Literatures

Primary Site >> Colorectal Cancer

Gene >> DPYD

1.
Journal:	J Clin Oncol. 1997 Jan;15(1):389-400.
Title:	Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors.
Author:	Rustum, Y M\|Harstrick, A\|Cao, S\|Vanhoefer, U\|Yin, M B\|Wilke, H\|Seeber, S
PMID:	8996166

2.
Journal:	Br J Cancer. 1998;77(3):461-5.
Title:	Characterization of dihydropyrimidine dehydrogenase in human colorectal tumours.
Author:	McLeod, H L\|Sludden, J\|Murray, G I\|Keenan, R A\|Davidson, A I\|Park, K\|Koruth, M\|Cassidy, J
PMID:	9472644

3.
Journal:	Br J Cancer. 1998;77(3):497-500.
Title:	Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer.
Author:	Ridge, S A\|Sludden, J\|Wei, X\|Sapone, A\|Brown, O\|Hardy, S\|Canney, P\|Fernandez-Salguero, P\|Gonzalez, F J\|Cassidy, J\|McLeod, H L
PMID:	9472650

4.
Journal:	Oncology. 1998 Sep-Oct;55(5):468-74.
Title:	Putative role of dihydropyrimidine dehydrogenase in the toxic side effect of 5-fluorouracil in colorectal cancer patients.
Author:	Katona, C\|Kralovanszky, J\|Rosta, A\|Pandi, E\|Fonyad, G\|Toth, K\|Jeney, A
PMID:	9732227

5.
Journal:	Oncology (Williston Park). 1998 Oct;12(10 Suppl 7):52-6.
Title:	Clinical development of eniluracil: current status.
Author:	Hohneker, J A
PMID:	9830627

6.
Journal:	Eur J Cancer. 1998 Sep;34(10):1623-7.
Title:	Autoregulation of 5-fluorouracil metabolism.
Author:	McLeod, H L\|Sludden, J\|Hardy, S C\|Lock, R E\|Hawksworth, G M\|Cassidy, J
PMID:	9893640

7.
Journal:	Hepatogastroenterology. 1998 Nov-Dec;45(24):2117-22.
Title:	Dihydropyrimidine dehydrogenase but not thymidylate synthase expression is associated with resistance to 5-fluorouracil in colorectal cancer.
Author:	Nita, M E\|Tominaga, O\|Nagawa, H\|Tsuruo, T\|Muto, T
PMID:	9951876

8.
Journal:	Cancer Invest. 1999;17(3):201-5.
Title:	Prolonged severe 5-fluorouracil-associated neurotoxicity in a patient with dihydropyrimidine dehydrogenase deficiency.
Author:	Shehata, N\|Pater, A\|Tang, S C
PMID:	10099659

9.
Journal:	Clin Cancer Res. 1999 Apr;5(4):883-9.
Title:	Dihydropyrimidine dehydrogenase activity and messenger RNA level may be related to the antitumor effect of 5-fluorouracil on human tumor xenografts in nude mice.
Author:	Ishikawa, Y\|Kubota, T\|Otani, Y\|Watanabe, M\|Teramoto, T\|Kumai, K\|Kitajima, M\|Takechi, T\|Okabe, H\|Fukushima, M
PMID:	10213225

10.
Journal:	Oncology. 1999 Jul;57 Suppl 1:2-8.
Title:	Fluoropyrimidines: a critical evaluation.
Author:	Brito, R A\|Medgyesy, D\|Zukowski, T H\|Royce, M E\|Ravandi-Kashani, F\|Hoff, P M\|Pazdur, R
PMID:	10436410

11.
Journal:	Clin Cancer Res. 1999 Aug;5(8):2000-5.
Title:	Pharmacokinetic study of S-1, a novel oral fluorouracil antitumor drug.
Author:	Hirata, K\|Horikoshi, N\|Aiba, K\|Okazaki, M\|Denno, R\|Sasaki, K\|Nakano, Y\|Ishizuka, H\|Yamada, Y\|Uno, S\|Taguchi, T\|Shirasaka, T
PMID:	10473078

12.
Journal:	Clin Cancer Res. 1999 Sep;5(9):2566-70.
Title:	Regulation of dihydropyrimidine dehydrogenase in colorectal cancer.
Author:	Johnston, S J\|Ridge, S A\|Cassidy, J\|McLeod, H L
PMID:	10499634

13.
Journal:	Clin Cancer Res. 1999 Oct;5(10):2836-9.
Title:	Relationship between intratumoral dihydropyrimidine dehydrogenase activity and gene expression in human colorectal cancer.
Author:	Uetake, H\|Ichikawa, W\|Takechi, T\|Fukushima, M\|Nihei, Z\|Sugihara, K
PMID:	10537350

14.
Journal:	Gan To Kagaku Ryoho. 1999 Oct;26(12):1729-31.
Title:	[Dihydropyrimidine dehydrogenase gene expression in patients with hepatic metastases from colorectal cancer].
Author:	Shirota, Y\|Ichikawa, W\|Yamada, H\|Uetake, H\|Nihei, Z\|Sugihara, K
PMID:	10560382

15.
Journal:	J Clin Oncol. 1999 Aug;17(8):2439-45.
Title:	Eniluracil treatment completely inactivates dihydropyrimidine dehydrogenase in colorectal tumors.
Author:	Ahmed, F Y\|Johnston, S J\|Cassidy, J\|O'Kelly, T\|Binnie, N\|Murray, G I\|van Gennip, A H\|Abeling, N G\|Knight, S\|McLeod, H L
PMID:	10561307

16.
Journal:	Am J Health Syst Pharm. 1999 Dec 1;56(23):2417-28; quiz 2428-9.
Title:	Novel oral fluoropyrimidines in the treatment of metastatic colorectal cancer.
Author:	Ignoffo, R J
PMID:	10595802

17.
Journal:	Semin Oncol. 1999 Dec;26(6):640-6.
Title:	Oral fluoropoyrimidines.
Author:	Hoff, P M\|Royce, M\|Medgyesy, D\|Brito, R\|Pazdur, R
PMID:	10606257

18.
Journal:	Clin Cancer Res. 1999 Dec;5(12):3948-55.
Title:	Phase I and pharmacokinetic study of tomudex combined with 5-fluorouracil plus levofolinic acid in advanced head and neck cancer and colorectal cancer.
Author:	Caponigro, F\|Avallone, A\|McLeod, H\|Carteni, G\|De Vita, F\|Casaretti, R\|Morsman, J\|Blackie, R\|Budillon, A\|De Lucia, L\|Gravina, A\|Catalano, G\|Comella, P\|Comella, G
PMID:	10632324

19.
Journal:	J Infect Chemother. 1999 Sep;5(3):144-148.
Title:	Pyrimidine nucleoside phosphorylase and dihydropyrimidine dehydrogenase indicate chemosensitivity of human colon cancer specimens to doxifluridine and 5-fluorouracil, respectively.
Author:	Kobayashi, Naoyuki\|Kubota, T.\|Watanabe, Masahiko\|Otani, Yoshihide\|Teramoto, Tatsuo\|Kitajima, Masaki
PMID:	11810506

20.
Journal:	Methods Mol Med. 1999;28:111-20.
Title:	5-Fluorouracil metabolizing enzymes.
Author:	McLeod, H L\|Milne, L H\|Johnston, S J
PMID:	21374032

21.
Journal:	Anal Biochem. 2000 Feb 15;278(2):175-84.
Title:	Quantitation of dihydropyrimidine dehydrogenase expression by real-time reverse transcription polymerase chain reaction.
Author:	Johnson, M R\|Wang, K\|Smith, J B\|Heslin, M J\|Diasio, R B
PMID:	10660460

22.
Journal:	Eur J Cancer. 2000 Mar;36(5):559-66.
Title:	New directions in the treatment of colorectal cancer: a look to the future.
Author:	Sobrero, A\|Kerr, D\|Glimelius, B\|Van Cutsem, E\|Milano, G\|Pritchard, D M\|Rougier, P\|Aapro, M
PMID:	10738119

23.
Journal:	Cancer Chemother Pharmacol. 2000;45(4):291-7.
Title:	Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients.
Author:	Schuller, J\|Cassidy, J\|Dumont, E\|Roos, B\|Durston, S\|Banken, L\|Utoh, M\|Mori, K\|Weidekamm, E\|Reigner, B
PMID:	10755317

24.
Journal:	Clin Cancer Res. 2000 Apr;6(4):1322-7.
Title:	Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.
Author:	Salonga, D\|Danenberg, K D\|Johnson, M\|Metzger, R\|Groshen, S\|Tsao-Wei, D D\|Lenz, H J\|Leichman, C G\|Leichman, L\|Diasio, R B\|Danenberg, P V
PMID:	10778957

25.
Journal:	Ann Oncol. 2000 Mar;11(3):273-9.
Title:	Characterization of dihydropyrimidine dehydrogenase on immunohistochemistry in colon carcinoma, and correlation between immunohistochemical score and protein level or messenger RNA expression.
Author:	Takenoue, T\|Kitayama, J\|Takei, Y\|Umetani, N\|Matsuda, K\|Nita, M E\|Hatano, K\|Tsuruo, T\|Nagawa, H
PMID:	10811492

26.
Journal:	Cancer Chemother Pharmacol. 2000;45(6):477-82.
Title:	Dihydropyrimidine dehydrogenase activity in normal, inflammatory and tumour tissues of colon and liver in humans.
Author:	Guimbaud, R\|Guichard, S\|Dusseau, C\|Bertrand, V\|Aparicio, T\|Lochon, I\|Chatelut, E\|Couturier, D\|Bugat, R\|Chaussade, S\|Canal, P
PMID:	10854135

27.
Journal:	Presse Med. 2000 May 27-Jun 3;29(19):1072-7.
Title:	[Metastatic colorectal cancer: new therapeutics].
Author:	Paule, B\|Brion, N
PMID:	10874920

28.
Journal:	Br J Cancer. 2000 Jul;83(2):141-5.
Title:	Phase II study of S-1, a novel oral fluorophyrimidine derivative, in patients with metastatic colorectal carcinoma. S-1 Cooperative Colorectal Carcinoma Study Group.
Author:	Ohtsu, A\|Baba, H\|Sakata, Y\|Mitachi, Y\|Horikoshi, N\|Sugimachi, K\|Taguchi, T
PMID:	10901361

29.
Journal:	Gan To Kagaku Ryoho. 2000 Aug;27(9):1415-20.
Title:	[Analysis of the salvage synthesis within biosynthesis of nucleic acid route in colon cancer].
Author:	Katsumata, K\|Sumi, T\|Murohashi, T\|Nagashima, K\|Uda, O\|Ashizawa, T\|Yamamoto, K\|Koyanagi, Y
PMID:	10969598

30.
Journal:	Expert Opin Investig Drugs. 2000 Jul;9(7):1635-49.
Title:	Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase.
Author:	Schilsky, R L\|Kindler, H L
PMID:	11060767

31.
Journal:	Invest New Drugs. 2000 Nov;18(4):331-42.
Title:	The tegafur-based dihydropyrimidine dehydrogenase inhibitory fluoropyrimidines, UFT/leucovorin (ORZEL) and S-1: a review of their clinical development and therapeutic potential.
Author:	Hoff, P M
PMID:	11081569

32.
Journal:	Invest New Drugs. 2000 Nov;18(4):373-81.
Title:	Pharmacology of fluorinated pyrimidines: eniluracil.
Author:	Baker, S D
PMID:	11081573

33.
Journal:	Gan To Kagaku Ryoho. 2000 Oct;27(12):1879-82.
Title:	[Clinical significance of determinations of dihydropyrimidine dehydrogenase levels in primary and hepatic lesions of colorectal cancer patients].
Author:	Ishida, H\|Hashimoto, D\|Inokuma, S\|Takeuchi, I\|Nakada, H\|Ohsawa, T\|Hoshino, T\|Murata, N\|Fujioka, M\|Idezuki, Y
PMID:	11086435

34.
Journal:	Gan To Kagaku Ryoho. 2000 Oct;27(12):1883-5.
Title:	[Thymidylate synthase and dihydropyrimidine dehydrogenase activity in a metastatic liver tumor from colorectal cancer].
Author:	Umekita, N\|Tanaka, S\|Abe, H\|Kitamura, M
PMID:	11086436

35.
Journal:	Oncology (Williston Park). 2000 Oct;14(10 Suppl 9):35-7.
Title:	Impact of UFT on tumoral TS and DPD levels in colorectal cancer.
Author:	Bastian, G\|Seitz, J F\|Moutardier, V\|Delperro, J R\|Fargeot, P\|Fraisse, J\|Formento, P\|Chazard, M\|Renee, N\|Milano, G
PMID:	11098489

36.
Journal:	Curr Oncol Rep. 2001 Mar;3(2):102-8.
Title:	Determinants of prognosis and response to therapy in colorectal cancer.
Author:	Iqbal, S\|Lenz, H J
PMID:	11177741

37.
Journal:	Oncology (Williston Park). 2001 Jan;15(1 Suppl 2):49-56.
Title:	UFT in the treatment of colorectal and breast cancer.
Author:	Sun, W\|Haller, D
PMID:	11219978

38.
Journal:	Cancer. 2001 Apr 1;91(7):1256-63.
Title:	Phase II study of oral eniluracil, 5-fluorouracil, and leucovorin in patients with advanced colorectal carcinoma.
Author:	Meropol, N J\|Niedzwiecki, D\|Hollis, D\|Schilsky, R L\|Mayer, R J
PMID:	11283924

39.
Journal:	Oncol Rep. 2001 May-Jun;8(3):621-5.
Title:	Dihydropyrimidine dehydrogenase activity of cancerous and non-cancerous tissues in liver and large intestine.
Author:	Ikeguchi, M\|Hirooka, Y\|Makino, M\|Kaibara, N
PMID:	11295091

40.
Journal:	Jpn J Clin Oncol. 2001 Feb;31(2):65-8.
Title:	Clinical relevance of the concentrations of both pyrimidine nucleoside phosphorylase (PyNPase) and dihydropyrimidine dehydrogenase (DPD) in colorectal cancer.
Author:	Hiroyasu, S\|Shiraishi, M\|Samura, H\|Tokashiki, H\|Shimoji, H\|Isa, T\|Muto, Y
PMID:	11302344

41.
Journal:	Gan To Kagaku Ryoho. 2001 May;28(5):655-60.
Title:	[Relationship between the anti-metastatic effect of UFT and in vitro chemosensitivity to 5-FU in metastatic tumors from orthotopic implanted colon cancer in nude rats].
Author:	Ogata, Y\|Akagi, Y\|Nozoe, Y\|Sasatomi, T\|Miyagi, Y\|Nakagawa, M\|Matono, K\|Kobayashi, H\|Shirouzu, K
PMID:	11383214

42.
Journal:	Gan To Kagaku Ryoho. 2001 May;28(5):661-7.
Title:	[Correlation between 5-fluorouracil (5-FU) sensitivity as measured by collagen gel droplet embedded culture drug sensitivity test (CD-DST) and expression of orotate phosphoribosyl transferase (OPRT), thymidylate synthase (TS), and dihydropyrimidine dehydr
Author:	Ochiai, T\|Sugitani, M\|Nishimura, K\|Noguchi, H\|Watanabe, T\|Sengoku, H\|Kihara, A\|Okano, M
PMID:	11383215

43.
Journal:	Gan To Kagaku Ryoho. 2001 Jun;28(6):809-14.
Title:	[Tumoral levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in elderly colorectal cancer patients].
Author:	Ishida, H\|Takeuchi, I\|Inokuma, S\|Nakada, H\|Ohsawa, T\|Hoshino, T\|Murata, N\|Fujioka, M\|Hashimoto, D\|Idezuki, Y
PMID:	11432349

44.
Journal:	Int J Oncol. 2001 Aug;19(2):341-6.
Title:	Changes in intratumoral thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) mRNA expression in colorectal and gastric cancer during continuous tegafur infusion.
Author:	Uchida, K\|Hayashi, K\|Kuramochi, H\|Takasaki, K
PMID:	11445849

45.
Journal:	Kurume Med J. 2001;48(2):93-8.
Title:	Dihydropyrimidine dehydrogenase activity and thymidylate synthase level are associated with response to 5-fluorouracil in human colorectal cancer.
Author:	Araki, Y\|Isomoto, H\|Shirouzu, K
PMID:	11501504

46.
Journal:	Clin Cancer Res. 2001 Sep;7(9):2783-7.
Title:	Variations in 5-fluorouracil concentrations of colorectal tissues as compared with dihydropyrimidine dehydrogenase (DPD) enzyme activities and DPD messenger RNA levels.
Author:	Tanaka-Nozaki, M\|Onda, M\|Tanaka, N\|Kato, S
PMID:	11555593

47.
Journal:	Clin Cancer Res. 2001 Sep;7(9):2832-9.
Title:	Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5'-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)- related toxicity compared with controls.
Author:	Raida, M\|Schwabe, W\|Hausler, P\|Van Kuilenburg, A B\|Van Gennip, A H\|Behnke, D\|Hoffken, K
PMID:	11555601

48.
Journal:	Cancer Biother Radiopharm. 2001 Aug;16(4):317-22.
Title:	Serum factors attenuating the anti-tumor activity of 5-fluorouracil.
Author:	Miwa, M\|Kojima, T\|Naruse, T
PMID:	11603002

49.
Journal:	Int J Cancer. 2001 Oct 15;94(2):297-301.
Title:	Thymidine phosphorylase and dihydropyrimidine dehydrogenase protein expression in colorectal cancer.
Author:	Collie-Duguid, E S\|Johnston, S J\|Boyce, L\|Smith, N\|Cowieson, A\|Cassidy, J\|Murray, G I\|McLeod, H L
PMID:	11668512

50.
Journal:	Ann Oncol. 2001 Sep;12(9):1301-6.
Title:	Relationship between 5-fluorouracil disposition, toxicity and dihydropyrimidine dehydrogenase activity in cancer patients.
Author:	Di Paolo, A\|Danesi, R\|Falcone, A\|Cionini, L\|Vannozzi, F\|Masi, G\|Allegrini, G\|Mini, E\|Bocci, G\|Conte, P F\|Del Tacca, M
PMID:	11697844

51.
Journal:	Gan To Kagaku Ryoho. 2001 Oct;28(11):1624-7.
Title:	[Effect of peroral doxifluridine plus hepatic arterial infusion for synchronous liver metastasis of colorectal cancer--correlation with the expression of thymidine phosphorylase and dihydropyrimidine dehydrogenase in primary colorectal cancer lesions].
Author:	Ishida, H\|Fujioka, M\|Ohsawa, T\|Takeuchi, I\|Nakada, H\|Ishizuka, N\|Yokoyama, M\|Inokuma, S\|Yamada, H\|Odaka, A\|Hoshino, T\|Murata, N\|Hashimoto, D\|Matsumoto, Y\|Miura, T
PMID:	11707995

