Primary Site >> Colorectal Cancer
Gene >> VEGFA
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Ref: Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract. PMID: 8402650 |
Ref: Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. PMID: 7535799 Ref: Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. PMID: 7553632 Ref: Platelet-derived growth factor-B increases colon cancer cell growth in vivo by a paracrine effect. PMID: 7593201 Ref: Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. PMID: 7664263 |
Ref: Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancer. PMID: 8690519 Ref: Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by cell density. PMID: 8752153 Ref: Platelet-derived endothelial cell growth factor in human colon cancer angiogenesis: role of infiltrating cells. PMID: 8757194 Ref: Down-regulation of vascular endothelial growth factor in human colon carcinoma cell lines by antisense transfection decreases endothelial cell proliferation. PMID: 8909524 Ref: Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma. PMID: 8910616 Ref: Serum basic fibroblast growth factor and vascular endothelial growth factor and tumour growth kinetics in advanced colorectal cancer. PMID: 8922199 Ref: Quantitative analysis of vascular endothelial growth factor expression in chronic lymphocytic leukaemia. PMID: 21544327 Ref: Microvessel density and vascular endothelial growth factor expression in human tumors of different localization. PMID: 21594393 |
Ref: Vessel counts and expression of vascular endothelial growth factor as prognostic factors in node-negative colon cancer. PMID: 9161399 Ref: Effect of host microenvironment on the microcirculation of human colon adenocarcinoma. PMID: 9284816 Ref: Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by activity of src kinase. PMID: 9288158 Ref: Combined analysis of p53 and vascular endothelial growth factor expression in colorectal carcinoma for determination of tumor vascularity and liver metastasis. PMID: 9355971 Ref: Association of vascular endothelial growth factor expression with tumor angiogenesis, survival and thymidine phosphorylase/platelet-derived endothelial cell growth factor expression in human colorectal cancer. PMID: 9570376 Ref: Characterization and purification of angiogenic factor derived from highly liver metastatic colon cancer cells. PMID: 21528301 Ref: Vascular endothelial growth factor expression correlates with hematogenous metastasis and prognosis in colorectal carcinoma. PMID: 21590063 |
Ref: Molecular changes during the genesis of human gliomas. PMID: 9407626 Ref: Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-src. PMID: 9422768 Ref: Circulating vascular endothelial growth factor in patients with colorectal cancer. PMID: 9468253 Ref: p53, vessel count, and vascular endothelial growth factor expression in human colon cancer. PMID: 9495355 Ref: Significance of platelet-derived endothelial cell growth factor in the angiogenesis of human gastric cancer. PMID: 9516932 Ref: Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells. PMID: 9520413 Ref: Vascular endothelial growth factor (VEGF) mRNA isoform expression pattern is correlated with liver metastasis and poor prognosis in colon cancer. PMID: 9528847 Ref: Regional suppression of tumor growth by in vivo transfer of a cDNA encoding a secreted form of the extracellular domain of the flt-1 vascular endothelial growth factor receptor. PMID: 9581905 Ref: Involvement of vascular endothelial growth factor and urokinase-type plasminogen activator receptor in microvessel invasion in human colorectal cancers. PMID: 9583734 Ref: Preoperative serum vascular endothelial growth factor can predict stage in colorectal cancer. PMID: 9607588 Ref: Vascular endothelial growth factor expression is reduced in liver metastasis from colorectal cancer and correlates with urokinase-type plasminogen activator. PMID: 9615749 Ref: Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer. PMID: 9622060 Ref: [Significance of p53 and VEGF expression in liver metastasis from colorectal cancer]. PMID: 9703827 Ref: Quantitative analysis of vascular endothelial growth factor in colon cancer. Clinical and experimental. PMID: 9704754 Ref: Anti-tumor and anti-metastatic effects of human-vascular-endothelial-growth-factor-neutralizing antibody on human colon and gastric carcinoma xenotransplanted orthotopically into nude mice. PMID: 9714067 Ref: Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. PMID: 9731515 Ref: Regulation of vascular endothelial growth factor receptor KDR in vitro by a soluble factor in confluent endothelial cells. PMID: 9732240 Ref: [Implication of VEGF and MMPs in hepatic metastasis of human colon cancer]. PMID: 9742524 Ref: [Therapeutic effect of angiogenesis inhibitors on liver metastases of human colorectal carcinoma]. PMID: 9742525 Ref: Quantitative analysis of basic fibroblast growth factor and vascular endothelial growth factor in human colorectal cancer. PMID: 9743297 Ref: Tissue-specific expression pattern of vascular endothelial growth factor isoforms in the malignant transformation of lung and colon. PMID: 9744306 Ref: Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer. PMID: 9823983 Ref: Significance of angiogenic factors in liver metastatic tumors originating from colorectal cancers. PMID: 9881494 Ref: Angiogenesis in normal tissue adjacent to colon cancer. PMID: 9881940 Ref: Clinical significance of plasma vascular endothelial growth factor in gastrointestinal cancer. PMID: 10070308 Ref: [Determination of vascular endothelial growth factor (VEGF) concentration in serum of patients with colorectal carcinoma]. PMID: 14518267 |
Ref: Thrombospondin 2 expression is correlated with inhibition of angiogenesis and metastasis of colon cancer. PMID: 9888480 Ref: Increased expression of angiogenic factors in human colonic angiodysplasia. PMID: 10201485 Ref: Inhibition of liver metastasis of colon cancer by in vivo administration of anti-vascular endothelial growth factor antibody. PMID: 10203590 Ref: A novel gene delivery system targeting cells expressing VEGF receptors. PMID: 10321685 Ref: Markedly elevated levels of vascular endothelial growth factor in malignant ascites. PMID: 10379858 Ref: Regulation of vascular endothelial growth factor expression in human colon cancer by interleukin-1beta. PMID: 10408390 Ref: Protein markers in colorectal cancer: predictors of liver metastasis. PMID: 10450731 Ref: Implication of vascular endothelial growth factor in the development and metastasis of human cancers. PMID: 10457902 Ref: PECAM-1 (CD31) functions as a reservoir for and a modulator of tyrosine-phosphorylated beta-catenin. PMID: 10462517 Ref: Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. PMID: 10463618 Ref: Extracellular signal-regulated kinase activation is required for up-regulation of vascular endothelial growth factor by serum starvation in human colon carcinoma cells. PMID: 10519388 Ref: Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis. PMID: 10554007 Ref: Vascular endothelial growth factor overproduced by tumour cells acts predominantly as a potent angiogenic factor contributing to malignant progression. PMID: 10607018 Ref: Effect of novel CAAX peptidomimetic farnesyltransferase inhibitor on angiogenesis in vitro and in vivo. PMID: 10658533 Ref: [An angiogenesis study of Dukes' B colonic tumors]. PMID: 10687262 Ref: [Microvessel quantitation and expression of VEGF in colorectal tumors]. PMID: 11776618 Ref: [Liver metastasis in colorectal cancer and tumor angiogenesis]. PMID: 11829853 Ref: p27(kipl) protein expression: an independent prognostic factor in rectal carcinoma stages I-III. PMID: 23574593 |
Ref: Tissue factor expression in human colorectal carcinoma: correlation with hepatic metastasis and impact on prognosis. PMID: 10640960 Ref: Clinical significance of serum vascular endothelial growth factor in colorectal cancer patients: correlation with clinicopathological factors and tumor markers. PMID: 10671682 Ref: Enhancement of angiogenesis, tumor growth, and metastasis by transfection of vascular endothelial growth factor into LoVo human colon cancer cell line. PMID: 10690548 Ref: Preoperative treatment with tegafur suppositories enhances apoptosis and reduces the intratumoral microvessel density of human colorectal carcinoma. PMID: 10699888 Ref: Expression of vascular endothelial growth factor and thrombospondin-1 in colorectal carcinoma. PMID: 10719053 Ref: Plasma vascular endothelial but not fibroblast growth factor levels correlate with colorectal liver mestastasis vascularity and volume. PMID: 10737380 Ref: Vegf, Vegf-B, Vegf-C and their receptors KDR, FLT-1 and FLT-4 during the neoplastic progression of human colonic mucosa. PMID: 10738243 Ref: Prognostic role of thymidylate synthase, thymidine phosphorylase/platelet-derived endothelial cell growth factor, and proliferation markers in colorectal cancer. PMID: 10741735 Ref: Implication of vascular endothelial growth factor and p53 status for angiogenesis in noninvasive colorectal carcinoma. PMID: 10760758 Ref: Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients. PMID: 10762747 Ref: Factors influencing tissue concentration of vascular endothelial growth factor in colorectal carcinoma. PMID: 10763960 Ref: Arginine-rich anti-vascular endothelial growth factor peptides inhibit tumor growth and metastasis by blocking angiogenesis. PMID: 10788475 Ref: Expression of CD44, vascular endothelial growth factor, and proliferating cell nuclear antigen in severe venous invasional colorectal cancer and its relationship to liver metastasis. PMID: 10795863 Ref: Vascular endothelial growth factor in human colon cancer: biology and therapeutic implications. PMID: 10804085 Ref: Host cyclooxygenase-2 modulates carcinoma growth. PMID: 10841517 Ref: Expression of vascular endothelial growth factor can predict event-free survival in stage II colon cancer. PMID: 10914727 Ref: Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases. PMID: 10931447 Ref: Ribozyme-mediated inactivation of mutant K-ras oncogene in a colon cancer cell line. PMID: 10952790 Ref: Correlation of plasma and serum vascular endothelial growth factor levels with platelet count in colorectal cancer: clinical evidence of platelet scavenging? PMID: 10955796 Ref: Effect of prostaglandin E1 on vascular endothelial growth factor production by human macrophages and colon cancer cells. PMID: 10965822 Ref: Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis. PMID: 10987313 Ref: Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells. PMID: 10999768 Ref: Pre-operative serum vascular endothelial growth factor can select patients for adjuvant treatment after curative resection in colorectal cancer. PMID: 11076648 Ref: Soluble vascular endothelial growth factor levels in patients with primary colorectal carcinoma. The Danish RANX05 Colorectal Cancer Study Group. PMID: 11078612 Ref: [Continuous hepatic arterial infusion of 5-fluorouracil with leucovorin for unresectable liver metastases from colorectal cancer]. PMID: 11086440 Ref: The role of angiogenesis in the accumulation of peritoneal fluid in benign conditions and the development of malignant ascites in the female. PMID: 11093042 Ref: UFT and its metabolites inhibit cancer-induced angiogenesis. Via a VEGF-related pathway. PMID: 11098498 Ref: Relationship between plasma levels of vascular endothelial growth factor and serum levels of interleukin-12 in patients with colorectal cancer. PMID: 11131678 Ref: Plasminogen activator system, vascular endothelial growth factor, and colorectal cancer progression. PMID: 11193049 Ref: Social isolation stress augments angiogenesis induced by colon 26-L5 carcinoma cells in mice. PMID: 11206831 Ref: Differences of vascular endothelial growth factor (VEGF) expression between liver and abdominal metastases from colon cancer. Implications for the treatment with VEGF inhibitors. PMID: 11827068 Ref: Rectal cancer recurrence: factors and mechanisms. PMID: 23578036 |
