Primary Site >> Pancreatic Cancer
Gene >> DPYD
| 1. | |||||||||||
| Journal: | Int J Oncol. 1997 Nov;11(5):1041-4. | ||||||||||
| Title: | Enhancing 5-fluorouracil cytotoxicity by inhibiting dihydropyrimidine dehydrogenase activity with uracil in human tumor cells. | ||||||||||
| Author: | Takechi, T|Uchida, J|Fujioka, A|Fukushima, M | ||||||||||
| PMID: | 21528302 | ||||||||||
| 2. | |||||||||||
| Journal: | Oncology (Williston Park). 1998 Oct;12(10 Suppl 7):52-6. | ||||||||||
| Title: | Clinical development of eniluracil: current status. | ||||||||||
| Author: | Hohneker, J A | ||||||||||
| PMID: | 9830627 | ||||||||||
| 3. | |||||||||||
| Journal: | Jpn J Cancer Res. 1998 Nov;89(11):1144-53. | ||||||||||
| Title: | Relationship between protein levels and gene expression of dihydropyrimidine dehydrogenase in human tumor cells during growth in culture and in nude mice. | ||||||||||
| Author: | Takechi, T|Okabe, H|Fujioka, A|Murakami, Y|Fukushima, M | ||||||||||
| PMID: | 9914783 | ||||||||||
| 4. | |||||||||||
| Journal: | Clin Cancer Res. 1999 Apr;5(4):883-9. | ||||||||||
| Title: | Dihydropyrimidine dehydrogenase activity and messenger RNA level may be related to the antitumor effect of 5-fluorouracil on human tumor xenografts in nude mice. | ||||||||||
| Author: | Ishikawa, Y|Kubota, T|Otani, Y|Watanabe, M|Teramoto, T|Kumai, K|Kitajima, M|Takechi, T|Okabe, H|Fukushima, M | ||||||||||
| PMID: | 10213225 | ||||||||||
| 5. | |||||||||||
| Journal: | Int J Oncol. 2000 Jul;17(1):33-8. | ||||||||||
| Title: | Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues. | ||||||||||
| Author: | Mori, K|Hasegawa, M|Nishida, M|Toma, H|Fukuda, M|Kubota, T|Nagasue, N|Yamana, H|Hirakawa-YS Chung, K|Ikeda, T|Takasaki, K|Oka, M|Kameyama, M|Toi, M|Fujii, H|Kitamura, M|Murai, M|Sasaki, H|Ozono, S|Makuuchi, H|Shimada, Y|Onishi, Y|Aoyagi, S|Mizutani, K|Oga | ||||||||||
| PMID: | 10853015 | ||||||||||
| 6. | |||||||||||
| Journal: | Cancer Invest. 2000;18(6):516-20. | ||||||||||
| Title: | Dihydropyrimidine dehydrogenase activity in human pancreatic tumor tissues. | ||||||||||
| Author: | Nagakawa, T|Kayahara, M|Ohta, T|Kitagawa, H|Mikami, K|Kurata, T|Otsuji, S | ||||||||||
| PMID: | 10923099 | ||||||||||
| 7. | |||||||||||
| Journal: | Expert Opin Investig Drugs. 2000 Jul;9(7):1635-49. | ||||||||||
| Title: | Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase. | ||||||||||
| Author: | Schilsky, R L|Kindler, H L | ||||||||||
| PMID: | 11060767 | ||||||||||
| 8. | |||||||||||
| Journal: | Invest New Drugs. 2000 Nov;18(4):383-90. | ||||||||||
| Title: | Clinical development of eniluracil/fluorouracil: an oral treatment for patients with solid tumors. | ||||||||||
| Author: | Levin, J|Hohneker, J | ||||||||||
| PMID: | 11081574 | ||||||||||
| 9. | |||||||||||
| Journal: | Anticancer Res. 2003 Nov-Dec;23(6C):4663-9. | ||||||||||
| Title: | Up-regulation in dihydropyrimidine dehydrogenase activity by raltitrexed causes antagonism in combination with 5-fluorouracil. | ||||||||||
