Primary Site >> Liver Cancer

Gene >> IL2

Journal: Cancer Res. 1986 Nov;46(11):5667-70.
Title: Induction of lymphokine-activated killer cells in strain 2 guinea pigs with human interleukin-2.
Author: Zwilling, B S|Aldrich, W A|Rinehart, J J
PMID: 3489527
Journal: Cancer. 1986 Sep 1;58(5):1001-6.
Title: Treatment for unresectable hepatoma via selective hepatic arterial infusion of lymphokine-activated killer cells generated from autologous spleen cells.
Author: Okuno, K|Takagi, H|Nakamura, T|Nakamura, Y|Iwasa, Z|Yasutomi, M
PMID: 2425926
Journal: Asian Pac J Allergy Immunol. 1987 Jun;5(1):13-6.
Title: Interleukin 2 and lymphokine-activated killer cells in the treatment of childhood primary hepatocellular carcinoma--a preliminary report.
Author: Hsieh, K H|Chang, J S|Wu, H L|Chu, C T
PMID: 3040030
Journal: Cancer Immunol Immunother. 1988;27(3):278-82.
Title: Long-term influence of adjuvant therapy on natural killer cell activity in breast cancer.
Author: Tichatschek, E|Zielinski, C C|Muller, C|Sevelda, P|Kubista, E|Czerwenka, K|Spona, J|Wolf, H|Eibl, M M
PMID: 2460239
Journal: J Cancer Res Clin Oncol. 1988;114(3):283-90.
Title: Immunotherapy of hepatocellular carcinoma with autologous lymphokine-activated killer cells and/or recombinant interleukin-2.
Author: Ishikawa, T|Imawari, M|Moriyama, T|Ohnishi, S|Matsuhashi, N|Suzuki, G|Takaku, F
PMID: 2838488
Journal: Cancer Res. 1988 Mar 1;48(5):1173-9.
Title: Combined therapy of mice bearing a lymphokine-activated killer-resistant tumor with recombinant interleukin 2 and an antitumor monoclonal antibody capable of inducing antibody-dependent cellular cytotoxicity.
Author: Kawase, I|Komuta, K|Hara, H|Inoue, T|Hosoe, S|Ikeda, T|Shirasaka, T|Yokota, S|Tanio, Y|Masuno, T
PMID: 3257715
Journal: Gan To Kagaku Ryoho. 1989 Apr;16(4 Pt 2-2):1455-61.
Title: [Experimental and clinical study of adoptive immunotherapy combined with preadministration of OK-432: a method to augment the therapeutic effect].
Author: Kan, N|Okino, T|Nakanishi, M|Sato, K|Mise, K|Teramura, Y|Yamasaki, S|Hori, T|Ohgaki, K|Tobe, T
PMID: 2786379
Journal: Cancer. 1989 Dec 1;64(11):2238-42.
Title: Lymphokine-activated killer cell induction in tumor-infiltrating leukocytes from colon cancer patients.
Author: Staren, E D|Economou, S G|Harris, J E|Braun, D P
PMID: 2804913
Journal: Hepatology. 1989 Aug;10(2):221-7.
Title: Lymphokine-activated killer cell activity in patients with primary and metastatic malignant liver tumors.
Author: Schwarz, R E|Iwatsuki, S|Herberman, R B|Whiteside, T L
PMID: 2787271
Journal: Cancer Immunol Immunother. 1989;30(5):312-6.
Title: Unimpaired ability to generate adherent lymphokine-activated killer (A-LAK) cells in patients with primary or metastatic liver tumors.
Author: Schwarz, R E|Iwatsuki, S|Herberman, R B|Whiteside, T L
PMID: 2624925
Journal: Hepatogastroenterology. 1989 Oct;36(5):352-6.
Title: Intratumoral echo-guided injection of interleukin-2 and lymphokine-activated killer cells in hepatocellular carcinoma.
