Primary Site >> Stomach Cancer

Gene >> CDKN2B

Journal: Jpn J Cancer Res. 1996 Oct;87(10):1052-5.
Title: Intragenic homozygous deletions of MTS1 gene in gastric cancer in Taiwan.
Author: Wu, M S|Lin, Y W|Sheu, J C|Wang, H P|Wang, J T|Shun, C T|Lee, W J|Wang, T H|Lin, J T
PMID: 8957063
Journal: Jpn J Cancer Res. 1996 Aug;87(8):824-30.
Title: Genetic status and expression of the cyclin-dependent kinase inhibitors in human gastric carcinoma cell lines.
Author: Akama, Y|Yasui, W|Kuniyasu, H|Yokozaki, H|Akagi, M|Tahara, H|Ishikawa, T|Tahara, E
PMID: 8797888
Journal: Cancer. 1997 Nov 15;80(10):1889-96.
Title: Alterations of p16INK4A and p15INK4B genes in gastric carcinomas.
Author: Lee, Y Y|Kang, S H|Seo, J Y|Jung, C W|Lee, K U|Choe, K J|Kim, B K|Kim, N K|Koeffler, H P|Bang, Y J
PMID: 9366289
Journal: Gan To Kagaku Ryoho. 1997 Jul;24 Suppl 2:279-84.
Title: [Alteration of p15 and p16 gene in gastric cancer].
Author: Fushida, S|Yonemura, Y|Kawamura, T|Nojima, N|Satoh, T|Fujita, H|Michiwa, Y|Fujimura, T|Nishimura, G|Miwa, K|Miyazaki, I
PMID: 9263516
Journal: J Gastroenterol Hepatol. 1998 Mar;13(3):305-10.
Title: Overexpression of mutant p53 and c-erbB-2 proteins and mutations of the p15 and p16 genes in human gastric carcinoma: with respect to histological subtypes and stages.
Author: Wu, M S|Shun, C T|Sheu, J C|Wang, H P|Wang, J T|Lee, W J|Chen, C J|Wang, T H|Lin, J T
PMID: 9570245
Journal: Cancer Res. 1999 Feb 1;59(3):748-52.
Title: Comparative genomic hybridization of cancer of the gastroesophageal junction: deletion of 14Q31-32.1 discriminates between esophageal (Barrett's) and gastric cardia adenocarcinomas.
Author: van Dekken, H|Geelen, E|Dinjens, W N|Wijnhoven, B P|Tilanus, H W|Tanke, H J|Rosenberg, C
PMID: 9973227
Journal: Annu Rev Med. 1999;50:401-23.
Title: The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer.
Author: Tsihlias, J|Kapusta, L|Slingerland, J
PMID: 10073286
Journal: Br J Cancer. 1999 Jun;80(8):1144-9.
Title: Rapid induction of p21WAF1 but delayed down-regulation of Cdc25A in the TGF-beta-induced cell cycle arrest of gastric carcinoma cells.
Author: Kang, S H|Bang, Y J|Jong, H S|Seo, J Y|Kim, N K|Kim, S J
PMID: 10376964
Journal: Cancer. 2001 Jun 15;91(12):2294-301.
Title: Concurrent hypermethylation of multiple tumor-related genes in gastric carcinoma and adjacent normal tissues.
Author: Leung, W K|Yu, J|Ng, E K|To, K F|Ma, P K|Lee, T L|Go, M Y|Chung, S C|Sung, J J
PMID: 11413518
Journal: Clin Cancer Res. 2002 Jun;8(6):1761-6.
Title: Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma.
Author: Lee, Tin-Lap|Leung, Wai K|Chan, Michael W Y|Ng, Enders K W|Tong, Joanna H M|Lo, Kwok-Wai|Chung, S C Sydney|Sung, Joseph J Y|To, Ka-Fai
PMID: 12060614
Journal: Int J Cancer. 2002 Dec 20;102(6):623-8.
Title: Promoter hypermethylation of tumor-related genes in gastric intestinal metaplasia of patients with and without gastric cancer.
