Primary Site >> Colorectal Cancer
Gene >> XRCC1
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Ref: Inheritance of the 194Trp and the 399Gln variant alleles of the DNA repair gene XRCC1 are associated with increased risk of early-onset colorectal carcinoma in Egypt. PMID: 10974409 |
Ref: Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells. PMID: 11585361 Ref: A polymorphism of the XRCC1 gene predicts for response to platinum based treatment in advanced colorectal cancer. PMID: 11712813 |
Ref: Inhibition of base excision repair potentiates iododeoxyuridine-induced cytotoxicity and radiosensitization. PMID: 12591735 Ref: Lack of involvement of nucleotide excision repair gene polymorphisms in colorectal cancer. PMID: 12865926 |
Ref: [Report of the National Oncology Research and Developement Consortium, 2003]. PMID: 15105900 Ref: A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer. PMID: 15213713 Ref: An association of polymorphism of DNA repair genes XRCC1 and XRCC3 with colorectal cancer. PMID: 15354414 |
Ref: Polymorphisms of the XRCC1, XRCC3, & XPD genes, and colorectal cancer risk: a case-control study in Taiwan. PMID: 15679883 Ref: Polymorphisms of XRCC1 gene, alcohol consumption and colorectal cancer. PMID: 15800946 Ref: MS-920: DNA repair gene polymorphisms, diet and colorectal cancer risk in Taiwan. PMID: 15914278 |
Ref: Validation of the use of DNA pools and primer extension in association studies of sporadic colorectal cancer for selection of candidate SNPs. PMID: 16395669 Ref: Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study. PMID: 16542436 Ref: Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer. PMID: 16609022 Ref: Multiplex pyrosequencing of two polymorphisms in DNA repair gene XRCC1. PMID: 16931584 Ref: DNA repair pathway profiling and microsatellite instability in colorectal cancer. PMID: 16951227 Ref: Which gene is a dominant predictor of response during FOLFOX chemotherapy for the treatment of metastatic colorectal cancer, the MTHFR or XRCC1 gene? PMID: 17009149 |
Ref: Association between polymorphisms of biotransformation and DNA-repair genes and risk of colorectal cancer in Taiwan. PMID: 17191090 Ref: Combined analysis of genetic polymorphisms in thymidylate synthase, uridine diphosphate glucoronosyltransferase and X-ray cross complementing factor 1 genes as a prognostic factor in advanced colorectal cancer patients treated with 5-fluorouracil plus oxa PMID: 17273745 Ref: Genetic variation in base excision repair genes and the prevalence of advanced colorectal adenoma. PMID: 17283177 Ref: [Correlations of single nucleotide polymorphisms of DNA repair gene XRCC1 to risk of colorectal cancer]. PMID: 17355790 Ref: DNA repair pathways and mitochondrial DNA mutations in gastrointestinal carcinogenesis. PMID: 17397816 Ref: Sporadic colorectal cancer and individual susceptibility: a review of the association studies investigating the role of DNA repair genetic polymorphisms. PMID: 17419091 Ref: DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. PMID: 18006925 Ref: Tumors established with cell lines selected for oxaliplatin resistance respond to oxaliplatin if combined with cetuximab. PMID: 18094427 |
Ref: ERCC2 2251A>C genetic polymorphism was highly correlated with early relapse in high-risk stage II and stage III colorectal cancer patients: a preliminary study. PMID: 18267032 Ref: Irinotecan pharmacogenetics: influence of pharmacodynamic genes. PMID: 18347181 Ref: Pharmacogenetic approach for capecitabine or 5-fluorouracil selection to be combined with oxaliplatin as first-line chemotherapy in advanced colorectal cancer. PMID: 18448328 Ref: Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial. PMID: 18509181 Ref: Role of DNA repair systems in malignant tumor development in the elderly. PMID: 18713157 Ref: Pharmacogenetic prediction of clinical outcome in advanced colorectal cancer patients receiving oxaliplatin/5-fluorouracil as first-line chemotherapy. PMID: 18797464 Ref: No association between the Arg194Trp and Arg399Gln polymorphisms of the XRCC1 gene and colorectal cancer risk and progression in a Polish population. PMID: 18806752 Ref: Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population. PMID: 18823566 Ref: Polymorphisms of the DNA repair genes XRCC1 and XRCC3 and risk of lung and colorectal cancer: a case-control study in a Southern Italian population. PMID: 19031937 Ref: [Application of multifactor dimensionality reduction on the interactions between gene-gene, gene-environment and the risk sporadic colorectal cancer in Chinese population]. PMID: 19040031 |
