Primary Site >> Stomach Cancer
Gene >> DPYD
| 1. | |||||||||||
| Journal: | J Clin Oncol. 1998 Aug;16(8):2877-85. | ||||||||||
| Title: | Uracil-tegafur in gastric carcinoma: a comprehensive review. | ||||||||||
| Author: | Takiuchi, H|Ajani, J A | ||||||||||
| PMID: | 9704742 | ||||||||||
| 2. | |||||||||||
| Journal: | Eur J Cancer. 1998 Oct;34(11):1715-20. | ||||||||||
| Title: | Late phase II study of novel oral fluoropyrimidine anticancer drug S-1 (1 M tegafur-0.4 M gimestat-1 M otastat potassium) in advanced gastric cancer patients. | ||||||||||
| Author: | Sakata, Y|Ohtsu, A|Horikoshi, N|Sugimachi, K|Mitachi, Y|Taguchi, T | ||||||||||
| PMID: | 9893658 | ||||||||||
| 3. | |||||||||||
| Journal: | Clin Cancer Res. 1999 Apr;5(4):883-9. | ||||||||||
| Title: | Dihydropyrimidine dehydrogenase activity and messenger RNA level may be related to the antitumor effect of 5-fluorouracil on human tumor xenografts in nude mice. | ||||||||||
| Author: | Ishikawa, Y|Kubota, T|Otani, Y|Watanabe, M|Teramoto, T|Kumai, K|Kitajima, M|Takechi, T|Okabe, H|Fukushima, M | ||||||||||
| PMID: | 10213225 | ||||||||||
| 4. | |||||||||||
| Journal: | Clin Cancer Res. 1999 Aug;5(8):2000-5. | ||||||||||
| Title: | Pharmacokinetic study of S-1, a novel oral fluorouracil antitumor drug. | ||||||||||
| Author: | Hirata, K|Horikoshi, N|Aiba, K|Okazaki, M|Denno, R|Sasaki, K|Nakano, Y|Ishizuka, H|Yamada, Y|Uno, S|Taguchi, T|Shirasaka, T | ||||||||||
| PMID: | 10473078 | ||||||||||
| 5. | |||||||||||
| Journal: | Anticancer Res. 1999 Nov-Dec;19(6C):5635-40. | ||||||||||
| Title: | Thymidylate synthetase and dihydropyrimidine dehydrogenase levels in gastric cancer. | ||||||||||
| Author: | Ishikawa, Y|Kubota, T|Otani, Y|Watanabe, M|Teramoto, T|Kumai, K|Takechi, T|Okabe, H|Fukushima, M|Kitajima, M | ||||||||||
| PMID: | 10697632 | ||||||||||
| 6. | |||||||||||
| Journal: | Jpn J Cancer Res. 2000 Jan;91(1):105-12. | ||||||||||
| Title: | Dihydropyrimidine dehydrogenase and messenger RNA levels in gastric cancer: possible predictor for sensitivity to 5-fluorouracil. | ||||||||||
| Author: | Ishikawa, Y|Kubota, T|Otani, Y|Watanabe, M|Teramoto, T|Kumai, K|Takechi, T|Okabe, H|Fukushima, M|Kitajima, M | ||||||||||
| PMID: | 10744051 | ||||||||||
| 7. | |||||||||||
| Journal: | Int J Oncol. 2000 Jul;17(1):33-8. | ||||||||||
| Title: | Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues. | ||||||||||
| Author: | Mori, K|Hasegawa, M|Nishida, M|Toma, H|Fukuda, M|Kubota, T|Nagasue, N|Yamana, H|Hirakawa-YS Chung, K|Ikeda, T|Takasaki, K|Oka, M|Kameyama, M|Toi, M|Fujii, H|Kitamura, M|Murai, M|Sasaki, H|Ozono, S|Makuuchi, H|Shimada, Y|Onishi, Y|Aoyagi, S|Mizutani, K|Oga | ||||||||||
| PMID: | 10853015 | ||||||||||
| 8. | |||||||||||
| Journal: | Anticancer Res. 2000 Jul-Aug;20(4):2457-62. | ||||||||||
| Title: | 5-fluorouracil sensitivity and dihydropyrimidine dehydrogenase activity in advanced gastric cancer. | ||||||||||
| Author: | Inada, T|Ogata, Y|Kubota, T|Tomikawa, M|Yamamoto, S|Andoh, J|Ozawa, I|Hishinuma, S|Shimizu, H|Kotake, K | ||||||||||
| PMID: | 10953310 | ||||||||||
| 9. | |||||||||||
| Journal: | Int J Oncol. 2000 Oct;17(4):653-8. | ||||||||||
| Title: | Clinical implications of immunoreactivity of thymidylate synthase and dihydropyrimidine dehydrogenase in gastric cancer treated with oral fluoropyrimidine (S-1). Study Group of S-1 for Gastric Cancer. | ||||||||||
| Author: | Miyamoto, S|Boku, N|Ohtsu, A|Yoshida, S|Ochiai, A|Okabe, H|Fukushima, M | ||||||||||
| PMID: | 10995874 | ||||||||||
| 10. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2000 Nov;27(13):2043-7. | ||||||||||
| Title: | [Recent advance in gastric cancer chemotherapy]. | ||||||||||
| Author: | Kubota, T | ||||||||||
| PMID: | 11103235 | ||||||||||
| 11. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2001 May;28(5):649-54. | ||||||||||
| Title: | [Significance of pyrimidine nucleoside phosphorylase (PyNPase) and dihydropyrimidine dehydrogenase (DPD) in advanced gastric cancers]. | ||||||||||
| Author: | Tsukayama, S|Hirano, M|Murakami, N|Uno, Y|Nozawa, H|Yoshino, H|Orta, N|Kikkawa, H|Masuda, S | ||||||||||
| PMID: | 11383213 | ||||||||||
| 12. | |||||||||||
| Journal: | Int J Oncol. 2001 Aug;19(2):341-6. | ||||||||||
