
Journal:	Invest New Drugs. 2015 Jun;33(3):541-54.
Title:	Combretastatin A-4 derived imidazoles show cytotoxic, antivascular, and antimetastatic effects based on cytoskeletal reorganisation.
Author:	Mahal, Katharina\|Biersack, Bernhard\|Caysa, Henrike\|Schobert, Rainer\|Mueller, Thomas
PMID:	25678082

244.
Journal:	Int J Clin Exp Pathol. 2015 Jan 1;8(1):615-21. eCollection 2015.
Title:	Anticancer effect of salidroside on colon cancer through inhibiting JAK2/STAT3 signaling pathway.
Author:	Sun, Kuan-Xue\|Xia, Hong-Wei\|Xia, Rong-Long
PMID:	25755753

245.
Journal:	Org Biomol Chem. 2015 Apr 14;13(14):4296-309.
Title:	3-(Benzo[d][1,3]dioxol-5-ylamino)-N-(4-fluorophenyl)thiophene-2-carboxamide overcomes cancer chemoresistance via inhibition of angiogenesis and P-glycoprotein efflux pump activity.
Author:	Mudududdla, Ramesh\|Guru, Santosh K\|Wani, Abubakar\|Sharma, Sadhana\|Joshi, Prashant\|Vishwakarma, Ram A\|Kumar, Ajay\|Bhushan, Shashi\|Bharate, Sandip B
PMID:	25758415

246.
Journal:	Chem Biol Interact. 2015 May 5;232:58-67.
Title:	A therapeutically relevant, 3,3'-diindolylmethane derivative NGD16 attenuates angiogenesis by targeting glucose regulated protein, 78kDa (GRP78).
Author:	Nayak, Debasis\|Amin, Hina\|Rah, Bilal\|Ur Rasool, Reyaz\|Sharma, Deepak\|Gupta, Ajai Prakash\|Kushwaha, Manoj\|Mukherjee, Debaraj\|Goswami, Anindya
PMID:	25794856

247.
Journal:	Gastroenterology. 2015 Jul;149(1):177-189.e10.
Title:	VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice With Colitis.
Author:	Foersch, Sebastian\|Sperka, Tobias\|Lindner, Christina\|Taut, Astrid\|Rudolph, Karl L\|Breier, Georg\|Boxberger, Frank\|Rau, Tilman T\|Hartmann, Arndt\|Sturzl, Michael\|Wittkopf, Nadine\|Haep, Lisa\|Wirtz, Stefan\|Neurath, Markus F\|Waldner, Maximilian J
PMID:	25797700

248.
Journal:	Toxicol Appl Pharmacol. 2015 Jul 15;286(2):112-23.
Title:	Dopamine induces growth inhibition and vascular normalization through reprogramming M2-polarized macrophages in rat C6 glioma.
Author:	Qin, Tian\|Wang, Chenlong\|Chen, Xuewei\|Duan, Chenfan\|Zhang, Xiaoyan\|Zhang, Jing\|Chai, Hongyan\|Tang, Tian\|Chen, Honglei\|Yue, Jiang\|Li, Ying\|Yang, Jing
PMID:	25818600

249.
Journal:	Drug Des Devel Ther. 2015 Mar 18;9:1679-89.
Title:	Human colon carcinogenesis is associated with increased interleukin-17-driven inflammatory responses.
Author:	Xie, Zhaohui\|Qu, Yine\|Leng, Yanli\|Sun, Wenxiu\|Ma, Siqi\|Wei, Jingbo\|Hu, Jiangong\|Zhang, Xiaolan
PMID:	25834404

250.
Journal:	Clin Colorectal Cancer. 2015 Sep;14(3):154-61.
Title:	A Phase II Study of Sorafenib Combined With Cetuximab in EGFR-Expressing, KRAS-Mutated Metastatic Colorectal Cancer.
Author:	Do, Khanh\|Cao, Liang\|Kang, Zhigang\|Turkbey, Baris\|Lindenberg, Maria L\|Larkins, Erin\|Holkova, Beata\|Steinberg, Seth M\|Raffeld, Mark\|Peer, Cody J\|Figg, William D\|Eugeni, Michelle\|Jacobs, Paula\|Choyke, Peter\|Wright, John J\|Doroshow, James H\|Kummar, Shivaani
PMID:	25861837

251.
Journal:	J Transl Med. 2015 Feb 12;13:57.
Title:	Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib.
Author:	Wong, Andrea Li Ann\|Lim, Joline Si Jing\|Sinha, Arvind\|Gopinathan, Anil\|Lim, Robert\|Tan, Chee-Seng\|Soh, Thomas\|Venkatesh, Sudhakar\|Titin, Christina\|Sapari, Nur Sabrina\|Lee, Soo-Chin\|Yong, Wei-Peng\|Tan, David Shao Ping\|Pang, Brendan\|Wang, Ting-Ting\|Zee, Yin
PMID:	25889309

252.
Journal:	Onco Targets Ther. 2015 Apr 15;8:835-43.
Title:	The significance of combining VEGFA, FLT1, and KDR expressions in colon cancer patient prognosis and predicting response to bevacizumab.
Author:	Zhang, Shu-Dong\|McCrudden, Cian M\|Meng, Chen\|Lin, Yao\|Kwok, Hang Fai
PMID:	25926745

253.
Journal:	J Exp Clin Cancer Res. 2015 May 13;34:42.
Title:	The relevance of cell type- and tumor zone-specific VEGFR-2 activation in locally advanced colon cancer.
Author:	Jayasinghe, Caren\|Simiantonaki, Nektaria\|Habedank, Sylvia\|Kirkpatrick, Charles James
PMID:	25967108

254.
Journal:	Ultrasound Med Biol. 2015 Aug;41(8):2202-11.
Title:	VEGFR2-Targeted Contrast-Enhanced Ultrasound to Distinguish between Two Anti-Angiogenic Treatments.
Author:	Payen, Thomas\|Dizeux, Alexandre\|Baldini, Capucine\|Le Guillou-Buffello, Delphine\|Lamuraglia, Michele\|Comperat, Eva\|Lucidarme, Olivier\|Bridal, S Lori
PMID:	25980323

255.
Journal:	J Natl Cancer Inst. 2015 Jun 13;107(9). pii: djv160.
Title:	A Candidate-Pathway Approach to Identify Gene-Environment Interactions: Analyses of Colon Cancer Risk and Survival.
Author:	Sharafeldin, Noha\|Slattery, Martha L\|Liu, Qi\|Franco-Villalobos, Conrado\|Caan, Bette J\|Potter, John D\|Yasui, Yutaka
PMID:	26072521

