Literatures

Primary Site >> Colorectal Cancer

Gene >> IGF1R

1.
Journal:	Ann N Y Acad Sci. 2002 Nov;973:555-8.
Title:	Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-l-cysteine.
Author:	Kelly, Raymond G\|Nally, Kenneth\|Shanahan, Fergus\|O'Connell, Joe
PMID:	12485928

2.
Journal:	Orv Hetil. 2006 Sep 24;147(38):1835-41.
Title:	[Insulin-like growth factor receptor, hepatocyte-derived growth factor receptor and telomerase expression in ulcerative colitis].
Author:	Sipos, Ferenc\|Molnar, Bela\|Zagoni, Tamas\|Miheller, Pal\|Tulassay, Zsolt
PMID:	17066600

3.
Journal:	Br J Cancer. 2008 Jul 8;99(1):83-9.
Title:	Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients.
Author:	Cappuzzo, F\|Varella-Garcia, M\|Finocchiaro, G\|Skokan, M\|Gajapathy, S\|Carnaghi, C\|Rimassa, L\|Rossi, E\|Ligorio, C\|Di Tommaso, L\|Holmes, A J\|Toschi, L\|Tallini, G\|Destro, A\|Roncalli, M\|Santoro, A\|Janne, P A
PMID:	18577988

4.
Journal:	Oncol Rep. 2008 Aug;20(2):359-64.
Title:	Clinicopathological significance of the gene expression of matrix metalloproteinase-7, insulin-like growth factor-1, insulin-like growth factor-2 and insulin-like growth factor-1 receptor in patients with colorectal cancer: insulin-like growth factor-1 re
Author:	Oshima, Takashi\|Akaike, Makoto\|Yoshihara, Kazue\|Shiozawa, Manabu\|Yamamoto, Naoto\|Sato, Tsutomu\|Yamada, Roppei\|Fujii, Shoich\|Rino, Yasushi\|Kunisaki, Chikara\|Tanaka, Katsuaki\|Masuda, Munetaka\|Imada, Toshio
PMID:	18636198

5.
Journal:	Cancer Res. 2008 Oct 1;68(19):8004-13.
Title:	Heterogeneity of receptor function in colon carcinoma cells determined by cross-talk between type I insulin-like growth factor receptor and epidermal growth factor receptor.
Author:	Hu, Yi Peter\|Patil, Sandip B\|Panasiewicz, Michelle\|Li, Wenhui\|Hauser, Jennie\|Humphrey, Lisa E\|Brattain, Michael G
PMID:	18829558

6.
Journal:	Scand J Gastroenterol. 2008 Mar;43(3):289-98.
Title:	Elevated insulin-like growth factor 1 receptor, hepatocyte growth factor receptor and telomerase protein expression in mild ulcerative colitis.
Author:	Sipos, Ferenc\|Galamb, Orsolya\|Herszenyi, Laszlo\|Molnar, Bela\|Solymosi, Norbert\|Zagoni, Tamas\|Berczi, Lajos\|Tulassay, Zsolt
PMID:	18938767

7.
Journal:	Gastrointest Cancer Res. 2008 Jul;2(4 Suppl):S20-2.
Title:	Colorectal Cancer Treatment: What's Next? (or: Is There Life After EGFR and VEGF?).
Author:	Saltz, Leonard
PMID:	19343143

8.
Journal:	Gene Regul Syst Bio. 2008 May 2;2:163-176.
Title:	Multi-Target Approaches in Colon Cancer Chemoprevention Based on Systems Biology of Tumor Cell-Signaling.
Author:	Guruswamy, Suresh\|Rao, Chinthalapally V
PMID:	19763245

9.
Journal:	Arch Med Res. 2009 May;40(4):235-40.
Title:	Knockdown of IGF-IR by RNAi inhibits SW480 colon cancer cells growth in vitro.
Author:	Yavari, Kamal\|Taghikhani, Mohammad\|Maragheh, Mohammad Ghannadi\|Mesbah-Namin, Seyed A\|Babaei, Mohammad Hosein
PMID:	19608011

10.
Journal:	J Biol Chem. 2009 Nov 13;284(46):32178-87.
Title:	Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.
Author:	Zhao, Ming\|Wan, Zhu-li\|Whittaker, Linda\|Xu, Bin\|Phillips, Nelson B\|Katsoyannis, Panayotis G\|Ismail-Beigi, Faramarz\|Whittaker, Jonathan\|Weiss, Michael A
PMID:	19773552

11.
Journal:	Nutr Cancer. 2009;61(4):544-53.
Title:	Curcumin synergizes with resveratrol to inhibit colon cancer.
Author:	Majumdar, Adhip P N\|Banerjee, Sanjeev\|Nautiyal, Jyoti\|Patel, Bhaumik B\|Patel, Vaishali\|Du, Jianhua\|Yu, Yingjie\|Elliott, Althea A\|Levi, Edi\|Sarkar, Fazlul H
PMID:	19838927

12.
Journal:	BMC Cancer. 2010 May 7;10:184.
Title:	Elevated IGFIR expression regulating VEGF and VEGF-C predicts lymph node metastasis in human colorectal cancer.
Author:	Zhang, Chunhui\|Hao, Li\|Wang, Liang\|Xiao, Yichuan\|Ge, Hailiang\|Zhu, Zhenya\|Luo, Yunbao\|Zhang, Yi\|Zhang, Yanyun
PMID:	20459642

13.
Journal:	BMC Cancer. 2010 May 26;10:238.
Title:	Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways.
Author:	Vanamala, Jairam\|Reddivari, Lavanya\|Radhakrishnan, Sridhar\|Tarver, Chris
PMID:	20504360

14.
Journal:	Clin Cancer Res. 2010 Jun 15;16(12):3193-204.
Title:	Development of an integrated genomic classifier for a novel agent in colorectal cancer: approach to individualized therapy in early development.
Author:	Pitts, Todd M\|Tan, Aik Choon\|Kulikowski, Gillian N\|Tentler, John J\|Brown, Amy M\|Flanigan, Sara A\|Leong, Stephen\|Coldren, Christopher D\|Hirsch, Fred R\|Varella-Garcia, Marileila\|Korch, Christopher\|Eckhardt, S Gail
PMID:	20530704

