Literatures

Primary Site >> Colorectal Cancer

Gene >> AES

1.
Journal:	J Clin Oncol. 1995 Apr;13(4):921-8.
Title:	Phase III randomized study of two fluorouracil combinations with either interferon alfa-2a or leucovorin for advanced colorectal cancer. Corfu-A Study Group.
Author:
PMID:	7707120

2.
Journal:	J Clin Oncol. 1996 Oct;14(10):2674-81.
Title:	Phase III randomized study to compare interferon alfa-2a in combination with fluorouracil versus fluorouracil alone in patients with advanced colorectal cancer.
Author:	Greco, F A\|Figlin, R\|York, M\|Einhorn, L\|Schilsky, R\|Marshall, E M\|Buys, S S\|Froimtchuk, M J\|Schuller, J\|Schuchter, L\|Buyse, M\|Ritter, L\|Man, A\|Yap, A K
PMID:	8874326

3.
Journal:	J Nucl Med. 1998 Nov;39(11):1937-43.
Title:	Delivery of therapeutic doses of radioiodine using bispecific antibody-targeted bivalent haptens.
Author:	Gautherot, E\|Le Doussal, J M\|Bouhou, J\|Manetti, C\|Martin, M\|Rouvier, E\|Barbet, J
PMID:	9829586

4.
Journal:	J Clin Oncol. 2002 Nov 1;20(21):4292-302.
Title:	Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types.
Author:	Baselga, J\|Rischin, D\|Ranson, M\|Calvert, H\|Raymond, E\|Kieback, D G\|Kaye, S B\|Gianni, L\|Harris, A\|Bjork, T\|Averbuch, S D\|Feyereislova, A\|Swaisland, H\|Rojo, F\|Albanell, J
PMID:	12409327

5.
Journal:	Clin Colorectal Cancer. 2006 Nov;6(4):278-87.
Title:	Xeloda in Adjuvant Colon Cancer Therapy (X-ACT) trial: overview of efficacy, safety, and cost-effectiveness.
Author:	Twelves, Chris J
PMID:	17241512

6.
Journal:	J Clin Oncol. 2007 Jan 1;25(1):102-9.
Title:	Phase III trial of capecitabine plus oxaliplatin as adjuvant therapy for stage III colon cancer: a planned safety analysis in 1,864 patients.
Author:	Schmoll, Hans-Joachim\|Cartwright, Thomas\|Tabernero, Josep\|Nowacki, Marek P\|Figer, Arie\|Maroun, Jean\|Price, Timothy\|Lim, Robert\|Van Cutsem, Eric\|Park, Young-Suk\|McKendrick, Joseph\|Topham, Claire\|Soler-Gonzalez, Gemma\|de Braud, Filipo\|Hill, Mark\|Sirzen, Flo
PMID:	17194911

7.
Journal:	Clin Cancer Res. 2007 Feb 1;13(3):1000-9.
Title:	Clinical pharmacodynamic effects of the growth hormone receptor antagonist pegvisomant: implications for cancer therapy.
Author:	Yin, Donghua\|Vreeland, Franzanne\|Schaaf, Larry J\|Millham, Robert\|Duncan, Barbara A\|Sharma, Amarnath
PMID:	17289896

8.
Journal:	Ann Oncol. 2008 Feb;19(2):332-9. Epub 2007 Nov 6.
Title:	A phase Ib dose-escalation study of erlotinib, capecitabine and oxaliplatin in metastatic colorectal cancer patients.
Author:	Van Cutsem, E\|Verslype, C\|Beale, P\|Clarke, S\|Bugat, R\|Rakhit, A\|Fettner, S H\|Brennscheidt, U\|Feyereislova, A\|Delord, J-P
PMID:	17986625

9.
Journal:	Invest New Drugs. 2008 Oct;26(5):483-8.
Title:	Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer.
Author:	Vansteenkiste, Johan\|Van Cutsem, Eric\|Dumez, Herlinde\|Chen, Cong\|Ricker, Justin L\|Randolph, Sophia S\|Schoffski, Patrick
PMID:	18425418

10.
Journal:	J Clin Oncol. 2008 May 1;26(13):2118-23.
Title:	Potential regional differences for the tolerability profiles of fluoropyrimidines.
Author:	Haller, Daniel G\|Cassidy, Jim\|Clarke, Stephen J\|Cunningham, David\|Van Cutsem, Eric\|Hoff, Paulo M\|Rothenberg, Mace L\|Saltz, Leonard B\|Schmoll, Hans-Joachim\|Allegra, Carmen\|Bertino, Joseph R\|Douillard, Jean-Yves\|Gustavsson, Bengt G\|Milano, Gerard\|O'Connell,
PMID:	18445840

11.
Journal:	Clin Colorectal Cancer. 2008 Jul;7(4):273-9.
Title:	A phase II study of cetuximab/irinotecan in patients with heavily pretreated metastatic colorectal cancer: predictive value of early specific toxicities.
Author:	Gamucci, Teresa\|Nelli, Fabrizio\|Cianci, Giovanni\|Grassi, Giulia\|Moscetti, Luca\|Sperduti, Isabella\|Zeuli, Massimo\|Cortesi, Enrico\|D'Auria, Giuliana\|Pollera, Camillo Francesco
PMID:	18650196

