Primary Site >> Biliary tract Cancer

Gene >> EPHB2

Journal: Gut. 2003 May;52(5):706-12.
Title: Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma.
Author: Tannapfel, A|Sommerer, F|Benicke, M|Katalinic, A|Uhlmann, D|Witzigmann, H|Hauss, J|Wittekind, C
PMID: 12692057
Journal: Int J Oncol. 2006 Apr;28(4):915-21.
Title: The effects of ZD1839 (Iressa), a highly selective EGFR tyrosine kinase inhibitor, as a radiosensitiser in bile duct carcinoma cell lines.
Author: Miyata, Hideki|Sasaki, Tamito|Kuwahara, Kenichi|Serikawa, Masahiro|Chayama, Kazuaki
PMID: 16525641
Journal: J Surg Res. 2006 Nov;136(1):78-84. Epub 2006 Sep 1.
Title: Involvement of c-Met/hepatocyte growth factor pathway in cholangiocarcinoma cell invasion and its therapeutic inhibition with small interfering RNA specific for c-Met.
Author: Leelawat, Kawin|Leelawat, Surang|Tepaksorn, Panada|Rattanasinganchan, Panthip|Leungchaweng, Anicha|Tohtong, Rutaiwan|Sobhon, Prasert
PMID: 16950403
Journal: J Clin Invest. 2006 Jul;116(7):1843-52. Epub 2006 Jun 8.
Title: Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.
Author: Xu, Xiaoling|Kobayashi, Shogo|Qiao, Wenhui|Li, Cuiling|Xiao, Cuiying|Radaeva, Svetlana|Stiles, Bangyan|Wang, Rui-Hong|Ohara, Nobuya|Yoshino, Tadashi|LeRoith, Derek|Torbenson, Michael S|Gores, Gregory J|Wu, Hong|Gao, Bin|Deng, Chu-Xia
PMID: 16767220
Journal: Mol Cell Biochem. 2007 Nov;305(1-2):19-26. Epub 2007 Jun 6.
Title: Prostaglandin E2 enhances mitogen-activated protein kinase/Erk pathway in human cholangiocarcinoma cells: involvement of EP1 receptor, calcium and EGF receptors signaling.
Author: Zhang, Li|Jiang, Li|Sun, Qiuyan|Peng, Tao|Lou, Kexin|Liu, Ningbo|Leng, Jing
PMID: 17551669
Journal: Hepatogastroenterology. 2007 Jul-Aug;54(77):1339-44.
Title: Intestinal trefoil factor (TFF-3) and extracellular signal-regulated kinase (ERK) in cholangiocarcinoma.
Author: Ailawadhi, Sikander|Nagase, Hiroki|Khoury, Thaer|Yu, Jihnhee|Tan, Dongfeng|Black, Jennifer|Brattain, Michael|Javle, Milind
PMID: 17708250
Journal: J Exp Clin Cancer Res. 2009 May 18;28:65.
Title: Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations.
Author: Li, Qinglong|Yang, Zhulin
PMID: 19445727
Journal: Dig Dis Sci. 2010 Oct;55(10):2844-52.
Title: The role of MAPK-ERK pathway in 67-kDa laminin receptor-induced FasL expression in human cholangiocarcinoma cells.
Author: Duan, Shi-Gang|Cheng, Long|Li, Da-Jiang|Zhu, Jin|Xiong, Yan|Li, Xiao-Wu|Wang, Shu-Guang
PMID: 20101459
Journal: Curr Drug Targets. 2010 Jul;11(7):834-50.
Title: Molecular targeted therapy of biliary tract cancer--results of the first clinical studies.
Author: Wiedmann, Marcus W|Mossner, Joachim
PMID: 20388063
Journal: J Gastroenterol. 2011 May;46(5):664-75.
Title: Downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) is associated with enhanced expression of matrix metalloproteinases and cholangiocarcinoma metastases.
Author: Namwat, N|Puetkasichonpasutha, J|Loilome, W|Yongvanit, P|Techasen, A|Puapairoj, A|Sripa, B|Tassaneeyakul, W|Khuntikeo, N|Wongkham, S
PMID: 21076843
Journal: Cancer Sci. 2012 Feb;103(2):252-61.
Title: Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers.
