Primary Site >> Biliary tract Cancer
Gene >> FGFR2
| 1. | |||||||||||
| Journal: | Hepatol Res. 2001 May 1;20(1):97-113. | ||||||||||
| Title: | Expression of angiogenic factors, basic fibroblast growth factor and vascular endothelial growth factor, in human biliary tract carcinoma cell lines. | ||||||||||
| Author: | Ogasawara, S|Yano, H|Higaki, K|Takayama, A|Akiba, J|Shiota, K|Kojiro, M | ||||||||||
| PMID: | 11282489 | ||||||||||
| 2. | |||||||||||
| Journal: | Anticancer Res. 2010 Oct;30(10):4115-21. | ||||||||||
| Title: | Significance of keratinocyte growth factor receptor in the proliferation of biliary tract cancer. | ||||||||||
| Author: | Amano, Ryosuke|Yamada, Nobuya|Doi, Yosuke|Yashiro, Masakazu|Ohira, Masaichi|Miwa, Atsushi|Hirakawa, Kosei | ||||||||||
| PMID: | 21036728 | ||||||||||
| 3. | |||||||||||
| Journal: | Hepatology. 2014 Apr;59(4):1427-34. | ||||||||||
| Title: | Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma. | ||||||||||
| Author: | Arai, Yasuhito|Totoki, Yasushi|Hosoda, Fumie|Shirota, Tomoki|Hama, Natsuko|Nakamura, Hiromi|Ojima, Hidenori|Furuta, Koh|Shimada, Kazuaki|Okusaka, Takuji|Kosuge, Tomoo|Shibata, Tatsuhiro | ||||||||||
| PMID: | 24122810 | ||||||||||
| 4. | |||||||||||
| Journal: | PLoS Genet. 2014 Feb 13;10(2):e1004135. | ||||||||||
| Title: | Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma. | ||||||||||
| Author: | Borad, Mitesh J|Champion, Mia D|Egan, Jan B|Liang, Winnie S|Fonseca, Rafael|Bryce, Alan H|McCullough, Ann E|Barrett, Michael T|Hunt, Katherine|Patel, Maitray D|Young, Scott W|Collins, Joseph M|Silva, Alvin C|Condjella, Rachel M|Block, Matthew|McWilliams, | ||||||||||
| PMID: | 24550739 | ||||||||||
| 5. | |||||||||||
| Journal: | Oncologist. 2014 Mar;19(3):235-42. | ||||||||||
| Title: | New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing. | ||||||||||
| Author: | Ross, Jeffrey S|Wang, Kai|Gay, Laurie|Al-Rohil, Rami|Rand, Janne V|Jones, David M|Lee, Hwa J|Sheehan, Christine E|Otto, Geoff A|Palmer, Gary|Yelensky, Roman|Lipson, Doron|Morosini, Deborah|Hawryluk, Matthew|Catenacci, Daniel V T|Miller, Vincent A|Churi, C | ||||||||||
| PMID: | 24563076 | ||||||||||
| 6. | |||||||||||
| Journal: | Hum Pathol. 2014 Aug;45(8):1630-8. | ||||||||||
| Title: | Fibroblast growth factor receptor 2 translocations in intrahepatic cholangiocarcinoma. | ||||||||||
| Author: | Graham, Rondell P|Barr Fritcher, Emily G|Pestova, Ekaterina|Schulz, John|Sitailo, Leonid A|Vasmatzis, George|Murphy, Stephen J|McWilliams, Robert R|Hart, Steven N|Halling, Kevin C|Roberts, Lewis R|Gores, Gregory J|Couch, Fergus J|Zhang, Lizhi|Borad, Mites | ||||||||||
| PMID: | 24837095 | ||||||||||
| 7. | |||||||||||
| Journal: | Nat Commun. 2015 Jan 22;6:6087. | ||||||||||
| Title: | Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma. | ||||||||||
