Primary Site >> Biliary tract Cancer

Gene >> BRAF

Journal: Hepatology. 2002 Jun;35(6):1329-40.
Title: Stimulation of alpha2-adrenergic receptor inhibits cholangiocarcinoma growth through modulation of Raf-1 and B-Raf activities.
Author: Kanno, Noriatsu|Lesage, Gene|Phinizy, Jo Lynne|Glaser, Shannon|Francis, Heather|Alpini, Gianfranco
PMID: 12029618
Journal: Gut. 2003 May;52(5):706-12.
Title: Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma.
Author: Tannapfel, A|Sommerer, F|Benicke, M|Katalinic, A|Uhlmann, D|Witzigmann, H|Hauss, J|Wittekind, C
PMID: 12692057
Journal: Am J Physiol Gastrointest Liver Physiol. 2004 Jun;286(6):G973-82.
Title: Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways.
Author: Alpini, Gianfranco|Kanno, Noriatsu|Phinizy, Jo Lynne|Glaser, Shannon|Francis, Heather|Taffetani, Silvia|LeSage, Gene
PMID: 14701718
Journal: Mod Pathol. 2004 Nov;17(11):1386-91.
Title: The V599E BRAF mutation is uncommon in biliary tract cancers.
Author: Goldenberg, David|Rosenbaum, Eli|Argani, Pedram|Wistuba, Ignacio I|Sidransky, David|Thuluvath, Paul J|Hidalgo, Manuel|Califano, Joseph|Maitra, Anirban
PMID: 15181454
Journal: Virchows Arch. 2004 Aug;445(2):179-82. Epub 2004 Jun 19.
Title: Mutational analysis of BRAF in gallbladder carcinomas in association with K-ras and p53 mutations and microsatellite instability.
Author: Saetta, Angelica A|Papanastasiou, Pollyanthi|Michalopoulos, Nikolaos V|Gigelou, Fanie|Korkolopoulou, Penelope|Bei, Thaleia|Patsouris, Efstratios
PMID: 15221372
Journal: Tumour Biol. 2007;28(5):290-300. Epub 2007 Oct 26.
Title: Molecular testing for microsatellite instability and DNA mismatch repair defects in hereditary and sporadic colorectal cancers--ready for prime time?
Author: Soreide, Kjetil
PMID: 17962726
Journal: J Gastrointest Surg. 2009 Aug;13(8):1510-6.
Title: Molecular analysis of PIK3CA, BRAF, and RAS oncogenes in periampullary and ampullary adenomas and carcinomas.
Author: Schonleben, Frank|Qiu, Wanglong|Allendorf, John D|Chabot, John A|Remotti, Helen E|Su, Gloria H
PMID: 19440799
Journal: Br J Cancer. 2010 Jan 5;102(1):68-72.
Title: Sorafenib in patients with advanced biliary tract carcinoma: a phase II trial.
Author: Bengala, C|Bertolini, F|Malavasi, N|Boni, C|Aitini, E|Dealis, C|Zironi, S|Depenni, R|Fontana, A|Del Giovane, C|Luppi, G|Conte, P
PMID: 19935794
Journal: Biomed Pharmacother. 2011 Feb;65(1):22-6.
Title: KRAS and PIK3CA but not BRAF genes are frequently mutated in Chinese cholangiocarcinoma patients.
Author: Xu, Rui Feng|Sun, Ji Ping|Zhang, Shi Rong|Zhu, Guan Shan|Li, Li Bo|Liao, Yu Lin|Xie, Jian Ming|Liao, Wang Jun
PMID: 21051183
Journal: Appl Immunohistochem Mol Morphol. 2011 Mar;19(2):133-40.
Title: Mutations in the RAS/RAF/MAP kinase pathway commonly occur in gallbladder adenomas but are uncommon in gallbladder adenocarcinomas.