Ref: CD55 is over-expressed in the tumour environment. PMID: 11139317 Ref: Effects of an antibody to vascular endothelial growth factor receptor-2 on survival, tumor vascularity, and apoptosis in a murine model of colon carcinomatosis. PMID: 11172585 Ref: Gene expression analysis in colorectal cancer using practical DNA array filter. PMID: 11227951 Ref: Vascular endothelial growth factor (VEGF)--a valuable serum tumour marker in patients with colorectal cancer? PMID: 11237490 Ref: EGCG, a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells. PMID: 11259102 Ref: Inhibition of vascular endothelial growth factor by octreotide in colorectal cancer patients. PMID: 11291560 Ref: Upregulated expression of angiogenesis genes and down regulation of cell cycle genes in human colorectal cancer tissue determined by cDNA macroarray. PMID: 11299727 Ref: Vascular endothelial growth factor expression, S-phase fraction and thymidylate synthase quantitation in node-positive colon cancer: relationships with tumor recurrence and resistance to adjuvant chemotherapy. PMID: 11300331 Ref: A strategy for antitumor vascular therapy by targeting the vascular endothelial growth factor: receptor complex. PMID: 11325835 Ref: 3D microvascular architecture of pre-cancerous lesions and invasive carcinomas of the colon. PMID: 11355947 Ref: Urokinase receptor and vascular endothelial growth factor are synergistically associated with the liver metastasis of colorectal cancer. PMID: 11376560 Ref: [Significance of angiogenesis and clinical application of anti-angiogenesis]. PMID: 11394000 Ref: Bacteria-induced release of white cell--and platelet-derived vascular endothelial growth factor in vitro. PMID: 11449957 Ref: Vascular endothelial growth factor (VEGF) expression regulates angiogenesis accompanying tumor growth in a peritoneal disseminated tumor model. PMID: 11491018 Ref: Human colon cancer produces a factor which induces the proliferation of venous endothelial cells. PMID: 11496316 Ref: Abnormally enhanced blood concentrations of vascular endothelial growth factor (VEGF) in metastatic cancer patients and their relation to circulating dendritic cells, IL-12 and endothelin-1. PMID: 11501971 Ref: Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors. PMID: 11506500 Ref: Transcriptional response to hypoxia in human tumors. PMID: 11535709 Ref: A prospective analysis of plasma endostatin levels in colorectal cancer patients with liver metastases. PMID: 11597016 Ref: Over-expression of vascular endothelial growth factor after preoperative radiation therapy for rectal cancer. PMID: 11605042 Ref: Concurrent expression of angiogenic growth factors and neovascularization during tumourigenesis in colorectal carcinoma patients. PMID: 11669335 Ref: VEGF-A, VEGF-C, and VEGF-D in colorectal cancer progression. PMID: 11687953 Ref: Review: molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis. PMID: 11688844 Ref: The role of HER2 in angiogenesis. PMID: 11706393 Ref: [Significance of vascular endothelial growth factor expression in colorectal cancer]. PMID: 11718049 Ref: Expression of vascular endothelial growth factor and its receptor KDR (kinase domain-containing receptor)/Flk-1 (fetal liver kinase-1) as prognostic factors in human colorectal cancer. PMID: 11723743 Ref: VEGF antagonists. PMID: 11727506 Ref: Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer. PMID: 11729113 Ref: Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells. PMID: 11733561 Ref: Non-invasive methods of assessing angiogenesis and their value in predicting response to treatment in colorectal cancer. PMID: 11736977 Ref: Morphologic analysis of microvessels in colorectal tumors with respect to the formation of liver metastases. PMID: 11745821 Ref: Interleukin-15 expression is associated with malignant potential in colon cancer cells. PMID: 11752902 Ref: Vascular endothelial growth factor is upregulated by interleukin-1 beta in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway. PMID: 11806247 Ref: Prognostic role of angiogenesis in colorectal cancer. PMID: 11908690 |
Ref: Elevated IL-8 levels in the drainage vein of resectable Dukes' C colorectal cancer indicate high risk for developing hepatic metastasis. PMID: 11748475 Ref: Upregulation of vascular endothelial growth factor by hydrogen peroxide in human colon cancer. PMID: 11833093 Ref: Relevance of biologic markers in colorectal carcinoma: a comparative study of a broad panel. PMID: 11857296 Ref: Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. PMID: 11861378 Ref: Prognostic impact of matched preoperative plasma and serum VEGF in patients with primary colorectal carcinoma. PMID: 11875709 Ref: Expression of tissue factor and vascular endothelial growth factor is associated with angiogenesis in colorectal cancer. PMID: 11921018 Ref: [Upregulation of vascular endothelial growth factor by peroxide in human colon cancer]. PMID: 11953178 Ref: Neoangiogenesis in colon cancer: correlation between vascular density, vascular endothelial growth factor (VEGF) and p53 protein expression. PMID: 11956638 Ref: Enhanced expression of vascular endothelial growth factor (VEGF) plays a critical role in the tumor progression potential induced by simian virus 40 large T antigen. PMID: 11973650 Ref: Systemic treatment of colorectal cancer. PMID: 11978525 Ref: Effects of IL-2 preoperative immunotherapy on surgery-induced changes in angiogenic regulation and its prevention of VEGF increase and IL-12 decline. PMID: 11995457 Ref: Microvessel morphology and vascular endothelial growth factor expression in human colonic carcinoma with or without metastasis. PMID: 12003996 Ref: Modulation of angiogenesis-related proteins synthesis by sodium butyrate in colon cancer cell line HT29. PMID: 12016145 Ref: Clinical significance of preoperative serum vascular endothelial growth factor levels in patients with colorectal cancer and the effect of tumor surgery. PMID: 12019409 Ref: TGF beta1 expression and angiogenesis in colorectal cancer tissue. PMID: 12046078 Ref: A critical role for ras-mediated, epidermal growth factor receptor-dependent angiogenesis in mouse skin carcinogenesis. PMID: 12067982 Ref: Association of p53 mutations, microvessel density and neoangiogenesis in pairs of colorectal cancers and corresponding liver metastases. PMID: 12118317 Ref: Inhibitory effect of a selective cyclooxygenase-2 inhibitor on liver metastasis of colon cancer. PMID: 12124799 Ref: [Expression of vascular endothelial growth factor in colorectal cancer and its clinical significance]. PMID: 12133521 Ref: In vivo release of vascular endothelial growth factor from colorectal carcinomas. PMID: 12138238 Ref: Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. PMID: 12149254 Ref: Expression of interleukin-8, heme oxygenase-1 and vascular endothelial growth factor in DLD-1 colon carcinoma cells exposed to pyrrolidine dithiocarbamate. PMID: 12151344 Ref: Soluble FLT-1 is detectable in the sera of colorectal and breast cancer patients. PMID: 12168886 Ref: Hypoxia upregulates Bcl-2 expression and suppresses interferon-gamma induced antiangiogenic activity in human tumor derived endothelial cells. PMID: 12173346 Ref: Expression of vascular endothelial growth factor, mitogen-activated protein kinase and p53 in human colorectal cancer. PMID: 12174901 Ref: Prognostic value of plasma vascular endothelial growth factor in patients with colorectal cancer. PMID: 12174940 Ref: Tumour markers as early predictors of response to chemotherapy in advanced colorectal carcinoma. PMID: 12196369 Ref: Targeting vascular endothelial growth factor in colorectal cancer. PMID: 12199627 Ref: The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis. PMID: 12208766 Ref: VEGF isoforms and mutations in human colorectal cancer. PMID: 12209585 Ref: Antiangiogenic effect of octreotide inhibits the growth of human rectal neuroendocrine carcinoma. PMID: 12239460 Ref: Systemic interleukin-6 responses following administration of adenovirus gene transfer vectors to humans by different routes. PMID: 12349828 Ref: Blockade of insulin-like growth factor I receptor function inhibits growth and angiogenesis of colon cancer. PMID: 12374697 Ref: Impact of insulin-like growth factor receptor-I function on angiogenesis, growth, and metastasis of colon cancer. PMID: 12379772 Ref: Determination of vascular endothelial growth factor (VEGF) in circulating blood: significance of VEGF in various leucocytes and platelets. PMID: 12387579 Ref: Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer. PMID: 12405290 Ref: Unique properties of 189 amino acid isoform of vascular endothelial growth factor in tumorigenesis. PMID: 12429975 Ref: [Anti-angiogenic drugs probable complement in cancer therapy]. PMID: 12448292 Ref: Arterio-venous gradients of IL-6, plasma and serum VEGF and D-dimers in human cancer. PMID: 12454774 Ref: [Inhibitory effects of TNP-470 in combination with 5-fluorouracil on growth of human colon cancer]. PMID: 12520739 Ref: VEGF concentrations in tumour arteries and veins from patients with rectal cancer. PMID: 12529018 Ref: Correlation of plasma level and immunohistochemical expression of vascular endothelial growth factor in patients with advanced colorectal cancer. PMID: 12530025 Ref: Prognostic role of serum vascular endothelial growth factor, basic fibroblast growth factor and nitric oxide in patients with colorectal carcinoma. PMID: 12543084 Ref: Kinetics of postoperative serum vascular endothelial growth factor (VEGF)--can it be used to predict curative resections in colorectal cancer? PMID: 12552982 Ref: Plasma basic fibroblast growth factor levels in colorectal cancer: a clinically useful assay? PMID: 12553380 Ref: A role of histone H4 hypoacetylation in vascular endothelial growth factor expression in colon mucosa adjacent to implanted cancer in athymic mice cecum. PMID: 12865631 Ref: Tumour's angiogenesis--the function of VEGF and bFGF in colorectal cancer. PMID: 12898895 |