52.
Journal:	Gan To Kagaku Ryoho. 2001 Dec;28(13):2035-41.
Title:	[Activities of thymidylate synthase and dihydropyrimidine dehydrogenase in patients with colorectal cancer].
Author:	Uehara, M\|Takahashi, S\|Takenaka, A\|Izumi, H\|Fujii, K\|Ikawa, O\|Miyata, K\|Iizuka, R\|Matsumura, H\|Kakihara, N\|Shono, Y\|Tsuchihashi, H\|Saisaka, Y
PMID:	11791381

53.
Journal:	J Cancer Res Clin Oncol. 2002 Feb;128(2):96-102.
Title:	Circadian variation of dihydropyrimidine dehydrogenase mRNA expression in leukocytes and serum cortisol levels in patients with advanced gastrointestinal carcinomas compared to healthy controls.
Author:	Raida, M\|Kliche, K-O\|Schwabe, W\|Hausler, P\|Clement, J H\|Behnke, D\|Hoffken, K
PMID:	11862480

54.
Journal:	Gan To Kagaku Ryoho. 2002 Mar;29(3):413-20.
Title:	[Correlation between clinical pathophysiologic factors and expression of orotate phosphoribosyl transferase (OPRT), thymidylate synthase (TS), and dihydropyrimidine dehydrogenase (DPD) in colorectal cancer].
Author:	Ochiai, Takumi\|Sugitani, Michiharu\|Nishimura, Kazuhiko\|Noguchi, Hajime\|Watanabe, Tomoo\|Sengoku, Hironobu\|Komiyama, Hiromitsu\|Okano, Masao
PMID:	11915731

55.
Journal:	Br J Cancer. 2002 Apr 8;86(7):1028-33.
Title:	Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene.
Author:	Maring, J G\|van Kuilenburg, A B P\|Haasjes, J\|Piersma, H\|Groen, H J M\|Uges, D R A\|Van Gennip, A H\|De Vries, E G E
PMID:	11953843

56.
Journal:	Oncol Rep. 2002 May-Jun;9(3):479-82.
Title:	Thymidine phosphorylase and dihydropyrimidine dehydrogenase levels in primary colorectal cancer show a relationship to clinical effects of 5'-deoxy-5-fluorouridine as adjuvant chemotherapy.
Author:	Nishimura, Genichi\|Terada, Itsurou\|Kobayashi, Takashi\|Ninomiya, Itasu\|Kitagawa, Hirohisa\|Fushida, Sachio\|Fujimura, Takashi\|Kayahara, Masato\|Shimizu, Koichi\|Ohta, Tetsuo\|Miwa, Koichi
PMID:	11956613

57.
Journal:	Chronobiol Int. 2002 Jan;19(1):177-89.
Title:	Clinical pharmacokinetics of 5-fluorouracil with consideration of chronopharmacokinetics.
Author:	Milano, Gerard\|Chamorey, Anne-Laure
PMID:	11962674

58.
Journal:	Gan To Kagaku Ryoho. 2002 Apr;29(4):625-8.
Title:	[A case of liver metastasis of rectal cancer demonstrating complete response to 5-FU + Leucovorin + UFT].
Author:	Ishida, Hideyuki\|Ohsawa, Tomonori\|Takeuchi, Ikuya\|Nakada, Hiroshi\|Inokuma, Shigehisa\|Hoshino, Takanobu\|Daijo, Hashimoto
PMID:	11977552

59.
Journal:	J Gastrointest Surg. 2002 May-Jun;6(3):331-7.
Title:	Association of time to recurrence with thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression in stage II and III colorectal cancer.
Author:	Kornmann, Marko\|Link, Karl H\|Galuba, Inga\|Ott, Kati\|Schwabe, Wolfgang\|Hausler, Peter\|Scholz, Peter\|Strater, Jorn\|Polat, Sucan\|Leibl, Bernhard\|Kettner, Erika\|Schlichting, Christoph\|Baumann, Wolfram\|Schramm, Harald\|Hecker, Ute\|Ridwelski, Karsten\|Vogt, Jurge
PMID:	12022983

60.
Journal:	Biochim Biophys Acta. 2002 Jul 18;1587(2-3):164-73.
Title:	Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase.
Author:	Banerjee, Debabrata\|Mayer-Kuckuk, Philipp\|Capiaux, Gina\|Budak-Alpdogan, Tulin\|Gorlick, Richard\|Bertino, Joseph R
PMID:	12084458

61.
Journal:	Gan To Kagaku Ryoho. 2002 Jun;29(6):889-93.
Title:	[Dihydropyrimidine dehydrogenase and thymidylate synthase in colon carcinoma].
Author:	Hamaji, Masayasu\|Nishida, Toshiroh\|Miyazaki, Satoru\|Nishida, Yukihiro
PMID:	12090040

62.
Journal:	Ann Surg Oncol. 2002 Jul;9(6):599-603.
Title:	Intratumoral dihydropyrimidine dehydrogenase messenger RNA level reflects tumor progression in human colorectal cancer.
Author:	Shirota, Yoshinori\|Ichikawa, Wataru\|Uetake, Hiroyuki\|Yamada, Hiroyuki\|Nihei, Zenro\|Sugihara, Kenichi
PMID:	12095978

63.
Journal:	Ther Drug Monit. 2002 Oct;24(5):588-93.
Title:	Relationship between plasma concentrations of 5-fluorouracil and 5-fluoro-5,6-dihydrouracil and toxicity of 5-fluorouracil infusions in cancer patients.
Author:	Di Paolo, Antonello\|Ibrahim, Toni\|Danesi, Romano\|Maltoni, Marco\|Vannozzi, Francesca\|Flamini, Emanuela\|Zoli, Wainer\|Amadori, Dino\|Del Tacca, Mario
PMID:	12352929

64.
Journal:	Cancer Lett. 2002 Dec 15;188(1-2):231-6.
Title:	Gender differences in the dihydropyrimidine dehydrogenase expression of colorectal cancers.
Author:	Yamashita, Kazuki\|Mikami, Yoshiko\|Ikeda, Masaharu\|Yamamura, Masahiko\|Kubozoe, Tadahiko\|Urakami, Atsushi\|Yoshida, Kazuhiro\|Kimoto, Masatoshi\|Tsunoda, Tsukasa
PMID:	12406569

65.
Journal:	Langenbecks Arch Surg. 2002 Oct;387(5-6):240-5.
Title:	Thymidine phosphorylase and dihydropyrimidine dehydrogenase activity in colorectal carcinoma and patients prognosis.
Author:	Ikeguchi, Masahide\|Makino, Masato\|Kaibara, Nobuaki
PMID:	12410361

66.
Journal:	Invest New Drugs. 2002 Nov;20(4):419-24.
Title:	Biochemical modulation of 5-fluorouacil through dihydropyrimidine dehydrogenase inhibition: a Southwest Oncology Group phase II trial of eniluracil and 5-fluorouracil in advanced resistant colorectal cancer.
Author:	Leichman, Cynthia G\|Chansky, Kari\|Macdonald, John S\|Doukas, Michael A\|Budd, G Thomas\|Giguere, Jeffrey K\|Abbruzzese, James L
PMID:	12448660

67.
Journal:	Int J Clin Oncol. 2002 Dec;7(6):335-42.
Title:	Predicting 5-FU sensitivity using human colorectal cancer specimens: comparison of tumor dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activities with in vitro chemosensitivity to 5-FU.
Author:	Isshi, Kimio\|Sakuyama, Toshikazu\|Gen, Tomoyasu\|Nakamura, Yasuyuki\|Kuroda, Toru\|Katuyama, Toshiyuki\|Maekawa, Yoshimi
PMID:	12494248

68.
Journal:	Oncol Rep. 2003 Jan-Feb;10(1):109-13.
Title:	Differential effects of two fluorouracil administration regimens for colorectal cancer.
Author:	Matsusaka, Satoshi\|Yamasaki, Hajime\|Kitayama, Yoshihiro\|Okada, Toshihiro\|Maeda, Shigeto
PMID:	12469154

69.
Journal:	Clin Cancer Res. 2003 Feb;9(2):786-91.
Title:	Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer.
Author:	Ichikawa, Wataru\|Uetake, Hiroyuki\|Shirota, Yoshinori\|Yamada, Hiroyuki\|Nishi, Naoto\|Nihei, Zenro\|Sugihara, Kenichi\|Hirayama, Renzo
PMID:	12576451

70.
Journal:	Clin Cancer Res. 2003 Feb;9(2):792-801.
Title:	Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed.
Author:	Farrugia, David C\|Ford, Hugo E R\|Cunningham, David\|Danenberg, Kathleen D\|Danenberg, Peter V\|Brabender, Jan\|McVicar, A David\|Aherne, G Wynne\|Hardcastle, Anthea\|McCarthy, Keith\|Jackman, Ann L
PMID:	12576452

71.
Journal:	Cancer Chemother Pharmacol. 2003 Feb;51(2):155-60.
Title:	Correlation between clinicopathologic factors and kinetics of metabolic enzymes for 5-fluorouracil given to patients with colon carcinoma by two different dosage regimens.
Author:	Katsumata, Kenji\|Tomioka, Hidenori\|Sumi, Tetsuo\|Yamashita, Shinya\|Takagi, Makoto\|Kato, Fumiaki\|Nakamura, Ryuji\|Koyanagi, Yasuhisa\|Aoki, Tatsuya\|Kato, Kohichiro
PMID:	12647017

72.
Journal:	Int J Clin Oncol. 2003 Apr;8(2):72-8.
Title:	Relationships between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, and orotate phosphoribosyltransferase and cell proliferative activity and 5-fluorouracil sensitivity in colorectal carcinoma.
Author:	Fujii, Ryuta\|Seshimo, Akiyoshi\|Kameoka, Shingo
PMID:	12720098

73.
Journal:	Gan To Kagaku Ryoho. 2003 Apr;30(4):495-500.
Title:	[Thymidine phosphorylase is correlated with DPD in colon cancer].
Author:	Hamaji, Masayasu\|Nishida, Toshiroh\|Miyazaki, Satoru\|Nishida, Yukihiro
PMID:	12722680

74.
Journal:	Oncol Rep. 2003 Jul-Aug;10(4):867-9.
Title:	The stability of dihydropyrimidine dehydrogenase activity in colorectal cancer tissue after resection.
Author:	Sadahiro, Sotaro\|Suzuki, Toshiyuki\|Ishikawa, Kenji\|Nakamura, Tomoki\|Kamijo, Akemi\|Saguchi, Takeshi\|Yasuda, Seiei\|Tajima, Tomoo\|Makuuchi, Hiroyasu\|Murayama, Chieko
PMID:	12792736

75.
Journal:	Anticancer Res. 2003 Mar-Apr;23(2C):1763-8.
Title:	Prognostic effects of dihydropyrimidine dehydrogenase in advanced colorectal cancer after surgery: immunohistochemistry using a new monoclonal antibody.
Author:	Tokunaga, Yukihiko\|Nakagami, Mikio\|Tokuka, Atsuo\|Ohsumi, Kiyoshi
PMID:	12820455

76.
Journal:	Cancer Sci. 2003 Jul;94(7):633-8.
Title:	Gene expression in colorectal cancer and in vitro chemosensitivity to 5-fluorouracil: a study of 88 surgical specimens.
Author:	Yoshinare, Kentaro\|Kubota, Tetsuro\|Watanabe, Masahiko\|Wada, Norihito\|Nishibori, Hideki\|Hasegawa, Hirotoshi\|Kitajima, Masaki\|Takechi, Teiji\|Fukushima, Masakazu
PMID:	12841874

77.
Journal:	Hepatogastroenterology. 2003 Jul-Aug;50(52):906-11.
Title:	The usefulness of immunohistochemical evaluation of dihydropyrimidine dehydrogenase for rectal cancer treated with preoperative radiotherapy.
Author:	Komuro, Yasuhiro\|Watanabe, Toshiaki\|Tsuno, Nelson\|Kitayama, Joji\|Inagaki, Naohito\|Nishida, Miwa\|Nagawa, Hirokazu
PMID:	12845947

78.
Journal:	Int J Cancer. 2003 Sep 20;106(5):799-805.
Title:	Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889.
Author:	Endo, Mika\|Miwa, Masanori\|Eda, Hiroyuki\|Ura, Masako\|Tanimura, Hiromi\|Ishikawa, Tohru\|Miyazaki-Nose, Taeko\|Hattori, Kazuo\|Shimma, Nobuo\|Yamada-Okabe, Hisafumi\|Ishitsuka, Hideo
PMID:	12866042

79.
Journal:	J Int Med Res. 2003 May-Jun;31(3):181-7.
Title:	Intratumoural thymidylate synthase and dihydropyrimidine dehydrogenase activities are good predictors of 5-fluorouracil sensitivity in colorectal cancer.
Author:	Ishibiki, Y\|Kitajima, M\|Sakamoto, K\|Tomiki, Y\|Sakamoto, S\|Kamano, T
PMID:	12870370

80.
Journal:	Oncol Rep. 2003 Sep-Oct;10(5):1425-9.
Title:	Intratumoral induction of thymidylate synthase mRNA by 5-FU in colorectal cancer patients: association with survival.
Author:	Tanaka-Nozaki, Motoko\|Tajiri, Takashi\|Tanaka, Noritake\|Furukawa, Kiyonori\|Takasaki, Hideaki\|Yoshimura, Kazuyasu\|Suzuki, Hideyuki\|Naito, Zenya\|Sugizaki, Yuuichi\|Merk, Hans F\|Blomeke, Brunhilde\|Kato, Shunji
PMID:	12883718

81.
Journal:	Cancer Chemother Pharmacol. 2003 Nov;52(5):399-404.
Title:	Dihydropyrimidine dehydrogenase (DPD) rapidly regenerates after inactivation by eniluracil (GW776C85) in primary and metastatic colorectal cancer.
Author:	Heslin, Martin J\|Yan, Jieming\|Weiss, Heidi\|Shao, Lingning\|Owens, Jill\|Lucas, V Sol\|Diasio, Robert B
PMID:	12904894

82.
Journal:	Anticancer Drugs. 2003 Aug;14(7):563-7.
Title:	Quantitation of dihydropyrimidine dehydrogenase (DPD) mRNA expression levels in normal colon and colorectal cancer tumor paraffin-embedded tissue specimens.
Author:	Liu, Jackie Yao\|Zhou, Weidong\|Sferruzza, Anthony D\|Bender, Richard A
PMID:	12960741

83.
Journal:	Clin Cancer Res. 2003 Sep 15;9(11):4116-24.
Title:	Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil.
Author:	Kornmann, Marko\|Schwabe, Wolfgang\|Sander, Silvia\|Kron, Martina\|Strater, Jorn\|Polat, Sucan\|Kettner, Erika\|Weiser, Hans F\|Baumann, Wolfram\|Schramm, Harald\|Hausler, Peter\|Ott, Kati\|Behnke, Detlev\|Staib, Ludger\|Beger, Hans G\|Link, Karl H
PMID:	14519634

84.
Journal:	Anticancer Drugs. 2003 Oct;14(9):695-702.
Title:	Dihydropyrimidine dehydrogenase inhibition as a strategy for the oral administration of 5-fluorouracil: utility in the treatment of advanced colorectal cancer.
Author:	Schmoll, Hans-Joachim
PMID:	14551502

85.
Journal:	Br J Cancer. 2003 Oct 20;89(8):1486-92.
Title:	Both gene expression for orotate phosphoribosyltransferase and its ratio to dihydropyrimidine dehydrogenase influence outcome following fluoropyrimidine-based chemotherapy for metastatic colorectal cancer.
Author:	Ichikawa, W\|Uetake, H\|Shirota, Y\|Yamada, H\|Takahashi, T\|Nihei, Z\|Sugihara, K\|Sasaki, Y\|Hirayama, R
PMID:	14562021

86.
Journal:	Nihon Rinsho. 2003 Sep;61 Suppl 7:233-6.
Title:	[Immunohistologic evaluation of TS, DPD, and p53 protein expression in patients with colorectal cancer having liver and pulmonary metastases].
Author:	Ishida, Hideki\|Sadahiro, Sotaro\|Tajima, Tomoo\|Makuuchi, Hiroyasu
PMID:	14574888

87.
Journal:	Br J Cancer. 2003 Nov 17;89(10):1995-2003.
Title:	Study of in vitro and in vivo effects of 1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl]diamantane (DPD), a novel cytostatic and differentiation inducing agent, on human colon cancer cells.
Author:	Wang, J J\|Chang, Y F\|Chern, Y T\|Chi, C W
PMID:	14612915

88.
Journal:	Int J Mol Med. 2003 Dec;12(6):839-44.
Title:	Population study of expression of thymidylate synthase and dihydropyrimidine dehydrogenase in patients with solid tumors.
Author:	Fukushima, Masakazu\|Morita, Masao\|Ikeda, Kazumasa\|Nagayama, Sekio
PMID:	14612954

89.
Journal:	Cancer Lett. 2004 Feb 10;204(1):97-104.
Title:	Tumor dihydropyrimidine dehydrogenase in stage II and III colorectal cancer: low level expression is a beneficial marker in oral-adjuvant chemotherapy, but is also a predictor for poor prognosis in patients treated with curative surgery alone.
Author:	Tsuji, Takashi\|Sawai, Terumitsu\|Takeshita, Hiroaki\|Nakagoe, Tohru\|Hidaka, Shigekazu\|Atsushi Nanashima\|Yamaguchi, Hiroyuki\|Yasutake, Toru\|Nagayasu, Takeshi\|Tagawa, Yutaka
PMID:	14744539

90.
Journal:	Dig Dis Sci. 2004 Jan;49(1):60-4.
Title:	Differences in dihydropyrimidine dehydrogenase activities between gastric and colorectal cancer.
Author:	Nakata, Bunzo\|Muguruma, Kazuya\|Yamagata, Shigehito\|Yukimoto, Kiyotaka\|Maeda, Kiyoshi\|Nishiguchi, Yukio\|Ohira, Masaichi\|Kato, Yasuyuki\|Hirakawa, Kosei
PMID:	14992436

91.
Journal:	Anticancer Res. 2004 Jan-Feb;24(1):273-9.
Title:	Immunohistochemical dihydropyrimidine dehydrogenase expression is a good prognostic indicator for patients with Dukes' C colorectal cancer.
Author:	Oi, Kentaro\|Makino, Masato\|Ozaki, Mai\|Takemoto, Hiroki\|Yamane, Nariyuki\|Nakamura, Seiichi\|Ikeguchi, Masahide\|Kaibara, Nobuaki
PMID:	15015608

