Literatures

Primary Site >> Colorectal Cancer

Gene >> CTLA4

1.
Journal:	J Immunol. 1997 Nov 15;159(10):5168-73.
Title:	Prevention of immunotoxin-induced immunogenicity by coadministration with CTLA4Ig enhances antitumor efficacy.
Author:	Siegall, C B\|Haggerty, H G\|Warner, G L\|Chace, D\|Mixan, B\|Linsley, P S\|Davidson, T
PMID:	9366448

2.
Journal:	Cancer Res. 2004 Aug 1;64(15):5407-14.
Title:	Two distinct pathways of immuno-modulation improve potency of p53 immunization in rejecting established tumors.
Author:	Daftarian, Pirouz\|Song, Guang-Yun\|Ali, Saima\|Faynsod, Moshe\|Longmate, Jeff\|Diamond, Don J\|Ellenhorn, Joshua D I
PMID:	15289349

3.
Journal:	Dig Liver Dis. 2005 Mar;37(3):170-5.
Title:	CTLA4 gene polymorphism in Italian patients with colorectal adenoma and cancer.
Author:	Solerio, E\|Tappero, G\|Iannace, L\|Matullo, G\|Ayoubi, M\|Parziale, A\|Cicilano, M\|Sansoe, G\|Framarin, L\|Vineis, P\|Rosina, F
PMID:	15888281

4.
Journal:	Cancer Res. 2006 Feb 15;66(4):2442-50.
Title:	Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma.
Author:	Tirapu, Inigo\|Huarte, Eduardo\|Guiducci, Cristiana\|Arina, Ainhoa\|Zaratiegui, Mikel\|Murillo, Oihana\|Gonzalez, Alvaro\|Berasain, Carmen\|Berraondo, Pedro\|Fortes, Puri\|Prieto, Jesus\|Colombo, Mario P\|Chen, Lieping\|Melero, Ignacio
PMID:	16489051

5.
Journal:	Clin Cancer Res. 2007 Feb 1;13(3):958-64.
Title:	A pilot study of CTLA-4 blockade after cancer vaccine failure in patients with advanced malignancy.
Author:	O'Mahony, Deirdre\|Morris, John C\|Quinn, Cate\|Gao, Wendy\|Wilson, Wyndham H\|Gause, Barry\|Pittaluga, Stefania\|Neelapu, Sattva\|Brown, Margaret\|Fleisher, Thomas A\|Gulley, James L\|Schlom, Jeffrey\|Nussenblatt, Robert\|Albert, Paul\|Davis, Thomas A\|Lowy, Israel\|Pet
PMID:	17289891

6.
Journal:	Hum Immunol. 2007 Aug;68(8):698-704. Epub 2007 Jun 6.
Title:	High incidence of CTLA-4 AA (CT60) polymorphism in renal cell cancer.
Author:	Cozar, Jose M\|Romero, Jose M\|Aptsiauri, Natalia\|Vazquez, Fernando\|Vilchez, Jose R\|Tallada, Miguel\|Garrido, Federico\|Ruiz-Cabello, Francisco
PMID:	17678726

7.
Journal:	Curr Opin Mol Ther. 2007 Oct;9(5):505-14.
Title:	Tremelimumab, a fully human monoclonal IgG2 antibody against CTLA4 for the potential treatment of cancer.
Author:	Tarhini, Ahmad A\|Kirkwood, John M
PMID:	17932815

8.
Journal:	World J Gastroenterol. 2007 Nov 28;13(44):5822-31.
Title:	Immunotherapy and immunoescape in colorectal cancer.
Author:	Mazzolini, Guillermo\|Murillo, Oihana\|Atorrasagasti, Catalina\|Dubrot, Juan\|Tirapu, Inigo\|Rizzo, Miguel\|Arina, Ainhoa\|Alfaro, Carlos\|Azpilicueta, Arantza\|Berasain, Carmen\|Perez-Gracia, Jose L\|Gonzalez, Alvaro\|Melero, Ignacio
PMID:	17990348

9.
Journal:	J Gastroenterol Hepatol. 2007 Dec;22(12):2283-7.
Title:	CTLA-4 gene promoter and exon 1 polymorphisms in Iranian patients with gastric and colorectal cancers.
Author:	Hadinia, Abolghasem\|Hossieni, Seyed Vahid\|Erfani, Nasrollah\|Saberi-Firozi, Mehdi\|Fattahi, Mohammad Javad\|Ghaderi, Abbas
PMID:	18031393

10.
Journal:	Gastrointest Cancer Res. 2008 Jul;2(4 Suppl):S20-2.
Title:	Colorectal Cancer Treatment: What's Next? (or: Is There Life After EGFR and VEGF?).
Author:	Saltz, Leonard
PMID:	19343143

11.
Journal:	Infect Immun. 2008 Dec;76(12):5834-42.
Title:	Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis.
Author:	Watanabe, Koichiro\|Rao, Varada P\|Poutahidis, Theofilos\|Rickman, Barry H\|Ohtani, Masahiro\|Xu, Shilu\|Rogers, Arlin B\|Ge, Zhongming\|Horwitz, Bruce H\|Fujioka, Toshio\|Erdman, Susan E\|Fox, James G
PMID:	18824539

12.
Journal:	Expert Opin Biol Ther. 2008 Oct;8(10):1583-93.
Title:	Tremelimumab (CP-675,206): a fully human anticytotoxic T lymphocyte-associated antigen 4 monoclonal antibody for treatment of patients with advanced cancers.
Author:	Tarhini, Ahmad A\|Kirkwood, John M
PMID:	18774925