Author: Pai, Rish K|Mojtahed, Kaveh|Pai, Reetesh K
PMID: 21307665
Journal: Hum Pathol. 2012 Mar;43(3):440-5.
Title: Intraductal tubulopapillary neoplasm of the bile duct: potential origin from peribiliary cysts.
Author: Zen, Yoh|Amarapurkar, Anjali D|Portmann, Bernard C
PMID: 21813159
Journal: Gastroenterology. 2012 Apr;142(4):1021-1031.e15.
Title: Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors.
Author: Andersen, Jesper B|Spee, Bart|Blechacz, Boris R|Avital, Itzhak|Komuta, Mina|Barbour, Andrew|Conner, Elizabeth A|Gillen, Matthew C|Roskams, Tania|Roberts, Lewis R|Factor, Valentina M|Thorgeirsson, Snorri S
PMID: 22178589
Journal: Oncologist. 2012;17(1):72-9.
Title: Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping.
Author: Borger, Darrell R|Tanabe, Kenneth K|Fan, Kenneth C|Lopez, Hector U|Fantin, Valeria R|Straley, Kimberly S|Schenkein, David P|Hezel, Aram F|Ancukiewicz, Marek|Liebman, Hannah M|Kwak, Eunice L|Clark, Jeffrey W|Ryan, David P|Deshpande, Vikram|Dias-Santagata,
PMID: 22180306
Journal: Hum Pathol. 2013 Jul;44(7):1216-22.
Title: Molecular profiling of cholangiocarcinoma shows potential for targeted therapy treatment decisions.
Author: Voss, Jesse S|Holtegaard, Leonard M|Kerr, Sarah E|Fritcher, Emily G Barr|Roberts, Lewis R|Gores, Gregory J|Zhang, Jun|Highsmith, W Edward|Halling, Kevin C|Kipp, Benjamin R
PMID: 23391413
Journal: Ann Oncol. 2013 Dec;24(12):3061-5.
Title: A phase II trial of gemcitabine, irinotecan and panitumumab in advanced cholangiocarcinoma.
Author: Sohal, D P S|Mykulowycz, K|Uehara, T|Teitelbaum, U R|Damjanov, N|Giantonio, B J|Carberry, M|Wissel, P|Jacobs-Small, M|O'Dwyer, P J|Sepulveda, A|Sun, W
PMID: 24146220
Journal: Hum Pathol. 2013 Dec;44(12):2768-73.
Title: The frequency of KRAS and BRAF mutations in intrahepatic cholangiocarcinomas and their correlation with clinical outcome.
Author: Robertson, Scott|Hyder, Omar|Dodson, Rebecca|Nayar, Suresh K|Poling, Justin|Beierl, Katie|Eshleman, James R|Lin, Ming-Tseh|Pawlik, Timothy M|Anders, Robert A
PMID: 24139215
Journal: Gastroenterology. 2013 Apr;144(4):829-40.
Title: Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes.
Author: Sia, Daniela|Hoshida, Yujin|Villanueva, Augusto|Roayaie, Sasan|Ferrer, Joana|Tabak, Barbara|Peix, Judit|Sole, Manel|Tovar, Victoria|Alsinet, Clara|Cornella, Helena|Klotzle, Brandy|Fan, Jian-Bing|Cotsoglou, Christian|Thung, Swan N|Fuster, Josep|Waxman, Sam
PMID: 23295441
Journal: Hepatology. 2014 Apr;59(4):1427-34.
Title: Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma.
Author: Arai, Yasuhito|Totoki, Yasushi|Hosoda, Fumie|Shirota, Tomoki|Hama, Natsuko|Nakamura, Hiromi|Ojima, Hidenori|Furuta, Koh|Shimada, Kazuaki|Okusaka, Takuji|Kosuge, Tomoo|Shibata, Tatsuhiro
PMID: 24122810
Journal: Mod Pathol. 2014 May;27(5):731-9.