92.
Journal:	Genet Med. 2004 Mar-Apr;6(2):102-7.
Title:	Mutations in exon 14 of dihydropyrimidine dehydrogenase and 5-Fluorouracil toxicity in Portuguese colorectal cancer patients.
Author:	Salgueiro, Natalia\|Veiga, Isabel\|Fragoso, Maria\|Sousa, Olga\|Costa, Nuno\|Pellon, Maria L\|Sanches, Evaristo\|dos Santos, Jose Guimaraes\|Teixeira, Manuel R\|Castedo, Sergio
PMID:	15017333

93.
Journal:	Clin Colorectal Cancer. 2004 Feb;3(4):225-34.
Title:	Dihydropyrimidine dehydrogenase and thymidylate synthase polymorphisms and their association with 5-fluorouracil/leucovorin chemotherapy in colorectal cancer.
Author:	Zhu, Andrew X\|Puchalski, Thomas A\|Stanton, Vincent P Jr\|Ryan, David P\|Clark, Jeffrey W\|Nesbitt, Steven\|Charlat, Olga\|Kelly, Patrick\|Kreconus, Elaine\|Chabner, Bruce A\|Supko, Jeffrey G
PMID:	15025795

94.
Journal:	Cancer Chemother Pharmacol. 2004 May;53(5):391-6.
Title:	Gene expression of 5-fluorouracil metabolic enzymes in primary colorectal cancer and corresponding liver metastasis.
Author:	Inokuchi, Mikito\|Uetake, Hiroyuki\|Shirota, Yoshinori\|Yamada, Hiroyuki\|Tajima, Masayuki\|Sugihara, Kenichi
PMID:	15060742

95.
Journal:	Oncol Rep. 2004 May;11(5):1045-51.
Title:	Comparative analysis of thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in gastric and colorectal cancers.
Author:	Hotta, Tsukasa\|Taniguchi, Katsutoshi\|Kobayashi, Yasuhito\|Johata, Kiyofumi\|Sahara, Masaki\|Naka, Teiji\|Watanabe, Takashi\|Ochiai, Minoru\|Tanimura, Hiroshi\|Tsubota, Yukari T
PMID:	15069545

96.
Journal:	Oncol Rep. 2004 Jun;11(6):1233-9.
Title:	Preoperative endoscopic analysis of thymidine phosphorylase and dihydropyrimidine dehydrogenase in gastrointestinal cancer.
Author:	Hotta, Tsukasa\|Taniguchi, Katsutoshi\|Kobayashi, Yasuhito\|Johata, Kiyofumi\|Sahara, Masaki\|Naka, Teiji\|Watanabe, Takashi\|Ochiai, Minoru\|Tanimura, Hiroshi\|Tsubota, Yukari T
PMID:	15138561

97.
Journal:	Gan To Kagaku Ryoho. 2004 Jun;31(6):883-7.
Title:	[Tumoral dihydropyrimidine dehydrogenase expression and efficacy of 5-fluorouracil plus leucovorin plus UFT therapy in patients with colorectal cancer].
Author:	Ishida, Hideyuki\|Ohsawa, Tomonori\|Nakada, Hiroshi\|Yokoyama, Masaru\|Inokuma, Shigehisa\|Shirakawa, Kazuo\|Yamada, Hirofumi\|Hashimoto, Daijo
PMID:	15222105

98.
Journal:	Gan To Kagaku Ryoho. 2004 Jun;31(6):889-92.
Title:	[Thymidylate synthase and dihydropyrimidine dehydrogenase gene expressions in colorectal cancer using the Danenberg tumor profile method].
Author:	Nagano, Hiroto\|Ichikawa, Wataru\|Simizu, Michio\|Shirota, Yoshinori\|Nihei, Zenro
PMID:	15222106

99.
Journal:	Gan To Kagaku Ryoho. 2004 Jul;31(7):1053-6.
Title:	[Choice of chemotherapeutic drugs for colorectal cancers by DPD and OPRT activities in cancer tissues].
Author:	Takemura, Masashi\|Osugi, Harushi\|Lee, Shigeru\|Kaneko, Masahiro\|Tanaka, Yoshinori\|Fujiwara, Yushi\|Nishizawa, Satoshi\|Iwasaki, Hiroshi
PMID:	15272584

100.
Journal:	Cancer Chemother Pharmacol. 2004 Dec;54(6):531-6.
Title:	Tumor dihydropyrimidine dehydrogenase expression is a useful marker in adjuvant therapy with oral fluoropyrimidines after curative resection of colorectal cancer.
Author:	Tsuji, Takashi\|Sawai, Terumitsu\|Takeshita, Hiroaki\|Nakagoe, Tohru\|Hidaka, Shigekazu\|Yamaguchi, Hiroyuki\|Yasutake, Toru\|Nagayasu, Takeshi\|Tagawa, Yutaka
PMID:	15309506

101.
Journal:	Crit Rev Oncol Hematol. 2004 Oct;52(1):73-80.
Title:	The role of uracil-tegafur (UFT) in elderly patients with colorectal cancer.
Author:	Labianca, Roberto\|Beretta, Giordano D\|Mosconi, Stefania\|Milesi, Laura
PMID:	15363468

102.
Journal:	Gan To Kagaku Ryoho. 2004 Sep;31(9):1357-60.
Title:	[Prognosis and efficacy of postoperative adjuvant chemotherapy in colorectal cancer correlates with nucleic acid metabolizing enzymes].
Author:	Katsumata, Kenji\|Sumi, Tetsuo\|Wada, Tatehiko\|Katou, Koichiro\|Aoki, Tatsuya
PMID:	15446556

103.
Journal:	J Pathol. 2004 Dec;204(5):562-8.
Title:	Thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase expression, and histological tumour regression after 5-FU-based neo-adjuvant chemoradiotherapy in rectal cancer.
Author:	Jakob, Christiane\|Aust, Daniela E\|Meyer, Wolfdietrich\|Baretton, Gustavo B\|Schwabe, Wolfgang\|Hausler, Peter\|Becker, Heinz\|Liersch, Torsten
PMID:	15538739

104.
Journal:	Ai Zheng. 2004 Nov;23(11 Suppl):1512-6.
Title:	[Relationship between dihydropyrimidine dehydrogenase(DPD) activity and toxicity of 5-FU-based adjuvant chemotherapy in colorectal cancer patients].
Author:	Zhou, Zhi-Wei\|Wang, Guo-Qiang\|Wan, De-Sen\|Pan, Zhi-Zhong\|Li, Su\|Chen, Gong\|Liao, Hai
PMID:	15566669

105.
Journal:	J Chemother. 2004 Nov;16 Suppl 4:25-30.
Title:	Prospective clinical trials using a pharmacogenetic/pharmacogenomic approach.
Author:	Peters, G J\|Smorenburg, C H\|Van Groeningen, C J
PMID:	15688605

106.
Journal:	Toxicol Appl Pharmacol. 2005 Jan 1;202(1):1-12.
Title:	Effects of 1, 6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl]diamantane (DPD), a reactive oxygen species and apoptosis inducing agent, on human leukemia cells in vitro and in vivo.
Author:	Chang, Y F\|Chi, C W\|Chern, Y T\|Wang, J J
PMID:	15589971

107.
Journal:	Br J Cancer. 2005 Jan 31;92(2):259-64.
Title:	Unfavourable expression of pharmacologic markers in mucinous colorectal cancer.
Author:	Glasgow, S C\|Yu, J\|Carvalho, L P\|Shannon, W D\|Fleshman, J W\|McLeod, H L
PMID:	15655543

108.
Journal:	Gan To Kagaku Ryoho. 2005 Feb;32(2):183-7.
Title:	[Assessment of dihydropyrimidine dehydrogenase and thymidylate synthase expression in gastric carcinoma and colonic carcinoma].
Author:	Yoshida, Toru\|Shimooki, Osamu\|Baba, Yuko\|Abe, Tadashi\|Sugai, Tamotsu\|Nakamura, Shin-ichi
PMID:	15751630

109.
Journal:	J Gastroenterol. 2005 Feb;40(2):143-7.
Title:	Expression level of thymidylate synthase is a good predictor of chemosensitivity to 5-fluorouracil in colorectal cancer.
Author:	Inoue, Tamotsu\|Hibi, Kenji\|Nakayama, Goro\|Komatsu, Yoshinao\|Fukuoka, Tomoki\|Kodera, Yasuhiro\|Ito, Katsuki\|Akiyama, Seiji\|Nakao, Akimasa
PMID:	15770397

110.
Journal:	Clin Cancer Res. 2005 Apr 1;11(7):2612-9.
Title:	Variance in the expression of 5-Fluorouracil pathway genes in colorectal cancer.
Author:	Kidd, Elizabeth A\|Yu, Jinsheng\|Li, Xia\|Shannon, William D\|Watson, Mark A\|McLeod, Howard L
PMID:	15814641

111.
Journal:	Ai Zheng. 2005 Apr;24(4):483-7.
Title:	[Relationship of serum level of dihydropyrimidine dehydrogenase and serum concentration of 5-fluorouracil to treatment response and adverse events in colorectal cancer patients].
Author:	Dong, Qiu-Mei\|He, You-Jian\|Li, Su\|Zhou, Zhong-Mei\|Zhang, Li\|Zhou, Zhi-Wei\|Xia, Zhong-Jun\|Li, Yu-Yan
PMID:	15820075

112.
Journal:	Cancer Lett. 2005 May 10;222(1):107-12.
Title:	Changes over time in thymidine phosphorylase and dihydropyrimidine dehydrogenase when colon cancer samples are left at room temperature.
Author:	Ishida, Hideyuki\|Tatsuta, Masayuki\|Yamamoto, Hirofumi\|Furukawa, Hiroshi\|Masutani, Seizou\|Takemoto, Hiroyoshi\|Munakata, Satoru\|Miwa, Hideaki\|Sekimoto, Mitsugu\|Monden, Morito
PMID:	15837547

113.
Journal:	Anticancer Res. 2005 Mar-Apr;25(2B):1237-42.
Title:	Expression of dihydropyrimidine dehydrogenase, thymidylate synthase, p53 and p21 in metastatic liver tumor from colorectal cancer after 5-fluorouracil-based chemotherapy.
Author:	Yamagishi, Shigeru\|Shimada, Hiroshi\|Ishikawa, Takashi\|Fujii, Shouichi\|Tanaka, Kuniya\|Masui, Hidenobu\|Yamaguchi, Shigeki\|Ichikawa, Yasushi\|Togo, Shinji\|Ike, Hideyuki
PMID:	15865071

114.
Journal:	Neoplasma. 2005;52(3):208-10.
Title:	Comparative analysis of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in colorectal cancer and surrounding normal tissue.
Author:	Zimovjanova, M\|Sykora, V\|Novotny, J\|Gatek, J\|Petruzelka, L\|Holubec, L\|Pecen, L
PMID:	15875081

115.
Journal:	Methods Mol Med. 2005;111:257-65.
Title:	Real-time RT-PCR (TaqMan) of tumor mRNA to predict sensitivity of specimens to 5-fluorouracil.
Author:	Kubota, Tetsuro
PMID:	15911984

116.
Journal:	Beijing Da Xue Xue Bao. 2005 Jun 18;37(3):269-72.
Title:	[Expression of metabolic enzymes of fluoropyrimidines in primary colorectal cancer and its clinical significance].
Author:	Wang, Hua\|Dong, Pei-de\|Zhang, Lian-hai\|Ji, Jia-fu
PMID:	15968317

117.
Journal:	Ann Oncol. 2005 Oct;16(10):1646-53.
Title:	Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients.
Author:	Westra, J L\|Hollema, H\|Schaapveld, M\|Platteel, I\|Oien, K A\|Keith, W N\|Mauritz, R\|Peters, G J\|Buys, C H C M\|Hofstra, R M W\|Plukker, J Th M
PMID:	16012177

118.
Journal:	Oncol Rep. 2005 Aug;14(2):331-5.
Title:	The activities of thymidine phosphorylase and dihydropyrimidine dehydrogenase in colorectal cancer depend on where the sample is taken.
Author:	Ogawa, Masaichi\|Ikeuchi, Kenji\|Takao, Yoshihiko\|Kobayashi, Tetsuya\|Eto, Ken\|Ushigome, Takurou\|Watanabe, Michiaki\|Anazawa, Sadao\|Yamazaki, Yoji\|Yanaga, Katsuhiko
PMID:	16012711

119.
Journal:	Chronobiol Int. 2005;22(4):741-54.
Title:	Circadian rhythm in dihydropyrimidine dehydrogenase activity and reduced glutathione content in peripheral blood of nasopharyngeal carcinoma patients.
Author:	Zeng, Zhao-Lei\|Sun, Jian\|Guo, Ling\|Li, Su\|Wu, Ming-wei\|Qiu, Fang\|Jiang, Wen-qi\|Levi, Francis\|Xian, Li-jian
PMID:	16147904

120.
Journal:	Am J Surg Pathol. 2005 Oct;29(10):1304-9.
Title:	Immunohistochemical analysis of thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer (cUICC II/III): correlation with histopathologic tumor regression after 5-fluorouracil-based long-term neoadjuvant chemorad
Author:	Jakob, Christiane\|Liersch, Torsten\|Meyer, Wolfdietrich\|Baretton, Gustavo B\|Hausler, Peter\|Schwabe, Wolfgang\|Becker, Heinz\|Aust, Daniela E
PMID:	16160472

121.
Journal:	Gan To Kagaku Ryoho. 2005 Nov;32(12):1929-34.
Title:	[Expression of mRNA levels of thymidylate synthase, dihydropyrimidine dehydrogenase, and orotate phosphoribosyltransferase of colorectal cancer--relationships among mRNA levels in association with response to 5-FU based treatment].
Author:	Ishida, Hideyuki\|Shirakawa, Kazuo\|Ohsawa, Tomonori\|Sobajima, Jun\|Hayashi, Yoichi\|Nakada, Hiroshi\|Yokoyama, Masaru\|Hashimoto, Daijo
PMID:	16282729

122.
Journal:	Anticancer Res. 2005 Nov-Dec;25(6A):3755-61.
Title:	Expression levels of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) in patients with gastrointestinal cancer.
Author:	Nakayama, Yoshifumi\|Inoue, Yuzuru\|Nagashima, Nobuo\|Katsuki, Takefumi\|Matsumoto, Kentarou\|Kadowaki, Koji\|Shibao, Kazunori\|Tsurudome, Yosuke\|Hirata, Keiji\|Sako, Tatsuhiko\|Nagata, Naoki\|Itoh, Hideaki
PMID:	16302736

123.
Journal:	Zhonghua Yi Xue Za Zhi. 2005 Aug 10;85(30):2136-9.
Title:	[Expression of dihydropyrimidine dehydrogenase in human colorectal carcinoma and its clinical implications].
Author:	Xiao, Ju-xiang\|Han, Mei\|Li, Li\|Zhu, Juan\|Chen, Li-hong\|Bai, Pei-song
PMID:	16313827

124.
Journal:	Gan To Kagaku Ryoho. 2005 Oct;32(11):1679-81.
Title:	[Clinicopathological significance of pyrimidine nucleoside phosphorylase (PyNPase) and dihydropyrimidine dehydrogenase (DPD) in advanced colorectal cancer].
Author:	Otsuka, Shinya\|Tanabe, Shunsuke\|Tsunemitsu, Yousuke\|Ariki, Norifumi\|Miyoshi, Kazuya\|Inagaki, Masaru\|Takahashi, Masahiko\|Oosaki, Toshihide\|Fuchimoto, Sadanori\|Yumura, Masahito
PMID:	16315907

125.
Journal:	Hepatogastroenterology. 2005 Nov-Dec;52(66):1715-21.
Title:	Clinical role of thymidine phosphorylase and dihydropyrimidine dehydrogenase in colorectal cancer treated with postoperative fluoropyrimidine.
Author:	Tokunaga, Yukihiko\|Takahashi, Keichi\|Saito, Tohru
PMID:	16334763

126.
Journal:	Nagoya J Med Sci. 2005 Jun;67(3-4):117-24.
Title:	Polymorphism of dihydropyrimidine dehydrogenase (DPYD) Cys29Arg and risk of six malignancies in Japanese.
Author:	Tanaka, Daisuke\|Hishida, Asahi\|Matsuo, Keitaro\|Iwata, Hiroji\|Shinoda, Masayuki\|Yamamura, Yoshitaka\|Kato, Tomoyuki\|Hatooka, Shunzo\|Mitsudomi, Tetsuya\|Kagami, Yoshitoyo\|Ogura, Michinori\|Tajima, Kazuo\|Suyama, Motokazu\|Naito, Mariko\|Yamamoto, Kazuhito\|Tamakos
PMID:	17375478

127.
Journal:	Int J Colorectal Dis. 2006 Apr;21(3):238-47. Epub 2005 Aug 13.
Title:	Thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expression in primary colorectal tumors-correlation to tumor histopathology and clinical follow-up.
Author:	Lassmann, Silke\|Hennig, Michael\|Rosenberg, Robert\|Nahrig, Jorg\|Schreglmann, Joachim\|Krause, Friedemann\|Poignee-Heger, Manuela\|Nekarda, Hjalmar\|Hofler, Heinz\|Werner, Martin
PMID:	16132996

128.
Journal:	Ann Oncol. 2006 Jan;17(1):35-42. Epub 2005 Oct 26.
Title:	Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase.
Author:	Smorenburg, C H\|Peters, G J\|van Groeningen, C J\|Noordhuis, P\|Smid, K\|van Riel, A M G H\|Dercksen, W\|Pinedo, H M\|Giaccone, G
PMID:	16251201

129.
Journal:	J Surg Oncol. 2006 Jan 1;93(1):47-55.
Title:	Upregulation of thymidine phosphorylase in rectal cancer tissues by mitomycin C.
Author:	Ogata, Yutaka\|Matono, Keiko\|Sasatomi, Teruo\|Ishibashi, Nobuya\|Torigoe, Shojiro\|Fukumitsu, Takamasa\|Mizobe, Tomoaki\|Yamashita, Natsumi\|Yanagawa, Takashi\|Shirouzu, Kazuo
PMID:	16353181

130.
Journal:	Cancer Chemother Pharmacol. 2006 May;57(5):693-702.
Title:	Antitumor activity of erlotinib in combination with capecitabine in human tumor xenograft models.
Author:	Ouchi, Kaori F\|Yanagisawa, Mieko\|Sekiguchi, Fumiko\|Tanaka, Yutaka
PMID:	16362295

131.
Journal:	Cancer Lett. 2006 Oct 28;242(2):168-79.
Title:	Tumor quantification of several fluoropyrimidines resistance gene expression with a unique quantitative RT-PCR method. Implications for pretherapeutic determination of tumor resistance phenotype.
Author:	Barbado, Maud\|Preisser, Laurence\|Boisdron-Celle, Michele\|Verriele, Veronique\|Lorimier, Gerard\|Gamelin, Erick\|Morel, Alain
PMID:	16387426