256.
Journal:	Sci Rep. 2015 Jun 18;5:11275.
Title:	Mannan-modified adenovirus targeting TERT and VEGFR-2: A universal tumour vaccine.
Author:	Wang, Ying\|Zhang, Jie\|Wu, Yang\|Ding, Zhen-Yu\|Luo, Xin-Mei\|Liu, Jie\|Zhong, Wu-Ning\|Deng, Guo-Hua\|Xia, Xiang-Yu\|Deng, Yao-Tiao\|Wei, Yu-Quan\|Jiang, Yu
PMID:	26085010

257.
Journal:	Front Oncol. 2015 Jun 3;5:125.
Title:	Neuropilin-1 as Therapeutic Target for Malignant Melanoma.
Author:	Graziani, Grazia\|Lacal, Pedro M
PMID:	26090340

258.
Journal:	PLoS One. 2015 Jun 24;10(6):e0131363.
Title:	Simultaneous inhibition of EGFR/VEGFR and cyclooxygenase-2 targets stemness-related pathways in colorectal cancer cells.
Author:	Valverde, Araceli\|Penarando, Jon\|Canas, Amanda\|Lopez-Sanchez, Laura M\|Conde, Francisco\|Hernandez, Vanessa\|Peralbo, Esther\|Lopez-Pedrera, Chary\|de la Haba-Rodriguez, Juan\|Aranda, Enrique\|Rodriguez-Ariza, Antonio
PMID:	26107817

259.
Journal:	Oncol Rep. 2015 Sep;34(3):1178-84.
Title:	Widdrol, a sesquiterpene isolated from Juniperus chinensis, inhibits angiogenesis by targeting vascular endothelial growth factor receptor 2 signaling.
Author:	Jin, Soojung\|Yun, Hee Jung\|Jeong, Hyun Young\|Oh, You Na\|Park, Hyun-Jin\|Yun, Seung-Geun\|Kim, Byung Woo\|Kwon, Hyun Ju
PMID:	26133679

260.
Journal:	Pathol Res Pract. 2015 Sep;211(9):665-70.
Title:	Morphological aspects of the hepatic response to neoadjuvant therapy.
Author:	Fernandez-Acenero, M J\|Cortes-Guiral, D\|Munoz, L Estrada\|Martinez-Useros, J\|Pastor-Idoate, C
PMID:	26163186

261.
Journal:	Biochem Pharmacol. 2015 Sep 1;97(1):27-37.
Title:	Vatalanib sensitizes ABCB1 and ABCG2-overexpressing multidrug resistant colon cancer cells to chemotherapy under hypoxia.
Author:	To, Kenneth K W\|Poon, Daniel C\|Wei, Yuming\|Wang, Fang\|Lin, Ge\|Fu, Li-wu
PMID:	26206183

262.
Journal:	Int J Mol Sci. 2015 Aug 10;16(8):18564-79.
Title:	Wnt3a Promotes the Vasculogenic Mimicry Formation of Colon Cancer via Wnt/beta-Catenin Signaling.
Author:	Qi, Lisha\|Song, Wangzhao\|Liu, Zhiyong\|Zhao, Xiulan\|Cao, Wenfeng\|Sun, Baocun
PMID:	26266404

263.
Journal:	MAbs. 2015;7(6):1195-204.
Title:	Anticancer activity of TTAC-0001, a fully human anti-vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) monoclonal antibody, is associated with inhibition of tumor angiogenesis.
Author:	Kim, Dong Geon\|Jin, Younggeon\|Jin, Juyoun\|Yang, Heekyoung\|Joo, Kyeung Min\|Lee, Weon Sup\|Shim, Sang Ryeol\|Kim, Sung-Woo\|Yoo, Jinsang\|Lee, Sang Hoon\|Yoo, Jin-San\|Nam, Do-Hyun
PMID:	26325365

264.
Journal:	J Biomed Opt. 2015;20(9):096015.
Title:	In vivo molecular imaging of colorectal cancer using quantum dots targeted to vascular endothelial growth factor receptor 2 and optical coherence tomography/laser-induced fluorescence dual-modality imaging.
Author:	Carbary-Ganz, Jordan L\|Welge, Weston A\|Barton, Jennifer K\|Utzinger, Urs
PMID:	26397238

265.
Journal:	Yao Xue Xue Bao. 2015 Jul;50(7):854-60.
Title:	[The anti-tumor activity and molecular mechanisms of an Aurora kinase inhibitor ZLJ213 in suppressing colon cancer growth].
Author:	Zhou, Wan-qi\|Zhang, Li-jing\|Yang, Han-ze\|Feng, Zhi-qiang\|Li, Yan
PMID:	26552147

266.
Journal:	World J Gastrointest Surg. 2015 Dec 27;7(12):356-9.
Title:	New active drugs for the treatment of advanced colorectal cancer.
Author:	Zaniboni, Alberto
PMID:	26730280

267.
Journal:	Acta Biochim Biophys Sin (Shanghai). 2016 Jan;48(1):27-38.
Title:	RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
Author:	Fang, Bingliang
PMID:	26350096

268.
Journal:	J Cell Physiol. 2016 May;231(5):1097-105.
Title:	Involvement of Notch-1 in Resistance to Regorafenib in Colon Cancer Cells.
Author:	Mirone, Giovanna\|Perna, Stefania\|Shukla, Arvind\|Marfe, Gabriella
PMID:	26419617

269.
Journal:	Tumour Biol. 2016 Mar;37(3):3871-7.
Title:	Comparison of (18)F-fluorodeoxyglucose PET/CT findings with vascular endothelial growth factors and receptors in colorectal cancer.
Author:	Kocael, Ahmet\|Vatankulu, Betul\|Simsek, Osman\|Cengiz, Mahir\|Kemik, Ahu\|Kocael, Pinar\|Halac, Metin\|Sonmezoglu, Kerim\|Ulualp, Kenan
PMID:	26476536

270.
Journal:	Tumour Biol. 2016 May;37(5):6297-306.
Title:	Does the addition of drugs targeting the vascular endothelial growth factor pathway to first-line chemotherapy increase complete response? A meta-analysis of randomized clinical trials.
Author:	Li, Yan\|Liang, Xin-Yue\|Yue, Yi-Qi\|Sheng, Lei\|Liu, Ji-Kai\|Wang, Zhan-Yu\|Chen, Gang
PMID:	26619847

271.
Journal:	Oncotarget. 2016 Feb 23;7(8):9309-21.
Title:	Does bevacizumab impact anti-EGFR therapy efficacy in metastatic colorectal cancer?
Author:	Derangere, Valentin\|Fumet, Jean David\|Boidot, Romain\|Bengrine, Leila\|Limagne, Emeric\|Chevriaux, Angelique\|Vincent, Julie\|Ladoire, Sylvain\|Apetoh, Lionel\|Rebe, Cedric\|Ghiringhelli, Francois
PMID:	26824184