Author: Gandolfi, L|Solmi, L|Pizza, G C|Bertoni, F|Muratori, R|De Vinci, C|Bacchini, P|Morelli, M C|Corrado, G
PMID: 2559885
Journal: Am J Gastroenterol. 1989 Apr;84(4):396-9.
Title: Circulating LAK-1 cells and autologous mixed lymphocyte reaction in patients with hepatocellular carcinoma.
Author: Stefanini, G F|Mazzetti, M|Zamorano, M A|Capelli, S|Castelli, E|Degli Esposti, P|Moretta, L|Gasbarrini, G
PMID: 2539011
Journal: Hepatology. 1989 Mar;9(3):471-6.
Title: Defective function of lymphokine-activated killer cells and natural killer cells in patients with hepatocellular carcinoma.
Author: Saibara, T|Onishi, S|Sakaeda, H|Yamamoto, Y
PMID: 2537790
Journal: Cancer Treat Rev. 1989 Jun;16 Suppl A:151-60.
Title: Adoptive immunotherapy administered via the hepatic artery and intralesional interleukin-2 in hepatocellular carcinoma.
Author: Fagan, E A|Pulley, M|Limb, A|Wolstencroft, R|Cranenburgh, C|De Vinci, C|Karani, J|Michell, M|Nunnerley, H|Zaman, S
PMID: 2475251
Journal: J Gastroenterol Hepatol. 1990 Sep-Oct;5(5):542-8.
Title: Defective immunological functions associated with abnormal lymphokine-activated killer activity in patients with hepatocellular carcinoma.
Author: Shirai, M|Watanabe, S|Nishioka, M
PMID: 1966592
Journal: Cancer. 1990 Sep 1;66(5):923-9.
Title: Functional and phenotypic characteristics of recombinant interleukin-2 or T-cell growth factor-activated splenic lymphoid cells from patients with gastric or hepatocellular carcinoma.
Author: Ebihara, T|Fukao, K|Koyama, S
PMID: 2167147
Journal: Eur J Cancer. 1990;26(10):1045-8.
Title: Antitumour effect of intratumoral injection of human recombinant interleukin-2 in patients with hepatocellular carcinoma: a preliminary report.
Author: Shirai, M|Watanabe, S|Nishioka, M
PMID: 2177345
Journal: Nihon Geka Gakkai Zasshi. 1991 Sep;92(9):1334-7.
Title: [Significance of reduction surgery for stage IV hepatocellular carcinoma (HCC) and postoperative immunochemotherapy for extension of survival period].
Author: Yamamoto, M|Iizuka, H|Kono, T|Inoue, S|Miura, K|Fujii, H|Matsuda, M
PMID: 1658592
Journal: Nihon Geka Gakkai Zasshi. 1991 Sep;92(9):1234-6.
Title: [LAK cell adoptive immunotherapy and its problems].
Author: Yamaguchi, Y|Takayama, T|Kawami, H|Sato, Y|Baba, N|Kuroi, K|Toge, T
PMID: 1944194
Journal: Zhonghua Zhong Liu Za Zhi. 1991 Mar;13(2):145-8.
Title: [Treatment of advanced liver cancer by autologous and/or homologous LAK cells combined with human natural LL-2].
Author: Han, F G
PMID: 1879294
Journal: Biotherapy. 1991;3(3):203-9.
Title: Augmentation of antitumor effect on syngeneic murine solid tumors by an interleukin 2 slow delivery system, the IL-2 mini-pellet.
Author: Fujiwara, T|Sakagami, K|Matsuoka, J|Shiozaki, S|Fujioka, K|Takada, Y|Uchida, S|Onoda, T|Orita, K
PMID: 1854589
Journal: In Vivo. 1991 Nov-Dec;5(6):561-5.
Title: Effective immunotherapy with local low doses of interleukin-2.
Author: Den Otter, W|Maas, R A|Koten, J W|Dullens, H F|Bernsen, M|Klein, W R|Rutten, V P|Steerenberg, P A|Balemans, L|Ruitenberg, E J
PMID: 1810439
Journal: Am J Nephrol. 1991;11(6):493-6.
