Primary Site >> Colorectal Cancer
Gene >> TP53
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Ref: Growth-dependent expression of human Mr 53,000 tumor antigen messenger RNA in normal and neoplastic cells. PMID: 3019534 Ref: Elevated levels of p53 antigen in cultured skin fibroblasts from patients with hereditary adenocarcinoma of the colon and rectum and its relevance to oncogenic mechanisms. PMID: 3467115 |
Ref: Oncogene expression in adenocarcinomas of the colon and in colon tumor-derived cell lines. PMID: 3282475 Ref: Biological characterization and oncogene expression in human colorectal carcinoma cell lines. PMID: 3338874 |
Ref: Genetic analysis of colorectal cancer. PMID: 2562187 Ref: The evidence for human tumor suppressor genes. PMID: 2577336 Ref: Expression of c-myc oncogene in colorectal polyps as a biological marker for monitoring malignant potential. PMID: 2743265 |
Ref: p53 mutations in colorectal cancer. PMID: 1699228 Ref: Deletion mapping of the medulloblastoma locus on chromosome 17p. PMID: 1979050 Ref: The genetics of colorectal cancer. PMID: 2101725 Ref: Suppression of human colorectal carcinoma cell growth by wild-type p53. PMID: 2144057 Ref: Growth factors and oncogenes in human gastrointestinal carcinomas. PMID: 2157713 Ref: Lessons from the genetics of colon cancer. PMID: 2173130 Ref: [A joint study of mutation of the Ki-ras oncogene and overexpression of the Tp53 oncogene in colorectal cancer]. PMID: 2190855 Ref: Comparison of salsalate and aspirin on mucosal injury and gastroduodenal mucosal prostaglandins. PMID: 2227277 Ref: p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. PMID: 2253215 Ref: Risk and surveillance of individuals with heritable factors for colorectal cancer. WHO Collaborating Centre for the Prevention of Colorectal Cancer. PMID: 2289301 |
Ref: Mutations of the P53 gene, including an intronic point mutation, in colorectal tumors. PMID: 1647768 Ref: The p53 gene is very frequently mutated in small-cell lung cancer with a distinct nucleotide substitution pattern. PMID: 1656362 Ref: Are there molecular targets for therapy of colon cancer? PMID: 1664228 Ref: Association of nm23-H1 allelic deletions with distant metastases in colorectal carcinoma. PMID: 1679868 Ref: Immunohistochemical analysis of p53 and HER-2/neu proteins in human tumors. PMID: 1680897 Ref: p53 expression in colorectal tumors. PMID: 1707233 Ref: Involvement of p53 gene in the allelic deletion of chromosome 17p in human ovarian tumors. PMID: 1776830 Ref: Comparative study of the expression of Rb and p53 genes in human colorectal cancers, colon carcinoma cell lines and synchronized human fibroblasts. PMID: 1784274 Ref: 5-Methylcytosine as an endogenous mutagen in the p53 tumor suppressor gene. PMID: 1844242 Ref: Tumor suppressor genes involved in metastasis of lung and colorectal carcinomas. PMID: 1844253 Ref: [Diagnosis of colorectal cancer from DNA level]. PMID: 1846282 Ref: [Cytomolecular aspects of colorectal carcinoma]. PMID: 1849388 Ref: p53 gene mutations in colorectal tumors from patients with familial polyposis coli. PMID: 1851662 Ref: Genetic analysis of human esophageal tumors from two high incidence geographic areas: frequent p53 base substitutions and absence of ras mutations. PMID: 1855226 Ref: Loss of heterozygosity of p53 gene and p53 protein expression in human colorectal carcinomas. PMID: 1868464 Ref: Detection of p53 gene mutations in human brain tumors by single-strand conformation polymorphism analysis of polymerase chain reaction products. PMID: 1886708 Ref: Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta. PMID: 1886718 Ref: p53 mutations in human cancers. PMID: 1905840 Ref: [Immunochemical evidence of a mutated p53 protein expressed in human colorectal adenocarcinoma]. PMID: 1916131 Ref: [Expression of P53 and heat shock protein in colorectal tumors: an immunohistochemical study]. PMID: 1944162 Ref: Mutation in the TP53 gene in colorectal carcinoma detected by polymerase chain reaction. PMID: 1958596 Ref: p53 in colorectal cancer: clinicopathological correlation and prognostic significance. PMID: 1997114 Ref: Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population. PMID: 1999338 Ref: Chromosomal localization of two human zinc finger protein genes, ZNF24 (KOX17) and ZNF29 (KOX26), to 18q12 and 17p13-p12, respectively. PMID: 2004757 Ref: Loss of heterozygosity suggests multiple genetic alterations in pheochromocytomas and medullary thyroid carcinomas. PMID: 2022740 Ref: Frequent loss of a p53 allele in carcinomas and their precursors in ulcerative colitis. PMID: 2049225 Ref: Reduction to homozygosity involving p53 in esophageal cancers demonstrated by the polymerase chain reaction. PMID: 2052580 |
