Primary Site >> Pancreatic Cancer

Gene >> GCG

Journal: J Clin Endocrinol Metab. 1985 Sep;61(3):472-9.
Title: Molecular forms of glucagon-like peptide-1 in human pancreas and glucagonomas.
Author: Uttenthal, L O|Ghiglione, M|George, S K|Bishop, A E|Polak, J M|Bloom, S R
PMID: 2991321
Journal: Mol Endocrinol. 1992 Dec;6(12):2175-84.
Title: Inhibition of pancreatic glucagon gene expression in mice bearing a subcutaneous glucagon-producing GLUTag transplantable tumor.
Author: Drucker, D J|Lee, Y C|Asa, S L|Brubaker, P L
PMID: 1491697
Journal: Diabetes Res Clin Pract. 1994 Aug;25(1):43-9.
Title: Glucagon-like peptide-1 (GLP-1) molecular forms in human pancreatic endocrine tumors resemble those in intestine rather than pancreas.
Author: Tateishi, K|Shima, K|Funakoshi, A|Yasunami, Y|Iwamoto, N|Matsuoka, Y
PMID: 7835211
Journal: Anticancer Res. 1996 Nov-Dec;16(6B):3761-6.
Title: Concomitant point mutation of tumor suppressor gene p53 and oncogene c-N-ras in malignant neuroendocrine pancreatic tumor.
Author: Hrascan, R|Pavelic, K|Pavicic, D|Krizanac, S|Stajcer-Sittic, V|Pecur, L|Spaventi, S|Klimpfinger, M|Pavelic, J
PMID: 9042254
Journal: Diabetes. 1999 Dec;48(12):2358-66.
Title: Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells.
Author: Zhou, J|Wang, X|Pineyro, M A|Egan, J M
PMID: 10580424
Journal: J Nucl Med. 2006 Dec;47(12):2025-33.
Title: [Lys40(Ahx-DTPA-111In)NH2]exendin-4, a very promising ligand for glucagon-like peptide-1 (GLP-1) receptor targeting.
Author: Wild, Damian|Behe, Martin|Wicki, Andreas|Storch, Daniel|Waser, Beatrice|Gotthardt, Martin|Keil, Boris|Christofori, Gerhard|Reubi, Jean Claude|Macke, Helmut R
PMID: 17138746
Journal: Carcinogenesis. 2010 Apr;31(4):666-70.
Title: Genotype and haplotype analysis of TP53 gene and the risk of pancreatic cancer: an association study in the Czech Republic.
Author: Naccarati, A|Pardini, B|Polakova, V|Smerhovsky, Z|Vodickova, L|Soucek, P|Vrana, D|Holcatova, I|Ryska, M|Vodicka, P
PMID: 20110284
Journal: Gastroenterology. 2010 Jun;138(7):2519-30.
Title: Differentiation of pancreatic acinar cells to hepatocytes requires an intermediate cell type.
Author: Wu, Sung-Yu|Hsieh, Chi-Che|Wu, Ruei-Ren|Susanto, Jimmy|Liu, Tsung-Ta|Shen, Chia-Rui|Chen, Yu|Su, Chien-Chang|Chang, Fang-Pei|Chang, Hsiao-Min|Tosh, David|Shen, Chia-Ning
PMID: 20178796
Journal: Life Sci. 2011 Jan 31;88(5-6):218-25.
Title: Identification of serum proteins involved in pancreatic cancer cachexia.
Author: Felix, Klaus|Fakelman, Frederik|Hartmann, Daniel|Giese, Nathalia A|Gaida, Matthias M|Schnolzer, Martina|Flad, Thomas|Buchler, Markus W|Werner, Jens
PMID: 21094171
Journal: Gastroenterology. 2011 Jul;141(1):150-6.
Title: Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies.
Author: Elashoff, Michael|Matveyenko, Aleksey V|Gier, Belinda|Elashoff, Robert|Butler, Peter C
PMID: 21334333
Journal: Diabetes Metab Res Rev. 2011 Sep;27(6):528-42.
Title: The safety and tolerability of GLP-1 receptor agonists in the treatment of type 2 diabetes: a review.
Author: Aroda, Vanita R|Ratner, Robert
PMID: 21484979
Journal: J Nucl Med. 2011 Jul;52(7):1073-8.