13.
Journal:	Clin Cancer Res. 2009 Sep 1;15(17):5379-88.
Title:	Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody.
Author:	Dewan, M Zahidunnabi\|Galloway, Ashley E\|Kawashima, Noriko\|Dewyngaert, J Keith\|Babb, James S\|Formenti, Silvia C\|Demaria, Sandra
PMID:	19706802

14.
Journal:	Int J Colorectal Dis. 2010 Jan;25(1):39-45.
Title:	CTLA-4 +49A>G polymorphism is associated with the risk but not with the progression of colorectal cancer in Chinese.
Author:	Qi, Peng\|Ruan, Can-ping\|Wang, Hao\|Zhou, Fei-guo\|Xu, Xin-yun\|Gu, Xing\|Zhao, Yun-peng\|Dou, Tong-hai\|Gao, Chun-fang
PMID:	19787358

15.
Journal:	J Cancer Res Clin Oncol. 2010 Sep;136(9):1445-52.
Title:	Peripheral blood gene expression of B7 and CD28 family members associated with tumor progression and microscopic lymphovascular invasion in colon cancer patients.
Author:	Lee, Hyunji\|Kim, Ji Hyun\|Yang, Sung Yeun\|Kong, Jihye\|Oh, Minkyung\|Jeong, Dae Hoon\|Chung, Jae-Il\|Bae, Ki Beom\|Shin, Jin Yong\|Hong, Kwan Hee\|Choi, Inhak
PMID:	20140740

16.
Journal:	Scand J Immunol. 2010 Feb;71(2):70-82.
Title:	Combination of CTL-associated antigen-4 blockade and depletion of CD25 regulatory T cells enhance tumour immunity of dendritic cell-based vaccine in a mouse model of colon cancer.
Author:	Saha, Asim\|Chatterjee, S K
PMID:	20384858

17.
Journal:	Clin Cancer Res. 2010 May 15;16(10):2781-91.
Title:	Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals.
Author:	Mitsui, Jun\|Nishikawa, Hiroyoshi\|Muraoka, Daisuke\|Wang, Linan\|Noguchi, Takuro\|Sato, Eiichi\|Kondo, Satoshi\|Allison, James P\|Sakaguchi, Shimon\|Old, Lloyd J\|Kato, Takuma\|Shiku, Hiroshi
PMID:	20460483

18.
Journal:	J Clin Oncol. 2010 Jul 20;28(21):3485-90.
Title:	Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer.
Author:	Chung, Ki Y\|Gore, Ira\|Fong, Lawrence\|Venook, Alan\|Beck, Stephen B\|Dorazio, Prudence\|Criscitiello, Peggy J\|Healey, Diane I\|Huang, Bo\|Gomez-Navarro, Jesus\|Saltz, Leonard B
PMID:	20498386

19.
Journal:	Drugs R D. 2010;10(2):123-32.
Title:	Tremelimumab.
Author:
PMID:	20698721

20.
Journal:	Clin Cancer Res. 2010 Dec 15;16(24):6019-28.
Title:	Simultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma model.
Author:	Yu, Ping\|Steel, Jason C\|Zhang, Meili\|Morris, John C\|Waldmann, Thomas A
PMID:	20924130

21.
Journal:	Clin Dev Immunol. 2011;2011:894704.
Title:	The immune response to tumors as a tool toward immunotherapy.
Author:	Pandolfi, F\|Cianci, R\|Pagliari, D\|Casciano, F\|Bagala, C\|Astone, A\|Landolfi, R\|Barone, C
PMID:	22190975

22.
Journal:	Gastroenterology. 2011 Jun;140(7):2019-30.
Title:	Human colonic myofibroblasts promote expansion of CD4+ CD25high Foxp3+ regulatory T cells.
Author:	Pinchuk, Irina V\|Beswick, Ellen J\|Saada, Jamal I\|Boya, Gushyalatha\|Schmitt, David\|Raju, Gottumukkala S\|Brenmoehl, Julia\|Rogler, Gerhard\|Reyes, Victor E\|Powell, Don W
PMID:	21376048

23.
Journal:	PLoS One. 2012;7(2):e30695.
Title:	Accumulation of CCR4(+)CTLA-4 FOXP3(+)CD25(hi) regulatory T cells in colon adenocarcinomas correlate to reduced activation of conventional T cells.
Author:	Svensson, Helena\|Olofsson, Veronica\|Lundin, Samuel\|Yakkala, Chakradhar\|Bjorck, Stellan\|Borjesson, Lars\|Gustavsson, Bengt\|Quiding-Jarbrink, Marianne
PMID:	22319577

24.
Journal:	JOP. 2012 Mar 10;13(2):166-8.
Title:	Novel agents in early phase clinical studies on refractory pancreatic cancer.
Author:	Strimpakos, Alexios S\|Syrigos, Kostas N\|Saif, Muhammad Wasif
PMID:	22406592

25.
Journal:	Pathol Biol (Paris). 2012 Aug;60(4):223-8.
Title:	[Therapeutic monoclonal antibodies in oncology].
Author:	Bouzid, K\|Bedairia, N\|Marty, M
PMID:	22863361

26.
Journal:	PLoS One. 2013;8(3):e58006.
Title:	Tim-3 expression defines regulatory T cells in human tumors.
Author:	Yan, Jing\|Zhang, Yi\|Zhang, Jing-Ping\|Liang, Jing\|Li, Lian\|Zheng, Limin
PMID:	23526963

