Literatures

Primary Site >> Liver Cancer

Gene >> DNMT3B

1.
Journal:	Hepatology. 2001 Mar;33(3):561-8.
Title:	Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis.
Author:	Saito, Y\|Kanai, Y\|Sakamoto, M\|Saito, H\|Ishii, H\|Hirohashi, S
PMID:	11230735

2.
Journal:	J Biol Chem. 2002 May 3;277(18):16048-58.
Title:	Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma.
Author:	Majumder, Sarmila\|Ghoshal, Kalpana\|Datta, Jharna\|Bai, Shoumei\|Dong, Xiaocheng\|Quan, Ning\|Plass, Christoph\|Jacob, Samson T
PMID:	11844796

3.
Journal:	Hepatol Res. 2003 Jul;26(3):186-191.
Title:	Expression of DNA (5-cytosin)-methyltransferases (DNMTs) in hepatocellular carcinomas.
Author:	Nagai, Maho\|Nakamura, Akihiro\|Makino, Reiko\|Mitamura, Keiji
PMID:	12850690

4.
Journal:	Cancer Biol Ther. 2005 Apr;4(4):440-8. Epub 2005 Apr 21.
Title:	A DNA repeat, NBL2, is hypermethylated in some cancers but hypomethylated in others.
Author:	Nishiyama, Rie\|Qi, Lixin\|Tsumagari, Koji\|Weissbecker, Karen\|Dubeau, Louis\|Champagne, Martin\|Sikka, Suresh\|Nagai, Hisaki\|Ehrlich, Melanie
PMID:	15846090

5.
Journal:	Cancer Lett. 2006 Feb 28;233(2):271-8.
Title:	DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma.
Author:	Park, Hye-Jung\|Yu, Eunsil\|Shim, Yhong-Hee
PMID:	15885882

6.
Journal:	Gastroenterology. 2007 Apr;132(4):1476-94.
Title:	Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein.
Author:	Park, In Young\|Sohn, Bo Hwa\|Yu, Eunsil\|Suh, Dong Jin\|Chung, Young-Hwa\|Lee, Je-Ho\|Surzycki, Stefan J\|Lee, Young Ik
PMID:	17408664

7.
Journal:	Int J Mol Med. 2007 Jul;20(1):65-73.
Title:	DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation.
Author:	Oh, Bong-Kyeong\|Kim, Haeryoung\|Park, Hye-Jung\|Shim, Yhong-Hee\|Choi, Jinsub\|Park, Chanil\|Park, Young Nyun
PMID:	17549390

8.
Journal:	Hepatol Res. 2007 Nov;37(11):974-83.
Title:	Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas.
Author:	Kondo, Yutaka\|Shen, Lanlan\|Suzuki, Seiji\|Kurokawa, Tsuyoshi\|Masuko, Kazuo\|Tanaka, Yasuhito\|Kato, Hideaki\|Mizuno, Yoshiki\|Yokoe, Masamichi\|Sugauchi, Fuminaka\|Hirashima, Noboru\|Orito, Etsuro\|Osada, Hirotaka\|Ueda, Ryuzo\|Guo, Yi\|Chen, Xinli\|Issa, Jean-Pierre
PMID:	17584191

9.
Journal:	World J Gastroenterol. 2007 Dec 7;13(45):6082-6.
Title:	DNA methyltransferase 3B promoter polymorphism and its susceptibility to primary hepatocellular carcinoma in the Chinese Han nationality population: a case-control study.
Author:	Wu, Ying\|Lin, Ju-Sheng
PMID:	18023104

10.
Journal:	Cancer Res. 2008 Jul 1;68(13):5049-58.
Title:	Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis.
Author:	Datta, Jharna\|Kutay, Huban\|Nasser, Mohd W\|Nuovo, Gerard J\|Wang, Bo\|Majumder, Sarmila\|Liu, Chang-Gong\|Volinia, Stefano\|Croce, Carlo M\|Schmittgen, Thomas D\|Ghoshal, Kalpana\|Jacob, Samson T
PMID:	18593903