Title: Glucagon-like peptide-1 versus somatostatin receptor targeting reveals 2 distinct forms of malignant insulinomas.
Author: Wild, Damian|Christ, Emanuel|Caplin, Martyn E|Kurzawinski, Tom R|Forrer, Flavio|Brandle, Michael|Seufert, Jochen|Weber, Wolfgang A|Bomanji, Jamshed|Perren, Aurel|Ell, Peter J|Reubi, Jean Claude
PMID: 21680696
Journal: J Virol. 2011 Dec;85(23):12759-68.
Title: A novel pancreatropic coxsackievirus vector expressing glucagon-like peptide 1 reduces hyperglycemia in streptozotocin-treated mice.
Author: Dan, Meixia|Chantler, Janet K
PMID: 21937637
Journal: Int J Oncol. 2012 Jan;40(1):40-6.
Title: Dickkopf-3 maintains the PANC-1 human pancreatic tumor cells in a dedifferentiated state.
Author: Zenzmaier, Christoph|Hermann, Martin|Hengster, Paul|Berger, Peter
PMID: 21879258
Journal: Endocr Relat Cancer. 2012 Sep 5;19(5):F77-88.
Title: GLP1 and cancer: friend or foe?
Author: Vangoitsenhoven, Roman|Mathieu, Chantal|Van der Schueren, Bart
PMID: 22691625
Journal: Eur J Nucl Med Mol Imaging. 2012 Mar;39(3):463-73.
Title: 18F-radiolabeled analogs of exendin-4 for PET imaging of GLP-1 in insulinoma.
Author: Kiesewetter, Dale O|Gao, Haokao|Ma, Ying|Niu, Gang|Quan, Qimeng|Guo, Ning|Chen, Xiaoyuan
PMID: 22170321
Journal: Eur J Intern Med. 2013 Apr;24(3):207-12.
Title: Incretin-based therapies in the treatment of type 2 diabetes--more than meets the eye?
Author: Labuzek, Krzysztof|Kozlowski, Michal|Szkudlapski, Dawid|Sikorska, Patrycja|Kozlowska, Monika|Okopien, Boguslaw
PMID: 23375875
Journal: JAMA Intern Med. 2013 Apr 8;173(7):534-9.
Title: Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study.
Author: Singh, Sonal|Chang, Hsien-Yen|Richards, Thomas M|Weiner, Jonathan P|Clark, Jeanne M|Segal, Jodi B
PMID: 23440284
Journal: Diabetes Care. 2013 Jul;36(7):2126-32.
Title: A critical analysis of the clinical use of incretin-based therapies: The benefits by far outweigh the potential risks.
Author: Nauck, Michael A
PMID: 23645884
Journal: Diabetes Care. 2013 Jul;36(7):2118-25.
Title: A critical analysis of the clinical use of incretin-based therapies: Are the GLP-1 therapies safe?
Author: Butler, Peter C|Elashoff, Michael|Elashoff, Robert|Gale, Edwin A M
PMID: 23645885
Journal: Diabet Med. 2013 Oct;30(10):1148-55.
Title: The potential risks of pancreatitis and pancreatic cancer with GLP-1-based therapies are far outweighed by the proven and potential (cardiovascular) benefits.
Author: Ryder, R E J
PMID: 24073725
Journal: Rev Diabet Stud. 2014 Fall-Winter;11(3-4):202-30.
Title: Adverse Effects of GLP-1 Receptor Agonists.
Author: Filippatos, Theodosios D|Panagiotopoulou, Thalia V|Elisaf, Moses S
PMID: 26177483
Journal: Pancreas. 2014 Jan;43(1):1-6.
Title: Expression of glucagon-like Peptide 1 receptor and its effects on biologic behavior in pancreatic neuroendocrine tumors.
Author: Cases, Ana Ines|Ohtsuka, Takao|Fujino, Minoru|Ideno, Noboru|Kozono, Shingo|Zhao, Ming|Ohuchida, Kenoki|Aishima, Shinichi|Nomura, Masatoshi|Oda, Yoshinao|Mizumoto, Kazuhiro|Tanaka, Masao
PMID: 24326362
Journal: Drug Saf. 2014 Dec;37(12):1003-10.
