Primary Site >> Liver Cancer

Gene >> JAK2

Journal: J Biol Chem. 1998 Sep 25;273(39):25510-5.
Title: HBx protein of hepatitis B virus activates Jak1-STAT signaling.
Author: Lee, Y H|Yun, Y
PMID: 9738022
Journal: Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1016-21.
Title: Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2.
Author: Leung, K C|Doyle, N|Ballesteros, M|Sjogren, K|Watts, C K W|Low, T H|Leong, G M|Ross, R J M|Ho, K K Y
PMID: 12552091
Journal: Toxicol Appl Pharmacol. 2003 May 1;188(3):185-98.
Title: Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643.
Author: Vanden Heuvel, John P|Kreder, Dirk|Belda, Benjamin|Hannon, Daniel B|Nugent, Courtney A|Burns, Katherine A|Taylor, Michael J
PMID: 12729718
Journal: Oncogene. 2005 Sep 22;24(42):6406-17.
Title: Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma.
Author: Niwa, Yasuharu|Kanda, Hiroaki|Shikauchi, Yuko|Saiura, Akio|Matsubara, Kenichi|Kitagawa, Tomoyuki|Yamamoto, Junji|Kubo, Takahiko|Yoshikawa, Hirohide
PMID: 16007195
Journal: Endocr Relat Cancer. 2007 Jun;14(2):513-29.
Title: Leptin induces proliferation and anti-apoptosis in human hepatocarcinoma cells by up-regulating cyclin D1 and down-regulating Bax via a Janus kinase 2-linked pathway.
Author: Chen, Chiachen|Chang, Yuan-Ching|Liu, Chien-Liang|Liu, Tsang-Pai|Chang, King-Jen|Guo, Ing-Cherng
PMID: 17639064
Journal: Clin Cancer Res. 2008 Jun 15;14(12):3716-21.
Title: Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers.
Author: Jeong, Eun Goo|Kim, Min Sung|Nam, Hyo Kyung|Min, Chang Ki|Lee, Seok|Chung, Yeun Jun|Yoo, Nam Jin|Lee, Sug Hyung
PMID: 18559588
Journal: Cancer Lett. 2010 Jun 28;292(2):197-207.
Title: Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells.
Author: Li, Feng|Fernandez, Prasana Priscilla|Rajendran, Peramaiyan|Hui, Kam M|Sethi, Gautam
PMID: 20053498
Journal: Mol Cancer. 2010 Aug 16;9:217.
Title: A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.
Author: Lin, Li|Deangelis, Stephanie|Foust, Elizabeth|Fuchs, James|Li, Chenglong|Li, Pui-Kai|Schwartz, Eric B|Lesinski, Gregory B|Benson, Don|Lu, Jiagao|Hoyt, Dale|Lin, Jiayuh
PMID: 20712901
Journal: Br J Pharmacol. 2011 May;163(2):283-98.
Title: gamma-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent.
Author: Rajendran, Peramaiyan|Li, Feng|Manu, Kanjoormana Aryan|Shanmugam, Muthu K|Loo, Ser Yue|Kumar, Alan Prem|Sethi, Gautam
PMID: 21198544
Journal: World J Gastroenterol. 2011 Sep 14;17(34):3922-32.
Title: Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3.
Author: Gu, Fang-Ming|Li, Quan-Lin|Gao, Qiang|Jiang, Jia-Hao|Huang, Xiao-Yong|Pan, Jin-Feng|Fan, Jia|Zhou, Jian
PMID: 22025881
Journal: Mol Cancer. 2011 Dec 15;10:150.
Title: IL-17 induces AKT-dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma.
Author: Gu, Fang-Ming|Li, Quan-Lin|Gao, Qiang|Jiang, Jia-Hao|Zhu, Kai|Huang, Xiao-Yong|Pan, Jin-Feng|Yan, Jun|Hu, Jin-Hui|Wang, Zheng|Dai, Zhi|Fan, Jia|Zhou, Jian
PMID: 22171994
Journal: Cancer Prev Res (Phila). 2012 Apr;5(4):631-43.