272.
Journal:	Radiother Oncol. 2016 Feb;118(2):382-6.
Title:	Phase I study of pre-operative continuous 5-FU and sorafenib with external radiation therapy in locally advanced rectal adenocarcinoma.
Author:	Kim, Richard\|Prithviraj, Gopi Kesaria\|Shridhar, Ravi\|Hoffe, Sarah E\|Jiang, Kun\|Zhao, Xiuhua\|Chen, Dung-Tsa\|Almhanna, Khaldoun\|Strosberg, Jonathan\|Campos, Tiffany\|Shibata, David
PMID:	26861740

273.
Journal:	Target Oncol. 2016 Aug;11(4):479-87.
Title:	Ramucirumab Clinical Development: an Emerging Role in Gastrointestinal Tumors.
Author:	Sanchez-Gastaldo, Amparo\|Gonzalez-Exposito, Reyes\|Garcia-Carbonero, Rocio
PMID:	26887374

274.
Journal:	Expert Opin Drug Metab Toxicol. 2016;12(4):449-56.
Title:	Clinical pharmacokinetics and pharmacodynamics of ramucirumab in the treatment of colorectal cancer.
Author:	Gambardella, Valentina\|Tarazona, Noelia\|Cejalvo, Juan Miguel\|Rosello, Susana\|Cervantes, Andres
PMID:	26895445

275.
Journal:	Oncotarget. 2016 Apr 5;7(14):18837-50.
Title:	High blood sugar levels significantly impact the prognosis of colorectal cancer patients through down-regulation of microRNA-16 by targeting Myb and VEGFR2.
Author:	Yang, I-Ping\|Tsai, Hsiang-Lin\|Huang, Ching-Wen\|Lu, Chien-Yu\|Miao, Zhi-Feng\|Chang, Se-Fen\|Juo, Suh-Hang Hank\|Wang, Jaw-Yuan
PMID:	26934556

276.
Journal:	Expert Opin Investig Drugs. 2016;25(5):507-20.
Title:	Novel anti-angiogenic therapeutic strategies in colorectal cancer.
Author:	Tampellini, M\|Sonetto, C\|Scagliotti, G V
PMID:	26938715

277.
Journal:	Expert Opin Drug Saf. 2016 Jun;15(6):799-808.
Title:	The safety of monoclonal antibodies for treatment of colorectal cancer.
Author:	Berger, Martin D\|Lenz, Heinz-Josef
PMID:	26982510

278.
Journal:	Cureus. 2016 Feb 3;8(2):e478.
Title:	KDR Mutation as a Novel Predictive Biomarker of Exceptional Response to Regorafenib in Metastatic Colorectal Cancer.
Author:	Loaiza-Bonilla, Arturo\|Jensen, Christopher E\|Shroff, Stuti\|Furth, Emma\|Bonilla-Reyes, Paula A\|Deik, Andres F\|Morrissette, Jennifer
PMID:	27004155

279.
Journal:	Eur J Hum Genet. 2016 Aug;24(9):1287-93.
Title:	A novel kinase mutation in VEGFR-1 predisposes its alphaC-helix/activation loop towards allosteric activation: Atomic insights from protein simulation.
Author:	Mokhdomi, Taseem A\|Bukhari, Shoiab\|Chikan, Naveed Anjum\|Amin, Asif\|Wafai, Asrar H\|Wani, Sajad H\|Chowdri, Nisar A\|Qadri, Raies A
PMID:	27049304

280.
Journal:	Onco Targets Ther. 2016 Mar 31;9:1899-920.
Title:	Advances in targeted and immunobased therapies for colorectal cancer in the genomic era.
Author:	Seow, Heng Fong\|Yip, Wai Kien\|Fifis, Theodora
PMID:	27099521

281.
Journal:	Sci Rep. 2016 Apr 27;6:25195.
Title:	Angiogenesis genotyping and clinical outcome during regorafenib treatment in metastatic colorectal cancer patients.
Author:	Giampieri, Riccardo\|Salvatore, Lisa\|Del Prete, Michela\|Prochilo, Tiziana\|D'Anzeo, Marco\|Loretelli, Cristian\|Loupakis, Fotios\|Aprile, Giuseppe\|Maccaroni, Elena\|Andrikou, Kalliopi\|Bianconi, Maristella\|Bittoni, Alessandro\|Faloppi, Luca\|Demurtas, Laura\|Montir
PMID:	27117754

282.
Journal:	Expert Rev Clin Pharmacol. 2016 Jul;9(7):877-85.
Title:	Ramucirumab for the treatment of gastric cancers, colorectal adenocarcinomas, and other gastrointestinal malignancies.
Author:	Aprile, Giuseppe\|Ferrari, Laura\|Cremolini, Chiara\|Bergamo, Francesca\|Fontanella, Caterina\|Battaglin, Francesca\|Rihawi, Karim\|Lonardi, Sara\|Loupakis, Fotios\|Scartozzi, Mario
PMID:	27149032

283.
Journal:	Int J Mol Epidemiol Genet. 2016 Mar 23;7(1):45-57. eCollection 2016.
Title:	Genes, environment and gene expression in colon tissue: a pathway approach to determining functionality.
Author:	Slattery, Martha L\|Pellatt, Daniel F\|Wolff, Roger K\|Lundgreen, Abbie
PMID:	27186328

284.
Journal:	Cancer Res. 2016 Jul 15;76(14):4081-9.
Title:	VEGFR2-Targeted Three-Dimensional Ultrasound Imaging Can Predict Responses to Antiangiogenic Therapy in Preclinical Models of Colon Cancer.
Author:	Zhou, Jianhua\|Wang, Huaijun\|Zhang, Huiping\|Lutz, Amelie M\|Tian, Lu\|Hristov, Dimitre\|Willmann, Jurgen K
PMID:	27206846

285.
Journal:	Genes Chromosomes Cancer. 2016 Nov;55(11):821-33.
Title:	Copy number changes of clinically actionable genes in melanoma, non-small cell lung cancer and colorectal cancer-A survey across 822 routine diagnostic cases.
Author:	Pfarr, Nicole\|Penzel, Roland\|Klauschen, Frederick\|Heim, Daniel\|Brandt, Regine\|Kazdal, Daniel\|Jesinghaus, Moritz\|Herpel, Esther\|Schirmacher, Peter\|Warth, Arne\|Weichert, Wilko\|Endris, Volker\|Stenzinger, Albrecht
PMID:	27218826

