Literatures

Primary Site >> Colorectal Cancer

Gene >> CD274

1.
Journal:	Int Immunol. 2005 Feb;17(2):133-44. Epub 2004 Dec 20.
Title:	PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells.
Author:	Iwai, Yoshiko\|Terawaki, Seigo\|Honjo, Tasuku
PMID:	15611321

2.
Journal:	Cancer Immun. 2007 Jun 26;7:10.
Title:	Focus on TILs: Prognostic significance of tumor infiltrating lymphocytes in human bladder cancer.
Author:	Liakou, Chrysoula I\|Narayanan, Sowmita\|Ng Tang, Derek\|Logothetis, Christopher J\|Sharma, Padmanee
PMID:	17591743

3.
Journal:	Clin Cancer Res. 2010 Dec 15;16(24):6019-28.
Title:	Simultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma model.
Author:	Yu, Ping\|Steel, Jason C\|Zhang, Meili\|Morris, John C\|Waldmann, Thomas A
PMID:	20924130

4.
Journal:	Clin Cancer Res. 2011 Sep 1;17(17):5668-73.
Title:	Activation of tumor-promoting type 2 macrophages by EGFR-targeting antibody cetuximab.
Author:	Pander, Jan\|Heusinkveld, Moniek\|van der Straaten, Tahar\|Jordanova, Ekaterina S\|Baak-Pablo, Renee\|Gelderblom, Hans\|Morreau, Hans\|van der Burg, Sjoerd H\|Guchelaar, Henk-Jan\|van Hall, Thorbald
PMID:	21788356

5.
Journal:	World J Gastroenterol. 2012 Mar 7;18(9):971-8.
Title:	B7-H1 expression is associated with expansion of regulatory T cells in colorectal carcinoma.
Author:	Hua, Dong\|Sun, Jing\|Mao, Yong\|Chen, Lu-Jun\|Wu, Yu-Yu\|Zhang, Xue-Guang
PMID:	22408358

6.
Journal:	Hepatology. 2012 Nov;56(5):1924-33.
Title:	Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance toward circulating carcinoembryonic antigen in mice.
Author:	Hochst, Bastian\|Schildberg, Frank A\|Bottcher, Jan\|Metzger, Christina\|Huss, Sebastian\|Turler, Andreas\|Overhaus, Markus\|Knoblich, Andreas\|Schneider, Berthold\|Pantelis, Dimitrios\|Kurts, Christian\|Kalff, Jorg C\|Knolle, Percy\|Diehl, Linda
PMID:	22610745

7.
Journal:	N Engl J Med. 2012 Jun 28;366(26):2443-54.
Title:	Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
Author:	Topalian, Suzanne L\|Hodi, F Stephen\|Brahmer, Julie R\|Gettinger, Scott N\|Smith, David C\|McDermott, David F\|Powderly, John D\|Carvajal, Richard D\|Sosman, Jeffrey A\|Atkins, Michael B\|Leming, Philip D\|Spigel, David R\|Antonia, Scott J\|Horn, Leora\|Drake, Charles
PMID:	22658127

8.
Journal:	N Engl J Med. 2012 Jun 28;366(26):2455-65.
Title:	Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.
Author:	Brahmer, Julie R\|Tykodi, Scott S\|Chow, Laura Q M\|Hwu, Wen-Jen\|Topalian, Suzanne L\|Hwu, Patrick\|Drake, Charles G\|Camacho, Luis H\|Kauh, John\|Odunsi, Kunle\|Pitot, Henry C\|Hamid, Omid\|Bhatia, Shailender\|Martins, Renato\|Eaton, Keith\|Chen, Shuming\|Salay, Theres
PMID:	22658128

9.
Journal:	Cancer Discov. 2012 Jul;2(7):608-23.
Title:	The HIF-1alpha hypoxia response in tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy.
Author:	Palazon, Asis\|Martinez-Forero, Ivan\|Teijeira, Alvaro\|Morales-Kastresana, Aizea\|Alfaro, Carlos\|Sanmamed, Miguel F\|Perez-Gracia, Jose Luis\|Penuelas, Ivan\|Hervas-Stubbs, Sandra\|Rouzaut, Ana\|de Landazuri, Manuel Ortiz\|Jure-Kunkel, Maria\|Aragones, Julian\|Meler
PMID:	22719018

10.
Journal:	Clin Cancer Res. 2012 Dec 15;18(24):6580-7.
Title:	Molecular pathways: next-generation immunotherapy--inhibiting programmed death-ligand 1 and programmed death-1.
Author:	Chen, Daniel S\|Irving, Bryan A\|Hodi, F Stephen
PMID:	23087408

11.
Journal:	Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 Nov;43(6):827-9, 859.
Title:	[Expression of Bcl-2, PD-L1 and its clinical significance in colorectal cancer].
Author:	Zhang, Mei-Yun\|Yang, Yong-Yan\|Wang, Xin-Hua\|Li, Xiao-Feng
PMID:	23387206

12.
Journal:	PLoS One. 2013;8(2):e57114.
Title:	Circulating and tumor-infiltrating myeloid-derived suppressor cells in patients with colorectal carcinoma.
Author:	Zhang, Bin\|Wang, Zhijun\|Wu, Liangliang\|Zhang, Meng\|Li, Wei\|Ding, Jianhua\|Zhu, Jun\|Wei, Huafeng\|Zhao, Ke
PMID:	23437326

13.
Journal:	Eur J Cancer. 2013 Jun;49(9):2233-42.
Title:	Clinical impact of programmed cell death ligand 1 expression in colorectal cancer.
Author:	Droeser, Raoul A\|Hirt, Christian\|Viehl, Carsten T\|Frey, Daniel M\|Nebiker, Christian\|Huber, Xaver\|Zlobec, Inti\|Eppenberger-Castori, Serenella\|Tzankov, Alexander\|Rosso, Raffaele\|Zuber, Markus\|Muraro, Manuele Giuseppe\|Amicarella, Francesca\|Cremonesi, Eleonor
PMID:	23478000

14.
Journal:	Cancer Res. 2013 Jun 15;73(12):3591-603.
Title:	Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors.
Author:	Duraiswamy, Jaikumar\|Kaluza, Karen M\|Freeman, Gordon J\|Coukos, George
PMID:	23633484

15.
Journal:	PLoS One. 2013 Jun 13;8(6):e65821.
Title:	PTEN loss increases PD-L1 protein expression and affects the correlation between PD-L1 expression and clinical parameters in colorectal cancer.
Author:	Song, Minmin\|Chen, Defeng\|Lu, Biyan\|Wang, Chenliang\|Zhang, Junxiao\|Huang, Lanlan\|Wang, Xiaoyan\|Timmons, Christine L\|Hu, Jun\|Liu, Bindong\|Wu, Xiaojian\|Wang, Lei\|Wang, Jianping\|Liu, Huanliang
PMID:	23785454

16.
Journal:	PLoS One. 2013 Oct 4;8(10):e76012.
Title:	B7-H1 expression is associated with poor prognosis in colorectal carcinoma and regulates the proliferation and invasion of HCT116 colorectal cancer cells.
Author:	Shi, Sheng-Jia\|Wang, Li-Juan\|Wang, Guo-Dong\|Guo, Zhang-Yan\|Wei, Ming\|Meng, Yan-Ling\|Yang, An-Gang\|Wen, Wei-Hong
PMID:	24124529

17.
Journal:	Tumour Biol. 2014 Jan;35(1):55-60.
Title:	T-cell infiltration and expressions of T lymphocyte co-inhibitory B7-H1 and B7-H4 molecules among colorectal cancer patients in northeast China's Heilongjiang province.
Author:	Liang, Ming\|Li, Jingyuan\|Wang, Dandan\|Li, Shuchen\|Sun, Yi\|Sun, Tiewei\|Zhang, Jing\|Chen, Xiaoning\|Li, Qiang\|Sun, Shibo
PMID:	23873101

18.
Journal:	Hum Immunol. 2014 Apr;75(4):348-53.
Title:	MiR-20b, -21, and -130b inhibit PTEN expression resulting in B7-H1 over-expression in advanced colorectal cancer.
Author:	Zhu, Jianjie\|Chen, Lanxin\|Zou, Lingting\|Yang, Panpan\|Wu, Ruirong\|Mao, Yong\|Zhou, Huan\|Li, Rui\|Wang, Kaicai\|Wang, Weipeng\|Hua, Dong\|Zhang, Xueguang
PMID:	24468585

19.
Journal:	Clin Cancer Res. 2014 Oct 1;20(19):5064-74.
Title:	Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy.
Author:	Taube, Janis M\|Klein, Alison\|Brahmer, Julie R\|Xu, Haiying\|Pan, Xiaoyu\|Kim, Jung H\|Chen, Lieping\|Pardoll, Drew M\|Topalian, Suzanne L\|Anders, Robert A
PMID:	24714771

20.
Journal:	Acta Histochem. 2014 Sep;116(7):1163-8.
Title:	B7-H1 and B7-H4 expression in colorectal carcinoma: correlation with tumor FOXP3(+) regulatory T-cell infiltration.
Author:	Zhao, Li-wei\|Li, Chun\|Zhang, Rui-lan\|Xue, Hao-gang\|Zhang, Fu-xi\|Zhang, Fan\|Gai, Xiao-dong
PMID:	25053455

21.
Journal:	Br J Cancer. 2014 Sep 23;111(7):1391-9.
Title:	PD-1(+) CD8(+) T cells are exhausted in tumours and functional in draining lymph nodes of colorectal cancer patients.
Author:	Wu, X\|Zhang, H\|Xing, Q\|Cui, J\|Li, J\|Li, Y\|Tan, Y\|Wang, S
PMID:	25093496

22.
Journal:	Acta Neuropathol. 2014 Dec;128(6):879-91.
Title:	Predictive molecular markers in metastases to the central nervous system: recent advances and future avenues.
Author:	Berghoff, Anna Sophie\|Bartsch, Rupert\|Wohrer, Adelheid\|Streubel, Berthold\|Birner, Peter\|Kros, Johan M\|Brastianos, Priscilla K\|von Deimling, Andreas\|Preusser, Matthias
PMID:	25287912

23.
Journal:	Cancer Epidemiol Biomarkers Prev. 2014 Dec;23(12):2965-70.
Title:	Programmed cell death 1 (PD-1) and its ligand (PD-L1) in common cancers and their correlation with molecular cancer type.
Author:	Gatalica, Zoran\|Snyder, Carrie\|Maney, Todd\|Ghazalpour, Anatole\|Holterman, Daniel A\|Xiao, Nianqing\|Overberg, Peggy\|Rose, Inga\|Basu, Gargi D\|Vranic, Semir\|Lynch, Henry T\|Von Hoff, Daniel D\|Hamid, Omid
PMID:	25392179

24.
Journal:	Cancer Discov. 2015 Jan;5(1):43-51.
Title:	The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints.
Author:	Llosa, Nicolas J\|Cruise, Michael\|Tam, Ada\|Wicks, Elizabeth C\|Hechenbleikner, Elizabeth M\|Taube, Janis M\|Blosser, Richard L\|Fan, Hongni\|Wang, Hao\|Luber, Brandon S\|Zhang, Ming\|Papadopoulos, Nickolas\|Kinzler, Kenneth W\|Vogelstein, Bert\|Sears, Cynthia L\|Ander
PMID:	25358689

25.
Journal:	Expert Opin Investig Drugs. 2015 Mar;24(3):329-44.
Title:	The potential role of immunotherapy to treat colorectal cancer.
Author:	Amin, Manik\|Lockhart, Albert Craig
PMID:	25519074

26.
Journal:	Cancer Discov. 2015 Jan;5(1):16-8.
Title:	The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy.
Author:	Xiao, Yanping\|Freeman, Gordon J
PMID:	25583798

27.
Journal:	Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E966-72.
Title:	Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK.
Author:	Sagiv-Barfi, Idit\|Kohrt, Holbrook E K\|Czerwinski, Debra K\|Ng, Patrick P\|Chang, Betty Y\|Levy, Ronald
PMID:	25730880