Title: Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo.
Author: Rajendran, Peramaiyan|Li, Feng|Shanmugam, Muthu K|Kannaiyan, Radhamani|Goh, Jen Nee|Wong, Kwong Fai|Wang, Wei|Khin, Ester|Tergaonkar, Vinay|Kumar, Alan Prem|Luk, John M|Sethi, Gautam
PMID: 22369852
Journal: World J Surg. 2012 May;36(5):1128-35.
Title: Prolactin promotes hepatocellular carcinoma through Janus kinase 2.
Author: Yeh, Yao-Tsung|Lee, King-Teh|Tsai, Chia-Jung|Chen, Yu-Jie|Wang, Shen-Nien
PMID: 22392353
Journal: Cell Physiol Biochem. 2012;29(5-6):863-74.
Title: Angiotensin II induces angiogenic factors production partly via AT1/JAK2/STAT3/SOCS3 signaling pathway in MHCC97H cells.
Author: Ji, Yuanyuan|Wang, Zhidong|Li, Zongfang|Li, Ke|Le, Xiaofeng|Zhang, Ting
PMID: 22613986
Journal: Br J Pharmacol. 2013 Oct;170(4):807-21.
Title: Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3.
Author: Subramaniam, Aruljothi|Shanmugam, Muthu K|Ong, Tina H|Li, Feng|Perumal, Ekambaram|Chen, Luxi|Vali, Shireen|Abbasi, Taher|Kapoor, Shweta|Ahn, Kwang Seok|Kumar, Alan Prem|Hui, Kam M|Sethi, Gautam
PMID: 23848338
Journal: Oncoimmunology. 2013 Dec 1;2(12):e27090.
Title: Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma.
Author: Poussin, Karine|Pilati, Camilla|Couchy, Gabrielle|Calderaro, Julien|Bioulac-Sage, Paulette|Bacq, Yannick|Paradis, Valerie|Leteurtre, Emmanuelle|Sturm, Nathalie|Ramos, Jeanne|Guettier, Catherine|Bardier-Dupas, Armelle|Boulai, Anais|Wendum, Dominique|Selves
PMID: 24501689
Journal: Cancer Lett. 2013 Jan 28;328(2):243-51.
Title: Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells.
Author: Yang, Jie|Cai, Xueting|Lu, Wuguang|Hu, Chunping|Xu, Xiaojun|Yu, Qiang|Cao, Peng
PMID: 23032719
Journal: Hepatology. 2013 Feb;57(2):678-88.
Title: Estrogen-sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3.
Author: Hou, Jiajie|Xu, Juan|Jiang, Runqiu|Wang, Youjing|Chen, Chen|Deng, Lei|Huang, Xingxu|Wang, Xuehao|Sun, Beicheng
PMID: 22821478
Journal: J Huazhong Univ Sci Technolog Med Sci. 2013 Jun;33(3):339-345.
Title: Germacrone induces apoptosis in human hepatoma HepG2 cells through inhibition of the JAK2/STAT3 signalling pathway.
Author: Liu, Yun-Yi|Zheng, Qian|Fang, Bin|Wang, Wei|Ma, Feng-Yun|Roshan, Sadia|Banafa, Amal|Chen, Ming-Jie|Chang, Jun-Li|Deng, Xiao-Min|Li, Ke-Xiu|Yang, Guang-Xiao|He, Guang-Yuan
PMID: 23771657
Journal: Hepatology. 2014 Jan;59(1):178-89.
Title: Growth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma.
Author: Zhang, Li|Yang, Zhaojuan|Ma, Aihui|Qu, Yulan|Xia, Suhua|Xu, Dongxu|Ge, Chao|Qiu, Bijun|Xia, Qiang|Li, Jinjun|Liu, Yongzhong
PMID: 23897841
Journal: J Exp Clin Cancer Res. 2014 Jun 30;33:55.