Title: Crescentic IgA glomerulonephritis following interleukin-2 therapy for hepatocellular carcinoma of the liver.
Author: Chan, T M|Cheng, I K|Wong, K L|Chan, K W|Lai, C L
PMID: 1668057
Journal: J Gastroenterol Hepatol. 1992 Mar-Apr;7(2):136-41.
Title: Induction of allogeneic tumour- and lymphokine-activated lymphocytes against hepatocellular carcinoma.
Author: Yasumura, S|Higuchi, K|Hioki, O|Okada, K|Tsukishiro, T|Tsuchida, T|Miyagiwa, M|Nambu, S|Yasuyama, T|Inoue, K
PMID: 1315167
Journal: J Biol Regul Homeost Agents. 1993 Oct-Dec;7(4):121-5.
Title: Cancer immunotherapy with low-dose interleukin-2 subcutaneous administration: potential efficacy in most solid tumor histotypes by a concomitant treatment with the pineal hormone melatonin.
Author: Lissoni, P|Barni, S|Ardizzoia, A|Olivini, G|Brivio, F|Tisi, E|Tancini, G|Characiejus, D|Kothari, L
PMID: 8023699
Journal: Semin Surg Oncol. 1993 Jul-Aug;9(4):332-6.
Title: Postoperative chemoimmunotherapy for the treatment of liver cancer.
Author: Uchino, J|Une, Y|Kawata, A|Wakisaka, Y|Hosokawa, M
PMID: 8210915
Journal: J Gastroenterol Hepatol. 1993 Nov-Dec;8(6):517-23.
Title: Immunological responses against an autologous human hepatocellular carcinoma cell line.
Author: Usuda, S|Yoshizawa, K|Yabu, K|Kiyosawa, K
PMID: 8280838
Journal: Cancer. 1993 Jun 1;71(11):3633-9.
Title: Short-duration in vitro interleukin-2-activated mononuclear cells for advanced cancer. A Hong Kong biotherapy pilot study trial.
Author: Yeung, A W|Pang, Y K|Tsang, Y C|Wong, S W|Leung, J S
PMID: 8387882
Journal: Cancer Immunol Immunother. 1993;36(3):141-8.
Title: Interleukin-2 in cancer treatment: disappointing or (still) promising? A review.
Author: Maas, R A|Dullens, H F|Den Otter, W
PMID: 8439974
Journal: Gan To Kagaku Ryoho. 1994 Sep;21(13):2115-7.
Title: [Induction of anti-cancer cells and systemic immune response in hepatocellular carcinoma by OK-432].
Author: Aramaki, M|Nakashima, K|Sasaki, A|Shimoda, K|Yoshida, T|Kim, Y I|Kitano, S|Kobayashi, M
PMID: 7944416
Journal: Hepatogastroenterology. 1994 Aug;41(4):363-6.
Title: Induction by OK-432 of lymphokine activated killer precursor cells in hepatocellular carcinoma.
Author: Aramaki, M|Kim, Y I|Shimoda, K|Nakashima, K|Okada, K|Kobayashi, M
PMID: 7959572
Journal: Cancer Res. 1994 Jul 15;54(14):3808-16.
Title: Immunotherapy of liver metastases of human gastric carcinoma with interleukin 2-activated natural killer cells.
Author: Yasumura, S|Lin, W C|Hirabayashi, H|Vujanovic, N L|Herberman, R B|Whiteside, T L
PMID: 8033100
Journal: Cancer Gene Ther. 1995 Sep;2(3):183-90.
Title: Interleukin-2-secreting mouse fibroblasts transfected with genomic DNA from murine neoplasms induce tumor-specific immune responses that prolong the lives of tumor-bearing mice.
Author: Sun, T|Kim, T S|Waltz, M R|Cohen, E P
PMID: 8528961
Journal: Oncol Rep. 1995 Nov;2(6):1063-8.
Title: Efficacy and tolerability of cancer neuroimmunotherapy with subcutaneous low-dose interleukin-2 and the pineal hormone melatonin - a progress report of 200 patients with advanced solid neoplasms.