28.
Journal:	Mol Ther Nucleic Acids. 2015 Apr 28;4:e237.
Title:	Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers.
Author:	Prodeus, Aaron\|Abdul-Wahid, Aws\|Fischer, Nicholas W\|Huang, Eric H-B\|Cydzik, Marzena\|Gariepy, Jean
PMID:	25919090

29.
Journal:	Cancer Immunol Res. 2015 Sep;3(9):1052-62.
Title:	Identification and Characterization of MEDI4736, an Antagonistic Anti-PD-L1 Monoclonal Antibody.
Author:	Stewart, Ross\|Morrow, Michelle\|Hammond, Scott A\|Mulgrew, Kathy\|Marcus, Danielle\|Poon, Edmund\|Watkins, Amanda\|Mullins, Stefanie\|Chodorge, Matthieu\|Andrews, John\|Bannister, David\|Dick, Emily\|Crawford, Nicola\|Parmentier, Julie\|Alimzhanov, Marat\|Babcook, John
PMID:	25943534

30.
Journal:	Oncoimmunology. 2015 Apr 2;4(3):e976052.
Title:	An immunogenomic stratification of colorectal cancer: Implications for development of targeted immunotherapy.
Author:	Lal, Neeraj\|Beggs, Andrew D\|Willcox, Benjamin E\|Middleton, Gary W
PMID:	25949894

31.
Journal:	Semin Oncol. 2015 Jun;42(3):474-83.
Title:	PD-L1 blockade for cancer treatment: MEDI4736.
Author:	Ibrahim, Ramy\|Stewart, Ross\|Shalabi, Aiman
PMID:	25965366

32.
Journal:	PLoS One. 2015 Jun 26;10(6):e0131403.
Title:	PD-L1 and Survival in Solid Tumors: A Meta-Analysis.
Author:	Wu, Pin\|Wu, Dang\|Li, Lijun\|Chai, Ying\|Huang, Jian
PMID:	26114883

33.
Journal:	Oncoimmunology. 2015 Jun 5;4(7):e1058597.
Title:	Colorectal cancer: the first neoplasia found to be under immunosurveillance and the last one to respond to immunotherapy?
Author:	Kroemer, Guido\|Galluzzi, Lorenzo\|Zitvogel, Laurence\|Fridman, Wolf Herve
PMID:	26140250

34.
Journal:	Clin Cancer Res. 2015 Dec 15;21(24):5543-51.
Title:	Defining Effective Combinations of Immune Checkpoint Blockade and Oncolytic Virotherapy.
Author:	Rojas, Juan J\|Sampath, Padma\|Hou, Weizhou\|Thorne, Steve H
PMID:	26187615

35.
Journal:	Transl Res. 2015 Dec;166(6):721-732.e1.
Title:	Tumor-infiltrating lymphocytes, forkhead box P3, programmed death ligand-1, and cytotoxic T lymphocyte-associated antigen-4 expressions before and after neoadjuvant chemoradiation in rectal cancer.
Author:	Teng, Feifei\|Meng, Xiangjiao\|Kong, Li\|Mu, Dianbin\|Zhu, Hui\|Liu, Sujing\|Zhang, Jianbo\|Yu, Jinming
PMID:	26209749

36.
Journal:	PLoS One. 2015 Aug 18;10(8):e0135528.
Title:	B7H1 Expression and Epithelial-To-Mesenchymal Transition Phenotypes on Colorectal Cancer Stem-Like Cells.
Author:	Zhi, Yidan\|Mou, Zhirong\|Chen, Jun\|He, Yujun\|Dong, Hui\|Fu, Xiaolan\|Wu, Yuzhang
PMID:	26284927

37.
Journal:	Oncotarget. 2015 Sep 22;6(28):26483-93.
Title:	Genomic amplification of 9p24.1 targeting JAK2, PD-L1, and PD-L2 is enriched in high-risk triple negative breast cancer.
Author:	Barrett, Michael T\|Anderson, Karen S\|Lenkiewicz, Elizabeth\|Andreozzi, Mariacarla\|Cunliffe, Heather E\|Klassen, Christine L\|Dueck, Amylou C\|McCullough, Ann E\|Reddy, Srikanth K\|Ramanathan, Ramesh K\|Northfelt, Donald W\|Pockaj, Barbara A
PMID:	26317899

38.
Journal:	Am J Cancer Res. 2015 Jun 15;5(7):2277-84. eCollection 2015.
Title:	Correlation study of Bcl-2, B7-H1, EGFR, VEGF and colorectal cancer.
Author:	Li, Xiao-Feng\|Liu, Xian-Feng\|Yang, Yong-Yan\|Liu, Ai-Yong\|Zhang, Mei-Yun\|Bai, Xue-Feng\|Gao, Hui\|Guo, Xiao-Guang
PMID:	26328258

39.
Journal:	Curr Cancer Drug Targets. 2015;15(8):703-15.
Title:	Prognostic and Predictive Biomarkers in Colorectal Cancer. From the Preclinical Setting to Clinical Practice.
Author:	Maurel, Joan\|Postigo, Antonio
PMID:	26452385

40.
Journal:	Histopathology. 2016 Jul;69(1):158-60.
Title:	PD-L1 expression in tumour buds of colorectal carcinoma.
Author:	Prall, Friedrich\|Huhns, Maja
PMID:	26648188

41.
Journal:	J Proteome Res. 2016 Mar 4;15(3):755-65.
Title:	moCluster: Identifying Joint Patterns Across Multiple Omics Data Sets.
Author:	Meng, Chen\|Helm, Dominic\|Frejno, Martin\|Kuster, Bernhard
PMID:	26653205

42.
Journal:	Oncotarget. 2016 Jan 26;7(4):4522-30.
Title:	Identification of TIM3 2'-fluoro oligonucleotide aptamer by HT-SELEX for cancer immunotherapy.
Author:	Hervas-Stubbs, Sandra\|Soldevilla, Mario M\|Villanueva, Helena\|Mancheno, Uxua\|Bendandi, Maurizio\|Pastor, Fernando
PMID:	26683225

43.
Journal:	Mol Diagn Ther. 2016 Apr;20(2):175-81.
Title:	Significance of Programmed Death Ligand 1 (PD-L1) Immunohistochemical Expression in Colorectal Cancer.
Author:	Wang, Lisha\|Ren, Fei\|Wang, Qifeng\|Baldridge, Lee Ann\|Monn, M Francesca\|Fisher, Kurt W\|Sheng, Weiqi\|Zhou, Xiaoyan\|Du, Xiang\|Cheng, Liang
PMID:	26891728

44.
Journal:	Oncotarget. 2016 Mar 29;7(13):16130-45.
Title:	IL-15 superagonist/IL-15RalphaSushi-Fc fusion complex (IL-15SA/IL-15RalphaSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas.
Author:	Kim, Peter S\|Kwilas, Anna R\|Xu, Wenxin\|Alter, Sarah\|Jeng, Emily K\|Wong, Hing C\|Schlom, Jeffrey\|Hodge, James W
PMID:	26910920

45.
Journal:	Int J Clin Oncol. 2016 Oct;21(5):946-952.
Title:	Implication of programmed cell death ligand 1 expression in tumor recurrence and prognosis in rectal cancer with neoadjuvant chemoradiotherapy.
Author:	Saigusa, Susumu\|Toiyama, Yuji\|Tanaka, Koji\|Inoue, Yasuhiro\|Mori, Koichiro\|Ide, Shozo\|Imaoka, Hiroki\|Kawamura, Mikio\|Mohri, Yasuhiko\|Kusunoki, Masato
PMID:	26919982

46.
Journal:	Clin Cancer Res. 2016 Mar 1;22(5):1173-1184.
Title:	PD-1 Blockade Boosts Radiofrequency Ablation-Elicited Adaptive Immune Responses against Tumor.
Author:	Shi, Liangrong\|Chen, Lujun\|Wu, Changping\|Zhu, Yibei\|Xu, Bin\|Zheng, Xiao\|Sun, Mingfen\|Wen, Wen\|Dai, Xichao\|Yang, Min\|Lv, Quansheng\|Lu, Binfeng\|Jiang, Jingting
PMID:	26933175

47.
Journal:	Oncotarget. 2016 Mar 29;7(13):17035-46.
Title:	Intravenous administration of the selective toll-like receptor 7 agonist DSR-29133 leads to anti-tumor efficacy in murine solid tumor models which can be potentiated by combination with fractionated radiotherapy.
Author:	Dovedi, Simon J\|Adlard, Amy L\|Ota, Yosuke\|Murata, Masashi\|Sugaru, Eiji\|Koga-Yamakawa, Erina\|Eguchi, Ken\|Hirose, Yuko\|Yamamoto, Setsuko\|Umehara, Hiroki\|Honeychurch, Jamie\|Cheadle, Eleanor J\|Hughes, Gareth\|Jewsbury, Philip J\|Wilkinson, Robert W\|Stratford, I
PMID:	26959743

48.
Journal:	Mod Pathol. 2016 May;29(5):528-41.
Title:	Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment.
Author:	Friedman, Kenneth\|Brodsky, Alexander S\|Lu, Shaolei\|Wood, Stephanie\|Gill, Anthony J\|Lombardo, Kara\|Yang, Dongfang\|Resnick, Murray B
PMID:	26965581

49.
Journal:	Immunity. 2016 Mar 15;44(3):698-711.
Title:	Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability.
Author:	Mlecnik, Bernhard\|Bindea, Gabriela\|Angell, Helen K\|Maby, Pauline\|Angelova, Mihaela\|Tougeron, David\|Church, Sarah E\|Lafontaine, Lucie\|Fischer, Maria\|Fredriksen, Tessa\|Sasso, Maristella\|Bilocq, Amelie M\|Kirilovsky, Amos\|Obenauf, Anna C\|Hamieh, Mohamad\|Berge
PMID:	26982367

50.
Journal:	Gastroenterol Res Pract. 2016;2016:6261721.
Title:	Cancer-Associated Immune Resistance and Evasion of Immune Surveillance in Colorectal Cancer.
Author:	Parcesepe, Pietro\|Giordano, Guido\|Laudanna, Carmelo\|Febbraro, Antonio\|Pancione, Massimo
PMID:	27006653

51.
Journal:	Eur J Cancer. 2016 May;59:160-170.
Title:	Immunotherapy in gastrointestinal cancer: Recent results, current studies and future perspectives.
Author:	Moehler, Markus\|Delic, Maike\|Goepfert, Katrin\|Aust, Daniela\|Grabsch, Heike I\|Halama, Niels\|Heinrich, Bernd\|Julie, Catherine\|Lordick, Florian\|Lutz, Manfred P\|Mauer, Murielle\|Alsina Maqueda, Maria\|Schild, Hansjoerg\|Schimanski, Carl C\|Wagner, Anna-Dorothea\|R
PMID:	27039171

52.
Journal:	J Immunother. 2016 May;39(4):171-80.
Title:	Targeting PD-1 and Tim-3 Pathways to Reverse CD8 T-Cell Exhaustion and Enhance Ex Vivo T-Cell Responses to Autologous Dendritic/Tumor Vaccines.
Author:	Liu, Jingwei\|Zhang, Shurong\|Hu, Yuefeng\|Yang, Zhaomin\|Li, Jingpo\|Liu, Xuesong\|Deng, Lijuan\|Wang, Yue\|Zhang, Xiaoyan\|Jiang, Ting\|Lu, Xu
PMID:	27070448

53.
Journal:	Cancer Gene Ther. 2016 May;23(5):142-8.
Title:	Regional CAR-T cell infusions for peritoneal carcinomatosis are superior to systemic delivery.
Author:	Katz, S C\|Point, G R\|Cunetta, M\|Thorn, M\|Guha, P\|Espat, N J\|Boutros, C\|Hanna, N\|Junghans, R P
PMID:	27080226