Title: A novel miR-219-SMC4-JAK2/Stat3 regulatory pathway in human hepatocellular carcinoma.
Author: Zhou, Bo|Chen, Hongxu|Wei, Dong|Kuang, Yi|Zhao, Xiaobiao|Li, Guangyao|Xie, Jun|Chen, Ping
PMID: 24980149
Journal: J Biol Chem. 2014 Dec 5;289(49):34296-307.
Title: Development of a novel azaspirane that targets the Janus kinase-signal transducer and activator of transcription (STAT) pathway in hepatocellular carcinoma in vitro and in vivo.
Author: Mohan, Chakrabhavi Dhananjaya|Bharathkumar, Hanumantharayappa|Bulusu, Krishna C|Pandey, Vijay|Rangappa, Shobith|Fuchs, Julian E|Shanmugam, Muthu K|Dai, Xiaoyun|Li, Feng|Deivasigamani, Amudha|Hui, Kam M|Kumar, Alan Prem|Lobie, Peter E|Bender, Andreas|Basap
PMID: 25320076
Journal: Mol Cancer. 2015 Feb 3;14:23.
Title: Male-specific hepatitis B virus large surface protein variant W4P potentiates tumorigenicity and induces gender disparity.
Author: Lee, Seoung-Ae|Kim, Hong|Won, You-Sub|Seok, Seung-Hyeok|Na, YiRang|Shin, Han-Bo|Inn, Kyung-Soo|Kim, Bum-Joon
PMID: 25645622
Journal: BMC Cancer. 2015 Nov 2;15:830.
Title: Higher proliferation of peritumoral endothelial cells to IL-6/sIL-6R than tumoral endothelial cells in hepatocellular carcinoma.
Author: Zhuang, Peng-Yuan|Wang, Jian-Dong|Tang, Zhao-Hui|Zhou, Xue-Ping|Quan, Zhi-Wei|Liu, Ying-Bin|Shen, Jun
PMID: 26525581
Journal: Oncotarget. 2015 Oct 13;6(31):31927-43.
Title: A novel anti-cancer agent Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6/Jak2/Stat3 pathway.
Author: Zhao, Hong|Guo, Yuming|Li, Shu|Han, Ruiqin|Ying, Jianming|Zhu, Hai|Wang, Yuanyuan|Yin, Li|Han, Yuqing|Sun, Lingzhi|Wang, Zhaoyi|Lin, Qingcong|Bi, Xinyu|Jiao, Yuchen|Jia, Hongying|Zhao, Jianjun|Huang, Zhen|Li, Zhiyu|Zhou, Jianguo|Song, Wei|Meng, Kun|Cai, J
PMID: 26376676
Journal: Cancer Cell Int. 2015 Apr 21;15:45.
Title: B7-H3 promotes aggression and invasion of hepatocellular carcinoma by targeting epithelial-to-mesenchymal transition via JAK2/STAT3/Slug signaling pathway.
Author: Kang, Fu-Biao|Wang, Ling|Jia, Heng-Chuan|Li, Dong|Li, Hai-Jun|Zhang, Yin-Ge|Sun, Dian-Xing
PMID: 25908926
Journal: Oncol Rep. 2015 Feb;33(2):767-73.
Title: High expression of Janus kinase 2 in background normal liver tissue of resected hepatocellular carcinoma is associated with worse prognosis.
Author: Sonohara, Fuminori|Nomoto, Shuji|Inokawa, Yoshikuni|Hishida, Mitsuhiro|Takano, Nao|Kanda, Mitsuro|Nishikawa, Yoko|Fujii, Tsutomu|Koike, Masahiko|Sugimoto, Hiroyuki|Kodera, Yasuhiro
PMID: 25420511
Journal: Int J Oncol. 2015 Feb;46(2):587-96.
Title: Macrophage-secreted IL-8 induces epithelial-mesenchymal transition in hepatocellular carcinoma cells by activating the JAK2/STAT3/Snail pathway.
