Primary Site >> Esophagus Cancer

Gene >> CDH17

Journal: Gan To Kagaku Ryoho. 1993 Feb;20(3):326-31.
Title: [Metastasis related genes and malignancy in human esophageal, gastric and colorectal cancers].
Author: Tahara, E|Kuniyasu, H|Nakayama, H|Yasui, W|Yokozaki, H
PMID: 8094950
Journal: Nihon Rinsho. 1995 Jul;53(7):1602-6.
Title: [Correlation between the intercellular adhesion molecule (E-cadherin) and its associated protein (alpha-catenin) expression and metastasis in human digestive cancers].
Author: Shiozaki, H|Gofuku, J|Inoue, M|Tamura, S
PMID: 7629995
Journal: Hum Cell. 1996 Mar;9(1):31-6.
Title: [Mechanism of the lymph node metastasis in human esophageal cancer (epidermal growth factor causes the dysfunction of cadherin-mediated cell-cell adhesion)].
Author: Shiozaki, H
PMID: 9183627
Journal: Am J Pathol. 1996 Jan;148(1):39-46.
Title: Beta-catenin expression in human cancers.
Author: Takayama, T|Shiozaki, H|Shibamoto, S|Oka, H|Kimura, Y|Tamura, S|Inoue, M|Monden, T|Ito, F|Monden, M
PMID: 8546224
Journal: Oncology. 1997 Mar-Apr;54(2):158-65.
Title: Expression of E-cadherin, alpha-catenin, beta-catenin and plakoglobin in esophageal carcinomas and its prognostic significance: immunohistochemical analysis of 96 lesions.
Author: Nakanishi, Y|Ochiai, A|Akimoto, S|Kato, H|Watanabe, H|Tachimori, Y|Yamamoto, S|Hirohashi, S
PMID: 9075789
Journal: Genomics. 1998 Nov 15;54(1):149-54.
Title: Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin.
Author: Zhang, J S|Nelson, M|Wang, L|Liu, W|Qian, C P|Shridhar, V|Urrutia, R|Smith, D I
PMID: 9806841
Journal: Int J Oncol. 1999 Jan;14(1):33-40.
Title: Altered localization of E-cadherin and alpha-catenin in rat esophageal tumors.
Author: Khare, L|Sabourin, C L|De Young, B R|Jamasbi, R J|Stoner, G D
PMID: 9863006
Journal: Int J Cancer. 1999 Apr 20;84(2):174-8.
Title: Cytoplasmic beta-catenin in esophageal cancers.
Author: Kimura, Y|Shiozaki, H|Doki, Y|Yamamoto, M|Utsunomiya, T|Kawanishi, K|Fukuchi, N|Inoue, M|Tsujinaka, T|Monden, M
PMID: 10096251
Journal: Clin Cancer Res. 2001 Sep;7(9):2765-9.
Title: Frequent hypermethylation of the 5' CpG island of E-cadherin in esophageal adenocarcinoma.
Author: Corn, P G|Heath, E I|Heitmiller, R|Fogt, F|Forastiere, A A|Herman, J G|Wu, T T
PMID: 11555590
Journal: Hepatogastroenterology. 2004 May-Jun;51(57):736-40.
Title: Prognostic factors in esophageal cancer.
Author: Kunisaki, Chikara|Shimada, Hiroshi|Akiyama, Hirotoshi|Nomura, Masato|Matsuda, Goro|Ono, Hidetaka
PMID: 15143904
Journal: World J Gastroenterol. 2004 Nov 15;10(22):3235-9.
Title: Prognostic and clinicopathological features of E-cadherin, alpha-catenin, beta-catenin, gamma-catenin and cyclin D1 expression in human esophageal squamous cell carcinoma.
Author: Lin, Ying-Cheng|Wu, Ming-Yao|Li, De-Rui|Wu, Xian-Ying|Zheng, Rui-Ming
PMID: 15484291
Journal: Carcinogenesis. 2006 Nov;27(11):2180-9.
Title: A novel anticancer effect of garlic derivatives: inhibition of cancer cell invasion through restoration of E-cadherin expression.