132.
Journal:	Int J Oncol. 2006 Feb;28(2):527-33.
Title:	Molecular factors of 5-fluorouracil metabolism in colorectal cancer: analysis of primary tumor and lymph node metastasis.
Author:	Vallbohmer, D\|Kuramochi, H\|Shimizu, D\|Danenberg, K D\|Lindebjerg, J\|Nielsen, J N\|Jakobsen, A\|Danenberg, P V
PMID:	16391809

133.
Journal:	Int J Cancer. 2006 Jun 15;118(12):3084-8.
Title:	Prognostic impact of orotate phosphoribosyl transferase among 5-fluorouracil metabolic enzymes in resectable colorectal cancers treated by oral 5-fluorouracil-based adjuvant chemotherapy.
Author:	Ochiai, Takumi\|Nishimura, Kazuhiko\|Noguchi, Hajime\|Kitajima, Masayuki\|Tsukada, Akira\|Watanabe, Emiko\|Nagaoka, Isao\|Futagawa, Shunji
PMID:	16425285

134.
Journal:	Int J Cancer. 2006 Jul 15;119(2):406-13.
Title:	Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: three-gene expression model predicts clinical response.
Author:	Matsuyama, Ryusei\|Togo, Shinji\|Shimizu, Daisuke\|Momiyama, Nobuyoshi\|Ishikawa, Takashi\|Ichikawa, Yasushi\|Endo, Itaru\|Kunisaki, Chikara\|Suzuki, Harukazu\|Hayasizaki, Yoshihide\|Shimada, Hiroshi
PMID:	16477629

135.
Journal:	Oncol Rep. 2006 Apr;15(4):875-82.
Title:	Correlation between chemosensitivity and mRNA expression level of 5-fluorouracil-related metabolic enzymes during liver metastasis of colorectal cancer.
Author:	Okumura, Kenji\|Shiomi, Hisanori\|Mekata, Eiji\|Kaizuka, Machiko\|Endo, Yoshihiro\|Kurumi, Yoshimasa\|Tani, Tohru
PMID:	16525674

136.
Journal:	Surg Today. 2006;36(4):348-53.
Title:	Thymidine phosphorylase and dihydropyrimidine dehydrogenase expression levels in tumor and normal tissue specimens of T3 human colorectal carcinoma.
Author:	Okita, Atsushi\|Tsukuda, Kazunori\|Murakami, Masakazu\|Ota, Tetsuya\|Doihara, Hiroyoshi\|Suda, Manabu\|Nakano, Tomoharu\|Matsuoka, Kinya\|Suzuki, Eiji\|Naito, Minoru\|Andou, Akio\|Shimizu, Nobuyoshi
PMID:	16554992

137.
Journal:	J Gastroenterol. 2006 Feb;41(2):140-50.
Title:	Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines.
Author:	Miyazaki, Kaori\|Shibahara, Takeshi\|Sato, Daisuke\|Uchida, Kazuhiko\|Suzuki, Hideo\|Matsui, Hirofumi\|Yanaka, Akinori\|Nakahara, Akira\|Matsuzaki, Yasushi
PMID:	16568373

138.
Journal:	Int J Cancer. 2006 Aug 1;119(3):522-6.
Title:	5-fluorouracil-related gene expression levels in primary colorectal cancer and corresponding liver metastasis.
Author:	Kuramochi, Hidekazu\|Hayashi, Kazuhiko\|Uchida, Kazumi\|Miyakura, Satoru\|Shimizu, Daisuke\|Vallbohmer, Daniel\|Park, Seongjin\|Danenberg, Kathleen D\|Takasaki, Ken\|Danenberg, Peter V
PMID:	16572420

139.
Journal:	Anticancer Res. 2006 Mar-Apr;26(2B):1391-6.
Title:	Thymidylate synthase and dihydropyrimidine dehydrogenase expressions in gallbladder cancer.
Author:	Ajiki, Tetsuo\|Hirata, Kenro\|Okazaki, Taro\|Horiuchi, Hideki\|Fujita, Tsunenori\|Habara, Kazuto\|Kamigaki, Takashi\|Suzuki, Yasuyuki\|Kuroda, Yoshikazu
PMID:	16619549

140.
Journal:	Am J Health Syst Pharm. 2006 May 1;63(9 Suppl 2):S12-7.
Title:	Individualizing chemotherapeutic treatment of colorectal cancer.
Author:	Crews, Kristine R
PMID:	16641252

141.
Journal:	J Exp Clin Cancer Res. 2006 Mar;25(1):79-82.
Title:	Plasma level of a 5-fluorouracil metabolite, fluoro-beta-alanine correlates with dihydropyrimidine dehydrogenase activity of peripheral blood mononuclear cells in 5-fluorouracil treated patients.
Author:	Furuhata, T\|Kawakami, M\|Okita, K\|Kimura, Y\|Kihara, C\|Tsuruma, T\|Ohmura, T\|Yamaguchi, K\|Hata, F\|Katsuramaki, T\|Sasaki, K\|Hirata, K
PMID:	16761622

142.
Journal:	Gan To Kagaku Ryoho. 2006 Jun;33(6):789-93.
Title:	[Correlation between clinical pathologic factors and enzymatic activity of orotate Phosphoribosyl transferase (OPRT), Dihydropyrimidine dehydrogenase (DPD) and Thymidylate synthase (TS) in colorectal cancer].
Author:	Yamada, Takeshi\|Tanaka, Nobutaka\|Yokoi, Kimiyoshi\|Ishikawa, Noriyuki\|Seya, Tomoko\|Kanazawa, Yoshikazu\|Shirakawa, Takashi\|Ohkawa, Keiichi\|Koizumi, Michihiro\|Ohaki, Yoshiharu\|Yamashita, Kiyohiko\|Tajiri, Takashi
PMID:	16770098

143.
Journal:	Oncol Rep. 2006 Jul;16(1):177-82.
Title:	The relationship between survival and the expression of dihydropyrimidine dehydrogenase in patients with colorectal cancer.
Author:	Hotta, Tsukasa\|Takifuji, Katsunari\|Taniguchi, Katsutoshi\|Sahara, Masaki\|Yokoyama, Shozo\|Matsuda, Kenji\|Higashiguchi, Takashi\|Tominaga, Toshiji\|Oku, Yoshimasa\|Yamaue, Hiroki
PMID:	16786143

144.
Journal:	J Int Med Res. 2006 May-Jun;34(3):307-15.
Title:	Methylenetetrahydrofolate reductase C677T is not associated with expression of pyrimidine metabolic enzyme genes in colorectal cancer.
Author:	Takeda, R\|Kamano, T\|Sakamoto, K\|Sugano, M\|Hosoda, S\|Watanabe, T\|Maeda, T\|Kojima, Y
PMID:	16866026

145.
Journal:	Am J Surg Pathol. 2006 Sep;30(9):1169-74.
Title:	Prognostic value of histologic tumor regression, thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer UICC Stage II/III after neoadjuvant chemoradiotherapy.
Author:	Jakob, Christiane\|Liersch, Torsten\|Meyer, Wolfdietrich\|Baretton, Gustavo B\|Schwabe, Wolfgang\|Hausler, Peter\|Kulle, Bettina\|Becker, Heinz\|Aust, Daniela E
PMID:	16931962

146.
Journal:	J Clin Oncol. 2006 Sep 1;24(25):4062-8.
Title:	Lymph node status and TS gene expression are prognostic markers in stage II/III rectal cancer after neoadjuvant fluorouracil-based chemoradiotherapy.
Author:	Liersch, Torsten\|Langer, Claus\|Ghadimi, B Michael\|Kulle, Bettina\|Aust, Daniela E\|Baretton, Gustavo B\|Schwabe, Wolfgang\|Hausler, Peter\|Becker, Heinz\|Jakob, Christiane
PMID:	16943523

147.
Journal:	Clin Cancer Res. 2006 Sep 15;12(18):5491-5.
Title:	Increased prevalence of dihydropyrimidine dehydrogenase deficiency in African-Americans compared with Caucasians.
Author:	Mattison, Lori Kay\|Fourie, Jeanne\|Desmond, Renee A\|Modak, Anil\|Saif, Muhammad Wasif\|Diasio, Robert B
PMID:	17000684

148.
Journal:	Clin Colorectal Cancer. 2006 Sep;6(3):219-23.
Title:	Hand-foot syndrome variant in a dihydropyrimidine dehydrogenase-deficient patient treated with capecitabine.
Author:	Saif, Muhammad Wasif\|Elfiky, Aymen\|Diasio, Robert
PMID:	17026792

149.
Journal:	Pharmacogenet Genomics. 2006 Nov;16(11):809-16.
Title:	Thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer and normal mucosa in patients.
Author:	Amatori, Federica\|Di Paolo, Antonello\|Del Tacca, Mario\|Fontanini, Gabriella\|Vannozzi, Francesca\|Boldrini, Laura\|Bocci, Guido\|Lastella, Marianna\|Danesi, Romano
PMID:	17047489

150.
Journal:	Oncol Rep. 2006 Dec;16(6):1165-72.
Title:	The expression profiles of orotate phosphoribosyltransferase and dihydropyrimidine dehydrogenase in gastric cancer and their clinical significance.
Author:	Oeda, Mamoru\|Yoshida, Kazuhiro\|Sanada, Yuichi\|Wada, Yoshiyuki\|Suzuki, Takahisa\|Mizuiri, Hirozumi\|Konishi, Kazuo\|Shigematsu, Hideo\|Tanabe, Kazuaki\|Fukushima, Masakazu
PMID:	17089033

151.
Journal:	Gan To Kagaku Ryoho. 2006 Nov;33(11):1603-9.
Title:	[Prediction of sensitivity to 5-fluorouracil (5-fu) by metabolic and target enzyme activities in colon cancer].
Author:	Yamada, Takeshi\|Tanaka, Noritake\|Yokoi, Kimiyoshi\|Ishikawa, Noriyuki\|Seya, Tomoko\|Horiba, Kouji\|Kanazawa, Yoshikazu\|Shirakawa, Takashi\|Ohkawa, Keiichi\|Kudoh, Hidenori\|Koizumi, Michihiro\|Yoshioka, Masato\|Shinji, Seiichi\|Yamashita, Kiyohiko\|Tajiri, Takashi
PMID:	17108726

152.
Journal:	Adv Exp Med Biol. 2006;587:211-31.
Title:	Pharmacogenomics and colorectal cancer.
Author:	Lenz, Heinz-Josef
PMID:	17163168

153.
Journal:	Oncology. 2006;70(5):366-77.
Title:	Predictive role of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer patients receiving adjuvant 5-fluorouracil.
Author:	Ciaparrone, M\|Quirino, M\|Schinzari, G\|Zannoni, G\|Corsi, D C\|Vecchio, F M\|Cassano, A\|La Torre, G\|Barone, C
PMID:	17179731

154.
Journal:	Clin Colorectal Cancer. 2006 Nov;6(4):288-96.
Title:	Profiling dihydropyrimidine dehydrogenase deficiency in patients with cancer undergoing 5-fluorouracil/capecitabine therapy.
Author:	Mercier, Cedric\|Ciccolini, Joseph
PMID:	17241513

155.
Journal:	Clin Biochem. 2007 Jan;40(1-2):11-7. Epub 2006 Sep 1.
Title:	Identification of a novel mutation in the dihydropyrimidine dehydrogenase gene in a patient with a lethal outcome following 5-fluorouracil administration and the determination of its frequency in a population of 500 patients with colorectal carcinoma.
Author:	Morel, A\|Boisdron-Celle, M\|Fey, L\|Laine-Cessac, P\|Gamelin, E
PMID:	17046731

156.
Journal:	Int J Cancer. 2007 Feb 1;120(3):694-701.
Title:	The prognostic significance of thymidylate synthase and dihydropyrimidine dehydrogenase in colorectal cancer of 303 patients adjuvantly treated with 5-fluorouracil.
Author:	Jensen, Soren Astrup\|Vainer, Ben\|Sorensen, Jens Benn
PMID:	17096352

157.
Journal:	Oncol Rep. 2007 Feb;17(2):325-8.
Title:	Polymorphisms in the thymidylate synthase and dihydropyrimidine dehydrogenase genes predict response and toxicity to capecitabine-raltitrexed in colorectal cancer.
Author:	Salgado, Josefa\|Zabalegui, Natalia\|Gil, Carmen\|Monreal, Ignacio\|Rodriguez, Javier\|Garcia-Foncillas, Jesus
PMID:	17203168

158.
Journal:	Gan To Kagaku Ryoho. 2007 Jan;34(1):113-5.
Title:	[CR of rectal cancer and synchronous liver and lung metastases obtained with TS-1 plus CPT-11 combination therapy--case report].
Author:	Katsumata, Kenji\|Mori, Yasuharu\|Hisada, Masayuki\|Ishizaki, Tetsuo\|Suzuki, Shohji\|Wada, Tatehiko\|Tsuchida, Akihiko\|Aoki, Tatsuya
PMID:	17220684

159.
Journal:	Chemotherapy. 2007;53(2):127-31.
Title:	The dihydrouracil/uracil ratios in plasma and toxicities of 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer patients.
Author:	Zhou, Zhi Wei\|Wang, Guo Qiang\|Wan, De Sen\|Lu, Zhen Hai\|Chen, Ying Bo\|Li, Su\|Chen, Gong\|Pan, Zhi Zhong
PMID:	17308379

160.
Journal:	Int J Cancer. 2007 Jun 15;120(12):2609-12.
Title:	Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression after administration of 5-fluorouracil to patients with colorectal cancer.
Author:	Mauritz, Robert\|van Groeningen, Cees J\|Smid, Kees\|Jansen, Gerrit\|Pinedo, Herbert M\|Peters, Godefridus J
PMID:	17330233

161.
Journal:	Surgery. 2007 Mar;141(3):346-53.
Title:	Clinical role of orotate phosphoribosyl transferase and dihydropyrimidine dehydrogenase in colorectal cancer treated with postoperative fluoropyrimidine.
Author:	Tokunaga, Yukihiko\|Sasaki, Hirokazu\|Saito, Tohru
PMID:	17349846

162.
Journal:	Ther Drug Monit. 2007 Apr;29(2):190-6.
Title:	Thymidylate synthase (TYMS) and dihydropyrimidine dehydrogenase (DPYD) polymorphisms in the Korean population for prediction of 5-fluorouracil-associated toxicity.
Author:	Cho, Hyun-Jung\|Park, Young Suk\|Kang, Won Ki\|Kim, Jong-Won\|Lee, Soo-Youn
PMID:	17417073

163.
Journal:	Scand J Gastroenterol. 2007 Apr;42(4):477-84.
Title:	Modified Irinotecan/5FU/Leucovorin therapy in advanced colorectal cancer and predicting therapeutic efficacy by expression of tumor-related enzymes.
Author:	Yanagisawa, Yoko\|Maruta, Fukuto\|Iinuma, Nobuyoshi\|Ishizone, Satoshi\|Koide, Naohiko\|Nakayama, Jun\|Miyagawa, Shinichi
PMID:	17454858

164.
Journal:	Anticancer Res. 2007 Mar-Apr;27(2):851-6.
Title:	Gene expression profile of 5-fluorouracil metabolic enzymes in primary colorectal cancer: potential as predictive parameters for response to fluorouracil-based chemotherapy.
Author:	Kinoshita, Mizunobu\|Kodera, Yasuhiro\|Hibi, Kenji\|Nakayama, Goro\|Inoue, Tamotsu\|Ohashi, Norifumi\|Ito, Yuichi\|Koike, Masahiko\|Fujiwara, Michitaka\|Nakao, Akimasa
PMID:	17465211

165.
Journal:	Onkologie. 2007 Jun;30(6):295-300.
Title:	Measurement of DPD and TS transcripts aimed to predict clinical benefit from fluoropyrimidines: confirmation of the trend in Russian colorectal cancer series and caution regarding the gene referees.
Author:	Iyevleva, Aglaya G\|Buslov, Konstantin G\|Togo, Alexandr V\|Matsko, Dmitry E\|Filimonenko, Vasily P\|Moiseyenko, Vladimir M\|Imyanitov, Evgeny N
PMID:	17551252

166.
Journal:	Int J Oncol. 2007 Aug;31(2):413-8.
Title:	DPD is a molecular determinant of capecitabine efficacy in colorectal cancer.
Author:	Vallbohmer, Daniel\|Yang, Dong Yun\|Kuramochi, Hidekazu\|Shimizu, D\|Danenberg, Kathleen D\|Lindebjerg, Jan\|Nielsen, Jens Nederby\|Jakobsen, Anders\|Danenberg, Peter V
PMID:	17611699

167.
Journal:	Biochem Cell Biol. 2007 Jun;85(3):337-46.
Title:	Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression.
Author:	Zhang, Xue\|Soong, Richie\|Wang, Kangsheng\|Li, Lin\|Davie, James R\|Guarcello, Vincenzo\|Diasio, Robert B
PMID:	17612628

168.
Journal:	Hepatogastroenterology. 2007 Jun;54(76):1089-93.
Title:	Pyrimidine nucleoside phosphorylase and dihydropyrimidine dihydrogenase activities as predictive factors for the efficacy of doxifluridine together with mitomycin C as adjuvant chemotherapy in primary colorectal cancer.
Author:	Nishioka, Masanori\|Miyamoto, Hidenori\|Kurita, Nobuhiro\|Higashijima, Jun\|Yoshikawa, Kouzou\|Miyatani, Tomohiko\|Shimada, Mitsuo
PMID:	17629045

169.
Journal:	Gan To Kagaku Ryoho. 2007 Jul;34(7):1073-7.
Title:	[Expression of mRNA levels of thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase and orotate phosphoribosyltransferase in diffusely infiltrating colorectal cancer].
Author:	Ishibashi, Keiichiro\|Sobajima, Jun\|Ohsawa, Tomonori\|Yokoyama, Masaru\|Miyazaki, Tatsuya\|Nakada, Hiroshi\|Gonda, Tsuyoshi\|Ishida, Hideyuki
PMID:	17637543

170.
Journal:	Magy Onkol. 2007;51(2):113-25. Epub 2007 Jul 29.
Title:	[Pharmacogenetic studies on the prediction of efficacy and toxicity of fluoropyrimidine-based adjuvant therapy in colorectal cancer].
Author:	Kralovanszky, Judit\|Adleff, Vilmos\|Hitre, Erika\|Pap, Eva\|Reti, Andrea\|Komlosi, Viktor\|Budai, Barna
PMID:	17660867

171.
Journal:	Neoplasma. 2007;54(5):447-53.
Title:	Preoperative radiotherapy and concomitant capecitabine treatment induce thymidylate synthase and thymidine phosphorylase mRNAs in rectal carcinoma.
Author:	Kocakova, I\|Svoboda, M\|Kubosova, K\|Chrenko, V\|Roubalova, E\|Krejci, E\|Sefr, R\|Slampa, P\|Frgala, T\|Zaloudik, J
PMID:	17688376