| Author: | Sia, Daniela|Losic, Bojan|Moeini, Agrin|Cabellos, Laia|Hao, Ke|Revill, Kate|Bonal, Dennis|Miltiadous, Oriana|Zhang, Zhongyang|Hoshida, Yujin|Cornella, Helena|Castillo-Martin, Mireia|Pinyol, Roser|Kasai, Yumi|Roayaie, Sasan|Thung, Swan N|Fuster, Josep|Schw | ||||||||||
| PMID: | 25608663 | ||||||||||
| 8. | |||||||||||
| Journal: | J Gastroenterol Hepatol. 2015 Jul;30(7):1116-22. | ||||||||||
| Title: | Role of the fibroblast growth factor receptor axis in cholangiocarcinoma. | ||||||||||
| Author: | Ang, Celina | ||||||||||
| PMID: | 25678238 | ||||||||||
| 9. | |||||||||||
| Journal: | Curr Opin Gastroenterol. 2015 May;31(3):264-8. | ||||||||||
| Title: | Fibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinoma. | ||||||||||
| Author: | Borad, Mitesh J|Gores, Gregory J|Roberts, Lewis R | ||||||||||
| PMID: | 25763789 | ||||||||||
| 10. | |||||||||||
| Journal: | Nat Genet. 2015 Sep;47(9):1003-10. | ||||||||||
| Title: | Genomic spectra of biliary tract cancer. | ||||||||||
| Author: | Nakamura, Hiromi|Arai, Yasuhito|Totoki, Yasushi|Shirota, Tomoki|Elzawahry, Asmaa|Kato, Mamoru|Hama, Natsuko|Hosoda, Fumie|Urushidate, Tomoko|Ohashi, Shoko|Hiraoka, Nobuyoshi|Ojima, Hidenori|Shimada, Kazuaki|Okusaka, Takuji|Kosuge, Tomoo|Miyagawa, Shinichi | ||||||||||
| PMID: | 26258846 | ||||||||||
| 11. | |||||||||||
| Journal: | J Gastrointest Oncol. 2016 Oct;7(5):797-803. | ||||||||||
| Title: | Molecular profiling of biliary tract cancer: a target rich disease. | ||||||||||
| Author: | Jain, Apurva|Javle, Milind | ||||||||||
| PMID: | 27747093 | ||||||||||
| 12. | |||||||||||
| Journal: | Chin Clin Oncol. 2016 Oct;5(5):65. | ||||||||||
| Title: | Systemic therapy for biliary cancers. | ||||||||||
| Author: | Jordan, Emmet|Abou-Alfa, Ghassan K|Lowery, Maeve A | ||||||||||
| PMID: | 27829278 | ||||||||||
| 13. | |||||||||||
| Journal: | J Gastrointest Oncol. 2016 Oct;7(5):789-796. | ||||||||||
| Title: | The rise of the FGFR inhibitor in advanced biliary cancer: the next cover of time magazine? | ||||||||||
| Author: | Rizvi, Sumera|Borad, Mitesh J | ||||||||||
| PMID: | 27747092 | ||||||||||
| 14. | |||||||||||
| Journal: | PLoS One. 2016 Sep 14;11(9):e0162594. | ||||||||||
| Title: | Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation. | ||||||||||
| Author: | Hall, Terence G|Yu, Yi|Eathiraj, Sudharshan|Wang, Yunxia|Savage, Ronald E|Lapierre, Jean-Marc|Schwartz, Brian|Abbadessa, Giovanni | ||||||||||
| PMID: | 27627808 | ||||||||||
| 15. | |||||||||||
| Journal: | Cancer. 2016 Dec 15;122(24):3838-3847. | ||||||||||
| Title: | Biliary cancer: Utility of next-generation sequencing for clinical management. | ||||||||||
