Primary Site >> Biliary tract Cancer
Gene >> IDH2
| 1. | |||||||||||
| Journal: | Oncologist. 2012;17(1):72-9. | ||||||||||
| Title: | Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. | ||||||||||
| Author: | Borger, Darrell R|Tanabe, Kenneth K|Fan, Kenneth C|Lopez, Hector U|Fantin, Valeria R|Straley, Kimberly S|Schenkein, David P|Hezel, Aram F|Ancukiewicz, Marek|Liebman, Hannah M|Kwak, Eunice L|Clark, Jeffrey W|Ryan, David P|Deshpande, Vikram|Dias-Santagata, | ||||||||||
| PMID: | 22180306 | ||||||||||
| 2. | |||||||||||
| Journal: | Oncogene. 2013 Jun 20;32(25):3091-100. | ||||||||||
| Title: | Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. | ||||||||||
| Author: | Wang, P|Dong, Q|Zhang, C|Kuan, P-F|Liu, Y|Jeck, W R|Andersen, J B|Jiang, W|Savich, G L|Tan, T-X|Auman, J T|Hoskins, J M|Misher, A D|Moser, C D|Yourstone, S M|Kim, J W|Cibulskis, K|Getz, G|Hunt, H V|Thorgeirsson, S S|Roberts, L R|Ye, D|Guan, K-L|Xiong, Y|Q | ||||||||||
| PMID: | 22824796 | ||||||||||
| 3. | |||||||||||
| Journal: | Nat Genet. 2013 Dec;45(12):1474-8. | ||||||||||
| Title: | Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers. | ||||||||||
| Author: | Chan-On, Waraporn|Nairismagi, Maarja-Liisa|Ong, Choon Kiat|Lim, Weng Khong|Dima, Simona|Pairojkul, Chawalit|Lim, Kiat Hon|McPherson, John R|Cutcutache, Ioana|Heng, Hong Lee|Ooi, London|Chung, Alexander|Chow, Pierce|Cheow, Peng Chung|Lee, Ser Yee|Choo, Su | ||||||||||
| PMID: | 24185513 | ||||||||||
| 4. | |||||||||||
| Journal: | Oncogene. 2013 Oct 10;32(41):4861-70. | ||||||||||
| Title: | Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapies. | ||||||||||
| Author: | Sia, D|Tovar, V|Moeini, A|Llovet, J M | ||||||||||
| PMID: | 23318457 | ||||||||||
| 5. | |||||||||||
| Journal: | Clin Cancer Res. 2014 Apr 1;20(7):1884-90. | ||||||||||
| Title: | Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma. | ||||||||||
| Author: | Borger, Darrell R|Goyal, Lipika|Yau, Thomas|Poon, Ronnie T|Ancukiewicz, Marek|Deshpande, Vikram|Christiani, David C|Liebman, Hannah M|Yang, Hua|Kim, Hyeryun|Yen, Katharine|Faris, Jason E|Iafrate, A John|Kwak, Eunice L|Clark, Jeffrey W|Allen, Jill N|Blaszk | ||||||||||
| PMID: | 24478380 | ||||||||||
| 6. | |||||||||||
| Journal: | J Hepatobiliary Pancreat Sci. 2014 Jun;21(6):380-7. | ||||||||||
| Title: | Genomic and transcriptional alterations of cholangiocarcinoma. | ||||||||||
| Author: | Ito, Takeshi|Sakurai-Yageta, Mika|Goto, Akiteru|Pairojkul, Chawalit|Yongvanit, Puangrat|Murakami, Yoshinori | ||||||||||
| PMID: | 24532422 | ||||||||||
| 7. | |||||||||||
| Journal: | Curr Opin Gastroenterol. 2014 May;30(3):295-302. | ||||||||||
| Title: | Mutations of isocitrate dehydrogenase 1 and 2 in intrahepatic cholangiocarcinoma. | ||||||||||
| Author: | Grassian, Alexandra R|Pagliarini, Raymond|Chiang, Derek Y | ||||||||||