Author: To, Ka-Fai|Leung, Wai K|Lee, Tin-Lap|Yu, Jun|Tong, Joanna H M|Chan, Michael W Y|Ng, Enders K W|Chung, S C Sydney|Sung, Joseph J Y
PMID: 12448005
Journal: Cancer Sci. 2003 Jan;94(1):76-80.
Title: Global and non-random CpG-island methylation in gastric carcinoma associated with Epstein-Barr virus.
Author: Chong, Ja-Mun|Sakuma, Kazuya|Sudo, Makoto|Ushiku, Tetsuo|Uozaki, Hiroshi|Shibahara, Junji|Nagai, Hideo|Funata, Nobuaki|Taniguchi, Hirokazu|Aburatani, Hiroyuki|Fukayama, Masashi
PMID: 12708478
Journal: Oncogene. 2004 Feb 19;23(7):1333-41.
Title: Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer.
Author: Han, Sang-Uk|Kim, Heung-Tae|Seong, Do Hwan|Kim, Yong-Suk|Park, Yoon-Soo|Bang, Yung-Jue|Yang, Han-Kwang|Kim, Seong-Jin
PMID: 14647420
Journal: J Biochem Biophys Methods. 2004 Aug 31;60(2):139-50.
Title: High-throughput method for detecting DNA methylation.
Author: Hou, Peng|Ji, Meiju|Li, Song|He, Nongyue|Lu, Zuhong
PMID: 15262448
Journal: Br J Cancer. 2005 Jun 20;92(12):2190-4.
Title: Potential diagnostic and prognostic values of detecting promoter hypermethylation in the serum of patients with gastric cancer.
Author: Leung, W K|To, K-F|Chu, E S H|Chan, M W Y|Bai, A H C|Ng, E K W|Chan, F K L|Sung, J J Y
PMID: 15942635
Journal: Cancer Lett. 2005 Jul 28;225(2):291-5.
Title: Non-random structural chromosomal changes in primary gastric cancer.
Author: Panani, Anna D|Roussos, Charis
PMID: 15978333
Journal: World J Gastroenterol. 2005 Jan 7;11(1):61-8.
Title: Association between endogenous gene expression and growth regulation induced by TGF-beta1 in human gastric cancer cells.
Author: Li, Xue|Zhang, Yun-Yan|Wang, Qi|Fu, Song-Bin
PMID: 15609398
Journal: Clin Cancer Res. 2006 May 15;12(10):2995-3002.
Title: CpG island methylation status in gastric carcinoma with and without infection of Epstein-Barr virus.
Author: Chang, Moon-Sung|Uozaki, Hiroshi|Chong, Ja-Mun|Ushiku, Tetsuo|Sakuma, Kazuya|Ishikawa, Shunpei|Hino, Rumi|Barua, Rita Rani|Iwasaki, Yoshiaki|Arai, Kuniyoshi|Fujii, Hideki|Nagai, Hideo|Fukayama, Masashi
PMID: 16707594
Journal: Rev Med Chil. 2007 Jan;135(1):17-25. Epub 2007 Mar 6.
Title: [Hierarchical clustering analysis to detect associations between clinical and pathological features of gastric tumors and hypermethylation of suppressor genes].
Author: Zavala G, Luis|Luengo J, Victor|Ossandon C, Francisco|Riquelme S, Erick|Backhouse E, Claudia|Palma V, Mariana|Argandona C, Jorge|Cumsille, Miguel Angel|Corvalan R, Alejandro
PMID: 17369979
Journal: Hum Pathol. 2007 Jun;38(6):903-13. Epub 2007 Mar 21.
Title: Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis.
Author: Milne, Anya N A|Sitarz, Robert|Carvalho, Ralph|Polak, Mirjam M|Ligtenberg, Marjolijn|Pauwels, Patrick|Offerhaus, G Johan A|Weterman, Marian A J
PMID: 17376510
Journal: Int J Surg Pathol. 2007 Jul;15(3):242-51.
Title: Aberrant methylation of multiple genes in gastric carcinomas.
Author: Zhao, Ying-Fang|Zhang, Yun-Gang|Tian, Xin-Xia|Juan Du|Jie Zheng
PMID: 17652530
Journal: Anticancer Res. 2008 Mar-Apr;28(2A):1079-83.