27.
Journal:	Cancer Immunol Immunother. 2013 Sep;62(9):1533-45.
Title:	Synergy between chemotherapeutic agents and CTLA-4 blockade in preclinical tumor models.
Author:	Jure-Kunkel, Maria\|Masters, Gregg\|Girit, Emel\|Dito, Gennaro\|Lee, Francis\|Hunt, John T\|Humphrey, Rachel
PMID:	23873089

28.
Journal:	Onco Targets Ther. 2013 Aug 20;6:1119-27.
Title:	Influence of the oncolytic parvovirus H-1, CTLA-4 antibody tremelimumab and cytostatic drugs on the human immune system in a human in vitro model of colorectal cancer cells.
Author:	Heinrich, Bernd\|Goepfert, Katrin\|Delic, Maike\|Galle, Peter R\|Moehler, Markus
PMID:	23986643

29.
Journal:	Acta Neuropathol. 2014 Dec;128(6):879-91.
Title:	Predictive molecular markers in metastases to the central nervous system: recent advances and future avenues.
Author:	Berghoff, Anna Sophie\|Bartsch, Rupert\|Wohrer, Adelheid\|Streubel, Berthold\|Birner, Peter\|Kros, Johan M\|Brastianos, Priscilla K\|von Deimling, Andreas\|Preusser, Matthias
PMID:	25287912

30.
Journal:	J Immunother Cancer. 2014 Nov 18;2(1):38.
Title:	Detailed characterization of tumor infiltrating lymphocytes in two distinct human solid malignancies show phenotypic similarities.
Author:	Kovacsovics-Bankowski, Magdalena\|Chisholm, Lana\|Vercellini, Jonna\|Tucker, Christopher G\|Montler, Ryan\|Haley, Daniel\|Newell, Philippa\|Ma, Jun\|Tseng, Paul\|Wolf, Ronald\|Vetto, John T\|Hammill, Chet\|Hansen, Paul\|Weinberg, Andrew D
PMID:	25436113

31.
Journal:	Cancer Res. 2014 Aug 15;74(16):4258-69.
Title:	Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer.
Author:	Pastille, Eva\|Bardini, Katrin\|Fleissner, Diana\|Adamczyk, Alexandra\|Frede, Annika\|Wadwa, Munisch\|von Smolinski, Dorthe\|Kasper, Stefan\|Sparwasser, Tim\|Gruber, Achim D\|Schuler, Martin\|Sakaguchi, Shimon\|Roers, Axel\|Muller, Werner\|Hansen, Wiebke\|Buer, Jan\|West
PMID:	24906621

32.
Journal:	World J Gastroenterol. 2014 Apr 14;20(14):3738-50.
Title:	Colorectal cancer and immunity: what we know and perspectives.
Author:	Pernot, Simon\|Terme, Magali\|Voron, Thibault\|Colussi, Orianne\|Marcheteau, Elie\|Tartour, Eric\|Taieb, Julien
PMID:	24833840

33.
Journal:	J Immunother. 2014 Jan;37(1):1-7.
Title:	CTLA-4 blockade enhances antitumor immunity of intratumoral injection of immature dendritic cells into irradiated tumor in a mouse colon cancer model.
Author:	Son, Cheol-Hun\|Bae, Jae-Ho\|Shin, Dong-Yeok\|Lee, Hong-Rae\|Choi, Yoo-Jin\|Jo, Wol-Soon\|Ho Jung, Min\|Kang, Chi-Dug\|Yang, Kwangmo\|Park, You-Soo
PMID:	24316550

34.
Journal:	Mucosal Immunol. 2014 Mar;7(2):428-39.
Title:	Highly prevalent colorectal cancer-infiltrating LAP(+) Foxp3(-) T cells exhibit more potent immunosuppressive activity than Foxp3(+) regulatory T cells.
Author:	Scurr, M\|Ladell, K\|Besneux, M\|Christian, A\|Hockey, T\|Smart, K\|Bridgeman, H\|Hargest, R\|Phillips, S\|Davies, M\|Price, D\|Gallimore, A\|Godkin, A
PMID:	24064667

35.
Journal:	Oncoimmunology. 2015 Jun 5;4(7):e1058597.
Title:	Colorectal cancer: the first neoplasia found to be under immunosurveillance and the last one to respond to immunotherapy?
Author:	Kroemer, Guido\|Galluzzi, Lorenzo\|Zitvogel, Laurence\|Fridman, Wolf Herve
PMID:	26140250

36.
Journal:	Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15408-13.
Title:	STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity.
Author:	Demaria, Olivier\|De Gassart, Aude\|Coso, Sanja\|Gestermann, Nicolas\|Di Domizio, Jeremy\|Flatz, Lukas\|Gaide, Olivier\|Michielin, Olivier\|Hwu, Patrick\|Petrova, Tatiana V\|Martinon, Fabio\|Modlin, Robert L\|Speiser, Daniel E\|Gilliet, Michel
PMID:	26607445

37.
Journal:	Anticancer Res. 2015 Oct;35(10):5391-400.
Title:	Individual and Combined Effects of CTLA4-CD28 Variants and Oxidant-Antioxidant Status on the Development of Colorectal Cancer.
Author:	Kucukhuseyin, Ozlem\|Turan, Saime\|Yanar, Karolin\|Arikan, Soykan\|Duzkoylu, Yigit\|Aydin, Seval\|Cakatay, Ufuk\|Mezani, Brunilda\|Farooqi, Ammad Ahmad\|Isitmangil, Gulbu Aydinoglu\|Kiran, Bayram\|Cacina, Canan\|Yenilmez, Ezgi Nurdan\|Ergen, Arzu\|Zeybek, Umit\|Yaylim,
PMID:	26408701