| Author: | Nozoe, Yasuhiro|Ogata, Yutaka|Araki, Yasumi|Sasatomi, Teruo|Fukumori, Hiroyuki|Shirouzu, Kazuo | ||||||||||
| PMID: | 14981911 | ||||||||||
| 10. | |||||||||||
| Journal: | Zhonghua Zhong Liu Za Zhi. 2004 Oct;26(10):618-20. | ||||||||||
| Title: | [The thymidine phosphorylase to dihydropyrimidine dehydrogenase ratio in pancreatic cancer]. | ||||||||||
| Author: | Yu, Xian-jun|Jiang, Yong-jian|Fu, De-liang|Ni, Quan-xing | ||||||||||
| PMID: | 15634525 | ||||||||||
| 11. | |||||||||||
| Journal: | Ann Surg. 2004 Nov;240(5):840-4. | ||||||||||
| Title: | Clinical significance of dihydropyrimidine dehydrogenase in adjuvant 5-fluorouracil liver perfusion chemotherapy for pancreatic cancer. | ||||||||||
| Author: | Nakayama, Shigeki|Takeda, Shin|Kawase, Yoshihisa|Inoue, Soichiro|Kaneko, Tetsuya|Nakao, Akimasa | ||||||||||
| PMID: | 15492566 | ||||||||||
| 12. | |||||||||||
| Journal: | Pharmacogenomics J. 2005;5(4):226-43. | ||||||||||
| Title: | Genetic factors influencing pyrimidine-antagonist chemotherapy. | ||||||||||
| Author: | Maring, J G|Groen, H J M|Wachters, F M|Uges, D R A|de Vries, E G E | ||||||||||
| PMID: | 16041392 | ||||||||||
| 13. | |||||||||||
| Journal: | J Clin Oncol. 2005 Dec 1;23(34):8679-87. | ||||||||||
| Title: | Phase I study of capecitabine with concomitant radiotherapy for patients with locally advanced pancreatic cancer: expression analysis of genes related to outcome. | ||||||||||
| Author: | Saif, M Wasif|Eloubeidi, Mohammaed A|Russo, Suzanne|Steg, Adam|Thornton, Jennifer|Fiveash, John|Carpenter, Mark|Blanquicett, Carmello|Diasio, Robert B|Johnson, Martin R | ||||||||||
| PMID: | 16314628 | ||||||||||
| 14. | |||||||||||
| Journal: | Cancer Invest. 2006 Feb;24(1):9-17. | ||||||||||
| Title: | A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract. | ||||||||||
| Author: | Czito, Brian G|Hong, Timothy J|Cohen, Darrel P|Petros, William P|Tyler, Douglas S|Pappas, Theodore N|Yu, Daohai|Lee, Catherine G|Lockhart, Albert C|Morse, Michael A|Fernando, Nishan|Hurwitz, Herbert I | ||||||||||
| PMID: | 16466986 | ||||||||||
| 15. | |||||||||||
| Journal: | Int J Clin Oncol. 2007 Apr;12(2):111-9. | ||||||||||
| Title: | Role of thymidine phosphorylase and orotate phosphoribosyltransferase mRNA expression and its ratio to dihydropyrimidine dehydrogenase in the prognosis and clinicopathological features of patients with pancreatic cancer. | ||||||||||
| Author: | Miyake, Kotaro|Imura, Satoru|Yoshizumi, Tomoharu|Ikemoto, Tetsuya|Morine, Yuji|Shimada, Mitsuo | ||||||||||
| PMID: | 17443278 | ||||||||||
| 16. | |||||||||||
| Journal: | Anticancer Res. 2007 Jul-Aug;27(4B):2241-9. | ||||||||||
| Title: | Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer. | ||||||||||
| Author: | Tsujie, Masanori|Nakamori, Shoji|Nakahira, Shin|Takahashi, Yuji|Hayashi, Nobuyasu|Okami, Jiro|Nagano, Hiroaki|Dono, Keizo|Umeshita, Koji|Sakon, Masato|Monden, Morito | ||||||||||