Author: Fu, Xiu-Tao|Dai, Zhi|Song, Kang|Zhang, Zhuo-Jun|Zhou, Zheng-Jun|Zhou, Shao-Lai|Zhao, Yi-Ming|Xiao, Yong-Sheng|Sun, Qi-Man|Ding, Zhen-Bin|Fan, Jia
PMID: 25405790
Journal: Oncol Lett. 2016 Nov;12(5):4252-4262.
Title: A novel curcumin analogue is a potent chemotherapy candidate for human hepatocellular carcinoma.
Author: Zhao, Ji-An|Sang, Mei-Xiang|Geng, Cui-Zhi|Wang, Shi-Jie|Shan, Bao-En
PMID: 27895800
Journal: Biomed Pharmacother. 2016 Dec;84:1202-1212.
Title: The effect of JAK2 knockout on inhibition of liver tumor growth by inducing apoptosis, autophagy and anti-proliferation via STATs and PI3K/AKT signaling pathways.
Author: Xu, Ying|Lv, Sheng-Xiang
PMID: 27788478
Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Jul;32(7):901-5.
Title: [Interferon-beta combined with all-trans retinoic acid supresses proliferation and promote apoptosis by inhibiting JAK2/STAT3 pathway in HepG2 human hepatocellular carcinoma cells].
Author: Zhao, Jian|Nie, Wenjia|Li, Wei|Zhou, Xiaohui|Sun, Huifeng|Zhu, Junqing|Chen, Jinjun|Peng, Junlu
PMID: 27363269
Journal: Oncotarget. 2016 Jul 12;7(28):43475-43491.
Title: (-)-Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma.
Author: Pei, Tiemin|Meng, Qinghui|Han, Jihua|Sun, Haobo|Li, Long|Song, Ruipeng|Sun, Boshi|Pan, Shangha|Liang, Desen|Liu, Lianxin
PMID: 27259268
Journal: Cancer Res. 2016 Jul 15;76(14):4124-35.
Title: FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 Signaling.
Author: Yang, Xuguang|Lin, Yuli|Shi, Yinghong|Li, Bingji|Liu, Weiren|Yin, Wei|Dang, Yongjun|Chu, Yiwei|Fan, Jia|He, Rui
PMID: 27216177
Journal: Am J Transl Res. 2016 Mar 15;8(3):1319-38. eCollection 2016.
Title: Overexpression of variant PNPLA3 gene at I148M position causes malignant transformation of hepatocytes via IL-6-JAK2/STAT3 pathway in low dose free fatty acid exposure: a laboratory investigation in vitro and in vivo.
Author: Liu, Zhengtao|Chen, Tianchi|Lu, Xiaoxiao|Xie, Haiyang|Zhou, Lin|Zheng, Shusen
PMID: 27186262
Journal: Mol Cell Biochem. 2016 May;416(1-2):85-97.
Title: Metastasized lung cancer suppression by Morinda citrifolia (Noni) leaf compared to Erlotinib via anti-inflammatory, endogenous antioxidant responses and apoptotic gene activation.
Author: Lim, Swee-Ling|Mustapha, Noordin M|Goh, Yong-Meng|Bakar, Nurul Ain Abu|Mohamed, Suhaila
PMID: 27106908
Journal: Oncol Rep. 2016 Apr;35(4):2461-5.
Title: Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182.
Author: Devor, Eric J|Schickling, Brandon M|Reyes, Henry D|Warrier, Akshaya|Lindsay, Brittany|Goodheart, Michael J|Santillan, Donna A|Leslie, Kimberly K
PMID: 26847831
Journal: Oncotarget. 2016 Jul 5;7(27):41445-41459.
Title: RhoE/ROCK2 regulates chemoresistance through NF-kappaB/IL-6/ STAT3 signaling in hepatocellular carcinoma.
Author: Ma, Wei|Sze, Karen Man-Fong|Chan, Lo Kong|Lee, Joyce Man-Fong|Wei, Larry Lai|Wong, Chun-Ming|Lee, Terence Kin-Wah|Wong, Carmen Chak-Lui|Ng, Irene Oi-Lin
PMID: 27213590
Journal: Oncol Lett. 2017 Dec;14(6):7571-7576.