38.
Journal:	Transl Res. 2015 Dec;166(6):721-732.e1.
Title:	Tumor-infiltrating lymphocytes, forkhead box P3, programmed death ligand-1, and cytotoxic T lymphocyte-associated antigen-4 expressions before and after neoadjuvant chemoradiation in rectal cancer.
Author:	Teng, Feifei\|Meng, Xiangjiao\|Kong, Li\|Mu, Dianbin\|Zhu, Hui\|Liu, Sujing\|Zhang, Jianbo\|Yu, Jinming
PMID:	26209749

39.
Journal:	Clin Cancer Res. 2015 Dec 15;21(24):5543-51.
Title:	Defining Effective Combinations of Immune Checkpoint Blockade and Oncolytic Virotherapy.
Author:	Rojas, Juan J\|Sampath, Padma\|Hou, Weizhou\|Thorne, Steve H
PMID:	26187615

40.
Journal:	Int J Clin Exp Med. 2015 Mar 15;8(3):3752-60. eCollection 2015.
Title:	Association between cytotoxic T-lymphocyte antigen-4 +49A/G polymorphism and colorectal cancer risk: a meta-analysis.
Author:	He, Lei\|Deng, Tao\|Luo, He-Sheng
PMID:	26064271

41.
Journal:	Biomaterials. 2015 Aug;61:33-40.
Title:	Polymeric microparticles for sustained and local delivery of antiCD40 and antiCTLA-4 in immunotherapy of cancer.
Author:	Rahimian, Sima\|Fransen, Marieke F\|Kleinovink, Jan Willem\|Amidi, Maryam\|Ossendorp, Ferry\|Hennink, Wim E
PMID:	25993015

42.
Journal:	Oncoimmunology. 2015 Apr 2;4(3):e976052.
Title:	An immunogenomic stratification of colorectal cancer: Implications for development of targeted immunotherapy.
Author:	Lal, Neeraj\|Beggs, Andrew D\|Willcox, Benjamin E\|Middleton, Gary W
PMID:	25949894

43.
Journal:	Oncoimmunology. 2015 Feb 3;4(1):e985082.
Title:	Immune signature of tumor infiltrating immune cells in renal cancer.
Author:	Geissler, Katharina\|Fornara, Paolo\|Lautenschlager, Christine\|Holzhausen, Hans-Jurgen\|Seliger, Barbara\|Riemann, Dagmar
PMID:	25949868

44.
Journal:	Oncotarget. 2015 Apr 10;6(10):8261-70.
Title:	Peripheral myeloid-derived suppressor and T regulatory PD-1 positive cells predict response to neoadjuvant short-course radiotherapy in rectal cancer patients.
Author:	Napolitano, Maria\|D'Alterio, Crescenzo\|Cardone, Eleonora\|Trotta, Anna Maria\|Pecori, Biagio\|Rega, Daniela\|Pace, Ugo\|Scala, Dario\|Scognamiglio, Giosue\|Tatangelo, Fabiana\|Cacciapuoti, Carmela\|Pacelli, Roberto\|Delrio, Paolo\|Scala, Stefania
PMID:	25823653

45.
Journal:	Int J Clin Exp Med. 2015 Jan 15;8(1):650-7. eCollection 2015.
Title:	Association between CTLA-4 rs231775 polymorphism and risk of colorectal cancer: a meta analysis.
Author:	Wang, Lijie\|Jing, Fangfang\|Su, Dan\|Zhang, Tingting\|Yang, Bo\|Jiao, Shunchang\|Hu, Yi\|Bai, Li
PMID:	25785040

46.
Journal:	Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E966-72.
Title:	Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK.
Author:	Sagiv-Barfi, Idit\|Kohrt, Holbrook E K\|Czerwinski, Debra K\|Ng, Patrick P\|Chang, Betty Y\|Levy, Ronald
PMID:	25730880

47.
Journal:	Int J Immunogenet. 2015 Apr;42(2):93-9.
Title:	The association of CTLA-4 A49G polymorphism with colorectal cancer risk in a Chinese Han population.
Author:	Wang, Y\|Wang, X\|Zhao, R
PMID:	25689638

48.
Journal:	Oncotarget. 2015 Aug 21;6(24):20058-69.
Title:	CD80-CD28 signaling controls the progression of inflammatory colorectal carcinogenesis.
Author:	Scarpa, Marco\|Brun, Paola\|Scarpa, Melania\|Morgan, Susan\|Porzionato, Andrea\|Kotsafti, Andromachi\|Bortolami, Marina\|Buda, Andrea\|D'Inca, Renata\|Macchi, Veronica\|Sturniolo, Giacomo C\|Rugge, Massimo\|Bardini, Romeo\|Castagliuolo, Ignazio\|Angriman, Imerio\|Castor
PMID:	25595911

49.
Journal:	Cancer Discov. 2015 Jan;5(1):16-8.
Title:	The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy.
Author:	Xiao, Yanping\|Freeman, Gordon J
PMID:	25583798

50.
Journal:	Nature. 2015 Jan 15;517(7534):386-90.
Title:	CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Author:	Huang, Yu-Hwa\|Zhu, Chen\|Kondo, Yasuyuki\|Anderson, Ana C\|Gandhi, Amit\|Russell, Andrew\|Dougan, Stephanie K\|Petersen, Britt-Sabina\|Melum, Espen\|Pertel, Thomas\|Clayton, Kiera L\|Raab, Monika\|Chen, Qiang\|Beauchemin, Nicole\|Yazaki, Paul J\|Pyzik, Michal\|Ostrowski
PMID:	25363763