Ref: Clinical significance of angiogenic factor expression at the deepest invasive site of advanced colorectal carcinoma. PMID: 12457033 Ref: The angiogenic switch of human colon cancer occurs simultaneous to initiation of invasion. PMID: 12469136 Ref: Isolation and characterisation of vascular endothelial growth factor-165 specific scFv fragments by phage display. PMID: 12527931 Ref: Immunodetection and molecular forms of plasma vascular endothelial growth factor-C. PMID: 12527932 Ref: Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. PMID: 12538661 Ref: Butyrate impairs intestinal tumor cell-induced angiogenesis by inhibiting HIF-1alpha nuclear translocation. PMID: 12559948 Ref: Vascular endothelial growth factor, CD68, and epidermal growth factor receptor expression and survival in patients with Stage II and Stage III colon carcinoma: a role for the host response in prognosis. PMID: 12569594 Ref: Inhibition of colon tumor progression and angiogenesis by the Ink4a/Arf locus. PMID: 12591718 Ref: Inducible nitric oxide synthase expression in human colorectal cancer: correlation with tumor angiogenesis. PMID: 12598314 Ref: Expression profiling of blood samples from an SU5416 Phase III metastatic colorectal cancer clinical trial: a novel strategy for biomarker identification. PMID: 12657164 Ref: The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation. PMID: 12657718 Ref: Expression of platelet-derived endothelial cell growth factor in inflammatory bowel disease. PMID: 12673445 Ref: Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma. PMID: 12673675 Ref: The potential for a selective cyclooxygenase-2 inhibitor in the prevention of liver metastasis in human colorectal cancer. PMID: 12680220 Ref: c-MET expression level in primary colon cancer: a predictor of tumor invasion and lymph node metastases. PMID: 12684423 Ref: Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase. PMID: 12684431 Ref: Combination of a selective cyclooxygenase-2 inhibitor with epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 and protein kinase A antisense causes cooperative antitumor and antiangiogenic effect. PMID: 12684433 Ref: Circulating angiogenic growth factor levels in mice bearing human tumors using Luminex Multiplex technology. PMID: 12721760 Ref: Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. PMID: 12727858 Ref: Ets-1 expression in vascular endothelial cells as an angiogenic and prognostic factor in colorectal carcinoma. PMID: 12731728 Ref: Cyclooxygenase-2 expression and angiogenesis in gastric hyperplastic polyp--association with polyp size. PMID: 12743436 Ref: Piroxicam-induced regression of intestinal adenomatous polyps in APC(delta474) mice. PMID: 12746190 Ref: The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression. PMID: 12754739 Ref: Expression of vascular endothelial growth factor D is associated with lymph node metastasis in human colorectal carcinoma. PMID: 12759540 Ref: [Study of angiogenesis in human colorectal carcinoma and its modulation by p53 and K-ras gene]. PMID: 12783699 Ref: Lymphagenesis correlates with expression of vascular endothelial growth factor-C in colorectal cancer. PMID: 12792749 Ref: Clinical significance of vascular endothelial growth factor expression and neovascularization in colorectal carcinoma. PMID: 12800229 Ref: Cyclooxygenase-2 expression and angiogenesis in colorectal cancer. PMID: 12800231 Ref: beta-Catenin regulates vascular endothelial growth factor expression in colon cancer. PMID: 12810642 Ref: Soluble markers for the detection of hypoxia under antiangiogenic treatment. PMID: 12820365 Ref: Changes in circulating VEGF levels in relation to clinical response during chemotherapy for metastatic cancer. PMID: 12841685 Ref: Effects of carbon dioxide and nitrogen on adhesive growth and expressions of E-cadherin and VEGF of human colon cancer cell CCL-228. PMID: 12854171 Ref: Minimally invasive surgery may result in lower peak levels of circulating vascular endothelial growth factor. PMID: 12856846 Ref: p73 Overexpression and angiogenesis in human colorectal carcinoma. PMID: 12865464 Ref: Expression analysis of vascular endothelial growth factors and their relationships to lymph node metastasis in human colorectal cancer. PMID: 12866573 Ref: Vascular endothelial growth factor and soluble Tie-2 receptor in colorectal cancer: associations with disease recurrence. PMID: 12875855 Ref: Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy. PMID: 12888807 Ref: [Expression of tissue factor and vascular endothelial growth factor in colorectal carcinoma]. PMID: 12903530 Ref: Clinical significance of thrombospondin-1 expression in relation to vascular endothelial growth factor and interleukin-10 expression at the deepest invasive tumor site of advanced colorectal carcinoma. PMID: 12963968 Ref: Induction of macrophage migration inhibitory factor by lysophosphatidic acid: relevance to tumor growth and angiogenesis. PMID: 12964047 Ref: Inhibition of angiogenesis by NSAIDs: molecular mechanisms and clinical implications. PMID: 13679997 Ref: Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer and liv PMID: 14517187 Ref: Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids. PMID: 14521839 Ref: CEP-7055: a novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical models. PMID: 14522925 Ref: COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo. PMID: 14563940 Ref: [Treatment of metastatic liver carcinoma: chemotherapy and immunotherapy]. PMID: 14579760 Ref: Effects of major liver resection, with or without recombinant bactericidal/permeability-increasing protein (rBPI21), on the angiogenic profile of patients with metastatic colorectal carcinoma. PMID: 14598357 Ref: Role of VEGF and CD44v6 in differentiating benign from malignant ascites. PMID: 14606105 Ref: [Relationship of hypoxia-inducible factor 1 alpha (HIF-1alpha) gene expression with vascular endothelial growth factor (VEGF) and microvessel density (MVD) in human colorectal adenoma and adenocarcinoma]. PMID: 14613646 Ref: Increased serum transforming growth factor-beta1 in human colorectal cancer correlates with reduced circulating dendritic cells and increased colonic Langerhans cell infiltration. PMID: 14616787 Ref: [Relationship between effectiveness of hepatic artery injection chemotherapy and serum VEGF]. PMID: 14619483 Ref: Roxatidine- and cimetidine-induced angiogenesis inhibition suppresses growth of colon cancer implants in syngeneic mice. PMID: 14646250 Ref: Relationship between expression of CD105 and growth factors in malignant tumors of gastrointestinal tract and its significance. PMID: 14669355 Ref: [Palliative therapy of colorectal cancer]. PMID: 14716142 Ref: [Novel molecular approaches in the therapy of advanced colorectal carcinoma]. PMID: 14716146 Ref: Circulating vascular endothelial growth factor six months after primary surgery as a prognostic marker in patients with colorectal cancer. PMID: 14968945 Ref: Strategies to investigate circulating endothelial cells in cancer. PMID: 15692268 Ref: New oxaliplatin-based combinations in the treatment of colorectal cancer. PMID: 23573555 |
Ref: Increased expression of nuclear factor-kappaB/RelA is correlated with tumor angiogenesis in human colorectal cancer. PMID: 12827408 Ref: LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing mice. PMID: 14593497 Ref: The effects of surgery, with or without rhGM-CSF, on the angiogenic profile of patients treated for colorectal carcinoma. PMID: 14693162 Ref: Elevated perioperative serum vascular endothelial growth factor levels in patients with colon carcinoma. PMID: 14716760 Ref: Expression of VEGF-C and VEGF-D at the invasive edge correlates with lymph node metastasis and prognosis of patients with colorectal carcinoma. PMID: 14720324 Ref: Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. PMID: 14745444 Ref: Resistance to anti-VEGF agents. PMID: 14754405 Ref: Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy. PMID: 14760102 Ref: Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma. PMID: 14767538 Ref: Hepatic expression of ANG2 RNA in metastatic colorectal cancer. PMID: 14768007 Ref: [Colon cancer: what is new in 2004?]. PMID: 14975808 Ref: Antiangiogenic drugs and current strategies for the treatment of lung cancer. PMID: 14981581 Ref: Improved survival of mice bearing liver metastases of colon cancer cells treated with a combination of radioimmunotherapy and antiangiogenic therapy. PMID: 14991242 Ref: Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. PMID: 14996738 Ref: Vascular endothelial growth factor in colorectal cancer. PMID: 14999511 Ref: Increased local vascular endothelial growth factor expression associated with antitumor activity of proteasome inhibitor. PMID: 15004516 Ref: [Serum vascular endothelial growth factor levels in patients with colorectal cancer and its prognostic significance]. PMID: 15012886 Ref: Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis. PMID: 15023347 Ref: The role of new agents in the treatment of colorectal cancer. PMID: 15031593 Ref: Modulation of angiogenesis-related protein synthesis by valproic acid. PMID: 15033455 Ref: Nitric oxide differentially regulates pro- and anti-angiogenic markers in DLD-1 colon carcinoma cells. PMID: 15063730 Ref: Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer. PMID: 15102673 Ref: Correlation of p53 and bcl-2 expression with vascular endothelial growth factor (VEGF), microvessel density (MVD) and clinico-pathological features in colon cancer. PMID: 15142682 Ref: Determination of molecular marker expression can predict clinical outcome in colon carcinomas. PMID: 15161706 Ref: [Chemotherapy]. PMID: 15170977 Ref: Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. PMID: 15172975 Ref: Tumour seeding in peritoneal