| Author: | Javle, Milind|Bekaii-Saab, Tanios|Jain, Apurva|Wang, Ying|Kelley, Robin Katie|Wang, Kai|Kang, Hyunseon C|Catenacci, Daniel|Ali, Siraj|Krishnan, Sunil|Ahn, Daniel|Bocobo, Andrea Grace|Zuo, Mingxin|Kaseb, Ahmed|Miller, Vincent|Stephens, Philip J|Meric-Berns | ||||||||||
| PMID: | 27622582 | ||||||||||
| 16. | |||||||||||
| Journal: | Cancer Lett. 2016 Sep 28;380(1):163-73. | ||||||||||
| Title: | Antitumor effect of FGFR inhibitors on a novel cholangiocarcinoma patient derived xenograft mouse model endogenously expressing an FGFR2-CCDC6 fusion protein. | ||||||||||
| Author: | Wang, Yu|Ding, Xiwei|Wang, Shaoqing|Moser, Catherine D|Shaleh, Hassan M|Mohamed, Essa A|Chaiteerakij, Roongruedee|Allotey, Loretta K|Chen, Gang|Miyabe, Katsuyuki|McNulty, Melissa S|Ndzengue, Albert|Barr Fritcher, Emily G|Knudson, Ryan A|Greipp, Patricia T | ||||||||||
| PMID: | 27216979 | ||||||||||
| 17. | |||||||||||
| Journal: | Oncotarget. 2016 Jul 19;7(29):46750-46767. | ||||||||||
| Title: | The landscape of targeted therapies for cholangiocarcinoma: current status and emerging targets. | ||||||||||
| Author: | Chong, Dawn Q|Zhu, Andrew X | ||||||||||
| PMID: | 27102149 | ||||||||||
| 18. | |||||||||||
| Journal: | J Clin Pathol. 2016 May;69(5):403-8. | ||||||||||
| Title: | Comprehensive genomic profiling of extrahepatic cholangiocarcinoma reveals a long tail of therapeutic targets. | ||||||||||
| Author: | Lee, Hwajeong|Wang, Kai|Johnson, Adrienne|Jones, David M|Ali, Siraj M|Elvin, Julia A|Yelensky, Roman|Lipson, Doron|Miller, Vincent A|Stephens, Philip J|Javle, Milind|Ross, Jeffrey S | ||||||||||
| PMID: | 26500333 | ||||||||||
| 19. | |||||||||||
| Journal: | Clin Cancer Res. 2016 Jan 15;22(2):291-300. | ||||||||||
| Title: | Molecular Pathogenesis and Targeted Therapies for Intrahepatic Cholangiocarcinoma. | ||||||||||
| Author: | Moeini, Agrin|Sia, Daniela|Bardeesy, Nabeel|Mazzaferro, Vincenzo|Llovet, Josep M | ||||||||||
| PMID: | 26405193 | ||||||||||
| 20. | |||||||||||
| Journal: | Am J Surg Pathol. 2016 Aug;40(8):1021-30. | ||||||||||
| Title: | Distinct Clinicopathologic and Genetic Features of 2 Histologic Subtypes of Intrahepatic Cholangiocarcinoma. | ||||||||||
| Author: | Hayashi, Akimasa|Misumi, Kento|Shibahara, Junji|Arita, Junichi|Sakamoto, Yoshihiro|Hasegawa, Kiyoshi|Kokudo, Norihiro|Fukayama, Masashi | ||||||||||
| PMID: | 27259014 | ||||||||||
| 21. | |||||||||||
| Journal: | Br J Cancer. 2017 Nov 21;117(11):1592-1599. | ||||||||||
| Title: | A Phase 1 study of ARQ 087, an oral pan-FGFR inhibitor in patients with advanced solid tumours. | ||||||||||
| Author: | Papadopoulos, K P|El-Rayes, B F|Tolcher, A W|Patnaik, A|Rasco, D W|Harvey, R D|LoRusso, P M|Sachdev, J C|Abbadessa, G|Savage, R E|Hall, T|Schwartz, B|Wang, Y|Kazakin, J|Shaib, W L | ||||||||||
| PMID: | 28972963 | ||||||||||
| 22. | |||||||||||
| Journal: | J Gastrointest Oncol. 2017 Jun;8(3):430-440. | ||||||||||