Ref: Colorectal carcinoma as a genetic phenomenon. PMID: 1294935 Ref: [Genetics and cancers]. PMID: 1303491 Ref: Evolutionary aspects of human cancer. PMID: 1306136 Ref: Mutations of the p53 gene and other genes involving in human colorectal carcinogenesis. PMID: 1306299 Ref: p53 mutations in non-small cell lung cancer in Japan: association between mutations and smoking. PMID: 1310070 Ref: Multistage carcinogenesis in paediatric and adult cancers. PMID: 1314630 Ref: Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients. PMID: 1319835 Ref: Cell and molecular biology of gastrointestinal tract cancer. PMID: 1324739 Ref: Tumor-suppressor genes: cardinal factors in inherited predisposition to human cancers. PMID: 1336726 Ref: Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer. PMID: 1347643 Ref: Characterization of an endogenous RNA transcript with homology to the antisense strand of the human c-myc gene. PMID: 1378845 Ref: Secretion of cell-adhesion-promoting factors, fibronectin, fibronectin fragments and a 53-kDa protein, by human rectal adenocarcinoma cells. PMID: 1385337 Ref: [Immunohistochemical detection of p53 in colorectal cancer and its relationship to prognosis]. PMID: 1435694 Ref: Cellular and molecular mechanisms of hepatocarcinogenesis. PMID: 1439879 Ref: Expression of p53 protein in invasive colorectal carcinomas of different histologic types. PMID: 1451054 Ref: Expression of p53 protein in colorectal cancer and its relationship to short-term prognosis. PMID: 1451055 Ref: Suppressor gene alterations in the colorectal adenoma-carcinoma sequence. PMID: 1469893 Ref: [Significance of p53 gene abnormalities in carcinogenesis of human gastrointestinal tract]. PMID: 1470160 Ref: [Complex characteristics of the alterations of oncogenes HER-2/ERBB-2, HER-1/ERBB-1, HRAS-1, C-MYC and antioncogenes p53, RB1, as well as deletions of loci of chromosome 17 in colon carcinoma]. PMID: 1470178 Ref: Mutations of p53 gene in human colorectal tumor in Japan: molecular epidemiological aspects. PMID: 1488746 Ref: [The analysis of p53 on the way of submucosal invasion in superficial type colorectal cancer]. PMID: 1501374 Ref: Oncogenesis in ovarian cancer. PMID: 1502889 Ref: Molecular genetics of colorectal carcinoma. PMID: 1511369 Ref: DNA polymerase beta mutations in human colorectal cancer. PMID: 1511447 Ref: Genetic alterations in the adenoma--carcinoma sequence. PMID: 1516027 Ref: Current status of adjuvant chemotherapy for colorectal cancer. Can molecular markers play a role in predicting prognosis? PMID: 1516028 Ref: Prognostic significance of p53 overexpression in gastric and colorectal carcinoma. PMID: 1520594 Ref: Molecular genetic alterations as potential prognostic indicators in colorectal carcinoma. PMID: 1540900 Ref: Immunohistochemical study of p53 expression in microwave-fixed, paraffin-embedded sections of colorectal carcinoma and adenoma. PMID: 1546693 Ref: Expression of p53 and 17p allelic loss in colorectal carcinoma. PMID: 1551126 Ref: Allelotype analysis in osteosarcomas: frequent allele loss on 3q, 13q, 17p, and 18q. PMID: 1568211 Ref: Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. PMID: 1584781 Ref: P53 mutations in gastric carcinomas. PMID: 1586599 Ref: Tumor-susceptibility markers. PMID: 1616794 Ref: Growth-inhibition of ht29 cells exposed to N-methylformamide correlates with altered expression of alpha-6/beta-4 integrin. PMID: 21584516 Ref: Genetic abnormalities and expression of p53 in human colon carcinomas. PMID: 21584563 Ref: A comparative immunohistochemical study of p53 and proliferating-cell nuclear antigen expression in microwave-fixed paraffin sections of colorectal tumors. PMID: 21584615 |
Ref: Hot spots mutation analysis of p53 gene in gastrointestinal cancers by amplification of naturally occurring and artificially created restriction sites. PMID: 7691445 Ref: Carcinogenic factors in food with relevance to colon cancer development. PMID: 7694098 Ref: Concordant p53 and DCC alterations and allelic losses on chromosomes 13q and 14q associated with liver metastases of colorectal carcinoma. PMID: 8094072 Ref: [Accumulation of genetic alterations during human tumor progression]. PMID: 8094949 Ref: [Metastasis related genes and malignancy in human esophageal, gastric and colorectal cancers]. PMID: 8094950 Ref: Mutations of the p53 gene in carcinomas of the urinary system. PMID: 8109252 Ref: [Molecular genetics of colorectal cancer and carcinogenesis]. PMID: 8134731 Ref: Effect of sodium butyrate on the expression of retinoblastoma (RB1) and P53 gene and phosphorylation of retinoblastoma protein in human colon tumor cell line HT29. PMID: 8220069 Ref: Models of neoplasia and their diagnostic implications: a historical perspective. PMID: 8222248 Ref: Hepatitis B and alterations of the p53 tumor suppressor gene in hepatocellular carcinoma. PMID: 8238731 Ref: WAF1, a potential mediator of p53 tumor suppression. PMID: 8242752 Ref: Genetic events responsible for colorectal tumorigenesis: achievements and challenges. PMID: 8249174 Ref: Immunohistochemical expression of mutant p53 oncogene in transitional mucosa adjacent to human colon cancer. PMID: 8261691 Ref: Immunohistochemical detection of RAS, JUN, FOS, and p53 oncoprotein expression in human colorectal adenomas and carcinomas. PMID: 8264230 Ref: p53 mutations in colorectal cancers in the patients of Metropolitan New York. PMID: 8267380 Ref: Functional interaction of wild-type and mutant p53 transfected into human tumor cell lines carrying activated ras genes. PMID: 8274455 Ref: Mutations of the p53 tumor suppressor gene and the ras gene family in