Title: Balancing benefits and risks in patients receiving incretin-based therapies: focus on cardiovascular and pancreatic side effects.
Author: Haluzik, Martin|Mraz, Milos|Svacina, Stepan
PMID: 25391858
Journal: Curr Med Res Opin. 2014 Dec;30(12):2471-81.
Title: Incretin-mimetic therapies and pancreatic disease: a review of observational data.
Author: Suarez, Elizabeth A|Koro, Carol E|Christian, Jennifer B|Spector, Alicia D|Araujo, Andre B|Abraham, Sybil
PMID: 25180611
Journal: Nucl Med Biol. 2014 Jul;41(6):471-6.
Title: Pre-clinical evaluation of [(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4 for imaging of insulinoma.
Author: Selvaraju, Ram Kumar|Velikyan, Irina|Asplund, Veronika|Johansson, Lars|Wu, Zhanhong|Todorov, Ivan|Shively, Jack|Kandeel, Fouad|Eriksson, Barbro|Korsgren, Olle|Eriksson, Olof
PMID: 24857864
Journal: Diabetes Obes Metab. 2014 Sep;16(9):850-60.
Title: Activation of glucagon-like peptide-1 receptor inhibits tumourigenicity and metastasis of human pancreatic cancer cells via PI3K/Akt pathway.
Author: Zhao, H|Wang, L|Wei, R|Xiu, D|Tao, M|Ke, J|Liu, Y|Yang, J|Hong, T
PMID: 24641303
Journal: Drugs. 2014 Feb;74(2):223-42.
Title: Sitagliptin: a review of its use in patients with type 2 diabetes mellitus.
Author: Plosker, Greg L
PMID: 24407560
Journal: Diabetes. 2014 Apr;63(4):1303-14.
Title: Occurrence of spontaneous pancreatic lesions in normal and diabetic rats: a potential confounding factor in the nonclinical assessment of GLP-1-based therapies.
Author: Chadwick, Kristina D|Fletcher, Anthony M|Parrula, M Cecilia|Bonner-Weir, Susan|Mangipudy, Raja S|Janovitz, Evan|Graziano, Michael J|Roy, Denis|Reilly, Timothy P
PMID: 24222349
Journal: Am J Physiol Endocrinol Metab. 2014 Jun 15;306(12):E1431-41.
Title: Activation of glucagon-like peptide-1 receptor inhibits growth and promotes apoptosis of human pancreatic cancer cells in a cAMP-dependent manner.
Author: Zhao, Hejun|Wei, Rui|Wang, Liang|Tian, Qing|Tao, Ming|Ke, Jing|Liu, Ye|Hou, Wenfang|Zhang, Lin|Yang, Jin|Hong, Tianpei
PMID: 24801389
Journal: Expert Opin Drug Saf. 2015 Jan;14(1):171-80.
Title: Adverse drug reactions associated with the use of liraglutide in patients with type 2 diabetes--focus on pancreatitis and pancreas cancer.
Author: Chalmer, Thor|Almdal, Thomas P|Vilsboll, Tina|Knop, Filip K
PMID: 25363438
Journal: PLoS One. 2015 Jul 20;10(7):e0133812.
Title: Pancreatic Neuroendocrine Tumors in Mice Deficient in Proglucagon-Derived Peptides.
Author: Takano, Yuko|Kasai, Kenji|Takagishi, Yoshiko|Kikumori, Toyone|Imai, Tsuneo|Murata, Yoshiharu|Hayashi, Yoshitaka
PMID: 26192435
Journal: Oncol Rep. 2015 Oct;34(4):1717-25.
Title: Significance of expression of glucagon-like peptide 1 receptor in pancreatic cancer.
Author: Cases, Ana Ines|Ohtsuka, Takao|Kimura, Hideyo|Zheng, Biao|Shindo, Koji|Oda, Yoshinao|Mizumoto, Kazuhiro|Nakamura, Masafumi|Tanaka, Masao
PMID: 26238361
Journal: Int J Cardiol. 2016 Jan 1;202:731-5.
Title: The importance of Pharmacovigilance for the drug safety: Focus on cardiovascular profile of incretin-based therapy.