Author: Lissoni, P|Ardizzoia, A|Barni, S|Brivio, F|Tisi, E|Rovelli, F|Tancini, G|Maestroni, G|Fumagalli, L
PMID: 21597854
Journal: J Immunother. 1997 Mar;20(2):158-63.
Title: Intralesional sonographically guided injections of lymphokine-activated killer cells and recombinant interleukin-2 for the treatment of liver tumors: a pilot study.
Author: Ferlazzo, G|Scisca, C|Iemmo, R|Cavaliere, R|Quartarone, G|Adamo, V|Frazzetto, G|Costa, G|Melioli, G
PMID: 9087388
Journal: Cancer Immunol Immunother. 1997 Oct;45(2):63-70.
Title: The tumor-bearing state induces augmented responses of organ-associated lymphocytes to high-dose interleukin-2 therapy in mice.
Author: Asano, Y|Kaneda, K|Hiragushi, J|Tsuchida, T|Higashino, K
PMID: 9390196
Journal: Hum Gene Ther. 1997 Dec 10;8(18):2173-82.
Title: In vivo therapy of hepatocellular carcinoma with a tumor-specific adenoviral vector expressing interleukin-2.
Author: Bui, L A|Butterfield, L H|Kim, J Y|Ribas, A|Seu, P|Lau, R|Glaspy, J A|McBride, W H|Economou, J S
PMID: 9449371
Journal: Leuk Lymphoma. 1997 Nov;27(5-6):459-67.
Title: Cytolytic activity of peripheral blood blast cells from patients with acute myeloid leukemia.
Author: Braun, D P|Preisler, H D
PMID: 9477127
Journal: Cancer Biother Radiopharm. 1997 Feb;12(1):37-45.
Title: Patterns of hepatic and splenic colonization by an attenuated strain of Salmonella typhimurium containing the gene for human interleukin-2: a novel anti-tumor agent.
Author: Saltzman, D A|Katsanis, E|Heise, C P|Hasz, D E|Kelly, S M|Curtiss, R 3rd|Leonard, A S|Anderson, P M
PMID: 10851445
Journal: Gan To Kagaku Ryoho. 1998 Jul;25(9):1397-401.
Title: [Clinical evaluation of intermittent hepatic arterial infusion therapy for metastatic liver tumor of gastric and colorectal cancer].
Author: Miya, K|Adachi, T|Nagao, N|Takagi, Y|Kawaguchi, Y|Kato, M|Takao, H|Sugiyama, Y|Kunieda, K|Umemoto, T|Fukada, D|Saji, S
PMID: 9703838
Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1998 Oct;20(5):334-8.
Title: [Retroviral-mediated transcriptional regulatory elements of alpha-fetoprotein gene directed specific expression of interleukin-2 in murine hepatoma].
Author: Ma, Q|Wu, Y|Yu, L|Zhang, Y
PMID: 11717988
Journal: Mol Med. 2001 Aug;7(8):561-8.
Title: Combination vascular delivery of herpes simplex oncolytic viruses and amplicon mediated cytokine gene transfer is effective therapy for experimental liver cancer.
Author: Zager, J S|Delman, K A|Malhotra, S|Ebright, M I|Bennett, J J|Kates, T|Halterman, M|Federoff, H|Fong, Y
PMID: 11591892
Journal: World J Gastroenterol. 2002 Apr;8(2):233-6.
Title: Effects of cryopreservation and phenylacetate on biological characters of adherent LAK cells from patients with hepatocellular carcinoma.
Author: Zheng, Ning|Ye, Sheng-Long|Sun, Rui-Xia|Zhao, Yan|Tang, Zhao-You
PMID: 11925598
Journal: Zhonghua Wai Ke Za Zhi. 2002 Feb;40(2):97-9.
Title: [Changes of immune function in liver cirrhosis patients after splenectomy combined with resection of hepatocellular carcinoma].
Author: Cao, Zhixin|Cheng, Xiaoping|Wu, Zaide
PMID: 11955389
Journal: World J Gastroenterol. 2002 Jun;8(3):464-8.