Title: High throughput molecular profiling reveals differential mutation patterns in intrahepatic cholangiocarcinomas arising in chronic advanced liver diseases.
Author: Jang, Sejin|Chun, Sung-Min|Hong, Seoung-Mo|Sung, Chang Ohk|Park, Hosub|Kang, Hyo Jeong|Kim, Kyu-pyo|Lee, Young Joo|Yu, Eunsil
PMID: 24186137
Journal: Mod Pathol. 2014 May;27(5):665-74.
Title: Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels.
Author: Mikhitarian, Kaidi|Pollen, Maressa|Zhao, Zhiguo|Shyr, Yu|Merchant, Nipun B|Parikh, Alexander|Revetta, Frank|Washington, M Kay|Vnencak-Jones, Cindy|Shi, Chanjuan
PMID: 24186143
Journal: Mod Pathol. 2014 Jul;27(7):1028-34.
Title: BRAF V600E-specific immunohistochemistry reveals low mutation rates in biliary tract cancer and restriction to intrahepatic cholangiocarcinoma.
Author: Goeppert, Benjamin|Frauenschuh, Lena|Renner, Marcus|Roessler, Stephanie|Stenzinger, Albrecht|Klauschen, Frederick|Warth, Arne|Vogel, Monika Nadja|Mehrabi, Arianeb|Hafezi, Mohammadreza|Boehmer, Katja|von Deimling, Andreas|Schirmacher, Peter|Weichert, Wilko
PMID: 24309328
Journal: J Gastroenterol Hepatol. 2014 May;29(5):1119-25.
Title: Clinicopathological and prognostic significances of EGFR, KRAS and BRAF mutations in biliary tract carcinomas in Taiwan.
Author: Chang, Yu-Ting|Chang, Ming-Chu|Huang, Kai-Wen|Tung, Chien-Chih|Hsu, Chiun|Wong, Jau-Min
PMID: 24372748
Journal: Ann Surg Oncol. 2014 Nov;21(12):3827-34.
Title: Genomic profiling of intrahepatic cholangiocarcinoma: refining prognosis and identifying therapeutic targets.
Author: Zhu, Andrew X|Borger, Darrell R|Kim, Yuhree|Cosgrove, David|Ejaz, Aslam|Alexandrescu, Sorin|Groeschl, Ryan Thomas|Deshpande, Vikram|Lindberg, James M|Ferrone, Cristina|Sempoux, Christine|Yau, Thomas|Poon, Ronnie|Popescu, Irinel|Bauer, Todd W|Gamblin, T Cl
PMID: 24889489
Journal: Ecancermedicalscience. 2014 Nov 6;8:479.
Title: Dramatic response to dabrafenib and trametinib combination in a BRAF V600E-mutated cholangiocarcinoma: implementation of a molecular tumour board and next-generation sequencing for personalized medicine.
Author: Loaiza-Bonilla, Arturo|Clayton, Erica|Furth, Emma|O'Hara, Mark|Morrissette, Jennifer
PMID: 25435907
Journal: PLoS One. 2014 Dec 23;9(12):e115383.
Title: Mutation profiling in cholangiocarcinoma: prognostic and therapeutic implications.
Author: Churi, Chaitanya R|Shroff, Rachna|Wang, Ying|Rashid, Asif|Kang, HyunSeon C|Weatherly, Jacqueline|Zuo, Mingxin|Zinner, Ralph|Hong, David|Meric-Bernstam, Funda|Janku, Filip|Crane, Christopher H|Mishra, Lopa|Vauthey, Jean-Nicholas|Wolff, Robert A|Mills, Gord
PMID: 25536104
Journal: Histopathology. 2015 Oct;67(4):562-7.
Title: BRAF V600E mutational status in bile duct adenomas and hamartomas.