51.
Journal:	Cancer Discov. 2015 Jan;5(1):43-51.
Title:	The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints.
Author:	Llosa, Nicolas J\|Cruise, Michael\|Tam, Ada\|Wicks, Elizabeth C\|Hechenbleikner, Elizabeth M\|Taube, Janis M\|Blosser, Richard L\|Fan, Hongni\|Wang, Hao\|Luber, Brandon S\|Zhang, Ming\|Papadopoulos, Nickolas\|Kinzler, Kenneth W\|Vogelstein, Bert\|Sears, Cynthia L\|Ander
PMID:	25358689

52.
Journal:	Cancer Immunol Res. 2015 Sep;3(9):1052-62.
Title:	Identification and Characterization of MEDI4736, an Antagonistic Anti-PD-L1 Monoclonal Antibody.
Author:	Stewart, Ross\|Morrow, Michelle\|Hammond, Scott A\|Mulgrew, Kathy\|Marcus, Danielle\|Poon, Edmund\|Watkins, Amanda\|Mullins, Stefanie\|Chodorge, Matthieu\|Andrews, John\|Bannister, David\|Dick, Emily\|Crawford, Nicola\|Parmentier, Julie\|Alimzhanov, Marat\|Babcook, John
PMID:	25943534

53.
Journal:	Onco Targets Ther. 2016 Mar 31;9:1899-920.
Title:	Advances in targeted and immunobased therapies for colorectal cancer in the genomic era.
Author:	Seow, Heng Fong\|Yip, Wai Kien\|Fifis, Theodora
PMID:	27099521

54.
Journal:	PLoS One. 2016 Sep 9;11(9):e0161779.
Title:	Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology.
Author:	Selby, Mark J\|Engelhardt, John J\|Johnston, Robert J\|Lu, Li-Sheng\|Han, Minhua\|Thudium, Kent\|Yao, Dapeng\|Quigley, Michael\|Valle, Jose\|Wang, Changyu\|Chen, Bing\|Cardarelli, Pina M\|Blanset, Diann\|Korman, Alan J
PMID:	27610613

55.
Journal:	Clin Colorectal Cancer. 2016 Dec;15(4):285-291.
Title:	The Potential Value of Immunotherapy in Colorectal Cancers: Review of the Evidence for Programmed Death-1 Inhibitor Therapy.
Author:	Toh, James W T\|de Souza, Paul\|Lim, Stephanie H\|Singh, Puneet\|Chua, Wei\|Ng, Weng\|Spring, Kevin J
PMID:	27553906

56.
Journal:	Zhonghua Zhong Liu Za Zhi. 2016 Aug;38(8):596-601.
Title:	[Phenotypic characteristics of LAP(+) CD4(+) T lymphocytes in colorectal cancer tissues].
Author:	Zhong, W\|Jiang, Z Y\|Zhong, S B\|Zhang, L C\|Huang, J H\|Zhang, S\|Chen, L S\|Cao, Y F
PMID:	27531479

57.
Journal:	Oncoimmunology. 2016 Mar 10;5(5):e1141857.
Title:	The clinical impact of ICOS signal in colorectal cancer patients.
Author:	Zhang, Yan\|Luo, Yang\|Qin, Shao-Lan\|Mu, Yi-Fei\|Qi, Yang\|Yu, Min-Hao\|Zhong, Ming
PMID:	27467961

58.
Journal:	Oncol Res Treat. 2016;39(6):346-50.
Title:	Immunotherapy of Colorectal Cancer.
Author:	Jager, Dirk\|Halama, Niels\|Zornig, Inka\|Klug, Paula\|Krauss, Jurgen\|Haag, Georg-Martin
PMID:	27259331

59.
Journal:	J Nucl Med. 2016 Oct;57(10):1607-1611.
Title:	Quantitative CD3 PET Imaging Predicts Tumor Growth Response to Anti-CTLA-4 Therapy.
Author:	Larimer, Benjamin M\|Wehrenberg-Klee, Eric\|Caraballo, Alexander\|Mahmood, Umar
PMID:	27230929

60.
Journal:	Eur J Cancer. 2016 May;59:160-170.
Title:	Immunotherapy in gastrointestinal cancer: Recent results, current studies and future perspectives.
Author:	Moehler, Markus\|Delic, Maike\|Goepfert, Katrin\|Aust, Daniela\|Grabsch, Heike I\|Halama, Niels\|Heinrich, Bernd\|Julie, Catherine\|Lordick, Florian\|Lutz, Manfred P\|Mauer, Murielle\|Alsina Maqueda, Maria\|Schild, Hansjoerg\|Schimanski, Carl C\|Wagner, Anna-Dorothea\|R
PMID:	27039171

61.
Journal:	Oncotarget. 2016 Mar 29;7(13):17035-46.
Title:	Intravenous administration of the selective toll-like receptor 7 agonist DSR-29133 leads to anti-tumor efficacy in murine solid tumor models which can be potentiated by combination with fractionated radiotherapy.
Author:	Dovedi, Simon J\|Adlard, Amy L\|Ota, Yosuke\|Murata, Masashi\|Sugaru, Eiji\|Koga-Yamakawa, Erina\|Eguchi, Ken\|Hirose, Yuko\|Yamamoto, Setsuko\|Umehara, Hiroki\|Honeychurch, Jamie\|Cheadle, Eleanor J\|Hughes, Gareth\|Jewsbury, Philip J\|Wilkinson, Robert W\|Stratford, I
PMID:	26959743