286.
Journal:	Anticancer Res. 2016 Jun;36(6):2683-96.
Title:	Heterogeneity of Vascular Endothelial Growth Factor Receptors 1, 2, 3 in Primary Human Colorectal Carcinoma.
Author:	Nasir, Aejaz\|Reising, Leslie O'Neill\|Nedderman, Drew M\|Fulford, Angie D\|Uhlik, Mark T\|Benjamin, Laura E\|Schade, Andrew E\|Holzer, Timothy R
PMID:	27272777

287.
Journal:	Int J Oncol. 2016 Aug;49(2):639-45.
Title:	Rifaximin, a non-absorbable antibiotic, inhibits the release of pro-angiogenic mediators in colon cancer cells through a pregnane X receptor-dependent pathway.
Author:	Esposito, Giuseppe\|Gigli, Stefano\|Seguella, Luisa\|Nobile, Nicola\|D'Alessandro, Alessandra\|Pesce, Marcella\|Capoccia, Elena\|Steardo, Luca\|Cirillo, Carla\|Cuomo, Rosario\|Sarnelli, Giovanni
PMID:	27279570

288.
Journal:	Biomed Pharmacother. 2016 Oct;83:212-220.
Title:	Synergistic inhibition of sunitinib and ethaselen against human colorectal cancer cells proliferation.
Author:	Zheng, Xiaoqing\|Zhang, Yunhan\|Zhang, Lei\|Xu, Wei\|Ma, Weiwei\|Sun, Ruoxuan\|Zeng, Huihui
PMID:	27372405

289.
Journal:	Clin Cancer Res. 2016 Oct 15;22(20):5058-5067.
Title:	BATON-CRC: A Phase II Randomized Trial Comparing Tivozanib Plus mFOLFOX6 with Bevacizumab Plus mFOLFOX6 in Stage IV Metastatic Colorectal Cancer.
Author:	Benson, Al B 3rd\|Kiss, Igor\|Bridgewater, John\|Eskens, Ferry A L M\|Sasse, Carolyn\|Vossen, Sandra\|Chen, Jihong\|Van Sant, Chip\|Ball, Howard A\|Keating, Anne\|Krivoshik, Andrew
PMID:	27401244

290.
Journal:	Oncol Rep. 2016 Sep;36(3):1526-34.
Title:	A taspine derivative supresses Caco-2 cell growth by competitively targeting EphrinB2 and regulating its pathway.
Author:	Dai, Bingling\|Wang, Wenjie\|Ma, Yujiao\|Liu, Rui\|Zhang, Yanmin
PMID:	27460008

291.
Journal:	Case Rep Oncol. 2016 Jun 10;9(2):317-20.
Title:	A Case Report of Ischemic Stroke in a Patient with Metastatic Gastric Cancer Secondary to Treatment with the Vascular Endothelial Growth Factor Receptor-2 Inhibitor Ramucirumab.
Author:	Christiansen, Michael E\|Ingall, Timothy\|Lew, Edward C\|Ramanathan, Ramesh K\|Paripati, Harshita R
PMID:	27462231

292.
Journal:	Oncotarget. 2016 Sep 27;7(39):63124-63137.
Title:	DDA suppresses angiogenesis and tumor growth of colorectal cancer in vivo through decreasing VEGFR2 signaling.
Author:	Huang, Shiu-Wen\|Lien, Jin-Cherng\|Kuo, Sheng-Chu\|Huang, Tur-Fu
PMID:	27517319

293.
Journal:	Med Oncol. 2016 Oct;33(10):106.
Title:	Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing.
Author:	Jauhri, Mayank\|Bhatnagar, Akanksha\|Gupta, Satish\|Shokeen, Yogender\|Minhas, Sachin\|Aggarwal, Shyam
PMID:	27568332

294.
Journal:	Oncotarget. 2016 Oct 18;7(42):68571-68584.
Title:	Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model.
Author:	Williamson, Tara\|Bai, Ren-Yuan\|Staedtke, Verena\|Huso, David\|Riggins, Gregory J
PMID:	27612418

295.
Journal:	Cancer Res. 2016 Dec 1;76(23):6988-7000.
Title:	Efficacy of Cotargeting Angiopoietin-2 and the VEGF Pathway in the Adjuvant Postsurgical Setting for Early Breast, Colorectal, and Renal Cancers.
Author:	Wu, Florence T H\|Man, Shan\|Xu, Ping\|Chow, Annabelle\|Paez-Ribes, Marta\|Lee, Christina R\|Pirie-Shepherd, Steven R\|Emmenegger, Urban\|Kerbel, Robert S
PMID:	27651308

296.
Journal:	Oncol Lett. 2016 Oct;12(4):2828-2834.
Title:	4-isothiocyanate-2, 2, 6, 6-tetramethyl piperidinooxyl inhibits angiogenesis by suppressing VEGFR2 and Tie2 phosphorylation.
Author:	Liu, Yuanyuan\|Gao, Jing\|Huang, Shuangsheng\|Hu, Lamei\|Wang, Zhiqiang\|Wang, Zheyuan\|Chen, Xiao\|Zhang, Xiaoyu\|Li, Wenguang
PMID:	27698866

297.
Journal:	Oncol Rep. 2016 Dec;36(6):3635-3642.
Title:	Effect of colorectal cancer on the number of normal stem cells circulating in peripheral blood.
Author:	Marlicz, Wojciech\|Sielatycka, Katarzyna\|Serwin, Karol\|Kubis, Ewa\|Tkacz, Marta\|Gluszko, Rafal\|Bialek, Andrzej\|Starzynska, Teresa\|Ratajczak, Mariusz Z
PMID:	27779706

298.
Journal:	Chem Pharm Bull (Tokyo). 2016;64(12):1747-1754.
Title:	Novel Sulfonamide Derivatives Carrying a Biologically Active 3,4-Dimethoxyphenyl Moiety as VEGFR-2 Inhibitors.
Author:	Ghorab, Mostafa Mohammed\|Alsaid, Mansour Sulaiman\|Nissan, Yassin Mohammed\|Ashour, Abdelkader Elbadawy\|Al-Mishari, Abdullah Abdulalrahman\|Kumar, Ashok\|Ahmed, Sheikh Fayaz
PMID:	27904083

299.
Journal:	Radiology. 2017 Feb;282(2):443-452.
Title:	Intra-Animal Comparison between Three-dimensional Molecularly Targeted US and Three-dimensional Dynamic Contrast-enhanced US for Early Antiangiogenic Treatment Assessment in Colon Cancer.
Author:	Wang, Huaijun\|Lutz, Amelie M\|Hristov, Dimitre\|Tian, Lu\|Willmann, Jurgen K
PMID:	27490690