Title: Immunohistochemical expression of P15 (INK4B) and SMAD4 in advanced gastric cancer.
Author: Sakellariou, Stratigoula|Liakakos, Theodore|Ghiconti, Ioanna|Hadjikokolis, Stamatis|Nakopoulou, Lydia|Pavlakis, Kitty
PMID: 18507057
Journal: Clin Cancer Res. 2008 Oct 1;14(19):6264-9.
Title: Reprimo as a potential biomarker for early detection in gastric cancer.
Author: Bernal, Carolina|Aguayo, Francisco|Villarroel, Cynthia|Vargas, Macarena|Diaz, Ignacio|Ossandon, Francisco J|Santibanez, Eudocia|Palma, Mariana|Aravena, Edmundo|Barrientos, Carlos|Corvalan, Alejandro H
PMID: 18829507
Journal: Ann N Y Acad Sci. 2008 Aug;1137:226-31.
Title: Circulating DNA in the blood of gastric cancer patients.
Author: Kolesnikova, Elena V|Tamkovich, Svetlana N|Bryzgunova, Olga E|Shelestyuk, Petr I|Permyakova, Valentina I|Vlassov, Valentin V|Tuzikov, Aleksandr S|Laktionov, Pavel P|Rykova, Elena Y
PMID: 18837952
Journal: Biol Res. 2008;41(3):303-15.
Title: DNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA1 promoter region in early-onset gastric carcinogenesis.
Author: Bernal, Carolina|Vargas, Macarena|Ossandon, Francisco|Santibanez, Eudocia|Urrutia, Julio|Luengo, Victor|Zavala, Luis F|Backhouse, Claudia|Palma, Mariana|Argandona, Jorge|Aguayo, Francisco|Corvalan, Alejandro
PMID: 19399343
Journal: Mol Cancer Res. 2009 Apr;7(4):570-80.
Title: RhoA regulates G1-S progression of gastric cancer cells by modulation of multiple INK4 family tumor suppressors.
Author: Zhang, Siyuan|Tang, Qiulin|Xu, Feng|Xue, Yan|Zhen, Zipeng|Deng, Yu|Liu, Ming|Chen, Ji|Liu, Surui|Qiu, Meng|Liao, Zhengyin|Li, Zhiping|Luo, Deyun|Shi, Fang|Zheng, Yi|Bi, Feng
PMID: 19372585
Journal: Gastroenterology. 2010 Dec;139(6):1984-94.
Title: Up-regulation of activation-induced cytidine deaminase causes genetic aberrations at the CDKN2b-CDKN2a in gastric cancer.
Author: Matsumoto, Yuko|Marusawa, Hiroyuki|Kinoshita, Kazuo|Niwa, Yoko|Sakai, Yoshiharu|Chiba, Tsutomu
PMID: 20637757
Journal: Int Immunopharmacol. 2011 Oct;11(10):1573-7.
Title: Arctigenin induces cell cycle arrest by blocking the phosphorylation of Rb via the modulation of cell cycle regulatory proteins in human gastric cancer cells.
Author: Jeong, Jin Boo|Hong, Se Chul|Jeong, Hyung Jin|Koo, Jin Suk
PMID: 21621647
Journal: J Exp Clin Cancer Res. 2012 Jul 24;31:61.
Title: 125I seed irradiation induces up-regulation of the genes associated with apoptosis and cell cycle arrest and inhibits growth of gastric cancer xenografts.
Author: Ma, Zhen-Huan|Yang, Yong|Zou, Lei|Luo, Kai-Yuan
PMID: 22827957
Journal: Int J Oncol. 2012 Sep;41(3):839-48.
Title: Tob1 induces apoptosis and inhibits proliferation, migration and invasion of gastric cancer cells by activating Smad4 and inhibiting betacatenin signaling.
Author: Kundu, Juthika|Wahab, S M Riajul|Kundu, Joydeb Kumar|Choi, Yoon-La|Erkin, Ozgur Cem|Lee, Hun Seok|Park, Sang Gyu|Shin, Young Kee
PMID: 22710759
Journal: Tumour Biol. 2013 Aug;34(4):2127-33.