12.
Journal:	Oncol Rep. 2009 Apr;21(4):1061-6.
Title:	Clinical comparison of QOL and adverse events during postoperative adjuvant chemotherapy in outpatients with node-positive colorectal cancer or gastric cancer.
Author:	Mukai, Masaya\|Kishima, Kyoko\|Uchiumi, Fumino\|Ishibashi, Emi\|Fukasawa, Maki\|Tajima, Takayuki\|Nakamura, Masato\|Makuuchi, Hiroyasu
PMID:	19288009

13.
Journal:	Qual Life Res. 2009 Oct;18(8):1095-103.
Title:	Health utility scores of colorectal cancer based on societal preference in Japan.
Author:	Shiroiwa, Takeru\|Fukuda, Takashi\|Tsutani, Kiichiro
PMID:	19626462

14.
Journal:	J Clin Oncol. 2010 Jul 20;28(21):3485-90.
Title:	Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer.
Author:	Chung, Ki Y\|Gore, Ira\|Fong, Lawrence\|Venook, Alan\|Beck, Stephen B\|Dorazio, Prudence\|Criscitiello, Peggy J\|Healey, Diane I\|Huang, Bo\|Gomez-Navarro, Jesus\|Saltz, Leonard B
PMID:	20498386

15.
Journal:	Cancer Cell. 2011 Jan 18;19(1):125-37.
Title:	Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling.
Author:	Sonoshita, Masahiro\|Aoki, Masahiro\|Fuwa, Haruhiko\|Aoki, Koji\|Hosogi, Hisahiro\|Sakai, Yoshiharu\|Hashida, Hiroki\|Takabayashi, Arimichi\|Sasaki, Makoto\|Robine, Sylvie\|Itoh, Kazuyuki\|Yoshioka, Kiyoko\|Kakizaki, Fumihiko\|Kitamura, Takanori\|Oshima, Masanobu\|Taket
PMID:	21251616

16.
Journal:	Anticancer Res. 2011 Jun;31(6):2271-81.
Title:	Phase II trial of weekly alternating sequential BIBF 1120 and afatinib for advanced colorectal cancer.
Author:	Bouche, Olivier\|Maindrault-Goebel, Frederique\|Ducreux, Michel\|Lledo, Gerard\|Andre, Thierry\|Stopfer, Peter\|Amellal, Nadia\|Merger, Michael\|De Gramont, Aimery
PMID:	21737652

17.
Journal:	J Clin Oncol. 2011 Oct 1;29(28):3783-90.
Title:	Phase I pharmacokinetic and pharmacodynamic dose-escalation study of RG7160 (GA201), the first glycoengineered monoclonal antibody against the epidermal growth factor receptor, in patients with advanced solid tumors.
Author:	Paz-Ares, Luis G\|Gomez-Roca, Carlos\|Delord, Jean-Pierre\|Cervantes, Andres\|Markman, Ben\|Corral, Jesus\|Soria, Jean-Charles\|Berge, Yann\|Roda, Desamparados\|Russell-Yarde, Fiona\|Hollingsworth, Simon\|Baselga, Jose\|Umana, Pablo\|Manenti, Luigi\|Tabernero, Josep
PMID:	21900113

18.
Journal:	Br J Cancer. 2011 Nov 22;105(11):1646-53.
Title:	Clinical activity of patupilone in patients with pretreated advanced/metastatic colon cancer: results of a phase I dose escalation trial.
Author:	Melichar, B\|Casado, E\|Bridgewater, J\|Bennouna, J\|Campone, M\|Vitek, P\|Delord, J-P\|Cerman, J Jr\|Salazar, R\|Dvorak, J\|Sguotti, C\|Urban, P\|Viraswami-Appanna, K\|Tan, E\|Tabernero, J
PMID:	22027708

19.
Journal:	Ann Oncol. 2012 Apr;23(4):933-41.
Title:	Cediranib in combination with mFOLFOX6 in Japanese patients with metastatic colorectal cancer: results from the randomised phase II part of a phase I/II study.
Author:	Kato, T\|Muro, K\|Yamaguchi, K\|Bando, H\|Hazama, S\|Amagai, K\|Baba, H\|Denda, T\|Shi, X\|Fukase, K\|Skamoto, J\|Mishima, H
PMID:	21828378

20.
Journal:	J Clin Oncol. 2012 Jul 1;30(19):2334-9.
Title:	Benefits and adverse events in younger versus older patients receiving adjuvant chemotherapy for colon cancer: findings from the Adjuvant Colon Cancer Endpoints data set.
Author:	Hubbard, Joleen\|Thomas, David M\|Yothers, Greg\|Green, Erin\|Blanke, Charles\|O'Connell, Michael J\|Labianca, Roberto\|Shi, Qian\|Bleyer, Archie\|de Gramont, Aimery\|Sargent, Daniel
PMID:	22614981

21.
Journal:	Drug Saf. 2012 Jun 1;35(6):507-18.
Title:	Novel adverse events of bevacizumab in the US FDA adverse event reporting system database: a disproportionality analysis.
Author:	Shamloo, Behrooz K\|Chhabra, Pankdeep\|Freedman, Andrew N\|Potosky, Arnold\|Malin, Jennifer\|Weiss Smith, Sheila
PMID:	22612854