| Title: | Current biologics for treatment of biliary tract cancers. | ||||||||||
| Author: | Zhao, Diana Y|Lim, Kian-Huat | ||||||||||
| PMID: | 28736630 | ||||||||||
| 23. | |||||||||||
| Journal: | Therap Adv Gastroenterol. 2017 Jun;10(6):507-520. | ||||||||||
| Title: | The potential role of comprehensive genomic profiling to guide targeted therapy for patients with biliary cancer. | ||||||||||
| Author: | Lee, Hwajeong|Ross, Jeffrey S | ||||||||||
| PMID: | 28567120 | ||||||||||
| 24. | |||||||||||
| Journal: | Cancer Discov. 2017 Mar;7(3):248-249. | ||||||||||
| Title: | Gatekeeper Mutations and Intratumoral Heterogeneity in FGFR2-Translocated Cholangiocarcinoma. | ||||||||||
| Author: | Smyth, Elizabeth C|Babina, Irina S|Turner, Nicholas C | ||||||||||
| PMID: | 28264865 | ||||||||||
| 25. | |||||||||||
| Journal: | Gastroenterology. 2017 Mar;152(4):745-761. | ||||||||||
| Title: | Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis. | ||||||||||
| Author: | Sia, Daniela|Villanueva, Augusto|Friedman, Scott L|Llovet, Josep M | ||||||||||
| PMID: | 28043904 | ||||||||||
| 26. | |||||||||||
| Journal: | Cancer Discov. 2017 Mar;7(3):252-263. | ||||||||||
| Title: | Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma. | ||||||||||
| Author: | Goyal, Lipika|Saha, Supriya K|Liu, Leah Y|Siravegna, Giulia|Leshchiner, Ignaty|Ahronian, Leanne G|Lennerz, Jochen K|Vu, Phuong|Deshpande, Vikram|Kambadakone, Avinash|Mussolin, Benedetta|Reyes, Stephanie|Henderson, Laura|Sun, Jiaoyuan Elisabeth|Van Sevente | ||||||||||
| PMID: | 28034880 | ||||||||||
| 27. | |||||||||||
| Journal: | Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1454-1460. | ||||||||||
| Title: | Targeting cholangiocarcinoma. | ||||||||||
| Author: | Mertens, Joachim C|Rizvi, Sumera|Gores, Gregory J | ||||||||||
| PMID: | 28844952 | ||||||||||
| 28. | |||||||||||
| Journal: | J Clin Oncol. 2018 Jan 20;36(3):276-282. | ||||||||||
| Title: | Phase II Study of BGJ398 in Patients With FGFR-Altered Advanced Cholangiocarcinoma. | ||||||||||
| Author: | Javle, Milind|Lowery, Maeve|Shroff, Rachna T|Weiss, Karl Heinz|Springfeld, Christoph|Borad, Mitesh J|Ramanathan, Ramesh K|Goyal, Lipika|Sadeghi, Saeed|Macarulla, Teresa|El-Khoueiry, Anthony|Kelley, Robin Kate|Borbath, Ivan|Choo, Su Pin|Oh, Do-Youn|Philip, | ||||||||||
| PMID: | 29182496 | ||||||||||
| 29. | |||||||||||
| Journal: | Future Oncol. 2018 Mar;14(6):553-566. | ||||||||||
| Title: | Novel targeted therapy strategies for biliary tract cancers and hepatocellular carcinoma. | ||||||||||
| Author: | DeLeon, Thomas T|Ahn, Daniel H|Bogenberger, James M|Anastasiadis, Panos Z|Arora, Mansi|Ramanathan, Ramesh K|Aqel, Bashar A|Vasmatzis, George|Truty, Mark J|Oklu, Rahmi|Bekaii-Saab, Tanios S|Borad, Mitesh J | ||||||||||
| PMID: | 29460642 | ||||||||||