Author: Sportiello, Liberata|Rafaniello, Concetta|Scavone, Cristina|Vitale, Cristiana|Rossi, Francesco|Capuano, Annalisa
PMID: 26461922
Journal: Pancreatology. 2016 Jan-Feb;16(1):2-7.
Title: GLP-1 mimetic drugs and the risk of exocrine pancreatic disease: Cell and animal studies.
Author: Williams, John A
PMID: 26751948
Journal: Pancreatology. 2017 Jan - Feb;17(1):89-94.
Title: Lower plasma levels of glucose-dependent insulinotropic peptide (GIP) and pancreatic polypeptide (PP) in patients with ductal adenocarcinoma of the pancreas and their relation to the presence of impaired glucoregulation and weight loss.
Author: Skrha, Jan|Busek, Petr|Uhrova, Jana|Hrabal, Petr|Kmochova, Klara|Laclav, Martin|Bunganic, Bohus|Fric, Premysl
PMID: 28027898
Journal: Lancet Diabetes Endocrinol. 2017 May;5(5):355-366.
Title: Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-naive patients with type 2 diabetes (SUSTAIN 4): a randomised, open-label, parallel-group, multicentre, mul
Author: Aroda, Vanita R|Bain, Stephen C|Cariou, Bertrand|Piletic, Milivoj|Rose, Ludger|Axelsen, Mads|Rowe, Everton|DeVries, J Hans
PMID: 28344112
Journal: Cardiovasc Diabetol. 2017 Mar 1;16(1):31.
Title: Incretin-based agents in type 2 diabetic patients at cardiovascular risk: compare the effect of GLP-1 agonists and DPP-4 inhibitors on cardiovascular and pancreatic outcomes.
Author: Zhang, Zeqing|Chen, Xi|Lu, Puhan|Zhang, Jianhua|Xu, Yongping|He, Wentao|Li, Mengni|Zhang, Shujun|Jia, Jing|Shao, Shiying|Xie, Junhui|Yang, Yan|Yu, Xuefeng
PMID: 28249585
Journal: Lancet Diabetes Endocrinol. 2018 Feb;6(2):105-113.
Title: Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis.
Author: Bethel, M Angelyn|Patel, Rishi A|Merrill, Peter|Lokhnygina, Yuliya|Buse, John B|Mentz, Robert J|Pagidipati, Neha J|Chan, Juliana C|Gustavson, Stephanie M|Iqbal, Nayyar|Maggioni, Aldo P|Ohman, Peter|Poulter, Neil R|Ramachandran, Ambady|Zinman, Bernard|Hern
PMID: 29221659
Journal: Cancer Lett. 2018 Sep 1;431:190-200.
Title: Pancreatic cancer-derived exosomes suppress the production of GIP and GLP-1 from STC-1cells in vitro by down-regulating the PCSK1/3.
Author: Zhang, Yuefeng|Huang, Shifei|Li, Pengping|Chen, Qing|Li, Yongzhou|Zhou, Yizhao|Wang, Lantian|Kang, Muxing|Zhang, Bo|Yang, Bin|Dong, Xin|Wu, Yulian
PMID: 29800682
Journal: J Clin Endocrinol Metab. 2018 Apr 1;103(4):1296-1301.
Title: Recent Topics Around Multiple Endocrine Neoplasia Type 1.
Author: Marx, Stephen J
PMID: 29897580
Journal: Diabetes. 2018 Sep;67(9):1710-1719.
Title: The Ascending GLP-1 Road From Clinical Safety to Reduction of Cardiovascular Complications.
Author: Drucker, Daniel J
PMID: 30135132
Journal: Cochrane Database Syst Rev. 2018 Sep 24;9:CD011798.
Title: Insulin and glucose-lowering agents for treating people with diabetes and chronic kidney disease.
Author: Lo, Clement|Toyama, Tadashi|Wang, Ying|Lin, Jin|Hirakawa, Yoichiro|Jun, Min|Cass, Alan|Hawley, Carmel M|Pilmore, Helen|Badve, Sunil V|Perkovic, Vlado|Zoungas, Sophia
PMID: 30246878
Journal: Front Pharmacol. 2018 Sep 21;9:1071.
Title: Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling.
Author: Kim, Kang-Hoon|Lee, In-Seung|Park, Ji Young|Kim, Yumi|An, Eun-Jin|Jang, Hyeung-Jin
PMID: 30298009