| PMID: | 24569570 | ||||||||||
| 8. | |||||||||||
| Journal: | Biochim Biophys Acta. 2014 Dec;1846(2):326-41. | ||||||||||
| Title: | The driver and passenger effects of isocitrate dehydrogenase 1 and 2 mutations in oncogenesis and survival prolongation. | ||||||||||
| Author: | Molenaar, Remco J|Radivoyevitch, Tomas|Maciejewski, Jaroslaw P|van Noorden, Cornelis J F|Bleeker, Fonnet E | ||||||||||
| PMID: | 24880135 | ||||||||||
| 9. | |||||||||||
| Journal: | Ann Surg Oncol. 2014 Nov;21(12):3827-34. | ||||||||||
| Title: | Genomic profiling of intrahepatic cholangiocarcinoma: refining prognosis and identifying therapeutic targets. | ||||||||||
| Author: | Zhu, Andrew X|Borger, Darrell R|Kim, Yuhree|Cosgrove, David|Ejaz, Aslam|Alexandrescu, Sorin|Groeschl, Ryan Thomas|Deshpande, Vikram|Lindberg, James M|Ferrone, Cristina|Sempoux, Christine|Yau, Thomas|Poon, Ronnie|Popescu, Irinel|Bauer, Todd W|Gamblin, T Cl | ||||||||||
| PMID: | 24889489 | ||||||||||
| 10. | |||||||||||
| Journal: | Nature. 2014 Sep 4;513(7516):110-4. | ||||||||||
| Title: | Mutant IDH inhibits HNF-4alpha to block hepatocyte differentiation and promote biliary cancer. | ||||||||||
| Author: | Saha, Supriya K|Parachoniak, Christine A|Ghanta, Krishna S|Fitamant, Julien|Ross, Kenneth N|Najem, Mortada S|Gurumurthy, Sushma|Akbay, Esra A|Sia, Daniela|Cornella, Helena|Miltiadous, Oriana|Walesky, Chad|Deshpande, Vikram|Zhu, Andrew X|Hezel, Aram F|Yen, | ||||||||||
| PMID: | 25043045 | ||||||||||
| 11. | |||||||||||
| Journal: | Cell Cycle. 2014;13(20):3176-82. | ||||||||||
| Title: | IDH mutations in liver cell plasticity and biliary cancer. | ||||||||||
| Author: | Saha, Supriya K|Parachoniak, Christine A|Bardeesy, Nabeel | ||||||||||
| PMID: | 25485496 | ||||||||||
| 12. | |||||||||||
| Journal: | Hum Pathol. 2015 Feb;46(2):322-6. | ||||||||||
| Title: | Increased plasma d-2-hydroxyglutarate in isocitrate dehydrogenase 2-mutated blastic plasmacytoid dendritic cell neoplasm. | ||||||||||
| Author: | Rakheja, Dinesh|Fuda, Franklin|Vandergriff, Travis|Boriack, Richard|Medeiros, Bruno C|Frankel, Arthur E|Chen, Weina | ||||||||||
| PMID: | 25481493 | ||||||||||
| 13. | |||||||||||
| Journal: | Oncologist. 2015 Sep;20(9):1019-27. | ||||||||||
| Title: | Prognosis and Clinicopathologic Features of Patients With Advanced Stage Isocitrate Dehydrogenase (IDH) Mutant and IDH Wild-Type Intrahepatic Cholangiocarcinoma. | ||||||||||
| Author: | Goyal, Lipika|Govindan, Aparna|Sheth, Rahul A|Nardi, Valentina|Blaszkowsky, Lawrence S|Faris, Jason E|Clark, Jeffrey W|Ryan, David P|Kwak, Eunice L|Allen, Jill N|Murphy, Janet E|Saha, Supriya K|Hong, Theodore S|Wo, Jennifer Y|Ferrone, Cristina R|Tanabe, K | ||||||||||
| PMID: | 26245674 | ||||||||||
| 14. | |||||||||||
| Journal: | Exp Mol Pathol. 2015 Oct;99(2):344-53. | ||||||||||