54.
Journal:	Genes Chromosomes Cancer. 2016 Aug;55(8):626-39.
Title:	Pan-cancer analysis of copy number changes in programmed death-ligand 1 (PD-L1, CD274) - associations with gene expression, mutational load, and survival.
Author:	Budczies, Jan\|Bockmayr, Michael\|Denkert, Carsten\|Klauschen, Frederick\|Groschel, Stefan\|Darb-Esfahani, Silvia\|Pfarr, Nicole\|Leichsenring, Jonas\|Onozato, Maristela L\|Lennerz, Jochen K\|Dietel, Manfred\|Frohling, Stefan\|Schirmacher, Peter\|Iafrate, A John\|Weich
PMID:	27106868

55.
Journal:	World J Gastroenterol. 2016 May 7;22(17):4275-86.
Title:	Dendritic cell-based cancer immunotherapy for colorectal cancer.
Author:	Kajihara, Mikio\|Takakura, Kazuki\|Kanai, Tomoya\|Ito, Zensho\|Saito, Keisuke\|Takami, Shinichiro\|Shimodaira, Shigetaka\|Okamoto, Masato\|Ohkusa, Toshifumi\|Koido, Shigeo
PMID:	27158196

56.
Journal:	Cancer Immunol Res. 2016 Jul;4(7):582-91.
Title:	Immune-Derived PD-L1 Gene Expression Defines a Subgroup of Stage II/III Colorectal Cancer Patients with Favorable Prognosis Who May Be Harmed by Adjuvant Chemotherapy.
Author:	Dunne, Philip D\|McArt, Darragh G\|O'Reilly, Paul G\|Coleman, Helen G\|Allen, Wendy L\|Loughrey, Maurice\|Van Schaeybroeck, Sandra\|McDade, Simon\|Salto-Tellez, Manuel\|Longley, Daniel B\|Lawler, Mark\|Johnston, Patrick G
PMID:	27197062

57.
Journal:	Mod Pathol. 2016 Sep;29(9):1104-12.
Title:	PD-L1 expression in colorectal cancer is associated with microsatellite instability, BRAF mutation, medullary morphology and cytotoxic tumor-infiltrating lymphocytes.
Author:	Rosenbaum, Matthew W\|Bledsoe, Jacob R\|Morales-Oyarvide, Vicente\|Huynh, Tiffany G\|Mino-Kenudson, Mari
PMID:	27198569

58.
Journal:	Steroids. 2016 Oct;114:59-67.
Title:	Actions of l-thyroxine and Nano-diamino-tetrac (Nanotetrac) on PD-L1 in cancer cells.
Author:	Lin, Hung-Yun\|Chin, Yu-Tang\|Nana, Andre Wendindonde\|Shih, Ya-Jung\|Lai, Hsuan-Yu\|Tang, Heng-Yuan\|Leinung, Matthew\|Mousa, Shaker A\|Davis, Paul J
PMID:	27221508

59.
Journal:	Drugs. 2016 Jun;76(9):925-45.
Title:	Cancer Treatment with Anti-PD-1/PD-L1 Agents: Is PD-L1 Expression a Biomarker for Patient Selection?
Author:	Festino, Lucia\|Botti, Gerardo\|Lorigan, Paul\|Masucci, Giuseppe V\|Hipp, Jason D\|Horak, Christine E\|Melero, Ignacio\|Ascierto, Paolo A
PMID:	27229745

60.
Journal:	Oncotarget. 2016 Jul 19;7(29):45370-45384.
Title:	The tumor suppressor miR-138-5p targets PD-L1 in colorectal cancer.
Author:	Zhao, Lian\|Yu, Haibo\|Yi, Shuijing\|Peng, Xiaowei\|Su, Peng\|Xiao, Zhiming\|Liu, Rui\|Tang, Anliu\|Li, Xiayu\|Liu, Fen\|Shen, Shourong
PMID:	27248318

61.
Journal:	J Cancer Res Clin Oncol. 2016 Aug;142(8):1775-80.
Title:	Prognostic relevance of genetic variants involved in immune checkpoints in patients with colorectal cancer.
Author:	Yoon, Shinkyo\|Kang, Byung Woog\|Park, Su Yeon\|Kim, Hye Jin\|Park, Jun Seok\|Choi, Gyu Seog\|Kim, Jong Gwang
PMID:	27339628

62.
Journal:	Bull Cancer. 2016 Jul-Aug;103(7-8):643-50.
Title:	[New molecular classification of colorectal cancer, pancreatic cancer and stomach cancer: Towards "a la carte" treatment?].
Author:	Dreyer, Chantal\|Afchain, Pauline\|Trouilloud, Isabelle\|Andre, Thierry
PMID:	27345450

63.
Journal:	Sci Rep. 2016 Jul 1;6:28910.
Title:	Potential role of nuclear PD-L1 expression in cell-surface vimentin positive circulating tumor cells as a prognostic marker in cancer patients.
Author:	Satelli, Arun\|Batth, Izhar Singh\|Brownlee, Zachary\|Rojas, Christina\|Meng, Qing H\|Kopetz, Scott\|Li, Shulin
PMID:	27363678

64.
Journal:	Mod Pathol. 2016 Nov;29(11):1433-1442.
Title:	Patterns and prognostic relevance of PD-1 and PD-L1 expression in colorectal carcinoma.
Author:	Lee, Lik Hang\|Cavalcanti, Marcela S\|Segal, Neil H\|Hechtman, Jaclyn F\|Weiser, Martin R\|Smith, J Joshua\|Garcia-Aguilar, Julio\|Sadot, Eran\|Ntiamoah, Peter\|Markowitz, Arnold J\|Shike, Moshe\|Stadler, Zsofia K\|Vakiani, Efsevia\|Klimstra, David S\|Shia, Jinru
PMID:	27443512

65.
Journal:	Evid Based Complement Alternat Med. 2016;2016:7503726.
Title:	Antitumor Effect of Zhihuang Fuzheng Soft Capsules on Tumor-Bearing Mice.
Author:	Bao, Yanyan\|Pan, Xin\|Jin, Yahong\|Gao, Yingjie\|Cui, Xiaolan
PMID:	27493673

66.
Journal:	Oncotarget. 2016 Sep 27;7(39):63093-63105.
Title:	Visceral fat adipocytes from obese and colorectal cancer subjects exhibit distinct secretory and omega6 polyunsaturated fatty acid profiles and deliver immunosuppressive signals to innate immunity cells.
Author:	Del Corno, Manuela\|D'Archivio, Massimo\|Conti, Lucia\|Scazzocchio, Beatrice\|Vari, Rosaria\|Donninelli, Gloria\|Varano, Barbara\|Giammarioli, Stefania\|De Meo, Simone\|Silecchia, Gianfranco\|Pennestri, Francesco\|Persiani, Roberto\|Masella, Roberta\|Gessani, Sandra
PMID:	27494857

67.
Journal:	Cancer Res. 2016 Sep 15;76(18):5241-52.
Title:	Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX-Bevacizumab Drug Treatment Regimen.
Author:	Limagne, Emeric\|Euvrard, Romain\|Thibaudin, Marion\|Rebe, Cedric\|Derangere, Valentin\|Chevriaux, Angelique\|Boidot, Romain\|Vegran, Frederique\|Bonnefoy, Nathalie\|Vincent, Julie\|Bengrine-Lefevre, Leila\|Ladoire, Sylvain\|Delmas, Dominique\|Apetoh, Lionel\|Ghiringhe
PMID:	27496709

68.
Journal:	Nat Commun. 2016 Aug 17;7:12499.
Title:	Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy.
Author:	He, Chunbai\|Duan, Xiaopin\|Guo, Nining\|Chan, Christina\|Poon, Christopher\|Weichselbaum, Ralph R\|Lin, Wenbin
PMID:	27530650

69.
Journal:	Mol Cancer. 2016 Aug 24;15(1):55.
Title:	Prognostic impact of programed cell death-1 (PD-1) and PD-ligand 1 (PD-L1) expression in cancer cells and tumor infiltrating lymphocytes in colorectal cancer.
Author:	Li, Yaqi\|Liang, Lei\|Dai, Weixing\|Cai, Guoxiang\|Xu, Ye\|Li, Xinxiang\|Li, Qingguo\|Cai, Sanjun
PMID:	27552968

70.
Journal:	Clin Colorectal Cancer. 2016 Dec;15(4):285-291.
Title:	The Potential Value of Immunotherapy in Colorectal Cancers: Review of the Evidence for Programmed Death-1 Inhibitor Therapy.
Author:	Toh, James W T\|de Souza, Paul\|Lim, Stephanie H\|Singh, Puneet\|Chua, Wei\|Ng, Weng\|Spring, Kevin J
PMID:	27553906

71.
Journal:	Onco Targets Ther. 2016 Aug 12;9:5023-39.
Title:	PD-L1 expression in human cancers and its association with clinical outcomes.
Author:	Wang, Xin\|Teng, Feifei\|Kong, Li\|Yu, Jinming
PMID:	27574444

72.
Journal:	Oncoimmunology. 2016 Mar 28;5(7):e1164918.
Title:	Myeloid PTEN deficiency impairs tumor-immune surveillance via immune-checkpoint inhibition.
Author:	Kuttke, M\|Sahin, E\|Pisoni, J\|Percig, S\|Vogel, A\|Kraemmer, D\|Hanzl, L\|Brunner, J S\|Paar, H\|Soukup, K\|Halfmann, A\|Dohnal, A M\|Steiner, C W\|Bluml, S\|Basilio, J\|Hochreiter, B\|Salzmann, M\|Hoesel, B\|Lametschwandtner, G\|Eferl, R\|Schmid, J A\|Schabbauer, G
PMID:	27622019

73.
Journal:	Cancer Res. 2016 Dec 1;76(23):6988-7000.
Title:	Efficacy of Cotargeting Angiopoietin-2 and the VEGF Pathway in the Adjuvant Postsurgical Setting for Early Breast, Colorectal, and Renal Cancers.
Author:	Wu, Florence T H\|Man, Shan\|Xu, Ping\|Chow, Annabelle\|Paez-Ribes, Marta\|Lee, Christina R\|Pirie-Shepherd, Steven R\|Emmenegger, Urban\|Kerbel, Robert S
PMID:	27651308

74.
Journal:	J Immunother Cancer. 2016 Oct 18;4:65.
Title:	5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers.
Author:	Van Der Kraak, Lauren\|Goel, Gaurav\|Ramanan, Krishnaveni\|Kaltenmeier, Christof\|Zhang, Lin\|Normolle, Daniel P\|Freeman, Gordon J\|Tang, Daolin\|Nason, Katie S\|Davison, Jon M\|Luketich, James D\|Dhupar, Rajeev\|Lotze, Michael T
PMID:	27777774

75.
Journal:	Cancer Treat Rev. 2016 Dec;51:19-26.
Title:	The evolving role of microsatellite instability in colorectal cancer: A review.
Author:	Gelsomino, Fabio\|Barbolini, Monica\|Spallanzani, Andrea\|Pugliese, Giuseppe\|Cascinu, Stefano
PMID:	27838401

76.
Journal:	Eur Surg. 2016;48(6):352-356.
Title:	Programmed death-ligand 1 expression in rectal cancer.
Author:	Jomrich, G\|Silberhumer, G R\|Marian, B\|Beer, A\|Mullauer, L
PMID:	28058043

77.
Journal:	Oncoimmunology. 2016 Oct 20;5(12):e1247135.
Title:	The expression profiles and regulation of PD-L1 in tumor-induced myeloid-derived suppressor cells.
Author:	Lu, Chunwan\|Redd, Priscilla S\|Lee, Jeffrey R\|Savage, Natasha\|Liu, Kebin
PMID:	28123883

78.
Journal:	Oncoimmunology. 2016 Nov 29;5(12):e1254313.
Title:	CXCR4-CXCL12-CXCR7, TLR2-TLR4, and PD-1/PD-L1 in colorectal cancer liver metastases from neoadjuvant-treated patients.
Author:	D'Alterio, Crescenzo\|Nasti, Guglielmo\|Polimeno, Marianeve\|Ottaiano, Alessandro\|Conson, Manuel\|Circelli, Luisa\|Botti, Giovanni\|Scognamiglio, Giosue\|Santagata, Sara\|De Divitiis, Chiara\|Nappi, Anna\|Napolitano, Maria\|Tatangelo, Fabiana\|Pacelli, Roberto\|Izzo,
PMID:	28123896

