Primary Site >> Colorectal Cancer
Gene >> WNT5A
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Ref: Frequent up-regulation of WNT5A mRNA in primary gastric cancer. PMID: 11956659 Ref: Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma. PMID: 12147710 |
Ref: The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer. PMID: 15592505 Ref: Comparative genomics on ROR1 and ROR2 orthologs. PMID: 16211313 Ref: Wnt-5a protein expression in primary dukes B colon cancers identifies a subgroup of patients with good prognosis. PMID: 16230369 |
Ref: Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. PMID: 16439479 Ref: Comparative integromics on FAT1, FAT2, FAT3 and FAT4. PMID: 16865240 |
Ref: Regulation of norrin receptor frizzled-4 by Wnt2 in colon-derived cells. PMID: 17386109 Ref: Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells. PMID: 17463182 Ref: Whole genome analysis for liver metastasis gene signatures in colorectal cancer. PMID: 17640062 Ref: Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells. PMID: 17671748 |
Ref: WNT5A exhibits tumor-suppressive activity through antagonizing the Wnt/beta-catenin signaling, and is frequently methylated in colorectal cancer. PMID: 18172252 |
Ref: Amino acid limitation induces down-regulation of WNT5a at transcriptional level. PMID: 19063862 Ref: WNT5A gene is aberrantly methylated from the early stages of colorectal cancers. PMID: 19760930 |
Ref: RORalpha attenuates Wnt/beta-catenin signaling by PKCalpha-dependent phosphorylation in colon cancer. PMID: 20122401 Ref: Genistein increases gene expression by demethylation of WNT5a promoter in colon cancer cell line SW1116. PMID: 21115903 |
Ref: DNA methylation predicts recurrence from resected stage III proximal colon cancer. PMID: 21509761 Ref: Promoter methylation of Wnt5a is associated with microsatellite instability and BRAF V600E mutation in two large populations of colorectal cancer patients. PMID: 21587258 Ref: Extracellular Calcium-Sensing Receptor Inhibition of Intestinal EpithelialTNF Signaling Requires CaSR-Mediated Wnt5a/Ror2 Interaction. PMID: 21603229 Ref: A switch from canonical to noncanonical Wnt signaling mediates drug resistance in colon cancer cells. PMID: 22073312 |
Ref: Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions in the colon. PMID: 22363130 Ref: Silencing of Wnt5a during colon cancer metastasis involves histone modifications. PMID: 22522911 Ref: Targeting of Noncanonical Wnt5a Signaling by AP-1 Blocker Dominant-Negative Jun When It Inhibits Skin Carcinogenesis. PMID: 22893789 Ref: Vitamin D intake is negatively associated with promoter methylation of the Wnt antagonist gene DKK1 in a large group of colorectal cancer patients. PMID: 22966878 Ref: [Expression of Wnt5a, APC, beta-catenin and their clinical significance in human colorectal adenocarcinoma]. PMID: 23159080 Ref: Methylation of the WNT5A gene is frequently detected in early gastric carcinoma. PMID: 23178630 |
Ref: Genistein, a soya isoflavone, prevents azoxymethane-induced up-regulation of WNT/beta-catenin signalling and reduces colon pre-neoplasia in rats. PMID: 22716201 Ref: Extracellular calcium-sensing receptor/PTH knockout mice colons have increased Wnt/beta-catenin signaling, reduced non-canonical Wnt signaling, and increased susceptibility to azoxymethane-induced aberrant crypt foci. PMID: 23545937 Ref: DNA methylation and histone modifications of Wnt genes by genistein during colon cancer development. PMID: 23598468 Ref: Inhibitory effect of a standardized pomegranate fruit extract on Wnt signalling in 1, 2-dimethylhydrazine induced rat colon carcinogenesis. PMID: 23722564 Ref: Wnt5a promotes human colon cancer cell migration and invasion but does not augment intestinal tumorigenesis in Apc1638N mice. PMID: 23764752 Ref: The prognostic significance of WNT pathway in surgically-treated colorectal cancer: beta-catenin expression predicts for disease-free survival. PMID: 24123033 Ref: WNT5A encodes two isoforms with distinct functions in cancers. PMID: 24260410 |