wound sites in relation to growth-factor expression in early granulation tissue. PMID: 15177504 Ref: Bevacizumab: an angiogenesis inhibitor with efficacy in colorectal and other malignancies. PMID: 15187215 Ref: Systemic treatment of advanced colorectal carcinoma. PMID: 15195891 Ref: Regulation of vascular endothelial growth factor (VEGF)-C and VEGF-D expression by the organ microenvironment in human colon carcinoma. PMID: 15196547 Ref: Expression of vascular endothelial growth factor and receptor flk-1 in colon cancer liver metastases. PMID: 15235888 Ref: [New therapy options in colorectal carcinoma]. PMID: 15253162 Ref: NF-kappaB, macrophage migration inhibitory factor and cyclooxygenase-inhibitions as likely mechanisms behind the acetaminophen- and NSAID-prevention of the ovarian cancer. PMID: 15254653 Ref: Correlation of vascular endothelial growth factor (VEGF) and CEA with clinicopathological variables in colorectal cancer patients. PMID: 15254661 Ref: [Expression and pathobiological implication of hypoxia-inducible factor-1alpha in human colorectal carcinoma]. PMID: 15256117 Ref: COX-2 expression and tumor angiogenesis in colorectal cancer. PMID: 15285012 Ref: Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-g PMID: 15289320 Ref: Integration of novel agents in the treatment of colorectal cancer. PMID: 15309512 Ref: NS-398 inhibits tumor growth and liver metastasis of colon cancer through induction of apoptosis and suppression of the plasminogen activation system in a mouse model. PMID: 15325613 Ref: The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer. PMID: 15328199 Ref: Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications. 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PMID: 26131080 Ref: Expression and clinical significance of vascular endothelial growth factor and fms-related tyrosine kinase 1 in colorectal cancer. PMID: 26137082 Ref: A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy for Colorectal Cancer. PMID: 26137537 Ref: Antiangiogenic Therapy Impedes Infiltration by CD4+ and CD8+ Cells Into an Early Colon Tumor. PMID: 26151046 Ref: eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer. PMID: 26204490 Ref: Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Interleukin-6 and Vascular Endothelial Growth Factor A in Colon Cancer Cells and Induce Angiogenesis. PMID: 26209639 Ref: HIF-1alpha in colorectal carcinoma: review of the literature. PMID: 26214618 Ref: [Impact of preoperative drug therapy on adhesion molecule expression in colorectal cancer liver metastases]. PMID: 26226776 Ref: [Anti-angiogenic treatments in metastatic colorectal cancer: Does a continuous angiogenic blockade make sense?]. PMID: 26232849 Ref: Chemoprevention of Azoxymethane-induced Colonic Carcinogenesis in Balb/c mice Using a Modified Pectin Alginate Probiotic. PMID: 26254367 Ref: Cabozantinib, a Novel c-Met Inhibitor, Inhibits Colorectal Cancer Development in a Xenograft Model. PMID: 26255947 Ref: Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array. PMID: 26258407 Ref: eNOS polymorphisms as predictors of efficacy of bevacizumab-based chemotherapy in metastatic colorectal cancer: data from a randomized clinical trial. PMID: 26259598 Ref: Circulating levels of anti-angiogenic VEGF-A isoform (VEGF-Axxxb) in colorectal cancer patients predicts tumour VEGF-A ratios. PMID: 26269767 Ref: Nef-M1, a peptide antagonist of CXCR4, inhibits tumor angiogenesis and epithelialtomesenchymal transition in colon and breast cancers. PMID: 26318034 Ref: The prognosis was poorer in colorectal cancers that expressed both VEGF and PROK1 (No correlation coefficient between VEGF and PROK1). PMID: 26318037 Ref: Predictive Significance of VEGF and HIF-1alpha Expression in Patients with Metastatic Colorectal Cancer Receiving Chemotherapy Combinations with Bevacizumab. PMID: 26320510 Ref: Correlation study of Bcl-2, B7-H1, EGFR, VEGF and colorectal cancer. PMID: 26328258 Ref: Anti-angiogenic and anti-proliferative effects of inhibition of HIF-1alpha by p-HIF-1alpha RNAi in colorectal cancer. PMID: 26339356 Ref: Changes in expression levels of ERCC1, DPYD, and VEGFA mRNA after first-line chemotherapy of metastatic colorectal cancer: results of a multicenter study. PMID: 26372896 Ref: Dexamethasone inhibits hypoxia-induced epithelial-mesenchymal transition in colon cancer. PMID: 26379394 Ref: Angiogenesis-related protein expression in bevacizumab-treated metastatic colorectal cancer: NOTCH1 detrimental to overall survival. PMID: 26394830 Ref: The malignant progression effects of regorafenib in human colon cancer cells. PMID: 26399347 Ref: MicroRNA-140-5p inhibits the progression of colorectal cancer by targeting VEGFA. PMID: 26402430 Ref: Cellular signaling pathways implicated in metastasis of colorectal cancer and the associated targeted agents. PMID: 26414153 Ref: Cancer-related CD15/FUT4 overexpression decreases benefit to agents targeting EGFR or VEGF acting as a novel RAF-MEK-ERK kinase downstream regulator in metastatic colorectal cancer. PMID: 26427914 Ref: [A Case of Ascending Colon Cancer Showing Marked Reduction of Ascites by Bevacizumab Combination Chemotherapy]. PMID: 26469173 Ref: Sulforaphane inhibits hypoxia-induced HIF-1alpha and VEGF expression and migration of human colon cancer cells. PMID: 26498863 Ref: Bevacizumab in combination with fluoropyrimidine-irinotecan- or fluoropyrimidine-oxaliplatin-based chemotherapy for first-line and maintenance treatment of metastatic colorectal cancer. PMID: 26506906 Ref: Molecular profiling in the treatment of colorectal cancer: focus on regorafenib. PMID: 26508880 Ref: Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways. PMID: 26517691 Ref: Radiation and SN38 treatments modulate the expression of microRNAs, cytokines and chemokines in colon cancer cells in a p53-directed manner. PMID: 26556872 Ref: Dysphonia after Bevacizumab Rechallenge: A Case Report. PMID: 26600773 Ref: Vascular endothelial growth factor -2578C/A polymorphism and colorectal cancer risk: A meta-analysis. PMID: 26664430 Ref: [RS3PE syndrome associated with senile Epstein-Barr virus-positive diffuse large B cell lymphoma of a patient with colon cancer]. PMID: 26666720 Ref: Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors. PMID: 26673922 Ref: Progranulin promotes colorectal cancer proliferation and angiogenesis through TNFR2/Akt and ERK signaling pathways. PMID: 26693061 Ref: Drug Induced Lupus Erythematosus Due to Capecitabine and Bevacizumab Treatment Presenting with Prolonged Thrombocytopenia. PMID: 26710505 Ref: Correlational research of Golgi phosphorylation protein 3 expression in colorectal cancer. PMID: 26730158 Ref: Impact of prospero homeobox-1 on tumor cell behavior and prognosis in colorectal cancer. PMID: 26807311 Ref: Quince peel polyphenolic extract blocks human colon adenocarcinoma LS174 cell growth and potentiates 5-fluorouracil efficacy. PMID: 26839513 Ref: [Effect of colon cancer cell-derived IL-1alpha on the migration and proliferation of vascular endothelial cells]. PMID: 26887509 Ref: Metabolic remodeling in human colorectal cancer and surrounding tissues: alterations in regulation of mitochondrial respiration and metabolic fluxes. PMID: 29124194 |
Ref: Glucose Transporter 1 (SLC2A1) and Vascular Endothelial Growth Factor A (VEGFA) Predict Survival After Resection of Colorectal Cancer Liver Metastasis. PMID: 25563886 Ref: LoVo colon cancer cells resistant to oxaliplatin overexpress c-MET and VEGFR-1 and respond to VEGF with dephosphorylation of c-MET. PMID: 25647613 Ref: Signaling mechanisms of resistance to EGFR- and Anti-Angiogenic Inhibitors cancer. PMID: 26364891 Ref: ALA-induced photodynamic effect on vitality, apoptosis, and secretion of vascular endothelial growth factor (VEGF) by colon cancer cells in normoxic environment in vitro. PMID: 26369606 Ref: Overexpression of forkhead box protein M1 (FOXM1) plays a critical role in colorectal cancer. PMID: 26370421 Ref: Anticancer effect of rapamycin on MCF-7 via downregulation of VEGF expression. PMID: 26427711 Ref: Comparison of (18)F-fluorodeoxyglucose PET/CT findings with vascular endothelial growth factors and receptors in colorectal cancer. PMID: 26476536 Ref: Peritumoral adipose tissue as a source of inflammatory and angiogenic factors in colorectal cancer. PMID: 26493186 Ref: Impact of KITENIN on tumor angiogenesis and lymphangiogenesis in colorectal cancer. PMID: 26496979 Ref: A prognostic classifier for patients with colorectal cancer liver metastasis, based on AURKA, PTGS2 and MMP9. PMID: 26497206 Ref: Advanced small bowel adenocarcinoma: Molecular characteristics and therapeutic perspectives. PMID: 26547136 Ref: Rationale and Design for the LUME-Colon 1 Study: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Nintedanib Plus Best Supportive Care Versus Placebo Plus Best Supportive Care in Patients With Advanced Colorectal Cancer Refractory to Stan PMID: 26603056 Ref: Does the addition of drugs targeting the vascular endothelial growth factor pathway to first-line chemotherapy increase complete response? A meta-analysis of randomized clinical trials. PMID: 26619847 Ref: Leptin, BMI, and a Metabolic Gene Expression Signature Associated with Clinical Outcome to VEGF Inhibition in Colorectal Cancer. PMID: 26626460 Ref: SIGMAR1 Regulates Membrane Electrical Activity in Response to Extracellular Matrix Stimulation to Drive Cancer Cell Invasiveness. PMID: 26645564 Ref: Clinicopathological significance of vascular endothelial growth factor, thymidine phosphorylase and microvessel density in colorectal cancer. PMID: 26676225 Ref: Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis. PMID: 26676887 Ref: Molecular Fluorescence Endoscopy Targeting Vascular Endothelial Growth Factor A for Improved Colorectal Polyp Detection. PMID: 26678613 Ref: Angiogenesis-Related Markers and Prognosis After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Metastatic Colorectal Cancer. PMID: 26727921 Ref: Mesenchymal Stem Cells Engineered to Secrete Pigment Epithelium-Derived Factor Inhibit Tumor Metastasis and the Formation of Malignant Ascites in a Murine Colorectal Peritoneal Carcinomatosis Model. PMID: 26756933 Ref: VEGF pathway targeting agents, vessel normalization and tumor drug uptake: from bench to bedside. PMID: 26789111 Ref: Splenomegaly and Its Associations with Genetic Polymorphisms and Treatment Outcome in Colorectal Cancer Patients Treated with Adjuvant FOLFOX. PMID: 26790967 Ref: Enhanced Efficacy of Doxorubicin by microRNA-499-Mediated Improvement of Tumor Blood Flow. PMID: 26797645 Ref: [Application of molecular diagnostic techniques in precision medicine of personalized treatment for colorectal cancer]. PMID: 26797832 Ref: Lack of anti-tumor activity by anti-VEGF treatments in hepatic hemangiomas. PMID: 26816001 Ref: Blocking heme oxygenase-1 by zinc protoporphyrin reduces tumor hypoxia-mediated VEGF release and inhibits tumor angiogenesis as a potential therapeutic agent against colorectal cancer. PMID: 26822586 Ref: Does bevacizumab impact anti-EGFR therapy efficacy in metastatic colorectal cancer? PMID: 26824184 Ref: microRNA-497 inhibits invasion and metastasis of colorectal cancer cells by targeting vascular endothelial growth factor-A. PMID: 26840372 Ref: Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway. PMID: 26847718 Ref: Role of OATP2A1 in PGE(2) secretion from human colorectal cancer cells via exocytosis in response to oxidative stress. PMID: 26850138 Ref: LRG1 modulates epithelial-mesenchymal transition and angiogenesis in colorectal cancer via HIF-1alpha activation. PMID: 26856989 Ref: A randomized phase 3 study on the optimization of the combination of bevacizumab with FOLFOX/OXXEL in the treatment of patients with metastatic colorectal cancer-OBELICS (Optimization of BEvacizumab scheduLIng within Chemotherapy Scheme). PMID: 26857924 Ref: Circulating Inflammatory Mediators as Potential Prognostic Markers of Human Colorectal Cancer. PMID: 26859579 Ref: Versican and vascular endothelial growth factor expression levels in peritoneal metastases from colorectal cancer are associated with survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. PMID: 26873137 Ref: Identification of approved and investigational drugs that inhibit hypoxia-inducible factor-1 signaling. PMID: 26882567 Ref: Risk factors of atherosclerosis during systemic therapy targeting vascular endothelial growth factor. PMID: 26893672 Ref: Clinical pharmacokinetics and pharmacodynamics of ramucirumab in the treatment of colorectal cancer. PMID: 26895445 Ref: A theranostic micelleplex co-delivering SN-38 and VEGF siRNA for colorectal cancer therapy. PMID: 26896610 Ref: MRI In rectal cancer: Correlations between MRI features and molecular markers Ki-67, HIF-1alpha, and VEGF. PMID: 26919464 Ref: MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome. PMID: 26921326 Ref: Palmitoylethanolamide Exerts Antiproliferative Effect and Downregulates VEGF Signaling in Caco-2 Human Colon Carcinoma Cell Line Through a Selective PPAR-alpha-Dependent Inhibition of Akt/mTOR Pathway. PMID: 26929026 Ref: Overexpression of eIF4E in colorectal cancer patients is associated with liver metastasis. PMID: 26929650 Ref: Celecoxib induces apoptosis but up-regulates VEGF via endoplasmic reticulum stress in human colorectal cancer in vitro and in vivo. PMID: 26931344 Ref: Inhibitor of growth 4 suppresses colorectal cancer growth and invasion by inducing G1 arrest, inhibiting tumor angiogenesis and reversing epithelial-mesenchymal transition. PMID: 26936485 Ref: Novel anti-angiogenic therapeutic strategies in colorectal cancer. PMID: 26938715 Ref: Down-regulation of osteoprotegerin expression as a novel biomarker for colorectal carcinoma. PMID: 26942563 Ref: The effect of celecoxib and its combination with imatinib on human HT-29 colorectal cancer cells: Involvement of COX-2, Caspase-3, VEGF and NF-kappaB genes expression. PMID: 26950454 Ref: Chronic ethanol feeding promotes azoxymethane and dextran sulfate sodium-induced colonic tumorigenesis potentially by enhancing mucosal inflammation. PMID: 26951793 Ref: Predictive biomarkers candidates for patients with metastatic colorectal cancer treated with bevacizumab-containing regimen. PMID: 26974145 Ref: The safety of monoclonal antibodies for treatment of colorectal cancer. PMID: 26982510 Ref: MicroRNA-9 suppresses cell migration and invasion through downregulation of TM4SF1 in colorectal cancer. PMID: 26983891 Ref: Intracrine VEGF Signaling Mediates the Activity of Prosurvival Pathways in Human Colorectal Cancer Cells. PMID: 26988990 Ref: Tanshinone IIA enhances chemosensitivity of colon cancer cells by suppressing nuclear factor-kappaB. PMID: 26998041 Ref: [Expression and clinical significance of kisspeptin-1, matrix metalloproteinase-2 and vascular endothelial growth factor in tissue of colon cancer]. PMID: 27005549 Ref: Paricalcitol Enhances the Chemopreventive Efficacy of 5-Fluorouracil on an Intermediate-Term Model of Azoxymethane-Induced Colorectal Tumors in Rats. PMID: 27020656 Ref: The role of semaphorin 4D as a potential biomarker for antiangiogenic therapy in colorectal cancer. PMID: 27022279 Ref: VEGF121 and VEGF165 differentially promote vessel maturation and tumor growth in mice and humans. PMID: 27033458 Ref: Effect of Recepteur d'Origine Nantais expression on chemosensitivity and tumor cell behavior in colorectal cancer. PMID: 27035413 Ref: An epitope-specific novel anti-EMMPRIN polyclonal antibody inhibits tumor progression. PMID: 27057452 Ref: CRNDE Promotes Malignant Progression of Glioma by Attenuating miR-384/PIWIL4/STAT3 Axis. PMID: 27058823 Ref: Predictive Value of Growth Factors and Interleukins for Future Liver Remnant Volume and Colorectal Liver Metastasis Volume Growth Following Portal Vein Embolization and Autologous Stem Cell Application. PMID: 27069178 Ref: MicroRNA-17~92 inhibits colorectal cancer progression by targeting angiogenesis. PMID: 27080303 Ref: Tolfenamic acid downregulates beta-catenin in colon cancer. PMID: 27089389 Ref: Soluble VEGF receptor 1 (sFLT1) induces non-apoptotic death in ovarian and colorectal cancer cells. PMID: 27103202 Ref: Angiogenesis genotyping and clinical outcome during regorafenib treatment in metastatic colorectal cancer patients. PMID: 27117754 Ref: ZKSCAN3 Facilitates Liver Metastasis of Colorectal Cancer Associated with CEA-expressing Tumor. PMID: 27127149 Ref: Scopoletin, an active principle of tree tobacco (Nicotiana glauca) inhibits human tumor vascularization in xenograft models and modulates ERK1, VEGF-A, and FGF-2 in computer model. PMID: 27133199 Ref: Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1alpha/p300 Interaction. PMID: 27140429 Ref: Markers of Response to Antiangiogenic Therapies in Colorectal Cancer: Where Are We Now and What Should Be Next? PMID: 27147901 Ref: Locally advanced rectal cancers with simultaneous occurrence of KRAS mutation and high VEGF expression show invasive characteristics. PMID: 27184911 Ref: Genes, environment and gene expression in colon tissue: a pathway approach to determining functionality. PMID: 27186328 Ref: [A Case of Advanced Colon Cancer with Long-Term and Re-Administration of Regorafenib]. PMID: 27210098 Ref: Harmal Extract Induces Apoptosis of HCT116 Human Colon Cancer Cells, Mediated by Inhibition of Nuclear Factor-kappaB and Activator Protein-1 Signaling Pathways and Induction of Cytoprotective Genes. PMID: 27221880 Ref: Ramucirumab in metastatic colorectal cancer: evidence to date and place in therapy. PMID: 27239240 Ref: Dynamic Contrast Enhanced MRI Assessing the Antiangiogenic Effect of Silencing HIF-1alpha with Targeted Multifunctional ECO/siRNA Nanoparticles. PMID: 27264671 Ref: Heterogeneity of Vascular Endothelial Growth Factor Receptors 1, 2, 3 in Primary Human Colorectal Carcinoma. PMID: 27272777 Ref: Rifaximin, a non-absorbable antibiotic, inhibits the release of pro-angiogenic mediators in colon cancer cells through a pregnane X receptor-dependent pathway. PMID: 27279570 Ref: MACC-1 Promotes Endothelium-Dependent Angiogenesis in Gastric Cancer by Activating TWIST1/VEGF-A Signal Pathway. PMID: 27280289 Ref: When a good call leads to a bad connection: colovesical fistula in colorectal cancer treated with bevacizumab. PMID: 27309405 Ref: Heterogeneous expression of zinc-finger E-box-binding homeobox 1 plays a pivotal role in metastasis via regulation of miR-200c in epithelial-mesenchymal transition. PMID: 27315529 Ref: Therapeutic Strategies in Diseases of the Digestive Tract - 2015 and Beyond Targeted Therapies in Colon Cancer Today and Tomorrow. PMID: 27332557 Ref: No associations of a set of SNPs in the Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinase (MMP) genes with survival of colorectal cancer patients. PMID: 27334288 Ref: Continuous administration of bevacizumab plus capecitabine, even after acquired resistance to bevacizumab, restored anti-angiogenic and antitumor effect in a human colorectal cancer xenograft model. PMID: 27350037 Ref: Glycine inhibits angiogenesis in colorectal cancer: role of endothelial cells. PMID: 27351202 Ref: [Effect of interleukin 17 on invasion of human colon cancer cells]. PMID: 27353107 Ref: SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin. PMID: 27353863 Ref: Gene Expression in Lipopolysaccharide-treated Human Monocytes Following Interaction with Hepatic Cancer Cells. PMID: 27354643 Ref: Aflibercept, a New Way to Target Angiogenesis in the Second Line Treatment of Metastatic Colorectal Cancer (mCRC). PMID: 27412031 Ref: HIF-1alpha expression and high microvessel density are characteristic features in serrated colorectal cancer. PMID: 27421843 Ref: Expression of Endoglin and Vascular Endothelial Growth Factor as Prognostic Markers in Experimental Colorectal Cancer. PMID: 27466499 Ref: Total and not bevacizumab-bound vascular endothelial growth factor as potential predictive factors to bevacizumab-based chemotherapy in colorectal cancer. PMID: 27468218 Ref: Thymoquinone subdues tumor growth and potentiates the chemopreventive effect of 5-fluorouracil on the early stages of colorectal carcinogenesis in rats. PMID: 27468227 Ref: CD24 promoted cancer cell angiogenesis via Hsp90-mediated STAT3/VEGF signaling pathway in colorectal cancer. PMID: 27494878 Ref: DDA suppresses angiogenesis and tumor growth of colorectal cancer in vivo through decreasing VEGFR2 signaling. PMID: 27517319 Ref: p53 functional deficiency in human colon cancer cells promotes fibroblast-mediated angiogenesis and tumor growth. PMID: 27520561 Ref: Pregnancy-specific glycoprotein 9 (PSG9), a driver for colorectal cancer, enhances angiogenesis via activation of SMAD4. PMID: 27528036 Ref: Acute tumour response to a bispecific Ang-2-VEGF-A antibody: insights from multiparametric MRI and gene expression profiling. PMID: 27529514 Ref: Erythropoietin accelerates tumor growth through increase of erythropoietin receptor (EpoR) as well as by the stimulation of angiogenesis in DLD-1 and Ht-29 xenografts. PMID: 27543111 Ref: Rab27A mediated by NF-kappaB promotes the stemness of colon cancer cells via up-regulation of cytokine secretion. PMID: 27556511 