79.
Journal:	Signal Transduct Target Ther. 2016 Nov 18;1:16025.
Title:	A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity.
Author:	Tian, Hongwei\|Shi, Gang\|Wang, Qin\|Li, Yiming\|Yang, Qianmei\|Li, Chunlei\|Yang, Guoyou\|Wu, Min\|Xie, Qian\|Zhang, Shuang\|Yang, Yang\|Xiang, Rong\|Yu, Dechao\|Wei, Yuquan\|Deng, Hongxin
PMID:	29263903

80.
Journal:	Melanoma Manag. 2016 Sep;3(3):187-194.
Title:	PD-L1 in melanoma: facts and myths.
Author:	Mandala, Mario\|Merelli, Barbara\|Massi, Daniela
PMID:	30190888

81.
Journal:	Gut. 2017 Aug;66(8):1463-1473.
Title:	Tumour CD274 (PD-L1) expression and T cells in colorectal cancer.
Author:	Masugi, Yohei\|Nishihara, Reiko\|Yang, Juhong\|Mima, Kosuke\|da Silva, Annacarolina\|Shi, Yan\|Inamura, Kentaro\|Cao, Yin\|Song, Mingyang\|Nowak, Jonathan A\|Liao, Xiaoyun\|Nosho, Katsuhiko\|Chan, Andrew T\|Giannakis, Marios\|Bass, Adam J\|Hodi, F Stephen\|Freeman, Gordo
PMID:	27196573

82.
Journal:	Int J Biol Markers. 2017 Mar 2;32(1):e68-e74.
Title:	Prognostic role of PD-L1 in malignant solid tumors: a meta-analysis.
Author:	Pyo, Jung-Soo\|Kang, Guhyun\|Kim, Jung Yeon
PMID:	27470134

83.
Journal:	Mod Pathol. 2017 Feb;30(2):278-285.
Title:	Clinicopathologic profile, immunophenotype, and genotype of CD274 (PD-L1)-positive colorectal carcinomas.
Author:	Inaguma, Shingo\|Lasota, Jerzy\|Wang, Zengfeng\|Felisiak-Golabek, Anna\|Ikeda, Hiroshi\|Miettinen, Markku
PMID:	27813511

84.
Journal:	Curr Med Res Opin. 2017 Apr;33(4):749-759.
Title:	Targeting the PD-1 pathway: a new hope for gastrointestinal cancers.
Author:	Bilgin, Burak\|Sendur, Mehmet A N\|Bulent Akinci, Muhammed\|Sener Dede, Didem\|Yalcin, Bulent
PMID:	28055269

85.
Journal:	Clin Exp Pharmacol Physiol. 2017 May;44(5):602-604.
Title:	Increased PD-L1 expression in breast and colon cancer stem cells.
Author:	Wu, Yanheng\|Chen, Mingshui\|Wu, Peihong\|Chen, Chen\|Xu, Zhi Ping\|Gu, Wenyi
PMID:	28107571

86.
Journal:	Oncoimmunology. 2016 Nov 10;6(1):e1257454.
Title:	PD-L1 (CD274) promoter methylation predicts survival in colorectal cancer patients.
Author:	Goltz, Diane\|Gevensleben, Heidrun\|Dietrich, Jorn\|Dietrich, Dimo
PMID:	28197377

87.
Journal:	Curr Opin Immunol. 2017 Apr;45:60-72.
Title:	Immunoprofiling as a predictor of patient's response to cancer therapy-promises and challenges.
Author:	Bethmann, Daniel\|Feng, Zipei\|Fox, Bernard A
PMID:	28222333

88.
Journal:	Immunol Lett. 2017 Apr;184:7-14.
Title:	Inflammatory cytokines IL-17 and TNF-alpha up-regulate PD-L1 expression in human prostate and colon cancer cells.
Author:	Wang, Xun\|Yang, Lingyun\|Huang, Feng\|Zhang, Qiuyang\|Liu, Sen\|Ma, Lin\|You, Zongbing
PMID:	28223102

89.
Journal:	Cancer Sci. 2017 May;108(5):853-858.
Title:	Prognostic value of programmed death-ligand 1 expression in patients with stage III colorectal cancer.
Author:	Koganemaru, Shigehiro\|Inoshita, Naoko\|Miura, Yuji\|Miyama, Yu\|Fukui, Yudai\|Ozaki, Yukinori\|Tomizawa, Kenji\|Hanaoka, Yutaka\|Toda, Shigeo\|Suyama, Koichi\|Tanabe, Yuko\|Moriyama, Jin\|Fujii, Takeshi\|Matoba, Shuichiro\|Kuroyanagi, Hiroya\|Takano, Toshimi
PMID:	28267224

90.
Journal:	Immunol Invest. 2017 Apr;46(3):221-238.
Title:	Immunomodulating and Immunoresistance Properties of Cancer-Initiating Cells: Implications for the Clinical Success of Immunotherapy.
Author:	Maccalli, Cristina\|Parmiani, Giorgio\|Ferrone, Soldano
PMID:	28287848

91.
Journal:	Anticancer Res. 2017 Apr;37(4):1947-1955.
Title:	Evaluation of Prognostic Immune Signatures in Patients with Breast, Colorectal and Pancreatic Cancer Receiving Chemotherapy.
Author:	Vogl, Ursula M\|Ohler, Leopold\|Rasic, Masa\|Frischer, Josa M\|Modak, Madhura\|Stockl, Johannes
PMID:	28373465

92.
Journal:	Histopathology. 2017 Sep;71(3):366-374.
Title:	The PD-1 expressing immune phenotype of T cell exhaustion is prominent in the 'immunoreactive' microenvironment of colorectal carcinoma.
Author:	Prall, Friedrich\|Huhns, Maja
PMID:	28383777

93.
Journal:	Cancer Immunol Immunother. 2017 Jul;66(7):927-939.
Title:	Prognostic implication of CD274 (PD-L1) protein expression in tumor-infiltrating immune cells for microsatellite unstable and stable colorectal cancer.
Author:	Lee, Kyu Sang\|Kwak, Yoonjin\|Ahn, Soyeon\|Shin, Eun\|Oh, Heung-Kwon\|Kim, Duck-Woo\|Kang, Sung-Bum\|Choe, Gheeyoung\|Kim, Woo Ho\|Lee, Hye Seung
PMID:	28405764

94.
Journal:	J Clin Oncol. 2017 Jun 1;35(16):1836-1844.
Title:	Aspirin Use and Colorectal Cancer Survival According to Tumor CD274 (Programmed Cell Death 1 Ligand 1) Expression Status.
Author:	Hamada, Tsuyoshi\|Cao, Yin\|Qian, Zhi Rong\|Masugi, Yohei\|Nowak, Jonathan A\|Yang, Juhong\|Song, Mingyang\|Mima, Kosuke\|Kosumi, Keisuke\|Liu, Li\|Shi, Yan\|da Silva, Annacarolina\|Gu, Mancang\|Li, Wanwan\|Keum, NaNa\|Zhang, Xuehong\|Wu, Kana\|Meyerhardt, Jeffrey A\|Giova
PMID:	28406723

95.
Journal:	Oncotarget. 2017 Apr 18;8(16):27189-27198.
Title:	The antitumor activity and preliminary modeling on the potential mechanism of action of human peroxiredoxin-5.
Author:	Liu, Juanjuan\|Feng, Xiaozhou\|Jin, Yuanyuan\|Sun, Zhengyang\|Meng, Haoyi\|Zhang, Zhifei\|Hu, Laixing\|Yang, Zhaoyong
PMID:	28423711

96.
Journal:	Ann Oncol. 2017 Aug 1;28(8):1996-2001.
Title:	Circulating tumor DNA changes for early monitoring of anti-PD1 immunotherapy: a proof-of-concept study.
Author:	Cabel, L\|Riva, F\|Servois, V\|Livartowski, A\|Daniel, C\|Rampanou, A\|Lantz, O\|Romano, E\|Milder, M\|Buecher, B\|Piperno-Neumann, S\|Bernard, V\|Baulande, S\|Bieche, I\|Pierga, J Y\|Proudhon, C\|Bidard, F-C
PMID:	28459943

97.
Journal:	Nature. 2017 May 25;545(7655):495-499.
Title:	PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity.
Author:	Gordon, Sydney R\|Maute, Roy L\|Dulken, Ben W\|Hutter, Gregor\|George, Benson M\|McCracken, Melissa N\|Gupta, Rohit\|Tsai, Jonathan M\|Sinha, Rahul\|Corey, Daniel\|Ring, Aaron M\|Connolly, Andrew J\|Weissman, Irving L
PMID:	28514441

98.
Journal:	ACS Nano. 2017 Jun 27;11(6):5417-5429.
Title:	Dual Targeting Nanoparticle Stimulates the Immune System To Inhibit Tumor Growth.
Author:	Kosmides, Alyssa K\|Sidhom, John-William\|Fraser, Andrew\|Bessell, Catherine A\|Schneck, Jonathan P
PMID:	28589725

99.
Journal:	Br J Cancer. 2017 Jul 11;117(2):203-209.
Title:	Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies.
Author:	Alvi, Muhammad A\|Loughrey, Maurice B\|Dunne, Philip\|McQuaid, Stephen\|Turkington, Richard\|Fuchs, Marc-Aurel\|McGready, Claire\|Bingham, Victoria\|Pang, Brendan\|Moore, Wendy\|Maxwell, Perry\|Lawler, Mark\|James, Jacqueline A\|Murray, Graeme I\|Wilson, Richard H\|Salt
PMID:	28595259

100.
Journal:	Virchows Arch. 2017 Sep;471(3):329-336.
Title:	Intratumoral Fusobacterium nucleatum abundance correlates with macrophage infiltration and CDKN2A methylation in microsatellite-unstable colorectal carcinoma.
Author:	Park, Hye Eun\|Kim, Jung Ho\|Cho, Nam-Yun\|Lee, Hye Seung\|Kang, Gyeong Hoon
PMID:	28597080

101.
Journal:	Sichuan Da Xue Xue Bao Yi Xue Ban. 2017 Jan;48(1):33-40.
Title:	[Bone Morphogenetic Proteins from CT26 Regulate the Expression of PD-L1 in Murine Dendritic Cells and Macrophages].
Author:	Zhao, Mao-Yuan\|Wang, Yu-Yi\|Du, Chi\|Luo, Feng
PMID:	28612555

102.
Journal:	Int J Mol Sci. 2017 Jun 21;18(6). pii: ijms18061324.
Title:	Immune Checkpoints as a Target for Colorectal Cancer Treatment.
Author:	Passardi, Alessandro\|Canale, Matteo\|Valgiusti, Martina\|Ulivi, Paola
PMID:	28635639

103.
Journal:	Oncol Lett. 2017 Jul;14(1):958-964.
Title:	MLH1 expression predicts the response to preoperative therapy and is associated with PD-L1 expression in esophageal cancer.
Author:	Momose, Kota\|Yamasaki, Makoto\|Tanaka, Koji\|Miyazaki, Yasuhiro\|Makino, Tomoki\|Takahashi, Tsuyoshi\|Kurokawa, Yukinori\|Nakajima, Kiyokazu\|Takiguchi, Shuji\|Mori, Masaki\|Doki, Yuichiro
PMID:	28693258

104.
Journal:	Cancer Manag Res. 2017 Jun 29;9:249-258.
Title:	Tumor cell PD-L1 predicts poor local control for rectal cancer patients following neoadjuvant radiotherapy.
Author:	Shao, Lingdong\|Peng, Qingqin\|Du, Kaixin\|He, Junyan\|Dong, Yaping\|Lin, Xiaoyi\|Li, Jinluan\|Wu, Junxin
PMID:	28721097

105.
Journal:	Cancer Biol Ther. 2017 Sep 2;18(9):651-654.
Title:	Mismatch repair deficient metastatic colon cancer and urothelial cancer: A case report of sequential immune checkpoint therapy.
Author:	Ghatalia, Pooja\|Nagarathinam, Rajeswari\|Cooper, Harry\|Geynisman, Daniel M\|El-Deiry, Wafik S
PMID:	28726535