11.
Journal:	Gastroenterology Res. 2008 Dec;1(1):33-39.
Title:	Inhibition of de novo Methyltransferase 3B is a Potential Therapy for Hepatocellular Carcinoma.
Author:	Fan, Hong\|Cheng, Jian\|Zhao, Zhu Jiang
PMID:	27994704

12.
Journal:	Toxicol Sci. 2009 Jun;109(2):193-205.
Title:	Phenobarbital elicits unique, early changes in the expression of hepatic genes that affect critical pathways in tumor-prone B6C3F1 mice.
Author:	Phillips, Jennifer M\|Burgoon, Lyle D\|Goodman, Jay I
PMID:	19270015

13.
Journal:	Infect Genet Evol. 2009 Sep;9(5):877-81.
Title:	Single nucleotide polymorphism in DNMT3B promoter and its association with hepatocellular carcinoma in a Moroccan population.
Author:	Ezzikouri, Sayeh\|El Feydi, Abdellah Essaid\|Benazzouz, Mustapha\|Afifi, Rajae\|El Kihal, Latifa\|Hassar, Mohammed\|Akil, Abdellah\|Pineau, Pascal\|Benjelloun, Soumaya
PMID:	19465161

14.
Journal:	Zhonghua Yi Xue Za Zhi. 2009 Mar 3;89(8):555-8.
Title:	[Influence of DNA methyltransferase 3b on the expression of cyclin D1 gene and methylation of its promoters in human hepatocellular carcinoma cells].
Author:	Wang, Jia-Chen\|Wang, Jia-Xiang\|Liu, Huai-Ran\|Zhang, Yong-Gan
PMID:	19567080

15.
Journal:	J Biomed Biotechnol. 2010;2010:737535.
Title:	Depletion of DNMT3A suppressed cell proliferation and restored PTEN in hepatocellular carcinoma cell.
Author:	Zhao, Zhujiang\|Wu, Qingxiang\|Cheng, Jian\|Qiu, Xuemei\|Zhang, Jianqiong\|Fan, Hong
PMID:	20467490

16.
Journal:	Exp Ther Med. 2010 May;1(3):519-523.
Title:	Epigenetic activation of E-cadherin is a candidate therapeutic target in human hepatocellular carcinoma.
Author:	Qiu, Xuemei\|Qiao, Fengchang\|Su, Xianwei\|Zhao, Zhujiang\|Fan, Hong
PMID:	22993570

17.
Journal:	J Cell Biochem. 2010 Sep 1;111(1):158-67.
Title:	Transcriptional and post-transcriptional control of DNA methyltransferase 3B is regulated by phosphatidylinositol 3 kinase/Akt pathway in human hepatocellular carcinoma cell lines.
Author:	Mei, Chuanzhong\|Sun, Lidong\|Liu, Yonglei\|Yang, Yong\|Cai, Xiumei\|Liu, Mingzhu\|Yao, Wantong\|Wang, Can\|Li, Xin\|Wang, Liying\|Li, Zengxia\|Shi, Yinghong\|Qiu, Shuangjian\|Fan, Jia\|Zha, Xiliang
PMID:	20506537

18.
Journal:	Cancer Sci. 2010 Jun;101(6):1431-9.
Title:	DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL-mediated apoptosis via up-regulation of TRAIL-R2/DR5 and caspase-8.
Author:	Kurita, Satoshi\|Higuchi, Hajime\|Saito, Yoshimasa\|Nakamoto, Nobuhiro\|Takaishi, Hiromasa\|Tada, Shinichiro\|Saito, Hidetsugu\|Gores, Gregory J\|Hibi, Toshifumi
PMID:	20398055

19.
Journal:	Vet Pathol. 2011 Jul;48(4):875-84.
Title:	Gene expression and mutation assessment provide clues of genetic and epigenetic mechanisms in liver tumors of oxazepam-exposed mice.
Author:	Lahousse, S A\|Hoenerhoff, M\|Collins, J\|Ton, T-V T\|Masinde, T\|Olson, D\|Rebolloso, Y\|Koujitani, T\|Tomer, K B\|Hong, H-H L\|Bucher, J\|Sills, R C
PMID:	21147764