22.
Journal:	Clin Cancer Res. 2012 May 1;18(9):2658-67.
Title:	A phase I dose-escalation study of regorafenib (BAY 73-4506), an inhibitor of oncogenic, angiogenic, and stromal kinases, in patients with advanced solid tumors.
Author:	Mross, Klaus\|Frost, Annette\|Steinbild, Simone\|Hedbom, Susanne\|Buchert, Martin\|Fasol, Ulrike\|Unger, Clemens\|Kratzschmar, Jorn\|Heinig, Roland\|Boix, Oliver\|Christensen, Olaf
PMID:	22421192

23.
Journal:	Br J Cancer. 2012 Mar 27;106(7):1268-73.
Title:	Safety of UFT/LV and S-1 as adjuvant therapy for stage III colon cancer in phase III trial: ACTS-CC trial.
Author:	Mochizuki, I\|Takiuchi, H\|Ikejiri, K\|Nakamoto, Y\|Kinugasa, Y\|Takagane, A\|Endo, T\|Shinozaki, H\|Takii, Y\|Takahashi, Y\|Mochizuki, H\|Kotake, K\|Kameoka, S\|Takahashi, K\|Watanabe, T\|Watanabe, M\|Boku, N\|Tomita, N\|Matsubara, Y\|Sugihara, K
PMID:	22415232

24.
Journal:	Transl Oncol. 2012 Feb;5(1):32-8. Epub 2012 Feb 1.
Title:	First clinical experience with the magnetic resonance imaging contrast agent and superoxide dismutase mimetic mangafodipir as an adjunct in cancer chemotherapy-a translational study.
Author:	Karlsson, Jan Olof G\|Adolfsson, Karin\|Thelin, Bo\|Jynge, Per\|Andersson, Rolf Gg\|Falkmer, Ursula G
PMID:	22348174

25.
Journal:	Cancer. 2012 Sep 1;118(17):4309-20.
Title:	Comparison of adverse events during 5-fluorouracil versus 5-fluorouracil/oxaliplatin adjuvant chemotherapy for stage III colon cancer: a population-based analysis.
Author:	Sanoff, Hanna K\|Carpenter, William R\|Freburger, Janet\|Li, Ling\|Chen, Kun\|Zullig, Leah L\|Goldberg, Richard M\|Schymura, Maria J\|Schrag, Deborah
PMID:	22294436

26.
Journal:	Cancer. 2013 Mar 1;119(5):1106-12.
Title:	Gene polymorphisms predict toxicity to neoadjuvant therapy in patients with rectal cancer.
Author:	Duldulao, Marjun P\|Lee, Wendy\|Nelson, Rebecca A\|Ho, Joyce\|Le, Maithao\|Chen, Zhenbin\|Li, Wenyan\|Kim, Joseph\|Garcia-Aguilar, Julio
PMID:	23096768

27.
Journal:	Cancer Chemother Pharmacol. 2013 Jan;71(1):257-64.
Title:	XELOX and bevacizumab followed by single-agent bevacizumab as maintenance therapy as first-line treatment in elderly patients with advanced colorectal cancer: the boxe study.
Author:	Rosati, Gerardo\|Avallone, Antonio\|Aprile, Giuseppe\|Butera, Alfredo\|Reggiardo, Giorgio\|Bilancia, Domenico
PMID:	23100174

28.
Journal:	Cancer Chemother Pharmacol. 2013 Feb;71(2):321-30.
Title:	A phase I trial of imatinib in combination with mFOLFOX6-bevacizumab in patients with advanced colorectal cancer.
Author:	Michael, M\|Zalcberg, J\|Gibbs, P\|Lipton, L\|Gouillou, M\|Jefford, M\|McArthur, G\|Copeman, M\|Lynch, K\|Tebbutt, N C
PMID:	23108698

29.
Journal:	Anticancer Res. 2013 May;33(5):2077-83.
Title:	Transarterial chemoembolization using DEBIRI for treatment of hepatic metastases from colorectal cancer.
Author:	Narayanan, Govindarajan\|Barbery, Katuzka\|Suthar, Rekha\|Guerrero, Gabriella\|Arora, Geetika
PMID:	23645758

30.
Journal:	BMJ Open. 2013 Jul 19;3(7). pii: bmjopen-2013-003034.
Title:	A pilot study on record reviewing with a priori patient selection.
Author:	Cihangir, Sezgin\|Borghans, Ine\|Hekkert, Karin\|Muller, Hein\|Westert, Gert\|Kool, Rudolf B
PMID:	23872292

31.
Journal:	Zhonghua Zhong Liu Za Zhi. 2013 Apr;35(4):268-72.
Title:	[Impact of CCND1 A870G polymorphism on acute adverse events in postoperative rectal cancer patients treated with adjuvant concurrent chemoradiotherapy].
Author:	Qiao, Yan\|Ren, Hua\|Huang, Ying\|DU, Zhong-li\|Yu, Dian-ke\|Jin, Jing\|Li, Ye-xiong\|Lin, Dong-xin\|Tan, Wen
PMID:	23985254

32.
Journal:	Clin Colorectal Cancer. 2013 Dec;12(4):248-54.
Title:	A phase 1B study of dulanermin in combination with modified FOLFOX6 plus bevacizumab in patients with metastatic colorectal cancer.
Author:	Wainberg, Zev A\|Messersmith, Wells A\|Peddi, Parvin F\|Kapp, Amy V\|Ashkenazi, Avi\|Royer-Joo, Stephanie\|Portera, Chia C\|Kozloff, Mark F
PMID:	24075777

