Primary Site >> Pancreatic Cancer

Gene >> ERBB3

Journal: J Mol Med (Berl). 1996 Jan;74(1):35-42.
Title: Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors.
Author: Friess, H|Berberat, P|Schilling, M|Kunz, J|Korc, M|Buchler, M W
PMID: 8834768
Journal: Ann Surg. 1999 Dec;230(6):767-74; discussion 774-5.
Title: Growth factor receptors are differentially expressed in cancers of the papilla of vater and pancreas.
Author: Friess, H|Wang, L|Zhu, Z|Gerber, R|Schroder, M|Fukuda, A|Zimmermann, A|Korc, M|Buchler, M W
PMID: 10615931
Journal: J Gastrointest Surg. 2004 Dec;8(8):960-9; discussion 969-70.
Title: Mechanisms of resistance to Erbitux (anti-epidermal growth factor receptor) combination therapy in pancreatic adenocarcinoma cells.
Author: Arnoletti, J Pablo|Buchsbaum, Donald J|Huang, Zhi-qiang|Hawkins, Ashley E|Khazaeli, Muhamad B|Kraus, Matthias H|Vickers, Selwyn M
PMID: 15585383
Journal:
Title: [(11)C]N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine
Author: Shan, Liang
PMID: 20641864
Journal: Cancer Res. 2006 Jan 15;66(2):1025-32.
Title: Antitumor activity of epidermal growth factor receptor-related protein is mediated by inactivation of ErbB receptors and nuclear factor-kappaB in pancreatic cancer.
Author: Zhang, Yuxiang|Banerjee, Sanjeev|Wang, Zhiwei|Xu, Hu|Zhang, Liyue|Mohammad, Ramzi|Aboukameel, Amro|Adsay, Nazmi V|Che, Mingxin|Abbruzzese, James L|Majumdar, Adhip P N|Sarkar, Fazlul H
PMID: 16424038
Journal: Int J Cancer. 2007 Feb 1;120(3):514-23.
Title: Expression and differential signaling of heregulins in pancreatic cancer cells.
Author: Kolb, Armin|Kleeff, Jorg|Arnold, Nichole|Giese, Nathalia A|Giese, Thomas|Korc, Murray|Friess, Helmut
PMID: 17096356
Journal: Cancer Biol Ther. 2007 Apr;6(4):548-54.
Title: ErbB3 expression and dimerization with EGFR influence pancreatic cancer cell sensitivity to erlotinib.
Author: Frolov, Andrey|Schuller, Kyle|Tzeng, Ching-Wei D|Cannon, Emily E|Ku, Brandon C|Howard, J Harrison|Vickers, Selwyn M|Heslin, Martin J|Buchsbaum, Donald J|Arnoletti, J Pablo
PMID: 17457047
Journal: Cancer Res. 2007 Aug 1;67(15):7256-65.
Title: Epidermal growth factor receptor tyrosine phosphorylation and signaling controlled by a nuclear receptor coactivator, amplified in breast cancer 1.
Author: Lahusen, Tyler|Fereshteh, Mark|Oh, Annabell|Wellstein, Anton|Riegel, Anna T
PMID: 17671194
Journal: Eur J Surg Oncol. 2009 Oct;35(10):1098-104.
Title: HER-family gene amplification and expression in resected pancreatic cancer.
Author: te Velde, E A|Franke, A C|van Hillegersberg, R|Elshof, S M|de Weger, R W|Borel Rinkes, I H M|van Diest, P J
PMID: 19304440
Journal: Cancer Sci. 2010 Nov;101(11):2351-60.
Title: Amphiregulin regulates the activation of ERK and Akt through epidermal growth factor receptor and HER3 signals involved in the progression of pancreatic cancer.
Author: Yotsumoto, Fusanori|Fukami, Tatsuya|Yagi, Hiroshi|Funakoshi, Akihiro|Yoshizato, Toshiyuki|Kuroki, Masahide|Miyamoto, Shingo
PMID: 20726858
Journal: Cancer Biol Ther. 2010 Sep 15;10(6):555-63. Epub 2010 Sep 30.