Author: Pujals, Anais|Bioulac-Sage, Paulette|Castain, Claire|Charpy, Cecile|Zafrani, Elie Serge|Calderaro, Julien
PMID: 25704541
Journal: Exp Mol Pathol. 2015 Oct;99(2):240-4.
Title: Molecular profiling of intrahepatic and extrahepatic cholangiocarcinoma using next generation sequencing.
Author: Putra, Juan|de Abreu, Francine B|Peterson, Jason D|Pipas, J Marc|Mody, Kabir|Amos, Christopher I|Tsongalis, Gregory J|Suriawinata, Arief A
PMID: 26189129
Journal: Mod Pathol. 2015 Sep;28(9):1249-64.
Title: Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases.
Author: Schlitter, Anna Melissa|Jang, Kee-Taek|Kloppel, Gunter|Saka, Burcu|Hong, Seung-Mo|Choi, Hyejeong|Offerhaus, George Johan|Hruban, Ralph H|Zen, Yoh|Konukiewitz, Bjorn|Regel, Ivonne|Allgauer, Michael|Balci, Serdar|Basturk, Olca|Reid, Michelle D|Esposito, Ire
PMID: 26111977
Journal: Nat Commun. 2015 Jan 22;6:6087.
Title: Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma.
Author: Sia, Daniela|Losic, Bojan|Moeini, Agrin|Cabellos, Laia|Hao, Ke|Revill, Kate|Bonal, Dennis|Miltiadous, Oriana|Zhang, Zhongyang|Hoshida, Yujin|Cornella, Helena|Castillo-Martin, Mireia|Pinyol, Roser|Kasai, Yumi|Roayaie, Sasan|Thung, Swan N|Fuster, Josep|Schw
PMID: 25608663
Journal: Best Pract Res Clin Gastroenterol. 2015 Apr;29(2):233-44.
Title: Pathogenesis of cholangiocarcinoma: From genetics to signalling pathways.
Author: Kongpetch, Sarinya|Jusakul, Apinya|Ong, Choon Kiat|Lim, Weng Khong|Rozen, Steven G|Tan, Patrick|Teh, Bin Tean
PMID: 25966424
Journal: Clin Cancer Res. 2016 Jan 15;22(2):291-300.
Title: Molecular Pathogenesis and Targeted Therapies for Intrahepatic Cholangiocarcinoma.
Author: Moeini, Agrin|Sia, Daniela|Bardeesy, Nabeel|Mazzaferro, Vincenzo|Llovet, Josep M
PMID: 26405193
Journal: Hepatol Res. 2016 Jun;46(7):713-8.
Title: Intraductal tubulopapillary neoplasm of the bile duct: A case report and review of the published work.
Author: Nakagawa, Takashi|Arisaka, Yoshifumi|Ajiki, Tetsuo|Fujikura, Kohei|Masuda, Atsuhiro|Takenaka, Mamoru|Shiomi, Hideyuki|Okabe, Yoshihiro|Fukumoto, Takumi|Ku, Yonson|Azuma, Takeshi|Zen, Yoh
PMID: 26459784
Journal: J Clin Pathol. 2016 May;69(5):403-8.
Title: Comprehensive genomic profiling of extrahepatic cholangiocarcinoma reveals a long tail of therapeutic targets.
Author: Lee, Hwajeong|Wang, Kai|Johnson, Adrienne|Jones, David M|Ali, Siraj M|Elvin, Julia A|Yelensky, Roman|Lipson, Doron|Miller, Vincent A|Stephens, Philip J|Javle, Milind|Ross, Jeffrey S
PMID: 26500333
Journal: Mod Pathol. 2016 Mar;29(3):293-301.
Title: Cholangiocarcinoma with intraductal tubular growth pattern versus intraductal papillary growth pattern.
Author: Tsukahara, Tetsuo|Shimoyama, Yoshie|Ebata, Tomoki|Yokoyama, Yukihiro|Igami, Tsuyoshi|Sugawara, Gen|Mizuno, Takashi|Yamaguchi, Junpei|Nakamura, Shigeo|Nagino, Masato
PMID: 26769137
Journal: Cancer Metastasis Rev. 2016 Jun;35(2):263-75.