172.
Journal:	Cancer Res. 2007 Aug 15;67(16):7917-22.
Title:	Regulation of genes of the circadian clock in human colon cancer: reduced period-1 and dihydropyrimidine dehydrogenase transcription correlates in high-grade tumors.
Author:	Krugluger, Walter\|Brandstaetter, Anita\|Kallay, Eniko\|Schueller, Johann\|Krexner, Elisabeth\|Kriwanek, Stefan\|Bonner, Elisabeth\|Cross, Heide S
PMID:	17699798

173.
Journal:	Med Oncol. 2007;24(2):251-8.
Title:	*DPYD5 gene mutation contributes to the reduced DPYD enzyme activity and chemotherapeutic toxicity of 5-FU: results from genotyping study on 75 gastric carcinoma and colon carcinoma patients.**
Author:	Zhang, Hong\|Li, You-ming\|Zhang, Hao\|Jin, Xi
PMID:	17848752

174.
Journal:	Chemotherapy. 2007;53(6):442-5.
Title:	Dihydropyrimidine dehydrogenase activity during long-term adjuvant treatment with oral uracil and tegafur for colorectal cancer.
Author:	Sadahiro, Sotaro\|Suzuki, Toshiyuki\|Maeda, Yuji\|Ishikawa, Kenji\|Tanaka, Yoichi\|Yasuda, Seiei\|Kamijo, Akemi\|Makuuchi, Hiroyasu\|Murayama, Chieko
PMID:	17952005

175.
Journal:	Anticancer Res. 2007 Nov-Dec;27(6B):3899-902.
Title:	Investigation of IVS14+ 1G > A polymorphism of DPYD gene in a group of Turkish patients with colorectal cancer.
Author:	Uzunkoy, Ali\|Dilmec, Fuat\|Ozgonul, Abdullah\|van Kuilenburg, Andre B P\|Akkafa, Feridun
PMID:	18225548

176.
Journal:	Cancer Chemother Pharmacol. 2008 Apr;61(4):587-94. Epub 2007 May 23.
Title:	Expression level of thymidylate synthase mRNA reflects 5-fluorouracil sensitivity with low dose and long duration in primary colorectal cancer.
Author:	Okumura, Kenji\|Mekata, Eiji\|Shiomi, Hisanori\|Naitoh, Hiroyuki\|Abe, Hajime\|Endo, Yoshihiro\|Kurumi, Yoshimasa\|Tani, Tohru
PMID:	17520254

177.
Journal:	Clin Pharmacol Ther. 2008 Mar;83(3):413-5.
Title:	Chronopharmacokinetics of oral tegafur and uracil in colorectal cancer patients.
Author:	Etienne-Grimaldi, M-C\|Cardot, J-M\|Francois, E\|Renee, N\|Douillard, J-Y\|Gamelin, E\|Milano, G
PMID:	17637782

178.
Journal:	Pharmacogenomics J. 2008 Aug;8(4):256-67.
Title:	The influence of fluorouracil outcome parameters on tolerance and efficacy in patients with advanced colorectal cancer.
Author:	Capitain, O\|Boisdron-Celle, M\|Poirier, A-L\|Abadie-Lacourtoisie, S\|Morel, A\|Gamelin, E
PMID:	17700593

179.
Journal:	Ann Oncol. 2008 May;19(5):915-9.
Title:	Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy.
Author:	Soong, R\|Shah, N\|Salto-Tellez, M\|Tai, B C\|Soo, R A\|Han, H C\|Ng, S S\|Tan, W L\|Zeps, N\|Joseph, D\|Diasio, R B\|Iacopetta, B
PMID:	18245778

180.
Journal:	Oncol Rep. 2008 Mar;19(3):729-35.
Title:	Prognostic value of 5-fluorouracil metabolic enzyme genes in Dukes' stage B and C colorectal cancer patients treated with oral 5-fluorouracil-based adjuvant chemotherapy.
Author:	Yamada, Hideki\|Iinuma, Hisae\|Watanabe, Toshiaki
PMID:	18288408

181.
Journal:	Cancer Chemother Pharmacol. 2008 Dec;63(1):85-9.
Title:	High intratumoral dihydropyrimidine dehydrogenase mRNA levels in pancreatic cancer associated with a high rate of response to S-1.
Author:	Kuramochi, Hidekazu\|Hayashi, Kazuhiko\|Uchida, Kazumi\|Nakajima, Go\|Hatori, Takashi\|Danenberg, Kathleen D\|Danenberg, Peter V\|Yamamoto, Masakazu
PMID:	18309485

182.
Journal:	J Nippon Med Sch. 2008 Feb;75(1):23-7.
Title:	Correlation between clinical pathologic factors and activity of 5-FU-metabolizing enzymes in colorectal cancer.
Author:	Yamada, Takeshi\|Tanaka, Noritake\|Yokoi, Kimiyoshi\|Seya, Tomoko\|Kanazawa, Yoshikazu\|Koizumi, Michihiro\|Ohaki, Yoshiharu\|Tajiri, Takashi
PMID:	18360075

183.
Journal:	Anticancer Res. 2008 Jan-Feb;28(1B):389-93.
Title:	5-Fluorouracil-related gene expression in hepatic artery infusion-treated patients with hepatic metastases from colorectal carcinomas.
Author:	Sameshima, Shinichi\|Tomozawa, Shigeru\|Horikoshi, Hiroyuki\|Motegi, Kenta\|Hirayama, Isao\|Koketsu, Shinichiro\|Okada, Toshiyuki\|Kojima, Masaru\|Kon, Youichi\|Sawada, Toshio
PMID:	18383874

184.
Journal:	Pharmacol Rep. 2008 Mar-Apr;60(2):238-42.
Title:	5-Fluorouracil toxicity-attributable IVS14 + 1G > A mutation of the dihydropyrimidine dehydrogenase gene in Polish colorectal cancer patients.
Author:	Sulzyc-Bielicka, Violetta\|Binczak-Kuleta, Agnieszka\|Pioch, Wieslawa\|Kladny, Jozef\|Gziut, Katarzyna\|Bielicki, Dariusz\|Ciechanowicz, Andrzej
PMID:	18443386

185.
Journal:	Curr Drug Metab. 2008 May;9(4):336-43.
Title:	A carboxylesterase 2 gene polymorphism as predictor of capecitabine on response and time to progression.
Author:	Ribelles, N\|Lopez-Siles, J\|Sanchez, A\|Gonzalez, E\|Sanchez, M J\|Carabantes, F\|Sanchez-Rovira, P\|Marquez, A\|Duenas, R\|Sevilla, I\|Alba, E
PMID:	18473752

186.
Journal:	Dtsch Med Wochenschr. 2008 Jul;133(28-29):1501-4.
Title:	[Pharmacogenetics in oncology: 5-fluorouracil and the dihydropyrimidine dehydrogenase].
Author:	Lazar, A\|Jetter, A
PMID:	18597209

187.
Journal:	BMC Cancer. 2008 Jul 2;8:188.
Title:	Clinical implications of thymidylate synthetase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activity levels in colorectal carcinoma following radical resection and administration of adjuvant 5-FU chemotherapy.
Author:	Ishikawa, Masashi\|Miyauchi, Takayuki\|Kashiwagi, Yutaka
PMID:	18597678

188.
Journal:	Hepatogastroenterology. 2008 Mar-Apr;55(82-83):403-6.
Title:	Importance of thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase expression at the invasive front of T3 rectal cancer as prognostic factors.
Author:	Hayashi, Takenori\|Kawahara, Hidejiro\|Kobayashi, Susumu\|Kashiwagi, Hideyuki\|Hirai, Katsuya\|Yanaga, Katsuhiko
PMID:	18613375

189.
Journal:	Oncol Rep. 2008 Oct;20(4):921-7.
Title:	DNA methylotype analysis in colorectal cancer.
Author:	Yu, Jinsheng\|Freimuth, Robert R\|Culverhouse, Robert\|Marsh, Sharon\|Watson, Mark A\|McLeod, Howard L
PMID:	18813836

190.
Journal:	Int J Mol Med. 2008 Dec;22(6):709-16.
Title:	Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis.
Author:	Fukui, Yousuke\|Oka, Toshinori\|Nagayama, Sekio\|Danenberg, Peter V\|Danenberg, Kathleen D\|Fukushima, Masakazu
PMID:	19020767

191.
Journal:	Cutan Ocul Toxicol. 2008;27(4):311-5.
Title:	Atypical hand-and-foot syndrome in an African American patient treated with capecitabine with normal DPD activity: is there an ethnic disparity?
Author:	Saif, Muhammad Wasif\|Sandoval, Amanda
PMID:	19037763

192.
Journal:	PLoS One. 2008;3(12):e4003.
Title:	Strong association of a common dihydropyrimidine dehydrogenase gene polymorphism with fluoropyrimidine-related toxicity in cancer patients.
Author:	Gross, Eva\|Busse, Birgit\|Riemenschneider, Matthias\|Neubauer, Steffi\|Seck, Katharina\|Klein, Hanns-Georg\|Kiechle, Marion\|Lordick, Florian\|Meindl, Alfons
PMID:	19104657

193.
Journal:	BMC Cancer. 2008 Dec 23;8:386.
Title:	Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabine.
Author:	Uchida, Kazumi\|Danenberg, Peter V\|Danenberg, Kathleen D\|Grem, Jean L
PMID:	19105824

194.
Journal:	Pathol Biol (Paris). 2009 Sep;57(6):470-6.
Title:	The dihydrouracil/uracil ratio in plasma, clinical and genetic analysis for screening of dihydropyrimidine dehydrogenase deficiency in colorectal cancer patients treated with 5-fluorouracil.
Author:	Ben Fredj, R\|Gross, E\|Ben Ahmed, S\|Hassine, H\|Saguem, S
PMID:	18619742

195.
Journal:	J Pharm Sci. 2009 May;98(5):1885-904.
Title:	A combined pharmacokinetic-pharmacodynamic (PK-PD) model for tumor growth in the rat with UFT administration.
Author:	Sung, Jong Hwan\|Dhiman, Anjali\|Shuler, Michael L
PMID:	18803264

196.
Journal:	Int J Cancer. 2009 Mar 1;124(5):1220-6.
Title:	Molecular determinants of efficacy for 5-FU-based treatments in advanced colorectal cancer: mRNA expression for 18 chemotherapy-related genes.
Author:	Gustavsson, Bengt\|Kaiser, Christopher\|Carlsson, Goran\|Wettergren, Yvonne\|Odin, Elisabeth\|Lindskog, Elinor Bexe\|Niyikiza, Clet\|Ma, Doreen
PMID:	19051292

197.
Journal:	J Clin Pathol. 2009 Apr;62(4):364-9.
Title:	Higher expression of deoxyuridine triphosphatase (dUTPase) may predict the metastasis potential of colorectal cancer.
Author:	Kawahara, A\|Akagi, Y\|Hattori, S\|Mizobe, T\|Shirouzu, K\|Ono, M\|Yanagawa, T\|Kuwano, M\|Kage, M
PMID:	19052026

198.
Journal:	BMC Cancer. 2009 Jan 20;9:25.
Title:	Microsatellite instability in colorectal cancer and association with thymidylate synthase and dihydropyrimidine dehydrogenase expression.
Author:	Jensen, Soren A\|Vainer, Ben\|Kruhoffer, Mogens\|Sorensen, Jens B
PMID:	19154585

199.
Journal:	J Surg Oncol. 2009 Apr 1;99(5):296-301.
Title:	Dihydropyrimidine dehydrogenase mRNA expression in peripheral blood of rectal cancer patients is significantly associated with residual tumor and distant metastases following resection.
Author:	Hoffmann, Andreas-Claudius\|Brabender, Jan\|Metzger, Ralf\|Ling, Fredericke\|Warnecke-Eberz, Ute\|Lurje, Georg\|Hoelscher, Arnulf H\|Schneider, Paul M\|Vallbohmer, Daniel
PMID:	19180589

200.
Journal:	Best Pract Res Clin Gastroenterol. 2009;23(2):257-73.
Title:	Pharmacogenetics in chemotherapy of colorectal cancer.
Author:	Henriette Tanja, Lieke\|Guchelaar, Henk-Jan\|Gelderblom, Hans
PMID:	19414151

201.
Journal:	Eur J Cancer. 2009 Jul;45(11):1999-2006.
Title:	Predictive and prognostic markers for the outcome of chemotherapy in advanced colorectal cancer, a retrospective analysis of the phase III randomised CAIRO study.
Author:	Koopman, Miriam\|Venderbosch, Sabine\|van Tinteren, Harm\|Ligtenberg, Marjolijn J\|Nagtegaal, Iris\|Van Krieken, Johan H\|Punt, Cornelis J
PMID:	19457654

202.
Journal:	Neoplasma. 2009;56(4):303-16.
Title:	Influence of dihydropyrimidine dehydrogenase gene (DPYD) coding sequence variants on the development of fluoropyrimidine-related toxicity in patients with high-grade toxicity and patients with excellent tolerance of fluoropyrimidine-based chemotherapy.
Author:	Kleibl, Z\|Fidlerova, J\|Kleiblova, P\|Kormunda, S\|Bilek, M\|Bouskova, K\|Sevcik, J\|Novotny, J
PMID:	19473056

203.
Journal:	Br J Cancer. 2009 Jul 7;101(1):116-23.
Title:	High Ki67, Bax, and thymidylate synthase expression well correlates with response to chemoradiation therapy in locally advanced rectal cancers: proposal of a logistic model for prediction.
Author:	Kikuchi, M\|Mikami, T\|Sato, T\|Tokuyama, W\|Araki, K\|Watanabe, M\|Saigenji, K\|Okayasu, I
PMID:	19491899

204.
Journal:	Oncol Rep. 2009 Oct;22(4):901-6.
Title:	Microdissection is essential for gene expression analysis of irradiated rectal cancer tissues.
Author:	Inoue, Yasuhiro\|Tanaka, Koji\|Yokoe, Takeshi\|Saigusa, Susumu\|Toiyama, Yuji\|Miki, Chikao\|Kusunoki, Masato
PMID:	19724871

205.
Journal:	Clin Colorectal Cancer. 2009 Oct;8(4):231-4.
Title:	Toxicity and efficacy of 5-fluorouracil and capecitabine in a patient with TYMS gene polymorphism: A challenge or a dilemma?
Author:	Shahrokni, Armin\|Rajebi, Mohammad Reza\|Saif, Muhammad Wasif
PMID:	19822515

206.
Journal:	J Clin Oncol. 2009 Nov 20;27(33):5519-28.
Title:	Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: the FOCUS trial.
Author:	Braun, Michael S\|Richman, Susan D\|Thompson, Lindsay\|Daly, Catherine L\|Meade, Angela M\|Adlard, Julian W\|Allan, James M\|Parmar, Mahesh K B\|Quirke, Philip\|Seymour, Matthew T
PMID:	19858398

207.
Journal:	Gan To Kagaku Ryoho. 2009 Nov;36(12):2232-5.
Title:	[Expression of dihydropyrimidine dehydrogenase in primary colorectal cancer and liver metastasis--a relationship between mRNA levels in cancer cells and protein levels in cancerous tissue and effect of 5-fluorouracil].
Author:	Ishibashi, Keiichiro\|Sobajima, Jun\|Ishiguro, Toru\|Ohsawa, Tomonori\|Okada, Norimichi\|Miyazaki, Tatsuya\|Yokoyama, Masaru\|Inokuma, Shigehisa\|Ishida, Hideyuki
PMID:	20037380

208.
Journal:	Cancer Chemother Pharmacol. 2010 Jul;66(2):219-27.
Title:	Enhanced 5-fluorouracil cytotoxicity in high cyclooxygenase-2 expressing colorectal cancer cells and xenografts induced by non-steroidal anti-inflammatory drugs via downregulation of dihydropyrimidine dehydrogenase.
Author:	Reti, Andrea\|Pap, Eva\|Adleff, Vilmos\|Jeney, Andras\|Kralovanszky, Judit\|Budai, Barna
PMID:	19830428

209.
Journal:	J Surg Oncol. 2010 Oct 1;102(5):408-12.
Title:	Thymidine phosphorylase to dihydropyrimidine dehydrogenase ratio as a predictive factor of response to preoperative chemoradiation with capecitabine in patients with advanced rectal cancer.
Author:	Boskos, C S\|Liacos, C\|Korkolis, D\|Aygerinos, K\|Lamproglou, I\|Terpos, E\|Stoupa, E\|Baltatzis, G\|Beroukas, K\|Papasavvas, P\|Dimopoulos, M A\|Bamias, A
PMID:	19877119

210.
Journal:	Gastroenterol Clin Biol. 2010 Mar;34(3):218-23.
Title:	[Severe toxicity following capecitabine administration because of dihydropyrimidine deshydrogenase (DPD) deficiency].
Author:	Coursier, S\|Martelet, S\|Guillermet, A\|Emptoz, J\|Villier, C\|Bontemps, H
PMID:	20219304

211.
Journal:	Chemotherapy. 2010;56(2):120-6.
Title:	Correlations of clinicopathological factors with protein expression levels of thymidylate synthase, dihydropyrimidine dehydrogenase and orotate phosphoribosyltransferase in colorectal cancer.
Author:	Sumi, Tetsuo\|Katsumata, Kenji\|Tsuchida, Akihiko\|Ishizaki, Tetsuo\|Shimazu, Motohide\|Aoki, Tatsuya
PMID:	20407238

212.
Journal:	Cancer Sci. 2010 Aug;101(8):1853-60.
Title:	Characterization of a novel lymph node metastasis model from human colonic cancer and its preclinical use for comparison of anti-metastatic efficacy between oral S-1 and UFT/ LV.
Author:	Ito, Yuichi\|Nakanishi, Hayao\|Kodera, Yasuhiro\|Hirai, Takashi\|Nakao, Akimasa\|Kato, Tomoyuki
PMID:	20500514

213.
Journal:	Ann Pharm Fr. 2010 Jul;68(4):233-53.
Title:	[Recent developments of pharmacogenomics in the treatment of colorectal cancers].
Author:	Astier, A
PMID:	20637356

214.
Journal:	Br J Clin Pharmacol. 2010 Aug;70(2):268-72.
Title:	Absence of large intragenic rearrangements in the DPYD gene in a large cohort of colorectal cancer patients treated with 5-FU-based chemotherapy.
Author:	Pare, Laia\|Paez, David\|Salazar, Juliana\|Del Rio, Elisabeth\|Tizzano, Eduardo\|Marcuello, Eugenio\|Baiget, Montserrat
PMID:	20653680

215.
Journal:	Cancer Chemother Pharmacol. 2010 Nov;66(6):1167-71.
Title:	Value of gene polymorphisms as markers of 5-FU therapy response in stage III colon carcinoma: a pilot study.
Author:	Farina-Sarasqueta, Arantza\|van Lijnschoten, Gesina\|Rutten, Harm J T\|van den Brule, Adriaan J C
PMID:	20665215

