Primary Site >> Colorectal Cancer
Gene >> WNT3A
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Ref: Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT14 by IFNgamma and up-regulation of WNT14B by beta-estradiol. PMID: 11713592 |
Ref: Frequent up-regulation of WNT5A mRNA in primary gastric cancer. PMID: 11956659 Ref: Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B in human cancer. PMID: 12239632 |
Ref: The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer. PMID: 15592505 |
Ref: Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation. PMID: 16735606 |
Ref: Regulation of norrin receptor frizzled-4 by Wnt2 in colon-derived cells. PMID: 17386109 |
Ref: Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival. PMID: 18465804 Ref: Low concentrations of resveratrol inhibit Wnt signal throughput in colon-derived cells: implications for colon cancer prevention. PMID: 18504708 Ref: Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells. PMID: 18826597 Ref: Natural derivatives of curcumin attenuate the Wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300. PMID: 19000900 |
Ref: Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model. PMID: 19144919 Ref: The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15. PMID: 19576224 Ref: Isoreserpine promotes beta-catenin degradation via Siah-1 up-regulation in HCT116 colon cancer cells. PMID: 19607803 Ref: Inhibition of GSK-3beta enhances reovirus-induced apoptosis in colon cancer cells. PMID: 19639182 Ref: DICKKOPF-4 and -2 genes are upregulated in human colorectal cancer. PMID: 19659606 Ref: Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant {beta}-Catenin Activation in Colon Cancer. PMID: 20008853 |
Ref: Murrayafoline A attenuates the Wnt/beta-catenin pathway by promoting the degradation of intracellular beta-catenin proteins. PMID: 19962966 Ref: MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway. PMID: 20128690 Ref: FOXQ1 is overexpressed in colorectal cancer and enhances tumorigenicity and tumor growth. PMID: 20145154 Ref: A system-wide investigation of the dynamics of Wnt signaling reveals novel phases of transcriptional regulation. PMID: 20383323 Ref: Positive feedback regulation between phospholipase D and Wnt signaling promotes Wnt-driven anchorage-independent growth of colorectal cancer cells. PMID: 20711340 |
Ref: Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active beta-catenin. PMID: 20856206 Ref: A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/beta-catenin signaling and colon cancer cell tumorigenesis. PMID: 21321609 Ref: A coactivator role of CARM1 in the dysregulation of beta-catenin activity in colorectal cancer cell growth and gene expression. PMID: 21478268 Ref: Extracellular Calcium-Sensing Receptor Inhibition of Intestinal EpithelialTNF Signaling Requires CaSR-Mediated Wnt5a/Ror2 Interaction. PMID: 21603229 Ref: FAK and WNT signaling: the meeting of two pathways in cancer and development. PMID: 21707509 Ref: Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. PMID: 21889923 |
Ref: beta-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells. PMID: 22082586 Ref: Phosphorylation of beta-catenin at serine 663 regulates its transcriptional activity. PMID: 22369945 Ref: Wnt/beta-catenin signaling mediates the antitumor activity of magnolol in colorectal cancer cells. PMID: 22550094 Ref: MENA is a transcriptional target of the Wnt/beta-catenin pathway. PMID: 22615875 Ref: LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. PMID: 22615920 Ref: Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells. PMID: 23144924 |
Ref: Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway. PMID: 22824791 Ref: Cripto-1 enhances the canonical Wnt/beta-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors. PMID: 23022962 Ref: Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells. PMID: 23142137 Ref: The effect of phloretin on human gammadelta T cells killing colon cancer SW-1116 cells. PMID: 23174508 Ref: Invasive colon cancer, but not non-invasive adenomas induce a gradient effect of Wnt pathway receptor frizzled 1 (Fz1) expression in the tumor microenvironment. PMID: 23442549 Ref: Protein kinase C delta negatively modulates canonical Wnt pathway and cell proliferation in colon tumor cell lines. PMID: 23520519 Ref: Extracellular calcium-sensing receptor/PTH knockout mice colons have increased Wnt/beta-catenin signaling, reduced non-canonical Wnt signaling, and increased susceptibility to azoxymethane-induced aberrant crypt foci. PMID: 23545937 Ref: alpha-Catenin interacts with APC to regulate beta-catenin proteolysis and transcriptional repression of Wnt target genes. PMID: 24240237 Ref: Modulation of beta-catenin signaling by the inhibitors of MAP kinase, tyrosine kinase, and PI3-kinase pathways. PMID: 24324366 Ref: Inhibition of Wnt/beta-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells. PMID: 24399733 |
