Primary Site >> Colorectal Cancer

Gene >> CYP2C9

Journal: Carcinogenesis. 2001 Aug;22(8):1323-6.
Title: Association of CYP2C9 genotypes leading to high enzyme activity and colorectal cancer risk.
Author: Martinez, C|Garcia-Martin, E|Ladero, J M|Sastre, J|Garcia-Gamito, F|Diaz-Rubio, M|Agundez, J A
PMID: 11470765
Journal: Cancer Res. 2001 May 1;61(9):3566-9.
Title: CYP2C9 and UGT1A6 genotypes modulate the protective effect of aspirin on colon adenoma risk.
Author: Bigler, J|Whitton, J|Lampe, J W|Fosdick, L|Bostick, R M|Potter, J D
PMID: 11325819
Journal: Carcinogenesis. 2002 Apr;23(4):665; author reply 667-8.
Title: Association of CYP2C9 genotypes leading to high enzyme activity and colorectal cancer risk.
Author: Yasar, Umit|Eliasson, Erik|Dahl, Marja-Liisa
PMID: 11960920
Journal: Carcinogenesis. 2002 Nov;23(11):1839-49.
Title: A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer.
Author: Sachse, Christoph|Smith, Gillian|Wilkie, Murray J V|Barrett, Jennifer H|Waxman, Robin|Sullivan, Frank|Forman, David|Bishop, D Timothy|Wolf, C Roland
PMID: 12419832
Journal: Cancer Chemother Pharmacol. 2005 Sep;56(3):248-54. Epub 2005 Apr 27.
Title: P450 induction alters paclitaxel pharmacokinetics and tissue distribution with multiple dosing.
Author: Gustafson, Daniel L|Long, Michael E|Bradshaw, Erica L|Merz, Andrea L|Kerzic, Patrick J
PMID: 15856231
Journal: Mol Carcinog. 2005 Sep;44(1):21-30.
Title: Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study.
Author: Tranah, Gregory J|Chan, Andrew T|Giovannucci, Edward|Ma, Jing|Fuchs, Charles|Hunter, David J
PMID: 15924351
Journal: Pharmacogenet Genomics. 2005 Aug;15(8):535-46.
Title: A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer.
Author: Landi, Stefano|Gemignani, Federica|Moreno, Victor|Gioia-Patricola, Lydie|Chabrier, Amelie|Guino, Elisabeth|Navarro, Matilde|de Oca, Javier|Capella, Gabriel|Canzian, Federico
PMID: 16006997
Journal: Pharmacogenet Genomics. 2005 Oct;15(10):713-21.
Title: No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARdelta and PPARgamma act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma.
Author: McGreavey, Louise E|Turner, Faye|Smith, Gillian|Boylan, Katherine|Timothy Bishop, D|Forman, David|Roland Wolf, C|Barrett, Jennifer H
PMID: 16141797
Journal: Basic Clin Pharmacol Toxicol. 2006 Feb;98(2):197-200.
Title: Inhibitory effect of 5-fluorouracil on cytochrome P450 2C9 activity in cancer patients.
Author: Gunes, Arzu|Coskun, Ugur|Boruban, Cem|Gunel, Nazan|Babaoglu, Melih O|Sencan, Orhan|Bozkurt, Atila|Rane, Anders|Hassan, Moustapha|Zengil, Hakan|Yasar, Umit
PMID: 16445595
Journal: Clin Gastroenterol Hepatol. 2006 Jul;4(7):894-901. Epub 2006 Jun 22.
Title: Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer prevention.
Author: Samowitz, Wade S|Wolff, Roger K|Curtin, Karen|Sweeney, Carol|Ma, Khe-Ni|Andersen, Kristen|Levin, Theodore R|Slattery, Martha L
PMID: 16797247
Journal: Clin Chim Acta. 2007 May 1;380(1-2):191-6. Epub 2007 Feb 22.
Title: The association of CYP2C9 gene polymorphisms with colorectal carcinoma in Han Chinese.
Author: Liao, Ling-Hong|Zhang, Hao|Lai, Man-Po|Lau, Kwok-Wai|Lai, Albert Kai-Cheong|Zhang, Jin-Hui|Wang, Qi|Wei, Wei|Chai, Jian-Hua|Lung, Maria Li|Tai, Susan S W|Wu, Madeline
PMID: 17368604
Journal: Cancer Epidemiol Biomarkers Prev. 2007 Jul;16(7):1460-7.
Title: Combinations of cytochrome P450 gene polymorphisms enhancing the risk for sporadic colorectal cancer related to red meat consumption.
Author: Kury, Sebastien|Buecher, Bruno|Robiou-du-Pont, Sebastien|Scoul, Catherine|Sebille, Veronique|Colman, Helene|Le Houerou, Claire|Le Neel, Tanguy|Bourdon, Jeremie|Faroux, Roger|Ollivry, Jean|Lafraise, Bernard|Chupin, Louis-Dominique|Bezieau, Stephane
PMID: 17627011
Journal: Clin Ther. 2008 Aug;30(8):1385-407.
Title: Drug interactions between chemotherapeutic regimens and antiepileptics.
Author: Yap, Kevin Yi-Lwern|Chui, Wai Keung|Chan, Alexandre
PMID: 18803983
Journal: Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3098-107.
Title: Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk.
Author: Cotterchio, Michelle|Boucher, Beatrice A|Manno, Michael|Gallinger, Steven|Okey, Allan B|Harper, Patricia A
PMID: 18990750
Journal: Invest New Drugs. 2008 Feb;26(1):25-34.
Title: Pharmacological evaluation of C-3 modified Betulinic acid derivatives with potent anticancer activity.