15.
Journal:	Curr Cancer Drug Targets. 2010 Dec;10(8):824-33.
Title:	Strategies for overcoming inherent and acquired resistance to EGFR inhibitors by targeting downstream effectors in the RAS/PI3K pathway.
Author:	Weickhardt, Andrew J\|Tebbutt, Niall C\|Mariadason, John M
PMID:	20718704

16.
Journal:	OMICS. 2010 Aug 20.
Title:	ChIP-seq and Functional Analysis of the SOX2 Gene in Colorectal Cancers.
Author:	Fang, Xuefeng\|Yu, Wei\|Li, Lisha\|Shao, Jiaofang\|Zhao, Na\|Chen, Qiyun\|Ye, Zhiyun\|Lin, Sheng-Cai\|Zheng, Shu\|Lin, Biaoyang
PMID:	20726776

17.
Journal:	OMICS. 2010 Aug;14(4):369-84.
Title:	ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers.
Author:	Fang, Xuefeng\|Yu, Wei\|Li, Lisha\|Shao, Jiaofang\|Zhao, Na\|Chen, Qiyun\|Ye, Zhiyun\|Lin, Sheng-Cai\|Zheng, Shu\|Lin, Biaoyang
PMID:	20726797

18.
Journal:	Clin Colorectal Cancer. 2010 Oct;9(4):219-23.
Title:	The insulin-like growth factor signaling pathway as a target for treatment of colorectal carcinoma.
Author:	Ewing, Gideon P\|Goff, Laura W
PMID:	20920993

19.
Journal:	Clin Cancer Res. 2010 Nov 15;16(22):5591-602.
Title:	Germline polymorphisms in genes involved in the IGF1 pathway predict efficacy of cetuximab in wild-type KRAS mCRC patients.
Author:	Winder, Thomas\|Zhang, Wu\|Yang, Dongyun\|Ning, Yan\|Bohanes, Pierre\|Gerger, Armin\|Wilson, Peter M\|Pohl, Alexandra\|Mauro, David J\|Langer, Christiane\|Rowinsky, Eric K\|Lenz, Heinz-Josef
PMID:	20935157

20.
Journal:	Anal Cell Pathol (Amst). 2010;33(5):229-44.
Title:	Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL.
Author:	Pennarun, Bodvael\|Kleibeuker, Jan H\|Oenema, Tjitske\|Stegehuis, Janet H\|de Vries, Elisabeth G E\|de Jong, Steven
PMID:	20978316

21.
Journal:	J Oncol. 2010;2010:135354.
Title:	Thrombopoietin receptor levels in tumor cell lines and primary tumors.
Author:	Erickson-Miller, Connie L\|Chadderton, Antony\|Gibbard, Anna\|Kirchner, Jennifer\|Pillarisetti, Kodandaram\|Baker, Katherine\|Pandite, Lini\|El-Hariry, Iman\|Mostafa Kamel, Yasser\|Liu, Yuan\|Martin, Anne-Marie\|Messam, Conrad
PMID:	21318160

22.
Journal:	Cancer Chemother Pharmacol. 2011 Oct;68(4):1045-55.
Title:	Analysis of KRAS, BRAF, PTEN, IGF1R, EGFR intron 1 CA status in both primary tumors and paired metastases in determining benefit from cetuximab therapy in colon cancer.
Author:	Park, Jin Hyun\|Han, Sae-Won\|Oh, Do-Youn\|Im, Seock-Ah\|Jeong, Seung-Yong\|Park, Kyu Joo\|Kim, Tae-You\|Bang, Yung-Jue\|Park, Jae-Gahb
PMID:	21340604

23.
Journal:	Clin Colorectal Cancer. 2011 Dec;10(4):325-32.
Title:	Is there a role for IGF1R and c-MET pathways in resistance to cetuximab in metastatic colorectal cancer?
Author:	Inno, Alessandro\|Di Salvatore, Mariantonietta\|Cenci, Tonia\|Martini, Maurizio\|Orlandi, Armando\|Strippoli, Antonia\|Ferrara, Anna Maria\|Bagala, Cinzia\|Cassano, Alessandra\|Larocca, Luigi Maria\|Barone, Carlo
PMID:	21729677

24.
Journal:	J Cancer. 2011;2:490-502. Epub 2011 Oct 1.
Title:	miRNA Alterations Modify Kinase Activation In The IGF-1 Pathway And Correlate With Colorectal Cancer Stage And Progression In Patients.
Author:	Knowlton, David L\|Tang, Kim\|Henstock, Peter V\|Subramanian, Romesh R
PMID:	21980324

25.
Journal:	Carcinogenesis. 2012 Mar;33(3):702-7.
Title:	Monosodium glutamate-induced diabetic mice are susceptible to azoxymethane-induced colon tumorigenesis.
Author:	Hata, Kazuya\|Kubota, Masaya\|Shimizu, Masahito\|Moriwaki, Hisataka\|Kuno, Toshiya\|Tanaka, Takuji\|Hara, Akira\|Hirose, Yoshinobu
PMID:	22223845

26.
Journal:	Int J Mol Sci. 2012;13(1):579-95.
Title:	Nutraceutical approach for preventing obesity-related colorectal and liver carcinogenesis.
Author:	Shimizu, Masahito\|Kubota, Masaya\|Tanaka, Takuji\|Moriwaki, Hisataka
PMID:	22312273

27.
Journal:	EMBO J. 2012 Apr 4;31(7):1752-63.
Title:	miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver.
Author:	Okamoto, Koji\|Ishiguro, Tatsuya\|Midorikawa, Yutaka\|Ohata, Hirokazu\|Izumiya, Masashi\|Tsuchiya, Naoto\|Sato, Ai\|Sakai, Hiroaki\|Nakagama, Hitoshi
PMID:	22373578