| Title: | Genome wide DNA copy number analysis in cholangiocarcinoma using high resolution molecular inversion probe single nucleotide polymorphism assay. | ||||||||||
| Author: | Arnold, Alexander|Bahra, Marcus|Lenze, Dido|Bradtmoller, Maren|Guse, Katrin|Gehlhaar, Claire|Blaker, Hendrik|Heppner, Frank L|Koch, Arend | ||||||||||
| PMID: | 26260902 | ||||||||||
| 15. | |||||||||||
| Journal: | Asian Pac J Cancer Prev. 2015;16(14):5875-81. | ||||||||||
| Title: | Altered Expression of Oxidative Metabolism Related Genes in Cholangiocarcinomas. | ||||||||||
| Author: | Aukkanimart, Ratchadawan|Boonmars, Thidarut|Juasook, Amornrat|Sriraj, Pranee|Boonjaraspinyo, Sirintip|Wu, Zhiliang|Laummuanwai, Porntip|Pairojkul, Chawalit|Khuntikeo, Narong|Rattanasuwan, Panaratana | ||||||||||
| PMID: | 26320466 | ||||||||||
| 16. | |||||||||||
| Journal: | J Blood Med. 2016 Sep 2;7:171-80. | ||||||||||
| Title: | IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives. | ||||||||||
| Author: | Mondesir, Johanna|Willekens, Christophe|Touat, Mehdi|de Botton, Stephane | ||||||||||
| PMID: | 27621679 | ||||||||||
| 17. | |||||||||||
| Journal: | Pathol Int. 2016 Oct;66(10):578-582. | ||||||||||
| Title: | Immunohistochemistry using monoclonal antibody MsMab-2 is useful to detect IDH1 R132L in intrahepatic cholangiocarcinoma. | ||||||||||
| Author: | Hayashi, Akimasa|Misumi, Kento|Shibahara, Junji|Kokudo, Norihiro|Kato, Yukinari|Fukayama, Masashi | ||||||||||
| PMID: | 27595804 | ||||||||||
| 18. | |||||||||||
| Journal: | Cancer Discov. 2016 Jul;6(7):727-39. | ||||||||||
| Title: | Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. | ||||||||||
| Author: | Saha, Supriya K|Gordan, John D|Kleinstiver, Benjamin P|Vu, Phuong|Najem, Mortada S|Yeo, Jia-Chi|Shi, Lei|Kato, Yasutaka|Levin, Rebecca S|Webber, James T|Damon, Leah J|Egan, Regina K|Greninger, Patricia|McDermott, Ultan|Garnett, Mathew J|Jenkins, Roger L|R | ||||||||||
| PMID: | 27231123 | ||||||||||
| 19. | |||||||||||
| Journal: | Oncotarget. 2016 Jul 19;7(29):46750-46767. | ||||||||||
| Title: | The landscape of targeted therapies for cholangiocarcinoma: current status and emerging targets. | ||||||||||
| Author: | Chong, Dawn Q|Zhu, Andrew X | ||||||||||
| PMID: | 27102149 | ||||||||||
| 20. | |||||||||||
| Journal: | Clin Cancer Res. 2016 Apr 15;22(8):1837-42. | ||||||||||
| Title: | Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer. | ||||||||||
| Author: | Clark, Owen|Yen, Katharine|Mellinghoff, Ingo K | ||||||||||
| PMID: | 26819452 | ||||||||||
| 21. | |||||||||||
| Journal: | Clin Cancer Res. 2016 Jan 15;22(2):291-300. | ||||||||||
| Title: | Molecular Pathogenesis and Targeted Therapies for Intrahepatic Cholangiocarcinoma. | ||||||||||
| Author: | Moeini, Agrin|Sia, Daniela|Bardeesy, Nabeel|Mazzaferro, Vincenzo|Llovet, Josep M | ||||||||||
| PMID: | 26405193 | ||||||||||