Author: Ohashi, Hirokazu|Adachi, Yasushi|Yamamoto, Hiroyuki|Taniguchi, Hiroaki|Nosho, Katsuhiko|Suzuki, Hiromu|Arimura, Yoshiaki|Imai, Kohzoh|Carbone, David P|Shinomura, Yasuhisa
PMID: 22044563
Journal: Cancer Lett. 2012 Mar;316(1):70-6.
Title: L1 cell adhesion molecule and epidermal growth factor receptor activation confer cisplatin resistance in intrahepatic cholangiocarcinoma cells.
Author: Yoon, Hyunho|Min, Jeong-Ki|Lee, Dong Gwang|Kim, Dae-Ghon|Koh, Sang Seok|Hong, Hyo Jeong
PMID: 22088438
Journal: J Hepatol. 2012 Oct;57(4):813-20.
Title: Role of the stromal-derived factor-1 (SDF-1)-CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma.
Author: Gentilini, Alessandra|Rombouts, Krista|Galastri, Sara|Caligiuri, Alessandra|Mingarelli, Eleonora|Mello, Tommaso|Marra, Fabio|Mantero, Stefano|Roncalli, Massimo|Invernizzi, Pietro|Pinzani, Massimo
PMID: 22727731
Journal: Int J Oncol. 2013 Feb;42(2):690-8.
Title: Genetic and epigenetic alterations are involved in the regulation of TPM1 in cholangiocarcinoma.
Author: Yang, Wei|Wang, Xiaoyuan|Zheng, Wei|Li, Kedong|Liu, Haofeng|Sun, Yueming
PMID: 23254774
Journal: ISRN Hepatol. 2013 Nov 17;2013:601071.
Title: Protective Effects of Guava Pulp on Cholestatic Liver Injury.
Author: Peng, Jian|Yue, Chunyan|Qiu, Kai|Chen, Jie|Aller, Maria-Angeles|Ko, Kwang Suk|Yang, Heping
PMID: 27335829
Journal: J Pathol. 2013 Jun;230(2):165-73.
Title: PTEN loss and KRAS activation cooperate in murine biliary tract malignancies.
Author: Marsh, Victoria|Davies, Emma J|Williams, Geraint T|Clarke, Alan R
PMID: 23483557
Journal: Oncol Rep. 2014 Jan;31(1):145-52.
Title: Hydroxytyrosol inhibits cholangiocarcinoma tumor growth: an in vivo and in vitro study.
Author: Li, Shuai|Han, Zhiyang|Ma, Yong|Song, Ruipeng|Pei, Tiemin|Zheng, Tongsen|Wang, Jiabei|Xu, Dongsheng|Fang, Xiang|Jiang, Hongchi|Liu, Lianxin
PMID: 24247752
Journal: Int J Clin Exp Pathol. 2014 Jan 15;7(2):521-8. eCollection 2014.
Title: Potential biomarkers for sensitivity of gallbladder cancer cells to gemcitabine.
Author: Yang, Chao|Xu, Ming|Shen, Huo-Jian|Zhu, Hong-Yi|Li, Fu|He, Min|Chen, Tao|Wang, Jian|Shi, Wei-Jin|Ji, Fu
PMID: 24551272
Journal: Oncol Rep. 2014 Jun;31(6):2611-8.
Title: Metformin inhibits proliferation and enhances chemosensitivity of intrahepatic cholangiocarcinoma cell lines.
Author: Ling, Sunbin|Feng, Tingting|Ke, Qinghong|Fan, Ning|Li, Lei|Li, Zhongxing|Dong, Chengyong|Wang, Cong|Xu, Fei|Li, Yan|Wang, Liming
PMID: 24788596
Journal: Tumour Biol. 2014 Oct;35(10):10031-41.
Title: Increased EphB2 expression predicts cholangiocarcinoma metastasis.
Author: Khansaard, Walaiporn|Techasen, Anchalee|Namwat, Nisana|Yongvanit, Puangrat|Khuntikeo, Narong|Puapairoj, Anucha|Loilome, Watcharin
PMID: 25012246
Journal: Invest New Drugs. 2014 Dec;32(6):1144-54.
Title: Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors.
Author: Ewald, Florian|Norz, Dominik|Grottke, Astrid|Hofmann, Bianca T|Nashan, Bjorn|Jucker, Manfred
PMID: 25152244
Journal: J Liver. 2014 Jul;3(3).