62.
Journal:	Oncotarget. 2016 Mar 29;7(13):16130-45.
Title:	IL-15 superagonist/IL-15RalphaSushi-Fc fusion complex (IL-15SA/IL-15RalphaSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas.
Author:	Kim, Peter S\|Kwilas, Anna R\|Xu, Wenxin\|Alter, Sarah\|Jeng, Emily K\|Wong, Hing C\|Schlom, Jeffrey\|Hodge, James W
PMID:	26910920

63.
Journal:	J Immunother Cancer. 2017 Aug 15;5(1):63.
Title:	The MEK inhibitor selumetinib complements CTLA-4 blockade by reprogramming the tumor immune microenvironment.
Author:	Poon, Edmund\|Mullins, Stefanie\|Watkins, Amanda\|Williams, Geoffrey S\|Koopmann, Jens-Oliver\|Di Genova, Gianfranco\|Cumberbatch, Marie\|Veldman-Jones, Margaret\|Grosskurth, Shaun E\|Sah, Vasu\|Schuller, Alwin\|Reimer, Corrine\|Dovedi, Simon J\|Smith, Paul D\|Stewart,
PMID:	28807001

64.
Journal:	Surg Oncol. 2017 Dec;26(4):368-376.
Title:	The role of intestinal bacteria in the development and progression of gastrointestinal tract neoplasms.
Author:	Mima, Kosuke\|Ogino, Shuji\|Nakagawa, Shigeki\|Sawayama, Hiroshi\|Kinoshita, Koichi\|Krashima, Ryuichi\|Ishimoto, Takatsugu\|Imai, Katsunori\|Iwatsuki, Masaaki\|Hashimoto, Daisuke\|Baba, Yoshifumi\|Sakamoto, Yasuo\|Yamashita, Yo-Ichi\|Yoshida, Naoya\|Chikamoto, Akira\|I
PMID:	29113654

65.
Journal:	Nanomedicine. 2017 Nov;13(8):2671-2682.
Title:	Improved tumor accumulation and therapeutic efficacy of CTLA-4-blocking antibody using liposome-encapsulated antibody: In vitro and in vivo studies.
Author:	Nikpoor, Amin Reza\|Tavakkol-Afshari, Jalil\|Sadri, Kayvan\|Jalali, Seyed Amir\|Jaafari, Mahmoud Reza
PMID:	28847682

66.
Journal:	Sci Immunol. 2017 May 19;2(11). pii: 2/11/eaaj1738.
Title:	Targeting latency-associated peptide promotes antitumor immunity.
Author:	Gabriely, Galina\|da Cunha, Andre P\|Rezende, Rafael M\|Kenyon, Brendan\|Madi, Asaf\|Vandeventer, Tyler\|Skillin, Nathaniel\|Rubino, Stephen\|Garo, Lucien\|Mazzola, Maria A\|Kolypetri, Panagiota\|Lanser, Amanda J\|Moreira, Thais\|Faria, Ana Maria C\|Lassmann, Hans\|Kuch
PMID:	28763794

67.
Journal:	Int J Mol Sci. 2017 Jun 21;18(6). pii: ijms18061324.
Title:	Immune Checkpoints as a Target for Colorectal Cancer Treatment.
Author:	Passardi, Alessandro\|Canale, Matteo\|Valgiusti, Martina\|Ulivi, Paola
PMID:	28635639

68.
Journal:	Immunol Invest. 2017 Apr;46(3):221-238.
Title:	Immunomodulating and Immunoresistance Properties of Cancer-Initiating Cells: Implications for the Clinical Success of Immunotherapy.
Author:	Maccalli, Cristina\|Parmiani, Giorgio\|Ferrone, Soldano
PMID:	28287848

69.
Journal:	World J Gastroenterol. 2017 Jan 21;23(3):455-463.
Title:	Role of LAP(+)CD4(+) T cells in the tumor microenvironment of colorectal cancer.
Author:	Zhong, Wu\|Jiang, Zhi-Yuan\|Zhang, Lei\|Huang, Jia-Hao\|Wang, Shi-Jun\|Liao, Cun\|Cai, Bin\|Chen, Li-Sheng\|Zhang, Sen\|Guo, Yun\|Cao, Yun-Fei\|Gao, Feng
PMID:	28210081

70.
Journal:	Cancer Gene Ther. 2017 Feb;24(2):57-63.
Title:	Tumor-associated immune factors are associated with recurrence and metastasis in non-small cell lung cancer.
Author:	Yan, X\|Jiao, S-C\|Zhang, G-Q\|Guan, Y\|Wang, J-L
PMID:	28084319

71.
Journal:	Oncotarget. 2017 Feb 7;8(6):9155-9173.
Title:	Neuroinflammatory and cognitive consequences of combined radiation and immunotherapy in a novel preclinical model.
Author:	McGinnis, Gwendolyn J\|Friedman, David\|Young, Kristina H\|Torres, Eileen Ruth S\|Thomas, Charles R Jr\|Gough, Michael J\|Raber, Jacob
PMID:	27893434

72.
Journal:	Front Immunol. 2017 May 26;8:619.
Title:	Intratumoral FoxP3(+)Helios(+) Regulatory T Cells Upregulating Immunosuppressive Molecules Are Expanded in Human Colorectal Cancer.
Author:	Syed Khaja, Azharuddin Sajid\|Toor, Salman M\|El Salhat, Haytham\|Ali, Bassam R\|Elkord, Eyad
PMID:	28603527