Title: Mucin 1 promotes radioresistance in hepatocellular carcinoma cells through activation of JAK2/STAT3 signaling.
Author: Yi, Feng-Tao|Lu, Qi-Ping
PMID: 29344203
Journal: Oncotarget. 2017 Sep 15;8(44):77915-77927.
Title: Effect of TALEN-mediated IL-6 knockout on cell proliferation, apoptosis, invasion and anti-cancer therapy in hepatocellular carcinoma (HCC-LM3) cells.
Author: Zhuang, Peng-Yuan|Zhang, Ke-Wei|Wang, Jian-Dong|Zhou, Xue-Ping|Liu, Ying-Bin|Quan, Zhi-Wei|Shen, Jun
PMID: 29100435
Journal: Cancer Res. 2017 Nov 1;77(21):5831-5845.
Title: ANGPTL1 Interacts with Integrin alpha1beta1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling.
Author: Yan, Qian|Jiang, Lingxi|Liu, Ming|Yu, Dandan|Zhang, Yu|Li, Yan|Fang, Shuo|Li, Yan|Zhu, Ying-Hui|Yuan, Yun-Fei|Guan, Xin-Yuan
PMID: 28904065
Journal: FASEB J. 2017 Dec;31(12):5530-5542.
Title: Gab2 mediates hepatocellular carcinogenesis by integrating multiple signaling pathways.
Author: Cheng, Jianghong|Zhong, Yanhong|Chen, Shuai|Sun, Yan|Huang, Lantang|Kang, Yujia|Chen, Baozhen|Chen, Gang|Wang, Fengli|Tian, Yingpu|Liu, Wenjie|Feng, Gen-Sheng|Lu, Zhongxian
PMID: 28842424
Journal: Oncol Rep. 2017 Aug;38(2):1224-1232.
Title: Norcantharidin inhibits IL-6-induced epithelialmesenchymal transition via the JAK2/STAT3/TWIST signaling pathway in hepatocellular carcinoma cells.
Author: Gao, Yebo|Li, Weidong|Liu, Rui|Guo, Qiujun|Li, Jie|Bao, Yanju|Zheng, Honggang|Jiang, Shulong|Hua, Baojin
PMID: 28677802
Journal: Int J Biol Macromol. 2017 Nov;104(Pt A):681-686.
Title: A pumpkin polysaccharide induces apoptosis by inhibiting the JAK2/STAT3 pathway in human hepatoma HepG2 cells.
Author: Shen, Weixi|Chen, Chunhong|Guan, Yuanyuan|Song, Xiaowei|Jin, Yinghua|Wang, Jingfang|Hu, Yu|Xin, Tao|Jiang, Qiuying|Zhong, Li
PMID: 28634059
Journal: Oncol Lett. 2017 Feb;13(2):770-776.
Title: Autophagy impacts on oxaliplatin-induced hepatocarcinoma apoptosis via the IL-17/IL-17R-JAK2/STAT3 signaling pathway.
Author: Wu, Jinghua|Guo, Jiapei|Cao, Qing|Wang, Yi|Chen, Junmao|Wang, Zhigang|Yuan, Zhiyong
PMID: 28356957
Journal: Int J Oncol. 2017 May;50(5):1647-1654.
Title: Clinical implication of Frizzled 2 expression and its association with epithelial-to-mesenchymal transition in hepatocellular carcinoma.
Author: Asano, Tomonari|Yamada, Suguru|Fuchs, Bryan C|Takami, Hideki|Hayashi, Masamichi|Sugimoto, Hiroyuki|Fujii, Tsutomu|Tanabe, Kenneth K|Kodera, Yasuhiro
PMID: 28350091
Journal: J Cancer Res Clin Oncol. 2017 May;143(5):821-834.
Title: Hepatic inflammation-fibrosis-cancer axis in the rat hepatocellular carcinoma induced by diethylnitrosamine.