Title: Fibroblast Growth Factor 19 Activates the Unfolded Protein Response and Mitogen-Activated Protein Kinase Phosphorylation in H-69 Cholangiocyte Cells.
Author: Qureshi, Hannan A|Pearl, Jeffrey A|Anderson, Kristy A|Green, Richard M
PMID: 29093991
Journal: Int J Clin Exp Med. 2015 Oct 15;8(10):17781-8. eCollection 2015.
Title: Pachymic acid inhibits tumorigenesis in gallbladder carcinoma cells.
Author: Chen, Yueguang|Lian, Peilong|Liu, Yanfeng|Xu, Kesen
PMID: 26770369
Journal: Tumour Biol. 2015 Jul;36(7):5171-7.
Title: Loss of angiotensin-converting enzyme 2 promotes growth of gallbladder cancer.
Author: Zong, Huajie|Yin, Baobing|Zhou, Huading|Cai, Duan|Ma, Baojin|Xiang, Yang
PMID: 25663464
Journal: Oncotarget. 2015 Sep 15;6(27):23594-608.
Title: Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma.
Author: Chen, Ming-Huang|Yen, Chueh-Chuan|Cheng, Chi-Tung|Wu, Ren-Chin|Huang, Shih-Chiang|Yu, Chung-Shan|Chung, Yi-Hsiu|Liu, Chun-Yu|Chang, Peter Mu-Hsin|Chao, Yee|Chen, Ming-Han|Chen, Yu-Fen|Chiang, Kun-Chun|Yeh, Ta-Sen|Chen, Tzu Chi|Huang, Chi-Ying F|Yeh, Chun-
PMID: 26090720
Journal: Gut Liver. 2016 Mar;10(2):310-7.
Title: Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells.
Author: Lee, Jin|Hong, Eun Mi|Jang, Ju Ah|Park, Se Woo|Koh, Dong Hee|Choi, Min Ho|Jang, Hyun Joo|Kae, Sea Hyub
PMID: 26470769
Journal: J Gastroenterol. 2016 Jul;51(7):711-21.
Title: A potent therapeutics for gallbladder cancer by combinatorial inhibition of the MAPK and mTOR signaling networks.
Author: Mohri, Dai|Ijichi, Hideaki|Miyabayashi, Koji|Takahashi, Ryota|Kudo, Yotaro|Sasaki, Takashi|Asaoka, Yoshinari|Tanaka, Yasuo|Ikenoue, Tsuneo|Tateishi, Keisuke|Tada, Minoru|Isayama, Hiroyuki|Koike, Kazuhiko
PMID: 26614007
Journal: Cell Mol Neurobiol. 2016 Oct;36(7):1097-107.
Title: Downregulation of lncRNA-MALAT1 Affects Proliferation and the Expression of Stemness Markers in Glioma Stem Cell Line SHG139S.
Author: Han, Yong|Zhou, Liang|Wu, Tingfeng|Huang, Yulun|Cheng, Zhe|Li, Xuetao|Sun, Ting|Zhou, Youxin|Du, Ziwei
PMID: 26649728
Journal: Oncotarget. 2016 Feb 2;7(5):5306-12.
Title: Whole-exome tumor sequencing study in biliary cancer patients with a response to MEK inhibitors.
Author: Ahn, Daniel H|Ozer, Hatice Gulcin|Hancioglu, Baris|Lesinski, Gregory B|Timmers, Cynthia|Bekaii-Saab, Tanios
PMID: 26683364
Journal: World J Gastroenterol. 2016 Feb 14;22(6):2071-80.
Title: Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice.
Author: Ding, Ning|Che, Li|Li, Xiao-Lei|Liu, Yan|Jiang, Li-Jie|Fan, Biao|Tao, Jun-Yan|Chen, Xin|Ji, Jia-Fu
PMID: 26877611
Journal: Int J Oncol. 2016 May;48(5):2025-34.
Title: Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines.
Author: Muller, Alena|Barat, Samarpita|Chen, Xi|Bui, Khac Cuong|Bozko, Przemyslaw|Malek, Nisar P|Plentz, Ruben R
PMID: 26935541
Journal: Oncotarget. 2016 Apr 19;7(16):22339-54.