106.
Journal:	Oncoimmunology. 2017 May 16;6(7):e1327494.
Title:	PD-L2 expression in colorectal cancer: Independent prognostic effect and targetability by deglycosylation.
Author:	Wang, Huanbin\|Yao, Han\|Li, Chushu\|Liang, Lunxi\|Zhang, Yao\|Shi, Hubing\|Zhou, Chongzhi\|Chen, Yingxuan\|Fang, Jing-Yuan\|Xu, Jie
PMID:	28811964

107.
Journal:	J Dig Dis. 2017 Oct;18(10):574-581.
Title:	Rise of PD-L1 expression during metastasis of colorectal cancer: Implications for immunotherapy.
Author:	Wang, Huan Bin\|Yao, Han\|Li, Chu Shu\|Liang, Lun Xi\|Zhang, Yao\|Chen, Ying Xuan\|Fang, Jing-Yuan\|Xu, Jie
PMID:	28851046

108.
Journal:	Oncotarget. 2017 Jun 3;8(34):57889-57897.
Title:	Pseudoprogression in microsatellite instability-high colorectal cancer during treatment with combination T cell mediated immunotherapy: a case report and literature review.
Author:	Chae, Young Kwang\|Wang, Si\|Nimeiri, Halla\|Kalyan, Aparna\|Giles, Francis J
PMID:	28915720

109.
Journal:	Oncoimmunology. 2017 Aug 18;6(9):e1331194.
Title:	PD1-positive tumor-infiltrating lymphocytes are associated with poor clinical outcome after pulmonary metastasectomy for colorectal cancer.
Author:	Kollmann, Dagmar\|Schweiger, Thomas\|Schwarz, Stefan\|Ignatova, Desislava\|Chang, Yun-Tsan\|Lewik, Gerrit\|Schoppmann, Sebastian F\|Hoetzenecker, Wolfram\|Klepetko, Walter\|Guenova, Emmanuella\|Hoetzenecker, Konrad
PMID:	28932634

110.
Journal:	Oncotarget. 2017 Jul 26;8(35):58948-58963.
Title:	PEGylated arginine deiminase can modulate tumor immune microenvironment by affecting immune checkpoint expression, decreasing regulatory T cell accumulation and inducing tumor T cell infiltration.
Author:	Brin, Elena\|Wu, Katherine\|Lu, Hsin-Tze\|He, Yudou\|Dai, Zhaoming\|He, Wei
PMID:	28938609

111.
Journal:	Pathol Res Pract. 2017 Dec;213(12):1552-1555.
Title:	PD-L1 expression in HNPCC-associated colorectal cancer.
Author:	Shiraliyeva, Naila\|Friedrichs, Jacqueline\|Buettner, Reinhard\|Friedrichs, Nicolaus
PMID:	29033182

112.
Journal:	Cancer Immunol Res. 2017 Nov;5(11):1046-1055.
Title:	Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer.
Author:	Masugi, Yohei\|Nishihara, Reiko\|Hamada, Tsuyoshi\|Song, Mingyang\|da Silva, Annacarolina\|Kosumi, Keisuke\|Gu, Mancang\|Shi, Yan\|Li, Wanwan\|Liu, Li\|Nevo, Daniel\|Inamura, Kentaro\|Cao, Yin\|Liao, Xiaoyun\|Nosho, Katsuhiko\|Chan, Andrew T\|Giannakis, Marios\|Bass, Adam
PMID:	29038297

113.
Journal:	J Pathol Clin Res. 2017 Oct 7;3(4):268-278.
Title:	Histopathological and genotypic characterization of metastatic colorectal carcinoma with PD-L1 (CD274)-expression: Possible roles of tumour micro environmental factors for CD274 expression.
Author:	Inaguma, Shingo\|Lasota, Jerzy\|Felisiak-Golabek, Anna\|Kowalik, Artur\|Wang, Zengfeng\|Zieba, Sebastian\|Kalisz, Joanna\|Ikeda, Hiroshi\|Miettinen, Markku
PMID:	29085667

114.
Journal:	Front Pharmacol. 2017 Oct 18;8:730.
Title:	Immune-Related Adverse Events Associated with Anti-PD-1/PD-L1 Treatment for Malignancies: A Meta-Analysis.
Author:	Wang, Peng-Fei\|Chen, Yang\|Song, Si-Ying\|Wang, Ting-Jian\|Ji, Wen-Jun\|Li, Shou-Wei\|Liu, Ning\|Yan, Chang-Xiang
PMID:	29093678

115.
Journal:	Pathology. 2017 Dec;49(7):721-730.
Title:	The prognostic value of cancer stem-like cell markers SOX2 and CD133 in stage III colon cancer is modified by expression of the immune-related markers FoxP3, PD-L1 and CD3.
Author:	Miller, T J\|McCoy, M J\|Hemmings, C\|Bulsara, M K\|Iacopetta, B\|Platell, C F
PMID:	29102042

116.
Journal:	Oncotarget. 2017 Jul 25;8(45):79793-79802.
Title:	Prediction of radio-responsiveness with immune-profiling in patients with rectal cancer.
Author:	Park, In Ja\|An, Soyeon\|Kim, Sang-Yeob\|Lim, Hye Min\|Hong, Seung-Mo\|Kim, Mi-Ju\|Kim, Yun Jae\|Yu, Chang Sik
PMID:	29108360

117.
Journal:	Surg Oncol. 2017 Dec;26(4):368-376.
Title:	The role of intestinal bacteria in the development and progression of gastrointestinal tract neoplasms.
Author:	Mima, Kosuke\|Ogino, Shuji\|Nakagawa, Shigeki\|Sawayama, Hiroshi\|Kinoshita, Koichi\|Krashima, Ryuichi\|Ishimoto, Takatsugu\|Imai, Katsunori\|Iwatsuki, Masaaki\|Hashimoto, Daisuke\|Baba, Yoshifumi\|Sakamoto, Yasuo\|Yamashita, Yo-Ichi\|Yoshida, Naoya\|Chikamoto, Akira\|I
PMID:	29113654

118.
Journal:	Oncotarget. 2017 Aug 14;8(49):85526-85536.
Title:	Impact of mismatch-repair deficiency on the colorectal cancer immune microenvironment.
Author:	Zhang, Yingyi\|Sun, Zhao\|Mao, Xinxin\|Wu, Huanwen\|Luo, Fei\|Wu, Xi\|Zhou, Liangrui\|Qin, Jing\|Zhao, Lin\|Bai, Chunmei
PMID:	29156738

119.
Journal:	Klin Onkol. 2017 Winter;30(Supplementum3):62-65.
Title:	[Immunotherapy of Colorectal and Anal Carcinoma].
Author:	Tomasek, J\|Kiss, I
PMID:	29239195

120.
Journal:	PLoS One. 2017 Dec 28;12(12):e0189848.
Title:	Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with advanced colorectal carcinoma.
Author:	O'Neil, Bert H\|Wallmark, John M\|Lorente, David\|Elez, Elena\|Raimbourg, Judith\|Gomez-Roca, Carlos\|Ejadi, Samuel\|Piha-Paul, Sarina A\|Stein, Mark N\|Abdul Razak, Albiruni R\|Dotti, Katia\|Santoro, Armando\|Cohen, Roger B\|Gould, Marlena\|Saraf, Sanatan\|Stein, Karen
PMID:	29284010

121.
Journal:	NPJ Precis Oncol. 2017;1.
Title:	Integration of pharmacology, molecular pathology, and population data science to support precision gastrointestinal oncology.
Author:	Ogino, Shuji\|Jhun, Iny\|Mata, Douglas A\|Soong, Thing Rinda\|Hamada, Tsuyoshi\|Liu, Li\|Nishihara, Reiko\|Giannakis, Marios\|Cao, Yin\|Manson, JoAnn E\|Nowak, Jonathan A\|Chan, Andrew T
PMID:	29552640

122.
Journal:	Appl Immunohistochem Mol Morphol. 2018 Jul;26(6):393-397.
Title:	PD-L1 Expression in Carcinosarcomas of the Gynecologic Tract: A Potentially Actionable Biomarker.
Author:	Pinto, Andre\|Mackrides, Nicholas\|Nadji, Mehrdad
PMID:	27801734

123.
Journal:	Curr Cancer Drug Targets. 2018;18(5):421-429.
Title:	Metastatic Colorectal Cancer: Role of Target Therapies and Future Perspectives.
Author:	Nappi, Anna\|Berretta, Massimiliano\|Romano, Carmela\|Tafuto, Salvatore\|Cassata, Antonino\|Casaretti, Rossana\|Silvestro, Lucrezia\|Divitiis, Chiara De\|Alessandrini, Lara\|Fiorica, Francesco\|Ottaiano, Alessandro\|Nasti, Guglielmo
PMID:	28183254

124.
Journal:	J Clin Pathol. 2018 Jan;71(1):46-51.
Title:	PD-L1 protein expression in tumour cells and immune cells in mismatch repair protein-deficient and -proficient colorectal cancer: the foundation study using the SP142 antibody and whole section immunohistochemistry.
Author:	El Jabbour, Tony\|Ross, Jeffrey S\|Sheehan, Christine E\|Affolter, Kajsa E\|Geiersbach, Katherine B\|Boguniewicz, Ann\|Ainechi, Sanaz\|Bronner, Mary P\|Jones, David M\|Lee, Hwajeong
PMID:	28667193

125.
Journal:	J Natl Cancer Inst. 2018 Jan 1;110(1). pii: 4093940.
Title:	The Balance Between Cytotoxic T-cell Lymphocytes and Immune Checkpoint Expression in the Prognosis of Colon Tumors.
Author:	Marisa, Laetitia\|Svrcek, Magali\|Collura, Ada\|Becht, Etienne\|Cervera, Pascale\|Wanherdrick, Kristell\|Buhard, Olivier\|Goloudina, Anastasia\|Jonchere, Vincent\|Selves, Janick\|Milano, Gerard\|Guenot, Dominique\|Cohen, Romain\|Colas, Chrystelle\|Laurent-Puig, Pierre\|
PMID:	28922790

126.
Journal:	Hum Vaccin Immunother. 2018 Jan 2;14(1):140-145.
Title:	Sequential administration of MVA-based vaccines and PD-1/PD-L1-blocking antibodies confers measurable benefits on tumor growth and survival: Preclinical studies with MVA-betaGal and MVA-MUC1 (TG4010) in a murine tumor model.
Author:	Remy-Ziller, Christelle\|Thioudellet, Christine\|Hortelano, Julie\|Gantzer, Murielle\|Nourtier, Virginie\|Claudepierre, Marie-Christine\|Sansas, Benoit\|Preville, Xavier\|Bendjama, Kaidre\|Quemeneur, Eric\|Rittner, Karola
PMID:	28925793

127.
Journal:	Histopathology. 2018 Mar;72(4):697-703.
Title:	A novel histological examination with dynamic three-dimensional reconstruction from multiple immunohistochemically stained sections of a PD-L1-positive colon cancer.
Author:	Korehisa, Shotaro\|Ikeda, Tetsuo\|Okano, Shinji\|Saeki, Hiroshi\|Oki, Eiji\|Oda, Yoshinao\|Hashizume, Makoto\|Maehara, Yoshihiko
PMID:	28940664

128.
Journal:	Int J Cancer. 2018 Feb 15;142(4):822-832.
Title:	Clinical significance of programmed cell death-ligand 1 expression and the immune microenvironment at the invasive front of colorectal cancers with high microsatellite instability.
Author:	Korehisa, Shotaro\|Oki, Eiji\|Iimori, Makoto\|Nakaji, Yu\|Shimokawa, Mototsugu\|Saeki, Hiroshi\|Okano, Shinji\|Oda, Yoshinao\|Maehara, Yoshihiko
PMID:	29044503