| PMID: | 17695509 | ||||||||||
| 17. | |||||||||||
| Journal: | Cancer J. 2007 Jul-Aug;13(4):247-56. | ||||||||||
| Title: | Phase II study of capecitabine with concomitant radiotherapy for patients with locally advanced pancreatic cancer: up-regulation of thymidine phosphorylase. | ||||||||||
| Author: | Saif, Muhammad Wasif|Black, Glenda|Roy, Shalija|Bell, Diana|Russo, Suzanne|Eloubeidi, Mohamed A|Steg, Adam|Johnson, Martin R|Zelterman, Daniel|Diasio, Robert B | ||||||||||
| PMID: | 17762760 | ||||||||||
| 18. | |||||||||||
| Journal: | Support Cancer Ther. 2007 Sep 1;4(4):211-8. | ||||||||||
| Title: | Palmar-plantar erythrodysesthesia in patients receiving capecitabine and intratumor thymidine phosphorylase and dihydropyrimidine dehydrogenase: is there a pharmacologic explanation? | ||||||||||
| Author: | Saif, Muhammad Wasif|Juneja, Vinni|Black, Glenda|Thronton, Jennifer|Johnson, Martin R|Diasio, Robert B | ||||||||||
| PMID: | 18632519 | ||||||||||
| 19. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2008 Dec;63(1):85-9. | ||||||||||
| Title: | High intratumoral dihydropyrimidine dehydrogenase mRNA levels in pancreatic cancer associated with a high rate of response to S-1. | ||||||||||
| Author: | Kuramochi, Hidekazu|Hayashi, Kazuhiko|Uchida, Kazumi|Nakajima, Go|Hatori, Takashi|Danenberg, Kathleen D|Danenberg, Peter V|Yamamoto, Masakazu | ||||||||||
| PMID: | 18309485 | ||||||||||
| 20. | |||||||||||
| Journal: | Int J Mol Med. 2008 Dec;22(6):709-16. | ||||||||||
| Title: | Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis. | ||||||||||
| Author: | Fukui, Yousuke|Oka, Toshinori|Nagayama, Sekio|Danenberg, Peter V|Danenberg, Kathleen D|Fukushima, Masakazu | ||||||||||
| PMID: | 19020767 | ||||||||||
| 21. | |||||||||||
| Journal: | JOP. 2008 Mar 8;9(2):226-9. | ||||||||||
| Title: | Atypical toxicity associated with 5-Fluororacil in a DPD-deficient patient with pancreatic cancer. Is ethnicity a risk factor? | ||||||||||
| Author: | Saif, Muhammad Wasif|Seller, Sandra|Diasio, Robert B | ||||||||||
| PMID: | 18326935 | ||||||||||
| 22. | |||||||||||
| Journal: | Cancer Sci. 2008 Sep;99(9):1859-64. | ||||||||||
| Title: | Establishment and molecular profiling of a novel human pancreatic cancer panel for 5-FU. | ||||||||||
| Author: | Yanagihara, Kazuyoshi|Takigahira, Misato|Tanaka, Hiromi|Arao, Tokuzo|Aoyagi, Yasuyuki|Oda, Tatsuya|Ochiai, Atsushi|Nishio, Kazuto | ||||||||||
| PMID: | 18691340 | ||||||||||
| 23. | |||||||||||
| Journal: | JOP. 2009 Mar 9;10(2):215-20. | ||||||||||
| Title: | Cardiotoxicity of 5-fluorouracil and capecitabine in a pancreatic cancer patient with a novel mutation in the dihydropyrimidine dehydrogenase gene. | ||||||||||
| Author: | Shahrokni, Armin|Rajebi, Mohammad Reza|Harold, Laurie|Saif, Muhammad Wasif | ||||||||||
| PMID: | 19287123 | ||||||||||
| 24. | |||||||||||
| Journal: | Pathobiology. 2009;76(4):193-8. | ||||||||||