Ref: Pharmacogenetics in chemotherapy of colorectal cancer. PMID: 19414151 Ref: [Genetic polymorphism in patients with colorectal and with head and neck cancer]. PMID: 19643719 Ref: Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: the FOCUS trial. PMID: 19858398 Ref: Assessing tumor mutations to gain insight into base excision repair sequence polymorphisms and smoking in colon cancer. PMID: 19959686 Ref: Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study. PMID: 20559012 |
Ref: The value of XPD and XRCC1 genotype polymorphisms to predict clinical outcome in metastatic colorectal carcinoma patients with irinotecan-based regimens. PMID: 19908066 Ref: A meta-analysis on XRCC1 and XRCC3 polymorphisms and colorectal cancer risk. PMID: 19915856 Ref: XRCC1 polymorphisms and risk of colorectal cancer: a meta-analysis. PMID: 20033188 Ref: Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and FOLFOX response in colorectal cancer patients. PMID: 20078613 Ref: Polymorphisms in DNA repair genes XRCC1, XRCC3 and XPD, and colorectal cancer risk: a case-control study in an Indian population. PMID: 20229274 Ref: Pharmacogenetic analysis in neoadjuvant chemoradiation for rectal cancer: high incidence of somatic mutations and their relation with response. PMID: 20504250 Ref: Association between single-nucleotide polymorphisms of selected genes involved in the response to DNA damage and risk of colon, head and neck, and breast cancers in a Polish population. PMID: 20720310 Ref: XRCC1 gene polymorphism for prediction of response and prognosis in the multimodality therapy of patients with locally advanced rectal cancer. PMID: 20863523 Ref: Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat. PMID: 21037106 |
Ref: Tumor response is predicted by patient genetic profile in rectal cancer patients treated with neo-adjuvant chemo-radiotherapy. PMID: 20368715 Ref: Role of genetic polymorphisms and mutations in colorectal cancer therapy (Review). PMID: 21468552 Ref: Association of APE1 and hOGG1 polymorphisms with colorectal cancer risk in a Turkish population. PMID: 21561390 Ref: Pharmacogenetic study in rectal cancer patients treated with preoperative chemoradiotherapy: polymorphisms in thymidylate synthase, epidermal growth factor receptor, GSTP1, and DNA repair genes. PMID: 21570215 Ref: No association of XRCC1 polymorphisms Arg194Trp and Arg399Gln with colorectal cancer risk. PMID: 21612998 Ref: Pharmacokinetic and metabolism determinants of fluoropyrimidines and oxaliplatin activity in treatment of colorectal patients. PMID: 21787270 Ref: Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk of gastric and colorectal cancer in Turkish population. PMID: 21971103 Ref: Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil. PMID: 22194930 |
Ref: X-ray cross-complementing group 1 and thymidylate synthase polymorphisms might predict response to chemoradiotherapy in rectal cancer patients. PMID: 21167658 Ref: The C/A polymorphism in intron 11 of the XPC gene plays a crucial role in the modulation of an individual's susceptibility to sporadic colorectal cancer. PMID: 21559836 Ref: DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome. PMID: 21974800 Ref: Genetic polymorphisms of XRCC1, alcohol consumption, and the risk of colorectal cancer in Japan. PMID: 22186158 Ref: Tumor growth is suppressed in mice expressing a truncated XRCC1 protein. PMID: 22432057 Ref: Genetic polymorphisms of DNA repair genes XRCC1 and XRCC3 and risk of colorectal cancer in Chinese population. PMID: 22524842 Ref: Genetic polymorphism of XRCC1 correlated with response to oxaliplatin-based chemotherapy in advanced colorectal cancer. PMID: 22549274 Ref: ERCC1 C118T associates with response to FOLFOX4 chemotherapy in colorectal cancer patients in Han Chinese. PMID: 22567180 Ref: Prediction of genetic polymorphisms of DNA repair genes XRCC1 and XRCC3 in the survival of colorectal cancer receiving chemotherapy in the Chinese population. PMID: 22580644 Ref: MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer. PMID: 22843073 Ref: Pharmacogenetic markers of toxicity for chemotherapy in colorectal cancer patients. PMID: 22909207 Ref: Association between polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln genes and prognosis of colorectal cancer in a Chinese population. PMID: 23317245 |
