Primary Site >> Liver Cancer

Gene >> AIFM1

Journal: J Biol Chem. 2003 Jun 13;278(24):22071-8.
Title: Hepatitis B virus X protein induces cell death by causing loss of mitochondrial membrane potential.
Author: Shirakata, Yumiko|Koike, Katsuro
PMID: 12676947
Journal: Zhonghua Gan Zang Bing Za Zhi. 2006 Apr;14(4):285-8.
Title: [Effect of hydroxycamptothecin on apoptosis-inducing factor (AIF) expression and on AIF translocation in human hepatocellular cancer cell SMMC-7721].
Author: Fu, Yu-rong|Qiu, Zong-yin|Yan, Yu-rong
PMID: 16635299
Journal: Mitochondrion. 2006 Aug;6(4):211-7.
Title: Hydroxycamptothecin-induced apoptosis in hepatoma SMMC-7721 cells and the role of mitochondrial pathway.
Author: Fu, Yu-Rong|Yi, Zheng-Jun|Yan, Yu-Rong|Qiu, Zong-Yin
PMID: 16926123
Journal: Naunyn Schmiedebergs Arch Pharmacol. 2006 Dec;374(3):223-33.
Title: Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery.
Author: Lu, Pin-Hsuan|Kung, Fan-Lu|Kuo, Sheng-Chu|Chueh, Shih-Chieh|Guh, Jih-Hwa
PMID: 17102938
Journal: APMIS. 2006 Dec;114(12):867-73.
Title: Immunohistochemical and mutational analysis of apoptosis-inducing factor (AIF) in colorectal carcinomas.
Author: Jeong, Eun Goo|Lee, Jong Woo|Soung, Young Hwa|Nam, Suk Woo|Kim, Sang Ho|Lee, Jung Young|Yoo, Nam Jin|Lee, Sug Hyung
PMID: 17207087
Journal: Biochem Pharmacol. 2007 Jun 30;74(1):10-9.
Title: Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways.
Author: Chen, Ying-Cheng|Lu, Pin-Hsuan|Pan, Shiow-Lin|Teng, Che-Ming|Kuo, Sheng-Chu|Lin, Tsung-Ping|Ho, Yunn-Fang|Huang, Yu-Chun|Guh, Jih-Hwa
PMID: 17475221
Journal: J Proteome Res. 2008 Feb;7(2):611-20.
Title: Identification of hepatocellular-carcinoma-associated antigens and autoantibodies by serological proteome analysis combined with protein microarray.
Author: Li, Lan|Chen, Su-hong|Yu, Chao-hui|Li, You-ming|Wang, Sheng-qi
PMID: 18161940
Journal: Mol Cancer Ther. 2008 Feb;7(2):350-60.
Title: CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo.
Author: Wang, Shih-Wei|Pan, Shiow-Lin|Huang, Yu-Chun|Guh, Jih-Hwa|Chiang, Po-Cheng|Huang, Der-Yi|Kuo, Sheng-Chu|Lee, Kuo-Hsiung|Teng, Che-Ming
PMID: 18281518
Journal: J Bioenerg Biomembr. 2008 Dec;40(6):607-18.
Title: Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells : ROS-mediated cell death by 3-BrPA.
Author: Kim, Ji Su|Ahn, Keun Jae|Kim, Jeong-Ah|Kim, Hye Mi|Lee, Jong Doo|Lee, Jae Myun|Kim, Se Jong|Park, Jeon Han
PMID: 19067133
Journal: Cell Immunol. 2009;255(1-2):76-81.
Title: Intracellularly expressed granulysin induced apoptosis in hepatoma cells and role of mitochondrial apoptotic pathway.
Author: Yi, Zhengjun|Fu, Yurong|Jin, Guangxiang|Li, Meng|Zhang, Xia|Song, Wei
PMID: 19111751
Journal: J Pharmacol Exp Ther. 2009 May;329(2):808-19.
Title: Dehydrocostuslactone, a medicinal plant-derived sesquiterpene lactone, induces apoptosis coupled to endoplasmic reticulum stress in liver cancer cells.
Author: Hsu, Ya-Ling|Wu, Ling-Yu|Kuo, Po-Lin
PMID: 19188481
Journal: Cancer Biol Ther. 2009 May;8(9):792-8. Epub 2009 May 8.
Title: Heat shock protein 70 silencing enhances apoptosis inducing factor-mediated cell death in hepatocellular carcinoma HepG2 cells.