28.
Journal:	PLoS One. 2012;7(4):e36190.
Title:	The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer.
Author:	Esposito, Diana L\|Aru, Federica\|Lattanzio, Rossano\|Morgano, Annalisa\|Abbondanza, Michela\|Malekzadeh, Reza\|Bishehsari, Faraz\|Valanzano, Rosa\|Russo, Antonio\|Piantelli, Mauro\|Moschetta, Antonio\|Lotti, Lavinia Vittoria\|Mariani-Costantini, Renato
PMID:	22558377

29.
Journal:	Eur J Cancer. 2013 May;49(8):1799-807.
Title:	A dose finding, safety and pharmacokinetic study of AVE1642, an anti-insulin-like growth factor-1 receptor (IGF-1R/CD221) monoclonal antibody, administered as a single agent and in combination with docetaxel in patients with advanced solid tumours.
Author:	Soria, Jean Charles\|Massard, Christophe\|Lazar, Vladimir\|Ozoux, Marie-Laure\|Mery-Mignard, Dominique\|Deslandes, Antoine\|Tolcher, Anthony W
PMID:	23485230

30.
Journal:	Biochim Biophys Acta. 2013 Aug;1833(8):1924-35.
Title:	Curcumin affects proprotein convertase activity: elucidation of the molecular and subcellular mechanism.
Author:	Zhu, Jingjing\|Bultynck, Geert\|Luyten, Tomas\|Parys, Jan B\|Creemers, John W M\|Van de Ven, Wim J M\|Vermorken, Alphons J M
PMID:	23583304

31.
Journal:	J Cancer Res Clin Oncol. 2013 Jul;139(7):1241-50.
Title:	A pilot study comparing protein expression in different segments of the normal colon and rectum and in normal colon versus adenoma in patients with Lynch syndrome.
Author:	Wei, Chongjuan\|Chen, Jinyun\|Pande, Mala\|Lynch, Patrick M\|Frazier, Marsha L
PMID:	23604467

32.
Journal:	Nucl Med Biol. 2013 May;40(4):529-36.
Title:	Demonstration of dose dependent cytotoxic activity in SW480 colon cancer cells by (1)(7)(7)Lu-labeled siRNA targeting IGF-1R.
Author:	Fathi, Mojtaba\|Taghikhani, Mohammad\|Ghannadi-Maragheh, Mohammad\|Yavari, Kamal
PMID:	23618769

33.
Journal:	J Int Med Res. 2013 Aug;41(4):1228-35.
Title:	The role of insulin-like growth factor 1 and its receptor in the formation and development of colorectal carcinoma.
Author:	Zhang, Rong\|Xu, Guo-Liang\|Li, Yin\|He, Long-Jun\|Chen, Li-Ming\|Wang, Guo-Bao\|Lin, Shi-Yong\|Luo, Guang-Yu\|Gao, Xiao-Yan\|Shan, Hong-Bo
PMID:	23801064

34.
Journal:	Crit Rev Oncol Hematol. 2013 Nov;88(2):272-83.
Title:	Molecular biomarkers of resistance to anti-EGFR treatment in metastatic colorectal cancer, from classical to innovation.
Author:	Giampieri, Riccardo\|Scartozzi, Mario\|Del Prete, Michela\|Maccaroni, Elena\|Bittoni, Alessandro\|Faloppi, Luca\|Bianconi, Maristella\|Cecchini, Luca\|Cascinu, Stefano
PMID:	23806981

35.
Journal:	Clin Cancer Res. 2013 Nov 15;19(22):6219-29.
Title:	Overcoming IGF1R/IR resistance through inhibition of MEK signaling in colorectal cancer models.
Author:	Flanigan, Sara A\|Pitts, Todd M\|Newton, Timothy P\|Kulikowski, Gillian N\|Tan, Aik Choon\|McManus, Martine C\|Spreafico, Anna\|Kachaeva, Maria I\|Selby, Heather M\|Tentler, John J\|Eckhardt, S Gail\|Leong, Stephen
PMID:	24045180

36.
Journal:	Clin Colorectal Cancer. 2013 Dec;12(4):267-274.e2.
Title:	The prognostic role of ephrin A2 and endothelial growth factor receptor pathway mediators in patients with advanced colorectal cancer treated with cetuximab.
Author:	Strimpakos, Alexios\|Pentheroudakis, George\|Kotoula, Vassiliki\|De Roock, Wendy\|Kouvatseas, George\|Papakostas, Pavlos\|Makatsoris, Thomas\|Papamichael, Demetris\|Andreadou, Anna\|Sgouros, Joseph\|Zizi-Sermpetzoglou, Adamantia\|Kominea, Athina\|Televantou, Despina\|
PMID:	24050852

37.
Journal:	J Mol Signal. 2013 Oct 1;8(1):10.
Title:	Differential PKA activation and AKAP association determines cell fate in cancer cells.
Author:	Hedrick, Erik D\|Agarwal, Ekta\|Leiphrakpam, Premila D\|Haferbier, Katie L\|Brattain, Michael G\|Chowdhury, Sanjib
PMID:	24083380

38.
Journal:	Mol Cancer Ther. 2013 Dec;12(12):2929-39.
Title:	Molecular predictors of sensitivity to the insulin-like growth factor 1 receptor inhibitor Figitumumab (CP-751,871).
Author:	Pavlicek, Adam\|Lira, Maruja E\|Lee, Nathan V\|Ching, Keith A\|Ye, Jingjing\|Cao, Joan\|Garza, Scott J\|Hook, Kenneth E\|Ozeck, Mark\|Shi, Stephanie T\|Yuan, Jing\|Zheng, Xianxian\|Rejto, Paul A\|Kan, Julie L C\|Christensen, James G
PMID:	24107449