intrahepatic cholangiocellular carcinomas in Japan and Thailand. PMID: 8280380 Ref: Biological consequences of the genetic changes which occur during human colorectal carcinogenesis. PMID: 8318691 Ref: p53 is mutated in a subset of advanced-stage prostate cancers. PMID: 8324747 Ref: Efficient screening of p53 mutations by denaturing gradient gel electrophoresis in colorectal tumors. PMID: 8336944 Ref: p53 immunoreaction in endoscopic biopsy specimens of colorectal cancer, and its prognostic significance. PMID: 8347496 Ref: In vitro models of human colorectal cancer. PMID: 8348534 Ref: Sodium butyrate causes an increase in the block to transcriptional elongation in the c-myc gene in SW837 rectal carcinoma cells. PMID: 8376401 Ref: Does a genotoxic carcinogen contribute to human breast cancer? The value of mutational spectra in unravelling the aetiology of cancer. PMID: 8377645 Ref: Frequently elevated content of immunochemically defined wild-type p53 protein in colorectal adenomas. PMID: 8378077 Ref: Characterization of the DiFi rectal carcinoma cell line derived from a familial adenomatous polyposis patient. PMID: 8385096 Ref: p53 mutation in gastric cancer: a genetic model for carcinogenesis is common to gastric and colorectal cancer. PMID: 8392033 Ref: Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: implications for the possible role of dietary fibre in the prevention of large-bowel cancer. PMID: 8397167 Ref: Exclusion of constitutional p53 mutations as a cause of genetic susceptibility to colorectal cancer. PMID: 8398698 Ref: Neuroblastoma: the result of multistep transformation? PMID: 8401251 Ref: Genetic changes and histopathological grades in human hepatocellular carcinomas. PMID: 8407553 Ref: Molecular events including p53 and k-ras alterations in the in vitro progression of a human colorectal adenoma cell line to an adenocarcinoma. PMID: 8414507 Ref: Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer. PMID: 8419262 Ref: Frequent loss of heterozygosity on chromosome 14 occurs in advanced colorectal carcinomas. PMID: 8437850 Ref: Turcot's syndrome of glioma and polyposis occurs in the absence of germ line mutations of exons 5 to 9 of the p53 gene. PMID: 8439970 Ref: Molecular mechanism of stomach carcinogenesis. PMID: 8440743 Ref: [Analysis of molecular mechanism in colorectal tumorigenesis]. PMID: 8458595 Ref: Tumour suppressor genes and colorectal neoplasia. PMID: 8471756 Ref: Clonal ordering of 17p and 5q allelic losses in Barrett dysplasia and adenocarcinoma. PMID: 8475062 Ref: Stabilised p53 facilitates aneuploid clonal divergence in colorectal cancer. PMID: 8479757 Ref: p53 protein immunostaining in routinely processed paraffin-embedded sections. PMID: 8483890 Ref: Clues to the pathogenesis of familial colorectal cancer. PMID: 8484121 Ref: [Analysis of p53 expression and DNA ploidy pattern in colorectal cancer]. PMID: 8489286 Ref: Expression of p53 in colorectal cancer and dysplasia complicating ulcerative colitis. PMID: 8495305 Ref: p53 point mutations in dysplastic and cancerous ulcerative colitis lesions. PMID: 8500720 Ref: The biology of colorectal cancer. Implications for pretreatment and follow-up management. PMID: 8508377 Ref: Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinomas. PMID: 8515492 Ref: P53 expression is associated with a high-degree of tumor DNA aneuploidy and incidence of p53 gene mutation, and is localized to the aneuploid component in colorectal carcinomas. PMID: 21573365 Ref: Mutations in the p53 suppressor gene do not correlate with C-k-ras oncogene mutations in colorectal-cancer. PMID: 21573526 Ref: Mutation and expression of the p53 tumor suppressor gene in tumor samples and cancer cell-lines - comparison of nonisotopic direct DNA-sequencing, immunoblotting and immunohistochemistry. PMID: 21573561 |
Ref: CD44 expression in colorectal adenomas is an early event occurring prior to K-ras and p53 gene mutation. PMID: 7513984 Ref: Tumor angiogenesis, the p53 antigen, and cervical metastasis in squamous carcinoma of the tongue. PMID: 7524005 Ref: Risk factors related to liver metastasis in colorectal carcinoma: a multivariate analysis of clinicopathologic and immunohistochemical variables. PMID: 7531682 Ref: Esophageal cancer. PMID: 7533069 Ref: Positive relationship between expression of CD44 and hepatic metastases in colorectal cancer. PMID: 7537507 Ref: [Etiology of colorectal cancer]. PMID: 7557283 Ref: Gene alterations in intestinal metaplasia and gastric cancer. PMID: 7735945 Ref: A detailed study of p53 mutations in colorectal cancer in Singapore. PMID: 7741489 Ref: Advances in the genetics and molecular biology of colorectal tumors. PMID: 7803543 Ref: Tumor suppressor genes and their roles in breast cancer. PMID: 7819583 Ref: Quantitation and morphometric analysis of tumors by image analysis. PMID: 7823583 Ref: Mutations of Ki-ras and p53 genes in colorectal cancer and their prognostic significance. PMID: 7828987 Ref: Variables related to risk of recurrence in rectal cancer without lymph node metastasis. PMID: 7834447 Ref: [p53: an important or most overvalued tumor gene?]