Author: Zhu, Qing|Xu, Yan-Ming|Wang, Li-Feng|Zhang, Yong|Wang, Fang|Zhao, Jing|Jia, Lin-Tao|Zhang, Wang-Gang|Yang, An-Gang
PMID: 19270509
Journal: Int J Oncol. 2009 Oct;35(4):717-24.
Title: Mitochondrial-dependent caspase activation pathway is involved in baicalein-induced apoptosis in human hepatoma J5 cells.
Author: Kuo, Hsiu-Maan|Tsai, Hung-Chieh|Lin, Ya-Ling|Yang, Jai-Sing|Huang, An-Cheng|Yang, Mei-Due|Hsu, Shu-Chun|Chung, Meng-Chin|Gibson Wood, W|Chung, Jing-Gung
PMID: 19724907
Journal: Chem Biol Interact. 2010 Jan 5;183(1):142-53.
Title: 2'-epi-2'-O-Acetylthevetin B extracted from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.
Author: Feng, Bo|Guo, Yue-Wei|Huang, Cai-Guo|Li, Liang|Chen, Ruo-Hua|Jiao, Bing-Hua
PMID: 19874809
Journal: Cancer Lett. 2010 Dec 1;298(1):128-38.
Title: Ursolic acid induces doxorubicin-resistant HepG2 cell death via the release of apoptosis-inducing factor.
Author: Yang, Lu|Liu, Xiaozhuo|Lu, Zengbing|Yuet-Wa Chan, Judy|Zhou, Linli|Fung, Kwok-Pui|Wu, Ping|Wu, Shihua
PMID: 20630652
Journal: Cancer Lett. 2010 Oct 1;296(1):96-105.
Title: Reactive oxygen species-mitochondria pathway involved in LYG-202-induced apoptosis in human hepatocellular carcinoma HepG(2) cells.
Author: Chen, Fei-Hong|Zhang, Lin-Bo|Qiang, Lei|Yang, Zhen|Wu, Tian|Zou, Mei-Juan|Tao, Lei|You, Qi-Dong|Li, Zhi-Yu|Yang, Yong|Guo, Qing-Long
PMID: 20580989
Journal: Int J Cancer. 2010 May 1;126(9):2049-66.
Title: Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway.
Author: Seitz, Sarah J|Schleithoff, Elisa Schulze|Koch, Andreas|Schuster, Andre|Teufel, Andreas|Staib, Frank|Stremmel, Wolfgang|Melino, Gerry|Krammer, Peter H|Schilling, Tobias|Muller, Martina
PMID: 19711344
Journal: J Cell Biochem. 2011 Apr;112(4):1176-91.
Title: Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells.
Author: Lin, Meng-Liang|Lu, Yao-Cheng|Su, Hong-Lin|Lin, Hsin-Ting|Lee, Chuan-Chun|Kang, Shang-En|Lai, Tan-Chen|Chung, Jing-Gung|Chen, Shih-Shun
PMID: 21308745
Journal: J Agric Food Chem. 2011 May 11;59(9):5109-16.
Title: Blazeispirol A from Agaricus blazei fermentation product induces cell death in human hepatoma Hep 3B cells through caspase-dependent and caspase-independent pathways.
Author: Su, Zheng-Yuan|Tung, Yen-Chen|Hwang, Lucy Sun|Sheen, Lee-Yan
PMID: 21417302
Journal: Biochem Biophys Res Commun. 2011 Nov 11;415(1):68-74.
Title: Hepatitis B virus X protein reduces starvation-induced cell death through activation of autophagy and inhibition of mitochondrial apoptotic pathway.
Author: Mao, Yi|Da, Liang|Tang, Hong|Yang, Jiali|Lei, Yinrui|Tiollais, Pierre|Li, Tsaiping|Zhao, Mujun
PMID: 22020078
Journal: Exp Toxicol Pathol. 2012 Jul;64(5):403-10.
Title: beta-D-Glucosyl-(1-4)-alpha-L-thevetosides of 17beta-digitoxigenin from seeds of Cerbera manghas L. induces apoptosis in human hepatocellular carcinoma HepG2 cells.
Author: Feng, Bo|Guo, Yue-Wei|Huang, Cai-Guo|Li, Liang|Jiao, Bing-Hua
PMID: 21036567
Journal: J Biosci Bioeng. 2012 Jul;114(1):104-9.
Title: Residual powders from Shochu distillation remnants induce apoptosis in human hepatoma cells via the caspase-independent pathway.
Author: Ohgidani, Masahiro|Komizu, Yuji|Goto, Koichi|Ueoka, Ryuichi
PMID: 22560085
Journal: Planta Med. 2012 Jun;78(9):881-9.