| Title: | Changes in intratumoral thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) mRNA expression in colorectal and gastric cancer during continuous tegafur infusion. | ||||||||||
| Author: | Uchida, K|Hayashi, K|Kuramochi, H|Takasaki, K | ||||||||||
| PMID: | 11445849 | ||||||||||
| 13. | |||||||||||
| Journal: | Jpn J Cancer Res. 2001 Oct;92(10):1127-32. | ||||||||||
| Title: | High expression of thymidylate synthase leads to resistance to 5-fluorouracil in biliary tract carcinoma in vitro. | ||||||||||
| Author: | Habara, K|Ajiki, T|Kamigaki, T|Nakamura, T|Kuroda, Y | ||||||||||
| PMID: | 11676864 | ||||||||||
| 14. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2002 Jan;29(1):119-23. | ||||||||||
| Title: | [A complete response after neoadjuvant chemotherapy for advanced gastric cancer with esophageal invasion]. | ||||||||||
| Author: | Yabusaki, Hiroshi|Nashimoto, Atsushi|Tanaka, Otsuo | ||||||||||
| PMID: | 11816467 | ||||||||||
| 15. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2002 Feb;29(2):245-52. | ||||||||||
| Title: | [Dihydropyrimidine dehydrogenase expression in gastric cancer using anti-human dihydropyrimidine dehydrogenase monoclonal antibody]. | ||||||||||
| Author: | Kitago, Kuniaki|Ichikawa, Wataru|Uetake, Hiroyuki|Nihei, Zenro | ||||||||||
| PMID: | 11865631 | ||||||||||
| 16. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2002 Apr;49(4):267-73. | ||||||||||
| Title: | Dihydropyrimidine dehydrogenase expression in preoperative biopsy and surgically resected specimens of gastric carcinoma. | ||||||||||
| Author: | Nozawa, Hiroaki|Tsukui, Hajime|Nishida, Koichiro|Yakumaru, Kazuhiro|Nagawa, Hirokazu|Sekikawa, Takayoshi | ||||||||||
| PMID: | 11914904 | ||||||||||
| 17. | |||||||||||
| Journal: | Anticancer Drugs. 2002 Apr;13(4):411-6. | ||||||||||
| Title: | Dihydropyrimidine dehydrogenase-related enzymes predict efficacy and adverse reactions of UFT1+cisplatin neoadjuvant chemotherapy for gastric cancer. | ||||||||||
| Author: | Takiguchi, Nobuhiro|Koda, Keiji|Ooshima, Hirokazu|Oda, Kenji|Suzuki, Hirofumi|Ishii, Rumiko|Miyazaki, Masaru | ||||||||||
| PMID: | 11984087 | ||||||||||
| 18. | |||||||||||
| Journal: | Anticancer Res. 2002 Mar-Apr;22(2A):761-8. | ||||||||||
| Title: | Roles of thymidylate synthase and dihydropyrimidine dehydrogenase in tumor progression and sensitivity to 5-fluorouracil in human gastric cancer. | ||||||||||
| Author: | Terashima, M|Irinoda, T|Fujiwara, H|Nakaya, T|Takagane, A|Abe, K|Yonezawa, H|Oyama, K|Inaba, T|Saito, K|Takechi, T|Fukushima, M | ||||||||||
| PMID: | 12014648 | ||||||||||
| 19. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2002 Jul;50(1):25-32. | ||||||||||
| Title: | Pharmacokinetic study of S-1, a novel oral fluorouracil antitumor agent in animal model and in patients with impaired renal function. | ||||||||||
| Author: | Ikeda, Masataka|Furukawa, Hiroshi|Imamura, Hiroshi|Shimizu, Jyunzo|Ishida, Hideyuki|Masutani, Seizo|Tatsuta, Masayuki|Kawasaki, Takatoshi|Satomi, Takashi | ||||||||||
| PMID: | 12111108 | ||||||||||
| 20. | |||||||||||
| Journal: | Eur J Cancer. 2002 Dec;38(18):2375-81. | ||||||||||
| Title: | Role of thymidine phosphorylase and dihydropyrimidine dehydrogenase in tumour progression and sensitivity to doxifluridine in gastric cancer patients. | ||||||||||
| Author: | Terashima, M|Fujiwara, H|Takagane, A|Abe, K|Araya, M|Irinoda, T|Yonezawa, H|Nakaya, T|Oyama, K|Takahashi, M|Saito, K | ||||||||||
| PMID: | 12460781 | ||||||||||
| 21. | |||||||||||
| Journal: | Jpn J Cancer Res. 2002 Dec;93(12):1342-50. | ||||||||||
| Title: | Quantitative measurement of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA level in gastric cancer by real-time RT-PCR. | ||||||||||
| Author: | Fujiwara, Hisataka|Terashima, Masanori|Irinoda, Takashi|Takagane, Akinori|Abe, Kaoru|Kashiwaba, Masahiro|Oyama, Kennichi|Takahashi, Masanori|Maesawa, Chihaya|Saito, Kazuyoshi|Takechi, Teiji|Fukushima, Masakazu | ||||||||||
| PMID: | 12495474 | ||||||||||
| 22. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2003 Mar;51(3):240-6. | ||||||||||
| Title: | Intermittent FLDP: 24-h infusion of 5-FU on days 1, 3 and 5 combined with low-dose cisplatin on days 1-5 for gastric cancer, and its pharmacologic and kinetic rationale. | ||||||||||