Ref: Gene polymorphisms predict toxicity to neoadjuvant therapy in patients with rectal cancer. PMID: 23096768 Ref: X-ray repair cross-complementing group 1 Arg399Gln gene polymorphism and susceptibility to colorectal cancer:a meta-analysis. PMID: 23188703 Ref: Meta-analysis of the association between the XRCC1 gene R399Q polymorphism and colorectal cancer: an update. PMID: 23233244 Ref: Association between XRCC1 and XRCC3 polymorphisms and colorectal cancer risk: a meta-analysis of 23 case-control studies. PMID: 23271134 Ref: XRCC1 and GSTP1 polymorphisms and prognosis of oxaliplatin-based chemotherapy in colorectal cancer: a meta-analysis. PMID: 23299794 Ref: Pharmacogenetic analysis of adjuvant FOLFOX for Korean patients with colon cancer. PMID: 23314736 Ref: Genetic polymorphism of XRCC1 correlated with response to oxaliplatin-based chemotherapy in advanced colorectal cancer. PMID: 23327191 Ref: Letter to the editor: Obvious association between XRCC1 Arg399Gln polymorphism and colorectal cancer in East Asians. PMID: 23334690 Ref: Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study. PMID: 23426866 Ref: Polymorphisms in genes of APE1, PARP1, and XRCC1: risk and prognosis of colorectal cancer in a northeast Chinese population. PMID: 23430444 Ref: Differential toxicity biomarkers for irinotecan- and oxaliplatin-containing chemotherapy in colorectal cancer. PMID: 23543295 Ref: An association selected polymorphisms of XRCC1, OGG1 and MUTYH gene and the level of efficiency oxidative DNA damage repair with a risk of colorectal cancer. PMID: 23618615 Ref: The influence of XPD, APE1, XRCC1, and NBS1 polymorphic variants on DNA repair in cells exposed to X-rays. PMID: 23669291 Ref: XRCC1 Arg399Gln polymorphism contributes to increased risk of colorectal cancer in Chinese population. PMID: 23712778 Ref: Association between X-ray repair cross-complementing group 1 Arg194Trp polymorphism and colorectal cancer risk. PMID: 23857281 Ref: Tumor site- and stage-specific associations between allelic variants of glutathione S-transferase and DNA-repair genes and overall survival in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. PMID: 23894404 Ref: Predictive value of ERCC1, ERCC2, and XRCC1 overexpression for stage III colorectal cancer patients receiving FOLFOX-4 adjuvant chemotherapy. PMID: 23996617 Ref: Lys751Gln XPD and Arg399Gln XRCC1 in Romanians. Association with sporadic colorectal cancer risk and different stages of carcinomas. PMID: 24157118 Ref: Genes and SNPs associated with non-hereditary and hereditary colorectal cancer. PMID: 24289550 Ref: Statement of retraction: Hongying Lv, Qicai Li, Wengsheng Qiu, Jinyu Xiang, Hongjun Wei, Hua Liang, Aihua Sui and Jun Liang "Genetic polymorphism of XRCC1 correlated with response to oxaliplatin-based chemotherapy in advanced colorectal cancer". PMID: 24328669 Ref: [Correlation of single nucleotide polymorphisms of X-ray repair cross complementing group 1 gene to hereditary susceptibility of colorectal cancer]. PMID: 24369405 Ref: The XRCC1 Arg399Gln gene polymorphism and risk of colorectal cancer: a study in Kashmir. PMID: 24377605 |
Ref: X-ray repair cross-complementing 1 polymorphism and prognosis of platinum-based chemotherapy in gastric and colorectal cancer: a meta-analysis. PMID: 24224851 Ref: Pretreatment selection of regimen according to genetic analysis improves the efficacy of chemotherapy in the first line treatment of metastatic colorectal cancer. PMID: 24318863 Ref: Polymorphisms in XRCC1 gene, alcohol drinking, and risk of colorectal cancer: a case-control study in Jiangsu Province of China. PMID: 24377576 Ref: Identification of an endoplasmic reticulum membrane protein interacting with DNA polymerase beta by a yeast two-hybrid screen. PMID: 24772827 Ref: ERCC1, XRCC1 and GSTP1 Single Nucleotide Polymorphisms and Survival of Patients with Colon Cancer Receiving Oxaliplatin-Based Adjuvant Chemotherapy. PMID: 24847383 Ref: APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans. PMID: 25024628 Ref: XRCC1 gene polymorphism, diet and risk of colorectal cancer in Thailand. PMID: 25227862 Ref: Effect of APE1 T2197G (Asp148Glu) polymorphism on APE1, XRCC1, PARP1 and OGG1 expression in patients with colorectal cancer. PMID: 25268610 Ref: Genetic markers for toxicity of adjuvant oxaliplatin and fluoropyrimidines in the phase III TOSCA trial in high-risk colon cancer patients. PMID: 25370899 Ref: Phase 1/2 study of valproic acid and short-course radiotherapy plus capecitabine as preoperative treatment in low-moderate risk rectal cancer-V-shoRT-R3 (Valproic acid--short Radiotherapy--rectum 3rd trial). PMID: 25421252 |