129.
Journal:	Int J Oncol. 2018 Jan;52(1):127-138.
Title:	Ginsenoside Rg3 targets cancer stem cells and tumor angiogenesis to inhibit colorectal cancer progression in vivo.
Author:	Tang, Yu-Chen\|Zhang, Yan\|Zhou, Jin\|Zhi, Qiaoming\|Wu, Meng-Yao\|Gong, Fei-Ran\|Shen, Meng\|Liu, Lu\|Tao, Min\|Shen, Bairong\|Gu, Dong-Mei\|Yu, Jie\|Xu, Meng-Dan\|Gao, Yuan\|Li, Wei
PMID:	29115601

130.
Journal:	Arch Pathol Lab Med. 2018 Jan;142(1):26-34.
Title:	Is There a Role for Programmed Death Ligand-1 Testing and Immunotherapy in Colorectal Cancer With Microsatellite Instability? Part II-The Challenge of Programmed Death Ligand-1 Testing and Its Role in Microsatellite Instability-High Colorectal Cancer.
Author:	Marginean, Esmeralda Celia\|Melosky, Barbara
PMID:	29120224

131.
Journal:	Cancer Immunol Res. 2018 Jan;6(1):59-68.
Title:	Soluble CD80 Protein Delays Tumor Growth and Promotes Tumor-Infiltrating Lymphocytes.
Author:	Horn, Lucas A\|Long, Tiha M\|Atkinson, Ryan\|Clements, Virginia\|Ostrand-Rosenberg, Suzanne
PMID:	29122838

132.
Journal:	Mod Pathol. 2018 Feb;31(2):214-234.
Title:	Implications of the tumor immune microenvironment for staging and therapeutics.
Author:	Taube, Janis M\|Galon, Jerome\|Sholl, Lynette M\|Rodig, Scott J\|Cottrell, Tricia R\|Giraldo, Nicolas A\|Baras, Alexander S\|Patel, Sanjay S\|Anders, Robert A\|Rimm, David L\|Cimino-Mathews, Ashley
PMID:	29192647

133.
Journal:	Scand J Immunol. 2018 Feb;87(2):63-72.
Title:	MUC1- and Survivin-based DNA Vaccine Combining Immunoadjuvants CpG and interleukin-2 in a Bicistronic Expression Plasmid Generates Specific Immune Responses and Antitumour Effects in a Murine Colorectal Carcinoma Model.
Author:	Liu, C\|Xie, Y\|Sun, B\|Geng, F\|Zhang, F\|Guo, Q\|Wu, H\|Yu, B\|Wu, J\|Yu, X\|Kong, W\|Zhang, H
PMID:	29193199

134.
Journal:	Hum Pathol. 2018 Feb;72:135-143.
Title:	Mismatch repair-deficient colorectal cancer: a model of immunogenic and immune cell-rich tumor despite nonsignificant programmed cell death ligand-1 expression in tumor cells.
Author:	Le Flahec, Glen\|Badic, Bogdan\|Guibourg, Briac\|Doucet, Laurent\|Bail, Jean-Pierre\|Marcorelles, Pascale\|Schick, Ulrike\|Uguen, Arnaud
PMID:	29208565

135.
Journal:	Cancer Treat Rev. 2018 Feb;63:48-60.
Title:	Rationale for combination of therapeutic antibodies targeting tumor cells and immune checkpoint receptors: Harnessing innate and adaptive immunity through IgG1 isotype immune effector stimulation.
Author:	Ferris, Robert L\|Lenz, Heinz-Josef\|Trotta, Anna Maria\|Garcia-Foncillas, Jesus\|Schulten, Jeltje\|Audhuy, Francois\|Merlano, Marco\|Milano, Gerard
PMID:	29223828

136.
Journal:	Nat Commun. 2018 Jan 2;9(1):32.
Title:	Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution.
Author:	Efremova, Mirjana\|Rieder, Dietmar\|Klepsch, Victoria\|Charoentong, Pornpimol\|Finotello, Francesca\|Hackl, Hubert\|Hermann-Kleiter, Natascha\|Lower, Martin\|Baier, Gottfried\|Krogsdam, Anne\|Trajanoski, Zlatko
PMID:	29296022

137.
Journal:	Oncoimmunology. 2017 Nov 6;7(2):e1390640.
Title:	High numbers of PDCD1 (PD-1)-positive T cells and B2M mutations in microsatellite-unstable colorectal cancer.
Author:	Janikovits, Jonas\|Muller, Meike\|Krzykalla, Julia\|Korner, Sandrina\|Echterdiek, Fabian\|Lahrmann, Bernd\|Grabe, Niels\|Schneider, Martin\|Benner, Axel\|Doeberitz, Magnus von Knebel\|Kloor, Matthias
PMID:	29308317

138.
Journal:	Int J Clin Oncol. 2018 Jun;23(3):504-513.
Title:	Differences in histological features and PD-L1 expression between sporadic microsatellite instability and Lynch-syndrome-associated disease in Japanese patients with colorectal cancer.
Author:	Yamada, Rin\|Yamaguchi, Tatsuro\|Iijima, Takeru\|Wakaume, Rika\|Takao, Misato\|Koizumi, Koichi\|Hishima, Tsunekazu\|Horiguchi, Shin-Ichiro
PMID:	29327160

139.
Journal:	Eur J Cancer. 2018 Mar;91:11-20.
Title:	Pattern of programmed cell death-ligand 1 expression and CD8-positive T-cell infiltration before and after chemoradiotherapy in rectal cancer.
Author:	Ogura, Atsushi\|Akiyoshi, Takashi\|Yamamoto, Noriko\|Kawachi, Hiroshi\|Ishikawa, Yuichi\|Mori, Seiichi\|Oba, Koji\|Nagino, Masato\|Fukunaga, Yosuke\|Ueno, Masashi
PMID:	29328976

140.
Journal:	PLoS One. 2018 Feb 6;13(2):e0192385.
Title:	Investigation of single and synergic effects of NLRC5 and PD-L1 variants on the risk of colorectal cancer.
Author:	Catalano, Calogerina\|da Silva Filho, Miguel Inacio\|Frank, Christoph\|Jiraskova, Katerina\|Vymetalkova, Veronika\|Levy, Miroslav\|Liska, Vaclav\|Vycital, Ondrej\|Naccarati, Alessio\|Vodickova, Ludmila\|Hemminki, Kari\|Vodicka, Pavel\|Weber, Alexander N R\|Forsti, Ast
PMID:	29408916

141.
Journal:	Gut. 2018 Jun;67(6):1168-1180.
Title:	Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine.
Author:	Ogino, Shuji\|Nowak, Jonathan A\|Hamada, Tsuyoshi\|Phipps, Amanda I\|Peters, Ulrike\|Milner, Danny A Jr\|Giovannucci, Edward L\|Nishihara, Reiko\|Giannakis, Marios\|Garrett, Wendy S\|Song, Mingyang
PMID:	29437869

142.
Journal:	Nature. 2018 Feb 22;554(7693):538-543.
Title:	TGFbeta drives immune evasion in genetically reconstituted colon cancer metastasis.
Author:	Tauriello, Daniele V F\|Palomo-Ponce, Sergio\|Stork, Diana\|Berenguer-Llergo, Antonio\|Badia-Ramentol, Jordi\|Iglesias, Mar\|Sevillano, Marta\|Ibiza, Sales\|Canellas, Adria\|Hernando-Momblona, Xavier\|Byrom, Daniel\|Matarin, Joan A\|Calon, Alexandre\|Rivas, Elisa I\|Ne
PMID:	29443964

143.
Journal:	Expert Opin Biol Ther. 2018 May;18(5):561-573.
Title:	Results and challenges of immune checkpoint inhibitors in colorectal cancer.
Author:	Emambux, Sheik\|Tachon, Gaelle\|Junca, Audelaure\|Tougeron, David
PMID:	29471676

144.
Journal:	Expert Opin Biol Ther. 2018 Apr;18(4):449-457.
Title:	Atezolizumab for the treatment of colorectal cancer: the latest evidence and clinical potential.
Author:	Tapia Rico, Gonzalo\|Price, Timothy J
PMID:	29471699

145.
Journal:	Oncotarget. 2018 Jan 12;9(9):8584-8596.
Title:	PD-L1 expression in colorectal cancer defines three subsets of tumor immune microenvironments.
Author:	Valentini, Anna Maria\|Di Pinto, Federica\|Cariola, Filomena\|Guerra, Vito\|Giannelli, Gianluigi\|Caruso, Maria Lucia\|Pirrelli, Michele
PMID:	29492219

146.
Journal:	J Cancer Res Clin Oncol. 2018 Jun;144(6):1005-1014.
Title:	CD274, LAG3, and IDO1 expressions in tumor-infiltrating immune cells as prognostic biomarker for patients with MSI-high colon cancer.
Author:	Lee, Soo Jung\|Jun, Sun-Young\|Lee, In Hee\|Kang, Byung Woog\|Park, Su Yeon\|Kim, Hye Jin\|Park, Jun Seok\|Choi, Gyu-Seog\|Yoon, Ghilsuk\|Kim, Jong Gwang
PMID:	29520442

147.
Journal:	Future Oncol. 2018 Apr;14(10):947-962.
Title:	Upper gastrointestinal malignancies in 2017: current perspectives and future approaches.
Author:	Solomon, Benjamin L\|Garrido-Laguna, Ignacio
PMID:	29542354

148.
Journal:	Oncol Lett. 2018 Apr;15(4):5345-5351.
Title:	Improving immunotherapy for colorectal cancer using dendritic cells combined with anti-programmed death-ligand in vitro.
Author:	Hu, Zilong\|Ma, Yue\|Shang, Zhiyang\|Hu, Shidong\|Liang, Kai\|Liang, Wentao\|Xing, Xiaowei\|Wang, Yufeng\|Du, Xiaohui
PMID:	29552177

149.
Journal:	Anticancer Res. 2018 Apr;38(4):2235-2240.
Title:	Racial Disparities in the Molecular Landscape of Cancer.
Author:	Heath, Elisabeth I\|Lynce, Filipa\|Xiu, Joanne\|Ellerbrock, Angela\|Reddy, Sandeep K\|Obeid, Elias\|Liu, Stephen V\|Bollig-Fischer, Aliccia\|Separovic, Duska\|Vanderwalde, Ari
PMID:	29599344

150.
Journal:	Oncoimmunology. 2018 Feb 12;7(4):e1395123.
Title:	Activated human primary NK cells efficiently kill colorectal cancer cells in 3D spheroid cultures irrespectively of the level of PD-L1 expression.
Author:	Lanuza, Pilar M\|Vigueras, Alan\|Olivan, Sara\|Prats, Anne C\|Costas, Santiago\|Llamazares, Guillermo\|Sanchez-Martinez, Diego\|Ayuso, Jose Maria\|Fernandez, Luis\|Ochoa, Ignacio\|Pardo, Julian
PMID:	29632716

151.
Journal:	Biomed Res Int. 2018 Jan 31;2018:5920608.
Title:	Prognostic Value of Immunoscore and PD-L1 Expression in Metastatic Colorectal Cancer Patients with Different RAS Status after Palliative Operation.
Author:	Liu, Ruiqi\|Peng, Ke\|Yu, Yiyi\|Liang, Li\|Xu, Xiaojing\|Li, Wei\|Yu, Shan\|Liu, Tianshu
PMID:	29662888

152.
Journal:	J Surg Oncol. 2018 Jun;117(7):1405-1412.
Title:	Transition of the programmed death 1 pathway from the primary colorectal cancer to its corresponding pulmonary metastasis.
Author:	Miyamoto, Ei\|Chen-Yoshikawa, Toyofumi F\|Ueshima, Chiyuki\|Yoshizawa, Akihiko\|Hamaji, Masatsugu\|Yamamoto, Takamasa\|Kawada, Kenji\|Haga, Hironori\|Sakai, Yoshiharu\|Date, Hiroshi
PMID:	29663398

153.
Journal:	Oncol Res Treat. 2018;41(5):282-285.
Title:	Immunotherapy of Colon Cancer.
Author:	Stein, Alexander\|Folprecht, Gunnar
PMID:	29705788