. PMID: 7840829 Ref: [Effect of overexpression of P53 protein in colorectal carcinoma on short-term prognosis]. PMID: 7848689 Ref: Characterization of p53 gene mutations in colorectal carcinomas from an Asian population. PMID: 7872723 Ref: [Genes, heredity and colorectal cancer]. PMID: 7878358 Ref: Molecular genetics for clinical management of colorectal carcinoma. 17p, 18q, and 22q loss of heterozygosity and decreased DCC expression are correlated with the metastatic potential. PMID: 7906606 Ref: Overexpression of p53 protein and proliferative activity in colorectal adenoma. PMID: 7910956 Ref: Expression of EGF, EGF-receptor, p53, v-erb B and ras p21 in colorectal neoplasms by immunostaining paraffin-embedded tissues. PMID: 7912978 Ref: p53 and behaviour of colorectal cancer. PMID: 7913159 Ref: Prognostic factors of colorectal cancer: K-ras mutation, overexpression of the p53 protein, and cell proliferative activity. PMID: 7914949 Ref: Tumor spectrum analysis in p53-mutant mice. PMID: 7922305 Ref: p53 nuclear overexpression: an independent predictor of survival in lymph node--positive colorectal cancer patients. PMID: 7931472 Ref: Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction. PMID: 7947085 Ref: Computer program for the analysis of mutational spectra: application to p53 mutations. PMID: 7955067 Ref: Comparative clinicopathological and immunohistochemical study of ras and p53 in flat and polypoid type colorectal tumours. PMID: 7959233 Ref: The capacity for growth stimulation by TGF beta 1 seen only in advanced colon cancers cannot be ascribed to mutations in APC, DCC, p53 or ras. PMID: 7970729 Ref: [A case report of primary triple cancers in the thyroid, stomach and rectum with evidence of variable oncoprotein expressions]. PMID: 8001692 Ref: Methods in pathology. p53 expression in formalin-fixed, paraffin-embedded archival specimens of intrahepatic cholangiocarcinoma: retrieval of p53 antigenicity by microwave oven heating of tissue sections. PMID: 8008749 Ref: Cytokines, growth factors and the loss of negative growth controls in the progression of human cutaneous malignant melanoma. PMID: 8011699 Ref: Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. PMID: 8030745 Ref: Genetic diagnosis identifies occult lymph node metastases undetectable by the histopathological method. PMID: 8033106 Ref: Molecular genetic profiles of colitis-associated neoplasms. PMID: 8039618 Ref: A comparison of Southern blot and polymerase chain reaction as techniques to identify loss of DNA heterozygosity in colorectal cancer. PMID: 8048895 Ref: [Expression of tumor suppressor gene p53 and Rb in patients with epidermoid carcinoma of the head and neck]. PMID: 8050915 Ref: Overexpression of p53 and long-term survival in colon carcinoma. PMID: 8054278 Ref: Correlation of p53 with the clinicopathologic features and prognosis of colorectal adenocarcinoma. PMID: 8054784 Ref: Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers. PMID: 8056443 Ref: A study of stabilisation of p53 protein versus point mutation in colorectal carcinoma. PMID: 8058340 Ref: A frequent alteration of p53 gene in carcinoma in adenoma of colon. PMID: 8062281 Ref: Extended lymphadenectomy and the quality of life in rectal cancer patients. PMID: 8063550 Ref: [A case of a juvenile rectal cancer with point mutation of tumor suppressor p53 gene manifesting myelopathy as an initial symptom]. PMID: 8065056 Ref: Immunohistochemical analysis of p53 overexpression in human colonic tumors. PMID: 8076381 Ref: APC and p53 mutations in de novo colorectal adenocarcinomas. PMID: 8081386 Ref: p53 mutations in flat- and polypoid-type colorectal tumors detected by temperature-gradient gel electrophoresis. PMID: 8082516 Ref: DNA alterations in cells from hereditary non-polyposis colorectal cancer patients. PMID: 8108146 Ref: [Genetic alterations of human colorectal cancer]. PMID: 8109990 Ref: Immunohistochemical study of p53 in gastric carcinoma. PMID: 8116572 Ref: p53 mutations in human adrenocortical neoplasms: immunohistochemical and molecular studies. PMID: 8126158 Ref: Cytoplasmic accumulation of p53 protein: an independent prognostic indicator in colorectal adenocarcinomas. PMID: 8158699 Ref: K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis. PMID: 8160776 Ref: Apoptosis induced by inhibition of intercellular contact. PMID: 8163556 Ref: Mapping of DNA alkylation sites induced by adozelesin and bizelesin in human cells by ligation-mediated polymerase chain reaction. PMID: 8180230 Ref: p53 mutations in gastric and colorectal cancers in Texas Hispanics versus Anglos. PMID: 8180781 Ref: Frequent alterations of the tumor suppressor genes p53 and DCC in human pancreatic carcinoma. PMID: 8194712 Ref: Prognostic significance of the loss of heterozygosity of Nm23-H1 and p53 genes in human colorectal carcinomas. PMID: 8199988 Ref: Relationship among p53, stage, and prognosis of large bowel cancer. PMID: 8200229 Ref: The relationship between aneuploidy and p53 overexpression during genesis of colorectal adenocarcinoma. PMID: 8205349 Ref: Neurofibromatosis type I and malignancy: review of 32 pediatric cases treated at a single institution. PMID: 8259105 Ref: Alterations of (CA)n DNA repeats and tumor suppressor genes in human gastric cancer. PMID: 8261459 Ref: High frequency of allelic deletion on chromosome 17p in advanced colorectal cancer. PMID: 8275434 Ref: Association of p53 mutations with short survival in colorectal cancer. PMID: 8276207 Ref: Allelic losses associated with the metastatic potential of colorectal-carcinoma. PMID: 21559585 Ref: Expression of cripto-1 in human colorectal adenomas and carcinomas is related to the degree of dysplasia. PMID: 21559596 Ref: Tumor-suppressor genes in colorectal carcinomas - p53 inactivation is highly associated with allelic loss of chromosome 5q. PMID: 21559610 Ref: Immunohistochemical expression of p53 paraffin sections from colon-cancer specimens - comparison between 2 new monoclonal-antibodies. PMID: 21607363 |