| 22. | |||||||||||
| Journal: | BMC Res Notes. 2016 Feb 27;9:126. | ||||||||||
| Title: | Maffucci syndrome and neoplasms: a case report and review of the literature. | ||||||||||
| Author: | Prokopchuk, Olga|Andres, Stephanie|Becker, Karen|Holzapfel, Konstantin|Hartmann, Daniel|Friess, Helmut | ||||||||||
| PMID: | 26920730 | ||||||||||
| 23. | |||||||||||
| Journal: | Cancer Discov. 2017 Sep;7(9):943-962. | ||||||||||
| Title: | New Horizons for Precision Medicine in Biliary Tract Cancers. | ||||||||||
| Author: | Valle, Juan W|Lamarca, Angela|Goyal, Lipika|Barriuso, Jorge|Zhu, Andrew X | ||||||||||
| PMID: | 28818953 | ||||||||||
| 24. | |||||||||||
| Journal: | Ecancermedicalscience. 2017 Aug 7;11:757. | ||||||||||
| Title: | Mutational frequency of KRAS, NRAS, IDH2, PIK3CA, and EGFR in North Indian gallbladder cancer patients. | ||||||||||
| Author: | Sharma, Aarti|Kumar, Ashok|Kumari, Niraj|Krishnani, Narendra|Rastogi, Neeraj | ||||||||||
| PMID: | 28900470 | ||||||||||
| 25. | |||||||||||
| Journal: | J Gastrointest Oncol. 2017 Jun;8(3):430-440. | ||||||||||
| Title: | Current biologics for treatment of biliary tract cancers. | ||||||||||
| Author: | Zhao, Diana Y|Lim, Kian-Huat | ||||||||||
| PMID: | 28736630 | ||||||||||
| 26. | |||||||||||
| Journal: | BMJ Open. 2017 Jun 10;7(6):e014961. | ||||||||||
| Title: | Study protocol of a phase IB/II clinical trial of metformin and chloroquine in patients with IDH1-mutated or IDH2-mutated solid tumours. | ||||||||||
| Author: | Molenaar, Remco J|Coelen, Robert J S|Khurshed, Mohammed|Roos, Eva|Caan, Matthan W A|van Linde, Myra E|Kouwenhoven, Mathilde|Bramer, Jos A M|Bovee, Judith V M G|Mathot, Ron A|Klumpen, Heinz-Josef|van Laarhoven, Hanneke W M|van Noorden, Cornelis J F|Vandert | ||||||||||
| PMID: | 28601826 | ||||||||||
| 27. | |||||||||||
| Journal: | Hum Pathol. 2017 Jun;64:118-127. | ||||||||||
| Title: | Clinicopathological, radiologic, and molecular study of 23 combined hepatocellular-cholangiocarcinomas with stem cell features, cholangiolocellular type. | ||||||||||
| Author: | Chen, Jun|He, Jian|Deng, Min|Wu, Hong-Yan|Shi, Jiong|Mao, Liang|Sun, Qi|Tang, Min|Fan, Xiang-Shan|Qiu, Yu-Dong|Huang, Qin | ||||||||||
| PMID: | 28431889 | ||||||||||
| 28. | |||||||||||
| Journal: | J Hepatol. 2017 Sep;67(3):632-644. | ||||||||||
| Title: | Emerging molecular therapeutic targets for cholangiocarcinoma. | ||||||||||
| Author: | Rizvi, Sumera|Gores, Gregory J | ||||||||||
| PMID: | 28389139 | ||||||||||
| 29. | |||||||||||
| Journal: | Annu Rev Biochem. 2017 Jun 20;86:305-331. | ||||||||||
| Title: | Isocitrate Dehydrogenase Mutation and (R)-2-Hydroxyglutarate: From Basic Discovery to Therapeutics Development. | ||||||||||
| Author: | Dang, Lenny|Su, Shin-San Michael | ||||||||||
| PMID: | 28375741 | ||||||||||
| 30. | |||||||||||