300.
Journal:	Cell Signal. 2017 Jan;29:52-61.
Title:	Targeting acid sphingomyelinase with anti-angiogenic chemotherapy.
Author:	Jacobi, Jeanna\|Garcia-Barros, Monica\|Rao, Shyam\|Rotolo, Jimmy A\|Thompson, Chris\|Mizrachi, Aviram\|Feldman, Regina\|Manova, Katia\|Bielawska, Alicja\|Bielawska, Jacek\|Fuks, Zvi\|Kolesnick, Richard\|Haimovitz-Friedman, Adriana
PMID:	27702691

301.
Journal:	Oncotarget. 2017 Jan 31;8(5):7753-7765.
Title:	NHERF1 regulates the progression of colorectal cancer through the interplay with VEGFR2 pathway.
Author:	Gu, Yanan\|Yu, Hefen\|Hao, Chengcheng\|Martin, Tracey A\|Hargest, Rachel\|He, Junqi\|Cheng, Shan\|Jiang, Wen G
PMID:	27999191

302.
Journal:	Oncotarget. 2017 Jan 17;8(3):5135-5148.
Title:	CCL24 contributes to HCC malignancy via RhoB- VEGFA-VEGFR2 angiogenesis pathway and indicates poor prognosis.
Author:	Jin, Lei\|Liu, Wei-Ren\|Tian, Meng-Xin\|Jiang, Xi-Fei\|Wang, Han\|Zhou, Pei-Yun\|Ding, Zhen-Bin\|Peng, Yuan-Fei\|Dai, Zhi\|Qiu, Shuang-Jian\|Zhou, Jian\|Fan, Jia\|Shi, Ying-Hong
PMID:	28042950

303.
Journal:	Biomed Pharmacother. 2017 Mar;87:102-109.
Title:	Taspine derivative 12k suppressed A549 cell migration through the Wnt/beta-catenin and EphrinB2 signaling pathway.
Author:	Dai, Bingling\|Ma, Yujiao\|Yang, Tianfeng\|Wang, Wenjie\|Zhang, Yanmin
PMID:	28049091

304.
Journal:	PLoS One. 2017 Jan 6;12(1):e0169323.
Title:	Contrast-Enhanced Ultrasound with VEGFR2-Targeted Microbubbles for Monitoring Regorafenib Therapy Effects in Experimental Colorectal Adenocarcinomas in Rats with DCE-MRI and Immunohistochemical Validation.
Author:	Eschbach, Ralf Stefan\|Clevert, Dirk-Andre\|Hirner-Eppeneder, Heidrun\|Ingrisch, Michael\|Moser, Matthias\|Schuster, Jessica\|Tadros, Dina\|Schneider, Moritz\|Kazmierczak, Philipp Maximilian\|Reiser, Maximilian\|Cyran, Clemens C
PMID:	28060884

305.
Journal:	Drug Des Devel Ther. 2017 Jan 11;11:177-184.
Title:	Immunotherapy for the treatment of colorectal tumors: focus on approved and in-clinical-trial monoclonal antibodies.
Author:	Francoso, Alex\|Simioni, Patricia Ucelli
PMID:	28138221

306.
Journal:	Chem Pharm Bull (Tokyo). 2017;65(3):236-247.
Title:	Design and Synthesis of Pyridazine Containing Compounds with Promising Anticancer Activity.
Author:	Elmeligie, Salwa\|Ahmed, Eman Mohamed\|Abuel-Maaty, Suzan Mohamed\|Zaitone, Sawsan Abo-Bakr\|Mikhail, Demiana Samir
PMID:	28250345

307.
Journal:	Mol Imaging Biol. 2017 Dec;19(6):847-856.
Title:	Validation of Bevacizumab Therapy Effect on Colon Cancer Subtypes by Using Whole Body Imaging in Mice.
Author:	Vuletic, Ivan\|Zhou, Kedi\|Li, Hui\|Bai, Huichen\|Meng, Xiangxi\|Zhu, Sihao\|Ding, Yichen\|Li, Jun\|Sun, Hongfang\|Ren, Qiushi
PMID:	28315202

308.
Journal:	Tumour Biol. 2017 Mar;39(3):1010428317692263.
Title:	Colorectal polypoid lesions and expression of vascular endothelial growth factor in a consecutive series of endoscopic and surgical patients.
Author:	Ruffolo, Cesare\|Toffolatti, Luisa\|Canal, Fabio\|Kotsafti, Andromachi\|Pagura, Giulia\|Pozza, Anna\|Campo Dell'Orto, Marta\|Ferrara, Francesco\|Massani, Marco\|Dei Tos, Angelo P\|Castoro, Carlo\|Bassi, Nicolo\|Scarpa, Marco
PMID:	28347226

309.
Journal:	Invest New Drugs. 2017 Dec;35(6):782-790.
Title:	Phase I trial and pharmacokinetic study of tanibirumab, a fully human monoclonal antibody to vascular endothelial growth factor receptor 2, in patients with refractory solid tumors.
Author:	Lee, Su Jin\|Lee, Seon Young\|Lee, Weon Sup\|Yoo, Jin San\|Sun, Jong-Mu\|Lee, Jeeyun\|Park, Se Hoon\|Park, Joon Oh\|Ahn, Myung-Ju\|Lim, Ho Yeong\|Kang, Won Ki\|Park, Young Suk
PMID:	28391576

310.
Journal:	Oncoimmunology. 2017 Feb 17;6(3):e1290038.
Title:	Anti-VEGFR2-interferon-alpha2 regulates the tumor microenvironment and exhibits potent antitumor efficacy against colorectal cancer.
Author:	Li, Zhaoting\|Zhu, Yijia\|Li, Chenchen\|Trinh, Ryan\|Ren, Xueyan\|Sun, Fumou\|Wang, Youfu\|Shang, Pengzhao\|Wang, Tong\|Wang, Min\|Morrison, Sherie L\|Zhang, Juan
PMID:	28405526

311.
Journal:	Nutr Res. 2017 May;41:36-46.
Title:	Secretion metabolites of probiotic yeast, Pichia kudriavzevii AS-12, induces apoptosis pathways in human colorectal cancer cell lines.
Author:	Saber, Amir\|Alipour, Beitollah\|Faghfoori, Zeinab\|Mousavi Jam, Ali\|Yari Khosroushahi, Ahmad
PMID:	28477945

312.
Journal:	Pathol Res Pract. 2017 Jun;213(6):639-642.
Title:	CPEB4 immunohistochemical expression is associated to prognosis in stage IV colorectal carcinoma.
Author:	Cortes-Guiral, D\|Pastor-Iodate, C\|Diaz Del Arco, C\|Del Puerto-Nevado, L\|Fernandez-Acenero, M J
PMID:	28551384