| Author: | Terashima, Masanori|Irinoda, Takashi|Kawamura, Hidenobu|Takagane, Akinori|Abe, Kaoru|Oyama, Kenichi|Fujiwara, Hisataka|Saito, Kazuyoshi|Gotoh, Mitsukazu|Shirasaka, Tetsuhiko | ||||||||||
| PMID: | 12655443 | ||||||||||
| 23. | |||||||||||
| Journal: | Gastric Cancer. 2003;6 Suppl 1:2-8. | ||||||||||
| Title: | S-1 in gastric cancer: a comprehensive review. | ||||||||||
| Author: | Maehara, Yoshihiko | ||||||||||
| PMID: | 12775012 | ||||||||||
| 24. | |||||||||||
| Journal: | Gastric Cancer. 2003;6 Suppl 1:66-70. | ||||||||||
| Title: | Dihydropyrimidine dehydrogenase (DPD) activity in gastric cancer tissue and effect of DPD inhibitory fluoropyrimidines. | ||||||||||
| Author: | Usuki, Hisashi|Ishimura, Ken|Yachida, Shinichi|Hagiike, Masanobu|Okano, Keiichi|Izuishi, Kunihiko|Karasawa, Yukihiko|Goda, Fuminori|Maeta, Hajime | ||||||||||
| PMID: | 12775023 | ||||||||||
| 25. | |||||||||||
| Journal: | Gastric Cancer. 2003;6 Suppl 1:71-81. | ||||||||||
| Title: | Prediction of sensitivity to fluoropyrimidines by metabolic and target enzyme activities in gastric cancer. | ||||||||||
| Author: | Terashima, Masanori|Fujiwara, Hisataka|Takagane, Akinori|Abe, Kaoru|Irinoda, Takashi|Nakaya, Tsutomu|Yonezawa, Hitoshi|Oyama, Kenichi|Saito, Kazuyoshi|Kanzaki, Norio|Ohtani, Satoshi|Nemoto, Tsuyoshi|Hoshino, Yutaka|Kogure, Michihiko|Gotoh, Mitsukazu | ||||||||||
| PMID: | 12775024 | ||||||||||
| 26. | |||||||||||
| Journal: | Gastric Cancer. 2003;6 Suppl 1:82-9. | ||||||||||
| Title: | Future prospects of personalized chemotherapy in gastric cancer patients: results of a prospective randomized pilot study. | ||||||||||
| Author: | Yoshida, Kazuhiro|Tanabe, Kazuaki|Ueno, Hideaki|Ohta, Kouji|Hihara, Jun|Toge, Tetsuya|Nishiyama, Masahiko | ||||||||||
| PMID: | 12775025 | ||||||||||
| 27. | |||||||||||
| Journal: | Suppl Tumori. 2003 Sep-Oct;2(5):S19-22. | ||||||||||
| Title: | Pharmacogenetics of stomach cancer. | ||||||||||
| Author: | Toffoli, Giuseppe|Cecchin, Erika | ||||||||||
| PMID: | 12914384 | ||||||||||
| 28. | |||||||||||
| Journal: | Br J Cancer. 2003 Sep 1;89(5):816-20. | ||||||||||
| Title: | Plasma concentrations of 5-fluorouracil and F-beta-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil. | ||||||||||
| Author: | Yamada, Y|Hamaguchi, T|Goto, M|Muro, K|Matsumura, Y|Shimada, Y|Shirao, K|Nagayama, S | ||||||||||
| PMID: | 12942110 | ||||||||||
| 29. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2003 Sep;30(9):1297-301. | ||||||||||
| Title: | [Efficacy and safety of novel oral fluoropyrimidine anticancer drug, TS-1 for advanced and recurrent gastric cancer patients]. | ||||||||||
| Author: | Arai, Kuniyoshi|Iwasaki, Yoshiaki|Kimura, Yutaka|Takahashi, Keiichi|Yamaguchi, Tatsuro|Honma, Shigenori|Takahashi, Toshio | ||||||||||
| PMID: | 14518409 | ||||||||||
| 30. | |||||||||||
| Journal: | Eur J Cancer. 2003 Nov;39(16):2387-94. | ||||||||||
| Title: | Superior antitumour activity of S-1 in tumours with a high dihydropyrimidine dehydrogenase activity. | ||||||||||
| Author: | Fujiwara, H|Terashima, M|Irinoda, T|Takagane, A|Abe, K|Nakaya, T|Yonezawa, H|Oyama, K|Takahashi, M|Saito, K|Takechi, T|Fukushima, M|Shirasaka, T | ||||||||||
| PMID: | 14556932 | ||||||||||
| 31. | |||||||||||
| Journal: | Oncol Rep. 2004 Jan;11(1):9-15. | ||||||||||
| Title: | Expression of thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase, E2F-1, Bak, Bcl-X, and Bcl-2, and clinical outcomes for gastric cancer patients treated with bolus 5-fluorouracil. | ||||||||||
| Author: | Tahara, Makoto|Ochiai, Atsuhi|Fujimoto, Junya|Boku, Narikazu|Yasui, Wataru|Ohtsu, Atsushi|Tahara, Eiichi|Yoshida, Shigeaki | ||||||||||
| PMID: | 14654896 | ||||||||||
| 32. | |||||||||||
| Journal: | Dig Dis Sci. 2004 Jan;49(1):60-4. | ||||||||||
| Title: | Differences in dihydropyrimidine dehydrogenase activities between gastric and colorectal cancer. | ||||||||||
| Author: | Nakata, Bunzo|Muguruma, Kazuya|Yamagata, Shigehito|Yukimoto, Kiyotaka|Maeda, Kiyoshi|Nishiguchi, Yukio|Ohira, Masaichi|Kato, Yasuyuki|Hirakawa, Kosei | ||||||||||
| PMID: | 14992436 | ||||||||||
| 33. | |||||||||||
| Journal: | Oncol Rep. 2004 May;11(5):1045-51. | ||||||||||
| Title: | Comparative analysis of thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in gastric and colorectal cancers. | ||||||||||