154.
Journal:	JAMA Oncol. 2018 Aug 1;4(8):1085-1092.
Title:	Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome.
Author:	Chang, Kyle\|Taggart, Melissa W\|Reyes-Uribe, Laura\|Borras, Ester\|Riquelme, Erick\|Barnett, Reagan M\|Leoni, Guido\|San Lucas, F Anthony\|Catanese, Maria T\|Mori, Federica\|Diodoro, Maria G\|You, Y Nancy\|Hawk, Ernest T\|Roszik, Jason\|Scheet, Paul\|Kopetz, Scott\|Nico
PMID:	29710228

155.
Journal:	Oncoimmunology. 2018 Feb 14;7(5):e1426519.
Title:	M7824, a novel bifunctional anti-PD-L1/TGFbeta Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine.
Author:	Knudson, Karin M\|Hicks, Kristin C\|Luo, Xiaoling\|Chen, Jin-Qiu\|Schlom, Jeffrey\|Gameiro, Sofia R
PMID:	29721396

156.
Journal:	Medicine (Baltimore). 2018 May;97(19):e0718.
Title:	Immunotherapy for pulmonary squamous cell carcinoma and colon carcinoma with pembrolizumab: A case report.
Author:	Nozawa, Yoshihiro\|Oka, Yuka\|Oosugi, Jun\|Takemura, Shinichi
PMID:	29742733

157.
Journal:	Ann Surg Oncol. 2018 Aug;25(8):2323-2331.
Title:	Cytolytic Activity Score to Assess Anticancer Immunity in Colorectal Cancer.
Author:	Narayanan, Sumana\|Kawaguchi, Tsutomu\|Yan, Li\|Peng, Xuan\|Qi, Qianya\|Takabe, Kazuaki
PMID:	29770915

158.
Journal:	Anticancer Res. 2018 Jun;38(6):3367-3373.
Title:	Programmed Cell Death Ligand 1 Expression Is an Independent Prognostic Factor in Colorectal Cancer.
Author:	Enkhbat, Tumenjin\|Nishi, Masaaki\|Takasu, Chie\|Yoshikawa, Kozo\|Jun, Higashijima\|Tokunaga, Takuya\|Kashihara, Hideya\|Ishikawa, Daichi\|Shimada, Mitsuo
PMID:	29848685

159.
Journal:	J Immunol Res. 2018 May 8;2018:9485285.
Title:	PD-L1 Expression Predicts a Distinct Prognosis in Krukenberg Tumor with Corresponding Origins.
Author:	Tai, Haiyan\|Yang, Qin\|Wu, Zhiyong\|Sun, Su'an\|Cao, Rui\|Xi, Yanfeng\|Zhao, Ran\|Zhang, Mengyu\|Zhang, Zhigang\|Xu, Congjian
PMID:	29854854

160.
Journal:	Chin J Cancer Res. 2018 Apr;30(2):197-208.
Title:	Impact of 5-Fu/oxaliplatin on mouse dendritic cells and synergetic effect with a colon cancer vaccine.
Author:	Hong, Xinqiang\|Dong, Tiangeng\|Yi, Tuo\|Hu, Jianwei\|Zhang, Zhen\|Lin, Shengli\|Niu, Weixin
PMID:	29861605

161.
Journal:	J Immunother Cancer. 2018 Jun 4;6(1):47.
Title:	Targeting the TGFbeta pathway with galunisertib, a TGFbetaRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade.
Author:	Holmgaard, Rikke B\|Schaer, David A\|Li, Yanxia\|Castaneda, Stephen P\|Murphy, Mary Y\|Xu, Xiaohong\|Inigo, Ivan\|Dobkin, Julie\|Manro, Jason R\|Iversen, Philip W\|Surguladze, David\|Hall, Gerald E\|Novosiadly, Ruslan D\|Benhadji, Karim A\|Plowman, Gregory D\|Kalos, Mic
PMID:	29866156

162.
Journal:	Oncoimmunology. 2018 Feb 14;7(6):e1431088.
Title:	RANKL blockade improves efficacy of PD1-PD-L1 blockade or dual PD1-PD-L1 and CTLA4 blockade in mouse models of cancer.
Author:	Ahern, Elizabeth\|Harjunpaa, Heidi\|O'Donnell, Jake S\|Allen, Stacey\|Dougall, William C\|Teng, Michele W L\|Smyth, Mark J
PMID:	29872559

163.
Journal:	Oncoimmunology. 2018 Mar 15;7(6):e1433981.
Title:	PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer.
Author:	Dosset, Magalie\|Vargas, Thaiz Rivera\|Lagrange, Anais\|Boidot, Romain\|Vegran, Frederique\|Roussey, Aurelie\|Chalmin, Fanny\|Dondaine, Lucile\|Paul, Catherine\|Lauret Marie-Joseph, Elodie\|Martin, Francois\|Ryffel, Bernhard\|Borg, Christophe\|Adotevi, Olivier\|Ghiring
PMID:	29872568

164.
Journal:	Oncoimmunology. 2018 Feb 22;7(6):e1435227.
Title:	Potential immune priming of the tumor microenvironment with FOLFOX chemotherapy in locally advanced rectal cancer.
Author:	Roxburgh, Campbell S\|Shia, Jinru\|Vakiani, Efsevia\|Daniel, Tanisha\|Weiser, Martin R
PMID:	29872576

165.
Journal:	Nat Commun. 2018 Jun 8;9(1):2237.
Title:	Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap.
Author:	Song, Wantong\|Shen, Limei\|Wang, Ying\|Liu, Qi\|Goodwin, Tyler J\|Li, Jingjing\|Dorosheva, Olekasandra\|Liu, Tianzhou\|Liu, Rihe\|Huang, Leaf
PMID:	29884866

166.
Journal:	Oncoimmunology. 2018 Mar 19;7(7):e1442999.
Title:	TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor CD274 (PD-L1) expression status and tumor-infiltrating lymphocytes in colorectal carcinomas.
Author:	Hamada, Tsuyoshi\|Soong, Thing Rinda\|Masugi, Yohei\|Kosumi, Keisuke\|Nowak, Jonathan A\|da Silva, Annacarolina\|Mu, Xinmeng Jasmine\|Twombly, Tyler S\|Koh, Hideo\|Yang, Juhong\|Song, Mingyang\|Liu, Li\|Gu, Mancang\|Shi, Yan\|Nosho, Katsuhiko\|Morikawa, Teppei\|Inamura,
PMID:	29900052

167.
Journal:	Oncoimmunology. 2018 Apr 25;7(7):e1448332.
Title:	Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer.
Author:	Zhou, Guoying\|Noordam, Lisanne\|Sprengers, Dave\|Doukas, Michail\|Boor, Patrick P C\|van Beek, Adriaan A\|Erkens, Remco\|Mancham, Shanta\|Grunhagen, Dirk\|Menon, Anand G\|Lange, Johan F\|Burger, Pim J W A\|Brandt, Alexandra\|Galjart, Boris\|Verhoef, Cornelis\|Kwekkeboo
PMID:	29900067

168.
Journal:	Nat Immunol. 2018 Jun 18. pii: 10.1038/s41590-018-0132-0.
Title:	Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity.
Author:	Zhang, Qing\|Bi, Jiacheng\|Zheng, Xiaodong\|Chen, Yongyan\|Wang, Hua\|Wu, Wenyong\|Wang, Zhengguang\|Wu, Qiang\|Peng, Hui\|Wei, Haiming\|Sun, Rui\|Tian, Zhigang
PMID:	29915296

169.
Journal:	Cancer Sci. 2018 Sep;109(9):2957-2969.
Title:	Programmed cell death ligand-1 protein expression and CD274/PD-L1 gene amplification in colorectal cancer: Implications for prognosis.
Author:	Lee, Kyu Sang\|Kim, Bo Hyung\|Oh, Heung-Kwon\|Kim, Duck-Woo\|Kang, Sung-Bum\|Kim, Hyunchul\|Shin, Eun
PMID:	29949671

170.
Journal:	Cell Death Dis. 2018 Jul 10;9(7):766.
Title:	CCL5-deficiency enhances intratumoral infiltration of CD8(+) T cells in colorectal cancer.
Author:	Zhang, Shengbo\|Zhong, Ming\|Wang, Chao\|Xu, Yanjie\|Gao, Wei-Qiang\|Zhang, Yan
PMID:	29991744

171.
Journal:	Clin Cancer Res. 2018 Jul 26. pii: 1078-0432.CCR-18-0330.
Title:	Blocking monocytic myeloid-derived suppressor cell function via anti-DC-HIL/GPNMB antibody restores the in vitro integrity of T-cells from cancer patients.
Author:	Kobayashi, Masato\|Chung, Jin-Sung\|Beg, Muhammad\|Arriaga, Yull\|Verma, Udit N\|Courtney, Kevin\|Mansour, John C\|Haley, Barbara\|Khan, Saad A\|Horiuchi, Yutaka\|Ramani, Vijay\|Harker, David\|Gopal, Purva\|Araghizadeh, Farshid\|Cruz, Ponciano D\|Ariizumi, Kiyoshi
PMID:	30049749

172.
Journal:	Pharm Res. 2018 Jul 30;35(9):183.
Title:	(-)-4-O-(4-O-beta-D-glucopyranosylcaffeoyl) Quinic Acid Inhibits the Function of Myeloid-Derived Suppressor Cells to Enhance the Efficacy of Anti-PD1 against Colon Cancer.
Author:	Lin, HongYue\|Wu, YuZhu\|Chen, JinPing\|Huang, ShuRong\|Wang, YangQiang
PMID:	30062658

173.
Journal:	Int J Oncol. 2018 Oct;53(4):1469-1480.
Title:	Upregulation of PDL1 expression by resveratrol and piceatannol in breast and colorectal cancer cells occurs via HDAC3/p300mediated NFkappaB signaling.
Author:	Lucas, Justin\|Hsieh, Tze-Chen\|Halicka, H Dorota\|Darzynkiewicz, Zbigniew\|Wu, Joseph M
PMID:	30066852

174.
Journal:	Clin Epigenetics. 2018 Aug 6;10(1):104.
Title:	DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer.
Author:	Sasidharan Nair, Varun\|Toor, Salman M\|Taha, Rowaida Z\|Shaath, Hibah\|Elkord, Eyad
PMID:	30081950

175.
Journal:	Med Sci Monit. 2018 Aug 8;24:5501-5508.
Title:	Targeting Interleukin-6 (IL-6) Sensitizes Anti-PD-L1 Treatment in a Colorectal Cancer Preclinical Model.
Author:	Li, Jibin\|Xu, Jian\|Yan, Xiaofei\|Jin, Keer\|Li, Wenya\|Zhang, Rui
PMID:	30087314

176.
Journal:	Cancer Immunol Immunother. 2018 Aug 20. pii: 10.1007/s00262-018-2227-8.
Title:	Expression of the inhibitory B7 family molecule VISTA in human colorectal carcinoma tumors.
Author:	Xie, Shan\|Huang, Jia\|Qiao, Qin\|Zang, Wenjuan\|Hong, Shanjuan\|Tan, Haidong\|Dong, Chen\|Yang, Zhiying\|Ni, Ling
PMID:	30128738

177.
Journal:	BMC Cancer. 2018 Aug 24;18(1):848.
Title:	ALDH1A3 upregulation and spontaneous metastasis formation is associated with acquired chemoresistance in colorectal cancer cells.
Author:	Durinikova, Erika\|Kozovska, Zuzana\|Poturnajova, Martina\|Plava, Jana\|Cierna, Zuzana\|Babelova, Andrea\|Bohovic, Roman\|Schmidtova, Silvia\|Tomas, Miroslav\|Kucerova, Lucia\|Matuskova, Miroslava
PMID:	30143021

178.
Journal:	J Gastrointest Oncol. 2018 Aug;9(4):610-617.
Title:	Beyond microsatellite testing: assessment of tumor mutational burden identifies subsets of colorectal cancer who may respond to immune checkpoint inhibition.
Author:	Fabrizio, David A\|George, Thomas J Jr\|Dunne, Richard F\|Frampton, Garrett\|Sun, James\|Gowen, Kyle\|Kennedy, Mark\|Greenbowe, Joel\|Schrock, Alexa B\|Hezel, Aram F\|Ross, Jeffrey S\|Stephens, Phillip J\|Ali, Siraj M\|Miller, Vincent A\|Fakih, Marwan\|Klempner, Samuel
PMID:	30151257