313.
Journal:	PLoS One. 2017 Jun 8;12(6):e0179202.
Title:	Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1alpha and VEGF receptors.
Author:	Mahfouz, Nadine\|Tahtouh, Roula\|Alaaeddine, Nada\|El Hajj, Joelle\|Sarkis, Riad\|Hachem, Ray\|Raad, Issam\|Hilal, George
PMID:	28594907

314.
Journal:	Expert Opin Pharmacother. 2017 Aug;18(11):1153-1162.
Title:	The potential role of nintedanib in treating colorectal cancer.
Author:	Rossi, Antonio\|Latiano, Tiziana Pia\|Parente, Paola\|Chiarazzo, Cinzia\|Limosani, Filomena\|Di Maggio, Gabriele\|Maiello, Evaristo
PMID:	28649871

315.
Journal:	J Clin Invest. 2017 Aug 1;127(8):3039-3051.
Title:	Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.
Author:	Jung, Keehoon\|Heishi, Takahiro\|Khan, Omar F\|Kowalski, Piotr S\|Incio, Joao\|Rahbari, Nuh N\|Chung, Euiheon\|Clark, Jeffrey W\|Willett, Christopher G\|Luster, Andrew D\|Yun, Seok Hyun\|Langer, Robert\|Anderson, Daniel G\|Padera, Timothy P\|Jain, Rakesh K\|Fukumura, Da
PMID:	28691930

316.
Journal:	Br J Cancer. 2017 Sep 5;117(6):848-855.
Title:	Intracrine VEGF signalling mediates colorectal cancer cell migration and invasion.
Author:	Bhattacharya, Rajat\|Fan, Fan\|Wang, Rui\|Ye, Xiangcang\|Xia, Ling\|Boulbes, Delphine\|Ellis, Lee M
PMID:	28742793

317.
Journal:	Biomed Pharmacother. 2017 Nov;95:68-76.
Title:	Catalpol suppressed proliferation, growth and invasion of CT26 colon cancer by inhibiting inflammation and tumor angiogenesis.
Author:	Zhu, Pingting\|Wu, Yu\|Yang, Aihua\|Fu, Xingsheng\|Mao, Ming\|Liu, Zhaoguo
PMID:	28826099

318.
Journal:	BMC Cancer. 2017 Aug 30;17(1):593.
Title:	VEGFR2 regulates endothelial differentiation of colon cancer cells.
Author:	Liu, Zhiyong\|Qi, Lisha\|Li, Yixian\|Zhao, Xiulan\|Sun, Baocun
PMID:	28854900

319.
Journal:	Mar Drugs. 2017 Sep 4;15(9). pii: md15090283.
Title:	Potential Application of Eicosapentaenoic Acid Monoacylglyceride in the Management of Colorectal Cancer.
Author:	Morin, Caroline\|Rodriguez, Enrique\|Blier, Pierre U\|Fortin, Samuel
PMID:	28869531

320.
Journal:	Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10455-10460.
Title:	Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer.
Author:	Jung, Keehoon\|Heishi, Takahiro\|Incio, Joao\|Huang, Yuhui\|Beech, Elizabeth Y\|Pinter, Matthias\|Ho, William W\|Kawaguchi, Kosuke\|Rahbari, Nuh N\|Chung, Euiheon\|Kim, Jun Ki\|Clark, Jeffrey W\|Willett, Christopher G\|Yun, Seok Hyun\|Luster, Andrew D\|Padera, Timothy P
PMID:	28900008

321.
Journal:	Oncotarget. 2017 Mar 14;8(35):58152-58162.
Title:	Sialyllactose suppresses angiogenesis by inhibiting VEGFR-2 activation, and tumor progression.
Author:	Chung, Tae-Wook\|Kim, Eun-Young\|Kim, Seok-Jo\|Choi, Hee-Jung\|Jang, Se Bok\|Kim, Keuk-Jun\|Ha, Sun-Hyung\|Abekura, Fukushi\|Kwak, Choong-Hwan\|Kim, Cheorl-Ho\|Ha, Ki-Tae
PMID:	28938544

322.
Journal:	Int J Environ Res Public Health. 2017 Sep 28;14(10). pii: ijerph14101146.
Title:	Multiple Gene-Environment Interactions on the Angiogenesis Gene-Pathway Impact Rectal Cancer Risk and Survival.
Author:	Sharafeldin, Noha\|Slattery, Martha L\|Liu, Qi\|Franco-Villalobos, Conrado\|Caan, Bette J\|Potter, John D\|Yasui, Yutaka
PMID:	28956832

323.
Journal:	Adv Exp Med Biol. 2017;1018:207-224.
Title:	Prion Protein Family Contributes to Tumorigenesis via Multiple Pathways.
Author:	Yang, Xiaowen\|Cheng, Zhijun\|Zhang, Lihua\|Wu, Guiru\|Shi, Run\|Gao, Zhenxing\|Li, Chaoyang
PMID:	29052140

324.
Journal:	Anticancer Agents Med Chem. 2018 Feb 7;17(14):1931-1941.
Title:	Synthesis, Characterization of 4-Anilino-6,7-Dimethoxy Quinazoline Derivatives as Potential Anti-Angiogenic Agents.
Author:	Devegowda, Preethi Saligrama\|Balaji, Kyathegowdanadoddi Srinivasa\|Prasanna, Doddakunche Shivaramu\|Swaroop, Toreshettahally Ramesh\|Kameshwar, Vivek Hamse\|Jayarama, Shankar\|Siddalingaiah, Lokesh\|Rangappa, Kanchugarakoppal Subbegowda
PMID:	28403784

325.
Journal:	Endosc Ultrasound. 2018 May-Jun;7(3):175-183.
Title:	Assessing tumor angiogenesis in colorectal cancer by quantitative contrast-enhanced endoscopic ultrasound and molecular and immunohistochemical analysis.
Author:	Cartana, Elena-Tatiana\|Gheonea, Dan Ionut\|Cherciu, Irina Florina\|Streata, Ioana\|Uscatu, Constantin-Daniel\|Nicoli, Elena-Raluca\|Ioana, Mihai\|Pirici, Daniel\|Georgescu, Claudia-Valentina\|Alexandru, Dragos-Ovidiu\|Surlin, Valeriu\|Gruionu, Gabriel\|Saftoiu, Adri
PMID:	28685747

326.
Journal:	Oncogene. 2018 Feb 1;37(5):601-615.
Title:	The extracellular matrix protein mindin attenuates colon cancer progression by blocking angiogenesis via Egr-1-mediated regulation.
Author:	Wang, L-F\|Liu, Y-S\|Yang, B\|Li, P\|Cheng, X-S\|Xiao, C-X\|Liu, J-J\|Li, S\|Ren, J-L\|Guleng, B
PMID:	28991232