| Author: | Hotta, Tsukasa|Taniguchi, Katsutoshi|Kobayashi, Yasuhito|Johata, Kiyofumi|Sahara, Masaki|Naka, Teiji|Watanabe, Takashi|Ochiai, Minoru|Tanimura, Hiroshi|Tsubota, Yukari T | ||||||||||
| PMID: | 15069545 | ||||||||||
| 34. | |||||||||||
| Journal: | Oncol Rep. 2004 Jun;11(6):1233-9. | ||||||||||
| Title: | Preoperative endoscopic analysis of thymidine phosphorylase and dihydropyrimidine dehydrogenase in gastrointestinal cancer. | ||||||||||
| Author: | Hotta, Tsukasa|Taniguchi, Katsutoshi|Kobayashi, Yasuhito|Johata, Kiyofumi|Sahara, Masaki|Naka, Teiji|Watanabe, Takashi|Ochiai, Minoru|Tanimura, Hiroshi|Tsubota, Yukari T | ||||||||||
| PMID: | 15138561 | ||||||||||
| 35. | |||||||||||
| Journal: | Eur J Cancer. 2004 Jul;40(10):1566-71. | ||||||||||
| Title: | The ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase in tumour tissues of patients with metastatic gastric cancer is predictive of the clinical response to 5'-deoxy-5-fluorouridine. | ||||||||||
| Author: | Nishina, Tomohiro|Hyodo, Ichinosuke|Miyaike, Jiro|Inaba, Tomoki|Suzuki, Seiyuu|Shiratori, Yasushi | ||||||||||
| PMID: | 15196541 | ||||||||||
| 36. | |||||||||||
| Journal: | Gastric Cancer. 2004;7(2):110-6. | ||||||||||
| Title: | Changes in thymidylate synthase and its inhibition rate and changes in dihydropyrimidine dehydrogenase after the administration of 5-fluorouracil with cisplatin to nude mice with gastric cancer xenograft SC-1-NU. | ||||||||||
| Author: | Sakurai, Yoichi|Uraguchi, Takashi|Imazu, Hiroki|Hasegawa, Shigeru|Matsubara, Toshiki|Ochiai, Masahiro|Funabiki, Takahiko | ||||||||||
| PMID: | 15224198 | ||||||||||
| 37. | |||||||||||
| Journal: | Int J Cancer. 2004 Dec 20;112(6):967-73. | ||||||||||
| Title: | Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in relation to differentiation of gastric cancer. | ||||||||||
| Author: | Ichikawa, Wataru|Takahashi, Takehiro|Suto, Kenichi|Nihei, Zenro|Shirota, Yoshinori|Shimizu, Michio|Sasaki, Yasutsuna|Hirayama, Renzo | ||||||||||
| PMID: | 15316940 | ||||||||||
| 38. | |||||||||||
| Journal: | Anticancer Res. 2004 Jul-Aug;24(4):2455-63. | ||||||||||
| Title: | Thymidylate synthetase (TS) genotype and TS/dihydropyrimidine dehydrogenase mRNA level as an indicator in determining chemosensitivity to 5-fluorouracil in advanced gastric carcinoma. | ||||||||||
| Author: | Toriumi, Fumiki|Kubota, Tetsuro|Saikawa, Yoshiro|Yoshida, Masashi|Otani, Yoshihide|Watanabe, Masahiko|Kumai, Koichiro|Kitajima, Masaki | ||||||||||
| PMID: | 15330198 | ||||||||||
| 39. | |||||||||||
| Journal: | Anticancer Res. 2004 Jul-Aug;24(4):2495-501. | ||||||||||
| Title: | Expression of dihydropyrimidine dehydrogenase in cancer cells but not in stromal cells predicts the efficacy of fluorouracil treatment in patients with gastric carcinoma. | ||||||||||
| Author: | Hisamitsu, Kazunori|Tsujitani, Shunichi|Yamaguchi, Kenichi|Fukuda, Kenji|Konishi, Ichiro|Kaibara, Nobuaki | ||||||||||
| PMID: | 15330204 | ||||||||||
| 40. | |||||||||||
| Journal: | Br J Cancer. 2004 Oct 4;91(7):1245-50. | ||||||||||
| Title: | Thymidylate synthase predictive power is overcome by irinotecan combination therapy with S-1 for gastric cancer. | ||||||||||
| Author: | Ichikawa, W|Takahashi, T|Suto, K|Yamashita, T|Nihei, Z|Shirota, Y|Shimizu, M|Sasaki, Y|Hirayama, R | ||||||||||
| PMID: | 15354215 | ||||||||||
| 41. | |||||||||||
| Journal: | Oncol Rep. 2004 Nov;12(5):973-8. | ||||||||||
| Title: | Dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine S-1 may be effective against peritoneal dissemination in gastric cancer. | ||||||||||
| Author: | Yamagata, Shigehito|Nakata, Bunzo|Hirakawa, Kosei | ||||||||||
| PMID: | 15492780 | ||||||||||
| 42. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2005 Feb;32(2):183-7. | ||||||||||
| Title: | [Assessment of dihydropyrimidine dehydrogenase and thymidylate synthase expression in gastric carcinoma and colonic carcinoma]. | ||||||||||
| Author: | Yoshida, Toru|Shimooki, Osamu|Baba, Yuko|Abe, Tadashi|Sugai, Tamotsu|Nakamura, Shin-ichi | ||||||||||
| PMID: | 15751630 | ||||||||||
| 43. | |||||||||||
| Journal: | Clin Cancer Res. 2005 Apr 15;11(8):3025-31. | ||||||||||