Title: In vitro cytotoxicity of cyclodextrin-bonded birch bark extract.
Author: Hertrampf, Anke|Grundemann, Carsten|Jager, Sebastian|Laszczyk, Melanie|Giesemann, Torsten|Huber, Roman
PMID: 22573365
Journal: Biochem Biophys Res Commun. 2012 Jun 22;423(1):26-31.
Title: Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation.
Author: Zhang, Yuan-Yuan|Zhou, Li-Ming
PMID: 22609775
Journal: Eur J Pharmacol. 2012 Sep 15;691(1-3):61-8.
Title: NG, a novel PABA/NO-based oleanolic acid derivative, induces human hepatoma cell apoptosis via a ROS/MAPK-dependent mitochondrial pathway.
Author: Liu, Ling|Fu, Junjie|Li, Tingting|Cui, Ran|Ling, Jingjing|Yu, Xing|Ji, Hui|Zhang, Yihua
PMID: 22824464
Journal: J Proteome Res. 2012 Oct 5;11(10):4803-13.
Title: Hepatitis B virus encoded X protein suppresses apoptosis by inhibition of the caspase-independent pathway.
Author: Liu, Haiying|Yuan, Yanzhi|Guo, Hongyan|Mitchelson, Keith|Zhang, Ke|Xie, Lan|Qin, Wenyan|Lu, Ying|Wang, Jian|Guo, Yong|Zhou, Yuxiang|He, Fuchu
PMID: 22871131
Journal: Biochem Biophys Res Commun. 2013 Apr 19;433(4):432-7.
Title: Generation of reactive oxygen species by a novel berberine-bile acid analog mediates apoptosis in hepatocarcinoma SMMC-7721 cells.
Author: Li, Qingyong|Zhang, Li|Zu, Yuangang|Liu, Tianyu|Zhang, Baoyou|He, Wuna
PMID: 23518073
Journal: Int J Biochem Cell Biol. 2013 Nov;45(11):2632-42.
Title: ONTD induces apoptosis of human hepatoma Bel-7402 cells via a MAPK-dependent mitochondrial pathway and the depletion of intracellular glutathione.
Author: Tan, Jiani|Lai, Zhonghui|Liu, Ling|Long, Wenyan|Chen, Tong|Zha, Jun|Wang, Linna|Chen, Meiyu|Ji, Hui|Lai, Yisheng
PMID: 24036456
Journal: Molecules. 2013 Aug 22;18(9):10146-61.
Title: Sinulariolide induced hepatocellular carcinoma apoptosis through activation of mitochondrial-related apoptotic and PERK/eIF2alpha/ATF4/CHOP pathway.
Author: Chen, Yi-Jen|Su, Jui-Hsin|Tsao, Chia-Yu|Hung, Chun-Tzu|Chao, Hsiang-Hao|Lin, Jen-Jie|Liao, Ming-Hui|Yang, Zih-Yan|Huang, Han Hisang|Tsai, Feng-Jen|Weng, Shun-Hsiang|Wu, Yu-Jen
PMID: 23973991
Journal: Oncol Rep. 2013 Sep;30(3):1323-8.
Title: Sirt3 is a tumor suppressor in lung adenocarcinoma cells.
Author: Xiao, Kui|Jiang, Jiehan|Wang, Wei|Cao, Shan|Zhu, Liming|Zeng, Huihui|Ouyang, Ruoyun|Zhou, Rui|Chen, Ping
PMID: 23842789
Journal: Anticancer Agents Med Chem. 2013 Sep;13(7):1088-95.
Title: Suppression of oncoprotein Her-2 and DNA damage after treatment with Flavan-3- ol vitis labrusca extract.
Author: Scola, Gustavo|Fernandes Correia Laurino, Claudia Cilene|Menin, Eveline|Salvador, Mirian
PMID: 23343084
Journal: PLoS One. 2013 Jul 17;8(7):e68981.
Title: Silencing of Pokemon enhances caspase-dependent apoptosis via fas- and mitochondria-mediated pathways in hepatocellular carcinoma cells.
Author: Zhang, Yu-Qin|Xiao, Chuan-Xing|Lin, Bi-Yun|Shi, Ying|Liu, Yun-Peng|Liu, Jing-Jing|Guleng, Bayasi|Ren, Jian-Lin
PMID: 23874836
Journal: Food Chem Toxicol. 2014 Jan;63:38-47.