20.
Journal:	Virol J. 2011 Mar 14;8:118.
Title:	Induction of cyclooxygenase-2 expression by hepatitis B virus depends on demethylation-associated recruitment of transcription factors to the promoter.
Author:	Yue, Xin\|Yang, Fang\|Yang, Yongbo\|Mu, Yongxin\|Sun, Wei\|Li, Wei\|Xu, Dongping\|Wu, Jianguo\|Zhu, Ying
PMID:	21401943

21.
Journal:	Cancer Lett. 2011 Nov 1;310(1):61-8.
Title:	Hepatitis C virus Core protein stimulates cell growth by down-regulating p16 expression via DNA methylation.
Author:	Park, Sun-Hye\|Lim, Joo Song\|Lim, Su-Yeon\|Tiwari, Indira\|Jang, Kyung Lib
PMID:	21757290

22.
Journal:	Oncogenesis. 2012 Sep 3;1:e25.
Title:	Epigenetic control of metastasis-associated protein 1 gene expression by hepatitis B virus X protein during hepatocarcinogenesis.
Author:	Lee, M-H\|Na, H\|Na, T-Y\|Shin, Y-K\|Seong, J-K\|Lee, M-O
PMID:	23552838

23.
Journal:	FEBS Lett. 2013 May 2;587(9):1424-8.
Title:	Hepatitis delta virus induces specific DNA methylation processes in Huh-7 liver cancer cells.
Author:	Benegiamo, Giorgia\|Vinciguerra, Manlio\|Guarnieri, Vito\|Niro, Grazia Anna\|Andriulli, Angelo\|Pazienza, Valerio
PMID:	23523924

24.
Journal:	Hepatology. 2013 Sep;58(3):1153-65.
Title:	miR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells.
Author:	Gailhouste, Luc\|Gomez-Santos, Laura\|Hagiwara, Keitaro\|Hatada, Izuho\|Kitagawa, Noriyuki\|Kawaharada, Kazushi\|Thirion, Muriel\|Kosaka, Nobuyoshi\|Takahashi, Ryou-U\|Shibata, Tatsuhiro\|Miyajima, Atsushi\|Ochiya, Takahiro
PMID:	23532995

25.
Journal:	Virology. 2013 Jun 20;441(1):57-65.
Title:	DNA methyltransferases 1 and 3B are required for hepatitis C virus infection in cell culture.
Author:	Chen, Chao\|Pan, Dan\|Deng, A-Mei\|Huang, Fang\|Sun, Bin-Lian\|Yang, Rong-Ge
PMID:	23545144

26.
Journal:	Biomed Rep. 2013 Sep;1(5):771-775.
Title:	Promoter polymorphisms of DNA methyltransferase 3B and risk of hepatocellular carcinoma.
Author:	Lao, Yingbin\|Wu, Huazhang\|Zhao, Chengchegn\|Wu, Qunying\|Qiao, Fengchang\|Fan, Hong
PMID:	24649027

27.
Journal:	Oncol Rep. 2014 Jan;31(1):202-8.
Title:	Upregulation of DNMT1 mediated by HBx suppresses RASSF1A expression independent of DNA methylation.
Author:	Qiu, Xuemei\|Zhang, Lihua\|Lu, Sen\|Song, Yunwei\|Lao, Yingbin\|Hu, Jiaojiao\|Fan, Hong
PMID:	24247422

28.
Journal:	PLoS One. 2014 Dec 30;9(12):e116179.
Title:	Trichloroethylene-induced gene expression and DNA methylation changes in B6C3F1 mouse liver.
Author:	Jiang, Yan\|Chen, Jiahong\|Tong, Jian\|Chen, Tao
PMID:	25549359

29.
Journal:	Exp Mol Pathol. 2014 Dec;97(3):477-83.
Title:	Mallory-Denk Body (MDB) formation modulates Ufmylation expression epigenetically in alcoholic hepatitis (AH) and non-alcoholic steatohepatitis (NASH).
Author:	Liu, Hui\|Gong, Ming\|French, Barbara A\|Li, Jun\|Tillman, Brittany\|French, Samuel W
PMID:	25290169