Ref: Induction of Fas-mediated apoptosis in p53-transfected human colon carcinoma cells. PMID: 7478511 Ref: Interaction between murine germline mutations in p53 and APC predisposes to pancreatic neoplasia but not to increased intestinal malignancy. PMID: 7478622 Ref: Contribution of molecular oncology in the detection of colorectal carcinomas. PMID: 7491839 Ref: Biologic characterization of hereditary non-polyposis colorectal cancer. Nuclear ploidy, AgNOR count, microvessel distribution, oncogene expression, and grade-related parameters. PMID: 7532909 Ref: Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis. PMID: 7534253 Ref: The genetics of breast and ovarian cancer. PMID: 7547224 Ref: Correlation of p53 protein expression with apoptotic incidence in colorectal neoplasia. PMID: 7551342 Ref: Absence of p53 gene mutations in rat colon carcinomas induced by azoxymethane. PMID: 7553609 Ref: Are CD44 variant isoforms involved in human tumour progression? PMID: 7553660 Ref: Allelic loss of the p53 gene in colorectal cancer. PMID: 7574422 Ref: Prognostic significance of p53 and c-erbB-2 immunohistochemical evaluation in colorectal adenocarcinoma. PMID: 7579815 Ref: p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. PMID: 7585125 Ref: Microsatellite instability in colorectal adenocarcinoma cell lines that have full-length adenomatous polyposis coli protein. PMID: 7585508 Ref: p53 point mutation and survival in colorectal cancer patients. PMID: 7585578 Ref: p53 nuclear overexpression may not be an independent prognostic marker in early colorectal cancer. PMID: 7587760 Ref: Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. PMID: 7591958 Ref: Somatic mutations of the adenomatous polyposis coli gene in gastroduodenal tumors from patients with familial adenomatous polyposis. PMID: 7606737 Ref: [Development and expression of p53 in superficial early colorectal carcinoma]. PMID: 7609314 Ref: Assessment of dysplasia, mucosal mucins, p53 protein expression, and DNA content in ulcerative colitis patients with colectomy and ileorectal anastomosis. PMID: 7610353 Ref: [An immunohistochemical study of the relationship between p53 expression and the DNA ploidy pattern using image cytometry in colorectal carcinoma]. PMID: 7611775 Ref: [Flow cytometric measurement of p53 protein and DNA content in colorectal carcinomas with liver metastasis]. PMID: 7611776 Ref: [Immunohistochemical distribution of p53 and Ki-67 in 2 cases of colorectal carcinoma occurring in ulcerative colitis]. PMID: 7611778 Ref: P53 germ line haplotypes associated with increased risk for colorectal cancer. PMID: 7614678 Ref: Cell cycle dependent effects of u.v.-radiation on p53 expression and retinoblastoma protein phosphorylation. PMID: 7624123 Ref: Microinjection of monoclonal antibody PAb421 into human SW480 colorectal carcinoma cells restores the transcription activation function to mutant p53. PMID: 7627952 Ref: Base excision repair of U:G mismatches at a mutational hotspot in the p53 gene is more efficient than base excision repair of T:G mismatches in extracts of human colon tumors. PMID: 7641186 Ref: Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression. PMID: 7651727 Ref: Mutations of the tumour suppressor gene p53 in colorectal and hepatocellular carcinomas. PMID: 7653961 Ref: Review article: manipulation of cell death--the development of novel strategies for the treatment of gastrointestinal disease. PMID: 7654884 Ref: p53 gene mutations in early colorectal carcinoma. De novo vs. adenoma-carcinoma sequence. PMID: 7665248 Ref: Using biopsy materials to detect mutations in gastrointestinal tumors. PMID: 7665812 Ref: Antibodies against p53 are associated with poor prognosis of colorectal cancer. PMID: 7669574 Ref: p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells. PMID: 7671255 Ref: The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma. PMID: 7674088 Ref: p53 gene mutations, p53 protein accumulation and compartmentalization in colorectal adenocarcinoma. PMID: 7677190 Ref: Association of p53 gene and protein alterations with metastases in colorectal cancer. PMID: 7694948 Ref: Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage. PMID: 7700629 Ref: Mechanism of synergy of levamisole and fluorouracil: induction of human leukocyte antigen class I in a colorectal cancer cell line. PMID: 7707435 Ref: Family history of cancer, body weight, and p53 