Author: Ding, Yong-Fang|Wu, Zhen-Hui|Wei, Ying-Jie|Shu, Luan|Peng, Yun-Ru
PMID: 28238064
Journal: BMC Complement Altern Med. 2017 Feb 10;17(1):106.
Title: Cryptotanshinone enhances the effect of Arsenic trioxide in treating liver cancer cell by inducing apoptosis through downregulating phosphorylated- STAT3 in vitro and in vivo.
Author: Shen, Li|Zhang, Guangshun|Lou, Zhaohuan|Xu, Guanhua|Zhang, Guangji
PMID: 28187727
Journal: J Biol Chem. 2017 Mar 3;292(9):3789-3799.
Title: Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice.
Author: Shi, Sally Yu|Luk, Cynthia T|Schroer, Stephanie A|Kim, Min Jeong|Dodington, David W|Sivasubramaniyam, Tharini|Lin, Lauren|Cai, Erica P|Lu, Shun-Yan|Wagner, Kay-Uwe|Bazinet, Richard P|Woo, Minna
PMID: 28100771
Journal: Oncol Res. 2017 Jan 26;25(2):285-293.
Title: CKLF-Like MARVEL Transmembrane Domain-Containing Member 3 (CMTM3) Inhibits the Proliferation and Tumorigenisis in Hepatocellular Carcinoma Cells.
Author: Li, Wujun|Zhang, Shaobo
PMID: 27629543
Journal: Eur Rev Med Pharmacol Sci. 2017 Mar;21(6):1248-1253.
Title: Facilitation of liver cancer SMCC7721 cell aging by sirtuin 4 via inhibiting JAK2/STAT3 signal pathway.
Author: Xia, X-H|Xiao, C-J|Shan, H
PMID: 28387906
Journal: Immunol Cell Biol. 2018 Oct 9.
Title: Hsa_circ_101280 promotes hepatocellular carcinoma by regulating miR-375/JAK2.
Author: Cao, Shuang|Wang, Guohua|Wang, Jia|Li, Cheng|Zhang, Le
PMID: 30302825
Journal: Cancer Sci. 2018 Sep 27.
Title: Mechanism and prognostic value of indoleamine 2,3-dioxygenase 1 expressed in hepatocellular carcinoma.
Author: Li, Shaolong|Han, Xue|Lyu, Ning|Xie, Qiankun|Deng, Haijing|Mu, Luwen|Pan, Tao|Huang, Xin|Wang, Xia|Shi, Yuanyuan|Zhao, Ming
PMID: 30264546
Journal: Cells. 2018 Aug 8;7(8). pii: cells7080099.
Title: CEP55 Promotes Cell Motility via JAK2(-)STAT3(-)MMPs Cascade in Hepatocellular Carcinoma.
Author: Li, Minjing|Gao, Ju|Li, Defang|Yin, Yancun
PMID: 30096813
Journal: Biomed Pharmacother. 2018 Nov;107:243-253.
Title: Amentoflavone suppresses hepatocellular carcinoma by repressing hexokinase 2 expression through inhibiting JAK2/STAT3 signaling.
Author: Liu, Bo|Yu, Shuo
PMID: 30096628
Journal: Biochimie. 2018 Sep;152:43-52.
Title: A new xanthatin analogue 1beta-hydroxyl-5alpha-chloro-8-epi-xanthatin induces apoptosis through ROS-mediated ERK/p38 MAPK activation and JAK2/STAT3 inhibition in human hepatocellular carcinoma.
Author: Fang, Xin-Yi|Zhang, Hai|Zhao, Lin|Tan, Shuai|Ren, Qing-Cuo|Wang, Lun|Shen, Xiao-Fei
PMID: 29960031
Journal: Biomed Pharmacother. 2018 Oct;106:134-141.
Title: Long non-coding RNA FEZF1-AS1 promotes cell invasion and epithelial-mesenchymal transition through JAK2/STAT3 signaling pathway in human hepatocellular carcinoma.