Title: ErbB3 expression promotes tumorigenesis in pancreatic adenocarcinoma.
Author: Liles, J Spencer|Arnoletti, Juan Pablo|Tzeng, Ching-Wei D|Howard, J Harrison|Kossenkov, Andrew V|Kulesza, Peter|Heslin, Martin J|Frolov, Andrey
PMID: 20647770
Journal: Clin Cancer Res. 2010 Feb 1;16(3):912-23.
Title: Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status.
Author: Kimple, Randall J|Vaseva, Angelina V|Cox, Adrienne D|Baerman, Kathryn M|Calvo, Benjamin F|Tepper, Joel E|Shields, Janiel M|Sartor, Carolyn I
PMID: 20103665
Journal: Exp Cell Res. 2011 Feb 15;317(4):392-404.
Title: Ligand stimulation of ErbB4 and a constitutively-active ErbB4 mutant result in different biological responses in human pancreatic tumor cell lines.
Author: Mill, Christopher P|Gettinger, Kathleen L|Riese, David J 2nd
PMID: 21110957
Journal: Br J Cancer. 2011 Aug 9;105(4):523-33.
Title: Targeting ErbB3-mediated stromal-epithelial interactions in pancreatic ductal adenocarcinoma.
Author: Liles, J S|Arnoletti, J P|Kossenkov, A V|Mikhaylina, A|Frost, A R|Kulesza, P|Heslin, M J|Frolov, A
PMID: 21792199
Journal: Oncology. 2011;81(3-4):192-8.
Title: HER3 overexpression as an independent indicator of poor prognosis for patients with curatively resected pancreatic cancer.
Author: Hirakawa, Toshiki|Nakata, Bunzo|Amano, Ryosuke|Kimura, Kenjiro|Shimizu, Sadatoshi|Ohira, Go|Yamada, Nobuya|Ohira, Masaichi|Hirakawa, Kosei
PMID: 22067729
Journal: Exp Ther Med. 2011 Sep;2(5):969-975.
Title: Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in BXPC-3 and PANC-1 human pancreatic cancer cells.
Author: Wang, Lin|Zhu, Zhi-Xia|Zhang, Wen-Ying|Zhang, Wei-Min
PMID: 22977607
Journal: J Cell Physiol. 2012 Oct;227(10):3381-8.
Title: Novel anti-ErbB3 monoclonal antibodies show therapeutic efficacy in xenografted and spontaneous mouse tumors.
Author: Aurisicchio, Luigi|Marra, Emanuele|Luberto, Laura|Carlomosti, Fabrizio|De Vitis, Claudia|Noto, Alessia|Gunes, Zeynep|Roscilli, Giuseppe|Mesiti, Giuseppe|Mancini, Rita|Alimandi, Maurizio|Ciliberto, Gennaro
PMID: 22213458
Journal: PLoS One. 2012;7(2):e32232.
Title: The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways.
Author: Jonckheere, Nicolas|Skrypek, Nicolas|Merlin, Johann|Dessein, Anne Frederique|Dumont, Patrick|Leteurtre, Emmanuelle|Harris, Ann|Desseyn, Jean-Luc|Susini, Christiane|Frenois, Frederic|Van Seuningen, Isabelle
PMID: 22393391
Journal: Curr Drug Targets. 2012 Jun;13(6):802-10.
Title: Targeting EGFR in pancreatic cancer treatment.
Author: Troiani, T|Martinelli, E|Capasso, A|Morgillo, F|Orditura, Michele|De Vita, F|Ciardiello, F
PMID: 22458527
Journal: PLoS One. 2012;7(6):e39684.
Title: Concomitant targeting of EGF receptor, TGF-beta and SRC points to a novel therapeutic approach in pancreatic cancer.
Author: Deharvengt, Sophie|Marmarelis, Melina|Korc, Murray
PMID: 22761868
Journal: J Cancer Res Ther Oncol. 2013 Aug 22;1(1):10.