73.
Journal:	Cancer Immunol Immunother. 2018 Oct 12. pii: 10.1007/s00262-018-2259-0.
Title:	Association of IL-36gamma with tertiary lymphoid structures and inflammatory immune infiltrates in human colorectal cancer.
Author:	Weinstein, Aliyah M\|Giraldo, Nicolas A\|Petitprez, Florent\|Julie, Catherine\|Lacroix, Laetitia\|Peschaud, Frederique\|Emile, Jean-Francois\|Marisa, Laetitia\|Fridman, Wolf H\|Storkus, Walter J\|Sautes-Fridman, Catherine
PMID:	30315348

74.
Journal:	Semin Radiat Oncol. 2018 Oct;28(4):288-294.
Title:	A Contemporary Update on the Role of Stereotactic Body Radiation Therapy (SBRT) for Liver Metastases in the Evolving Landscape of Oligometastatic Disease Management.
Author:	Robin, Tyler P\|Raben, David\|Schefter, Tracey E
PMID:	30309639

75.
Journal:	Cancer Manag Res. 2018 Sep 17;10:3569-3577.
Title:	Low tumor purity is associated with poor prognosis, heavy mutation burden, and intense immune phenotype in colon cancer.
Author:	Mao, Yihao\|Feng, Qingyang\|Zheng, Peng\|Yang, Liangliang\|Liu, Tianyu\|Xu, Yuqiu\|Zhu, Dexiang\|Chang, Wenju\|Ji, Meiling\|Ren, Li\|Wei, Ye\|He, Guodong\|Xu, Jianmin
PMID:	30271205

76.
Journal:	Onco Targets Ther. 2018 Aug 7;11:4609-4619.
Title:	CTLA4 tagging polymorphisms and risk of colorectal cancer: a case-control study involving 2,306 subjects.
Author:	Zou, Chen\|Qiu, Hao\|Tang, Weifeng\|Wang, Yafeng\|Lan, Bin\|Chen, Yu
PMID:	30122952

77.
Journal:	Clin Epigenetics. 2018 Aug 6;10(1):104.
Title:	DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer.
Author:	Sasidharan Nair, Varun\|Toor, Salman M\|Taha, Rowaida Z\|Shaath, Hibah\|Elkord, Eyad
PMID:	30081950

78.
Journal:	Cancer Immunol Res. 2018 Sep;6(9):1082-1092.
Title:	RORgammat-Expressing Tregs Drive the Growth of Colitis-Associated Colorectal Cancer by Controlling IL6 in Dendritic Cells.
Author:	Rizzo, Angelamaria\|Di Giovangiulio, Martina\|Stolfi, Carmine\|Franze, Eleonora\|Fehling, Hans-Joerg\|Carsetti, Rita\|Giorda, Ezio\|Colantoni, Alfredo\|Ortenzi, Angela\|Rugge, Massimo\|Mescoli, Claudia\|Monteleone, Giovanni\|Fantini, Massimo C
PMID:	29991500

79.
Journal:	J Cancer Res Ther. 2018 Jun;14(Supplement):S526-S532.
Title:	Association of cytotoxic T-lymphocyte antigen 4 rs231775 gene polymorphism with colorectal cancer risk.
Author:	Zhang, Yanli\|Zhang, Suiliang\|Xia, Wei\|Dong, Zhiyong
PMID:	29970719

80.
Journal:	Nat Immunol. 2018 Jun 18. pii: 10.1038/s41590-018-0132-0.
Title:	Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity.
Author:	Zhang, Qing\|Bi, Jiacheng\|Zheng, Xiaodong\|Chen, Yongyan\|Wang, Hua\|Wu, Wenyong\|Wang, Zhengguang\|Wu, Qiang\|Peng, Hui\|Wei, Haiming\|Sun, Rui\|Tian, Zhigang
PMID:	29915296

81.
Journal:	Oncoimmunology. 2018 Apr 25;7(7):e1448332.
Title:	Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer.
Author:	Zhou, Guoying\|Noordam, Lisanne\|Sprengers, Dave\|Doukas, Michail\|Boor, Patrick P C\|van Beek, Adriaan A\|Erkens, Remco\|Mancham, Shanta\|Grunhagen, Dirk\|Menon, Anand G\|Lange, Johan F\|Burger, Pim J W A\|Brandt, Alexandra\|Galjart, Boris\|Verhoef, Cornelis\|Kwekkeboo
PMID:	29900067

82.
Journal:	Curr Protein Pept Sci. 2018;19(11):1107-1113.
Title:	ICOS-L as a Potential Therapeutic Target for Cancer Immunotherapy.
Author:	Marinelli, Oliviero\|Nabissi, Massimo\|Morelli, Maria Beatrice\|Torquati, Luciana\|Amantini, Consuelo\|Santoni, Giorgio
PMID:	29879883

83.
Journal:	Oncoimmunology. 2018 Feb 14;7(6):e1431088.
Title:	RANKL blockade improves efficacy of PD1-PD-L1 blockade or dual PD1-PD-L1 and CTLA4 blockade in mouse models of cancer.
Author:	Ahern, Elizabeth\|Harjunpaa, Heidi\|O'Donnell, Jake S\|Allen, Stacey\|Dougall, William C\|Teng, Michele W L\|Smyth, Mark J
PMID:	29872559