Author: Wang, Ya-Dong|Sun, Xue-Jun|Yin, Jia-Jun|Yin, Min|Wang, Wei|Nie, Zhe-Qun|Xu, Jian
PMID: 29957463
Journal: Int J Biochem Cell Biol. 2018 Aug;101:19-28.
Title: LncRNA TUG1 interacting with miR-144 contributes to proliferation, migration and tumorigenesis through activating the JAK2/STAT3 pathway in hepatocellular carcinoma.
Author: Lv, Jun|Kong, Yongkui|Gao, Zhiqiang|Liu, Yanmin|Zhu, Pengfei|Yu, Zujiang
PMID: 29791864
Journal: J Exp Pharmacol. 2018 May 9;10:9-17.
Title: Pilot study of the antifibrotic effects of the multikinase inhibitor pacritinib in a mouse model of liver fibrosis.
Author: Al-Fayoumi, Suliman|Hashiguchi, Taishi|Shirakata, Yuka|Mascarenhas, John|Singer, Jack W
PMID: 29785143
Journal: Am J Cancer Res. 2018 Apr 1;8(4):662-674. eCollection 2018.
Title: miR-337-3p suppresses the proliferation and invasion of hepatocellular carcinoma cells through targeting JAK2.
Author: Zuo, Xue-Liang|Chen, Zhi-Qiang|Wang, Jun-Feng|Wang, Jin-Guo|Liang, Lin-Hu|Cai, Juan
PMID: 29736311
Journal: J Cell Mol Med. 2018 Jul;22(7):3679-3690.
Title: The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway.
Author: Zhang, Ketao|Che, Siyao|Pan, Chuzhi|Su, Zheng|Zheng, Shangyou|Yang, Shanglin|Zhang, Huayao|Li, Wenda|Wang, Weidong|Liu, Jianping
PMID: 29722127
Journal: Sci Rep. 2018 Apr 12;8(1):5932.
Title: Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals.
Author: Singh, Ashok K|Bhadauria, Archana S|Kumar, Umesh|Raj, Vinit|Rai, Amit|Kumar, Pranesh|Keshari, Amit K|Kumar, Dinesh|Maity, Biswanath|Nath, Sneha|Prakash, Anand|Saha, Sudipta
PMID: 29651140
Journal: Life Sci. 2018 May 15;201:161-172.
Title: Novel fused oxazepino-indoles (FOIs) attenuate liver carcinogenesis via IL-6/JAK2/STAT3 signaling blockade as evidenced through data-based mathematical modeling.
Author: Singh, Ashok K|Bhadauria, Archana Singh|Kumar, Umesh|Raj, Vinit|Maurya, Vimal|Kumar, Dinesh|Maity, Biswanath|Prakash, Anand|De, Arnab|Samanta, Amalesh|Saha, Sudipta
PMID: 29486150
Journal: Oncol Rep. 2018 Apr;39(4):1883-1891.
Title: Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL-6-stimulated liver cancer cells.
Author: Kim, Buyun|Park, Byoungduck
PMID: 29393468
Journal: Biomed Pharmacother. 2018 Feb;98:214-221.
Title: STAT3 aggravates TGF-beta1-induced hepatic epithelial-to-mesenchymal transition and migration.
Author: Wang, Bin|Liu, Ting|Wu, Jun-Cheng|Luo, Sheng-Zheng|Chen, Rong|Lu, Lun-Gen|Xu, Ming-Yi
PMID: 29268242
Journal: Neoplasia. 2018 Jan;20(1):57-68.
Title: Stimulation of Interferon-Stimulated Gene 20 by Thyroid Hormone Enhances Angiogenesis in Liver Cancer.
Author: Lin, Syuan-Ling|Wu, Sheng-Ming|Chung, I-Hsiao|Lin, Yang-Hsiang|Chen, Ching-Ying|Chi, Hsiang-Cheng|Lin, Tzu-Kang|Yeh, Chau-Ting|Lin, Kwang-Huei
PMID: 29195126