Title: Genomics of gallbladder cancer: the case for biomarker-driven clinical trial design.
Author: Sicklick, Jason K|Fanta, Paul T|Shimabukuro, Kelly|Kurzrock, Razelle
PMID: 26857926
Journal: Oncotarget. 2016 Jul 19;7(29):46750-46767.
Title: The landscape of targeted therapies for cholangiocarcinoma: current status and emerging targets.
Author: Chong, Dawn Q|Zhu, Andrew X
PMID: 27102149
Journal: J Gastrointest Oncol. 2016 Oct;7(5):797-803.
Title: Molecular profiling of biliary tract cancer: a target rich disease.
Author: Jain, Apurva|Javle, Milind
PMID: 27747093
Journal: Crit Rev Oncol Hematol. 2016 Nov;107:111-118.
Title: Molecular characteristics of biliary tract cancer.
Author: Sohal, Davendra P S|Shrotriya, Shiva|Abazeed, Mohamed|Cruise, Michael|Khorana, Alok
PMID: 27823638
Journal: Jpn Clin Med. 2016 Dec 13;7:33-39.
Title: KRAS Mutation as a Potential Prognostic Biomarker of Biliary Tract Cancers.
Author: Yokoyama, Masaaki|Ohnishi, Hiroaki|Ohtsuka, Kouki|Matsushima, Satsuki|Ohkura, Yasuo|Furuse, Junji|Watanabe, Takashi|Mori, Toshiyuki|Sugiyama, Masanori
PMID: 28008299
Journal: J Gastrointest Oncol. 2016 Dec;7(6):E98-E102.
Title: Impressive response to dual BRAF and MEK inhibition in patients with BRAF mutant intrahepatic cholangiocarcinoma-2 case reports and a brief review.
Author: Lavingia, Viraj|Fakih, Marwan
PMID: 28078132
Journal: Histopathology. 2017 Feb;70(3):485-491.
Title: BRAF V600E mutation in biliary proliferations associated with alpha1 -antitrypsin deficiency.
Author: Angkathunyakul, Napat|Rosini, Francesca|Heaton, Nigel|Foskett, Pierre|Quaglia, Alberto
PMID: 27627051
Journal: Cancer Control. 2017 Jul-Sep;24(3):1073274817729241.
Title: Systemic and Adjuvant Therapies for Intrahepatic Cholangiocarcinoma.
Author: Chun, Yun Shin|Javle, Milind
PMID: 28975832
Journal: Pathol Res Pract. 2017 Aug;213(8):1010-1013.
Title: Adenosquamous gallbladder carcinoma: Multigene hotspot mutational profiling reveals a monoclonal origin of the two components.
Author: Galuppini, Francesca|Salmaso, Roberta|Valentini, Elisa|Lanza, Cristiano|Maretto, Isacco|Nitti, Donato|Rugge, Massimo|Fassan, Matteo
PMID: 28698100
Journal: J Gastrointest Oncol. 2017 Apr;8(2):E32-E38.
Title: Combined dabrafenib and trametinib treatment in a case of chemotherapy-refractory extrahepatic BRAF V600E mutant cholangiocarcinoma: dramatic clinical and radiological response with a confusing synchronic new liver lesion.
Author: Kocsis, Judit|Arokszallasi, Anita|Andras, Csilla|Balogh, Ingrid|Beres, Edit|Deri, Julia|Petak, Istvan|Janvary, Levente|Horvath, Zsolt
PMID: 28480077
Journal: Onco Targets Ther. 2017 Feb 17;10:965-971.
Title: BRAF(V600) mutations in solid tumors, other than metastatic melanoma and papillary thyroid cancer, or multiple myeloma: a screening study.