| Title: | Combined GADD45A and thymidine phosphorylase expression levels predict response and survival of neoadjuvant-treated gastric cancer patients. | ||||||||||
| Author: | Napieralski, Rudolf|Ott, Katja|Kremer, Markus|Specht, Katja|Vogelsang, Holger|Becker, Karen|Muller, Martina|Lordick, Florian|Fink, Ulrich|Rudiger Siewert, Jorg|Hofler, Heinz|Keller, Gisela | ||||||||||
| PMID: | 15837757 | ||||||||||
| 44. | |||||||||||
| Journal: | Anticancer Res. 2005 Jul-Aug;25(4):2997-3001. | ||||||||||
| Title: | Clinical application of immunoreactivity of dihydropyrimidine dehydrogenase (DPD) in gastric scirrhous carcinoma treated with S-1, a new DPD inhibitory fluoropyrimidine. | ||||||||||
| Author: | Shimizu, Toshio|Yamada, Yasuhide|Yasui, Hisateru|Shirao, Kuniaki|Fukuoka, Masahiro | ||||||||||
| PMID: | 16080558 | ||||||||||
| 45. | |||||||||||
| Journal: | Onkologie. 2005 Nov;28(11):589-92. | ||||||||||
| Title: | Pharmacogenetics of extraordinary responses to 5-FU/cisplatin chemotherapy in advanced gastric cancer -- report of 2 cases. | ||||||||||
| Author: | Wolschke, Christine|Goekkurt, Eray|Al-Batran, Salah-Eddin|Hossfeld, Dieter Kurt|Stoehlmacher, Jan | ||||||||||
| PMID: | 16249645 | ||||||||||
| 46. | |||||||||||
| Journal: | J Exp Clin Cancer Res. 2005 Sep;24(3):457-62. | ||||||||||
| Title: | Level of 5-fluorodeoxyuridine 5'-monophosphate in cancerous tissue in patients with gastric cancer under preoperative administration of TS-1. A preliminary study. | ||||||||||
| Author: | Yamamoto, S|Kubota, K | ||||||||||
| PMID: | 16270533 | ||||||||||
| 47. | |||||||||||
| Journal: | Anticancer Res. 2005 Nov-Dec;25(6A):3755-61. | ||||||||||
| Title: | Expression levels of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) in patients with gastrointestinal cancer. | ||||||||||
| Author: | Nakayama, Yoshifumi|Inoue, Yuzuru|Nagashima, Nobuo|Katsuki, Takefumi|Matsumoto, Kentarou|Kadowaki, Koji|Shibao, Kazunori|Tsurudome, Yosuke|Hirata, Keiji|Sako, Tatsuhiko|Nagata, Naoki|Itoh, Hideaki | ||||||||||
| PMID: | 16302736 | ||||||||||
| 48. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2005 Oct;32(11):1748-51. | ||||||||||
| Title: | [A trial of TS-1 administration on the basis of the pharmacokinetic study for an advanced gastric cancer patient with impaired renal function]. | ||||||||||
| Author: | Yamamoto, Kazuyoshi|Imamura, Hiroshi|Furukawa, Hiroshi|Kishimoto, Tomono|Tanaka, Junichi|Oshiro, Ryota|Tatsuta, Masayuki|Masutani, Seizo|Fukunaga, Mutsumi|Nakayama, Takahiro|Takemoto, Hiroyoshi|Kondo, Motoi|Kamigaki, Shunji|Kawasaki, Takatoshi | ||||||||||
| PMID: | 16315929 | ||||||||||
| 49. | |||||||||||
| Journal: | Nagoya J Med Sci. 2005 Jun;67(3-4):117-24. | ||||||||||
| Title: | Polymorphism of dihydropyrimidine dehydrogenase (DPYD) Cys29Arg and risk of six malignancies in Japanese. | ||||||||||
| Author: | Tanaka, Daisuke|Hishida, Asahi|Matsuo, Keitaro|Iwata, Hiroji|Shinoda, Masayuki|Yamamura, Yoshitaka|Kato, Tomoyuki|Hatooka, Shunzo|Mitsudomi, Tetsuya|Kagami, Yoshitoyo|Ogura, Michinori|Tajima, Kazuo|Suyama, Motokazu|Naito, Mariko|Yamamoto, Kazuhito|Tamakos | ||||||||||
| PMID: | 17375478 | ||||||||||
| 50. | |||||||||||
| Journal: | Int J Cancer. 2006 Aug 15;119(4):783-91. | ||||||||||
| Title: | Synergistic effects of docetaxel and S-1 by modulating the expression of metabolic enzymes of 5-fluorouracil in human gastric cancer cell lines. | ||||||||||
| Author: | Wada, Yoshiyuki|Yoshida, Kazuhiro|Suzuki, Takahisa|Mizuiri, Hirozumi|Konishi, Kazuo|Ukon, Kei|Tanabe, Kazuaki|Sakata, Yu|Fukushima, Masakazu | ||||||||||
| PMID: | 16557585 | ||||||||||
| 51. | |||||||||||
| Journal: | Anticancer Res. 2006 Mar-Apr;26(2B):1455-62. | ||||||||||
| Title: | A phase I study of bi-weekly combination therapy with S-1 and docetaxel for advanced or recurrent gastric cancer. | ||||||||||
| Author: | Rino, Yasushi|Takanashi, Yoshinori|Yukawa, Norio|Saeki, Hiroyuki|Wada, Hiroo|Kanari, Masahiro|Yamada, Roppei|Satoh, Tsutomu|Yamamoto, Naoto|Imada, Toshio | ||||||||||
| PMID: | 16619558 | ||||||||||
| 52. | |||||||||||
| Journal: | Korean J Intern Med. 2006 Mar;21(1):43-5. | ||||||||||
| Title: | Unpredicted severe toxicity after 5-fluorouracil treatment due to dihydropyrimidine dehydrogenase deficiency. | ||||||||||
| Author: | Baek, Jin Ho|Kim, Jong Gwang|Kim, Shi Nae|Kim, Dong Hwan|Sohn, Sang Kyun|Hong, Young Jun|Lee, Kyu Bo | ||||||||||