Title: The activation of p38 and JNK by ROS, contribute to OLO-2-mediated intrinsic apoptosis in human hepatocellular carcinoma cells.
Author: Zhang, Zhenzhen|Zhang, Chao|Ding, Ye|Zhao, Qian|Yang, Lifang|Ling, Jingjing|Liu, Ling|Ji, Hui|Zhang, Yihua
PMID: 24211866
Journal: Mol Cancer. 2014 Mar 16;13:59.
Title: Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor.
Author: Zhou, Huan|Xu, Minying|Gao, Ya|Deng, Zhigang|Cao, Hanwei|Zhang, Wenqing|Wang, Qiao|Zhang, Bing|Song, Gang|Zhan, Yanyan|Hu, Tianhui
PMID: 24628719
Journal: Biol Pharm Bull. 2014;37(4):608-17.
Title: Cordycepol C induces caspase-independent apoptosis in human hepatocellular carcinoma HepG2 cells.
Author: Sun, Yi-Sheng|Lv, Long-Xian|Zhao, Zhao|He, Xian|You, Lu|Liu, Ji-Kai|Li, Yong-Quan
PMID: 24694607
Journal: J Drug Target. 2014 Jul;22(6):543-52.
Title: Transport and killing mechanism of a novel camptothecin-deoxycholic acid derivate on hepatocellular carcinoma cells.
Author: Li, Qingyong|Liu, Tianyu|Li, Yunchao|Luo, Shuyue|Zhu, Qiaochu|Zhang, Li|Zhao, Tengfei
PMID: 24725118
Journal: Biochem Biophys Res Commun. 2014 May 23;448(1):8-14.
Title: Adenosine induces apoptosis in human liver cancer cells through ROS production and mitochondrial dysfunction.
Author: Ma, Yunfang|Zhang, Jun|Zhang, Qi|Chen, Ping|Song, Junyao|Yu, Shunji|Liu, Hui|Liu, Fuchen|Song, Chunhua|Yang, Dongqin|Liu, Jie
PMID: 24727456
Journal: J Nanosci Nanotechnol. 2014 May;14(5):3817-21.
Title: Inhibition of water activated by far infrared functional ceramics on proliferation of hepatoma cells.
Author: Zhang, Dongmei|Liang, Jinsheng|Ding, Yan|Meng, Junping|Zhang, Guangchuan
PMID: 24734643
Journal: Cell Death Dis. 2014 May 15;5:e1230.
Title: beta-Lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells.
Author: Park, E J|Min, K-J|Lee, T-J|Yoo, Y H|Kim, Y-S|Kwon, T K
PMID: 24832602
Journal: Mol Med Rep. 2014 Oct;10(4):2093-8.
Title: Celecoxib induces apoptosis via a mitochondriadependent pathway in the H22 mouse hepatoma cell line.
Author: Shao, Dan|Kan, Mujie|Qiao, Ping|Pan, Yue|Wang, Zheng|Xiao, Xuanang|Li, Jing|Chen, Li
PMID: 25109418
Journal: NMR Biomed. 2014 Nov;27(11):1403-12.
Title: Dynamic contrast-enhanced MRI in mouse tumors at 11.7 T: comparison of three contrast agents with different molecular weights to assess the early effects of combretastatin A4.
Author: Fruytier, A-C|Magat, J|Neveu, M-A|Karroum, O|Bouzin, C|Feron, O|Jordan, B|Cron, G O|Gallez, B
PMID: 25323069
Journal: Med Oncol. 2015 Apr;32(4):101.
Title: Hesperetin induces the apoptosis of hepatocellular carcinoma cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species, ATP and calcium.
Author: Zhang, Jixiang|Song, Jia|Wu, Dandan|Wang, Jing|Dong, Weiguo
PMID: 25737432
Journal: Cell Physiol Biochem. 2015;37(1):361-74.
Title: 8-Methoxypsoralen Induces Intrinsic Apoptosis in HepG2 Cells: Involvement of Reactive Oxygen Species Generation and ERK1/2 Pathway Inhibition.
Author: Yang, Huan|Xiong, Jing|Luo, Wenjing|Yang, Jian|Xi, Tao
PMID: 26316083
Journal: PLoS One. 2015 Aug 7;10(8):e0134760.
Title: Embelin-Induced Apoptosis of Human Prostate Cancer Cells Is Mediated through Modulation of Akt and beta-Catenin Signaling.
Author: Park, Nahee|Baek, Hyoung Seok|Chun, Young-Jin
PMID: 26252009
Journal: Oncol Rep. 2016 Feb;35(2):669-75.