39.
Journal:	World J Gastroenterol. 2013 Nov 21;19(43):7788-94.
Title:	Insulin-like growth factor-1 induces lymphangiogenesis and facilitates lymphatic metastasis in colorectal cancer.
Author:	Li, Zhen-Jun\|Ying, Xiao-Jiang\|Chen, Hong-Liang\|Ye, Ping-Jiang\|Chen, Zhi-Liang\|Li, Gang\|Jiang, Hua-Feng\|Liu, Jiang\|Zhou, Shu-Zhen
PMID:	24282367

40.
Journal:	ISRN Hepatol. 2013 Apr 21;2013:206875.
Title:	Establishment and Validation of an Orthotopic Metastatic Mouse Model of Colorectal Cancer.
Author:	Rajput, Ashwani\|Agarwal, Ekta\|Leiphrakpam, Premila\|Brattain, Michael G\|Chowdhury, Sanjib
PMID:	27340651

41.
Journal:	Oncol Rep. 2014 Jan;31(1):87-94.
Title:	In vivo analysis of insulin-like growth factor type 1 receptor humanized monoclonal antibody MK-0646 and small molecule kinase inhibitor OSI-906 in colorectal cancer.
Author:	Leiphrakpam, Premila D\|Agarwal, Ekta\|Mathiesen, Michelle\|Haferbier, Katie L\|Brattain, Michael G\|Chowdhury, Sanjib
PMID:	24173770

42.
Journal:	Cancer Causes Control. 2014 Feb;25(2):161-70.
Title:	Racial differences in the association of insulin-like growth factor pathway and colorectal adenoma risk.
Author:	Ochs-Balcom, Heather M\|Vaughn, Caila B\|Nie, Jing\|Chen, Zhengyi\|Thompson, Cheryl L\|Parekh, Niyati\|Tracy, Russell\|Li, Li
PMID:	24194259

43.
Journal:	Cell Death Differ. 2014 Apr;21(4):568-81.
Title:	Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation.
Author:	Dai, W\|Bai, Y\|Hebda, L\|Zhong, X\|Liu, J\|Kao, J\|Duan, C
PMID:	24336047

44.
Journal:	Eur J Cancer. 2014 Apr;50(6):1207-21.
Title:	Clinical and biological significance of miR-378a-3p and miR-378a-5p in colorectal cancer.
Author:	Li, Hui\|Dai, Sujuan\|Zhen, Tiantian\|Shi, Huijuan\|Zhang, Fenfen\|Yang, Yang\|Kang, Lili\|Liang, Yingjie\|Han, Anjia
PMID:	24412052

45.
Journal:	Cell Signal. 2014 May;26(5):868-79.
Title:	Ezrin expression and cell survival regulation in colorectal cancer.
Author:	Leiphrakpam, Premila D\|Rajput, Ashwani\|Mathiesen, Michelle\|Agarwal, Ekta\|Lazenby, Audrey J\|Are, Chandrakanth\|Brattain, Michael G\|Chowdhury, Sanjib
PMID:	24462708

46.
Journal:	J Endocrinol. 2014 Mar 17;221(1):145-55.
Title:	IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice.
Author:	Moody, Gordon\|Beltran, Pedro J\|Mitchell, Petia\|Cajulis, Elaina\|Chung, Young-Ah\|Hwang, David\|Kendall, Richard\|Radinsky, Robert\|Cohen, Pinchas\|Calzone, Frank J
PMID:	24492468

47.
Journal:	Cancer Sci. 2014 Apr;105(4):425-30.
Title:	MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells.
Author:	Sakai, Hiroaki\|Sato, Ai\|Aihara, Yuki\|Ikarashi, Yoshinori\|Midorikawa, Yutaka\|Kracht, Michael\|Nakagama, Hitoshi\|Okamoto, Koji
PMID:	24533778

48.
Journal:	BMC Cancer. 2014 Mar 1;14:145.
Title:	Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer.
Author:	Agarwal, Ekta\|Chaudhuri, Anathbandhu\|Leiphrakpam, Premila D\|Haferbier, Katie L\|Brattain, Michael G\|Chowdhury, Sanjib
PMID:	24581231

49.
Journal:	PLoS One. 2014 Mar 7;9(3):e90916.
Title:	Polymorphisms in the insulin-like growth factor axis are associated with gastrointestinal cancer.
Author:	Ong, Jennie\|Salomon, Jody\|te Morsche, Rene H M\|Roelofs, Hennie M J\|Witteman, Ben J M\|Dura, Polat\|Lacko, Martin\|Peters, Wilbert H M
PMID:	24608110

50.
Journal:	Arch Med Res. 2014 May;45(4):318-24.
Title:	mRNA expression of IGF-1 and IGF-1R in patients with colorectal adenocarcinoma and type 2 diabetes.
Author:	Liu, Rui\|Hu, Li-Ling\|Sun, Ao\|Cao, Ya-Jing\|Tang, Tao\|Zhang, Xi-Peng\|Zhang, Qing-Huai
PMID:	24751329

51.
Journal:	Int J Oncol. 2014 Aug;45(2):611-8.
Title:	Klotho suppresses growth and invasion of colon cancer cells through inhibition of IGF1R-mediated PI3K/AKT pathway.
Author:	Li, Xin-Xiang\|Huang, Li-Yong\|Peng, Jun-Jie\|Liang, Lei\|Shi, De-Bing\|Zheng, Hong-Tu\|Cai, San-Jun
PMID:	24818842

52.
Journal:	FEBS J. 2014 Aug;281(16):3609-24.
Title:	Post-transcriptional regulation of the tumor suppressor miR-139-5p and a network of miR-139-5p-mediated mRNA interactions in colorectal cancer.
Author:	Shen, Ke\|Mao, Rurong\|Ma, Li\|Li, Yueqi\|Qiu, Yanyan\|Cui, Daling\|Le, Vanminh\|Yin, Peihao\|Ni, Lei\|Liu, Jianwen
PMID:	24942287