84.
Journal:	Ann Surg Treat Res. 2018 Jun;94(6):312-321.
Title:	Diagnostic value of peripheral blood immune profiling in colorectal cancer.
Author:	Choi, Joungbum\|Maeng, Hyung Gun\|Lee, Su Jin\|Kim, Young Joo\|Kim, Da Woon\|Lee, Ha Na\|Namgung, Ji Hyeon\|Oh, Hyun-Mee\|Kim, Tae Joo\|Jeong, Ji Eun\|Park, Sang Jean\|Choi, Yong Man\|Kang, Yong Won\|Yoon, Seo Gue\|Lee, Jong Kyun
PMID:	29854709

85.
Journal:	Int J Mol Med. 2018 Aug;42(2):713-725.
Title:	Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review).
Author:	Katoh, Masaru
PMID:	29786110

86.
Journal:	Ann Surg Oncol. 2018 Aug;25(8):2323-2331.
Title:	Cytolytic Activity Score to Assess Anticancer Immunity in Colorectal Cancer.
Author:	Narayanan, Sumana\|Kawaguchi, Tsutomu\|Yan, Li\|Peng, Xuan\|Qi, Qianya\|Takabe, Kazuaki
PMID:	29770915

87.
Journal:	JAMA Oncol. 2018 Aug 1;4(8):1085-1092.
Title:	Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome.
Author:	Chang, Kyle\|Taggart, Melissa W\|Reyes-Uribe, Laura\|Borras, Ester\|Riquelme, Erick\|Barnett, Reagan M\|Leoni, Guido\|San Lucas, F Anthony\|Catanese, Maria T\|Mori, Federica\|Diodoro, Maria G\|You, Y Nancy\|Hawk, Ernest T\|Roszik, Jason\|Scheet, Paul\|Kopetz, Scott\|Nico
PMID:	29710228

88.
Journal:	Oncol Res Treat. 2018;41(5):282-285.
Title:	Immunotherapy of Colon Cancer.
Author:	Stein, Alexander\|Folprecht, Gunnar
PMID:	29705788

89.
Journal:	J Clin Invest. 2018 May 1;128(5):2104-2115.
Title:	Increased vessel perfusion predicts the efficacy of immune checkpoint blockade.
Author:	Zheng, Xichen\|Fang, Zhaoxu\|Liu, Xiaomei\|Deng, Shengming\|Zhou, Pei\|Wang, Xuexiang\|Zhang, Chenglin\|Yin, Rongping\|Hu, Haitian\|Chen, Xiaolan\|Han, Yijie\|Zhao, Yun\|Lin, Steven H\|Qin, Songbing\|Wang, Xiaohua\|Kim, Betty Ys\|Zhou, Penghui\|Jiang, Wen\|Wu, Qingyu\|Huang
PMID:	29664018

90.
Journal:	Future Oncol. 2018 Apr;14(10):947-962.
Title:	Upper gastrointestinal malignancies in 2017: current perspectives and future approaches.
Author:	Solomon, Benjamin L\|Garrido-Laguna, Ignacio
PMID:	29542354

91.
Journal:	J Cancer Res Clin Oncol. 2018 Jun;144(6):1005-1014.
Title:	CD274, LAG3, and IDO1 expressions in tumor-infiltrating immune cells as prognostic biomarker for patients with MSI-high colon cancer.
Author:	Lee, Soo Jung\|Jun, Sun-Young\|Lee, In Hee\|Kang, Byung Woog\|Park, Su Yeon\|Kim, Hye Jin\|Park, Jun Seok\|Choi, Gyu-Seog\|Yoon, Ghilsuk\|Kim, Jong Gwang
PMID:	29520442

92.
Journal:	Gut. 2018 Jun;67(6):1168-1180.
Title:	Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine.
Author:	Ogino, Shuji\|Nowak, Jonathan A\|Hamada, Tsuyoshi\|Phipps, Amanda I\|Peters, Ulrike\|Milner, Danny A Jr\|Giovannucci, Edward L\|Nishihara, Reiko\|Giannakis, Marios\|Garrett, Wendy S\|Song, Mingyang
PMID:	29437869

93.
Journal:	Cancer Treat Rev. 2018 Feb;63:48-60.
Title:	Rationale for combination of therapeutic antibodies targeting tumor cells and immune checkpoint receptors: Harnessing innate and adaptive immunity through IgG1 isotype immune effector stimulation.
Author:	Ferris, Robert L\|Lenz, Heinz-Josef\|Trotta, Anna Maria\|Garcia-Foncillas, Jesus\|Schulten, Jeltje\|Audhuy, Francois\|Merlano, Marco\|Milano, Gerard
PMID:	29223828

94.
Journal:	Cancer Immunol Res. 2018 Jan;6(1):59-68.
Title:	Soluble CD80 Protein Delays Tumor Growth and Promotes Tumor-Infiltrating Lymphocytes.
Author:	Horn, Lucas A\|Long, Tiha M\|Atkinson, Ryan\|Clements, Virginia\|Ostrand-Rosenberg, Suzanne
PMID:	29122838

95.
Journal:	Arch Pathol Lab Med. 2018 Jan;142(1):26-34.
Title:	Is There a Role for Programmed Death Ligand-1 Testing and Immunotherapy in Colorectal Cancer With Microsatellite Instability? Part II-The Challenge of Programmed Death Ligand-1 Testing and Its Role in Microsatellite Instability-High Colorectal Cancer.
Author:	Marginean, Esmeralda Celia\|Melosky, Barbara
PMID:	29120224