nuclear overexpression in Duke's C colorectal cancer. PMID: 7710960 Ref: Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline. PMID: 7712469 Ref: Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers. PMID: 7731703 Ref: Colorectal carcinomas show frequent allelic loss on the long arm of chromosome 17 with evidence for a specific target region. PMID: 7734302 Ref: 17q allele loss is associated with lymph node metastasis in locally aggressive human colorectal cancer. PMID: 7745498 Ref: Genetic diagnosis of lymph-node metastasis in colorectal cancer. PMID: 7746054 Ref: bcl-2 oncoprotein in colorectal hyperplastic polyps, adenomas, and adenocarcinomas. PMID: 7750937 Ref: Levels of p53 antigen in the plasma of patients with adenomas and carcinomas of the colon. PMID: 7767914 Ref: Evaluation of p53 protein expression as a marker for long-term prognosis in colorectal carcinoma. PMID: 7779721 Ref: Gamma-radiation-induced apoptosis in human colorectal adenoma and carcinoma cell lines can occur in the absence of wild type p53. PMID: 7784088 Ref: Ras oncogene and p53 gene hotspot mutations in colorectal cancers. PMID: 7787154 Ref: Somatic mutations detected by mini- and microsatellite DNA markers reveal clonal intratumor heterogeneity in gastrointestinal cancers. PMID: 7796414 Ref: Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon. PMID: 7835585 Ref: Mutation of the p53 gene precedes aneuploid clonal divergence in colorectal carcinoma. PMID: 7841032 Ref: Immunohistochemical analysis of p53 in colorectal cancer regarding clinicopathological correlation and prognostic significance. PMID: 7844983 Ref: Polymorphisms and probable lack of mutation in the WAF1-CIP1 gene in colorectal cancer. PMID: 7845685 Ref: The genetic basis of colorectal cancer--clinical implications. PMID: 7851569 Ref: Low frequency and late occurrence of p53 and dcc aberrations in colorectal tumours. PMID: 7860623 Ref: Genetic alterations in human gastrointestinal cancers. The application to molecular diagnosis. PMID: 7889467 Ref: Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression? PMID: 7889486 Ref: Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect. PMID: 7890601 Ref: The production and characterization of murine monoclonal antibodies to human Gadd45 raised against a recombinant protein. PMID: 8522347 Ref: Molecular markers in chemoprevention of colon cancer. Inhibition of expression of ras-p21 and p53 by sulindac during azoxymethane-induced colon carcinogenesis. PMID: 8526349 Ref: An immunohistochemical study of the expression of p53 protein in colon cancer. PMID: 8527043 Ref: p53 expression in ulcerative colitis: a longitudinal study. PMID: 8537051 Ref: Ornithine decarboxylase and tyrosine kinase activity in juvenile polyps of childhood. PMID: 8559612 Ref: Relation between stage, grade, proliferation, and expression of p53 and CD44 in adenomas and carcinomas of the colorectum. PMID: 8567994 Ref: Nutritional intervention to prevent hereditary cancer. PMID: 8573452 Ref: [Stimulation of differentiation of LIM 1215 large intestinal tumor cells during expression of the p53 exogenous antioncogene or the activated ras oncogene]. PMID: 8579493 Ref: Identification of mutations by RNA conformational polymorphism "bar code" analysis. PMID: 8595893 Ref: 1995 Deichmann Lecture--p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology and cancer risk assessment. PMID: 8597035 Ref: Genetic and environmental factors in the etiology of human brain tumors. PMID: 8597115 Ref: Molecular biology of colon polyps and colon cancer. PMID: 8607008 Ref: Multistep carcinogenesis in colorectal cancers. PMID: 8629105 Ref: Prediction of recurrence in B-C stages of colorectal cancer by p53 nuclear overexpression in comparison with standard pathological features. PMID: 8631411 Ref: Clonal analysis of colorectal tumors using K-ras and p53 gene mutations as markers. PMID: 8634782 Ref: Heterogeneity in proliferation markers in colorectal cancer. PMID: 8669859 Ref: Genetic and cellular changes in colorectal cancer: proposed targets of chemopreventive agents. PMID: 8672984 Ref: [p53 gene point mutation in human colorectal carcinoma]. PMID: 8697967 Ref: [Detection of the expression of P21, P53, P185 proteins and the mutation of ras, p53 genes in colorectal adenoma and carcinoma]. PMID: 8732090 Ref: p53, myc, APC, hMSH2, ras, etc. in colorectal cancer - a never ending story! PMID: 8750144 Ref: Evidence for a mutual regulation of p53 and c-myc expression in human colorectal cancer metastases. PMID: 8750149 Ref: p53 protein expression in colorectal adenomas: an immunohistochemical study using an antigen retrieval system. PMID: 8838331 Ref: [Clinico-pathological features and biological characterization of mucoid colorectal carcinoma]. PMID: 8927422 Ref: An immunohistochemical study of P53 protein on colorectal carcinomas. PMID: 9455363 Ref: Prognostic value of bcl-2 oncoprotein expression in stage II colon carcinoma. PMID: 9815900 Ref: Absence of p53 autoantibodies in sera from glioma patients. PMID: 9816045 Ref: Immunohistochemically detectable p53 and mdm-2 oncoprotein expression in colorectal carcinoma: prognostic significance. PMID: 16695968 Ref: Prevalence of p53 overexpression or mutations, but not k-ras mutations, in recurrent patients affected by colorectal-carcinoma. PMID: 21552967 Ref: Alterations of p53 and k-ras genes in human colorectal-cancer with ulcerative-colitis. PMID: 21556601 Ref: Influence of retrovirally transduced human tumor-necrosis-factor-alpha on the expression of C-myc, k-ras, C-jun, p53, tgf-alpha, and cea in human colon-carcinoma cell-lines. PMID: 21556635 Ref: The expression of p53 tumor-suppressor protein during progression of gastric and colorectal carcinomas. PMID: 21556675 Ref: Isolation of p53 protein from the serum of colon-cancer and noncancer patients. PMID: 21597798 Ref: Colon carcinogenesis in inflammatory bowel disease. PMID: 23282306 |