Title: Analysis of the methylation patterns of the p16 INK4A, p15 INK4B, and APC genes in gastric adenocarcinoma patients from a Brazilian population.
Author: do Nascimento Borges, Barbara|Burbano, Rommel Mario Rodriguez|Harada, Maria Lucia
PMID: 23504555
Journal: Br J Cancer. 2013 Jun 25;108(12):2557-64.
Title: Somatostatin receptor 1, a novel EBV-associated CpG hypermethylated gene, contributes to the pathogenesis of EBV-associated gastric cancer.
Author: Zhao, J|Liang, Q|Cheung, K-F|Kang, W|Dong, Y|Lung, R W-M|Tong, J H-M|To, K-F|Sung, J J Y|Yu, J
PMID: 23722468
Journal: Tumour Biol. 2014 Oct;35(10):10051-6.
Title: Anticancer bioactive peptide (ACBP) inhibits gastric cancer cells by upregulating growth arrest and DNA damage-inducible gene 45A (GADD45A).
Author: Su, Li-Ya|Xin, Hong-Yi|Liu, Yong-Lei|Zhang, Jia-Ling|Xin, Hong-Wu|Su, Xiu-Lan
PMID: 25015188
Journal: Carcinogenesis. 2014 Dec;35(12):2698-705.
Title: Genetic polymorphisms in the 9p21 region associated with risk of multiple cancers.
Author: Li, Wen-Qing|Pfeiffer, Ruth M|Hyland, Paula L|Shi, Jianxin|Gu, Fangyi|Wang, Zhaoming|Bhattacharjee, Samsiddhi|Luo, Jun|Xiong, Xiaoqin|Yeager, Meredith|Deng, Xiang|Hu, Nan|Taylor, Philip R|Albanes, Demetrius|Caporaso, Neil E|Gapstur, Susan M|Amundadottir,
PMID: 25239644
Journal: Mol Cancer Ther. 2015 Jan;14(1):268-77.
Title: Long noncoding RNA ANRIL promotes non-small cell lung cancer cell proliferation and inhibits apoptosis by silencing KLF2 and P21 expression.
Author: Nie, Feng-qi|Sun, Ming|Yang, Jin-song|Xie, Min|Xu, Tong-peng|Xia, Rui|Liu, Yan-wen|Liu, Xiang-hua|Zhang, Er-bao|Lu, Kai-hua|Shu, Yong-qian
PMID: 25504755
Journal: Oncogene. 2015 Nov 5;34(45):5648-61.
Title: SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer.
Author: Xu, T-P|Liu, X-X|Xia, R|Yin, L|Kong, R|Chen, W-M|Huang, M-D|Shu, Y-Q
PMID: 25728677
Journal: Asian Pac J Cancer Prev. 2015;16(6):2425-30.
Title: siRNA silencing EZH2 reverses cisplatin-resistance of human non-small cell lung and gastric cancer cells.
Author: Zhou, Wen|Wang, Jian|Man, Wang-Ying|Zhang, Qing-Wei|Xu, Wen-Gui
PMID: 25824776
Journal: Mol Cancer. 2015 Apr 12;14:82.
Title: Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16.
Author: Kong, Rong|Zhang, Er-bao|Yin, Dan-dan|You, Liang-hui|Xu, Tong-peng|Chen, Wen-ming|Xia, Rui|Wan, Li|Sun, Ming|Wang, Zhao-xia|De, Wei|Zhang, Zhi-hong
PMID: 25890171
Journal: Int J Biochem Cell Biol. 2015 Aug;65:104-12.
Title: Enhancer of zeste homolog 2 depletion induces cellular senescence via histone demethylation along the INK4/ARF locus.
Author: Jie, Bai|Weilong, Chang|Ming, Cai|Fei, Xu|Xinghua, Liu|Junhua, Chen|Guobin, Wang|Kaixiong, Tao|Xiaoming, Shuai
PMID: 26004298
Journal: J Hematol Oncol. 2015 May 29;8(1):57.
Title: Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell proliferation by epigenetic silencing of KLF2.