33.
Journal:	Curr Oncol. 2013 Oct;20(5):247-51.
Title:	Bevacizumab-based therapy for colorectal cancer: experience from a large Canadian cohort at the Jewish General Hospital between 2004 and 2009.
Author:	Bouganim, N\|Mamo, A\|Wasserman, D W\|Batist, G\|Metrakos, P\|Chaudhury, P\|Hassanain, M\|Kavan, P
PMID:	24155628

34.
Journal:	Hepatogastroenterology. 2014 Jun;61(132):1018-23.
Title:	A Multicenter Feasibility Study with S-1, Oxaliplatin and Oral Leucovorin (SOL) for the Patients with Untreated Metastatic Colorectal Cancer: The Result of Final Analysis.
Author:	Lu, Ming\|Wang, Yan\|Liu, Wei\|Bai, Chunmei\|Xu, Jianming\|Shen, Lin
PMID:	26158159

35.
Journal:	J Natl Cancer Inst. 2014 Nov 7;106(12). pii: dju298.
Title:	DPYD variants as predictors of 5-fluorouracil toxicity in adjuvant colon cancer treatment (NCCTG N0147).
Author:	Lee, Adam M\|Shi, Qian\|Pavey, Emily\|Alberts, Steven R\|Sargent, Daniel J\|Sinicrope, Frank A\|Berenberg, Jeffrey L\|Goldberg, Richard M\|Diasio, Robert B
PMID:	25381393

36.
Journal:	Clin Transl Oncol. 2014 Nov;16(11):942-53.
Title:	Clinical management of regorafenib in the treatment of patients with advanced colorectal cancer.
Author:	Sastre, J\|Argiles, G\|Benavides, M\|Feliu, J\|Garcia-Alfonso, P\|Garcia-Carbonero, R\|Gravalos, C\|Guillen-Ponce, C\|Martinez-Villacampa, M\|Pericay, C
PMID:	25223744

37.
Journal:	BMC Cancer. 2014 Jul 11;14:510.
Title:	Vascular effects, efficacy and safety of nintedanib in patients with advanced, refractory colorectal cancer: a prospective phase I subanalysis.
Author:	Mross, Klaus\|Buchert, Martin\|Frost, Annette\|Medinger, Michael\|Stopfer, Peter\|Studeny, Matus\|Kaiser, Rolf
PMID:	25012508

38.
Journal:	J Geriatr Oncol. 2014 Jul;5(3):230-7.
Title:	Hospital-based health care use correlates with incidence of adverse events among elderly Medicare patients treated in adjuvant chemotherapy trials (Alliance 70802).
Author:	Lamont, Elizabeth B\|Yu, Menggang\|He, Yulei\|Saltz, Leonard\|Muss, Hyman\|Zaslavsky, Alan M
PMID:	24594119

39.
Journal:	Invest New Drugs. 2014 Aug;32(4):653-60.
Title:	A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors.
Author:	Weekes, Colin D\|Beeram, Muralidhar\|Tolcher, Anthony W\|Papadopoulos, Kyriakos P\|Gore, Lia\|Hegde, Priti\|Xin, Yan\|Yu, Ron\|Shih, L Mason\|Xiang, Hong\|Brachmann, Rainer K\|Patnaik, Amita
PMID:	24604265

40.
Journal:	Acta Radiol. 2014 Sep;55(7):793-801.
Title:	Negative-balance isolated pelvic perfusion in patients with incurable symptomatic rectal cancer: results and drug dose correlation to adverse events.
Author:	Murata, Satoru\|Onozawa, Shiro\|Kim, Chol\|Tajima, Hiroyuki\|Kimata, Ryoji\|Uchida, Eiji\|Kumita, Shin-Ichiro
PMID:	24097815

41.
Journal:	Cancer Chemother Pharmacol. 2014 Mar;73(3):467-73.
Title:	Phase 1b study of safety, tolerability and efficacy of R1507, a monoclonal antibody to IGF-1R in combination with multiple standard oncology regimens in patients with advanced solid malignancies.
Author:	Mahadevan, Daruka\|Sutton, Gregory Ryan\|Arteta-Bulos, Rafael\|Bowden, Chris J\|Miller, Paul J E\|Swart, Rachel Elizabeth\|Walker, Mark S\|Haluska, Paul\|Munster, Pamela N\|Marshall, John\|Hamid, Omid\|Kurzrock, Razelle
PMID:	24390424

42.
Journal:	Asian Pac J Cancer Prev. 2014 Jan;14(11):6585-90.
Title:	Efficacy and tolerability of adjuvant oral capecitabine plus intravenous oxaliplatin (XELOX) in Asian patients with colorectal cancer: 4-year analysis.
Author:	Chiu, Joanne\|Tang, Vikki\|Leung, Roland\|Wong, Hilda\|Chu, Kin Wah\|Poon, Jensen\|Epstein, Richard J\|Yau, Thomas
PMID:	24377572

43.
Journal:	Crit Rev Oncol Hematol. 2015 Nov;96(2):355-71.
Title:	Risk of grade 3-4 diarrhea and mucositis in colorectal cancer patients receiving anti-EGFR monoclonal antibodies regimens: A meta-analysis of 18 randomized controlled clinical trials.
Author:	Miroddi, Marco\|Sterrantino, Carmelo\|Simonelli, Ilaria\|Ciminata, Giorgio\|Phillips, Robert S\|Calapai, Gioacchino
PMID:	26160607