179.
Journal:	Adv Exp Med Biol. 2018;1060:115-129.
Title:	Immunosuppression by Intestinal Stromal Cells.
Author:	Pinchuk, Iryna V\|Powell, Don W
PMID:	30155625

180.
Journal:	Nanoscale. 2018 Sep 13;10(35):16738-16749.
Title:	EGFR-targeted liposomal nanohybrid cerasomes: theranostic function and immune checkpoint inhibition in a mouse model of colorectal cancer.
Author:	Li, Yuan\|Du, Yang\|Liang, Xiaolong\|Sun, Ting\|Xue, Huadan\|Tian, Jie\|Jin, Zhengyu
PMID:	30156250

181.
Journal:	Gan To Kagaku Ryoho. 2018 Aug;45(8):1159-1163.
Title:	[Selection of Chemotherapy Regimen on the Basis of Monitoring NLR and Soluble PD-L1 during CRC Chemotherapy].
Author:	Muneoka, Katsuki\|Shirai, Yoshio\|Sasaki, Masataka\|Honma, Shinsuke\|Sakata, Jun\|Kanda, Junkichi\|Wakabayashi, Hiroyuki\|Wakai, Toshifumi\|Miyazaki, Makoto
PMID:	30158411

182.
Journal:	Clin Exp Pharmacol Physiol. 2018 Aug 30.
Title:	The roles of PD-1/PD-L1 and its signalling pathway in gastrointestinal tract cancers.
Author:	Cui, Chunguo\|Yu, Bo\|Jiang, Qi\|Li, Xingfang\|Shi, Kaiyao\|Yang, Zecheng
PMID:	30161295

183.
Journal:	Mod Pathol. 2018 Aug 30. pii: 10.1038/s41379-018-0114-7.
Title:	Cellular localization of PD-L1 expression in mismatch-repair-deficient and proficient colorectal carcinomas.
Author:	Liu, Sandy\|Gnen, Mithat\|Stadler, Zsofia K\|Weiser, Martin R\|Hechtman, Jaclyn F\|Vakiani, Efsevia\|Wang, Tao\|Vyas, Monika\|Joneja, Upasana\|Al-Bayati, Moataz\|Segal, Neil H\|Smith, J Joshua\|King, Sarah\|Guercio, Shanna\|Ntiamoah, Peter\|Markowitz, Arnold J\|Zhang, Li
PMID:	30166615

184.
Journal:	Hum Pathol. 2018 Aug 30. pii: S0046-8177(18)30336-8.
Title:	Immune environment in serrated lesions of the Colon: intraepithelial lymphocyte density, PD-1, and PD-L1 expression correlate with serrated neoplasia pathway progression.
Author:	Acosta-Gonzalez, Gabriel\|Ouseph, Madhu\|Lombardo, Kara\|Lu, Shaolei\|Glickman, Jonathan\|Resnick, Murray
PMID:	30172913

185.
Journal:	Crit Rev Oncol Hematol. 2018 Oct;130:13-26.
Title:	Immuno-oncology in GI tumours: Clinical evidence and emerging trials of PD-1/PD-L1 antagonists.
Author:	Stein, Alexander\|Markus, Moehler\|Jorg, Trojan\|Eray, Goekkurt\|Vogel, Arndt
PMID:	30196908

186.
Journal:	Cancer Cell Int. 2018 Sep 6;18:131.
Title:	Assessment of intratumor immune-microenvironment in colorectal cancers with extranodal extension of nodal metastases.
Author:	Fassan, Matteo\|Vianello, Luca\|Sacchi, Diana\|Fanelli, Giuseppe N\|Munari, Giada\|Scarpa, Marco\|Cappellesso, Rocco\|Loupakis, Fotios\|Lanza, Cristiano\|Salmaso, Roberta\|Mescoli, Claudia\|Valeri, Nicola\|Agostini, Marco\|D'Angelo, Edoardo\|Lonardi, Sara\|Pucciarelli,
PMID:	30202242

187.
Journal:	Exp Cell Res. 2018 Nov 1;372(1):35-42.
Title:	Follicular helper T cells promote the effector functions of CD8(+) T cells via the provision of IL-21, which is downregulated due to PD-1/PD-L1-mediated suppression in colorectal cancer.
Author:	Shi, Weiwei\|Dong, Lin\|Sun, Qiong\|Ding, Hong\|Meng, Jing\|Dai, Guanghai
PMID:	30205088

188.
Journal:	Mod Pathol. 2018 Sep 11. pii: 10.1038/s41379-018-0124-5.
Title:	Low miR200c expression in tumor budding of invasive front predicts worse survival in patients with localized colon cancer and is related to PD-L1 overexpression.
Author:	Martinez-Ciarpaglini, Carolina\|Oltra, Sara\|Rosello, Susana\|Roda, Desamparados\|Mongort, Cristina\|Carrasco, Francisca\|Gonzalez, Jose\|Santonja, Francisco\|Tarazona, Noelia\|Huerta, Marisol\|Espi, Alejandro\|Ribas, Gloria\|Ferrandez, Antonio\|Navarro, Samuel\|Cervan
PMID:	30206410

189.
Journal:	Oncoimmunology. 2018 Apr 9;7(8):e1450711.
Title:	Intratumoral injection of activated B lymphoblast in combination with PD-1 blockade induces systemic antitumor immunity with reduction of local and distal tumors.
Author:	Soldevilla, Mario M\|Villanueva, Helena\|Martinez-Velez, Naiara\|Meraviglia-Crivelli, Daniel\|Alonso, Marta M\|Cebollero, Javier\|Menon, Ashwathi P\|Puigdelloses, Montserrat\|Pastor, Fernando
PMID:	30221041

190.
Journal:	Oncoimmunology. 2018 Jun 11;7(8):e1465165.
Title:	Expression of programmed cell death protein 1 (PD-1) and its ligand PD-L1 in colorectal cancer: Relationship with sidedness and prognosis.
Author:	Berntsson, Jonna\|Eberhard, Jakob\|Nodin, Bjorn\|Leandersson, Karin\|Larsson, Anna H\|Jirstrom, Karin
PMID:	30221062

191.
Journal:	Cancer Immunol Res. 2018 Sep 18. pii: 2326-6066.CIR-17-0443.
Title:	Stromal cell PD-L1 inhibits CD8+ T-cell antitumor immune responses and promotes colon cancer.
Author:	O'Malley, Grace\|Treacy, Oliver\|Lynch, Kevin\|Naicker, Serika D\|Leonard, Niamh A\|Lohan, Paul\|Dunne, Philip D\|Ritter, Thomas\|Egan, Laurence John\|Ryan, Aideen E
PMID:	30228206

192.
Journal:	Oncol Lett. 2018 Oct;16(4):5214-5222.
Title:	Prognostic impact of programmed cell death ligand 1 expression on long-term oncologic outcomes in colorectal cancer.
Author:	Bae, Sung Uk\|Jeong, Woon Kyung\|Baek, Seong Kyu\|Kim, Nam Kyu\|Hwang, Ilseon
PMID:	30250590

193.
Journal:	Cancer Manag Res. 2018 Sep 17;10:3569-3577.
Title:	Low tumor purity is associated with poor prognosis, heavy mutation burden, and intense immune phenotype in colon cancer.
Author:	Mao, Yihao\|Feng, Qingyang\|Zheng, Peng\|Yang, Liangliang\|Liu, Tianyu\|Xu, Yuqiu\|Zhu, Dexiang\|Chang, Wenju\|Ji, Meiling\|Ren, Li\|Wei, Ye\|He, Guodong\|Xu, Jianmin
PMID:	30271205

194.
Journal:	Oncol Rep. 2018 Sep 26.
Title:	Antitumor effects of the silencing of programmed cell death ligand 1 in colorectal cancer via immunoregulation.
Author:	Chen, Yilin\|Huang, Ying\|Lu, Xingrong\|Wang, Gaoxiong\|Chi, Pan
PMID:	30272332

195.
Journal:	Cancer Immunol Res. 2018 Nov;6(11):1401-1416.
Title:	Somatic Mutations and Immune Alternation in Rectal Cancer Following Neoadjuvant Chemoradiotherapy.
Author:	Ji, Dengbo\|Yi, Haizhao\|Zhang, Dakui\|Zhan, Tiancheng\|Li, Zhaowei\|Li, Ming\|Jia, Jinying\|Qiao, Meng\|Xia, Jinhong\|Zhai, Zhiwei\|Song, Can\|Gu, Jin
PMID:	30282671

196.
Journal:	BMC Cancer. 2018 Oct 3;18(1):945.
Title:	PD-L1/PD-1 crosstalk in colorectal cancer: are we targeting the right cells?
Author:	Cantero-Cid, Ramon\|Casas-Martin, Jose\|Hernandez-Jimenez, Enrique\|Cubillos-Zapata, Carolina\|Varela-Serrano, Anibal\|Avendano-Ortiz, Jose\|Casarrubios, Marta\|Montalban-Hernandez, Karla\|Villacanas-Gil, Ignacio\|Guerra-Pastrian, Laura\|Peinado, Begona\|Marcano, Cr
PMID:	30285662

197.
Journal:	Oncoimmunology. 2018 Jul 11;7(10):e1488566.
Title:	The comprehensive molecular landscape of the immunologic co-stimulator B7 and TNFR ligand receptor families in colorectal cancer: immunotherapeutic implications with microsatellite instability.
Author:	Tang, Jinghua\|Jiang, Wu\|Liu, Dingxin\|Luo, Jun\|Wu, Xiaodan\|Pan, Zhizhong\|Ding, Peirong\|Li, Yingqin
PMID:	30288357

198.
Journal:	Cancer Immunol Immunother. 2018 Oct 12. pii: 10.1007/s00262-018-2259-0.
Title:	Association of IL-36gamma with tertiary lymphoid structures and inflammatory immune infiltrates in human colorectal cancer.
Author:	Weinstein, Aliyah M\|Giraldo, Nicolas A\|Petitprez, Florent\|Julie, Catherine\|Lacroix, Laetitia\|Peschaud, Frederique\|Emile, Jean-Francois\|Marisa, Laetitia\|Fridman, Wolf H\|Storkus, Walter J\|Sautes-Fridman, Catherine
PMID:	30315348

199.
Journal:	Cancer Immunol Immunother. 2018 Oct 12. pii: 10.1007/s00262-018-2253-6.
Title:	Histamine targets myeloid-derived suppressor cells and improves the anti-tumor efficacy of PD-1/PD-L1 checkpoint blockade.
Author:	Grauers Wiktorin, Hanna\|Nilsson, Malin S\|Kiffin, Roberta\|Sander, Frida Ewald\|Lenox, Brianna\|Rydstrom, Anna\|Hellstrand, Kristoffer\|Martner, Anna
PMID:	30315349

200.
Journal:	Sci Rep. 2018 Oct 23;8(1):15658.
Title:	Clinical significance of programmed death 1 ligand-1 (CD274/PD-L1) and intra-tumoral CD8+ T-cell infiltration in stage II-III colorectal cancer.
Author:	Huang, Chih-Yang\|Chiang, Shu-Fen\|Ke, Tao-Wei\|Chen, Tsung-Wei\|You, Ying-Shu\|Chen, William Tzu-Liang\|Chao, K S Clifford
PMID:	30353144

201.
Journal:	Clin Cancer Res. 2018 Oct 29. pii: 1078-0432.CCR-18-1871.
Title:	A Novel Engineered Small Protein for Positron Emission Tomography Imaging of Human Programmed Death Ligand-1 : Validation in Mouse Models and Human Cancer Tissues.
Author:	Natarajan, Arutselvan\|Patel, Chirag B\|Ramakrishnan, Sindhuja\|Panesar, Paramjyot S\|Long, Steven R\|Gambhir, Sanjiv S
PMID:	30373750