Title: Antitumor activities of human autologous cytokine-induced killer (CIK) cells against hepatocellular carcinoma cells in vitro and in vivo.
Author: Wang, Fu-Sheng|Liu, Ming-Xu|Zhang, Bing|Shi, Ming|Lei, Zhou-Yun|Sun, Wen-Bing|Du, Qing-You|Chen, Ju-Mei
PMID: 12046071
Journal: Hepatogastroenterology. 2002 Jul-Aug;49(46):1109-12.
Title: Locoregional immunochemotherapy in hepatocellular carcinoma.
Author: Kountouras, J|Boura, P|Kouklakis, G
PMID: 12143214
Journal: Zhonghua Gan Zang Bing Za Zhi. 2002 Dec;10(6):417-20.
Title: [Immunoprotective effect of IL-2 and B7-1 gene co-transfected liver cancer vaccines on hepatocarcinogenesis in mice].
Author: Ge, Ningling|Ye, Shenglong|Liu, Yinkun|Tang, Zhaoyou
PMID: 12502440
Journal: World J Gastroenterol. 2003 Nov;9(11):2460-3.
Title: Effects of splenectomy in patients with cirrhosis undergoing hepatic resection for hepatocellular carcinoma.
Author: Cao, Zhi-Xin|Chen, Xiao-Ping|Wu, Zai-De
PMID: 14606076
Journal: World J Gastroenterol. 2003 Oct;9(10):2182-5.
Title: Prevention of hepatocellular carcinoma in mice by IL-2 and B7-1 genes co-transfected liver cancer cell vaccines.
Author: Ge, Ning-Ling|Ye, Sheng-Long|Zheng, Ning|Sun, Rui-Xia|Liu, Yin-Kun|Tang, Zhao-You
PMID: 14562374
Journal: Gastroenterology. 2005 Dec;129(6):2064-75.
Title: Liver gene expression signature of mild fibrosis in patients with chronic hepatitis C.
Author: Asselah, Tarik|Bieche, Ivan|Laurendeau, Ingrid|Paradis, Valerie|Vidaud, Dominique|Degott, Claude|Martinot, Michelle|Bedossa, Pierre|Valla, Dominique|Vidaud, Michel|Marcellin, Patrick
PMID: 16344072
Journal: Transpl Int. 2007 May;20(5):467-70.
Title: Treatment of antibody-mediated rejection with high-dose immunoglobulins in ABO-incompatible liver transplant recipient.
Author: Urbani, Lucio|Mazzoni, Alessandro|De Simone, Paolo|Catalano, Gabriele|Coletti, Laura|Montin, Umberto|Morelli, Luca|Campani, Daniela|Pollina, Luca|Biancofiore, Gianni|Bindi, Lucia|Scatena, Fabrizio|Filipponi, Franco
PMID: 17263788
Journal: J Viral Hepat. 2010 Oct;17(10):705-13.
Title: Generation of cellular immune responses to HCV NS5 protein through in vivo activation of dendritic cells.
Author: Wintermeyer, P|Gehring, S|Eken, A|Wands, J R
PMID: 20002303
Journal: Mol Med Rep. 2011 Nov-Dec;4(6):1067-73.
Title: A new membrane re-anchored protein originating from GPC3 against hepatoma cells HepG2.
Author: Yang, Dongye|Yang, Junwen|Lu, Fanggen|Li, Caihong|Yang, Jingbo|Liang, Jieling
PMID: 21904776
Journal: Cancer Immunol Immunother. 2013 Apr;62(4):737-46.
Title: Immune modulation of effector CD4+ and regulatory T cell function by sorafenib in patients with hepatocellular carcinoma.
Author: Cabrera, Roniel|Ararat, Miguel|Xu, Yiling|Brusko, Todd|Wasserfall, Clive|Atkinson, Mark A|Chang, Lung Ji|Liu, Chen|Nelson, David R
PMID: 23223899
Journal: Cytotherapy. 2014 Aug;16(8):1121-31.