44.
Journal:	BMC Cancer. 2015 Oct 24;15:786.
Title:	Capecitabine and oxaliplatin combined with bevacizumab are feasible for treating selected Japanese patients at least 75 years of age with metastatic colorectal cancer.
Author:	Munemoto, Yoshinori\|Kanda, Mitsuro\|Ishibashi, Keiichiro\|Hata, Taishi\|Kobayashi, Michiya\|Hasegawa, Junichi\|Fukunaga, Mutsumi\|Takagane, Akinori\|Otsuji, Toshio\|Miyake, Yasuhiro\|Nagase, Michitaka\|Sakamoto, Junichi\|Matsuoka, Masaki\|Oba, Koji\|Mishima, Hideyuki
PMID:	26497654

45.
Journal:	Invest New Drugs. 2015 Dec;33(6):1225-31.
Title:	A phase I trial of mFOLFOX6 combined with the oral PI3K inhibitor BKM120 in patients with advanced refractory solid tumors.
Author:	McRee, Autumn J\|Sanoff, Hanna K\|Carlson, Cheryl\|Ivanova, Anastasia\|O'Neil, Bert H
PMID:	26490655

46.
Journal:	Asia Pac J Clin Oncol. 2015 Dec;11(4):334-42.
Title:	Oxaliplatin/5-fluorouracil-based adjuvant chemotherapy as a standard of care for colon cancer in clinical practice: Outcomes of the ACCElox registry.
Author:	Park, Young Suk\|Ji, Jiafu\|Zalcberg, John Raymond\|El-Serafi, Mostafa\|Buzaid, Antonio\|Ghosn, Marwan
PMID:	26471890

47.
Journal:	Oncologist. 2015 Nov;20(11):1261-5.
Title:	Single-Agent Panitumumab in Frail Elderly Patients With Advanced RAS and BRAF Wild-Type Colorectal Cancer: Challenging Drug Label to Light Up New Hope.
Author:	Pietrantonio, Filippo\|Cremolini, Chiara\|Aprile, Giuseppe\|Lonardi, Sara\|Orlandi, Armando\|Mennitto, Alessia\|Berenato, Rosa\|Antoniotti, Carlotta\|Casagrande, Mariaelena\|Marsico, Valentina\|Marmorino, Federica\|Cardellino, Giovanni Gerardo\|Bergamo, Francesca\|Tom
PMID:	26446234

48.
Journal:	Invest New Drugs. 2015 Oct;33(5):1078-85.
Title:	Phase 1 dose de-escalation trial of the endogenous folate [6R]-5,10-methylene tetrahydrofolate in combination with fixed-dose pemetrexed as neoadjuvant therapy in patients with resectable rectal cancer.
Author:	Gustavsson, Bengt\|Carlsson, Goran\|Swartling, Torbjorn\|Kurlberg, Goran\|Derwinger, Kristoffer\|Bjorkqvist, Hillevi\|Odin, Elisabeth\|Gibson, Fernando
PMID:	26189513

49.
Journal:	World J Gastroenterol. 2015 Jun 21;21(23):7281-8.
Title:	Bevacizumab plus XELOX as first-line treatment of metastatic colorectal cancer: The OBELIX study.
Author:	Antonuzzo, Lorenzo\|Giommoni, Elisa\|Pastorelli, Davide\|Latiano, Tiziana\|Pavese, Ida\|Azzarello, Domenico\|Aieta, Michele\|Pastina, Ilaria\|Di Fabio, Francesca\|Bertolini, Alessandro\|Corsi, Domenico Cristiano\|Mogavero, Selene\|Angelini, Valentina\|Pazzagli, Mario\|
PMID:	26109816

50.
Journal:	Clin Cancer Res. 2015 Jun 1;21(11):2462-70.
Title:	Safety and Pharmacokinetics/Pharmacodynamics of the First-in-Class Dual Action HER3/EGFR Antibody MEHD7945A in Locally Advanced or Metastatic Epithelial Tumors.
Author:	Juric, Dejan\|Dienstmann, Rodrigo\|Cervantes, Andres\|Hidalgo, Manuel\|Messersmith, Wells\|Blumenschein, George R Jr\|Tabernero, Josep\|Roda, Desamparados\|Calles, Antonio\|Jimeno, Antonio\|Wang, Xiaodong\|Bohorquez, Sandra Sanabria\|Leddy, Cecilia\|Littman, Catherine
PMID:	26034219

51.
Journal:	Br J Clin Pharmacol. 2015 Sep;80(3):581-8.
Title:	DPD and UGT1A1 deficiency in colorectal cancer patients receiving triplet chemotherapy with fluoropyrimidines, oxaliplatin and irinotecan.
Author:	Falvella, Felicia Stefania\|Cheli, Stefania\|Martinetti, Antonia\|Mazzali, Cristina\|Iacovelli, Roberto\|Maggi, Claudia\|Gariboldi, Manuela\|Pierotti, Marco Alessandro\|Di Bartolomeo, Maria\|Sottotetti, Elisa\|Mennitto, Roberta\|Bossi, Ilaria\|de Braud, Filippo\|Cleme
PMID:	25782327