216.
Journal:	J Int Med Res. 2010 May-Jun;38(3):870-83.
Title:	Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients.
Author:	Kristensen, M H\|Pedersen, P L\|Melsen, G V\|Ellehauge, J\|Mejer, J
PMID:	20819423

217.
Journal:	Clin Colorectal Cancer. 2010 Oct;9(4):224-8.
Title:	Routine dihydropyrimidine dehydrogenase testing for anticipating 5-fluorouracil-related severe toxicities: hype or hope?
Author:	Ciccolini, Joseph\|Gross, Eva\|Dahan, Laetitia\|Lacarelle, Bruno\|Mercier, Cedric
PMID:	20920994

218.
Journal:	J Int Med Res. 2010 Jul-Aug;38(4):1313-23.
Title:	The value of dihydrouracil/uracil plasma ratios in predicting 5-fluorouracil-related toxicity in colorectal cancer patients.
Author:	Kristensen, M H\|Pedersen, P\|Mejer, J
PMID:	20926004

219.
Journal:	Magy Onkol. 2010 Dec;54(4):377-81.
Title:	[Application of non-steroidal anti-inflammatory drugs to enhance 5-fluorouracil efficacy in experimental systems].
Author:	Reti, Andrea
PMID:	21163769

220.
Journal:	Hepatogastroenterology. 2010 Sep-Oct;57(102-103):1090-4.
Title:	Where should the specimen be excised for the chemosensitivity of colorectal cancer to 5-fluorouracil?
Author:	Ushigome, Takuro\|Kawahara, Hidejiro\|Kobayashi, Tetsuya\|Kobayashi, Susumu\|Kashiwagi, Hideyuki\|Yanaga, Katsuhiko
PMID:	21410037

221.
Journal:	J Cancer Res Clin Oncol. 2011 Feb;137(2):201-10.
Title:	Thymidilate synthase expression predicts longer survival in patients with stage II colon cancer treated with 5-flurouracil independently of microsatellite instability.
Author:	Donada, Marisa\|Bonin, Serena\|Nardon, Ermanno\|De Pellegrin, Alessandro\|Decorti, Giuliana\|Stanta, Giorgio
PMID:	20387074

222.
Journal:	Cancer Invest. 2011 Feb;29(2):130-6.
Title:	Relationship between gene expression of 5-fluorouracil metabolic enzymes and 5-fluorouracil sensitivity in primary cancer cells isolated from malignant ascites.
Author:	Wang, Tingting\|Wang, Lifeng\|Qian, Xiaoping\|Yu, Lixia\|Ding, Yitao\|Liu, Baorui
PMID:	21210725

223.
Journal:	Clin Cancer Res. 2011 Apr 1;17(7):2006-13.
Title:	A polymorphism in the cytidine deaminase promoter predicts severe capecitabine-induced hand-foot syndrome.
Author:	Caronia, Daniela\|Martin, Miguel\|Sastre, Javier\|de la Torre, Julio\|Garcia-Saenz, Jose Angel\|Alonso, Maria R\|Moreno, Leticia T\|Pita, Guillermo\|Diaz-Rubio, Eduardo\|Benitez, Javier\|Gonzalez-Neira, Anna
PMID:	21325291

224.
Journal:	Gan To Kagaku Ryoho. 2011 Jan;38(1):69-73.
Title:	[Investigation of chemotherapy based on enzyme expression and drug sensitivity test in colorectal cancer].
Author:	Tokunaga, Yukihiko\|Ohnishi, Takanori\|Sasaki, Hirokazu
PMID:	21368461

225.
Journal:	BMC Cancer. 2011 Mar 16;11:98.
Title:	Phase II study of preoperative radiation plus concurrent daily tegafur-uracil (UFT) with leucovorin for locally advanced rectal cancer.
Author:	Cellier, Patrice\|Leduc, Bernard\|Martin, Laurent\|Vie, Brigitte\|Chevelle, Christian\|Vendrely, Veronique\|Salemkour, Augustin\|Carrie, Christian\|Calais, Gilles\|Burtin, Pascal\|Campion, Loic\|Boisdron-Celle, Michele\|Morel, Alain\|Berger, Virginie\|Gamelin, Erick
PMID:	21410976

226.
Journal:	Clin Cancer Res. 2011 May 15;17(10):3455-68.
Title:	Relationship between single nucleotide polymorphisms and haplotypes in DPYD and toxicity and efficacy of capecitabine in advanced colorectal cancer.
Author:	Deenen, Maarten J\|Tol, Jolien\|Burylo, Artur M\|Doodeman, Valerie D\|de Boer, Anthonius\|Vincent, Andrew\|Guchelaar, Henk-Jan\|Smits, Paul H M\|Beijnen, Jos H\|Punt, Cornelis J A\|Schellens, Jan H M\|Cats, Annemieke
PMID:	21498394

227.
Journal:	Curr Drug Metab. 2011 Dec;12(10):918-31.
Title:	Pharmacokinetic and metabolism determinants of fluoropyrimidines and oxaliplatin activity in treatment of colorectal patients.
Author:	Gnoni, Antonio\|Russo, Antonio\|Silvestris, Nicola\|Maiello, Evaristo\|Vacca, Angelo\|Marech, Ilaria\|Numico, Gianmauro\|Paradiso, Angelo\|Lorusso, Vito\|Azzariti, Amalia
PMID:	21787270

228.
Journal:	Anticancer Res. 2011 Sep;31(9):2763-71.
Title:	Prognostic significance of thymidylate synthase expression in the adjuvant chemotherapy after resection for pulmonary metastases from colorectal cancer.
Author:	Kaira, Kyoichi\|Okumura, Takehiro\|Ohde, Yasuhisa\|Takahashi, Toshiaki\|Murakami, Haruyasu\|Kondo, Haruhiko\|Nakajima, Takashi\|Yamamoto, Nobuyuki
PMID:	21868518

229.
Journal:	Pharmacogenomics. 2011 Sep;12(9):1257-67.
Title:	The association of polymorphisms in 5-fluorouracil metabolism genes with outcome in adjuvant treatment of colorectal cancer.
Author:	Afzal, Shoaib\|Gusella, Milena\|Jensen, Soren Astrup\|Vainer, Ben\|Vogel, Ulla\|Andersen, Jon Traerup\|Brodbaek, Kasper\|Petersen, Morten\|Jimenez-Solem, Espen\|Adleff, Vilmos\|Budai, Barna\|Hitre, Erika\|Lang, Istvan\|Orosz, Eniko\|Bertolaso, Laura\|Barile, Carmen\|Padr
PMID:	21919605

230.
Journal:	Cancer Biol Ther. 2011 Oct 1;12(7):557-68. Epub 2011 Oct 1.
Title:	Preliminary observations indicate variable patterns of plasma 5-fluorouracil (5-FU) levels during dose optimization of infusional 5-FU in colorectal cancer patients.
Author:	Kline, Christina Leah\|Sheikh, Hassan S\|Scicchitano, Angelique\|Gingrich, Rebecca\|Beachler, Cheryl\|Finnberg, Niklas K\|Liao, Jason\|Sivik, Jeffrey\|El-Deiry, Wafik S
PMID:	21931273

231.
Journal:	Br J Cancer. 2011 Nov 22;105(11):1654-62.
Title:	Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer.
Author:	Thomas, F\|Motsinger-Reif, A A\|Hoskins, J M\|Dvorak, A\|Roy, S\|Alyasiri, A\|Myerson, R J\|Fleshman, J W\|Tan, B R\|McLeod, H L
PMID:	22045187

232.
Journal:	Gan To Kagaku Ryoho. 2011 Nov;38(12):2224-7.
Title:	[The Relationship between the efficacy of mFOLFOX6 treatment and the expression of TS, DPD, TP, and ERCC-1 in unresectable colorectal cancer].
Author:	Kuwabara, Kouki\|Kumamoto, Kensuke\|Ishibashi, Keiichiro\|Okada, Norimichi\|Ishiguro, Toru\|Ohsawa, Tomonori\|Haga, Norihiro\|Miura, Ichiro\|Ishida, Hideyuki
PMID:	22202337

233.
Journal:	Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):138-44.
Title:	X-ray cross-complementing group 1 and thymidylate synthase polymorphisms might predict response to chemoradiotherapy in rectal cancer patients.
Author:	Lamas, Maria J\|Duran, Goretti\|Gomez, Antonio\|Balboa, Emilia\|Anido, Urbano\|Bernardez, Beatriz\|Rana-Diez, Pablo\|Lopez, Rafael\|Carracedo, Angel\|Barros, Francisco
PMID:	21167658

234.
Journal:	Dig Liver Dis. 2012 Jan;44(1):74-9.
Title:	Phase II study of pharmacogenetic-tailored therapy in elderly colorectal cancer patients.
Author:	Scartozzi, Mario\|Loretelli, Cristian\|Berardi, Rossana\|Pierantoni, Chiara\|Silva, Rosa Rita\|Mari, Davide\|Giampieri, Riccardo\|Faloppi, Luca\|Pistelli, Mirco\|Maccaroni, Elena\|Bittoni, Alessandro\|Del Prete, Michela\|Galizia, Eva\|Cascinu, Stefano
PMID:	21893437

235.
Journal:	J Surg Oncol. 2012 May;105(6):529-34.
Title:	TS and DPD mRNA levels on formalin-fixed paraffin-embedded specimens as predictors for distant recurrence of rectal cancer treated with preoperative chemoradiotherapy.
Author:	Tanaka, Koji\|Saigusa, Susumu\|Toiyama, Yuji\|Koike, Yuki\|Okugawa, Yoshinaga\|Yokoe, Takeshi\|Inoue, Yasuhiro\|Kobayashi, Minako\|Miki, Chikao\|Kusunoki, Masato
PMID:	22006578

236.
Journal:	Cancer. 2012 Jun 1;118(11):2935-43.
Title:	Pretherapeutic uracil and dihydrouracil levels of colorectal cancer patients are associated with sex and toxic side effects during adjuvant 5-fluorouracil-based chemotherapy.
Author:	Wettergren, Yvonne\|Carlsson, Goran\|Odin, Elisabeth\|Gustavsson, Bengt
PMID:	22020693

237.
Journal:	Int J Clin Exp Med. 2012;5(2):186-94. Epub 2012 Apr 6.
Title:	ERCC1 C118T associates with response to FOLFOX4 chemotherapy in colorectal cancer patients in Han Chinese.
Author:	Chai, Haina\|Pan, Jie\|Zhang, Xuelin\|Zhang, Xiaoyan\|Shen, Xiaoying\|Li, Hang\|Zhang, Kehao\|Yang, Changqing\|Sheng, Haihui\|Gao, Hengjun
PMID:	22567180

238.
Journal:	Anticancer Res. 2012 May;32(5):1757-62.
Title:	Expression levels of thymidylate synthase, dihydropyrimidine dehydrogenase, and thymidine phosphorylase in patients with colorectal cancer.
Author:	Goto, Tetsuhiro\|Shinmura, Kazuki\|Yokomizo, Kazuaki\|Sakuraba, Kazuma\|Kitamura, Youhei\|Shirahata, Atsushi\|Saito, Mitsuo\|Kigawa, Gaku\|Nemoto, Hiroshi\|Sanada, Yutaka\|Hibi, Kenji
PMID:	22593457

239.
Journal:	Cancer Chemother Pharmacol. 2012 Jul;70(1):25-32.
Title:	Phase II and gene expression analysis trial of neoadjuvant capecitabine plus irinotecan followed by capecitabine-based chemoradiotherapy for locally advanced rectal cancer: Hoosier Oncology Group GI03-53.
Author:	Chiorean, E Gabriela\|Sanghani, Sonal\|Schiel, Marissa A\|Yu, Menggang\|Burns, Matthew\|Tong, Yan\|Hinkle, David T\|Coleman, Nicki\|Robb, Bruce\|LeBlanc, Julia\|Clark, Romnee\|Bufill, Jose\|Curie, Colleen\|Loehrer, Patrick J\|Cardenes, Higinia
PMID:	22610353

240.
Journal:	Anticancer Res. 2012 Jun;32(6):2277-82.
Title:	Expression of dihydropyrimidine dehydrogenase, orotate phosphoribosyl transferase and thymidylate synthase in patients with primary colorectal cancer, and associations with site of first metastasis.
Author:	Akagi, Yoshito\|Kinugasa, Tetsushi\|Mizobe, Tomoaki\|Kawahara, Akihiko\|Kage, Masayoshi\|Shirouzu, Kazuo
PMID:	22641663

241.
Journal:	Oncol Lett. 2012 May;3(5):983-989.
Title:	Thymidylate synthase and thymidine phosphorylase mRNA expression in primary lesions using laser capture microdissection is useful for prediction of the efficacy of FOLFOX treatment in colorectal cancer patients with liver metastasis.
Author:	Kumamoto, Kensuke\|Kuwabara, Koki\|Tajima, Yusuke\|Amano, Kunihiko\|Hatano, Satoshi\|Ohsawa, Tomonori\|Okada, Norimichi\|Ishibashi, Keiichiro\|Haga, Norihiro\|Ishida, Hideyuki
PMID:	22783377

242.
Journal:	Pharmacogenomics. 2012 Jul;13(10):1173-91.
Title:	Pharmacogenetic markers of toxicity for chemotherapy in colorectal cancer patients.
Author:	Cortejoso, Lucia\|Lopez-Fernandez, Luis A
PMID:	22909207

243.
Journal:	Clin Transl Oncol. 2012 Sep;14(9):641-58.
Title:	Management of colorectal cancer patients after resection of liver metastases: can we offer a tailored treatment?
Author:	Lopez-Gomez, Miriam\|Cejas, Paloma\|Merino, Maria\|Fernandez-Luengas, David\|Casado, Enrique\|Feliu, Jaime
PMID:	22911546

244.
Journal:	Curr Top Med Chem. 2012;12(15):1713-9.
Title:	Population pharmacokinetic analysis of 5-FU and 5-FDHU in colorectal cancer patients: search for biomarkers associated with gastro-intestinal toxicity.
Author:	Woloch, Christian\|Di Paolo, Antonello\|Marouani, Hafedh\|Bocci, Guido\|Ciccolini, Joseph\|Lacarelle, Bruno\|Danesi, Romano\|Iliadis, Athanassios
PMID:	22978343

245.
Journal:	Carcinogenesis. 2012 Dec;33(12):2311-9.
Title:	Splice isoforms as therapeutic targets for colorectal cancer.
Author:	Miura, Koh\|Fujibuchi, Wataru\|Unno, Michiaki
PMID:	23118106

246.
Journal:	Front Genet. 2013 Jan 17;3:312.
Title:	High-resolution melting analysis of the common c.1905+1G>A mutation causing dihydropyrimidine dehydrogenase deficiency and lethal 5-fluorouracil toxicity.
Author:	Borras, Emma\|Dotor, Emma\|Arcusa, Angels\|Gamundi, Maria J\|Hernan, Imma\|de Sousa Dias, Miguel\|Mane, Begona\|Agundez, Jose A G\|Blanca, Miguel\|Carballo, Miguel
PMID:	23335937

247.
Journal:
Title:	Capecitabine Therapy and DPYD Genotype
Author:	Dean, Laura
PMID:	28520372

248.
Journal:
Title:	Fluorouracil Therapy and DPYD Genotype
Author:	Dean, Laura
PMID:	28520376

249.
Journal:	Biomed Chromatogr. 2013 Jan;27(1):7-16.
Title:	LC-MS/MS method for simultaneous analysis of uracil, 5,6-dihydrouracil, 5-fluorouracil and 5-fluoro-5,6-dihydrouracil in human plasma for therapeutic drug monitoring and toxicity prediction in cancer patients.
Author:	Buchel, Barbara\|Rhyn, Peter\|Schurch, Stefan\|Buhr, Claudia\|Amstutz, Ursula\|Largiader, Carlo R
PMID:	22454320

250.
Journal:	Hepatogastroenterology. 2013 Mar-Apr;60(122):291-5.
Title:	Analysis of the mRNA expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyl transferase (OPRT) in liver metastases from colorectal cancer.
Author:	Yamane, Takao\|Seshimo, Akiyoshi\|Kameoka, Shingo
PMID:	22945388

251.
Journal:	Clin Colorectal Cancer. 2013 Mar;12(1):8-14.
Title:	Alternative treatment options in colorectal cancer patients with 5-fluorouracil- or capecitabine-induced cardiotoxicity.
Author:	Deboever, Guido\|Hiltrop, Nick\|Cool, Mike\|Lambrecht, Guy
PMID:	23102544

252.
Journal:	Eur J Drug Metab Pharmacokinet. 2013 Sep;38(3):171-81.
Title:	Pharmacokinetics of 5-fluorouracil and increased hepatic dihydropyrimidine dehydrogenase activity levels in 1,2-dimethylhydrazine-induced colorectal cancer model rats.
Author:	Kobuchi, Shinji\|Ito, Yukako\|Okada, Kae\|Imoto, Kazuki\|Takada, Kanji
PMID:	23197286

253.
Journal:	Oncol Rep. 2013 Feb;29(2):437-44.
Title:	Factors predicting the response to oral fluoropyrimidine drugs: a phase II trial on the individualization of postoperative adjuvant chemotherapy using oral fluorinated pyrimidines in stage III colorectal cancer treated by curative resection (ACT-01 Study)
Author:	Mori, Takeo\|Ohue, Masayuki\|Takii, Yasumasa\|Hashizume, Tadashi\|Kato, Tomoyuki\|Kotake, Kenjiro\|Sato, Toshihiko\|Tango, Toshiro
PMID:	23232805

254.
Journal:	Cancer Res. 2013 Mar 15;73(6):1958-68.
Title:	Phenotypic profiling of DPYD variations relevant to 5-fluorouracil sensitivity using real-time cellular analysis and in vitro measurement of enzyme activity.
Author:	Offer, Steven M\|Wegner, Natalie J\|Fossum, Croix\|Wang, Kangsheng\|Diasio, Robert B
PMID:	23328581

255.
Journal:	Clin Colorectal Cancer. 2013 Jun;12(2):122-7.
Title:	Role of conventional chemosensitivity test and tissue biomarker expression in predicting response to treatment of peritoneal carcinomatosis from colon cancer.
Author:	Arienti, Chiara\|Tesei, Anna\|Verdecchia, Giorgio Maria\|Framarini, Massimo\|Virzi, Salvatore\|Grassi, Antonio\|Scarpi, Emanuela\|Turci, Livia\|Silvestrini, Rosella\|Amadori, Dino\|Zoli, Wainer
PMID:	23332421

256.
Journal:	Biol Pharm Bull. 2013;36(6):907-16. Epub 2013 Apr 11.
Title:	Pre-therapeutic assessment of plasma dihydrouracil/uracil ratio for predicting the pharmacokinetic parameters of 5-fluorouracil and tumor growth in a rat model of colorectal cancer.
Author:	Kobuchi, Shinji\|Ito, Yukako\|Okada, Kae\|Imoto, Kazuki\|Kuwano, Shota\|Takada, Kanji
PMID:	23575271