| PMID: | 16646564 | ||||||||||
| 53. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2006 May;33(5):625-9. | ||||||||||
| Title: | [Thymidylate synthase and dihydropyrimidine dehydrogenase expression and histological effects of preoperative UFT in gastric cancer patients]. | ||||||||||
| Author: | Uyama, Ryo|Yoshizawa, Yasuo|Tajiri, Takuma|Endo, Yutaka|Mitsuya, Toshiyuki|Sanada, Yutaka | ||||||||||
| PMID: | 16685161 | ||||||||||
| 54. | |||||||||||
| Journal: | Int J Cancer. 2006 Oct 15;119(8):1927-33. | ||||||||||
| Title: | Simple combinations of 5-FU pathway genes predict the outcome of metastatic gastric cancer patients treated by S-1. | ||||||||||
| Author: | Ichikawa, Wataru|Takahashi, Takehiro|Suto, Kenichi|Shirota, Yoshinori|Nihei, Zenro|Shimizu, Michio|Sasaki, Yasutsuna|Hirayama, Renzo | ||||||||||
| PMID: | 16736497 | ||||||||||
| 55. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2006 Jun;33 Suppl 1:37-41. | ||||||||||
| Title: | [Plasma concentrations of 5-fluorouracil and F-beta-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil]. | ||||||||||
| Author: | Yamada, Yasuhide | ||||||||||
| PMID: | 16897970 | ||||||||||
| 56. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2006 Jun;33 Suppl 1:83-6. | ||||||||||
| Title: | [Combination chemotherapy of S-1 and docetaxel on advanced and recurrent gastric cancer]. | ||||||||||
| Author: | Yoshida, Kazuhiro|Wada, Yoshiyuki|Tanabe, Kazuaki|Ukon, Kei|Hihara, Jyun | ||||||||||
| PMID: | 16897978 | ||||||||||
| 57. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2006 Jun;33 Suppl 1:117-20. | ||||||||||
| Title: | Rapid development of S-1 in the west for therapy of advanced gastric carcinoma. | ||||||||||
| Author: | Ajani, Jaffer A | ||||||||||
| PMID: | 16897985 | ||||||||||
| 58. | |||||||||||
| Journal: | Ai Zheng. 2006 Aug;25(8):1039-43. | ||||||||||
| Title: | [Correlative analysis between serum dihydropyrimidine dehydrogenase, activity, concentration of 5-fluorouracil and adverse events in the treatment of advanced gastric cancer patients]. | ||||||||||
| Author: | Peng, Rou-Jun|Dong, Qiu-Mei|Shi, Yan-Xia|Cao, Ye|Zhou, Zhong-Mei|Yuan, Zhong-Yu|Li, Su|Li, Hai|Jiang, Wen-Qi | ||||||||||
| PMID: | 16965690 | ||||||||||
| 59. | |||||||||||
| Journal: | Oncol Rep. 2006 Oct;16(4):721-7. | ||||||||||
| Title: | Expression of chemoresistance-related proteins in alpha-fetoprotein-producing adenocarcinoma of the digestive organs. | ||||||||||
| Author: | Kamoshida, Shingo|Suzuki, Mai|Sakurai, Yoichi|Ochiai, Masahiro|Kimura, Fumikazu|Kuwao, Sadahito|Sakamoto, Kazuki|Sugimoto, Yoshikazu|Fukushima, Masakazu|Tsutsumi, Yutaka | ||||||||||
| PMID: | 16969485 | ||||||||||
| 60. | |||||||||||
| Journal: | Oncol Rep. 2006 Dec;16(6):1165-72. | ||||||||||
| Title: | The expression profiles of orotate phosphoribosyltransferase and dihydropyrimidine dehydrogenase in gastric cancer and their clinical significance. | ||||||||||
| Author: | Oeda, Mamoru|Yoshida, Kazuhiro|Sanada, Yuichi|Wada, Yoshiyuki|Suzuki, Takahisa|Mizuiri, Hirozumi|Konishi, Kazuo|Shigematsu, Hideo|Tanabe, Kazuaki|Fukushima, Masakazu | ||||||||||
| PMID: | 17089033 | ||||||||||
| 61. | |||||||||||
| Journal: | Adv Exp Med Biol. 2006;587:115-20. | ||||||||||
| Title: | Prediction of response to neoadjuvant chemotherapy in carcinomas of the upper gastrointestinal tract. | ||||||||||
| Author: | Hofler, Heinz|Langer, Rupert|Ott, Katja|Keller, Gisela | ||||||||||
| PMID: | 17163161 | ||||||||||
| 62. | |||||||||||
| Journal: | Cancer Lett. 2007 Jul 18;252(2):307-13. Epub 2007 Feb 15. | ||||||||||
| Title: | Gene expression of 5-fluorouracil metabolic enzymes in primary gastric cancer: correlation with drug sensitivity against 5-fluorouracil. | ||||||||||
| Author: | Kodera, Yasuhiro|Ito, Seiji|Fujiwara, Michitaka|Mochizuki, Yoshinari|Nakayama, Goro|Ohashi, Norifumi|Koike, Masahiko|Yamamura, Yoshitaka|Nakao, Akimasa | ||||||||||
| PMID: | 17303323 | ||||||||||
| 63. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2007 Aug;60(3):437-46. | ||||||||||
| Title: | Correlation between thymidylate synthase and dihydropyrimidine dehydrogenase mRNA level and in vitro chemosensitivity to 5-fluorouracil, in relation to differentiation in gastric cancer. | ||||||||||