Author: Chu, Qingjun|Ling, Ming-Tat|Feng, Huichen|Cheung, Hiu Wing|Tsao, Sai Wah|Wang, Xianghong|Wong, Yong Chuan
PMID: 16675472
Journal: Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):5936-43.
Title: Met receptor signaling: a key effector in esophageal adenocarcinoma.
Author: Anderson, Mark R|Harrison, Rebecca|Atherfold, Paul A|Campbell, Moray J|Darnton, S Jane|Obszynska, Jolanta|Jankowski, Janusz A Z
PMID: 17062664
Journal: Am J Epidemiol. 2008 Jan 1;167(1):7-14.
Title: The E-cadherin gene polymorphism 160C->A and cancer risk: A HuGE review and meta-analysis of 26 case-control studies.
Author: Wang, Gui-Ying|Lu, Chen-Qi|Zhang, Rong-Mei|Hu, Xiao-Hua|Luo, Z W
PMID: 17971340
Journal: Anticancer Res. 2008 Jul-Aug;28(4B):2161-7.
Title: Aberrant methylation of p16, DLEC1, BLU and E-cadherin gene promoters in nasopharyngeal carcinoma biopsies from Tunisian patients.
Author: Ayadi, Wajdi|Karray-Hakim, Hela|Khabir, Abdelmajid|Feki, Lamia|Charfi, Slim|Boudawara, Tahia|Ghorbel, Abdelmonem|Daoud, Jamel|Frikha, Mounir|Busson, Pierre|Hammami, Adnane
PMID: 18751390
Journal: Cancer Sci. 2008 Dec;99(12):2428-34.
Title: Inhibition of alpha-mannosidase Man2c1 gene expression suppresses growth of esophageal carcinoma cells through mitotic arrest and apoptosis.
Author: Tian, Yun|Ju, Ji Yu|Zhou, Yi Qun|Liu, Yin|Zhu, Li Ping
PMID: 19018777
Journal: J Thorac Cardiovasc Surg. 2010 May;139(5):1224-32, 1232.e1.
Title: Combined proteasome and histone deacetylase inhibition attenuates epithelial-mesenchymal transition through E-cadherin in esophageal cancer cells.
Author: Taylor, Matthew D|Liu, Yuan|Nagji, Alykhan S|Theodosakis, Nicholas|Jones, David R
PMID: 20412959
Journal: Virchows Arch. 2010 Nov;457(5):537-45.
Title: Comparison of six immunohistochemical markers for the histologic diagnosis of neoplasia in Barrett's esophagus.
Author: Weimann, Andreas|Rieger, Anja|Zimmermann, Mathias|Gross, Monica|Hoffmann, Peter|Slevogt, Hortense|Morawietz, Lars
PMID: 20844891
Journal: Neoplasia. 2010 Jun;12(6):485-98.
Title: Cathepsin B is the driving force of esophageal cell invasion in a fibroblast-dependent manner.
Author: Andl, Claudia D|McCowan, Kelsey M|Allison, Gillian L|Rustgi, Anil K
PMID: 20563251
Journal: PLoS One. 2011;6(11):e27063.
Title: CD44 upregulation in E-cadherin-negative esophageal cancers results in cell invasion.
Author: Le Bras, Gregoire F|Allison, Gillian L|Richards, Nicole F|Ansari, Shazia S|Washington, M Kay|Andl, Claudia D
PMID: 22069487
Journal: Zhonghua Yi Xue Za Zhi. 2011 Oct 11;91(37):2653-6.
Title: [Aberrant methylation of T-cadherin gene in human esophageal carcinoma cells].
Author: Jing, Zhao|Zou, Chang-lin|Li, Gang|Deng, Xia|Wu, Shi-xiu
PMID: 22321935
Journal: World J Gastroenterol. 2012 Mar 7;18(9):915-22.
Title: S100A4 silencing blocks invasive ability of esophageal squamous cell carcinoma cells.
Author: Chen, Dong|Zheng, Xue-Feng|Yang, Ze-You|Liu, Dong-Xiao|Zhang, Guo-You|Jiao, Xue-Long|Zhao, Hui
PMID: 22408350
Journal: Mol Cancer Res. 2012 Aug;10(8):1032-8.