Ref: gamma-Tocotrienol suppresses growth and sensitises human colorectal tumours to capecitabine in a nude mouse xenograft model by down-regulating multiple molecules. PMID: 27575851 Ref: A Novel Malate Dehydrogenase 2 Inhibitor Suppresses Hypoxia-Inducible Factor-1 by Regulating Mitochondrial Respiration. PMID: 27611801 Ref: Multisciplinary management of patients with liver metastasis from colorectal cancer. PMID: 27621569 Ref: Exclusive inhibition of PI3K/Akt/mTOR signaling is not sufficient to prevent PDGF-mediated effects on glycolysis and proliferation in colorectal cancer. PMID: 27626684 Ref: RUNX3 inhibits the metastasis and angiogenesis of colorectal cancer. PMID: 27633042 Ref: Rectal cancer: Neoadjuvant chemoradiotherapy. PMID: 27644910 Ref: Efficacy of Cotargeting Angiopoietin-2 and the VEGF Pathway in the Adjuvant Postsurgical Setting for Early Breast, Colorectal, and Renal Cancers. PMID: 27651308 Ref: Role of targeted therapy in metastatic colorectal cancer. PMID: 27672422 Ref: Reduced Representation Bisulfite Sequencing Determination of Distinctive DNA Hypermethylated Genes in the Progression to Colon Cancer in African Americans. PMID: 27688749 Ref: Thymoquinone chemosensitizes colon cancer cells through inhibition of NF-kappaB. PMID: 27698868 Ref: Randomized study of FOLFIRI plus either panitumumab or bevacizumab for wild-type KRAS colorectal cancer-WJOG 6210G. PMID: 27712015 Ref: Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer. PMID: 27721235 Ref: Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model. PMID: 27729020 Ref: Expression of VEGF-D, SMAD4, and SMAD7 and Their Relationship with Lymphangiogenesis and Prognosis in Colon Cancer. PMID: 27730400 Ref: Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases. PMID: 27733559 Ref: Unresectable liver metastases in colorectal cancer: review of current strategies. PMID: 27733753 Ref: MiR-590-5p inhibits colorectal cancer angiogenesis and metastasis by regulating nuclear factor 90/vascular endothelial growth factor A axis. PMID: 27735951 Ref: Preclinical validation of the small molecule drug quininib as a novel therapeutic for colorectal cancer. PMID: 27739445 Ref: Filamin A interacting protein 1-like expression inhibits progression in colorectal cancer. PMID: 27750216 Ref: Chemotherapeutic potentials of the stem bark of Balanite aegyptiaca (L.) Delile: an antiangiogenic, antitumor and antioxidant agent. PMID: 27760539 Ref: Effect of colorectal cancer on the number of normal stem cells circulating in peripheral blood. PMID: 27779706 Ref: Low dose angiostatic treatment counteracts radiotherapy-induced tumor perfusion and enhances the anti-tumor effect. PMID: 27780936 Ref: Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity. PMID: 27791128 Ref: Biomarker-Based Scoring System for Prediction of Tumor Response After Preoperative Chemoradiotherapy in Rectal Cancer by Reverse Transcriptase Polymerase Chain Reaction Analysis. PMID: 27824703 Ref: Hypoxic resistance of KRAS mutant tumor cells to 3-Bromopyruvate is counteracted by Prima-1 and reversed by N-acetylcysteine. PMID: 27863474 Ref: Targeted Therapy of Colorectal Cancer. PMID: 27889786 Ref: Chemoprevention of Colon Cancer through Inhibition of Angiogenesis and Induction of Apoptosis by Nonsteroidal Anti-Inflammatory Drugs. PMID: 27910782 Ref: Endogenous erythropoietin and erythropoietin receptors in colorectal cancer; can we answer the questions? PMID: 27959268 Ref: Immunotherapy of colorectal cancer: new perspectives after a long path. PMID: 27993089 Ref: Yttrium-90 radioembolization for colorectal cancer liver metastases: a prospective cohort study on circulating angiogenic factors and treatment response. PMID: 28004357 Ref: [Target Therapy in Unresectable or Metastatic Colorectal Cancer]. PMID: 28025473 Ref: [Effect of jianpi-jiedu formula on tumor angiogenesis-relevant genes expression in colorectal cancer]. PMID: 28070042 Ref: Comparison of Anticancer Effects of Carbamazepine and Valproic Acid. PMID: 28184324 Ref: Peritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization of the tumor microenvironment inducing senescence and proliferation arrest in cancer cells. PMID: 28439450 Ref: Large Skin Ulcer Due to a Subcutaneous Orthopaedic Implant After Bevacizumab Therapy: A Case Report. PMID: 29252647 |
Ref: Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression. PMID: 26824338 Ref: Novel synthetic curcumin analogs as potent antiangiogenic agents in colorectal cancer. PMID: 27128654 Ref: Dysregulation of EGFR Pathway in EphA2 Cell Subpopulation Significantly Associates with Poor Prognosis in Colorectal Cancer. PMID: 27401248 Ref: Garcinol exhibits anti-proliferative activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells. PMID: 27481098 Ref: Targeting acid sphingomyelinase with anti-angiogenic chemotherapy. PMID: 27702691 Ref: Expression of angiogenic growth factors VEGF, bFGF and ANG1 in colon cancer after bevacizumab treatment in vitro: A potential self-regulating mechanism. PMID: 27840995 Ref: Simvastatin inhibits tumor angiogenesis in HER2-overexpressing human colorectal cancer. PMID: 27887848 Ref: Germline polymorphisms as biomarkers of tumor response in colorectal cancer patients treated with anti-EGFR monoclonal antibodies: a systematic review and meta-analysis. PMID: 27897268 Ref: Biology and therapeutic implications of VEGF-A splice isoforms and single-nucleotide polymorphisms in colorectal cancer. PMID: 27943279 Ref: A 15-gene signature for prediction of colon cancer recurrence and prognosis based on SVM. PMID: 27998790 Ref: Unlocking Aspirin's Chemopreventive Activity: Role of Irreversibly Inhibiting Platelet Cyclooxygenase-1. PMID: 27998883 Ref: The VEGFR Inhibitor Cediranib Improves the Efficacy of Fractionated Radiotherapy in a Colorectal Cancer Xenograft Model. PMID: 28002822 Ref: Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2. PMID: 28035050 Ref: CCL24 contributes to HCC malignancy via RhoB- VEGFA-VEGFR2 angiogenesis pathway and indicates poor prognosis. PMID: 28042950 Ref: Targeting the PD-1 pathway: a new hope for gastrointestinal cancers. PMID: 28055269 Ref: Long non-coding RNA growth arrest specific transcript 5 acts as a tumour suppressor in colorectal cancer by inhibiting interleukin-10 and vascular endothelial growth factor expression. PMID: 28099146 Ref: A phase I and pharmacokinetic study of afilbercept with FOLFIRI: comparison of Chinese and Caucasian populations. PMID: 28102464 Ref: Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer. PMID: 28106826 Ref: Targeted Theranostics Against Solid Cancer Using Metal Bond Milk Protein and Aptamers. PMID: 28137239 Ref: Immunotherapy for the treatment of colorectal tumors: focus on approved and in-clinical-trial monoclonal antibodies. PMID: 28138221 Ref: Macrophage migration inhibitory factor siRNA inhibits hepatic metastases of colorectal cancer cells. PMID: 28199208 Ref: Six1 promotes colorectal cancer growth and metastasis by stimulating angiogenesis and recruiting tumor-associated macrophages. PMID: 28199476 Ref: Oncogenic role of PDK4 in human colon cancer cells. PMID: 28208156 Ref: The effect of vascular endothelial growth factor-1 expression on survival of advanced colorectal cancer patients. PMID: 28245709 Ref: Prognostic significance of vascular endothelial growth factor polymorphisms in colorectal cancer patients. PMID: 28255429 Ref: The impact of the RBM4-initiated splicing cascade on modulating the carcinogenic signature of colorectal cancer cells. PMID: 28276498 Ref: Effects of di(2-ethylhexyl)phthalate exposure on 1,2-dimethyhydrazine-induced colon tumor promotion in rats. PMID: 28284729 Ref: Homeobox B9 Mediates Resistance to Anti-VEGF Therapy in Colorectal Cancer Patients. PMID: 28298545 Ref: Assessment of histone tail modifications and transcriptional profiling during colon cancer progression reveals a global decrease in H3K4me3 activity. PMID: 28315775 Ref: KRAS and VEGF gene 3'-UTR single nucleotide polymorphisms predicted susceptibility in colorectal cancer. PMID: 28328959 Ref: Thymoquinone potentiates chemoprotective effect of Vitamin D3 against colon cancer: a pre-clinical finding. PMID: 28337306 Ref: Colorectal polypoid lesions and expression of vascular endothelial growth factor in a consecutive series of endoscopic and surgical patients. PMID: 28347226 Ref: Phase II study of the Multikinase inhibitor of angiogenesis, Linifanib, in patients with metastatic and refractory colorectal cancer expressing mutated KRAS. PMID: 28353122 Ref: VEGF, Flt-1, and microvessel density in primary tumors as predictive factors of colorectal cancer prognosis. PMID: 28357103 Ref: Plasticity of Resistance and Sensitivity to Anti-Epidermal Growth Factor Receptor Inhibitors in Metastatic Colorectal Cancer. PMID: 28382467 Ref: Phase I trial and pharmacokinetic study of tanibirumab, a fully human monoclonal antibody to vascular endothelial growth factor receptor 2, in patients with refractory solid tumors. PMID: 28391576 Ref: Vascular endothelial growth factor A amplification in colorectal cancer is associated with reduced M1 and M2 macrophages and diminished PD-1-expressing lymphocytes. PMID: 28403223 Ref: Elevated TATA-binding protein expression drives vascular endothelial growth factor expression in colon cancer. PMID: 28415573 Ref: The changes of tumour vascular endothelial growth factor expression after neoadjuvant chemoradiation in patients with rectal adenocarcinoma. PMID: 28435398 Ref: MicroRNA-140-5p inhibits cell proliferation and invasion by regulating VEGFA/MMP2 signaling in glioma. PMID: 28443475 Ref: Smad4 Inhibits VEGF-A and VEGF-C Expressions via Enhancing Smad3 Phosphorylation in Colon Cancer. PMID: 28445620 Ref: Role of RAS mutation status as a prognostic factor for patients with advanced colorectal cancer treated with first-line chemotherapy based on fluoropyrimidines and oxaliplatin, with or without bevavizumab: A retrospective analysis. PMID: 28451421 Ref: CXCL1 Is Critical for Premetastatic Niche Formation and Metastasis in Colorectal Cancer. PMID: 28455419 Ref: Establishment of human metastatic colorectal cancer model in rabbit liver: A pilot study. PMID: 28475639 Ref: Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer. PMID: 28487489 Ref: MicroRNA-30a-5p (miR-30a) regulates cell motility and EMT by directly targeting oncogenic TM4SF1 in colorectal cancer. PMID: 28528497 Ref: An Oncolytic Adenovirus Encoding Decorin and Granulocyte Macrophage Colony Stimulating Factor Inhibits Tumor Growth in a Colorectal Tumor Model by Targeting Pro-Tumorigenic Signals