257.
Journal:	J Oncol. 2013;2013:386906.
Title:	Analysis of the mRNA expression of chemotherapy-related genes in colorectal carcinoma using the danenberg tumor profile method.
Author:	Sasaki, Shin\|Watanabe, Toshiyuki\|Nakayama, Hiroshi
PMID:	23577026

258.
Journal:	Cancer Chemother Pharmacol. 2013 Aug;72(2):483-8.
Title:	DMET (Drug-Metabolizing Enzymes and Transporters) microarray analysis of colorectal cancer patients with severe 5-fluorouracil-induced toxicity.
Author:	Rumiato, Enrica\|Boldrin, Elisa\|Amadori, Alberto\|Saggioro, Daniela
PMID:	23760813

259.
Journal:	Int J Med Sci. 2013 May 20;10(7):894-902.
Title:	Evaluation of clinical value of single nucleotide polymorphisms of dihydropyrimidine dehydrogenase gene to predict 5-fluorouracil toxicity in 60 colorectal cancer patients in China.
Author:	Zhang, Xin\|Sun, Butong\|Lu, Zhenxia
PMID:	23781135

260.
Journal:	In Vivo. 2013 Jul-Aug;27(4):531-4.
Title:	Bolus 5-fluorouracil as an alternative in patients with cardiotoxicity associated with infusion 5-fluorouracil and capecitabine: a case series.
Author:	Saif, Muhammad Wasif\|Garcon, Marie Carmel\|Rodriguez, Gladys\|Rodriguez, Teresa
PMID:	23812226

261.
Journal:	Biopharm Drug Dispos. 2013 Oct;34(7):365-76.
Title:	A predictive biomarker for altered 5-fluorouracil pharmacokinetics following repeated administration in a rat model of colorectal cancer.
Author:	Kobuchi, Shinji\|Kuwano, Shota\|Imoto, Kazuki\|Okada, Kae\|Nishimura, Asako\|Ito, Yukako\|Shibata, Nobuhito\|Takada, Kanji
PMID:	23836081

262.
Journal:	Ther Drug Monit. 2013 Oct;35(5):624-30.
Title:	Potential of dihydropyrimidine dehydrogenase genotypes in personalizing 5-fluorouracil therapy among colorectal cancer patients.
Author:	Teh, Lay Kek\|Hamzah, Sharina\|Hashim, Hazwanie\|Bannur, Zakaria\|Zakaria, Zainul Amiruddin\|Hasbullani, Zakaria\|Shia, John Kwong Siew\|Fijeraid, Henry\|Md Nor, Azmid\|Zailani, Mohd\|Ramasamy, Prabu\|Ngow, Harris\|Sood, Suneet\|Salleh, Mohd Zaki
PMID:	23942539

263.
Journal:	Oncol Rep. 2013 Dec;30(6):2845-51.
Title:	Protein-bound polysaccharide-K augments the anticancer effect of fluoropyrimidine derivatives possibly by lowering dihydropyrimidine dehydrogenase expression in gastrointestinal cancers.
Author:	Mekata, Eiji\|Murata, Satoshi\|Sonoda, Hiromichi\|Shimizu, Tomoharu\|Umeda, Tomoko\|Shiomi, Hisanori\|Naka, Shigeyuki\|Yamamoto, Hiroshi\|Abe, Hajime\|Edamatsu, Takeo\|Fujieda, Ayako\|Fujioka, Masaki\|Wada, Tsutomu\|Tani, Tohru
PMID:	24100378

264.
Journal:	PLoS One. 2013 Oct 22;8(10):e78053.
Title:	Evaluating predictive pharmacogenetic signatures of adverse events in colorectal cancer patients treated with fluoropyrimidines.
Author:	Jennings, Barbara A\|Loke, Yoon K\|Skinner, Jane\|Keane, Melanie\|Chu, Gavin S\|Turner, Richard\|Epurescu, Daniel\|Barrett, Ann\|Willis, Gavin
PMID:	24167597

265.
Journal:	Gan To Kagaku Ryoho. 2013 Nov;40(11):1549-52.
Title:	[A case in which dihydropyrimidine dehydrogenase deficiency was strongly suspected during adjuvant chemotherapy with capecitabine for colon cancer].
Author:	Toshima, Toshiaki\|Kodera, Masahito\|Yamashita, Yutaka\|Oishi, Masahiro\|Seshimo, Ken\|Yamamura, Masao\|Kato, Hiroshi\|Ikeda, Hideaki\|Mizuno, Kenji
PMID:	24231713

266.
Journal:	Mol Clin Oncol. 2013 May;1(3):453-460.
Title:	Predictive value of orotate phosphoribosyltransferase in colorectal cancer patients receiving 5-FU-based chemotherapy.
Author:	Komori, Shuji\|Osada, Shinji\|Tomita, Hiroyuki\|Nishio, Kimitoshi\|Kumazawa, Iwao\|Tachibana, Susumu\|Tsuchiya, Juji\|Yoshida, Kazuhiro
PMID:	24649191

267.
Journal:	Biochem Biophys Res Commun. 2014 Jan 17;443(3):789-95.
Title:	Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro.
Author:	Deng, Jun\|Lei, Wan\|Fu, Jian-Chun\|Zhang, Ling\|Li, Jun-He\|Xiong, Jian-Ping
PMID:	24275137

268.
Journal:	J Clin Oncol. 2014 Apr 1;32(10):1031-9.
Title:	Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.
Author:	Rosmarin, Dan\|Palles, Claire\|Church, David\|Domingo, Enric\|Jones, Angela\|Johnstone, Elaine\|Wang, Haitao\|Love, Sharon\|Julier, Patrick\|Scudder, Claire\|Nicholson, George\|Gonzalez-Neira, Anna\|Martin, Miguel\|Sargent, Daniel\|Green, Erin\|McLeod, Howard\|Zanger, Ul
PMID:	24590654

269.
Journal:	Br J Cancer. 2014 May 27;110(11):2728-37.
Title:	Molecular patterns in deficient mismatch repair colorectal tumours: results from a French prospective multicentric biological and genetic study.
Author:	Etienne-Grimaldi, M-C\|Mahamat, A\|Chazal, M\|Laurent-Puig, P\|Olschwang, S\|Gaub, M-P\|Formento, J-L\|Formento, P\|Sudaka, A\|Boige, V\|Abderrahim-Ferkoune, A\|Benchimol, D\|Andre, T\|Houry, S\|Faucheron, J-L\|Letoublon, C\|Gilly, F-N\|Delpero, J-R\|Lasser, P\|Pradere, B\|P
PMID:	24800948

270.
Journal:	Eur Rev Med Pharmacol Sci. 2014;18(8):1247-58.
Title:	The role of IVS14+1 G > A genotype detection in the dihydropyrimidine dehydrogenase gene and pharmacokinetic monitoring of 5-fluorouracil in the individualized adjustment of 5-fluorouracil for patients with local advanced and metastatic colorectal cancer:
Author:	Cai, X\|Fang, J-M\|Xue, P\|Song, W-F\|Hu, J\|Gu, H-L\|Yang, H-Y\|Wang, L-W
PMID:	24817302

271.
Journal:	Oncol Rep. 2014 Sep;32(3):887-92.
Title:	Impact of 5-fluorouracil metabolizing enzymes on chemotherapy in patients with resectable colorectal cancer.
Author:	Ochiai, Takumi\|Umeki, Masahiko\|Miyake, Hiroshi\|Iida, Tatsumi\|Okumura, Minoru\|Ohno, Kazuhide\|Sakamoto, Masashi\|Miyoshi, Nobukazu\|Takahashi, Masahiko\|Tsumura, Hidenori\|Tokunaga, Yukihiko\|Naitou, Haruhiko\|Fukui, Takuji
PMID:	24994673

272.
Journal:	J Adv Pract Oncol. 2014 May;5(3):205-10.
Title:	Delayed Presentation of DPD Deficiency in Colorectal Cancer.
Author:	Law, Lindsey\|Rogers, Jane\|Eng, Cathy
PMID:	25089219

273.
Journal:	Cancer Chemother Pharmacol. 2014 Oct;74(4):757-63.
Title:	Pretherapeutic uracil and dihydrouracil levels in saliva of colorectal cancer patients are associated with toxicity during adjuvant 5-fluorouracil-based chemotherapy.
Author:	Carlsson, Goran\|Odin, Elisabeth\|Gustavsson, Bengt\|Wettergren, Yvonne
PMID:	25102934

274.
Journal:	Farm Hosp. 2014 Jul 1;38(4):283-90.
Title:	[Validation of genetic polymorphisms associated to the toxicity of chemotherapy in colorectal cancer patients].
Author:	Cortejoso, L\|Garcia, M I\|Garcia-Alfonso, P\|Gravalos, C\|Robles, L\|Gonzalez-Haba, E\|Sanjurjo, M\|Lopez-Fernandez, L A
PMID:	25137161

275.
Journal:	Anticancer Res. 2014 Sep;34(9):4949-62.
Title:	Prognostic markers in early-stage colorectal cancer: significance of TYMS mRNA expression.
Author:	Koumarianou, Anna\|Tzeveleki, Ioanna\|Mekras, Dimosthenis\|Eleftheraki, Anastasia G\|Bobos, Mattheos\|Wirtz, Ralph\|Fountzilas, Elena\|Valavanis, Christos\|Xanthakis, Ioannis\|Kalogeras, Konstantine T\|Basdanis, George\|Pentheroudakis, George\|Kotoula, Vassiliki\|Foun
PMID:	25202077

276.
Journal:	J Natl Cancer Inst. 2014 Nov 7;106(12). pii: dju298.
Title:	DPYD variants as predictors of 5-fluorouracil toxicity in adjuvant colon cancer treatment (NCCTG N0147).
Author:	Lee, Adam M\|Shi, Qian\|Pavey, Emily\|Alberts, Steven R\|Sargent, Daniel J\|Sinicrope, Frank A\|Berenberg, Jeffrey L\|Goldberg, Richard M\|Diasio, Robert B
PMID:	25381393

277.
Journal:	BMC Cancer. 2014 Nov 24;14:875.
Title:	Phase 1/2 study of valproic acid and short-course radiotherapy plus capecitabine as preoperative treatment in low-moderate risk rectal cancer-V-shoRT-R3 (Valproic acid--short Radiotherapy--rectum 3rd trial).
Author:	Avallone, Antonio\|Piccirillo, Maria Carmela\|Delrio, Paolo\|Pecori, Biagio\|Di Gennaro, Elena\|Aloj, Luigi\|Tatangelo, Fabiana\|D'Angelo, Valentina\|Granata, Cinzia\|Cavalcanti, Ernesta\|Maurea, Nicola\|Maiolino, Piera\|Bianco, Franco\|Montano, Massimo\|Silvestro, Luc
PMID:	25421252

278.
Journal:	Gastroenterol Res Pract. 2014;2014:827989.
Title:	Influence of DPYD Genetic Polymorphisms on 5-Fluorouracil Toxicities in Patients with Colorectal Cancer: A Meta-Analysis.
Author:	Li, Qiang\|Liu, Ying\|Zhang, Hong-Mei\|Huang, Yin-Peng\|Wang, Tian-Yi\|Li, Dong-Sheng\|Sun, Hong-Zhi
PMID:	25614737

279.
Journal:	Int J Clin Exp Med. 2014 Dec 15;7(12):5857-61. eCollection 2014.
Title:	Correlation analysis of peripheral DPYD gene polymorphism with 5-fluorouracil susceptibility and side effects in colon cancer patients.
Author:	Sun, Wenhui\|Yan, Chungen\|Jia, Shaochang\|Hu, Jianhua
PMID:	25664120

280.
Journal:	Am J Ther. 2015 Mar-Apr;22(2):e36-9.
Title:	Dihydropyrimidine dehydrogenase 85T>C mutation is associated with ocular toxicity of 5-fluorouracil: a case report.
Author:	Baskin, Yasemin\|Amirfallah, Arsalan\|Unal, Olcun Umit\|Calibasi, Gizem\|Oztop, Ilhan
PMID:	24434920

281.
Journal:	Gut. 2015 Jan;64(1):111-20.
Title:	A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS.
Author:	Rosmarin, Dan\|Palles, Claire\|Pagnamenta, Alistair\|Kaur, Kulvinder\|Pita, Guillermo\|Martin, Miguel\|Domingo, Enric\|Jones, Angela\|Howarth, Kimberley\|Freeman-Mills, Luke\|Johnstone, Elaine\|Wang, Haitao\|Love, Sharon\|Scudder, Claire\|Julier, Patrick\|Fernandez-Roza
PMID:	24647007

282.
Journal:	Clin Transl Oncol. 2015 Apr;17(4):322-9.
Title:	Gene expression differences in primary colorectal tumors and matched liver metastases: chemotherapy related or tumoral heterogeneity?
Author:	Lopez-Gomez, M\|Moreno-Rubio, J\|Suarez-Garcia, I\|Cejas, P\|Madero, R\|Casado, E\|Jimenez, A M\|Sereno, M\|Gomez-Raposo, C\|Zambrana, F\|Merino, M\|Fernandez-Luengas, D\|Feliu, J
PMID:	25301403

283.
Journal:	Pharmacogenomics J. 2015 Jun;15(3):211-8.
Title:	Frequent intragenic rearrangements of DPYD in colorectal tumours.
Author:	van Kuilenburg, A B P\|Etienne-Grimaldi, M-C\|Mahamat, A\|Meijer, J\|Laurent-Puig, P\|Olschwang, S\|Gaub, M-P\|Hennekam, R C M\|Benchimol, D\|Houry, S\|Letoublon, C\|Gilly, F-N\|Pezet, D\|Andre, T\|Faucheron, J-L\|Abderrahim-Ferkoune, A\|Vijzelaar, R\|Pradere, B\|Milano, G
PMID:	25348620

284.
Journal:	J Surg Res. 2015 Apr;194(2):343-50.
Title:	Prognostic value of biomarkers in metastatic colorectal cancer patients.
Author:	Kataoka, Kozo\|Kanazawa, Akiyoshi\|Nakajima, Akio\|Yamaguchi, Ayane\|Arimoto, Akira
PMID:	25456112

285.
Journal:	Cancer Chemother Pharmacol. 2015 Apr;75(4):763-72.
Title:	Germline TYMS genotype is highly predictive in patients with metastatic gastrointestinal malignancies receiving capecitabine-based chemotherapy.
Author:	Joerger, M\|Huitema, A D R\|Boot, H\|Cats, A\|Doodeman, V D\|Smits, P H M\|Vainchtein, L\|Rosing, H\|Meijerman, I\|Zueger, M\|Meulendijks, D\|Cerny, T D\|Beijnen, J H\|Schellens, J H M
PMID:	25677447

286.
Journal:	Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015 Mar;31(3):328-32.
Title:	[Establishment and biological characterization of 5-fluorouracil-resistant human colon cancer HT-29/5-FU cell line].
Author:	Qiu, Tingting\|Xiang, Xiaojun\|Lei, Wan\|Hao, Chao\|Zhang, Ling\|Feng, Miao\|Yu, Feng\|Li, Junhe\|Xiong, Jianping
PMID:	25744837

287.
Journal:	Br J Clin Pharmacol. 2015 Sep;80(3):581-8.
Title:	DPD and UGT1A1 deficiency in colorectal cancer patients receiving triplet chemotherapy with fluoropyrimidines, oxaliplatin and irinotecan.
Author:	Falvella, Felicia Stefania\|Cheli, Stefania\|Martinetti, Antonia\|Mazzali, Cristina\|Iacovelli, Roberto\|Maggi, Claudia\|Gariboldi, Manuela\|Pierotti, Marco Alessandro\|Di Bartolomeo, Maria\|Sottotetti, Elisa\|Mennitto, Roberta\|Bossi, Ilaria\|de Braud, Filippo\|Cleme
PMID:	25782327

288.
Journal:	Oncology (Williston Park). 2015 Mar;29(3):175-83.
Title:	Costs and effectiveness of genomic testing in the management of colorectal cancer.
Author:	Goldstein, Daniel A\|Shaib, Walid L\|Flowers, Christopher R
PMID:	25783977

289.
Journal:	Cancer Chemother Pharmacol. 2015 May;75(5):1095-8.
Title:	Validation of a fast and low-cost alkaline lysis method for gDNA extraction in a pharmacogenetic context.
Author:	Ramos-Diaz, Ruth\|Gutierrez-Nicolas, Fernando\|Nazco-Casariego, Gloria J\|Gonzalez-Perera, Itamar\|Perez-Perez, Jose A
PMID:	25804843

290.
Journal:	IUBMB Life. 2015 Mar;67(3):191-201.
Title:	MicroRNA-494 sensitizes colon cancer cells to fluorouracil through regulation of DPYD.
Author:	Chai, Jie\|Dong, Wei\|Xie, Chao\|Wang, Lin\|Han, Da-Li\|Wang, Shan\|Guo, Hong-Liang\|Zhang, Zong-Li
PMID:	25873402

291.
Journal:	Int J Mol Sci. 2015 Apr 21;16(4):8884-95.
Title:	Undetected toxicity risk in pharmacogenetic testing for dihydropyrimidine dehydrogenase.
Author:	Falvella, Felicia Stefania\|Caporale, Marta\|Cheli, Stefania\|Martinetti, Antonia\|Berenato, Rosa\|Maggi, Claudia\|Niger, Monica\|Ricchini, Francesca\|Bossi, Ilaria\|Di Bartolomeo, Maria\|Sottotetti, Elisa\|Bernardi, Francesca Futura\|de Braud, Filippo\|Clementi, Emil
PMID:	25906475

292.
Journal:	Cancer Chemother Pharmacol. 2015 Jul;76(1):47-52.
Title:	Influence of metastatic disease on the usefulness of uracil pharmacokinetics as a screening tool for DPD activity in colorectal cancer patients.
Author:	van Staveren, Maurice C\|Opdam, Frans\|Guchelaar, Henk-Jan\|van Kuilenburg, Andre B P\|Maring, Jan Gerard\|Gelderblom, Hans
PMID:	25957957

293.
Journal:	Nanoscale. 2015 Sep 7;7(33):14080-92.
Title:	Overcoming acquired drug resistance in colorectal cancer cells by targeted delivery of 5-FU with EGF grafted hollow mesoporous silica nanoparticles.
Author:	Chen, Lijue\|She, Xiaodong\|Wang, Tao\|He, Li\|Shigdar, Sarah\|Duan, Wei\|Kong, Lingxue
PMID:	26242620