Author: Huang, Ming-de|Chen, Wen-Ming|Qi, Fu-Zhen|Xia, Rui|Sun, Ming|Xu, Tong-Peng|Yin, Li|Zhang, Er-Bao|De, Wei|Shu, Yong-Qian
PMID: 27391317
Journal: Oncotarget. 2016 Mar 1;7(9):9773-87.
Title: Long intergenic non-coding RNA 00152 promotes tumor cell cycle progression by binding to EZH2 and repressing p15 and p21 in gastric cancer.
Author: Chen, Wen-ming|Huang, Ming-de|Sun, Dao-ping|Kong, Rong|Xu, Tong-peng|Xia, Rui|Zhang, Er-bao|Shu, Yong-qian
PMID: 26799422
Journal: Oncotarget. 2016 Apr 26;7(17):23212-26.
Title: E2F1-induced upregulation of long noncoding RNA LINC00668 predicts a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically silencing of CKIs.
Author: Zhang, Erbao|Yin, Dandan|Han, Liang|He, Xuezhi|Si, Xinxin|Chen, Wenming|Xia, Rui|Xu, Tongpeng|Gu, Dongying|De, Wei|Guo, Renhua|Xu, Zhi|Chen, Jinfei
PMID: 27036039
Journal: IUBMB Life. 2016 May;68(5):355-64.
Title: TET2 regulates LncRNA-ANRIL expression and inhibits the growth of human gastric cancer cells.
Author: Deng, Wei|Wang, Jin|Zhang, Jun|Cai, Jun|Bai, Zhigang|Zhang, Zhongtao
PMID: 27027260
Journal: Cell Death Dis. 2016 Feb 25;7:e2109.
Title: Increased expression of long noncoding RNA TUG1 predicts a poor prognosis of gastric cancer and regulates cell proliferation by epigenetically silencing of p57.
Author: Zhang, E|He, X|Yin, D|Han, L|Qiu, M|Xu, T|Xia, R|Xu, L|Yin, R|De, W
PMID: 26913601
Journal: J Nat Prod. 2016 Jan 22;79(1):38-50.
Title: Cardiac Glycosides from the Seeds of Thevetia peruviana.
Author: Tian, Dan-Mei|Cheng, Huo-Yun|Jiang, Miao-Miao|Shen, Wei-Zai|Tang, Jin-Shan|Yao, Xin-Sheng
PMID: 26714048
Journal: Tumour Biol. 2016 Feb;37(2):1983-93.
Title: Upregulated expression of long non-coding RNA LINC00982 regulates cell proliferation and its clinical relevance in patients with gastric cancer.
Author: Fei, Zheng-Hua|Yu, Xiao-Juan|Zhou, Ming|Su, Hua-Fang|Zheng, Zhen|Xie, Cong-Ying
PMID: 26334618
Journal: Oncogene. 2016 Apr 21;35(16):2133-44.
Title: Epigenetic silencing of GDF1 disrupts SMAD signaling to reinforce gastric cancer development.
Author: Yang, W|Mok, M T S|Li, M S M|Kang, W|Wang, H|Chan, A W|Chou, J-L|Chen, J|Ng, E K W|To, K-F|Yu, J|Chan, M W Y|Chan, F K L|Sung, J J Y|Cheng, A S L
PMID: 26212015
Journal: Onco Targets Ther. 2017 Mar 16;10:1613-1624.
Title: CDKL1 promotes tumor proliferation and invasion in colorectal cancer.
Author: Qin, Chunzhi|Ren, Li|Ji, Meiling|Lv, Shixu|Wei, Ye|Zhu, Dexiang|Lin, Qi|Xu, Pingping|Chang, Wenju|Xu, Jianmin
PMID: 28352193
Journal: Cell Death Dis. 2017 Jun 1;8(6):e2837.
Title: E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis.
Author: Xu, Tong-Peng|Wang, Yan-Fen|Xiong, Wei-Liang|Ma, Pei|Wang, Wen-Yu|Chen, Wen-Ming|Huang, Ming-De|Xia, Rui|Wang, Rong|Zhang, Er-Bao|Liu, Yan-Wen|De, Wei|Shu, Yong-Qian
PMID: 28569791
Journal: Genome Med. 2017 Oct 31;9(1):93.