30.
Journal:	Oncol Rep. 2014 Nov;32(5):2093-103.
Title:	DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model.
Author:	Valencia Antunez, Carlos Alberto\|Taja Chayeb, Lucia\|Rodriguez-Segura, Miguel Angel\|Lopez Alvarez, Guadalupe Soledad\|Garcia-Cuellar, Claudia M\|Villa Trevino, Saul
PMID:	25190601

31.
Journal:	Toxicology. 2014 Jan 6;315:65-9.
Title:	Fumonisin B1 induces global DNA hypomethylation in HepG2 cells - An alternative mechanism of action.
Author:	Chuturgoon, Anil\|Phulukdaree, Alisa\|Moodley, Devapregasan
PMID:	24280379

32.
Journal:	Hepatol Res. 2014 Aug;44(8):907-19.
Title:	Involvement of miRNA-29a in epigenetic regulation of transforming growth factor-beta-induced epithelial-mesenchymal transition in hepatocellular carcinoma.
Author:	Kogure, Takayuki\|Kondo, Yasuteru\|Kakazu, Eiji\|Ninomiya, Masashi\|Kimura, Osamu\|Shimosegawa, Tooru
PMID:	23789939

33.
Journal:	BMC Genomics. 2014 Jun 5;15:435.
Title:	Dynamic imbalance between cancer cell subpopulations induced by transforming growth factor beta (TGF-beta) is associated with a DNA methylome switch.
Author:	Martin, Marion\|Ancey, Pierre-Benoit\|Cros, Marie-Pierre\|Durand, Geoffroy\|Le Calvez-Kelm, Florence\|Hernandez-Vargas, Hector\|Herceg, Zdenko
PMID:	24898317

34.
Journal:	Int J Oncol. 2015 Feb;46(2):782-90.
Title:	Mechanistic and biological significance of DNA methyltransferase 1 upregulated by growth factors in human hepatocellular carcinoma.
Author:	Fang, Qin-Liang\|Yin, Yi-Rui\|Xie, Cheng-Rong\|Zhang, Sheng\|Zhao, Wen-Xiu\|Pan, Chao\|Wang, Xiao-Min\|Yin, Zhen-Yu
PMID:	25420499

35.
Journal:	Mol Biosyst. 2015 Feb;11(2):532-9.
Title:	The regulation of microRNA expression by DNA methylation in hepatocellular carcinoma.
Author:	He, Xing-Xing\|Kuang, Shu-Zhen\|Liao, Jia-Zhi\|Xu, Chuan-Rui\|Chang, Ying\|Wu, Yu-Liang\|Gong, Jing\|Tian, De-An\|Guo, An-Yuan\|Lin, Ju-Sheng
PMID:	25424171

36.
Journal:	Biochem Biophys Res Commun. 2015 Jul 10;462(4):332-8.
Title:	Novel sex-dependent differentially methylated regions are demethylated in adult male mouse livers.
Author:	Ito, Shuhei\|Hirabayashi, Keiji\|Moriishi, Kohji\|Matsui, Yasuhisa\|Moriya, Kyoji\|Koike, Kazuhiko\|Matsuura, Yoshiharu\|Shiota, Kunio\|Yagi, Shintaro
PMID:	25960295

37.
Journal:	Int J Clin Exp Med. 2015 Mar 15;8(3):4175-85. eCollection 2015.
Title:	Hepatitis B virus infection in hepatocellular carcinoma tissues upregulates expression of DNA methyltransferases.
Author:	Li, Haiping\|Yang, Fengmei\|Gao, Bo\|Yu, Zongtao\|Liu, Xiaobo\|Xie, Fei\|Zhang, Jicai
PMID:	26064328

38.
Journal:	Oncol Lett. 2015 Jun;9(6):2499-2506.
Title:	DNA methyltransferase 3b silencing affects locus-specific DNA methylation and inhibits proliferation, migration and invasion in human hepatocellular carcinoma SMMC-7721 and BEL-7402 cells.
Author:	Wang, Jia-Chen\|Wang, Zhao\|Fan, Yu-Xia\|Si, Ya-Qing\|Wang, Jia-Xiang
PMID:	26137097