| 30. | |||||||||||
| Journal: | Hum Pathol. 2018 Jun;76:100-109. | ||||||||||
| Title: | Low-level clonal FGFR2 amplification defines a unique molecular subtype of intrahepatic cholangiocarcinoma in a Chinese population. | ||||||||||
| Author: | Pu, Xiao-Hong|Ye, Qing|Yang, Jun|Wu, Hong-Yan|Ding, Xi-Wei|Shi, Jiong|Mao, Liang|Fan, Xiang-Shan|Chen, Jun|Qiu, Yu-Dong|Huang, Qin | ||||||||||
| PMID: | 29514108 | ||||||||||
| 31. | |||||||||||
| Journal: | Cancer Sci. 2018 May;109(5):1282-1291. | ||||||||||
| Title: | Molecular genomic landscapes of hepatobiliary cancer. | ||||||||||
| Author: | Shibata, Tatsuhiro|Arai, Yasuhito|Totoki, Yasushi | ||||||||||
| PMID: | 29573058 | ||||||||||
| 32. | |||||||||||
| Journal: | Clin Cancer Res. 2018 Sep 1;24(17):4154-4161. | ||||||||||
| Title: | Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for Intervention. | ||||||||||
| Author: | Lowery, Maeve A|Ptashkin, Ryan|Jordan, Emmet|Berger, Michael F|Zehir, Ahmet|Capanu, Marinela|Kemeny, Nancy E|O'Reilly, Eileen M|El-Dika, Imane|Jarnagin, William R|Harding, James J|D'Angelica, Michael I|Cercek, Andrea|Hechtman, Jaclyn F|Solit, David B|Schu | ||||||||||
| PMID: | 29848569 | ||||||||||
| 33. | |||||||||||
| Journal: | Jpn J Clin Oncol. 2018 Aug 1;48(8):703-711. | ||||||||||
| Title: | New developments in systemic therapy for advanced biliary tract cancer. | ||||||||||
| Author: | Morizane, Chigusa|Ueno, Makoto|Ikeda, Masafumi|Okusaka, Takuji|Ishii, Hiroshi|Furuse, Junji | ||||||||||
| PMID: | 29893894 | ||||||||||
| 34. | |||||||||||
| Journal: | Hepatology. 2018 Aug 1. | ||||||||||
| Title: | HSP90 inhibition drives degradation of FGFR2 fusion proteins: implications for treatment of cholangiocarcinoma. | ||||||||||
| Author: | Lamberti, Dante|Cristinziano, Giulia|Porru, Manuela|Leonetti, Carlo|Egan, Jan B|Shi, Chang-Xin|Buglioni, Simonetta|Amoreo, Carla A|Castellani, Loriana|Borad, Mitesh J|Alema, Stefano|Anastasi, Sergio|Segatto, Oreste | ||||||||||
| PMID: | 30067876 | ||||||||||
| 35. | |||||||||||
| Journal: | Front Genet. 2018 Aug 15;9:309. | ||||||||||
| Title: | Emergence of Intrahepatic Cholangiocarcinoma: How High-Throughput Technologies Expedite the Solutions for a Rare Cancer Type. | ||||||||||
| Author: | Shiao, Meng-Shin|Chiablaem, Khajeelak|Charoensawan, Varodom|Ngamphaiboon, Nuttapong|Jinawath, Natini | ||||||||||
| PMID: | 30158952 | ||||||||||
| 36. | |||||||||||
| Journal: | J Cell Mol Med. 2018 Aug 30. | ||||||||||
| Title: | Sprouty2 suppresses progression and correlates to favourable prognosis of intrahepatic cholangiocarcinoma via antagonizing FGFR2 signalling. | ||||||||||
| Author: | Xu, Yun-Fei|Liu, Hong-Da|Liu, Zeng-Li|Pan, Chang|Yang, Xiao-Qing|Ning, Shang-Lei|Zhang, Zong-Li|Guo, Sen|Yu, Jin-Ming | ||||||||||
| PMID: | 30160357 | ||||||||||