| Author: | Fakhrejahani, Elham|Miyamoto, Akiko|Tanigawa, Nobuhiko | ||||||||||
| PMID: | 17377791 | ||||||||||
| 64. | |||||||||||
| Journal: | Zhonghua Nei Ke Za Zhi. 2007 Feb;46(2):103-6. | ||||||||||
| Title: | [The association between DPYD gene polymorphism and chemotherapeutic toxicity of 5-FU in gastric carcinoma and colonic carcinoma]. | ||||||||||
| Author: | Zhang, Hong|Li, You-ming|Yu, Chao-hui|Wang, Sheng-qi|Ji, Feng|Chen, Chun-xiao | ||||||||||
| PMID: | 17445431 | ||||||||||
| 65. | |||||||||||
| Journal: | Med Oncol. 2007;24(2):251-8. | ||||||||||
| Title: | DPYD*5 gene mutation contributes to the reduced DPYD enzyme activity and chemotherapeutic toxicity of 5-FU: results from genotyping study on 75 gastric carcinoma and colon carcinoma patients. | ||||||||||
| Author: | Zhang, Hong|Li, You-ming|Zhang, Hao|Jin, Xi | ||||||||||
| PMID: | 17848752 | ||||||||||
| 66. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2007 Oct;34(10):1581-7. | ||||||||||
| Title: | [Orotate phosphoribosyltransferase levels in gastric carcinoma and normal gastric mucosa - correlation with thymidylate synthase and dihydropyrimidine dehydrogenase levels and the changes after neoadjuvant chemotherapy]. | ||||||||||
| Author: | Sakurai, Yoichi|Furuta, Shinpei|Sunagawa, Risaburo|Tonomura, Shuhei|Inaba, Kazuki|Shoji, Mitsutaka|Nakamura, Yasuko|Isogaki, Jun|Komori, Yoshiyuki|Uyama, Ichiro|Kamoshida, Shingo|Tsutsumi, Yutaka | ||||||||||
| PMID: | 17940372 | ||||||||||
| 67. | |||||||||||
| Journal: | J Gastroenterol. 2007 Oct;42(10):816-22. | ||||||||||
| Title: | Synergistic antitumor effect of combined 5-fluorouracil (5-FU) with 5-chloro-2,4-dihydroxypyridine on 5-FU-resistant gastric cancer cells: possible role of a dihydropyrimidine dehydrogenase-independent mechanism. | ||||||||||
| Author: | Sasaki, Eiji|Tominaga, Kazunari|Kuwamura, Hikaru|Watanabe, Toshio|Fujiwara, Yasuhiro|Oshitani, Nobuhide|Higuchi, Kazuhide|Arakawa, Tetsuo | ||||||||||
| PMID: | 17940834 | ||||||||||
| 68. | |||||||||||
| Journal: | Gastrointest Cancer Res. 2007 Sep;1(5):171-6. | ||||||||||
| Title: | Thymidylate synthase gene expression in primary tumors predicts activity of s-1-based chemotherapy for advanced gastric cancer. | ||||||||||
| Author: | Takiuchi, Hiroya|Kawabe, Shin-Ichiro|Gotoh, Masahiro|Katsu, Ken-Ichi | ||||||||||
| PMID: | 19262706 | ||||||||||
| 69. | |||||||||||
| Journal: | Br J Cancer. 2008 Feb 26;98(4):832-9. | ||||||||||
| Title: | Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer. | ||||||||||
| Author: | Matsubara, J|Nishina, T|Yamada, Y|Moriwaki, T|Shimoda, T|Kajiwara, T|Nakajima, T E|Kato, K|Hamaguchi, T|Shimada, Y|Okayama, Y|Oka, T|Shirao, K | ||||||||||
| PMID: | 18231104 | ||||||||||
| 70. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2008 Dec;63(1):85-9. | ||||||||||
| Title: | High intratumoral dihydropyrimidine dehydrogenase mRNA levels in pancreatic cancer associated with a high rate of response to S-1. | ||||||||||
| Author: | Kuramochi, Hidekazu|Hayashi, Kazuhiko|Uchida, Kazumi|Nakajima, Go|Hatori, Takashi|Danenberg, Kathleen D|Danenberg, Peter V|Yamamoto, Masakazu | ||||||||||
| PMID: | 18309485 | ||||||||||
| 71. | |||||||||||
| Journal: | Ann Surg Oncol. 2008 Aug;15(8):2301-9. | ||||||||||
| Title: | Effects of combined administration of DPD-inhibitory oral fluoropyrimidine, S-1, plus paclitaxel on gene expressions of fluoropyrimidine metabolism-related enzymes in human gastric xenografts. | ||||||||||
| Author: | Sakurai, Yoichi|Yoshida, Ikuo|Kamoshida, Shingo|Inaba, Kazuki|Isogaki, Jun|Komori, Yoshiyuki|Uyama, Ichiro|Tsutsumi, Yutaka | ||||||||||
| PMID: | 18506536 | ||||||||||
| 72. | |||||||||||
| Journal: | J Surg Oncol. 2008 Aug 1;98(2):130-4. | ||||||||||
| Title: | Dihydropyrimidine dehydrogenases and cytidine-deaminase gene polymorphisms as outcome predictors in resected gastric cancer patients treated with fluoropyrimidine adjuvant chemotherapy. | ||||||||||
| Author: | Grau, Juan J|Caballero, Miguel|Monzo, Mariano|Munoz-Garcia, Carmen|Domingo-Domenech, Jose|Navarro, Alfons|Conill, Carlos|Campayo, Marc|Bombi, Jose A | ||||||||||
| PMID: | 18537153 | ||||||||||
| 73. | |||||||||||
| Journal: | Int J Clin Oncol. 2008 Jun;13(3):212-9. | ||||||||||