Ref: Induction of apoptosis by c-Fos protein. PMID: 8524298 Ref: Contributions of molecular genetics to the clinical management of colorectal cancer. PMID: 8554121 Ref: Prognostic value of TP53 and K-ras-2 mutational analysis in stage III carcinoma of the colon. PMID: 8554149 Ref: p53 functional loss in a colon cancer cell line with two missense mutations (218leu and 248trp) on separate alleles. PMID: 8556707 Ref: p53 Protein overexpression in colorectal tumors from patients with familial adenomatous polyposis: is it an early or late event? PMID: 8561108 Ref: Apoptosis occurs more frequently in metastatic foci than in primary lesions of human colorectal carcinomas: analysis by terminal-deoxynucleotidyl-transferase-mediated dUTP-biotin nick end labeling. PMID: 8567113 Ref: Fine mapping of colon tumor susceptibility (Scc) genes in the mouse, different from the genes known to be somatically mutated in colon cancer. PMID: 8577718 Ref: Apoptosis of colon cancer: comparison with Ki-67 proliferative activity and expression of p53. PMID: 8601565 Ref: Loss of heterozygosity of multiple tumor suppressor genes in human gastric cancers by polymerase chain reaction. PMID: 8606493 Ref: p53 gene therapy in vivo of herpatocellular and liver metastatic colorectal cancer. PMID: 8607033 Ref: Allelic loss of chromosome 17p, mutation of the p53 gene, and microsatellite instability in right- and left-sided colorectal cancer. PMID: 8608563 Ref: Mutations of the p53 gene in the stool of patients with resectable colorectal cancer. PMID: 8608566 Ref: Apoptotic cell death and its relationship to carcinogenesis in colorectal carcinoma. PMID: 8608567 Ref: Detection of DCC and Ki-ras gene alterations in colorectal carcinoma tissue as prognostic markers for liver metastatic recurrence. PMID: 8608570 Ref: Efficacy of an angiogenesis inhibitor, TNP-470, in xenotransplanted human colorectal cancer with high metastatic potential. PMID: 8608571 Ref: p53 protein overexpression and response to biomodulated 5-fluorouracil chemotherapy in patients with advanced colorectal cancer. PMID: 8608838 Ref: APC gene mutations in human prostate cancer. PMID: 8609698 Ref: Evidence of reciprocity of bcl-2 and p53 expression in human colorectal adenomas and carcinomas. PMID: 8611422 Ref: The relationship between smoking exposure and p53 overexpression in colorectal cancer. PMID: 8611424 Ref: Suppression of cellular proliferation using p53 DNA recognition site-related oligonucleotides. PMID: 8615376 Ref: DNA lesion-recognizing proteins and the p53 connection. PMID: 8615613 Ref: DNA-dependent protein kinase inhibitor (OK-1035) suppresses p21 expression in HCT116 cells containing wild-type p53 induced by adriamycin. PMID: 8619835 Ref: Mutation of p53 tumor suppressor gene in flat neoplastic lesions of the colorectal mucosa. PMID: 8620779 Ref: p53 expression in colorectal cancer: relation to tumor type, DNA ploidy pattern and short-term survival. PMID: 8623770 Ref: Clinical and pathological significance of microsatellite instability in sporadic endometrial carcinoma. PMID: 8623934 Ref: Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas. Aspects of carcinogenesis and prognostic significance. PMID: 8625232 Ref: Clinical implications of microsatellite instability in colorectal cancers. PMID: 8625233 Ref: Repair Defect in p21 WAF1/CIP1 -/- human cancer cells. PMID: 8625293 Ref: Mechanisms for the involvement of DNA methylation in colon carcinogenesis. PMID: 8625314 Ref: Analysis of a germ line polymorphism of the p53 gene in lung cancer patients; discrete results with smoking history. PMID: 8625447 Ref: Histopathological studies of superficial-type early colorectal carcinoma. PMID: 8630938 Ref: An abnormality in the p53 pathway following gamma-irradiation in many wild-type p53 human melanoma lines. PMID: 8631022 Ref: Different p53 mutations produce distinct effects on the ability of colon carcinoma cells to become blocked at the G1/S boundary after irradiation. PMID: 8632910 Ref: The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: alterations in tumor suppressor and cell cycle-regulatory proteins. PMID: 8632912 Ref: K-ras mutation in a tubular adenoma originating at an ileostomy in a familial adenomatous polyposis patient. PMID: 8633516 Ref: Frequency of Ki-ras mutations and DNA alkylation in colorectal tissue from individuals living in Manchester. PMID: 8634090 Ref: Triple primary malignant neoplasms including