and via Immune Activation. PMID: 28530155 Ref: Maculopapular rash after intravitreal injection of an antivascular endothelial growth factor, aflibercept, for treating age-related macular degeneration: A case report. PMID: 28538392 Ref: Methanolic extract of Boswellia serrata exhibits anti-cancer activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells. PMID: 28549801 Ref: Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1alpha and VEGF receptors. PMID: 28594907 Ref: Right- vs. Left-Sided Metastatic Colorectal Cancer: Differences in Tumor Biology and Bevacizumab Efficacy. PMID: 28598398 Ref: Clinical analysis of bevacizumab targeting therapy in treating early colorectal carcinoma after operation. PMID: 28599469 Ref: Tanshinone IIA inhibits beta-catenin/VEGF-mediated angiogenesis by targeting TGF-beta1 in normoxic and HIF-1alpha in hypoxic microenvironments in human colorectal cancer. PMID: 28602978 Ref: CRH promotes human colon cancer cell proliferation via IL-6/JAK2/STAT3 signaling pathway and VEGF-induced tumor angiogenesis. PMID: 28618089 Ref: Profile of gene expression of TLR-signaling pathways in colorectal cancer tissues. PMID: 28627973 Ref: Protracted Inhibition of Vascular Endothelial Growth Factor Signaling Improves Survival in Metastatic Colorectal Cancer: A Systematic Review. PMID: 28680835 Ref: Profiling of cytokines, chemokines and other soluble proteins as a potential biomarker in colorectal cancer and polyps. PMID: 28689023 Ref: Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy. PMID: 28691930 Ref: Optimal use of anti-EGFR monoclonal antibodies for patients with advanced colorectal cancer: a meta-analysis. PMID: 28695301 Ref: Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer. PMID: 28714940 Ref: Antiangiogenic tyrosine kinase inhibitors in colorectal cancer: is there a path to making them more effective? PMID: 28721456 Ref: The IGF1R/INSR Inhibitor BI 885578 Selectively Inhibits Growth of IGF2-Overexpressing Colorectal Cancer Tumors and Potentiates the Efficacy of Anti-VEGF Therapy. PMID: 28729397 Ref: Primary and acquired resistance to biologic therapies in gastrointestinal cancers. PMID: 28736637 Ref: MicroRNA-299-3p suppresses proliferation and invasion by targeting VEGFA in human colon carcinoma. PMID: 28738498 Ref: Intracrine VEGF signalling mediates colorectal cancer cell migration and invasion. PMID: 28742793 Ref: 15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1. PMID: 28757355 Ref: TAS-102 plus bevacizumab for patients with metastatic colorectal cancer refractory to standard therapies (C-TASK FORCE): an investigator-initiated, open-label, single-arm, multicentre, phase 1/2 study. PMID: 28760399 Ref: R-spondin 2 promotes proliferation and migration via the Wnt/beta-catenin pathway in human hepatocellular carcinoma. PMID: 28789406 Ref: Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites. PMID: 28790461 Ref: Classical VEGF, Notch and Ang signalling in cancer angiogenesis, alternative approaches and future directions (Review). PMID: 28791360 Ref: Catalpol suppressed proliferation, growth and invasion of CT26 colon cancer by inhibiting inflammation and tumor angiogenesis. PMID: 28826099 Ref: VEGFR2 regulates endothelial differentiation of colon cancer cells. PMID: 28854900 Ref: Potential Application of Eicosapentaenoic Acid Monoacylglyceride in the Management of Colorectal Cancer. PMID: 28869531 Ref: Circulating Levels of VEGF and CXCL1 Are Predictive of Metastatic Organotropismin in Patients with Colorectal Cancer. PMID: 28870907 Ref: BRG1 promotes VEGF-A expression and angiogenesis in human colorectal cancer cells. PMID: 28899659 Ref: Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer. PMID: 28900008 Ref: Identification of hypoxia-regulated angiogenic genes in colorectal cancer. PMID: 28928094 Ref: In Surgical Colon Cancer Patients Extended-Duration Thromboprophylaxis (30 days) with the Highest Dose of Tinzaparin (4,500 IU s.c./q.d.) Normalizes the Postoperative VEGF Levels. PMID: 28928880 Ref: Predictive clinical model of tumor response after chemoradiation in rectal cancer. PMID: 28938543 Ref: Sialyllactose suppresses angiogenesis by inhibiting VEGFR-2 activation, and tumor progression. PMID: 28938544 Ref: A transcriptome-based protein network that identifies new therapeutic targets in colorectal cancer. PMID: 28962550 Ref: Bevacizumab-Related Microvascular Angina and Its Management with Nicorandil. PMID: 28966326 Ref: Targeted first-line therapies for advanced colorectal cancer: a Bayesian meta-analysis. PMID: 29029527 Ref: 5,6-dehydrokawain from the rhizome of Alpinia mutica Roxb. induced proangiogenic tumour-derived VEGF of HT-29 colorectal cancer. PMID: 29052437 Ref: Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production. PMID: 29078273 Ref: Prohibitin, relocated to the front ends, can control the migration directionality of colorectal cancer cells. PMID: 29100316 Ref: STK33 participates to HSP90-supported angiogenic program in hypoxic tumors by regulating HIF-1alpha/VEGF signaling pathway. PMID: 29100402 Ref: Role of VEGF, CD105, and CD31 in the Prognosis of Colorectal Cancer Cases. PMID: 29110224 Ref: Lactoferrin Exerts Antitumor Effects by Inhibiting Angiogenesis in a HT29 Human Colon Tumor Model. PMID: 29112400 Ref: GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions. PMID: 29137421 Ref: Potentiation of treatment efficacy against colon cancer of dopamine via elevating KLF2 expression in tumor vascular endothelial cells. PMID: 29164576 Ref: (64)Cu-ATSM internal radiotherapy to treat tumors with bevacizumab-induced vascular decrease and hypoxia in human colon carcinoma xenografts. PMID: 29179478 Ref: Recombinant human endostatin combined with radiotherapy inhibits colorectal cancer growth. PMID: 29282026 Ref: Role of VEGFA gene polymorphisms in colorectal cancer patients who treated with bevacizumab. PMID: 29285265 Ref: Curcumin-Free Turmeric Exhibits Activity against Human HCT-116 Colon Tumor Xenograft: Comparison with Curcumin and Whole Turmeric. PMID: 29311914 Ref: LncRNA SUMO1P3 drives colon cancer growth, metastasis and angiogenesis. PMID: 29312498 |
Ref: Histamine and Histaminergic Receptors in Colorectal Cancer: From Basic Science to Evidence-based Medicine. PMID: 26996193 Ref: Metastatic Colorectal Cancer: Role of Target Therapies and Future Perspectives. PMID: 28183254 Ref: Antiproliferative activity of vitexin-2-O-xyloside and avenanthramides on CaCo-2 and HepG2 cancer cells occurs through apoptosis induction and reduction of pro-survival mechanisms. PMID: 28283822 Ref: Postoperative serum Vascular Endothelial Growth Factor is an independent prognostic factor of disease free survival and overall survival in patients with non metastatic colon cancer. PMID: 28683891 Ref: The extracellular matrix protein mindin attenuates colon cancer progression by blocking angiogenesis via Egr-1-mediated regulation. PMID: 28991232 Ref: Secretion of the angiogenic factor VEGF after photodynamic therapy with ALA under hypoxia-like conditions in colon cancer cells. PMID: 29079348 Ref: Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents. PMID: 29084916 Ref: CCR6 promotes tumor angiogenesis via the AKT/NF-kappaB/VEGF pathway in colorectal cancer. PMID: 29097259 Ref: Monoclonal Antibodies Targeting the IL-17/IL-17RA Axis: An Opportunity to Improve the Efficiency of Anti-VEGF Therapy in Fighting Metastatic Colorectal Cancer? PMID: 29153431 Ref: Fibroblast activation protein-alpha in tumor cells promotes colorectal cancer angiogenesis via the Akt and ERK signaling pathways. PMID: 29207091 Ref: Overexpression of miR-19a inhibits colorectal cancer angiogenesis by suppressing KRAS expression. PMID: 29207158 Ref: First-in-Human Phase I Study of Single-agent Vanucizumab, A First-in-Class Bispecific Anti-Angiopoietin-2/Anti-VEGF-A Antibody, in Adult Patients with Advanced Solid Tumors. PMID: 29217526 Ref: Adipose-derived stem cells decrease pain in a rat model of oxaliplatin-induced neuropathy: Role of VEGF-A modulation. PMID: 29241656 Ref: Protein Expression and Genetic Variation of IL32 and Association with Colorectal Cancer in Swedish Patients. PMID: 29277790 Ref: Genetic variants in the VEGF pathway as prognostic factors in stages II and III colon cancer. PMID: 29282362 Ref: Emodin inhibits colon cancer cell invasion and migration by suppressing epithelialmesenchymal transition via the Wnt/beta-catenin pathway. PMID: 29301594 Ref: Inhibition of VEGF-dependent angiogenesis and tumor angiogenesis by an optimized antibody targeting CLEC14a. PMID: 29316206 Ref: RNA interference-mediated silencing of aquaporin (AQP)-5 hinders angiogenesis of colorectal tumor by suppressing the production of vascular endothelial growth factor. PMID: 29322789 Ref: The role of tumor angiogenesis as a therapeutic target in colorectal cancer. PMID: 29338550 Ref: Histopathological growth patterns as a candidate biomarker for immunomodulatory therapy. PMID: 29355613 Ref: Anti-tumor effects of ONC201 in combination with VEGF-inhibitors significantly impacts colorectal cancer growth and survival in vivo through complementary non-overlapping mechanisms. PMID: 29357916 Ref: miR-144 inhibits growth and metastasis of cervical cancer cells by targeting VEGFA and VEGFC. PMID: 29387205 Ref: Napabucasin versus placebo in refractory advanced colorectal cancer: a randomised phase 3 trial. PMID: 29397354 Ref: Subsequent anti-VEGF therapy after first-line anti-EGFR therapy improved overall survival of patients with metastatic colorectal cancer. PMID: 29403291 Ref: Randomized Phase II Trial of Parsatuzumab (Anti-EGFL7) or Placebo in Combination with Carboplatin, Paclitaxel, and Bevacizumab for First-Line Nonsquamous Non-Small Cell Lung Cancer. PMID: 29438092 Ref: Optimizing the use of anti VEGF targeted therapies in patients with metastatic colorectal cancer: review of literature. PMID: 29440946 Ref: Deciphering the biochemical and molecular mechanism underlying the in vitro and in vivo chemotherapeutic efficacy of ruthenium quercetin complex in colon cancer. PMID: 29442390 Ref: Discontinuous Schedule of Bevacizumab in Colorectal Cancer Induces Accelerated Tumor Growth and Phenotypic Changes. PMID: 29459325 Ref: Construction of key signal regulatory network in metastatic colorectal cancer. PMID: 29464057 Ref: Preliminary Study of the Role F-Box Protein 32 (FBXO32) in Colorectal Neoplasms Through the Transforming Growth Factor beta (TGF-beta)/Smad4 Signalling Pathway. PMID: 29465067 Ref: Combinations of Bevacizumab and Erlotinib Show Activity in Colorectal Cancer Independent of RAS