Title: miR-101 targeting ZFX suppresses tumor proliferation and metastasis by regulating the MAPK/Erk and Smad pathways in gallbladder carcinoma.
Author: Bao, Run-Fa|Shu, Yi-Jun|Hu, Yun-Ping|Wang, Xu-An|Zhang, Fei|Liang, Hai-Bin|Ye, Yuan-Yuan|Li, Huai-Feng|Xiang, Shan-Shan|Weng, Hao|Cao, Yang|Wu, Xiang-Song|Li, Mao-Lan|Wu, Wen-Guang|Zhang, Yi-Jian|Jiang, Lin|Dong, Qian|Liu, Ying-Bin
PMID: 26968949
Journal: J Exp Clin Cancer Res. 2016 Apr 16;35:68.
Title: Prohibitin overexpression predicts poor prognosis and promotes cell proliferation and invasion through ERK pathway activation in gallbladder cancer.
Author: Cao, Yang|Liang, Haibin|Zhang, Fei|Luan, Zhou|Zhao, Shuai|Wang, Xu-An|Liu, Shibo|Bao, Runfa|Shu, Yijun|Ma, Qiang|Zhu, Jian|Liu, Yingbin
PMID: 27084680
Journal: PLoS One. 2016 Sep 14;11(9):e0162594.
Title: Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation.
Author: Hall, Terence G|Yu, Yi|Eathiraj, Sudharshan|Wang, Yunxia|Savage, Ronald E|Lapierre, Jean-Marc|Schwartz, Brian|Abbadessa, Giovanni
PMID: 27627808
Journal: Oncotarget. 2016 Nov 8;7(45):72833-72844.
Title: Long non-coding RNA CRNDE promotes gallbladder carcinoma carcinogenesis and as a scaffold of DMBT1 and C-IAP1 complexes to activating PI3K-AKT pathway.
Author: Shen, Sheng|Liu, Han|Wang, Yueqi|Wang, Jiwen|Ni, Xiaolin|Ai, Zhilong|Pan, Hongtao|Liu, Houbao|Shao, Yebo
PMID: 27637083
Journal: Biol Pharm Bull. 2017 Apr 1;40(4):495-503.
Title: Growth Inhibition of Refractory Human Gallbladder Cancer Cells by Retinol, and Its Mechanism of Action.
Author: Li, Chuan|Imai, Masahiko|Hasegawa, Shinya|Yamasaki, Masahiro|Takahashi, Noriko
PMID: 28100868
Journal: Apoptosis. 2017 Nov;22(11):1473-1484.
Title: Piperlongumine induces G2/M phase arrest and apoptosis in cholangiocarcinoma cells through the ROS-JNK-ERK signaling pathway.
Author: Thongsom, Sunisa|Suginta, Wipa|Lee, Kyung Jin|Choe, Han|Talabnin, Chutima
PMID: 28913568
Journal: Oncotarget. 2017 Apr 18;8(16):26169-26184.
Title: Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer.
Author: Weber, Helga|Valbuena, Jose R|Barbhuiya, Mustafa A|Stein, Stefan|Kunkel, Hana|Garcia, Patricia|Bizama, Carolina|Riquelme, Ismael|Espinoza, Jaime A|Kurtz, Stephen E|Tyner, Jeffrey W|Calderon, Juan Francisco|Corvalan, Alejandro H|Grez, Manuel|Pandey, Akhile
PMID: 28412732
Journal: Pathol Res Pract. 2017 May;213(5):476-482.
Title: The ERK/MAPK pathway is overexpressed and activated in gallbladder cancer.
Author: Buchegger, Kurt|Silva, Ramon|Lopez, Jaime|Ili, Carmen|Araya, Juan Carlos|Leal, Pamela|Brebi, Priscilla|Riquelme, Ismael|Roa, Juan Carlos
PMID: 28285962
Journal: Mol Cancer Ther. 2017 Jun;16(6):1145-1154.
Title: Resistance Mechanism against Trastuzumab in HER2-Positive Cancer Cells and Its Negation by Src Inhibition.
Author: Jin, Mei Hua|Nam, Ah-Rong|Park, Ji Eun|Bang, Ju-Hee|Bang, Yung-Jue|Oh, Do-Youn
PMID: 28223426
Journal: Biochimie. 2017 Jan;132:152-160.