| Journal: | Eur J Cancer. 2018 Feb;90:83-91. | ||||||||||
| Title: | Circulating oncometabolite D-2-hydroxyglutarate enantiomer is a surrogate marker of isocitrate dehydrogenase-mutated intrahepatic cholangiocarcinomas. | ||||||||||
| Author: | Delahousse, Julia|Verlingue, Loic|Broutin, Sophie|Legoupil, Clemence|Touat, Mehdi|Doucet, Ludovic|Ammari, Samy|Lacroix, Ludovic|Ducreux, Michel|Scoazec, Jean-Yves|Malka, David|Paci, Angelo|Hollebecque, Antoine | ||||||||||
| PMID: | 29274619 | ||||||||||
| 31. | |||||||||||
| Journal: | Cancer Control. 2018 Jan-Mar;25(1):1073274817744658. | ||||||||||
| Title: | Primary Liver Cancers, Part 2: Progression Pathways and Carcinogenesis. | ||||||||||
| Author: | Jiang, Kun|Centeno, Barbara A | ||||||||||
| PMID: | 29353494 | ||||||||||
| 32. | |||||||||||
| Journal: | Expert Opin Emerg Drugs. 2018 Mar;23(1):63-75. | ||||||||||
| Title: | Emerging molecular target antagonists for the treatment of biliary tract cancer. | ||||||||||
| Author: | Lombardi, Pasquale|Marino, Donatella|Fenocchio, Elisabetta|Chila, Giovanna|Aglietta, Massimo|Leone, Francesco | ||||||||||
| PMID: | 29468924 | ||||||||||
| 33. | |||||||||||
| Journal: | Clin Lab Med. 2018 Jun;38(2):367-384. | ||||||||||
| Title: | Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gallbladder, and Extrahepatic Biliary Tract: 2018 Update. | ||||||||||
| Author: | Zhang, Lei|Bluth, Martin H|Bhalla, Amarpreet | ||||||||||
| PMID: | 29776636 | ||||||||||
| 34. | |||||||||||
| Journal: | Cancer Sci. 2018 Aug 28. | ||||||||||
| Title: | Isocitrate dehydrogenase 1 mutation sensitizes intrahepatic cholangiocarcinoma to the BET inhibitor JQ1. | ||||||||||
| Author: | Fujiwara, Hiroaki|Tateishi, Keisuke|Kato, Hiroyuki|Nakatsuka, Takuma|Yamamoto, Keisuke|Tanaka, Yasuo|Ijichi, Hideaki|Takahara, Naminatsu|Mizuno, Suguru|Kogure, Hirofumi|Matsubara, Saburo|Nakai, Yousuke|Koike, Kazuhiko | ||||||||||
| PMID: | 30156013 | ||||||||||
| 35. | |||||||||||
| Journal: | Front Genet. 2018 Aug 15;9:309. | ||||||||||
| Title: | Emergence of Intrahepatic Cholangiocarcinoma: How High-Throughput Technologies Expedite the Solutions for a Rare Cancer Type. | ||||||||||
| Author: | Shiao, Meng-Shin|Chiablaem, Khajeelak|Charoensawan, Varodom|Ngamphaiboon, Nuttapong|Jinawath, Natini | ||||||||||
| PMID: | 30158952 | ||||||||||
| 36. | |||||||||||
| Journal: | Mod Pathol. 2018 Sep 11. pii: 10.1038/s41379-018-0126-3. | ||||||||||
| Title: | The role of a monoclonal antibody 11C8B1 as a diagnostic marker of IDH2-mutated sinonasal undifferentiated carcinoma. | ||||||||||
| Author: | Dogan, Snjezana|Frosina, Denise|Fayad, Miriam|de Oliveira, Thais Basili|Alemar, Barbara|Rosenblum, Marc|Tang, Laura H|Hameed, Meera|Xu, Bin|Ghossein, Ronald A|Chute, Deborah J|Weigelt, Britta|Jungbluth, Achim A | ||||||||||
| PMID: | 30206411 | ||||||||||