Title: Multiple Functional Motifs Are Required for the Tumor Suppressor Activity of a Constitutively-Active ErbB4 Mutant.
Author: Gallo, Richard M|Bryant, Ianthe N|Mill, Christopher P|Kaverman, Steven|Riese, David J 2nd
PMID: 24791013
Journal: Mol Cancer Ther. 2013 Oct;12(10):2213-25.
Title: Subtype-specific MEK-PI3 kinase feedback as a therapeutic target in pancreatic adenocarcinoma.
Author: Mirzoeva, Olga K|Collisson, Eric A|Schaefer, Peter M|Hann, Byron|Hom, Yun K|Ko, Andrew H|Korn, W Michael
PMID: 23918833
Journal: J Natl Cancer Inst. 2013 Feb 20;105(4):266-73.
Title: HER3 overexpression and survival in solid tumors: a meta-analysis.
Author: Ocana, Alberto|Vera-Badillo, Francisco|Seruga, Bostjan|Templeton, Arnoud|Pandiella, Atanasio|Amir, Eitan
PMID: 23221996
Journal: PLoS One. 2013;8(1):e53645.
Title: Epithelial-mesenchymal transition markers and HER3 expression are predictors of elisidepsin treatment response in breast and pancreatic cancer cell lines.
Author: Teixido, Cristina|Mares, Roso|Aracil, Miguel|Ramon y Cajal, Santiago|Hernandez-Losa, Javier
PMID: 23320098
Journal: Pharmacol Res. 2014 Jan;79:34-74.
Title: The ErbB/HER family of protein-tyrosine kinases and cancer.
Author: Roskoski, Robert Jr
PMID: 24269963
Journal: Exp Cell Res. 2014 Aug 15;326(2):307-14.
Title: Induction of pancreatic cancer cell migration by an autocrine epidermal growth factor receptor activation.
Author: Stock, Anna-Maria|Hahn, Stephan A|Troost, Gabriele|Niggemann, Bernd|Zanker, Kurt S|Entschladen, Frank
PMID: 24810090
Journal: Oncogenesis. 2014 Aug 18;3:e117.
Title: Dual targeting of ErbB-2/ErbB-3 results in enhanced antitumor activity in preclinical models of pancreatic cancer.
Author: Ghasemi, R|Rapposelli, I G|Capone, E|Rossi, C|Lattanzio, R|Piantelli, M|Sala, G|Iacobelli, S
PMID: 25133484
Journal: Oncotarget. 2014 Aug 30;5(16):7138-48.
Title: HER3 as biomarker and therapeutic target in pancreatic cancer: new insights in pertuzumab therapy in preclinical models.
Author: Thomas, Gaelle|Chardes, Thierry|Gaborit, Nadege|Mollevi, Caroline|Leconet, Wilhem|Robert, Bruno|Radosevic-Robin, Nina|Penault-Llorca, Frederique|Gongora, Celine|Colombo, Pierre-Emmanuel|Lazrek, Yassamine|Bras-Goncalves, Rui|Savina, Ariel|Azria, David|Bazi
PMID: 25216528
Journal: Oncoimmunology. 2014 Dec 21;3(11):e956012.
Title: HER-3 peptide vaccines/mimics: Combined therapy with IGF-1R, HER-2, and HER-1 peptides induces synergistic antitumor effects against breast and pancreatic cancer cells.
Author: Miller, Megan Jo|Foy, Kevin C|Overholser, Jay P|Nahta, Rita|Kaumaya, Pravin Tp
PMID: 25941588
Journal: Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):839-44.
Title: Examination of HER3 targeting in cancer using monoclonal antibodies.
Author: Gaborit, Nadege|Abdul-Hai, Ali|Mancini, Maicol|Lindzen, Moshit|Lavi, Sara|Leitner, Orith|Mounier, Lucile|Chentouf, Myriam|Dunoyer, Sai|Ghosh, Manjusha|Larbouret, Christel|Chardes, Thierry|Bazin, Herve|Pelegrin, Andre|Sela, Michael|Yarden, Yosef
PMID: 25564668
Journal: Oncotarget. 2015 Aug 21;6(24):20132-44.