294.
Journal:	Oncotarget. 2015 Oct 20;6(32):34004-13.
Title:	Changes in expression levels of ERCC1, DPYD, and VEGFA mRNA after first-line chemotherapy of metastatic colorectal cancer: results of a multicenter study.
Author:	Baba, Hideo\|Baba, Yoshifumi\|Uemoto, Shinji\|Yoshida, Kazuhiro\|Saiura, Akio\|Watanabe, Masayuki\|Maehara, Yoshihiko\|Oki, Eiji\|Ikeda, Yasuharu\|Matsuda, Hiroyuki\|Yamamoto, Masakazu\|Shimada, Mitsuo\|Taketomi, Akinobu\|Unno, Michiaki\|Sugihara, Kenichi\|Ogata, Yutaka
PMID:	26372896

295.
Journal:	Contemp Oncol (Pozn). 2015;19(4):261-4.
Title:	The role of Reg IV in colorectal cancer, as a potential therapeutic target.
Author:	Hu, Yiwang\|Pan, Chi\|Hu, Jiyi\|Zhang, Suzhan
PMID:	26557771

296.
Journal:	Int J Clin Exp Pathol. 2015 Oct 1;8(10):12333-45. eCollection 2015.
Title:	Correlations between expression levels of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase, and efficacy of 5-fluorouracil-based chemotherapy for advanced colorectal cancer.
Author:	Bai, Wenqi\|Wu, Yueqin\|Zhang, Ping\|Xi, Yanfeng
PMID:	26722420

297.
Journal:	J Clin Pathol. 2016 Mar;69(3):204-8.
Title:	Correlation between DPYD gene variation and KRAS wild type status in colorectal cancer.
Author:	Kleist, Britta\|Kempa, Marcel\|Meurer, Thuja\|Poetsch, Micaela
PMID:	26281864

298.
Journal:	Int J Mol Med. 2016 Feb;37(2):319-28.
Title:	Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis.
Author:	Shimamoto, Yuji\|Nukatsuka, Mamoru\|Takechi, Teiji\|Fukushima, Masakazu
PMID:	26676887

299.
Journal:	Anticancer Res. 2016 Jan;36(1):21-6.
Title:	TAS-102 an Emerging Oral Fluoropyrimidine.
Author:	Chen, Jiezhong\|Han, Mei\|Saif, Muhammad Wasif
PMID:	26722024

300.
Journal:	JAMA Oncol. 2016 Jan 21. pii: 2482915.
Title:	DPYD Genotyping to Predict Adverse Events Following Treatment With Flourouracil-Based Adjuvant Chemotherapy in Patients With Stage III Colon Cancer: A Secondary Analysis of the PETACC-8 Randomized Clinical Trial.
Author:	Boige, Valerie\|Vincent, Marc\|Alexandre, Philippe\|Tejpar, Sabine\|Landolfi, Stefania\|Le Malicot, Karine\|Greil, Richard\|Cuyle, Pieter Jan\|Yilmaz, Mette\|Faroux, Roger\|Matzdorff, Axel\|Salazar, Ramon\|Lepage, Come\|Taieb, Julien\|Laurent-Puig, Pierre
PMID:	26794347

301.
Journal:	Oncotarget. 2016 Apr 12;7(15):20612-20.
Title:	Pre-treatment evaluation of 5-fluorouracil degradation rate: association of poor and ultra-rapid metabolism with severe toxicity in a colorectal cancer patients cohort.
Author:	Mazzuca, Federica\|Borro, Marina\|Botticelli, Andrea\|Mazzotti, Eva\|Marchetti, Luca\|Gentile, Giovanna\|La Torre, Marco\|Lionetto, Luana\|Simmaco, Maurizio\|Marchetti, Paolo
PMID:	26967565

302.
Journal:	Oncol Lett. 2016 May;11(5):3551-3557.
Title:	1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane potentiates in vitro and in vivo antitumor effects of irinotecan on human colorectal cancer cells.
Author:	Yang, Po-Sheng\|Wang, Jane-Jen\|Wang, Yea-Hwey\|Jan, Woan-Ching\|Cheng, Shih-Ping\|Hsu, Yi-Chiung
PMID:	27123150

303.
Journal:	Anticancer Res. 2016 May;36(5):2433-40.
Title:	Increase in Gene Expression of TYMP, DPYD and HIF1A Are Associated with Response to Preoperative Chemoradiotherapy Including S-1 or UFT for Rectal Cancer.
Author:	Sadahiro, Sotaro\|Suzuki, Toshiyuki\|Tanaka, Akira\|Okada, Kazutake\|Saito, Gota\|Kamijo, Akemi\|Nagase, Hideki
PMID:	27127154

304.
Journal:	J Cancer Res Ther. 2016 Apr-Jun;12(2):782-6.
Title:	*DPYD2A/5A/9A and UGT1A16/28 polymorphisms in Chinese colorectal cancer patients.**
Author:	Li, Guo-Yin\|Duan, Jian-Feng\|Li, Wan-Jun\|Liu, Tao
PMID:	27461651

305.
Journal:	Oncotarget. 2016 Dec 6;7(49):81880-81887.
Title:	Determining the optimal 5-FU therapeutic dosage in the treatment of colorectal cancer patients.
Author:	Fang, Ling\|Jiang, Yi\|Yang, Yuxian\|Zheng, Yuqiong\|Zheng, Jin\|Jiang, Hong\|Zhang, Shengqi\|Lin, Lifang\|Zheng, Jieting\|Zhang, Shuyao\|Zhuang, Xiaowen
PMID:	27636992

306.
Journal:	BMC Cancer. 2016 Oct 12;16(1):795.
Title:	Molecular profile of 5-fluorouracil pathway genes in colorectal carcinoma.
Author:	Kunicka, T\|Prochazka, P\|Krus, I\|Bendova, P\|Protivova, M\|Susova, S\|Hlavac, V\|Liska, V\|Novak, P\|Schneiderova, M\|Pitule, P\|Bruha, J\|Vycital, O\|Vodicka, P\|Soucek, P
PMID:	27733154

307.
Journal:	Cureus. 2016 Sep 14;8(9):e783.
Title:	The First Case of Severe Takotsubo Cardiomyopathy Associated with 5-Fluorouracil in a Patient with Abnormalities of Both Dihydropyrimidine Dehydrogenase (DPYD) and Thymidylate Synthase (TYMS) Genes.
Author:	Saif, Muhammad W\|Smith, Melissa\|Maloney, Antonio
PMID:	27752409

308.
Journal:	J BUON. 2016 Sept-Oct;21(5):1287-1295.
Title:	Pharmacogenetics in cancer therapy - 8 years of experience at the Institute for Oncology and Radiology of Serbia.
Author:	Cavic, Milena\|Krivokuca, Ana\|Boljevic, Ivana\|Brotto, Ksenija\|Jovanovic, Katarina\|Tanic, Miljana\|Filipovic, Lana\|Zec, Manja\|Malisic, Emina\|Jankovic, Radmila\|Radulovic, Sinisa
PMID:	27837635

309.
Journal:	Anticancer Drugs. 2017 Mar;28(3):322-326.
Title:	5-Fluorouracil degradation rate could predict toxicity in stages II-III colorectal cancer patients undergoing adjuvant FOLFOX.
Author:	Onesti, Concetta E\|Botticelli, Andrea\|La Torre, Marco\|Borro, Marina\|Gentile, Giovanna\|Romiti, Adriana\|Lionetto, Luana\|Petremolo, Antonella\|Occhipinti, Mario\|Roberto, Michela\|Falcone, Rosa\|Simmaco, Maurizio\|Marchetti, Paolo\|Mazzuca, Federica
PMID:	27845948

310.
Journal:	Anticancer Drugs. 2017 Jun;28(5):551-556.
Title:	A nomogram to predict 5-fluorouracil toxicity: when pharmacogenomics meets the patient.
Author:	Botticelli, Andrea\|Onesti, Concetta E\|Strigari, Lidia\|Occhipinti, Mario\|Di Pietro, Francesca R\|Cerbelli, Bruna\|Petremolo, Antonella\|Anselmi, Elisabetta\|Macrini, Serena\|Roberto, Michela\|Falcone, Rosa\|Lionetto, Luana\|Borro, Marina\|Milano, Annalisa\|Gentile,
PMID:	28296649

311.
Journal:	Pharmacol Res. 2017 Jun;120:133-137.
Title:	Identification of new SNPs associated with severe toxicity to capecitabine.
Author:	Pellicer, Marta\|Garcia-Gonzalez, Xandra\|Garcia, Maria I\|Robles, Luis\|Gravalos, Cristina\|Garcia-Alfonso, Pilar\|Pachon, Vanessa\|Longo, Federico\|Martinez, Virginia\|Blanco, Carolina\|Iglesias, Irene\|Sanjurjo, Maria\|Lopez-Fernandez, Luis A
PMID:	28347776

312.
Journal:	Semin Oncol. 2017 Feb;44(1):13-23.
Title:	Prevention of 5-fluorouracil-induced early severe toxicity by pre-therapeutic dihydropyrimidine dehydrogenase deficiency screening: Assessment of a multiparametric approach.
Author:	Boisdron-Celle, Michele\|Capitain, Olivier\|Faroux, Roger\|Borg, Christophe\|Metges, Jean Philippe\|Galais, Marie Pierre\|Kaassis, Mehdi\|Bennouna, Jaafar\|Bouhier-Leporrier, Karine\|Francois, Eric\|Baumgaertner, Isabelle\|Guerin-Meyer, Veronique\|Cojocarasu, Oana\|Ro
PMID:	28395758

313.
Journal:	Oncology (Williston Park). 2017 Apr 15;31(4):301-12.
Title:	Molecular Testing to Optimize and Personalize Decision Making in the Management of Colorectal Cancer.
Author:	Al-Hajeili, Marwan\|Shields, Anthony F\|Hwang, Jimmy J\|Wadlow, Raymond C\|Marshall, John L
PMID:	28412781

314.
Journal:	J Pharm Biomed Anal. 2017 Aug 5;142:125-135.
Title:	Development, validation and application of a novel liquid chromatography tandem mass spectrometry assay measuring uracil, 5,6-dihydrouracil, 5-fluorouracil, 5,6-dihydro-5-fluorouracil, alpha-fluoro-beta-ureidopropionic acid and alpha-fluoro-beta-alanine i
Author:	Chavani, Ottiniel\|Jensen, Berit Packert\|Strother, R Matthew\|Florkowski, Christopher M\|George, Peter M
PMID:	28501750

315.
Journal:	Asian Pac J Cancer Prev. 2017 Jun 25;18(6):1651-1654.
Title:	Low Incidence of the DPD IVS14+1G>A Polymorphism in Jordanian Breast and Colorectal Cancer patients
Author:	Al-Khateeb, Mohammad\|Awidi, Abdalla\|Al-Hadidi, Kamal\|Battah, Abdelkader
PMID:	28670884

316.
Journal:	Br J Cancer. 2017 Oct 24;117(9):1269-1277.
Title:	Dihydropyrimidine dehydrogenase pharmacogenetics for predicting fluoropyrimidine-related toxicity in the randomised, phase III adjuvant TOSCA trial in high-risk colon cancer patients.
Author:	Ruzzo, A\|Graziano, F\|Galli, Fabio\|Galli, Francesca\|Rulli, E\|Lonardi, S\|Ronzoni, M\|Massidda, B\|Zagonel, V\|Pella, N\|Mucciarini, C\|Labianca, R\|Ionta, M T\|Bagaloni, I\|Veltri, E\|Sozzi, P\|Barni, S\|Ricci, V\|Foltran, L\|Nicolini, M\|Biondi, E\|Bramati, A\|Turci, D\|La
PMID:	29065426

317.
Journal:	Gen Physiol Biophys. 2017 Dec;36(5):557-563.
Title:	DPYD genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from Slovakia.
Author:	Matakova, Tatiana\|Halasova, Erika\|Skovierova, Henrieta\|Dzian, Anton\|Dobrota, Dusan\|Skerenova, Maria
PMID:	29372689

318.
Journal:	Gan To Kagaku Ryoho. 2017 Nov;44(12):1399-1401.
Title:	[Severe Therapy-Related Pancytopenia Caused by UFT and LV in a Patient with Ascending Colon Cancer].
Author:	Akiyama, Takahiro\|Yasutomi, Jun\|Kusashio, Kimihiko\|Matsumoto, Masanari\|Suzuki, Takeshi\|Iida, Ayako\|Imamura, Namiko\|Yoshizumi, Arihito\|Harano, Rina\|Udagawa, Ikuo\|Ohtsuka, Masayuki
PMID:	29394647

319.
Journal:	Cancer Chemother Pharmacol. 2018 Jan;81(1):119-129.
Title:	*DPYD2A and MTHFR C677T predict toxicity and efficacy, respectively, in patients on chemotherapy with 5-fluorouracil for colorectal cancer.**
Author:	Nahid, Noor Ahmed\|Apu, Mohd Nazmul Hasan\|Islam, Md Reazul\|Shabnaz, Samia\|Chowdhury, Surid Mohammad\|Ahmed, Maizbha Uddin\|Nahar, Zabun\|Islam, Md Siddiqul\|Islam, Mohammad Safiqul\|Hasnat, Abul
PMID:	29134491

320.
Journal:	JAMA Oncol. 2018 Jun 1;4(6):806-813.
Title:	Assessment of Tumor Sequencing as a Replacement for Lynch Syndrome Screening and Current Molecular Tests for Patients With Colorectal Cancer.
Author:	Hampel, Heather\|Pearlman, Rachel\|Beightol, Mallory\|Zhao, Weiqiang\|Jones, Daniel\|Frankel, Wendy L\|Goodfellow, Paul J\|Yilmaz, Ahmet\|Miller, Kristin\|Bacher, Jason\|Jacobson, Angela\|Paskett, Electra\|Shields, Peter G\|Goldberg, Richard M\|de la Chapelle, Albert\|S
PMID:	29596542

321.
Journal:	Clin Proteomics. 2018 Apr 13;15:16.
Title:	The response to neoadjuvant chemoradiotherapy with 5-fluorouracil in locally advanced rectal cancer patients: a predictive proteomic signature.
Author:	Chauvin, Anais\|Wang, Chang-Shu\|Geha, Sameh\|Garde-Granger, Perrine\|Mathieu, Alex-Ane\|Lacasse, Vincent\|Boisvert, Francois-Michel
PMID:	29681787

322.
Journal:	Int J Biol Markers. 2018 May;33(2):180-188.
Title:	Deciphering the potential value of 5-fluorouracil metabolic enzymes in predicting prognosis and treatment response of colorectal cancer patients.
Author:	Gajjar, Kinjal K\|Vora, Hemangini H\|Kobawala, Toral P\|Trivedi, Trupti I\|Ghosh, Nandita R
PMID:	29799355

323.
Journal:	Cancer Chemother Pharmacol. 2018 Aug;82(2):237-243.
Title:	The association of polymorphisms in folate-metabolizing genes with response to adjuvant chemotherapy of colorectal cancer.
Author:	Yousef, Al-Motassem\|Zawiah, Mohammed\|Al-Yacoub, Shorouq\|Kadi, Taha\|Tantawi, Dua' A\|Al-Ramadhani, Hanguin
PMID:	29845393

324.
Journal:	Acta Biochim Pol. 2018;65(2):227-234.
Title:	TYMS 2R3R polymorphism and DPYD [IVS]14+1G>A gene mutation in Mexican colorectal cancer patients.
Author:	Gallegos-Arreola, Martha Patricia\|Zuniga-Gonzalez, Guillermo Moises\|Sanchez-Lopez, Josefina Yoaly\|Cruz, Alondra Yeraldi Naranjo\|Peralta-Leal, Valeria\|Figuera, Luis Eduardo\|Puebla-Perez, Ana Maria\|Ronquillo-Carreon, Carlos Alberto\|Puebla-Mora, Ana Graciela
PMID:	29906295

325.
Journal:	Drug Resist Updat. 2018 Jul;39:18-40.
Title:	Host genetic profiling to increase drug safety in colorectal cancer from discovery to implementation.
Author:	Cecchin, Erika\|De Mattia, Elena\|Ecca, Fabrizio\|Toffoli, Giuseppe
PMID:	30075835

326.
Journal:	Front Oncol. 2018 Jul 24;8:279.
Title:	A Novel DPYD Variant Associated With Severe Toxicity of Fluoropyrimidines: Role of Pre-emptive DPYD Genotype Screening.
Author:	Tong, Chi C\|Lam, Ching W\|Lam, Ka O\|Lee, Victor H F\|Luk, Mai-Yee
PMID:	30087856

327.
Journal:	Eur J Cancer. 2018 Oct;102:31-39.
Title:	Pharmacogenetic analyses of 2183 patients with advanced colorectal cancer; potential role for common dihydropyrimidine dehydrogenase variants in toxicity to chemotherapy.
Author:	Madi, Ayman\|Fisher, David\|Maughan, Timothy S\|Colley, James P\|Meade, Angela M\|Maynard, Julie\|Humphreys, Vikki\|Wasan, Harpreet\|Adams, Richard A\|Idziaszczyk, Shelley\|Harris, Rebecca\|Kaplan, Richard S\|Cheadle, Jeremy P
PMID:	30114658

328.
Journal:	Drug Metab Pers Ther. 2018 Sep 12.
Title:	Early disease relapse in a patient with colorectal cancer who harbors genetic variants of DPYD, TYMS, MTHFR and DHFR after treatment with 5-fluorouracil-based chemotherapy.
Author:	Zawiah, Mohammed\|Yousef, Al-Motassem\|Kadi, Taha\|Yousef, Mohammed\|Majdalawi, Khalil\|Al-Yacoub, Shorouq\|Al-Hiary, Rasha\|Tantawi, Dua'a\|Mukred, Ramzi\|Ajaj, Abdel Rahman
PMID:	30207288

329.
Journal:	Dose Response. 2018 Oct 1;16(4):1559325818803042.
Title:	Cost Implications of Reactive Versus Prospective Testing for Dihydropyrimidine Dehydrogenase Deficiency in Patients With Colorectal Cancer: A Single-Institution Experience.
Author:	Murphy, Con\|Byrne, Stephen\|Ahmed, Gul\|Kenny, Andrew\|Gallagher, James\|Harvey, Harry\|O'Farrell, Eoin\|Bird, Brian
PMID:	30288154

330.
Journal:	Clin Pharmacol Ther. 2018 Oct 19.
Title:	The genotype for DPYD risk variants in colorectal cancer patients and the related toxicity management costs in clinical practice.
Author:	Toffoli, Giuseppe\|Innocenti, Federico\|Polesel, Jerry\|De Mattia, Elena\|Sartor, Franca\|Fratte, Chiara Dalle\|Ecca, Fabrizio\|Dreussi, Eva\|Palazzari, Elisa\|Guardascione, Michela\|Buonadonna, Angela\|Foltran, Luisa\|Garziera, Marica\|Bignucolo, Alessia\|Nobili, Stef
PMID:	30339275