Title: Protein kinase casein kinase 2-mediated upregulation of N-cadherin confers anoikis resistance on esophageal carcinoma cells.
Author: Ko, Hyeonseok|Kim, Seongrak|Jin, Cheng-Hao|Lee, Eunjung|Ham, Sunyoung|Yook, Jong In|Kim, Kunhong
PMID: 22767590
Journal: Dis Esophagus. 2013 Jan;26(1):75-83.
Title: Hypoxia suppresses E-cadherin and enhances matrix metalloproteinase-2 expression favoring esophageal carcinoma migration and invasion via hypoxia inducible factor-1 alpha activation.
Author: Jing, S-w|Wang, Y-d|Chen, L-Q|Sang, M-x|Zheng, M-m|Sun, G-g|Liu, Q|Cheng, Y-j|Yang, C-r
PMID: 22340517
Journal: BMC Cell Biol. 2013 Sep 27;14:44.
Title: Physiological beta-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma.
Author: Cheng, Yue|Cheung, Arthur Kwok Leung|Ko, Josephine Mun Yee|Phoon, Yee Peng|Chiu, Pui Man|Lo, Paulisally Hau Yi|Waterman, Marian L|Lung, Maria Li
PMID: 24073846
Journal: Int J Clin Exp Pathol. 2014 Sep 15;7(10):6943-9. eCollection 2014.
Title: Epithelial-to-mesenchymal transition in human esophageal cancer associates with tumor progression and patient's survival.
Author: Liu, Jian|Chen, Lujun|Deng, Haifeng|Xu, Bin|Li, Min|Zheng, Xiao|Wu, Changping|Jiang, Jingting
PMID: 25400779
Journal: Oncotarget. 2014 Nov 30;5(22):11669-80.
Title: MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma.
Author: Song, Ye|Li, Jiangchao|Zhu, Yinghui|Dai, Yongdong|Zeng, Tingting|Liu, Lulu|Li, Jianbiao|Wang, Hongbo|Qin, Yanru|Zeng, Musheng|Guan, Xin-Yuan|Li, Yan
PMID: 25375090
Journal: Carcinogenesis. 2014 Nov;35(11):2602-10.
Title: Concerted loss of TGFbeta-mediated proliferation control and E-cadherin disrupts epithelial homeostasis and causes oral squamous cell carcinoma.
Author: Andl, Thomas|Le Bras, Gregoire F|Richards, Nicole F|Allison, Gillian L|Loomans, Holli A|Washington, M Kay|Revetta, Frank|Lee, Rebecca K|Taylor, Chase|Moses, Harold L|Andl, Claudia D
PMID: 25233932
Journal: Asian Pac J Cancer Prev. 2014;15(11):4539-43.
Title: Aberrant epigenetic alteration in Eca9706 cells modulated by nanoliposomal quercetin combined with butyrate mediated via epigenetic-NF-kappaB signaling.
Author: Zheng, Nai-Gang|Wang, Jun-Ling|Yang, Sheng-Li|Wu, Jing-Lan
PMID: 24969881
Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jun;34(6):798-801.
Title: [Amphotericin B suppresses migration and invasion of esophageal carcinoma Eca109 cells in hypoxic microenvironment by down-regulating hypoxia-inducible factor-1alpha activity].
Author: Kang, Qiangqiang|Tang, Min|Hou, Yanli|Duan, Liqun|Chen, Xingyue|Shu, Jin|Wu, Furong|Wang, Ying|Li, Shaolin
PMID: 24968833
Journal: Mol Cancer. 2014 Apr 1;13:76.
Title: F-box protein complex FBXL19 regulates TGFbeta1-induced E-cadherin down-regulation by mediating Rac3 ubiquitination and degradation.
Author: Dong, Su|Zhao, Jing|Wei, Jianxin|Bowser, Rachel K|Khoo, Andrew|Liu, Zhonghui|Luketich, James D|Pennathur, Arjun|Ma, Haichun|Zhao, Yutong
PMID: 24684802
Journal: Int J Oncol. 2014 Mar;44(3):812-8.
Title: Metastasis-associated protein 1 promotes tumor invasion by downregulation of E-cadherin.