Title: Combined targeting of EGFR/HER promotes anti-tumor efficacy in subsets of KRAS mutant lung cancer resistant to single EGFR blockade.
Author: Umelo, Ijeoma Adaku|De Wever, Olivier|Kronenberger, Peter|Van Deun, Jan|Noor, Alfiah|Singh, Kshitiz|Teugels, Erik|Chen, Gang|Bracke, Marc|De Greve, Jacques
PMID: 25992771
Journal: Oncotarget. 2015 Aug 28;6(25):21085-99.
Title: Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells.
Author: Lakshmanan, Imayavaramban|Seshacharyulu, Parthasarathy|Haridas, Dhanya|Rachagani, Satyanarayana|Gupta, Suprit|Joshi, Suhasini|Guda, Chittibabu|Yan, Ying|Jain, Maneesh|Ganti, Apar K|Ponnusamy, Moorthy P|Batra, Surinder K
PMID: 26035354
Journal: Int J Mol Sci. 2015 Aug 17;16(8):19447-57.
Title: Pyrosequencing-Based Assays for Rapid Detection of HER2 and HER3 Mutations in Clinical Samples Uncover an E332E Mutation Affecting HER3 in Retroperitoneal Leiomyosarcoma.
Author: Gonzalez-Alonso, Paula|Chamizo, Cristina|Moreno, Victor|Madoz-Gurpide, Juan|Carvajal, Nerea|Daoud, Lina|Zazo, Sandra|Martin-Aparicio, Ester|Cristobal, Ion|Rincon, Raul|Garcia-Foncillas, Jesus|Rojo, Federico
PMID: 26287187
Journal: Carcinogenesis. 2015 Dec;36(12):1580-9.
Title: The retinoic acid derivative, ABPN, inhibits pancreatic cancer through induction of Nrdp1.
Author: Byun, Sanguine|Shin, Seung Ho|Lee, Eunjung|Lee, Jihoon|Lee, Sung-Young|Farrand, Lee|Jung, Sung Keun|Cho, Yong-Yeon|Um, Soo-Jong|Sin, Hong-Sig|Kwon, Youn-Ja|Zhang, Chengjuan|Tsang, Benjamin K|Bode, Ann M|Lee, Hyong Joo|Lee, Ki Won|Dong, Zigang
PMID: 26464195
Journal: Expert Opin Biol Ther. 2016;16(2):243-53.
Title: Pertuzumab in gastrointestinal cancer.
Author: Oh, Do-Youn|Bang, Yung-Jue
PMID: 26619359
Journal: BMC Cancer. 2016 Nov 21;16(1):910.
Title: The prognostic significance of human epidermal growth factor receptor family protein expression in operable pancreatic cancer : HER1-4 protein expression and prognosis in pancreatic cancer.
Author: Li, Qin|Zhang, Lei|Li, XiuHong|Yan, Han|Yang, Liuting|Li, Yingying|Li, Teng|Wang, Jing|Cao, Bangwei
PMID: 27871278
Journal: Pancreas. 2016 Oct;45(9):1263-1271.
Title: MicroRNA-148a Suppresses the Proliferation and Migration of Pancreatic Cancer Cells by Down-regulating ErbB3.
Author: Feng, Hui|Wang, Yalei|Su, Jiaojiao|Liang, Hongwei|Zhang, Chen-Yu|Chen, Xi|Yao, Weiyan
PMID: 27776045
Journal: Expert Opin Biol Ther. 2016 Dec;16(12):1549-1555.
Title: The prospect of patritumab for treating non-small cell lung cancer.
Author: Horinouchi, Hidehito
PMID: 27744717
Journal: Sci Rep. 2016 Sep 9;6:32809.
Title: Paeoniflorin Potentiates the Inhibitory Effects of Erlotinib in Pancreatic Cancer Cell Lines by Reducing ErbB3 Phosphorylation.