327.
Journal:	Anticancer Agents Med Chem. 2018;18(4):583-590.
Title:	Oleanolic Acid Inhibits Colorectal Cancer Angiogenesis by Blocking the VEGFR2 Signaling Pathway.
Author:	Niu, Guoping\|Sun, Li\|Pei, Yunfeng\|Wang, Duping
PMID:	29065844

328.
Journal:	Expert Rev Anticancer Ther. 2018 Mar;18(3):251-266.
Title:	The role of tumor angiogenesis as a therapeutic target in colorectal cancer.
Author:	Battaglin, Francesca\|Puccini, Alberto\|Intini, Rossana\|Schirripa, Marta\|Ferro, Alessandra\|Bergamo, Francesca\|Lonardi, Sara\|Zagonel, Vittorina\|Lenz, Heinz-Josef\|Loupakis, Fotios
PMID:	29338550

329.
Journal:	Oncol Rep. 2018 May;39(5):2385-2392.
Title:	IgG response to MHC class I epitope peptides is a quantitative predictive biomarker in the early course of treatment of colorectal cancer using therapeutic peptides.
Author:	Kanekiyo, Shinsuke\|Hazama, Shoichi\|Takenouchi, Hiroko\|Nakajima, Masao\|Shindo, Yoshitaro\|Matsui, Hiroto\|Tokumitsu, Yukio\|Tomochika, Shinobu\|Tsunedomi, Ryouichi\|Tokuhisa, Yoshihiro\|Iida, Michihisa\|Sakamoto, Kazuhiko\|Suzuki, Nobuaki\|Takeda, Shigeru\|Yamamoto,
PMID:	29498403

330.
Journal:	Clin Cancer Res. 2018 Aug 1;24(15):3550-3559.
Title:	Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies.
Author:	Toledo, Rodrigo A\|Garralda, Elena\|Mitsi, Maria\|Pons, Tirso\|Monsech, Jorge\|Vega, Estela\|Otero, Alvaro\|Albarran, Maria I\|Banos, Natalia\|Duran, Yolanda\|Bonilla, Victoria\|Sarno, Francesca\|Camacho-Artacho, Marta\|Sanchez-Perez, Tania\|Perea, Sofia\|Alvarez, Rafae
PMID:	29588308

331.
Journal:	Clin Colorectal Cancer. 2018 Sep;17(3):e471-e488.
Title:	Prognostic Value of ACVRL1 Expression in Metastatic Colorectal Cancer Patients Receiving First-line Chemotherapy With Bevacizumab: Results From the Triplet Plus Bevacizumab (TRIBE) Study.
Author:	Hanna, Diana L\|Loupakis, Fotios\|Yang, Dongyun\|Cremolini, Chiara\|Schirripa, Marta\|Li, Meng\|Matsusaka, Satoshi\|Berger, Martin D\|Miyamoto, Yuji\|Zhang, Wu\|Ning, Yan\|Antoniotti, Carlotta\|Salvatore, Lisa\|Moran, Miriana\|Zeger, Gary\|Astrow, Stephanie H\|Falcone, A
PMID:	29636300

332.
Journal:	Sci Rep. 2018 May 8;8(1):7238.
Title:	Molecular targets of Chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology.
Author:	Zhu, Hongxu\|Hao, Jian\|Niu, Yangyang\|Liu, Dan\|Chen, Dan\|Wu, Xiongzhi
PMID:	29740162

333.
Journal:	Ann Coloproctol. 2018 Apr;34(2):88-93.
Title:	Association Between c-Met and Lymphangiogenic Factors in Patients With Colorectal Cancer.
Author:	Kim, Han Jo\|Baek, Moo-Jun\|Kang, Dong Hyun\|Lee, Sang-Cheol\|Bae, Sang Byung\|Lee, Kyu Taek\|Lee, Namsu\|Kim, Hyungjoo\|Jeong, Dongjun\|Ahn, Tae Sung\|Lee, Moon Soo\|Hong, Dae Sik\|Won, Jong-Ho
PMID:	29742856

334.
Journal:	Oncotarget. 2018 May 8;9(35):23960-23974.
Title:	Identification of different mutational profiles in cancers arising in specific colon segments by next generation sequencing.
Author:	Oliveira, Duarte Mendes\|Laudanna, Carmelo\|Migliozzi, Simona\|Zoppoli, Pietro\|Santamaria, Gianluca\|Grillone, Katia\|Elia, Laura\|Mignogna, Chiara\|Biamonte, Flavia\|Sacco, Rosario\|Corcione, Francesco\|Viglietto, Giuseppe\|Malanga, Donatella\|Rizzuto, Antonia
PMID:	29844865

335.
Journal:	Medicine (Baltimore). 2018 Jun;97(25):e11178.
Title:	Unexpected and durable response with regorafenib in a metastatic colorectal cancer patient without KDR mutation: A case report.
Author:	Rosati, Gerardo\|Del Gaudio, Nunzio\|Scarano, Enrico\|Cifarelli, Rosa Anna\|Altucci, Lucia\|Bilancia, Domenico
PMID:	29924031

336.
Journal:	JAMA. 2018 Jun 26;319(24):2486-2496.
Title:	Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic Colorectal Cancer: The FRESCO Randomized Clinical Trial.
Author:	Li, Jin\|Qin, Shukui\|Xu, Rui-Hua\|Shen, Lin\|Xu, Jianming\|Bai, Yuxian\|Yang, Lei\|Deng, Yanhong\|Chen, Zhen-Dong\|Zhong, Haijun\|Pan, Hongming\|Guo, Weijian\|Shu, Yongqian\|Yuan, Ying\|Zhou, Jianfeng\|Xu, Nong\|Liu, Tianshu\|Ma, Dong\|Wu, Changping\|Cheng, Ying\|Chen, Dong
PMID:	29946728

337.
Journal:	Biochem Cell Biol. 2018 Jun 29.
Title:	ATAD2 silencing decreases VEGFA secretion through targeting has-miR-520a to inhibit angiogenesis in colorectal cancer.
Author:	Hong, Sen\|Chen, Si\|Wang, Xu\|Sun, Di\|Yan, Zhenkun\|Tai, Jiandong\|Bi, Miaomiao
PMID:	29958090

338.
Journal:	Acta Pharmacol Sin. 2018 Jul 5. pii: 10.1038/s41401-018-0058-y.
Title:	Apatinib, a selective VEGFR2 inhibitor, improves the delivery of chemotherapeutic agents to tumors by normalizing tumor vessels in LoVo colon cancer xenograft mice.
Author:	Zhou, Kai\|Zhang, Jing-Wei\|Wang, Qi-Zhi\|Liu, Wen-Yue\|Liu, Jia-Li\|Yao, Lan\|Cai, Ming-Min\|Ni, Sui-Ying\|Cai, Qing-Yun\|Wang, Guang-Ji\|Zhou, Fang
PMID:	29977004