Title: The emerging role of long non-coding RNA in gallbladder cancer pathogenesis.
Author: Khandelwal, Akanksha|Malhotra, Akshay|Jain, Manju|Vasquez, Karen M|Jain, Aklank
PMID: 27894946
Journal: Cytotechnology. 2018 Feb;70(1):439-448.
Title: Metformin synergistically enhances antitumor activity of cisplatin in gallbladder cancer via the PI3K/AKT/ERK pathway.
Author: Bi, Tingting|Zhu, Ao|Yang, Xufeng|Qiao, Huiying|Tang, Jinmei|Liu, Yan|Lv, Rong
PMID: 29110119
Journal: Cell Death Dis. 2018 Jan 18;9(2):31.
Title: Efficacy of MEK inhibition in a K-Ras-driven cholangiocarcinoma preclinical model.
Author: Dong, Mingjie|Liu, Xianqiong|Evert, Katja|Utpatel, Kirsten|Peters, Michele|Zhang, Shanshan|Xu, Zhong|Che, Li|Cigliano, Antonio|Ribback, Silvia|Dombrowski, Frank|Cossu, Antonio|Gordan, John|Calvisi, Diego F|Evert, Matthias|Liu, Yan|Chen, Xin
PMID: 29348467
Journal: Biochem Biophys Res Commun. 2018 May 15;499(3):433-440.
Title: Inhibition of KLHL21 prevents cholangiocarcinoma progression through regulating cell proliferation and motility, arresting cell cycle and reducing Erk activation.
Author: Chen, Jian|Song, Wenfeng|Du, Yehui|Li, Zequn|Xuan, Zefeng|Zhao, Long|Chen, Jun|Zhao, Yongchao|Tuo, Biguang|Zheng, Shusen|Song, Penghong
PMID: 29574153
Journal: Cancer Lett. 2018 Aug 28;430:97-108.
Title: EMP3, which is regulated by miR-663a, suppresses gallbladder cancer progression via interference with the MAPK/ERK pathway.
Author: Ma, Qiang|Zhang, Yijian|Liang, Haibin|Zhang, Fei|Liu, Fatao|Chen, Shili|Hu, Yunping|Jiang, Lin|Hao, Yajuan|Li, Maolan|Liu, Yingbin
PMID: 29778567
Journal: J Cell Mol Med. 2018 Aug 30.
Title: Sprouty2 suppresses progression and correlates to favourable prognosis of intrahepatic cholangiocarcinoma via antagonizing FGFR2 signalling.
Author: Xu, Yun-Fei|Liu, Hong-Da|Liu, Zeng-Li|Pan, Chang|Yang, Xiao-Qing|Ning, Shang-Lei|Zhang, Zong-Li|Guo, Sen|Yu, Jin-Ming
PMID: 30160357
Journal: J Surg Res. 2018 Nov;231:116-125.
Title: IDH1 mutation correlates with a beneficial prognosis and suppresses tumor growth in IHCC.
Author: Wang, Jian|Zhang, Zhan-Guo|Ding, Ze-Yang|Dong, Wei|Liang, Hui-Fang|Chu, Liang|Zhang, Bi-Xiang|Chen, Xiao-Ping
PMID: 30278918
Journal: Int J Cancer. 2018 Oct 10.
Title: ERBB2 and KRAS Alterations Mediate Response to EGFR Inhibitors in Early Stage Gallbladder Cancer.
Author: Iyer, Prajish|Shrikhande, Shailesh V|Ranjan, Malika|Joshi, Asim|Gardi, Nilesh|Prasad, Ratnam|Dharavath, Bhasker|Thorat, Rahul|Salunkhe, Sameer|Sahoo, Bikram|Chandrani, Pratik|Kore, Hitesh|Mohanty, Bhabani|Chaudhari, Vikram|Choughule, Anuradha|Kawle, Dhana
PMID: 30304546
Journal: Int J Mol Sci. 2018 Oct 12;19(10). pii: ijms19103141.
Title: MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner.
Author: Miao, Wenyu|Sakai, Katsuya|Imamura, Ryu|Ito, Kenichiro|Suga, Hiroaki|Sakuma, Tetsushi|Yamamoto, Takashi|Matsumoto, Kunio
PMID: 30322054