53.
Journal:	Oncotarget. 2014 Jun 30;5(12):4195-210.
Title:	Repression of liver colorectal metastasis by the serpin Spn4A a naturally occurring inhibitor of the constitutive secretory proprotein convertases.
Author:	Sfaxi, Fatma\|Scamuffa, Nathalie\|Lalou, Claude\|Ma, Jia\|Metrakos, Peter\|Siegfried, Geraldine\|Ragg, Hermann\|Bikfalvi, Andreas\|Calvo, Fabien\|Khatib, Abdel-Majid
PMID:	24961901

54.
Journal:	PLoS One. 2014 Aug 4;9(8):e103551.
Title:	Activated cMET and IGF1R-driven PI3K signaling predicts poor survival in colorectal cancers independent of KRAS mutational status.
Author:	Lee, Jeeyun\|Jain, Anjali\|Kim, Phillip\|Lee, Tani\|Kuller, Anne\|Princen, Fred\|In-GuDo\|Kim, Suk Hyeong\|Park, Joon Oh\|Park, Young Suk\|Singh, Sharat\|Kim, Hee Cheol
PMID:	25090459

55.
Journal:	Mol Biol Rep. 2014 Dec;41(12):8099-106.
Title:	Association of insulin-like growth factor-I receptor polymorphism with colorectal cancer development.
Author:	Stanilov, Noyko S\|Karakolev, Iliya A\|Deliysky, Tashko S\|Jovchev, Jovcho P\|Stanilova, Spaska A
PMID:	25189651

56.
Journal:	J Biomed Sci. 2014 Oct 5;21:95.
Title:	MicroRNA-5p and -3p co-expression and cross-targeting in colon cancer cells.
Author:	Choo, Kong Bung\|Soon, Yuen Loon\|Nguyen, Phan Nguyen Nhi\|Hiew, Michele Sook Yuin\|Huang, Chiu-Jung
PMID:	25287248

57.
Journal:	PLoS One. 2014 Dec 4;9(12):e114420.
Title:	MiR-143 and MiR-145 regulate IGF1R to suppress cell proliferation in colorectal cancer.
Author:	Su, Jiaojiao\|Liang, Hongwei\|Yao, Weiyan\|Wang, Nan\|Zhang, Suyang\|Yan, Xin\|Feng, Hui\|Pang, Wenjing\|Wang, Yanbo\|Wang, Xueliang\|Fu, Zhen\|Liu, Yanqing\|Zhao, Chihao\|Zhang, Junfeng\|Zhang, Chen-Yu\|Zen, Ke\|Chen, Xi\|Wang, Yalei
PMID:	25474488

58.
Journal:	Target Oncol. 2015 Mar;10(1):65-76.
Title:	Anticancer activity of the type I insulin-like growth factor receptor antagonist, ganitumab, in combination with the death receptor 5 agonist, conatumumab.
Author:	Tabernero, Josep\|Chawla, Sant P\|Kindler, Hedy\|Reckamp, Karen\|Chiorean, E Gabriela\|Azad, Nilofer S\|Lockhart, A Craig\|Hsu, Cheng-Pang\|Baker, Nigel F\|Galimi, Francesco\|Beltran, Pedro\|Baselga, Jose
PMID:	24816908

59.
Journal:	Clin Cancer Res. 2015 Feb 15;21(4):701-11.
Title:	A phase I study of continuous oral dosing of OSI-906, a dual inhibitor of insulin-like growth factor-1 and insulin receptors, in patients with advanced solid tumors.
Author:	Puzanov, Igor\|Lindsay, Colin R\|Goff, Laura\|Sosman, Jeff\|Gilbert, Jill\|Berlin, Jordan\|Poondru, Srinivasu\|Simantov, Ronit\|Gedrich, Rich\|Stephens, Andrew\|Chan, Emily\|Evans, T R Jeffry
PMID:	25212606

60.
Journal:	Invest New Drugs. 2015 Feb;33(1):187-93.
Title:	A phase Ib study of linsitinib (OSI-906), a dual inhibitor of IGF-1R and IR tyrosine kinase, in combination with everolimus as treatment for patients with refractory metastatic colorectal cancer.
Author:	Bendell, Johanna C\|Jones, Suzanne F\|Hart, Lowell\|Spigel, David R\|Lane, Cassie M\|Earwood, Chris\|Infante, Jeffrey R\|Barton, John\|Burris, Howard A
PMID:	25335932

61.
Journal:	Cell Biochem Biophys. 2015 Apr;71(3):1503-7.
Title:	Insulin-Like Growth Factor-1 Modulates Polycomb Cbx8 Expression and Inhibits Colon Cancer Cell Apoptosis.
Author:	Yang, Shaobo\|Liu, Wenhui\|Li, Mingyang\|Wen, Junbao\|Zhu, Min\|Xu, Shiping
PMID:	25398592

62.
Journal:	Oncotarget. 2015 Jun 20;6(17):15332-47.
Title:	Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo.
Author:	Sharon, Chetna\|Baranwal, Somesh\|Patel, Nirmita J\|Rodriguez-Agudo, Daniel\|Pandak, William M\|Majumdar, Adhip P N\|Krystal, Geoffrey\|Patel, Bhaumik B
PMID:	25895029

63.
Journal:	Biomed Pharmacother. 2015 Jul;73:12-8.
Title:	Knockdown of type I insulin-like growth factor receptor inhibits human colorectal cancer cell growth and downstream PI3K/Akt, WNT/beta-catenin signal pathways.
Author:	Zhang, Qian-yun\|Wang, Lu\|Song, Zhi-yu\|Qu, Xian-jun
PMID:	26211576

64.
Journal:	PLoS One. 2015 Aug 10;10(8):e0134948.
Title:	Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array.
Author:	Chung, Seyung\|Dwabe, Sami\|Elshimali, Yayha\|Sukhija, Hemlata\|Aroh, Clement\|Vadgama, Jaydutt V
PMID:	26258407