Author: Cohn, Allen L|Day, Bann-Mo|Abhyankar, Sarang|McKenna, Edward|Riehl, Todd|Puzanov, Igor
PMID: 28255242
Journal: J Formos Med Assoc. 2017 Jun;116(6):464-468.
Title: Mutation analysis and copy number changes of KRAS and BRAF genes in Taiwanese cases of biliary tract cholangiocarcinoma.
Author: Huang, Wen-Chih|Tsai, Chien-Chen|Chan, Chih-Chieh
PMID: 27745798
Journal: Br J Cancer. 2018 Feb 20;118(4):462-470.
Title: Phase I dose-escalation study of copanlisib in combination with gemcitabine or cisplatin plus gemcitabine in patients with advanced cancer.
Author: Kim, R D|Alberts, S R|Pena, C|Genvresse, I|Ajavon-Hartmann, A|Xia, C|Kelly, A|Grilley-Olson, J E
PMID: 29348486
Journal: Future Oncol. 2018 Mar;14(6):553-566.
Title: Novel targeted therapy strategies for biliary tract cancers and hepatocellular carcinoma.
Author: DeLeon, Thomas T|Ahn, Daniel H|Bogenberger, James M|Anastasiadis, Panos Z|Arora, Mansi|Ramanathan, Ramesh K|Aqel, Bashar A|Vasmatzis, George|Truty, Mark J|Oklu, Rahmi|Bekaii-Saab, Tanios S|Borad, Mitesh J
PMID: 29460642
Journal: Oncologist. 2018 Sep;23(9):998-1003.
Title: Hybrid Capture-Based Tumor Sequencing and Copy Number Analysis to Confirm Origin of Metachronous Metastases in BRCA1-Mutant Cholangiocarcinoma Harboring a Novel YWHAZ-BRAF Fusion.
Author: Lim, Huat C|Montesion, Meagan|Botton, Thomas|Collisson, Eric A|Umetsu, Sarah E|Behr, Spencer C|Gordan, John D|Stephens, Phil J|Kelley, Robin K
PMID: 29622700
Journal: Z Gastroenterol. 2018 Apr;56(4):384-397.
Title: [ASCO- and ESMO-update 2017 - highlights of the 53. meeting of the American Society of Clinical Oncology/ASCO 2017 and European Society for Medical Oncology/ESMO congress 2017].
Author: Ettrich, Thomas J|Ebert, Matthias|Lorenzen, Sylvie|Moehler, Markus|Vogel, Arndt|Witkowski, Lukas|Seufferlein, Thomas|Reinacher-Schick, Anke
PMID: 29642252
Journal: Hum Pathol. 2018 Aug;78:131-137.
Title: Mucinous intrahepatic cholangiocarcinoma: a distinct variant.
Author: Chi, Zhikai|Bhalla, Amarpreet|Saeed, Omer|Cheng, Liang|Curless, Kendra|Wang, Hanlin L|Patil, Deepa T|Lin, Jingmei
PMID: 29698701
Journal: Invest New Drugs. 2018 May 22. pii: 10.1007/s10637-018-0600-2.
Title: Phase 1b investigation of the MEK inhibitor binimetinib in patients with advanced or metastatic biliary tract cancer.
Author: Finn, R S|Ahn, D H|Javle, M M|Tan, B R Jr|Weekes, C D|Bendell, J C|Patnaik, A|Khan, G N|Laheru, D|Chavira, R|Christy-Bittel, J|Barrett, E|Sawyer, M B|Bekaii-Saab, Tanios S
PMID: 29785570
Journal: Jpn J Clin Oncol. 2018 Aug 1;48(8):703-711.
Title: New developments in systemic therapy for advanced biliary tract cancer.
Author: Morizane, Chigusa|Ueno, Makoto|Ikeda, Masafumi|Okusaka, Takuji|Ishii, Hiroshi|Furuse, Junji
PMID: 29893894