Ref: Introducing a novel and robust technique for determining lymph node status in colorectal cancer. PMID: 24169164 Ref: Wnt5a suppresses colon cancer by inhibiting cell proliferation and epithelial-mesenchymal transition. PMID: 24464650 Ref: Screening of hub genes and pathways in colorectal cancer with microarray technology. PMID: 24504536 Ref: Wnt3a expression is associated with MMP-9 expression in primary tumor and metastatic site in recurrent or stage IV colorectal cancer. PMID: 24564183 Ref: Downregulation of WIF-1 and Wnt5a in patients with colorectal carcinoma: clinical significance. PMID: 24833087 Ref: CSNK1E/CTNNB1 are synthetic lethal to TP53 in colorectal cancer and are markers for prognosis. PMID: 24947187 Ref: Promoter methylation analysis of WNT/beta-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer. PMID: 25107489 Ref: A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. PMID: 25417160 |
Ref: Insight into the role of Wnt5a-induced signaling in normal and cancer cells. PMID: 25619716 Ref: Shenling Baizhu San supresses colitis associated colorectal cancer through inhibition of epithelial-mesenchymal transition and myeloid-derived suppressor infiltration. PMID: 25897964 Ref: Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth. PMID: 26018088 Ref: The role of the REG4 gene and its encoding product in ovarian epithelial carcinoma. PMID: 26077911 Ref: Analysis of Wnt and beta-catenin Expression in Advanced Colorectal Cancer. PMID: 26168479 |
Ref: Effect of 1,25-dihydroxyvitamin D3 on the Wnt pathway in non-malignant colonic cells. PMID: 25777538 Ref: Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications. PMID: 26984550 Ref: Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway. PMID: 27139420 Ref: Aberrant DNA methylation of WNT pathway genes in the development and progression of CIMP-negative colorectal cancer. PMID: 27245242 Ref: Non-canonical WNT5A signaling up-regulates the expression of the tumor suppressor 15-PGDH and induces differentiation of colon cancer cells. PMID: 27522468 Ref: Quercetin Confers Tumoricidal Activity Through Multipathway Mechanisms in A N-Methylnitrosourea Rat Model of Colon Cancer PMID: 28032729 |
Ref: Wnt5b-associated exosomes promote cancer cell migration and proliferation. PMID: 27762090 Ref: TrpC5 regulates differentiation through the Ca2+/Wnt5a signalling pathway in colorectal cancer. PMID: 27895148 Ref: Pro-metastatic intracellular signaling of the elaidic trans fatty acid. PMID: 27959384 Ref: WNT5A Promoter Methylation Is Associated with Better Responses and Longer Progression-Free Survival in Colorectal Cancer Patients Treated with 5-Fluorouracil-Based Chemotherapy. PMID: 28051879 Ref: RSPO2 suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt pathway. PMID: 28600110 Ref: EZH2 is involved in silencing of WNT5A during epithelial-mesenchymal transition of colon cancer cell line. PMID: 28748258 Ref: Distinct roles and differential expression levels of Wnt5a mRNA isoforms in colorectal cancer cells. PMID: 28859077 Ref: Inhibition of Wnt/beta-Catenin pathway and Histone acetyltransferase activity by Rimonabant: a therapeutic target for colon cancer. PMID: 28916833 Ref: microRNA-335 inhibits colorectal cancer HCT116 cells growth and epithelial-mesenchymal transition (EMT) process by targeting Twist1. PMID: 29441907 |
Ref: MicroRNA 26b promotes colorectal cancer metastasis by downregulating phosphatase and tensin homolog and wingless-type MMTV integration site family member 5A. PMID: 29160937 Ref: beta-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells. PMID: 29453334 Ref: Delineating the underlying molecular mechanisms and key genes involved in metastasis of colorectal cancer via bioinformatics analysis. PMID: 29517105 Ref: CpG Island Methylator Phenotype and Methylation of Wnt Pathway Genes Together Predict Survival in Patients with Colorectal Cancer. PMID: 29869456 Ref: Wnt/beta-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells. PMID: 30097126 |