| Title: | Thymidylate synthase and dihydropyrimidine dehydrogenase are upregulated in pancreatic and biliary tract cancers. | ||||||||||
| Author: | Shimoda, Mitsugi|Sawada, Tokihiko|Kubota, Keiichi | ||||||||||
| PMID: | 19571608 | ||||||||||
| 25. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2010 Jul;66(2):333-43. | ||||||||||
| Title: | Can the 2-(13)C-uracil breath test be used to predict the effect of the antitumor drug S-1? | ||||||||||
| Author: | Ishii, Yukimoto|Suzuki, Shigeru|Takahashi, Yasuo|Takayama, Tadatoshi|Asai, Satoshi | ||||||||||
| PMID: | 19921195 | ||||||||||
| 26. | |||||||||||
| Journal: | Int J Clin Oncol. 2010 Feb;15(1):39-45. | ||||||||||
| Title: | Clinical significance of dihydropyrimidine dehydrogenase and thymidylate synthase expression in patients with pancreatic cancer. | ||||||||||
| Author: | Nakahara, Osamu|Takamori, Hiroshi|Tanaka, Hiroshi|Sakamoto, Yasuo|Ikuta, Yoshiaki|Furuhashi, Satoshi|Watanabe, Masayuki|Beppu, Toru|Hirota, Masahiko|Kanemitsu, Keiichiro|Baba, Hideo | ||||||||||
| PMID: | 20072795 | ||||||||||
| 27. | |||||||||||
| Journal: | Exp Ther Med. 2011 Nov;2(6):1097-1103. | ||||||||||
| Title: | Impact of dihydropyrimidine dehydrogenase and gamma-glutamyl hydrolase on the outcomes of patients treated with gemcitabine or S-1 as adjuvant chemotherapy for advanced pancreatic cancer. | ||||||||||
| Author: | Nakamura, Ayako|Hayashi, Kazuhiko|Nakajima, Go|Kamikozuru, Hirotaka|Okuyama, Ryuji|Kuramochi, Hidekazu|Hatori, Takashi|Yamamoto, Masakazu | ||||||||||
| PMID: | 22977627 | ||||||||||
| 28. | |||||||||||
| Journal: | Zhonghua Wai Ke Za Zhi. 2011 Apr 1;49(4):330-4. | ||||||||||
| Title: | [Expression of dihydropyrimidine dehydrogenase negatively correlated with the prognosis of pancreatic ductal adenocarcinoma]. | ||||||||||
| Author: | Fang, Yuan|Ji, Yuan|Lou, Wen-hui | ||||||||||
| PMID: | 21612699 | ||||||||||
| 29. | |||||||||||
| Journal: | Pancreas. 2011 Jul;40(5):657-63. | ||||||||||
| Title: | Genetic effects and modifiers of radiotherapy and chemotherapy on survival in pancreatic cancer. | ||||||||||
| Author: | Zeng, Hongmei|Yu, Herbert|Lu, Lingeng|Jain, Dhanpat|Kidd, Mark S|Saif, M Wasif|Chanock, Stephen J|Hartge, Patricia|Risch, Harvey A | ||||||||||
| PMID: | 21487324 | ||||||||||
| 30. | |||||||||||
| Journal: | Ann Surg Oncol. 2012 Jul;19 Suppl 3:S646-55. | ||||||||||
| Title: | Combined analysis of dihydropyrimidine dehydrogenase and human equilibrative nucleoside transporter 1 expression predicts survival of pancreatic carcinoma patients treated with adjuvant gemcitabine plus S-1 chemotherapy after surgical resection. | ||||||||||
| Author: | Kondo, Naru|Murakami, Yoshiaki|Uemura, Kenichiro|Sudo, Takeshi|Hashimoto, Yasushi|Nakashima, Akira|Sueda, Taijiro | ||||||||||
| PMID: | 22086444 | ||||||||||
| 31. | |||||||||||
| Journal: | Br J Surg. 2015 Jun;102(7):746-54. | ||||||||||