65.
Journal:	Mol Cancer Ther. 2015 Dec;14(12):2762-72.
Title:	BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis.
Author:	Sanderson, Michael P\|Apgar, Joshua\|Garin-Chesa, Pilar\|Hofmann, Marco H\|Kessler, Dirk\|Quant, Jens\|Savchenko, Alexander\|Schaaf, Otmar\|Treu, Matthias\|Tye, Heather\|Zahn, Stephan K\|Zoephel, Andreas\|Haaksma, Eric\|Adolf, Gunther R\|Kraut, Norbert
PMID:	26438154

66.
Journal:	Curr Cancer Drug Targets. 2015;15(8):703-15.
Title:	Prognostic and Predictive Biomarkers in Colorectal Cancer. From the Preclinical Setting to Clinical Practice.
Author:	Maurel, Joan\|Postigo, Antonio
PMID:	26452385

67.
Journal:	Clin Cancer Res. 2016 Jun 15;22(12):2897-907.
Title:	Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors.
Author:	Macaulay, Valentine M\|Middleton, Mark R\|Eckhardt, S Gail\|Rudin, Charles M\|Juergens, Rosalyn A\|Gedrich, Richard\|Gogov, Sven\|McCarthy, Sean\|Poondru, Srinivasu\|Stephens, Andrew W\|Gadgeel, Shirish M
PMID:	26831715

68.
Journal:	BMC Syst Biol. 2016 Feb 9;10:15.
Title:	Quantitative analysis of insulin-like growth factor 2 receptor and insulin-like growth factor binding proteins to identify control mechanisms for insulin-like growth factor 1 receptor phosphorylation.
Author:	Tian, Dan\|Mitchell, Isaiah\|Kreeger, Pamela K
PMID:	26861122

69.
Journal:	Onco Targets Ther. 2016 Mar 31;9:1899-920.
Title:	Advances in targeted and immunobased therapies for colorectal cancer in the genomic era.
Author:	Seow, Heng Fong\|Yip, Wai Kien\|Fifis, Theodora
PMID:	27099521

70.
Journal:	PLoS One. 2016 May 31;11(5):e0156665.
Title:	Computational Identification of Novel Stage-Specific Biomarkers in Colorectal Cancer Progression.
Author:	Palaniappan, Ashok\|Ramar, Karthick\|Ramalingam, Satish
PMID:	27243824

71.
Journal:	Gene. 2016 Oct 10;591(1):123-128.
Title:	Calycosin induces apoptosis in colorectal cancer cells, through modulating the ERbeta/MiR-95 and IGF-1R, PI3K/Akt signaling pathways.
Author:	Zhao, Xinge\|Li, Xin\|Ren, Qianyao\|Tian, Jing\|Chen, Jian
PMID:	27393650

72.
Journal:	Biomed Pharmacother. 2016 Aug;82:528-36.
Title:	IGF1R and c-met as therapeutic targets for colorectal cancer.
Author:	Shali, Hajar\|Ahmadi, Majid\|Kafil, Hossein Samadi\|Dorosti, Abbasali\|Yousefi, Mehdi
PMID:	27470393

73.
Journal:	Am J Transl Res. 2016 Jul 15;8(7):3013-22. eCollection 2016.
Title:	miR-448 suppresses proliferation and invasion by regulating IGF1R in colorectal cancer cells.
Author:	Li, Bai\|Ge, Liang\|Li, Minghe\|Wang, Lei\|Li, Zhihong
PMID:	27508021

74.
Journal:	Cancer Lett. 2016 Nov 1;382(1):32-43.
Title:	Broad RTK-targeted therapy overcomes molecular heterogeneity-driven resistance to cetuximab via vectored immunoprophylaxis in colorectal cancer.
Author:	Hu, Shi\|Dai, Haibin\|Li, Tian\|Tang, Ying\|Fu, Wenyan\|Yuan, Qingning\|Wang, Feifei\|Lv, Gaojian\|Lv, Yuanyuan\|Fan, Xiaoyan\|Zhang, Sheng\|Jin, Ruobing\|Shen, Yafeng\|Lin, Fangxing\|Ye, Xuting\|Ding, Min\|Yang, Yongji\|Lei, Changhai
PMID:	27569653

75.
Journal:	Ginekol Pol. 2016;87(8):598-604.
Title:	Does IGF-1 play a role in the biology of endometrial cancer?
Author:	Majchrzak-Baczmanska, Dominika\|Malinowski, Andrzej
PMID:	27629137

76.
Journal:	Oncotarget. 2016 Nov 8;7(45):72908-72922.
Title:	Genomic characterization of liver metastases from colorectal cancer patients.
Author:	Sayagues, Jose Maria\|Corchete, Luis Antonio\|Gutierrez, Maria Laura\|Sarasquete, Maria Eugenia\|Del Mar Abad, Maria\|Bengoechea, Oscar\|Ferminan, Encarna\|Anduaga, Maria Fernanda\|Del Carmen, Sofia\|Iglesias, Manuel\|Esteban, Carmen\|Angoso, Maria\|Alcazar, Jose Ant
PMID:	27662660

77.
Journal:	Oncotarget. 2016 Dec 6;7(49):80700-80715.
Title:	The CEA-/lo colorectal cancer cell population harbors cancer stem cells and metastatic cells.
Author:	Yan, Chang\|Hu, Yibing\|Zhang, Bo\|Mu, Lei\|Huang, Kaiyu\|Zhao, Hui\|Ma, Chensen\|Li, Xiaolan\|Tao, Deding\|Gong, Jianping\|Qin, Jichao
PMID:	27813496

78.
Journal:	Oncol Rep. 2017 Jan;37(1):631-639.
Title:	MicroRNA-302a enhances 5-fluorouracil-induced cell death in human colon cancer cells.
Author:	Liu, Na\|Li, Jie\|Zhao, Zhenghao\|Han, Jia\|Jiang, Ting\|Chen, Yanke\|Hou, Ni\|Huang, Chen
PMID:	27840990