52.
Journal:	Invest New Drugs. 2015 Apr;33(2):409-22.
Title:	A phase 1 dose escalation study of BI 831266, an inhibitor of Aurora kinase B, in patients with advanced solid tumors.
Author:	Dittrich, Christian\|Fridrik, Michael A\|Koenigsberg, Robert\|Lee, Chooi\|Goeldner, Rainer-Georg\|Hilbert, James\|Greil, Richard
PMID:	25529193

53.
Journal:	Eur J Cancer. 2015 Jan;51(1):18-26.
Title:	Time course of safety and efficacy of aflibercept in combination with FOLFIRI in patients with metastatic colorectal cancer who progressed on previous oxaliplatin-based therapy.
Author:	Ruff, Paul\|Ferry, David R\|Lakomy, Radek\|Prausova, Jana\|Van Hazel, Guy A\|Hoff, Paulo M\|Cunningham, David\|Arnold, Dirk\|Schmoll, Hans J\|Moiseyenko, Vladimir M\|McKendrick, Joseph J\|Ten Tije, Albert J\|Vishwanath, Raghu L\|Bhargava, Pankaj\|Chevalier, Soazig\|Maca
PMID:	25466509

54.
Journal:	Cancer Discov. 2015 Feb;5(2):198-211.
Title:	Promotion of colorectal cancer invasion and metastasis through activation of NOTCH-DAB1-ABL-RHOGEF protein TRIO.
Author:	Sonoshita, Masahiro\|Itatani, Yoshiro\|Kakizaki, Fumihiko\|Sakimura, Kenji\|Terashima, Toshio\|Katsuyama, Yu\|Sakai, Yoshiharu\|Taketo, M Mark
PMID:	25432929

55.
Journal:	Cancer Sci. 2016 Nov;107(11):1622-1631.
Title:	Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2.
Author:	Kakizaki, Fumihiko\|Sonoshita, Masahiro\|Miyoshi, Hiroyuki\|Itatani, Yoshiro\|Ito, Shinji\|Kawada, Kenji\|Sakai, Yoshiharu\|Taketo, M Mark
PMID:	27561171

56.
Journal:	J Clin Oncol. 2016 Oct 10;34(29):3562-3569.
Title:	Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors.
Author:	Naing, Aung\|Papadopoulos, Kyriakos P\|Autio, Karen A\|Ott, Patrick A\|Patel, Manish R\|Wong, Deborah J\|Falchook, Gerald S\|Pant, Shubham\|Whiteside, Melinda\|Rasco, Drew R\|Mumm, John B\|Chan, Ivan H\|Bendell, Johanna C\|Bauer, Todd M\|Colen, Rivka R\|Hong, David S\|Va
PMID:	27528724

57.
Journal:	Oncotarget. 2016 Sep 13;7(37):59087-59097.
Title:	Vorinostat and hydroxychloroquine improve immunity and inhibit autophagy in metastatic colorectal cancer.
Author:	Patel, Sukeshi\|Hurez, Vincent\|Nawrocki, Steffan T\|Goros, Martin\|Michalek, Joel\|Sarantopoulos, John\|Curiel, Tyler\|Mahalingam, Devalingam
PMID:	27463016

58.
Journal:	JAMA Oncol. 2016 Jan 21. pii: 2482915.
Title:	DPYD Genotyping to Predict Adverse Events Following Treatment With Flourouracil-Based Adjuvant Chemotherapy in Patients With Stage III Colon Cancer: A Secondary Analysis of the PETACC-8 Randomized Clinical Trial.
Author:	Boige, Valerie\|Vincent, Marc\|Alexandre, Philippe\|Tejpar, Sabine\|Landolfi, Stefania\|Le Malicot, Karine\|Greil, Richard\|Cuyle, Pieter Jan\|Yilmaz, Mette\|Faroux, Roger\|Matzdorff, Axel\|Salazar, Ramon\|Lepage, Come\|Taieb, Julien\|Laurent-Puig, Pierre
PMID:	26794347

59.
Journal:	Anticancer Drugs. 2016 Jun;27(5):457-63.
Title:	Efficacy and safety analysis of chemotherapy for advanced colitis-associated colorectal cancer in Japan.
Author:	Nio, Kenta\|Higashi, Daijiro\|Kumagai, Hozumi\|Arita, Shuji\|Shirakawa, Tsuyoshi\|Nakashima, Koji\|Shibata, Yoshihiro\|Esaki, Motohiro\|Manabe, Tatsuya\|Nagai, Shuntaro\|Ueki, Takashi\|Nakano, Michitaka\|Ariyama, Hiroshi\|Kusaba, Hitoshi\|Hirahashi, Minako\|Oda, Yoshina
PMID:	26771865

60.
Journal:	J Biochem. 2016 Jan;159(1):133-40.
Title:	Characterization of Aes nuclear foci in colorectal cancer cells.
Author:	Itatani, Yoshiro\|Sonoshita, Masahiro\|Kakizaki, Fumihiko\|Okawa, Katsuya\|Stifani, Stefano\|Itoh, Hideaki\|Sakai, Yoshiharu\|Taketo, M Mark
PMID:	26229111

61.
Journal:	Cancer Chemother Pharmacol. 2016 May;77(5):997-1003.
Title:	A first-in-Asian phase 1 study to evaluate safety, pharmacokinetics and clinical activity of VS-6063, a focal adhesion kinase (FAK) inhibitor in Japanese patients with advanced solid tumors.
Author:	Shimizu, Toshio\|Fukuoka, Kazuya\|Takeda, Masayuki\|Iwasa, Tutomu\|Yoshida, Takeshi\|Horobin, Joanna\|Keegan, Mitchell\|Vaickus, Lou\|Chavan, Ajit\|Padval, Mahesh\|Nakagawa, Kazuhiko
PMID:	27025608