Ref: Tussilagone suppresses colon cancer cell proliferation by promoting the degradation of beta-catenin. PMID: 24269588 Ref: Monensin inhibits canonical Wnt signaling in human colorectal cancer cells and suppresses tumor growth in multiple intestinal neoplasia mice. PMID: 24552772 Ref: Wnt3a expression is associated with MMP-9 expression in primary tumor and metastatic site in recurrent or stage IV colorectal cancer. PMID: 24564183 Ref: Analysis of Wnt signaling beta-catenin spatial dynamics in HEK293T cells. PMID: 24712863 Ref: Thymine DNA glycosylase promotes transactivation of beta-catenin/TCFs by cooperating with CBP. PMID: 24748645 Ref: DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/beta-catenin signaling pathway genes. PMID: 24811787 Ref: LGR5 regulates survival through mitochondria-mediated apoptosis and by targeting the Wnt/beta-catenin signaling pathway in colorectal cancer cells. PMID: 25025569 Ref: Wnt/beta-catenin signaling induces the transcription of cystathionine-gamma-lyase, a stimulator of tumor in colon cancer. PMID: 25193114 Ref: Green tea polyphenol EGCG suppresses Wnt/beta-catenin signaling by promoting GSK-3beta- and PP2A-independent beta-catenin phosphorylation/degradation. PMID: 25352148 Ref: Wnt3a expression is associated with epithelial-mesenchymal transition and promotes colon cancer progression. PMID: 25499541 |
Ref: Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by beta-catenin activity. PMID: 25109331 Ref: Myc-interacting zinc-finger protein 1 positively regulates Wnt signalling by protecting Dishevelled from Dapper1-mediated degradation. PMID: 25558878 Ref: Atractylochromene Is a Repressor of Wnt/beta-Catenin Signaling in Colon Cancer Cells. PMID: 25593640 Ref: Wnt3a Promotes the Vasculogenic Mimicry Formation of Colon Cancer via Wnt/beta-Catenin Signaling. PMID: 26266404 Ref: Positive feedback loop of hepatoma-derived growth factor and beta-catenin promotes carcinogenesis of colorectal cancer. PMID: 26296979 |
Ref: Distinct epigenetic signatures elucidate enhancer-gene relationships that delineate CIMP and non-CIMP colorectal cancers. PMID: 27049830 Ref: Cytotoxic activity of aeroplysinin-1 against colon cancer cells by promoting beta-catenin degradation. PMID: 27120392 Ref: The chromatin-remodeling enzyme BRG1 promotes colon cancer progression via positive regulation of WNT3A. PMID: 27852072 |
Ref: Dishevelled stability is positively regulated by PKCzeta-mediated phosphorylation induced by Wnt agonists. PMID: 28366812 Ref: Gene expression profiling demonstrates WNT/beta-catenin pathway genes alteration in Mexican patients with colorectal cancer and diabetes mellitus. PMID: 29135090 Ref: microRNA-335 inhibits colorectal cancer HCT116 cells growth and epithelial-mesenchymal transition (EMT) process by targeting Twist1. PMID: 29441907 |
Ref: Introduction of hsa-miR-103a and hsa-miR-1827 and hsa-miR-137 as new regulators of Wnt signaling pathway and their relation to colorectal carcinoma. PMID: 28817181 Ref: The human PKP2/plakophilin-2 gene is induced by Wnt/beta-catenin in normal and colon cancer-associated fibroblasts. PMID: 29044515 Ref: Beta-elemene increases chemosensitivity to 5-fluorouracil through down-regulating microRNA-191 expression in colorectal carcinoma cells. PMID: 29737579 Ref: SMAR1 inhibits Wnt/beta-catenin signaling and prevents colorectal cancer progression. PMID: 29765542 Ref: YAP-dependent ubiquitination and degradation of beta-catenin mediates inhibition of Wnt signalling induced by Physalin F in colorectal cancer. PMID: 29789528 Ref: MiR-195 suppresses colon cancer proliferation and metastasis by targeting WNT3A. PMID: 29948330 Ref: Wnt3a/beta-Catenin Signaling Conditions Differentiation of Partially Exhausted T-effector Cells in Human Cancers. PMID: 30018041 Ref: miR-155 Is Downregulated in Familial Adenomatous Polyposis and Modulates WNT Signaling by Targeting AXIN1 and TCF4. PMID: 30072583 Ref: Tannins from Syzygium guineense suppress Wnt signaling and proliferation of Wnt-dependent tumors through a direct effect on secreted Wnts. PMID: 30098400 |