Title: T cells redirected to interleukin-13Ralpha2 with interleukin-13 mutein--chimeric antigen receptors have anti-glioma activity but also recognize interleukin-13Ralpha1.
Author: Krebs, Simone|Chow, Kevin K H|Yi, Zhongzhen|Rodriguez-Cruz, Tania|Hegde, Meenakshi|Gerken, Claudia|Ahmed, Nabil|Gottschalk, Stephen
PMID: 24841514
Journal: Mol Med Rep. 2014 Oct;10(4):2153-9.
Title: Kanglaite stimulates anticancer immune responses and inhibits HepG2 cell transplantationinduced tumor growth.
Author: Huang, Xinli|Qin, Jianjie|Lu, Sen
PMID: 25119060
Journal: Food Chem Toxicol. 2015 Apr;78:64-70.
Title: Identification and functional characterization of a novel fungal immunomodulatory protein from Postia placenta.
Author: Li, Shu Ying|Shi, Li Jun|Ding, Yang|Nie, Ying|Tang, Xuan Ming
PMID: 25662032
Journal: Med Sci Monit Basic Res. 2015 Apr 27;21:81-5.
Title: Characterization of solid tumors induced by polycyclic aromatic hydrocarbons in mice.
Author: Wang, Qiulan|Xue, Yongjie
PMID: 25913077
Journal: Cancer Immunol Res. 2016 Jul;4(7):574-81.
Title: Expanded and Activated Natural Killer Cells for Immunotherapy of Hepatocellular Carcinoma.
Author: Kamiya, Takahiro|Chang, Yu-Hsiang|Campana, Dario
PMID: 27197065
Journal: PLoS One. 2016 Oct 13;11(10):e0164723.
Title: Identification of Optimal Insertion Site in Recombinant Newcastle Disease Virus (rNDV) Vector Expressing Foreign Gene to Enhance Its Anti-Tumor Effect.
Author: Pan, Ziye|He, Jinjiao|Rasoul, Lubna M|Liu, Yunye|Che, Ruixiang|Ding, Yun|Guo, Xiaocheng|Yang, Jiarui|Zou, Dehua|Zhang, Hua|Li, Deshan|Cao, Hongwei
PMID: 27736965
Journal: Clin Cancer Res. 2017 May 15;23(10):2478-2490.
Title: Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting.
Author: Slaney, Clare Y|von Scheidt, Bianca|Davenport, Alexander J|Beavis, Paul A|Westwood, Jennifer A|Mardiana, Sherly|Tscharke, David C|Ellis, Sarah|Prince, H Miles|Trapani, Joseph A|Johnstone, Ricky W|Smyth, Mark J|Teng, Michele W|Ali, Aesha|Yu, Zhiya|Rosenber
PMID: 27965307
Journal: Cancer Immunol Res. 2017 Jun;5(6):493-502.
Title: Tumor-Derived alpha-Fetoprotein Directly Drives Human Natural Killer-Cell Activation and Subsequent Cell Death.
Author: Vujanovic, Lazar|Stahl, Elizabeth C|Pardee, Angela D|Geller, David A|Tsung, Allan|Watkins, Simon C|Gibson, Gregory A|Storkus, Walter J|Butterfield, Lisa H
PMID: 28468916
Journal: J Virol Methods. 2017 Oct;248:195-201.
Title: CpG oligonucleotides increase HBV-specific cytokine responses in whole blood and enhance cytokine release assay sensitivity.
Author: Dammermann, Werner|Dornbrack, Julia|Broker, Katharina|Bentzien, Frank|Luth, Stefan
PMID: 28739303
Journal: Mol Med Rep. 2018 Jan;17(1):300-306.
Title: Genetically engineered recombinant adenovirus expressing interleukin2 for hepatocellular carcinoma therapy.
Author: Sun, Yunpeng|Wu, Huanhuan|Chen, Gang|Huang, Xiaming|Shan, Yunfeng|Shi, Hongqi|Zhang, Qiyu|Zheng, Yihu
PMID: 29115604