Author: Rajendran, Praveen|Jaggi, Manu|Singh, Manoj K|Mukherjee, Rama|Burman, Anand C
PMID: 17851638
Journal: Neth J Med. 2009 Apr;67(4):134-41.
Title: No modification of the beneficial effect of NSAIDs on colorectal cancer by CYP2C9 genotype.
Author: Siemes, C|Eijgelsheim, M|Dieleman, J P|van Schaik, R H N|Uitterlinden, A G|van Duijn, C M|Hofman, A|Coebergh, J W W|Stricker, B H Ch|Visser, L E
PMID: 19581657
Journal: Am J Epidemiol. 2010 Nov 1;172(9):1000-14.
Title: Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk.
Author: Cleary, Sean P|Cotterchio, Michelle|Shi, Ellen|Gallinger, Steven|Harper, Patricia
PMID: 20937634
Journal: Endocr Relat Cancer. 2011 Mar 9;18(2):265-76.
Title: Association of genetic polymorphisms in ESR2, HSD17B1, ABCB1, and SHBG genes with colorectal cancer risk.
Author: Sainz, J|Rudolph, A|Hein, R|Hoffmeister, M|Buch, S|von Schonfels, W|Hampe, J|Schafmayer, C|Volzke, H|Frank, B|Brenner, H|Forsti, A|Hemminki, K|Chang-Claude, J
PMID: 21317201
Journal: Endocr Relat Cancer. 2011 Jun 8;18(3):371-84.
Title: Modification of menopausal hormone therapy-associated colorectal cancer risk by polymorphisms in sex steroid signaling, metabolism and transport related genes.
Author: Rudolph, Anja|Sainz, Juan|Hein, Rebecca|Hoffmeister, Michael|Frank, Bernd|Forsti, Asta|Brenner, Hermann|Hemminki, Kari|Chang-Claude, Jenny
PMID: 21490239
Journal: PLoS One. 2012;7(11):e49134.
Title: Meta-analysis of cytochrome P-450 2C9 polymorphism and colorectal cancer risk.
Author: Liang, Shuo|Hu, Jinsong|Cao, Weijun|Cai, Sanjun
PMID: 23145098
Journal: Front Genet. 2012 Dec 3;3:278.
Title: Analysis of the Functional Polymorphism in the Cytochrome P450 CYP2C8 Gene rs11572080 with Regard to Colorectal Cancer Risk.
Author: Ladero, Jose M|Agundez, Jose A G|Martinez, Carmen|Amo, Gemma|Ayuso, Pedro|Garcia-Martin, Elena
PMID: 23420707
Journal: PLoS One. 2013;8(4):e60607.
Title: Quantitative assessment of the effect of cytochrome P450 2C9 gene polymorphism and colorectal cancer.
Author: Zhao, Yuan|Han, Yusong|Zhang, Liang|Wang, Yichao|Ma, Yushui|Zhang, Feng|Fu, Da|Wang, Xiaofeng
PMID: 23577132
Journal: Tumour Biol. 2014 May;35(5):4317-22.
Title: Association between cytochrome P450 2C9 gene polymorphisms and colorectal cancer susceptibility: evidence from 16 case-control studies.
Author: Wang, Hong|Ren, Li|He, Yifeng|Wei, Ye|Chen, Zenggan|Yang, Weige|Fu, Yipeng|Xu, Xiaoyue|Fu, Weigao|Hu, Guangfu|Lou, Wenhui
PMID: 24414392
Journal: Genet Test Mol Biomarkers. 2014 Apr;18(4):223-8.
Title: Genetic variations in the xenobiotic-metabolizing enzymes CYP1A1, CYP1A2, CYP2C9, CYP2C19 and susceptibility to colorectal cancer among Turkish people.
Author: Ozhan, Gul|Mutur, Mine|Ercan, Gulcin|Alpertunga, Buket
PMID: 24527758
Journal: Genes Chromosomes Cancer. 2014 Jul;53(7):568-78.
Title: Genetic variation in UGT genes modify the associations of NSAIDs with risk of colorectal cancer: colon cancer family registry.
Author: Scherer, Dominique|Koepl, Lisel M|Poole, Elizabeth M|Balavarca, Yesilda|Xiao, Liren|Baron, John A|Hsu, Li|Coghill, Anna E|Campbell, Peter T|Kleinstein, Sarah E|Figueiredo, Jane C|Lampe, Johanna W|Buck, Katharina|Potter, John D|Kulmacz, Richard J|Jenkins,
PMID: 24677636
Journal: J Pharm Health Care Sci. 2016 Jul 8;2:15.
Title: Elevated prothrombin time/international normalized ratio associated with concurrent administration of regorafenib and warfarin in a patient with advanced colorectal cancer.
Author: Kitade, Hironori|Hiromasa-Yamasaki, Azusa|Hokkoku, Kengo|Mori, Mitsue|Watanabe, Michio|Nakai, Masuo|Yano, Seiji
PMID: 27398225
Journal: Br J Cancer. 2017 Sep 26;117(7):965-973.
Title: Pharmacogenetic determinants of outcomes on triplet hepatic artery infusion and intravenous cetuximab for liver metastases from colorectal cancer (European trial OPTILIV, NCT00852228).
Author: Levi, Francis|Karaboue, Abdoulaye|Saffroy, Raphael|Desterke, Christophe|Boige, Valerie|Smith, Denis|Hebbar, Mohamed|Innominato, Pasquale|Taieb, Julien|Carvalho, Carlos|Guimbaud, Rosine|Focan, Christian|Bouchahda, Mohamed|Adam, Rene|Ducreux, Michel|Milano,
PMID: 28817838