Primary Site >> Esophagus Cancer

Gene >> ZHX2

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Ref: Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway.
PMID: 10763823
 Ref: Sorafenib inhibits MAPK-mediated proliferation in a Barrett's esophageal adenocarcinoma cell line.
PMID: 18840136
 Ref: BRAF mutations in advanced cancers: clinical characteristics and outcomes.
PMID: 22039425
 Ref: RAF-kinase inhibitor protein (RKIP) downregulation in esophageal cancer and its metastases.
PMID: 22460832
Ref: pERK activation in esophageal carcinomas: clinicopathological associations.
PMID: 22658382
Ref: Rab25 is a tumor suppressor gene with antiangiogenic and anti-invasive activities in esophageal squamous cell carcinoma.
PMID: 22991305
 Ref: [Roles of targeting Ras/Raf/MEK/ERK signaling pathways in the treatment of esophageal carcinoma].
PMID: 23888683
 Ref: RNA-seq reveals determinants of sensitivity to chemotherapy drugs in esophageal carcinoma cells.
PMID: 24817948
Ref: DADS suppresses human esophageal xenograft tumors through RAF/MEK/ERK and mitochondria-dependent pathways.
PMID: 25026173
Ref: Association between raf kinase inhibitor protein loss and prognosis in cancers of the digestive system: a meta-analysis.
PMID: 25171481
 Ref: Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer.
PMID: 26646323
 Ref: GE11 peptide conjugated selenium nanoparticles for EGFR targeted oridonin delivery to achieve enhanced anticancer efficacy by inhibiting EGFR-mediated PI3K/AKT and Ras/Raf/MEK/ERK pathways.
PMID: 29019267
 Ref: Oridonin-induced mitochondria-dependent apoptosis in esophageal cancer cells by inhibiting PI3K/AKT/mTOR and Ras/Raf pathways.
PMID: 30229997