79.
Journal:	Cancer Sci. 2017 Mar;108(3):390-397.
Title:	Downregulation of microRNA-100/microRNA-125b is associated with lymph node metastasis in early colorectal cancer with submucosal invasion.
Author:	Fujino, Yasuteru\|Takeishi, Shunsaku\|Nishida, Kensei\|Okamoto, Koichi\|Muguruma, Naoki\|Kimura, Tetsuo\|Kitamura, Shinji\|Miyamoto, Hiroshi\|Fujimoto, Akiko\|Higashijima, Jun\|Shimada, Mitsuo\|Rokutan, Kazuhito\|Takayama, Tetsuji
PMID:	28032929

80.
Journal:	Drug Des Devel Ther. 2017 Jan 11;11:177-184.
Title:	Immunotherapy for the treatment of colorectal tumors: focus on approved and in-clinical-trial monoclonal antibodies.
Author:	Francoso, Alex\|Simioni, Patricia Ucelli
PMID:	28138221

81.
Journal:	PLoS One. 2017 Apr 17;12(4):e0176096.
Title:	TGFbeta/Smad3 regulates proliferation and apoptosis through IRS-1 inhibition in colon cancer cells.
Author:	Bailey, Katie L\|Agarwal, Ekta\|Chowdhury, Sanjib\|Luo, Jiangtao\|Brattain, Michael G\|Black, Jennifer D\|Wang, Jing
PMID:	28414818

82.
Journal:	Oncotarget. 2017 Apr 25;8(17):29501-29518.
Title:	Update of IGF-1 receptor inhibitor (ganitumab, dalotuzumab, cixutumumab, teprotumumab and figitumumab) effects on cancer therapy.
Author:	Qu, Xiao\|Wu, Zhinan\|Dong, Wei\|Zhang, Tiehong\|Wang, Liguang\|Pang, Zhaofei\|Ma, Wei\|Du, Jiajun
PMID:	28427155

83.
Journal:	Onco Targets Ther. 2017 Apr 7;10:2045-2056.
Title:	Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7.
Author:	Tang, Wentao\|Ji, Meiling\|He, Guodong\|Yang, Liangliang\|Niu, Zhengchuan\|Jian, Mi\|Wei, Ye\|Ren, Li\|Xu, Jianmin
PMID:	28435295

84.
Journal:	Oncogene. 2017 Sep 21;36(38):5341-5355.
Title:	Stromal-derived IGF2 promotes colon cancer progression via paracrine and autocrine mechanisms.
Author:	Unger, C\|Kramer, N\|Unterleuthner, D\|Scherzer, M\|Burian, A\|Rudisch, A\|Stadler, M\|Schlederer, M\|Lenhardt, D\|Riedl, A\|Walter, S\|Wernitznig, A\|Kenner, L\|Hengstschlager, M\|Schuler, J\|Sommergruber, W\|Dolznig, H
PMID:	28534511

85.
Journal:	Mol Cancer Ther. 2017 Oct;16(10):2223-2233.
Title:	The IGF1R/INSR Inhibitor BI 885578 Selectively Inhibits Growth of IGF2-Overexpressing Colorectal Cancer Tumors and Potentiates the Efficacy of Anti-VEGF Therapy.
Author:	Sanderson, Michael P\|Hofmann, Marco H\|Garin-Chesa, Pilar\|Schweifer, Norbert\|Wernitznig, Andreas\|Fischer, Stefan\|Jeschko, Astrid\|Meyer, Reiner\|Moll, Jurgen\|Pecina, Thomas\|Arnhof, Heribert\|Weyer-Czernilofsky, Ulrike\|Zahn, Stephan K\|Adolf, Gunther R\|Kraut, N
PMID:	28729397

86.
Journal:	Anticancer Res. 2017 Aug;37(8):4361-4369.
Title:	The Axis of CXCR4/SDF-1 Plays a Role in Colon Cancer Cell Adhesion Through Regulation of the AKT and IGF1R Signalling Pathways.
Author:	Zheng, Fei\|Zhang, Zhongtao\|Flamini, Valentina\|Jiang, Wen G\|Cui, Yuxin
PMID:	28739729

87.
Journal:	Mol Cancer Ther. 2017 Oct;16(10):2130-2143.
Title:	Mechanisms of Resistance to NTRK Inhibitors and Therapeutic Strategies in NTRK1-Rearranged Cancers.
Author:	Fuse, Miho J\|Okada, Koutaroh\|Oh-Hara, Tomoko\|Ogura, Hayato\|Fujita, Naoya\|Katayama, Ryohei
PMID:	28751539

88.
Journal:	Cancer Lett. 2017 Oct 28;407:93-105.
Title:	Simultaneous inhibition of IGF1R and EGFR enhances the efficacy of standard treatment for colorectal cancer by the impairment of DNA repair and the induction of cell death.
Author:	Oberthur, Rabea\|Seemann, Henning\|Gehrig, Julia\|Rave-Frank, Margret\|Bremmer, Felix\|Halpape, Rovena\|Conradi, Lena-Christin\|Scharf, Jens-Gerd\|Burfeind, Peter\|Kaulfuss, Silke
PMID:	28823963

89.
Journal:	Dig Dis Sci. 2017 Nov;62(11):3040-3049.
Title:	MicroRNA-30a Inhibits Colorectal Cancer Metastasis Through Down-Regulation of Type I Insulin-Like Growth Factor Receptor.
Author:	Liu, Y C\|Park, Y R\|Kim, S L\|Lee, S T\|Kim, S W
PMID:	28932920

90.
Journal:	Int J Environ Res Public Health. 2017 Sep 28;14(10). pii: ijerph14101146.
Title:	Multiple Gene-Environment Interactions on the Angiogenesis Gene-Pathway Impact Rectal Cancer Risk and Survival.
Author:	Sharafeldin, Noha\|Slattery, Martha L\|Liu, Qi\|Franco-Villalobos, Conrado\|Caan, Bette J\|Potter, John D\|Yasui, Yutaka
PMID:	28956832