62.
Journal:	PLoS One. 2017 Dec 28;12(12):e0189848.
Title:	Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with advanced colorectal carcinoma.
Author:	O'Neil, Bert H\|Wallmark, John M\|Lorente, David\|Elez, Elena\|Raimbourg, Judith\|Gomez-Roca, Carlos\|Ejadi, Samuel\|Piha-Paul, Sarina A\|Stein, Mark N\|Abdul Razak, Albiruni R\|Dotti, Katia\|Santoro, Armando\|Cohen, Roger B\|Gould, Marlena\|Saraf, Sanatan\|Stein, Karen
PMID:	29284010

63.
Journal:	Oncotarget. 2017 Jun 16;8(45):79546-79555.
Title:	Phase I dose-escalation study of the c-Met tyrosine kinase inhibitor SAR125844 in Asian patients with advanced solid tumors, including patients with MET-amplified gastric cancer.
Author:	Shitara, Kohei\|Kim, Tae Min\|Yokota, Tomoya\|Goto, Masahiro\|Satoh, Taroh\|Ahn, Jin-Hee\|Kim, Hyo Song\|Assadourian, Sylvie\|Gomez, Corinne\|Harnois, Marzia\|Hamauchi, Satoshi\|Kudo, Toshihiro\|Doi, Toshihido\|Bang, Yung-Jue
PMID:	29108334

64.
Journal:	Front Pharmacol. 2017 Sep 6;8:607.
Title:	Safety Profile of Anticancer and Immune-Modulating Biotech Drugs Used in a Real World Setting in Campania Region (Italy): BIO-Cam Observational Study.
Author:	Scavone, Cristina\|Sportiello, Liberata\|Sullo, Maria G\|Ferrajolo, Carmen\|Ruggiero, Rosanna\|Sessa, Maurizio\|Berrino, Pasquale M\|di Mauro, Gabriella\|Berrino, Liberato\|Rossi, Francesco\|Rafaniello, Concetta\|Capuano, Annalisa
PMID:	28932193

65.
Journal:	Cochrane Database Syst Rev. 2017 Jul 28;7:CD008398.
Title:	Oral versus intravenous fluoropyrimidines for colorectal cancer.
Author:	Chionh, Fiona\|Lau, David\|Yeung, Yvonne\|Price, Timothy\|Tebbutt, Niall
PMID:	28752564

66.
Journal:	Oncotarget. 2017 May 9;8(19):31112-31118.
Title:	The role of targeted agents in the adjuvant treatment of colon cancer: a meta-analysis of randomized phase III studies and review.
Author:	Kim, Bum Jun\|Jeong, Jae Ho\|Kim, Jung Han\|Kim, Hyeong Su\|Jang, Hyun Joo
PMID:	28415706

67.
Journal:	Cancer Sci. 2017 Apr;108(4):744-752.
Title:	Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancer.
Author:	Okada, Yoshiyuki\|Sonoshita, Masahiro\|Kakizaki, Fumihiko\|Aoyama, Naoki\|Itatani, Yoshiro\|Uegaki, Masayuki\|Sakamoto, Hiromasa\|Kobayashi, Takashi\|Inoue, Takahiro\|Kamba, Tomomi\|Suzuki, Akira\|Ogawa, Osamu\|Taketo, M Mark
PMID:	28178391

68.
Journal:	Br J Cancer. 2017 Feb 28;116(5):575-583.
Title:	A phase 1 dose-escalation and expansion study of binimetinib (MEK162), a potent and selective oral MEK1/2 inhibitor.
Author:	Bendell, Johanna C\|Javle, Milind\|Bekaii-Saab, Tanios S\|Finn, Richard S\|Wainberg, Zev A\|Laheru, Daniel A\|Weekes, Colin D\|Tan, Benjamin R\|Khan, Gazala N\|Zalupski, Mark M\|Infante, Jeffrey R\|Jones, Suzanne\|Papadopoulos, Kyriakos P\|Tolcher, Anthony W\|Chavira,
PMID:	28152546

69.
Journal:	Invest New Drugs. 2017 Feb;35(1):47-58.
Title:	A phase I dose-escalation study of TAK-733, an investigational oral MEK inhibitor, in patients with advanced solid tumors.
Author:	Adjei, Alex A\|LoRusso, Patricia\|Ribas, Antoni\|Sosman, Jeffrey A\|Pavlick, Anna\|Dy, Grace K\|Zhou, Xiaofei\|Gangolli, Esha\|Kneissl, Michelle\|Faucette, Stephanie\|Neuwirth, Rachel\|Bozon, Viviana
PMID:	27650277

70.
Journal:	Clin Colorectal Cancer. 2018 Jun;17(2):e153-e161.
Title:	Planned Safety Analysis of the ACTS-CC 02 Trial: A Randomized Phase III Trial of S-1 With Oxaliplatin Versus Tegafur and Uracil With Leucovorin as Adjuvant Chemotherapy for High-Risk Stage III Colon Cancer.
Author:	Kusumoto, Tetsuya\|Sunami, Eiji\|Ota, Mitsuyoshi\|Yoshida, Kazuhiro\|Sakamoto, Yoshiyuki\|Tomita, Naohiro\|Maeda, Atsuyuki\|Mochizuki, Izumi\|Okabe, Michio\|Kunieda, Katsuyuki\|Yamauchi, Junichiro\|Itabashi, Michio\|Kotake, Kenjiro\|Takahashi, Keiichi\|Baba, Hideo\|Boku
PMID:	29249584