| Title: | Randomized clinical trial of adjuvant chemotherapy with S-1 versus gemcitabine after pancreatic cancer resection. | ||||||||||
| Author: | Shimoda, M|Kubota, K|Shimizu, T|Katoh, M | ||||||||||
| PMID: | 25833230 | ||||||||||
| 32. | |||||||||||
| Journal: | Pancreas. 2016 Mar;45(3):425-33. | ||||||||||
| Title: | Nab-Paclitaxel Plus S-1 Shows Increased Antitumor Activity in Patient-Derived Pancreatic Cancer Xenograft Mouse Models. | ||||||||||
| Author: | Li, Jian-Ang|Xu, Xue-Feng|Han, Xu|Fang, Yuan|Shi, Chen-Ye|Jin, Da-Yong|Lou, Wen-Hui | ||||||||||
| PMID: | 26495780 | ||||||||||
| 33. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2016 Jul;78(1):151-6. | ||||||||||
| Title: | Benefit of uridine triacetate (Vistogard) in rescuing severe 5-fluorouracil toxicity in patients with dihydropyrimidine dehydrogenase (DPYD) deficiency. | ||||||||||
| Author: | Saif, Muhammad Wasif|Diasio, Robert B | ||||||||||
| PMID: | 27278667 | ||||||||||
| 34. | |||||||||||
| Journal: | Anticancer Drugs. 2017 Jun;28(5):551-556. | ||||||||||
| Title: | A nomogram to predict 5-fluorouracil toxicity: when pharmacogenomics meets the patient. | ||||||||||
| Author: | Botticelli, Andrea|Onesti, Concetta E|Strigari, Lidia|Occhipinti, Mario|Di Pietro, Francesca R|Cerbelli, Bruna|Petremolo, Antonella|Anselmi, Elisabetta|Macrini, Serena|Roberto, Michela|Falcone, Rosa|Lionetto, Luana|Borro, Marina|Milano, Annalisa|Gentile, | ||||||||||
| PMID: | 28296649 | ||||||||||
| 35. | |||||||||||
| Journal: | Anticancer Res. 2017 May;37(5):2465-2476. | ||||||||||
| Title: | Combined Analyses of hENT1, TS, and DPD Predict Outcomes of Borderline-resectable Pancreatic Cancer. | ||||||||||
| Author: | Yabushita, Yasuhiro|Mori, Ryutaro|Taniguchi, Koichi|Matsuyama, Ryusei|Kumamoto, Takafumi|Sakamaki, Kentaro|Kubota, Kensuke|Endo, Itaru | ||||||||||
| PMID: | 28476815 | ||||||||||
| 36. | |||||||||||
| Journal: | Oncol Lett. 2017 Aug;14(2):1505-1511. | ||||||||||
| Title: | Clinical implications of dihydropyrimidine dehydrogenase expression in patients with pancreatic cancer who undergo curative resection with S-1 adjuvant chemotherapy. | ||||||||||
| Author: | Murakawa, Masaaki|Aoyama, Toru|Miyagi, Yohei|Atsumi, Yosuke|Kazama, Keisuke|Yamaoku, Koichiro|Kanazawa, Amane|Shiozawa, Manabu|Kobayashi, Satoshi|Ueno, Makoto|Morimoto, Manabu|Yamamoto, Naoto|Oshima, Takashi|Yoshikawa, Takaki|Rino, Yasushi|Masuda, Munetak | ||||||||||
| PMID: | 28789372 | ||||||||||
| 37. | |||||||||||
| Journal: | Br J Cancer. 2018 Apr;118(7):947-954. | ||||||||||
| Title: | Expression of dihydropyrimidine dehydrogenase (DPD) and hENT1 predicts survival in pancreatic cancer. | ||||||||||
| Author: | Elander, N O|Aughton, K|Ghaneh, P|Neoptolemos, J P|Palmer, D H|Cox, T F|Campbell, F|Costello, E|Halloran, C M|Mackey, J R|Scarfe, A G|Valle, J W|McDonald, A C|Carter, R|Tebbutt, N C|Goldstein, D|Shannon, J|Dervenis, C|Glimelius, B|Deakin, M|Charnley, R M| | ||||||||||
| PMID: | 29515256 | ||||||||||