Author: Weng, Wenhao|Yin, Jiayi|Zhang, Yue|Qiu, Jin|Wang, Xinghe
PMID: 24424621
Journal: Dis Esophagus. 2014 Sep-Oct;27(7):685-92.
Title: Blockage of Nrf2 suppresses the migration and invasion of esophageal squamous cell carcinoma cells in hypoxic microenvironment.
Author: Shen, H|Yang, Y|Xia, S|Rao, B|Zhang, J|Wang, J
PMID: 24028437
Journal: Tumour Biol. 2014 Feb;35(2):1193-201.
Title: Notch-1-mediated esophageal carcinoma EC-9706 cell invasion and metastasis by inducing epithelial-mesenchymal transition through Snail.
Author: Wang, Tao|Xuan, Xiaoyan|Pian, Linping|Gao, Ping|Hu, Hong|Zheng, Yuling|Zang, Wenqiao|Zhao, Guoqiang
PMID: 24022665
Journal: World J Gastroenterol. 2014 May 21;20(19):5839-48.
Title: Down-regulated gamma-catenin expression is associated with tumor aggressiveness in esophageal cancer.
Author: Fang, Wang-Kai|Liao, Lian-Di|Gu, Wei|Chen, Bo|Wu, Zhi-Yong|Wu, Jian-Yi|Shen, Jian|Xu, Li-Yan|Li, En-Min
PMID: 24914344
Journal: Drug Des Devel Ther. 2015 Feb 17;9:993-1026.
Title: Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells.
Author: Wang, Yan-Yang|Yang, Yin-Xue|Zhao, Ren|Pan, Shu-Ting|Zhe, Hong|He, Zhi-Xu|Duan, Wei|Zhang, Xueji|Yang, Tianxin|Qiu, Jia-Xuan|Zhou, Shu-Feng
PMID: 25733817
Journal: Yi Chuan. 2015 Apr;37(4):360-6.
Title: [IGHMBP2 overexpression promotes cell migration and invasion in esophageal squamous carcinoma].
Author: Chunli, Wang|Jiajie, Hao|Lifei, Wu|Beiqing, Pan|Xin, Xu|Yan, Cai|Mingrong, Wang|Xuemei, Jia
PMID: 25881701
Journal: J Transl Med. 2015 Mar 31;13:104.
Title: FH535 increases the radiosensitivity and reverses epithelial-to-mesenchymal transition of radioresistant esophageal cancer cell line KYSE-150R.
Author: Su, Huafang|Jin, Xiance|Zhang, Xuebang|Zhao, Lihao|Lin, Baochai|Li, Lili|Fei, Zhenghua|Shen, Lanxiao|Fang, Ya|Pan, Huanle|Xie, Congying
PMID: 25888911
Journal: Am J Transl Res. 2015 Aug 15;7(8):1390-403. eCollection 2015.
Title: MiR-133a suppresses the migration and invasion of esophageal cancer cells by targeting the EMT regulator SOX4.
Author: Li, Shujun|Qin, Xuebo|Li, Yang|Zhang, Xun|Niu, Ren|Zhang, Helin|Cui, Airong|An, Wenting|Wang, Xiaolu
PMID: 26396670
Journal: Cancer Biol Ther. 2016 Sep;17(9):943-54.
Title: NDRG1 overexpression promotes the progression of esophageal squamous cell carcinoma through modulating Wnt signaling pathway.
Author: Ai, Runna|Sun, Yulin|Guo, Zhimin|Wei, Wei|Zhou, Lanping|Liu, Fang|Hendricks, Denver T|Xu, Yang|Zhao, Xiaohang
PMID: 27414086
Journal: Sci Rep. 2016 Dec 2;6:38221.
Title: Dynamic Microenvironment Induces Phenotypic Plasticity of Esophageal Cancer Cells Under Flow.
Author: Calibasi Kocal, Gizem|Guven, Sinan|Foygel, Kira|Goldman, Aaron|Chen, Pu|Sengupta, Shiladitya|Paulmurugan, Ramasamy|Baskin, Yasemin|Demirci, Utkan
PMID: 27910892
Journal: Int J Oncol. 2016 Nov;49(5):1859-1869.
Title: Valproic acid inhibits irradiation-induced epithelial-mesenchymal transition and stem cell-like characteristics in esophageal squamous cell carcinoma.