Author: Hao, Jian|Yang, Xue|Ding, Xiu-Li|Guo, Lei-Ming|Zhu, Cui-Hong|Ji, Wei|Zhou, Tong|Wu, Xiong-Zhi
PMID: 27609096
Journal: PLoS One. 2016 Apr 12;11(4):e0153533.
Title: Expression and Prognostic Significance of Human Epidermal Growth Factor Receptors 1, 2 and 3 in Periampullary Adenocarcinoma.
Author: Elebro, Jacob|Heby, Margareta|Warfvinge, Carl Fredrik|Nodin, Bjorn|Eberhard, Jakob|Jirstrom, Karin
PMID: 27070783
Journal: Target Oncol. 2016 Jun;11(3):371-81.
Title: Afatinib, an Irreversible EGFR Family Inhibitor, Shows Activity Toward Pancreatic Cancer Cells, Alone and in Combination with Radiotherapy, Independent of KRAS Status.
Author: Huguet, Florence|Fernet, Marie|Giocanti, Nicole|Favaudon, Vincent|Larsen, Annette K
PMID: 26668065
Journal: Mol Cancer Ther. 2017 Jul;16(7):1312-1323.
Title: Neuregulin 1 Allosterically Enhances the Antitumor Effects of the Noncompeting Anti-HER3 Antibody 9F7-F11 by Increasing Its Binding to HER3.
Author: Le Clorennec, Christophe|Bazin, Herve|Dubreuil, Olivier|Larbouret, Christel|Ogier, Charline|Lazrek, Yassamine|Garambois, Veronique|Poul, Marie-Alix|Mondon, Philippe|Barret, Jean-Marc|Mathis, Gerard|Prost, Jean-Francois|Pelegrin, Andre|Chardes, Thierry
PMID: 28507002
Journal: Clin Cancer Res. 2018 Jun 15;24(12):2873-2885.
Title: Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer.
Author: Camblin, Adam J|Pace, Emily A|Adams, Sharlene|Curley, Michael D|Rimkunas, Victoria|Nie, Lin|Tan, Gege|Bloom, Troy|Iadevaia, Sergio|Baum, Jason|Minx, Charlene|Czibere, Akos|Louis, Chrystal U|Drummond, Daryl C|Nielsen, Ulrik B|Schoeberl, Birgit|Pipas, J Mar
PMID: 29549161
Journal: Sci Rep. 2018 Jun 13;8(1):9043.
Title: Imaging EGFR and HER3 through (89)Zr-labeled MEHD7945A (Duligotuzumab).
Author: McKnight, Brooke N|Kuda-Wedagedara, Akhila N W|Sevak, Kuntal K|Abdel-Atti, Dalya|Wiesend, Wendy N|Ku, Anson|Selvakumar, Dakshnamurthy|Carlin, Sean D|Lewis, Jason S|Viola-Villegas, Nerissa T
PMID: 29899472
Journal: Cancer Lett. 2018 Sep 28;432:227-236.
Title: Targeting the NRG1/HER3 pathway in tumor cells and cancer-associated fibroblasts with an anti-neuregulin 1 antibody inhibits tumor growth in pre-clinical models of pancreatic cancer.
Author: Ogier, Charline|Colombo, Pierre-Emmanuel|Bousquet, Corinne|Canterel-Thouennon, Lucile|Sicard, Pierre|Garambois, Veronique|Thomas, Gaelle|Gaborit, Nadege|Jarlier, Marta|Pirot, Nelly|Pugniere, Martine|Vie, Nadia|Gongora, Celine|Martineau, Pierre|Robert, Bru
PMID: 29935372
Journal: Toxins (Basel). 2018 Oct 31;10(11). pii: toxins10110447.
Title: Protein Synthesis Inhibition Activity of Mesothelin Targeting Immunotoxin LMB-100 Decreases Concentrations of Oncogenic Signaling Molecules and Secreted Growth Factors.
Author: El-Behaedi, Salma|Landsman, Rebekah|Rudloff, Michael|Kolyvas, Emily|Albalawy, Rakan|Zhang, Xianyu|Bera, Tapan|Collins, Keith|Kozlov, Serguei|Alewine, Christine
PMID: 30384408