39.
Journal:	Mar Drugs. 2015 Sep 24;13(10):6099-116.
Title:	Fucoidan Elevates MicroRNA-29b to Regulate DNMT3B-MTSS1 Axis and Inhibit EMT in Human Hepatocellular Carcinoma Cells.
Author:	Yan, Ming-De\|Yao, Chih-Jung\|Chow, Jyh-Ming\|Chang, Chia-Lun\|Hwang, Pai-An\|Chuang, Shuang-En\|Whang-Peng, Jacqueline\|Lai, Gi-Ming
PMID:	26404322

40.
Journal:	J Exp Clin Cancer Res. 2015 Nov 14;34:140.
Title:	Hepatitis C virus core protein modulates pRb2/p130 expression in human hepatocellular carcinoma cell lines through promoter methylation.
Author:	Mileo, Anna Maria\|Mattarocci, Stefano\|Matarrese, Paola\|Anticoli, Simona\|Abbruzzese, Claudia\|Catone, Stefania\|Sacco, Rodolfo\|Paggi, Marco G\|Ruggieri, Anna
PMID:	26576645

41.
Journal:	Tumour Biol. 2016 Aug;37(8):10487-97.
Title:	DNA methyltransferase 1, 3a, and 3b expression in hepatitis C associated human hepatocellular carcinoma and their clinicopathological association.
Author:	Siddiqui, Nadir Naveed\|Ul Haq, Ahtesham\|Siddiqui, Owais Ali\|Khan, Rizma
PMID:	26850594

42.
Journal:	Oncotarget. 2016 Aug 2;7(31):50131-50149.
Title:	Inflammatory related gene IKKalpha, IKKbeta, IKKgamma cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis.
Author:	An, Jiahui\|Wu, Mengying\|Xin, Xiaoru\|Lin, Zhuojia\|Li, Xiaonan\|Zheng, Qidi\|Gui, Xin\|Li, Tianming\|Pu, Hu\|Li, Haiyan\|Lu, Dongdong
PMID:	27367027

43.
Journal:	Sci Rep. 2016 Jun 27;6:28637.
Title:	DDX3 Represses Stemness by Epigenetically Modulating Tumor-suppressive miRNAs in Hepatocellular Carcinoma.
Author:	Li, Hao-Kang\|Mai, Ru-Tsun\|Huang, Hsien-Da\|Chou, Chih-Hung\|Chang, Yi-An\|Chang, Yao-Wen\|You, Li-Ru\|Chen, Chun-Ming\|Lee, Yan-Hwa Wu
PMID:	27344963

44.
Journal:	Oncogene. 2016 Dec 8;35(49):6281-6292.
Title:	Overexpression of maelstrom promotes bladder urothelial carcinoma cell aggressiveness by epigenetically downregulating MTSS1 through DNMT3B.
Author:	Li, X-D\|Zhang, J-X\|Jiang, L-J\|Wang, F-W\|Liu, L-L\|Liao, Y-J\|Jin, X-H\|Chen, W-H\|Chen, X\|Guo, S-J\|Zhou, F-J\|Zeng, Y-X\|Guan, X-Y\|Liu, Z-W\|Xie, D
PMID:	27181205

45.
Journal:	Asian Pac J Cancer Prev. 2016;17(S3):219-24.
Title:	Evaluation of MiR-34 Family and DNA Methyltransferases 1, 3A, 3B Gene Expression Levels in Hepatocellular Carcinoma Following Treatment with Dendrosomal Nanocurcumin.
Author:	Chamani, Fatemeh\|Sadeghizadeh, Majid\|Masoumi, Mahbobeh\|Babashah, Sadegh
PMID:	27165229

46.
Journal:	Dig Dis Sci. 2016 Apr;61(4):1130-8.
Title:	Sera DNA Methylation of CDH1, DNMT3b and ESR1 Promoters as Biomarker for the Early Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma.
Author:	Dou, Cheng-Yun\|Fan, Yu-Chen\|Cao, Chuang-Jie\|Yang, Yang\|Wang, Kai
PMID:	26660680