Author: Kanamoto, Ayako|Ninomiya, Itasu|Harada, Shinichi|Tsukada, Tomoya|Okamoto, Koichi|Nakanuma, Shinichi|Sakai, Seisho|Makino, Isamu|Kinoshita, Jun|Hayashi, Hironori|Oyama, Katsunobu|Miyashita, Tomoharu|Tajima, Hidehiro|Takamura, Hiroyuki|Fushida, Sachio|Ohta,
PMID: 27826618
Journal: Oncol Lett. 2016 Sep;12(3):1642-1648. Epub 2016 Jul 8.
Title: ATF3 suppresses ESCC via downregulation of ID1.
Author: Li, Jian|Yang, Zishan|Chen, Zhiuguo|Bao, Yonghua|Zhang, Huijuan|Fang, Xinhui|Yang, Wancai
PMID: 27602100
Journal: World J Surg Oncol. 2016 Sep 6;14(1):240.
Title: Decreased expression of CDH1 or CTNNB1 affects poor prognosis of patients with esophageal cancer.
Author: Ishiguro, Hideyuki|Wakasugi, Takehiro|Terashita, Yukio|Sakamoto, Nobuhiro|Tanaka, Tatsuya|Mizoguchi, Koji|Sagawa, Hiroyuki|Okubo, Tomotaka|Takeyama, Hiromitsu
PMID: 27600761
Journal: Exp Ther Med. 2016 Sep;12(3):1525-1530.
Title: Inhibitory effect of alpha-solanine on esophageal carcinoma in vitro.
Author: Wang, Lei|Sun, Qian-Qian|Zhang, Shi-Jie|Du, Yu-Wen|Wang, Yuan-Yuan|Zang, Wen-Qiao|Chen, Xiao-Nan|Zhao, Guo-Qiang
PMID: 27588073
Journal: Int J Oncol. 2016 Oct;49(4):1351-9.
Title: Iron depletion-induced downregulation of N-cadherin expression inhibits invasive malignant phenotypes in human esophageal cancer.
Author: Nishitani, Seishi|Noma, Kazuhiro|Ohara, Toshiaki|Tomono, Yasuko|Watanabe, Shinichiro|Tazawa, Hiroshi|Shirakawa, Yasuhiro|Fujiwara, Toshiyoshi
PMID: 27499208
Journal: Aging (Albany NY). 2016 Jun;8(6):1236-49.
Title: Overexpressed HDAC4 is associated with poor survival and promotes tumor progression in esophageal carcinoma.
Author: Zeng, Li-Si|Yang, Xian-Zi|Wen, Yue-Feng|Mail, Shi-Juan|Wang, Meng-He|Zhang, Mei-Yin|Zheng, X F Steven|Wang, Hui-Yun
PMID: 27295551
Journal: Sci Rep. 2016 Feb 22;6:21713.
Title: Modulation of E-cadherin expression promotes migration ability of esophageal cancer cells.
Author: Li, Shujun|Qin, Xuebo|Chai, Song|Qu, Changbao|Wang, Xiaolu|Zhang, Helin
PMID: 26898709
Journal: Mol Med Rep. 2016 Feb;13(2):1097-104.
Title: Heterophyllin B inhibits the adhesion and invasion of ECA-109 human esophageal carcinoma cells by targeting PI3K/AKT/beta-catenin signaling.
Author: Tantai, Ji-Cheng|Zhang, Yao|Zhao, Heng
PMID: 26647768
Journal: J Cell Commun Signal. 2016 Mar;10(1):41-7.
Title: Subcellular localization of EGFR in esophageal carcinoma cell lines.
Author: Spohn, Lucas|Fichter, Christiane|Werner, Martin|Lassmann, Silke
PMID: 26582583
Journal: Tumour Biol. 2016 Apr;37(4):5355-63.
Title: Inhibition of cyclin D1 enhances sensitivity to radiotherapy and reverses epithelial to mesenchymal transition for esophageal cancer cells.
Author: Su, Huafang|Jin, Xiance|Shen, Lanxiao|Fang, Ya|Fei, Zhenghua|Zhang, Xuebang|Xie, Congying|Chen, Xiaolei
PMID: 26561473
Journal: Oncotarget. 2016 Jan 5;7(1):351-61.