Status. PMID: 29490990 Ref: VEGF pathway-targeting drugs induce evasive adaptation by activation of neuropilin-1/cMet in colon cancer cells. PMID: 29532881 Ref: Anti-Angiogenics: Their Value in Colorectal Cancer Therapy. PMID: 29562227 Ref: Deciphering the molecular mechanism and apoptosis underlying the in-vitro and in-vivo chemotherapeutic efficacy of vanadium luteolin complex in colon cancer. PMID: 29574863 Ref: Molecular Testing for the Treatment of Advanced Colorectal Cancer: An Overview. PMID: 29589315 Ref: Genipin inhibits the invasion and migration of colon cancer cells by the suppression of HIF-1alpha accumulation and VEGF expression. PMID: 29630948 Ref: Prognostic Value of ACVRL1 Expression in Metastatic Colorectal Cancer Patients Receiving First-line Chemotherapy With Bevacizumab: Results From the Triplet Plus Bevacizumab (TRIBE) Study. PMID: 29636300 Ref: Loss of neutrophil polarization in colon carcinoma liver metastases of mice with an inducible, liver-specific IGF-I deficiency. PMID: 29644002 Ref: Tea Polysaccharides Inhibit Colitis-Associated Colorectal Cancer via Interleukin-6/STAT3 Pathway. PMID: 29656647 Ref: Peroxiredoxin 1 promoted tumor metastasis and angiogenesis in colorectal cancer. PMID: 29673884 Ref: Synergistic antitumor effects of cMet inhibitor in combination with anti-VEGF in colorectal cancer patient-derived xenograft models. PMID: 29675102 Ref: Immunohistochemical Expression of Fatty Acid Synthase and Vascular Endothelial Growth Factor in Primary Colorectal Cancer: a Clinicopathological Study. PMID: 29681001 Ref: Polysaccharide from Rhizopus nigricans inhibits the invasion and metastasis of colorectal cancer. PMID: 29684852 Ref: Multi-panel assay of serum autoantibodies in colorectal cancer. PMID: 29691673 Ref: MicroRNA125 inhibits RKO colorectal cancer cell growth by targeting VEGF. PMID: 29693153 Ref: Potential of siRNA-albumin complex against cancer. PMID: 29709588 Ref: Histogram analysis of ADC in rectal cancer: associations with different histopathological findings including expression of EGFR, Hif1-alpha, VEGF, p53, PD1, and KI 67. A preliminary study. PMID: 29719621 Ref: Development of a novel albumin-based and maleimidopropionic acid-conjugated peptide with prolonged half-life and increased in vivo anti-tumor efficacy. PMID: 29721065 Ref: Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. PMID: 29728604 Ref: MicroRNA-181a promotes angiogenesis in colorectal cancer by targeting SRCIN1 to promote the SRC/VEGF signaling pathway. PMID: 29739921 Ref: Molecular targets of Chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology. PMID: 29740162 Ref: Association Between c-Met and Lymphangiogenic Factors in Patients With Colorectal Cancer. PMID: 29742856 Ref: Ginsenoside Rg3 Sensitizes Colorectal Cancer to Radiotherapy through Downregulation of Proliferative and Angiogenic Biomarkers. PMID: 29743919 Ref: The safety of trifluridine and tipiracil for the treatment of metastatic colorectal cancer. PMID: 29745737 Ref: Angiogenin and the MMP9-TIMP2 axis are up-regulated in proangiogenic, decidual NK-like cells from patients with colorectal cancer. PMID: 29763380 Ref: The evolving role of immune oncology in colorectal cancer. PMID: 29764162 Ref: Bevacizumab exacerbates sinusoidal obstruction syndrome (SOS) in the animal model and increases MMP 9 production. PMID: 29774103 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: lncRNA CCAT1 promotes cell proliferation, migration, and invasion by down-regulation of miR-143 in FTC-133 thyroid carcinoma cell line. PMID: 29791590 Ref: Role of Kupffer cells in the progression of CRC liver metastases after the first stage of ALPPS. PMID: 29795479 Ref: Subsite heterogeneity in the profiles of circulating cytokines in colorectal cancer. PMID: 29801973 Ref: miR1 inhibits the progression of colon cancer by regulating the expression of vascular endothelial growth factor. PMID: 29845255 Ref: Expression profile of NF-kappaB regulated genes in sporadic colorectal cancer patients. PMID: 29849793 Ref: Angiodrastic Chemokines in Colorectal Cancer: Clinicopathological Correlations. PMID: 29850390 Ref: Jianpi Jiedu decoction, a traditional Chinese medicine formula, inhibits tumorigenesis, metastasis, and angiogenesis through the mTOR/HIF-1alpha/VEGF pathway. PMID: 29852266 Ref: The role of glycosyltransferase enzyme GCNT3 in colon and ovarian cancer prognosis and chemoresistance. PMID: 29855486 Ref: Verbascoside attenuates Rac-1 and HIF-1alpha signaling cascade in colorectal cancer cells. PMID: 29886834 Ref: Anti-angiogenic treatment (Bevacizumab) improves the responsiveness of photodynamic therapy in colorectal cancer. PMID: 29894822 Ref: Laminin alpha1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma. PMID: 29907957 Ref: Research progress on common adverse events caused by targeted therapy for colorectal cancer. PMID: 29928383 Ref: A Systems-Level Analysis Reveals Circadian Regulation of Splicing in Colorectal Cancer. PMID: 29936137 Ref: Regorafenib: A Review in Metastatic Colorectal Cancer. PMID: 29943375 Ref: Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic Colorectal Cancer: The FRESCO Randomized Clinical Trial. PMID: 29946728 Ref: Sex-dependent correlation between survival and expression of genes related to the circadian oscillator in patients with colorectal cancer. PMID: 29953268 Ref: ATAD2 silencing decreases VEGFA secretion through targeting has-miR-520a to inhibit angiogenesis in colorectal cancer. PMID: 29958090 Ref: Treatment effect of conversion therapy and its correlation with VEGF expression in unresectable rectal cancer with liver metastasis. PMID: 29963141 Ref: Cytotoxic effect of 2, 5-dimethyl-celecoxib as a structural analog of celecoxib on human colorectal cancer (HT-29) cell line. PMID: 29974839 Ref: Modification of alpha2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway. PMID: 29981167 Ref: Korean Red Ginseng extract reduces hypoxia-induced epithelial-mesenchymal transition by repressing NF-kappaB and ERK1/2 pathways in colon cancer. PMID: 29983610 Ref: Silencing NIK potentiates anti-VEGF therapy in a novel 3D model of colorectal cancer angiogenesis. PMID: 29983872 Ref: Angiogenesis and vasculogenic mimicry are inhibited by 8-Br-cAMP through activation of the cAMP/PKA pathway in colorectal cancer. PMID: 29997437 Ref: Inhibitory effect of icariin on osteosarcoma cell proliferation via the Wnt/beta-catenin signaling pathway. PMID: 30008817 Ref: Targeted therapy for metastatic colorectal cancer. PMID: 30019590 Ref: Association Between Hypoxia-Inducible Factor-2alpha (HIF-2alpha) Expression and Colorectal Cancer and Its Prognostic Role: a Systematic Analysis. PMID: 30021192 Ref: Cabozantinib exhibits potent antitumor activity in colorectal cancer patient-derived tumor xenograft models via autophagy and signaling mechanisms. PMID: 30026382 Ref: Osteoglycin-induced VEGF Inhibition Enhances T Lymphocytes Infiltrating in Colorectal Cancer. PMID: 30037719 Ref: Sulforaphane, a Chemopreventive Compound, Inhibits Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Expression in Human HT-29 Colon Cancer Cells. PMID: 30041241 Ref: Immune Landscape of Colorectal Cancer Tumor Microenvironment from Different Primary Tumor Location. PMID: 30042763 Ref: Upregulation of RASSF1A in Colon Cancer by Suppression of Angiogenesis Signaling and Akt Activation. PMID: 30045022 Ref: NOX4, A New Genetic Target for Anti-cancer Therapy in Digestive System Cancer. PMID: 30058122 Ref: Tim-4 promotes the growth of colorectal cancer by activating angiogenesis and recruiting tumor-associated macrophages via the PI3K/AKT/mTOR signaling pathway. PMID: 30118845 Ref: Antitumor Effects of Umbelliprenin in a Mouse Model of Colorectal Cancer. PMID: 30127820 Ref: MiRNA-206 suppresses PGE2-induced colorectal cancer cell proliferation, migration, and invasion by targetting TM4SF1. PMID: 30135139 Ref: Colonic stent-induced mechanical compression may suppress cancer cell proliferation in malignant large bowel obstruction. PMID: 30171397 Ref: Risk of bleeding associated with antiangiogenic monoclonal antibodies bevacizumab and ramucirumab: a meta-analysis of 85 randomized controlled trials. PMID: 30174444 Ref: Cardiotoxicity with vascular endothelial growth factor inhibitor therapy. PMID: 30202791 Ref: Matricellular protein periostin promotes colitis-associated colon tumorigenesis in mice. PMID: 30204842 Ref: Sorcin a Potential Molecular Target for Cancer Therapy. PMID: 30216763 Ref: 4'-hydroxywogonin inhibits colorectal cancer angiogenesis by disrupting PI3K/AKT signaling. PMID: 30217479 Ref: Formin-like 3 regulates RhoC/FAK pathway and actin assembly to promote cell invasion in colorectal carcinoma. PMID: 30228782 Ref: SP1-induced lncRNA-ZFAS1 contributes to colorectal cancer progression via the miR-150-5p/VEGFA axis. PMID: 30250022 Ref: FOXF1 promotes angiogenesis and accelerates bevacizumab resistance in colorectal cancer by transcriptionally activating VEGFA. PMID: 30253191 Ref: Glycyrrhizic acid suppresses 1,2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats: Alleviation of inflammatory, proliferation, angiogenic, and apoptotic markers. PMID: 30255981 Ref: Suppression of angiogenesis and tumor growth by recombinant T4 phages displaying extracellular domain of vascular endothelial growth factor receptor 2. PMID: 30259141 Ref: A molecular basis for the synergy between 17allylamino17demethoxy geldanamycin with Capecitabine and Irinotecan in human colorectal cancer cells through VEFG and MMP-9 gene expression. PMID: 30315927 Ref: Body fatness, adipose tissue compartments and biomarkers of inflammation and angiogenesis in colorectal cancer: the ColoCare Study. PMID: 30333223 Ref: Gold nanoparticles enhance cisplatin delivery and potentiate chemotherapy by decompressing colorectal cancer vessels. PMID: 30349245 Ref: Role of miRNA-210, miRNA-21 and miRNA-126 as diagnostic biomarkers in colorectal carcinoma: impact of HIF-1alpha-VEGF signaling pathway. PMID: 30357530 Ref: An Intrinsic Mitochondrial Pathway Is Required for Phytic Acid-Chitosan-Iron Oxide Nanocomposite (Phy-CS-MNP) to Induce G(0)/G(1) Cell Cycle Arrest and Apoptosis in the Human Colorectal Cancer (HT-29) Cell Line. PMID: 30360519 Ref: Non-target Genes Regulate miRNAs-Mediated Migration Steering of Colorectal Carcinoma. PMID: 30361904 Ref: Tumour-infiltrating neutrophils counteract anti-VEGF therapy in metastatic colorectal cancer. PMID: 30377339 Ref: Tauroursodeoxycholic acid attenuates colitis-associated colon cancer by inhibiting nuclear factor kappaB signaling. PMID: 30378164 |