47.
Journal:	Tumour Biol. 2016 Jan;37(1):877-85.
Title:	Genome-wide profiling of DNA methylation reveals preferred sequences of DNMTs in hepatocellular carcinoma cells.
Author:	Fan, Hong\|Zhao, Zhujiang\|Cheng, Yuchao\|Cui, He\|Qiao, Fengchang\|Wang, Ling\|Hu, Jiaojiao\|Wu, Huzhang\|Song, Wei
PMID:	26254611

48.
Journal:	Oncol Rep. 2017 Jun;37(6):3527-3535.
Title:	MicroRNA-26a inhibits proliferation and metastasis of human hepatocellular carcinoma by regulating DNMT3B-MEG3 axis.
Author:	Li, Yarui\|Ren, Mudan\|Zhao, Yan\|Lu, Xinlan\|Wang, Mengyao\|Hu, Junbi\|Lu, Guifang\|He, Shuixiang
PMID:	28440439

49.
Journal:	Toxicol Appl Pharmacol. 2017 Aug 1;328:34-45.
Title:	HMGA2, a driver of inflammation, is associated with hypermethylation in acute liver injury.
Author:	Huang, Huimin\|Li, Haidi\|Chen, Xin\|Yang, Yang\|Li, Xiaofeng\|Li, Wanxia\|Huang, Cheng\|Meng, Xiaoming\|Zhang, Lei\|Li, Jun
PMID:	28502886

50.
Journal:	Exp Mol Pathol. 2018 Apr;104(2):125-129.
Title:	Expression of proteins upregulated in hepatocellular carcinoma in patients with alcoholic hepatitis (AH) compared to non-alcoholic steatohepatitis (NASH): An immunohistochemical analysis of candidate proteins.
Author:	Lu, Jiajie George\|Nguyen, Luan\|Samadzadeh, Sara\|Masouminia, Maryam\|Mendoza, Alejandro\|Sweeney, Owen\|Tillman, Brittany\|Afifyan, Nikoo\|Morgan, Timothy\|French, Barbara A\|French, Samuel W
PMID:	29425759

51.
Journal:	Toxicol Lett. 2018 Jun 1;289:42-53.
Title:	Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells.
Author:	Chen, Hong-Qiang\|Zhao, Ji\|Li, Yan\|He, Li-Xiong\|Huang, Yu-Jing\|Shu, Wei-Qun\|Cao, Jia\|Liu, Wen-Bin\|Liu, Jin-Yi
PMID:	29518473

52.
Journal:	J Cell Mol Med. 2018 Jun;22(6):3246-3258.
Title:	Inflammatory factor receptor Toll-like receptor 4 controls telomeres through heterochromatin protein 1 isoforms in liver cancer stem cell.
Author:	Zheng, Qidi\|Xu, Jie\|Lin, Zhuojia\|Lu, Yanan\|Xin, Xiaoru\|Li, Xiaonan\|Yang, Yuxin\|Meng, Qiuyu\|Wang, Chen\|Xiong, Wujun\|Lu, Dongdong
PMID:	29602239

53.
Journal:	J Clin Transl Hepatol. 2018 Jun 28;6(2):141-146.
Title:	Effect of Genistein in Comparison with Trichostatin A on Reactivation of DNMTs Genes in Hepatocellular Carcinoma.
Author:	Sanaei, Masumeh\|Kavoosi, Fraidoon\|Roustazadeh, Abazar\|Golestan, Fatemeh
PMID:	29951358

54.
Journal:	Cancer Lett. 2018 Oct 10;434:33-41.
Title:	Telomerase reverse transcriptase regulates DNMT3B expression/aberrant DNA methylation phenotype and AKT activation in hepatocellular carcinoma.
Author:	Yu, Jingya\|Yuan, Xiaotian\|Sjoholm, Louise\|Liu, Tiantian\|Kong, Feng\|Ekstrom, Tomas J\|Bjorkholm, Magnus\|Xu, Dawei
PMID:	30017965