71.
Journal:	Eur J Cancer Care (Engl). 2018 Mar;27(2):e12800.
Title:	Patient-reported symptoms and stepwise symptom management in patients on epidermal growth factor inhibitors: A retrospective, descriptive cohort study.
Author:	Koldenhof, J J\|Langenberg, M H G\|Witteveen, P O\|Teunissen, S C C M
PMID:	29314360

72.
Journal:	Int J Colorectal Dis. 2018 Jun;33(6):809-817.
Title:	Safety of mFOLFOX6/XELOX as adjuvant chemotherapy after curative resection of stage III colon cancer: phase II clinical study (The FACOS study).
Author:	Kosugi, Chihiro\|Koda, Keiji\|Ishibashi, Keiichiro\|Yoshimatsu, Kazuhiko\|Tanaka, Soichi\|Kato, Ryouji\|Kato, Hiroyuki\|Oya, Masatoshi\|Narushima, Kazuo\|Mori, Mikito\|Shuto, Kiyohiko\|Ishida, Hideyuki
PMID:	29484450

73.
Journal:	Int J Radiat Oncol Biol Phys. 2018 Mar 15;100(4):1026-1033.
Title:	Associations of Genetic Variations in MicroRNA Seed Regions With Acute Adverse Events and Survival in Patients With Rectal Cancer Receiving Postoperative Chemoradiation Therapy.
Author:	Huang, Ying\|Feng, Yanru\|Ren, Hua\|Zhang, Meng\|Li, Hongmin\|Qiao, Yan\|Feng, Ting\|Yang, Jie\|Wang, Weihu\|Wang, Shulian\|Liu, Yueping\|Song, Yongwen\|Li, Yexiong\|Jin, Jing\|Tan, Wen\|Lin, Dongxin
PMID:	29485044

74.
Journal:	J Immunother. 2018 Apr;41(3):141-150.
Title:	Whole Recombinant Saccharomyces cerevisiae Yeast Expressing Ras Mutations as Treatment for Patients With Solid Tumors Bearing Ras Mutations: Results From a Phase 1 Trial.
Author:	Cohn, Allen\|Morse, Michael A\|O'Neil, Bert\|Whiting, Samuel\|Coeshott, Claire\|Ferraro, John\|Bellgrau, Donald\|Apelian, David\|Rodell, Timothy C
PMID:	29528991

75.
Journal:	Int J Cancer. 2018 Sep 15;143(6):1530-1540.
Title:	Phase Ib/II study of safety and efficacy of low-dose decitabine-primed chemoimmunotherapy in patients with drug-resistant relapsed/refractory alimentary tract cancer.
Author:	Chen, Meixia\|Nie, Jing\|Liu, Yang\|Li, Xiang\|Zhang, Yan\|Brock, Malcolm V\|Feng, Kaichao\|Wu, Zhiqiang\|Li, Xiaolei\|Shi, Lu\|Li, Suxia\|Guo, Mingzhou\|Mei, Qian\|Han, Weidong
PMID:	29663379

76.
Journal:	Cell Physiol Biochem. 2018;46(3):1275-1285.
Title:	LncRNA HOTAIR is a Prognostic Biomarker for the Proliferation and Chemoresistance of Colorectal Cancer via MiR-203a-3p-Mediated Wnt/ss-Catenin Signaling Pathway.
Author:	Xiao, Zhigang\|Qu, Zhan\|Chen, Zhikang\|Fang, Zhixue\|Zhou, Ke\|Huang, Zhongcheng\|Guo, Xiong\|Zhang, Yang
PMID:	29680837

77.
Journal:	Drugs. 2018 Jul;78(11):1133-1144.
Title:	Regorafenib: A Review in Metastatic Colorectal Cancer.
Author:	Dhillon, Sohita
PMID:	29943375

78.
Journal:	Ann Oncol. 2018 Sep 1;29(9):1955-1963.
Title:	Nintedanib for the treatment of patients with refractory metastatic colorectal cancer (LUME-Colon 1): a phase III, international, randomized, placebo-controlled study.
Author:	Van Cutsem, E\|Yoshino, T\|Lenz, H J\|Lonardi, S\|Falcone, A\|Limon, M L\|Saunders, M\|Sobrero, A\|Park, Y S\|Ferreiro, R\|Hong, Y S\|Tomasek, J\|Taniguchi, H\|Ciardiello, F\|Stoehr, J\|Oum'Hamed, Z\|Vlassak, S\|Studeny, M\|Argiles, G
PMID:	30010751

79.
Journal:	Onco Targets Ther. 2018 Oct 2;11:6405-6414.
Title:	Adverse events risk associated with regorafenib in the treatment of advanced solid tumors: meta-analysis of randomized controlled trials.
Author:	Yin, Xiaonan\|Yin, Yuan\|Shen, Chaoyong\|Chen, Huijiao\|Wang, Jiang\|Cai, Zhaolun\|Chen, Zhixin\|Zhang, Bo
PMID:	30323618