Ref: XRCC1 R399Q polymorphism and colorectal cancer risk in the Chinese Han population: a meta-analysis. PMID: 25582318 Ref: Germline TYMS genotype is highly predictive in patients with metastatic gastrointestinal malignancies receiving capecitabine-based chemotherapy. PMID: 25677447 Ref: DNA repair gene polymorphisms do not predict response to radiotherapy-based multimodality treatment of patients with rectal cancer: a meta-analysis. PMID: 25684513 Ref: XRCC1 and ERCC1 polymorphisms are related to susceptibility and survival of colorectal cancer in the Chinese population. PMID: 25690281 Ref: Germ line polymorphisms as predictive markers for pre-surgical radiochemotherapy in locally advanced rectal cancer: a 5-year literature update and critical review. PMID: 25740678 Ref: Association of XRCC1 Arg399Gln Polymorphism with Colorectal Cancer Risk: A HuGE Meta Analysis of 35 Studies. PMID: 25921133 Ref: Genetic polymorphisms in XRCC1 genes and colorectal cancer susceptibility. PMID: 26271249 Ref: Polymorphism of the DNA Repair Gene XRCC1 (Arg194Trp) and its role in Colorectal Cancer in Kashmiri Population: a Case Control Study. PMID: 26434847 |
Ref: Variant Alleles in XRCC1 Arg194Trp and Arg399Gln Polymorphisms Increase Risk of Gastrointestinal Cancer in Sabah, North Borneo. PMID: 27221877 Ref: Lack of Association between an XRCC1 Gene Polymorphism and Colorectal Cancer Survival in Thailand. PMID: 27221895 Ref: Gene polymorphism in DNA repair genes XRCC1 and XRCC6 and association with colorectal cancer in Swedish patients. PMID: 27328741 Ref: Pharmacogenetic and ethnicity influence on oxaliplatin therapy for colorectal cancer: a meta-analysis. PMID: 27636246 Ref: DNA repair genes polymorphisms and risk of colorectal cancer in Saudi patients. PMID: 27686263 Ref: Focusing the management of rectal cancer. PMID: 28149883 Ref: X-ray cross-complementing groups 1 rs1799782 C>T polymorphisms and colorectal cancer susceptibility: A meta-analysis based on Chinese Han population. PMID: 28230032 |
Ref: Potential Role of Single Nucleotide Polymorphisms of XRCC1, XRCC3, and RAD51 in Predicting Acute Toxicity in Rectal Cancer Patients Treated With Preoperative Radiochemotherapy. PMID: 25811296 Ref: Lack of correlation between X-ray repair cross-complementing group 1 gene polymorphisms and the susceptibility to colorectal cancer in a Malaysian cohort. PMID: 28059856 Ref: Single Nucleotide Polymorphism TGFbeta1 R25P Correlates with Acute Toxicity during Neoadjuvant Chemoradiotherapy in Rectal Cancer Patients. PMID: 28333014 Ref: Colorectal Cancer Carcinogenesis: a Multivariate Genetic Model in a Cohort of Romanian Population. PMID: 28397463 Ref: Relationship Between Expression of Proteins ERCC1, ERCC2, and XRCC1 and Clinical Outcomes in Patients with Rectal Cancer Treated with FOLFOX-Based Preoperative Chemoradiotherapy. PMID: 28608017 Ref: XRCC1 Gene Polymorphisms and miR-21 Expression in Patients with Colorectal Carcinoma. PMID: 28638257 Ref: Inhibition of B7-H3 reverses oxaliplatin resistance in human colorectal cancer cells. PMID: 28676400 Ref: Role of depth of response and MTHFR genotype as predictors of fluorouracil rechallenge therapy for refractory metastatic colorectal cancer. PMID: 28781687 Ref: Base excision repair imbalance in colorectal cancer has prognostic value and modulates response to chemotherapy. PMID: 28903334 Ref: Effect of AICAR and 5-Fluorouracil on X-ray Repair, Cross-Complementing Group 1 Expression, and Consequent Cytotoxicity Regulation in Human HCT-116 Colorectal Cancer Cells. PMID: 29117108 Ref: Correlations between microsatellite instability, ERCC1/XRCC1 polymorphism and clinical characteristics, and FOLFOX adjuvant chemotherapy effect of colorectal cancer patients. PMID: 29153096 Ref: Analysis of 12 variants in the development of gastric and colorectal cancers. PMID: 29358861 |
Ref: Prognostic impact of changes in base excision repair machinery in sporadic colorectal cancer. PMID: 29254784 Ref: The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis. PMID: 29721061 Ref: Pharmacogenetic analyses of 2183 patients with advanced colorectal cancer; potential role for common dihydropyrimidine dehydrogenase variants in toxicity to chemotherapy. PMID: 30114658 Ref: Single nucleotide polymorphism of PMID: 30309213 |