| Title: | Challenge for a better combination with basic evidence. | ||||||||||
| Author: | Yoshida, Kazuhiro|Yamaguchi, Kazuya|Osada, Shinji|Kawaguchi, Yoshihiro|Takahashi, Takao|Sakashita, Fumio|Tanaka, Yoshihiro | ||||||||||
| PMID: | 18553230 | ||||||||||
| 74. | |||||||||||
| Journal: | Anticancer Res. 2008 May-Jun;28(3A):1593-602. | ||||||||||
| Title: | Changes of gene expression of thymidine phosphorylase, thymidylate synthase, dihydropyrimidine dehydrogenase after the administration of 5'-deoxy-5-fluorouridine, paclitaxel and its combination in human gastric cancer xenografts. | ||||||||||
| Author: | Sakurai, Yoichi|Yoshida, Ikuo|Kamoshida, Shingo|Inaba, Kazuki|Isogaki, Jun|Komori, Yoshiyuki|Uyama, Ichiro|Tsutsumi, Yutaka | ||||||||||
| PMID: | 18630517 | ||||||||||
| 75. | |||||||||||
| Journal: | Anticancer Drugs. 2008 Sep;19(8):819-24. | ||||||||||
| Title: | Prediction of the effect of capecitabine in gastric cancer by immunohistochemical staining of thymidine phosphorylase and dihydropyrimidine dehydrogenase. | ||||||||||
| Author: | Koizumi, Wasaburo|Okayasu, Isao|Hyodo, Ichinosuke|Sakamoto, Junichi|Kojima, Hiroshi | ||||||||||
| PMID: | 18690094 | ||||||||||
| 76. | |||||||||||
| Journal: | Int J Mol Med. 2008 Dec;22(6):709-16. | ||||||||||
| Title: | Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis. | ||||||||||
| Author: | Fukui, Yousuke|Oka, Toshinori|Nagayama, Sekio|Danenberg, Peter V|Danenberg, Kathleen D|Fukushima, Masakazu | ||||||||||
| PMID: | 19020767 | ||||||||||
| 77. | |||||||||||
| Journal: | Hepatogastroenterology. 2008 Sep-Oct;55(86-87):1882-6. | ||||||||||
| Title: | The discrepancy in thymidylate synthase and dihydropyrimidine dehydrogenase expression depending on measurement methodologies in stage 4 gastric cancer. | ||||||||||
| Author: | Akamoto, Shintaro|Usuki, Hisashi|Haba, Reiji|Kakinoki, Keitarou|Okano, Keiichi|Izuishi, Kunihiko|Wakabayashi, Hisao|Suzuki, Yasuyuki | ||||||||||
| PMID: | 19102414 | ||||||||||
| 78. | |||||||||||
| Journal: | Toxicology. 2009 Feb 4;256(1-2):135-40. | ||||||||||
| Title: | Synergistic effect of 5-fluorouracil with gambogic acid on BGC-823 human gastric carcinoma. | ||||||||||
| Author: | Wang, Jun|Liu, Wei|Zhao, Qing|Qi, Qi|Lu, Na|Yang, Yong|Nei, Fei-Fei|Rong, Jing-Jing|You, Qi-Dong|Guo, Qing-Long | ||||||||||
| PMID: | 19084572 | ||||||||||
| 79. | |||||||||||
| Journal: | Int J Oncol. 2009 Mar;34(3):787-96. | ||||||||||
| Title: | Copy number changes can be a predictor for hemoglobin reduction after S-1 monotherapy in gastric cancer. | ||||||||||
| Author: | Jeung, Hei Cheul|Rha, Sun Young|Park, Chan Hee|Im, Chong-Kun|Shin, Sang Joon|Ahn, Joong Bae|Noh, Sung Hoon|Roh, Jae Kyung|Chung, Hyun Cheol | ||||||||||
| PMID: | 19212683 | ||||||||||
| 80. | |||||||||||
| Journal: | Br J Cancer. 2009 Mar 10;100(5):732-8. | ||||||||||
| Title: | Biomarker analysis in stage III-IV (M0) gastric cancer patients who received curative surgery followed by adjuvant 5-fluorouracil and cisplatin chemotherapy: epidermal growth factor receptor (EGFR) associated with favourable survival. | ||||||||||
| Author: | Kim, J-S|Kim, M-A|Kim, T M|Lee, S-H|Kim, D-W|Im, S-A|Kim, T-Y|Kim, W H|Yang, H-K|Heo, D S|Bang, Y-J|Lee, K-U|Choe, K-J|Kim, N K | ||||||||||
| PMID: | 19259093 | ||||||||||
| 81. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2010 Jan;37(1):131-3. | ||||||||||
| Title: | [Severe bone marrow suppression during adjuvant chemotherapy for gastric cancer by S-1 and its possible relationship to dihydropyrimidine dehydrogenase deficiency]. | ||||||||||
| Author: | Aragane, Hideki|Suchi, Kentaro|Shimomura, Masanori|Katano, Tomoko|Yasui, Hitoshi|Kan, Keitaro | ||||||||||
| PMID: | 20087047 | ||||||||||
| 82. | |||||||||||
| Journal: | Toxicol Lett. 2010 Sep 1;197(3):201-10. | ||||||||||
| Title: | Wogonin potentiates the antitumor effects of low dose 5-fluorouracil against gastric cancer through induction of apoptosis by down-regulation of NF-kappaB and regulation of its metabolism. | ||||||||||
| Author: | Zhao, Qing|Wang, Jia|Zou, Mei-Juan|Hu, Rong|Zhao, Li|Qiang, Lei|Rong, Jing-Jing|You, Qi-Dong|Guo, Qing-Long | ||||||||||
| PMID: | 20570612 | ||||||||||
| 83. | |||||||||||
| Journal: | Cancer Res Treat. 2010 Jun;42(2):118-20. | ||||||||||
| Title: | |||||||||||