Title: Actionable gene-based classification toward precision medicine in gastric cancer.
Author: Ichikawa, Hiroshi|Nagahashi, Masayuki|Shimada, Yoshifumi|Hanyu, Takaaki|Ishikawa, Takashi|Kameyama, Hitoshi|Kobayashi, Takashi|Sakata, Jun|Yabusaki, Hiroshi|Nakagawa, Satoru|Sato, Nobuaki|Hirata, Yuki|Kitagawa, Yuko|Tanahashi, Toshiyuki|Yoshida, Kazuhiro|
PMID: 29089060
Journal: Oncotarget. 2017 Sep 8;8(44):77783-77793.
Title: Promoter methylation of tumor-related genes as a potential biomarker using blood samples for gastric cancer detection.
Author: Wen, Jinfeng|Zheng, Tuo|Hu, Kefeng|Zhu, Chunxia|Guo, Lihua|Ye, Guoliang
PMID: 29100425
Journal: Eur Rev Med Pharmacol Sci. 2017 Oct;21(20):4613-4622.
Title: LncRNA SNHG7 promotes the proliferation and inhibits apoptosis of gastric cancer cells by repressing the P15 and P16 expression.
Author: Wang, M-W|Liu, J|Liu, Q|Xu, Q-H|Li, T-F|Jin, S|Xia, T-S
PMID: 29131253
Journal: Oncotarget. 2017 Aug 18;8(48):84153-84167.
Title: Long non-coding RNA SNHG15 inhibits P15 and KLF2 expression to promote pancreatic cancer proliferation through EZH2-mediated H3K27me3.
Author: Ma, Zhonghua|Huang, Hesuyuan|Wang, Jirong|Zhou, Yan|Pu, Fuxing|Zhao, Qinghong|Peng, Peng|Hui, Bingqing|Ji, Hao|Wang, Keming
PMID: 29137412
Journal: Biochimie. 2018 Mar;146:35-42.
Title: VDR independent induction of acid-sphingomyelinase by 1,23(OH)2 D3 in gastric cancer cells: Impact on apoptosis and cell morphology.
Author: Albi, Elisabetta|Cataldi, Samuela|Ferri, Ivana|Sidoni, Angelo|Traina, Giovanna|Fettucciari, Katia|Ambesi-Impiombato, Francesco Saverio|Lazzarini, Andrea|Curcio, Francesco|Ceccarini, Maria Rachele|Beccari, Tommaso|Codini, Michela
PMID: 29158006
Journal: Int J Cancer. 2018 Oct 15;143(8):1923-1934.
Title: Genetic features of multicentric/multifocal intramucosal gastric carcinoma.
Author: Mizuguchi, Aya|Takai, Atsushi|Shimizu, Takahiro|Matsumoto, Tomonori|Kumagai, Ken|Miyamoto, Shin'ichi|Seno, Hiroshi|Marusawa, Hiroyuki
PMID: 29717480
Journal: Onco Targets Ther. 2018 Aug 14;11:4877-4891.
Title: Prognostic value of long noncoding RNAs in gastric cancer: a meta-analysis.
Author: Gao, Song|Zhao, Zhi-Ying|Wu, Rong|Zhang, Yue|Zhang, Zhen-Yong
PMID: 30147339
Journal: J Cell Physiol. 2018 Sep 6.
Title: LncRNA SNHG17 promotes gastric cancer progression by epigenetically silencing of p15 and p57.
Author: Zhang, Guohua|Xu, Ying|Wang, Sijia|Gong, Zhigang|Zou, Chen|Zhang, Heng|Ma, Gui|Zhang, Wenbo|Jiang, Pengcheng
PMID: 30256413
Journal: Biosci Rep. 2018 Oct 24. pii: BSR20180558.
Title: The silencing of long non-coding RNA ANRIL suppresses invasion, and promotes apoptosis of retinoblastoma cells through ATM-E2F1 signaling pathway.
Author: Yang, Yang|Peng, Xiao-Wei
PMID: 30355646