339.
Journal:	Mol Cancer Ther. 2018 Jul 19. pii: 1535-7163.MCT-17-0131.
Title:	Cabozantinib exhibits potent antitumor activity in colorectal cancer patient-derived tumor xenograft models via autophagy and signaling mechanisms.
Author:	Scott, Aaron J\|Arcaroli, John J\|Bagby, Stacey M\|Yahn, Rachel\|Huber, Kendra M\|Serkova, Natalie J\|Nguyen, Anna\|Kim, Jihye\|Thorburn, Andrew\|Vogel, Jon\|Quackenbush, Kevin S\|Capasso, Anna\|Schreiber, Anna\|Blatchford, Patrick\|Klauck, Peter J\|Pitts, Todd M\|Eckhar
PMID:	30026382

340.
Journal:	Anticancer Drugs. 2018 Oct;29(9):827-838.
Title:	Dual compartmental targeting of cell cycle and angiogenic kinases in colorectal cancer models.
Author:	Capasso, Anna\|Pitts, Todd M\|Klauck, Peter J\|Bagby, Stacey M\|Westbrook, Lindsey\|Kaplan, Jeffrey\|Soleimani, Milad\|Spreafico, Anna\|Tentler, John J\|Diamond, Jennifer R\|Arcaroli, John J\|Messersmith, Wells A\|Eckhardt, Sue G\|Leong, Stephen
PMID:	30048249

341.
Journal:	Expert Opin Drug Saf. 2018 Sep;17(9):945-951.
Title:	The safety of ramucirumab for the treatment of colorectal cancer.
Author:	Noguerido, Alba\|Mulet-Margalef, Nuria\|Matos, Ignacio\|Ros, Javier\|Argiles, Guillem\|Elez, Elena\|Tabernero, Josep
PMID:	30073902

342.
Journal:	ChemMedChem. 2018 Sep 19;13(18):1895-1908.
Title:	Synthesis, Computational Docking Study, and Biological Evaluation of a Library of Heterocyclic Curcuminoids with Remarkable Antitumor Activity.
Author:	Laali, Kenneth K\|Greves, William J\|Zwarycz, Angela T\|Correa Smits, Sebastian J\|Troendle, Frederick J\|Borosky, Gabriela L\|Akhtar, Sharoon\|Manna, Alak\|Paulus, Aneel\|Chanan-Khan, Asher\|Nukaya, Manabu\|Kennedy, Gregory D
PMID:	30079563

343.
Journal:	Cancer Sci. 2018 Aug 27.
Title:	Bevacizumab-enhanced antitumor effect of 5-fluorouracil via upregulation of thymidine phosphorylase through vascular endothelial growth factor A/vascular endothelial growth factor receptor 2-specificity protein 1 pathway.
Author:	Liu, Wenyue\|Zhang, Jingwei\|Yao, Xuequan\|Jiang, Chao\|Ni, Ping\|Cheng, Lingge\|Liu, Jiali\|Ni, Suiying\|Chen, Qianying\|Li, Qingran\|Zhou, Kai\|Wang, Guangji\|Zhou, Fang
PMID:	30151975

344.
Journal:	J Control Release. 2018 Sep 11;288:161-172.
Title:	Light-enhanced VEGF121/rGel: A tumor targeted modality with vascular and immune-mediated efficacy.
Author:	Weyergang, Anette\|Fremstedal, Ane S\|Skarpen, Ellen\|Peng, Qian\|Mohamedali, Khalid A\|Eng, Marius S\|Cheung, Lawrence H\|Rosenblum, Michael G\|Waltenberger, Johannes\|Berg, Kristian
PMID:	30217739

345.
Journal:	Zhonghua Yi Xue Za Zhi. 2018 Sep 11;98(34):2737-2742.
Title:	[The impact of genetic variation of KDR on clinical outcomes of advanced colorectal cancer patients treated by first line bevacizumab based regimens].
Author:	Wang, H X\|Mei, X\|Gong, T X\|Han, N\|Liu, P\|Wang, J\|Zhang, Z M
PMID:	30220171

346.
Journal:	Mol Imaging Biol. 2018 Sep 17. pii: 10.1007/s11307-018-1274-z.
Title:	Pharmacokinetic Modeling of Targeted Ultrasound Contrast Agents for Quantitative Assessment of Anti-Angiogenic Therapy: a Longitudinal Case-Control Study in Colon Cancer.
Author:	Turco, Simona\|El Kaffas, Ahmed\|Zhou, Jianhua\|Lutz, Amelie M\|Wijkstra, Hessel\|Willmann, Jurgen K\|Mischi, Massimo
PMID:	30225758

347.
Journal:	Front Chem. 2018 Aug 23;6:373.
Title:	Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer.
Author:	Mioc, Marius\|Avram, Sorin\|Bercean, Vasile\|Kurunczi, Ludovic\|Ghiulai, Roxana M\|Oprean, Camelia\|Coricovac, Dorina E\|Dehelean, Cristina\|Mioc, Alexandra\|Balan-Porcarasu, Mihaela\|Tatu, Calin\|Soica, Codruta
PMID:	30234098

348.
Journal:	Cell Death Dis. 2018 Sep 24;9(10):982.
Title:	SP1-induced lncRNA-ZFAS1 contributes to colorectal cancer progression via the miR-150-5p/VEGFA axis.
Author:	Chen, Xiaoxiang\|Zeng, Kaixuan\|Xu, Mu\|Hu, Xiuxiu\|Liu, Xiangxiang\|Xu, Tao\|He, Bangshun\|Pan, Yuqin\|Sun, Huiling\|Wang, Shukui
PMID:	30250022

349.
Journal:	Arch Virol. 2018 Sep 26. pii: 10.1007/s00705-018-4026-0.
Title:	Suppression of angiogenesis and tumor growth by recombinant T4 phages displaying extracellular domain of vascular endothelial growth factor receptor 2.
Author:	Zuo, Shuguang\|Dai, Gongpeng\|Wang, Liping\|Wen, Yuqing\|Huang, Zhiang\|Yang, Wenyi\|Ma, Wanli\|Ren, Xuequn
PMID:	30259141

350.
Journal:	J Biomed Nanotechnol. 2018 Dec 1;14(12):2077-2091.
Title:	Oral Administration of Liposome-Apatinib and Locally Delivery of Docetaxel/MPEG-PCL by Fibrin Glue Synergistically Improve Therapeutic Effect in Colorectal Cancer.
Author:	Yu, Ting\|Wu, Cong\|Zhu, Changhui\|He, Yihong\|Yang, Daoke\|Cheng, Yongzhong\|Gao, Xiang
PMID:	30305215