Title: Anticancer effect of xanthohumol induces growth inhibition and apoptosis of human liver cancer through NF-kappaB/p53-apoptosis signaling pathway.
Author: Zhao, Xiangqian|Jiang, Kai|Liang, Bin|Huang, Xiaoqiang
PMID: 26718026
Journal: Biochem Biophys Res Commun. 2016 Mar 25;472(1):137-43.
Title: Caspase-independent cell death mediated by apoptosis-inducing factor (AIF) nuclear translocation is involved in ionizing radiation induced HepG2 cell death.
Author: Sun, Hengwen|Yang, Shana|Li, Jianhua|Zhang, Yajie|Gao, Dongsheng|Zhao, Shenting
PMID: 26920061
Journal: Biomed Rep. 2016 Jul;5(1):73-78.
Title: Mechanism of apoptosis induction in human hepatocellular carcinoma cells following treatment with a gecko peptides mixture.
Author: Jin, Ying|Duan, Leng-Xin|Xu, Xin-Li|Ge, Wen-Jing|Li, Rui-Fang|Qiu, Xiang-Jun|Song, Ying|Cao, Shan-Shan|Wang, Jian-Gang
PMID: 27330750
Journal: Sci Rep. 2017 Apr 7;7:46134.
Title: Lanatoside C, a cardiac glycoside, acts through protein kinase Cdelta to cause apoptosis of human hepatocellular carcinoma cells.
Author: Chao, Min-Wu|Chen, Tzu-Hsuan|Huang, Han-Li|Chang, Yu-Wei|HuangFu, Wei-Chun|Lee, Yu-Ching|Teng, Che-Ming|Pan, Shiow-Lin
PMID: 28387249
Journal: Apoptosis. 2017 Nov;22(11):1362-1379.
Title: Modulation of adenylate cyclase signaling in association with MKK3/6 stabilization under combination of SAC and berberine to reduce HepG2 cell survivability.
Author: Sengupta, Dipanwita|Chowdhury, Kaustav Dutta|Chatterjee, Sujan|Sarkar, Avik|Paul, Soumosish|Sur, Pradip Kumar|Sadhukhan, Gobinda Chandra
PMID: 28836036
Journal: Oncol Rep. 2018 Jan;39(1):61-70.
Title: Crosstalk between p38 MAPK and caspase-9 regulates mitochondria-mediated apoptosis induced by tetra-alpha-(4-carboxyphenoxy) phthalocyanine zinc photodynamic therapy in LoVo cells.
Author: Wang, Yu|Xia, Chunhui|Lun, Zhiqiang|Lv, Yanxin|Chen, Wei|Li, Tao
PMID: 29115534
Journal: Cytotechnology. 2018 Apr;70(2):831-842.
Title: Melilotus indicus extract induces apoptosis in hepatocellular carcinoma cells via a mechanism involving mitochondria-mediated pathways.
Author: Abd El-Hafeez, Amer Ali|Khalifa, Hazim O|Elgawish, Rania Abdelrahman|Shouman, Samia A|Abd El-Twab, Magdy Hussein|Kawamoto, Seiji
PMID: 29372465
Journal: Biochem Biophys Res Commun. 2018 Apr 6;498(3):453-457.
Title: Overexpression of apoptosis-inducing factor mitochondrion-associated 1 (AIFM1) induces apoptosis by promoting the transcription of caspase3 and DRAM in hepatoma cells.
Author: Liu, Dongjie|Liu, Mingyang|Wang, Wenjing|Pang, Lijun|Wang, Zhenchang|Yuan, Chunwang|Liu, Kai
PMID: 29501488
Journal: Int J Oncol. 2018 Nov;53(5):2300-2308.
Title: Induction of apoptosis and G1 phase cell cycle arrest by Aster incisus in AGS gastric adenocarcinoma cells.
Author: Ngabire, Daniel|Seong, Yeong-Ae|Patil, Maheshkumar Prakash|Niyonizigiye, Irvine|Seo, Yong Bae|Kim, Gun-Do
PMID: 30226597
Journal: Environ Sci Pollut Res Int. 2018 Oct 6. pii: 10.1007/s11356-018-3339-6.
Title: Chitosan nanoparticles from Artemia salina inhibit progression of hepatocellular carcinoma in vitro and in vivo.
Author: Elkeiy, Mai M|Khamis, Abeer A|El-Gamal, Mona M|Abo Gazia, Maha M|Zalat, Zeinb A|El-Magd, Mohammed A
PMID: 30293105