91.
Journal:	Br J Cancer. 2017 Dec 5;117(12):1733-1735.
Title:	IGF-1R: SUMO-ing its weight in chemoresistant colorectal cancer.
Author:	Goel, Ajay
PMID:	29123265

92.
Journal:	Sci Rep. 2017 Nov 22;7(1):15992.
Title:	Metformin transiently inhibits colorectal cancer cell proliferation as a result of either AMPK activation or increased ROS production.
Author:	Mogavero, Angela\|Maiorana, Maria Valeria\|Zanutto, Susanna\|Varinelli, Luca\|Bozzi, Fabio\|Belfiore, Antonino\|Volpi, Chiara C\|Gloghini, Annunziata\|Pierotti, Marco A\|Gariboldi, Manuela
PMID:	29167573

93.
Journal:	World J Gastroenterol. 2017 Dec 14;23(46):8109-8119.
Title:	Relation of the IGF/IGF1R system to autophagy in colitis and colorectal cancer.
Author:	Sipos, Ferenc\|Szekely, Hajnal\|Kis, Imre Daniel\|Tulassay, Zsolt\|Muzes, Gyorgyi
PMID:	29290648

94.
Journal:	Cancer Res. 2018 Feb 1;78(3):659-670.
Title:	Radiotherapy-Activated Cancer-Associated Fibroblasts Promote Tumor Progression through Paracrine IGF1R Activation.
Author:	Tommelein, Joke\|De Vlieghere, Elly\|Verset, Laurine\|Melsens, Elodie\|Leenders, Justine\|Descamps, Benedicte\|Debucquoy, Annelies\|Vanhove, Christian\|Pauwels, Patrick\|Gespach, Christian P\|Vral, Anne\|De Boeck, Astrid\|Haustermans, Karin\|de Tullio, Pascal\|Ceelen,
PMID:	29217764

95.
Journal:	Cell Death Dis. 2018 Apr 1;9(4):417.
Title:	CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7.
Author:	Zeng, Kaixuan\|Chen, Xiaoxiang\|Xu, Mu\|Liu, Xiangxiang\|Hu, Xiuxiu\|Xu, Tao\|Sun, Huiling\|Pan, Yuqin\|He, Bangshun\|Wang, Shukui
PMID:	29549306

96.
Journal:	Oncogene. 2018 Jun;37(25):3440-3455.
Title:	Mutant KRAS promotes liver metastasis of colorectal cancer, in part, by upregulating the MEK-Sp1-DNMT1-miR-137-YB-1-IGF-IR signaling pathway.
Author:	Chu, Po-Chen\|Lin, Peng-Chan\|Wu, Hsing-Yu\|Lin, Kuen-Tyng\|Wu, Christina\|Bekaii-Saab, Tanios\|Lin, Yih-Jyh\|Lee, Chung-Ta\|Lee, Jeng-Chang\|Chen, Ching-Shih
PMID:	29559746

97.
Journal:	J Cell Physiol. 2018 Sep;233(9):7134-7142.
Title:	Fisetin mediated apoptotic cell death in parental and Oxaliplatin/irinotecan resistant colorectal cancer cells in vitro and in vivo.
Author:	Jeng, Long-Bin\|Kumar Velmurugan, Bharath\|Chen, Ming-Cheng\|Hsu, Hsi-Hsien\|Ho, Tsung-Jung\|Day, Cecilia-Hsuan\|Lin, Yueh-Min\|Padma, V Vijaya\|Tu, Chuan-Chou\|Huang, Chih-Yang
PMID:	29574877

98.
Journal:	J Biol Chem. 2018 May 25;293(21):8242-8254.
Title:	TGFbeta and IGF1R signaling activates protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells.
Author:	Leiphrakpam, Premila D\|Brattain, Michael G\|Black, Jennifer D\|Wang, Jing
PMID:	29599290

99.
Journal:	Cell Cycle. 2018;17(10):1212-1219.
Title:	IGF1/IGF1R and microRNA let-7e down-regulate each other and modulate proliferation and migration of colorectal cancer cells.
Author:	Li, Zhenjun\|Pan, Weihuo\|Shen, Yi\|Chen, Zhiliang\|Zhang, Lihua\|Zhang, Yuping\|Luo, Quan\|Ying, Xiaojiang
PMID:	29886785

100.
Journal:	Am J Cancer Res. 2018 May 1;8(5):810-823. eCollection 2018.
Title:	NUDCD1 promotes metastasis through inducing EMT and inhibiting apoptosis in colorectal cancer.
Author:	Han, Bin\|Zhang, Yuan-Yuan\|Xu, Ke\|Bai, Yang\|Wan, Li-Hong\|Miao, Shi-Kun\|Zhang, Ke-Xian\|Zhang, Hong-Wei\|Liu, Yin\|Zhou, Li-Ming
PMID:	29888104

101.
Journal:	Oncogene. 2018 Jun 12. pii: 10.1038/s41388-018-0362-5.
Title:	beta-catenin/TCF activity regulates IGF-1R tyrosine kinase inhibitor sensitivity in colon cancer.
Author:	Lee, Hani\|Kim, Nayoung\|Yoo, Young Ji\|Kim, Hyejin\|Jeong, Euna\|Choi, SeokGyeong\|Moon, Sung Un\|Oh, Seung Hyun\|Mills, Gordon B\|Yoon, Sukjoon\|Kim, Woo-Young
PMID:	29895971

102.
Journal:	Biomed Pharmacother. 2018 Oct;106:763-769.
Title:	MiR-185 enhances radiosensitivity of colorectal cancer cells by targeting IGF1R and IGF2.
Author:	Afshar, Saeid\|Najafi, Rezvan\|Sedighi Pashaki, Abdolazim\|Sharifi, Mohammadreza\|Nikzad, Safoora\|Gholami, Mohammad Hadi\|Khoshghadam, Alireza\|Amini, Razieh\|Karimi, Jamshid\|Saidijam, Massoud
PMID:	29990869