Title: An hTERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to-mesenchymal transition (EMT) in colorectal cancer.
Author: Qin, Yong|Tang, Bo|Hu, Chang-Jiang|Xiao, Yu-Feng|Xie, Rui|Yong, Xin|Wu, Yu Yun|Dong, Hui|Yang, Shi-Ming
PMID: 26540342
Journal: Cancer Res Treat. 2017 Feb 24.
Title: Downregulation of HuR Inhibits the Progression of Esophageal Cancer Through Interleukin-18.
Author: Xu, Xiaohui|Song, Cheng|Chen, Zhihua|Yu, Chenxiao|Wang, Yi|Tang, Yiting|Luo, Judong
PMID: 28231690
Journal: Onco Targets Ther. 2017 Apr 20;10:2227-2237.
Title: Novel role of granulocyte-macrophage colony-stimulating factor: antitumor effects through inhibition of epithelial-to-mesenchymal transition in esophageal cancer.
Author: Zhang, Jingxin|Liu, Qiqi|Qiao, Lili|Hu, Pingping|Deng, Guodong|Liang, Ning|Xie, Jian|Luo, Hui|Zhang, Jiandong
PMID: 28461757
Journal: Mol Cancer Res. 2017 Jul;15(7):800-810.
Title: Aberrant Methylation-Mediated Silencing of lncRNA MEG3 Functions as a ceRNA in Esophageal Cancer.
Author: Dong, Zhiming|Zhang, Aili|Liu, Shengnan|Lu, Fan|Guo, Yanli|Zhang, Guoqiang|Xu, Fenglou|Shi, Yabin|Shen, Supeng|Liang, Jia|Guo, Wei
PMID: 28539329
Journal: Am J Cancer Res. 2017 Aug 1;7(8):1642-1653. eCollection 2017.
Title: FoxC1 promotes epithelial-mesenchymal transition through PBX1 dependent transactivation of ZEB2 in esophageal cancer.
Author: Zhu, Xiaoming|Wei, Li|Bai, Yangqiu|Wu, Sen|Han, Shuangyin
PMID: 28861321
Journal: Oncol Res. 2017 Sep 6.
Title: Swainsonine Inhibits Invasion and the EMT Process in Esophageal Carcinoma Cells by Targeting Twist1.
Author: Ma, Junxun|Wan, Lijie|Li, Jinyu|Zhang, Guoqing|Tao, Haitao|Li, Xiaoyan|Sun, Danyang|Hu, Yi
PMID: 28899457
Journal: Oncotarget. 2017 Jul 27;8(43):73372-73386.
Title: Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis.
Author: Alsaqer, Saqer F|Tashkandi, Mustafa M|Kartha, Vinay K|Yang, Ya-Ting|Alkheriji, Yazeed|Salama, Andrew|Varelas, Xaralabos|Kukuruzinska, Maria|Monti, Stefano|Bais, Manish V
PMID: 29088714
Journal: Oncotarget. 2017 Dec 1;9(1):853-865.
Title: Gli is activated and promotes epithelial-mesenchymal transition in human esophageal adenocarcinoma.
Author: Wang, Lei|Jin, Joy Q|Zhou, Yong|Tian, Ziqiang|Jablons, David M|He, Biao
PMID: 29416661
Journal: Food Chem Toxicol. 2018 Sep;119:380-386.
Title: Antrodia cinnamomea mycelial fermentation broth inhibits the epithelial-mesenchymal transition of human esophageal adenocarcinoma cancer cells.
Author: Liu, Yu-Ming|Liu, Yu-Kuo|Huang, Pin-I|Tsai, Tung-Hu|Chen, Yu-Jen
PMID: 29475041
Journal: Anticancer Drugs. 2018 Sep;29(8):767-773.
Title: LncRNA MALAT1 promotes epithelial-to-mesenchymal transition of esophageal cancer through Ezh2-Notch1 signaling pathway.
Author: Chen, Mingjiu|Xia, Zhenkun|Chen, Chen|Hu, Wen|Yuan, Yunchang
PMID: 29916899