a malignant brain tumor: report of two cases and review of the literature. PMID: 8638217 Ref: Genetic heterogeneity and unmapped genes for colorectal cancer. PMID: 8640829 Ref: The p53 gene is a potent determinant of chemosensitivity and radiosensitivity in gastric and colorectal cancers. PMID: 8642047 Ref: A novel method for gene analysis of colorectal carcinomas using a crypt isolation technique. PMID: 8642788 Ref: A pilot study on risk factors and p53 gene expression in colorectal cancer. PMID: 8645592 Ref: Synchronous colon carcinomas: molecular-genetic evidence for multicentricity. PMID: 8646513 Ref: Inheritance of abnormal expression of SOS-like response in xeroderma pigmentosum and hereditary cancer-prone syndromes. PMID: 8653707 Ref: UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53. PMID: 8667426 Ref: Acute and delayed apoptosis induced by thymidine deprivation correlates with expression of p53 and p53-regulated genes in colon carcinoma cells. PMID: 8668331 Ref: Expression of protooncogene-encoded mRNA by colonic epithelial cells in inflammatory bowel disease. PMID: 8674385 Ref: [Advances in the treatment of colorectal cancer]. PMID: 8678508 Ref: [The results of p53 immunostaining in colorectal adenomas, early cancers, advanced cancers and their hepatic metastasis]. PMID: 8678561 Ref: [Analysis of genetic changes in progression of colorectal cancer]. PMID: 8678562 Ref: p53 mutations as a possible predictor of response to chemotherapy in metastatic colorectal carcinomas. PMID: 8682586 Ref: Immunohistological p53 staining is of limited value in the staging and prognostic prediction of colorectal cancer. PMID: 8687158 Ref: [Prognostic factors of colon cancer from a molecular biology standpoint]. PMID: 8687233 Ref: Clinical and pathological associations with p53 tumour-suppressor gene mutations and expression of p21WAF1/Cip1 in colorectal carcinoma. PMID: 8688317 Ref: Prognostic significance of p53 overexpression and mutation in colorectal adenocarcinomas. PMID: 8688324 Ref: Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. PMID: 8690195 Ref: Bcl-2 expression and allelic loss of the p53 gene in gastric carcinomas. PMID: 8690754 Ref: Early expression of bcl-2 protein in the adenoma-carcinoma sequence of colorectal neoplasia. PMID: 8691332 Ref: p53 antisense oligonucleotide inhibits growth of human colon tumor and normal cell lines. PMID: 8698624 Ref: Decorin-induced growth suppression is associated with up-regulation of p21, an inhibitor of cyclin-dependent kinases. PMID: 8702560 Ref: [Tumor suppressor gene p53. Theoretical principles and their significance for pathology]. PMID: 8710788 Ref: Familial and nutritional risk factors for p53 overexpression in colorectal cancer. PMID: 8722220 Ref: Genomania of p53 protein in gastric cancer. PMID: 8724251 Ref: Immunohistochemical analysis of p53 and ras p21 expression in colorectal adenomas and early carcinomas. PMID: 8727942 Ref: Bcl-2, p53, CD44, and CD44v6 isoform expression in neuroendocrine tumors of the lung. PMID: 8733762 Ref: Prognostic significance of p53 expression, chromosome 17 copy number, and DNA ploidy in non-metastasized colorectal carcinomas (stages IB and II). PMID: 8734346 Ref: Genetic pathways in colorectal cancer. PMID: 8735714 Ref: Genetic determinants of p53-induced apoptosis and growth arrest. PMID: 8756351 Ref: An immunohistochemical study of the simultaneous expression of bcl-2 and p53 oncoproteins in epithelial tumors of the colon and rectum. PMID: 8757470 Ref: Inter-observer variation of p53 immunohistochemistry--an assessment of a practical problem and comparison with other studies. PMID: 8757686 Ref: Fluoropyrimidine-mediated radiosensitization depends on cyclin E-dependent kinase activation. PMID: 8764107 Ref: Numerical chromosome alterations in colorectal carcinomas detected by fluorescence in situ hybridization. Relationship to 17p and 18q allelic losses. PMID: 8764933 Ref: [A comparative study on the prognostic value of the nuclear expression of protein p53 vis-a-vis histopathology in colorectal cancer]. PMID: 8767868 Ref: Amplification of the parathyroid hormone-related peptide gene in a colonic carcinoma. PMID: 8768840 Ref: K-ras and p53 mutations in human colorectal aberrant crypt foci. PMID: 8778329 Ref: Correlation of intratumoral microvessel density and p53 protein overexpression in human colorectal adenocarcinoma. PMID: 8778572 Ref: p53 and prognosis in colorectal cancer. PMID: 8779527 Ref: Molecular changes of colorectal cancer in Singapore. PMID: 8779542 Ref: A novel deletion within exon 6 of TP53 in a family with Li-Fraumeni-like syndrome, and LOH in a benign lesion from a mutation carrier. PMID: 8780740 Ref: Reduced messenger RNA expression level of p21 CIP1 in human colorectal carcinoma tissues and its association with p53 gene mutation. PMID: 8797864 Ref: Double cancer in a 74-year-old woman: a case report with genetic findings. PMID: 8804161 Ref: Correlations between S and G2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells. PMID: 8813137 Ref: Immunohistochemical detection of p21waf1/cip1/sdi1 and p53 proteins in formalin-fixed, paraffin-embedded tissue sections of colorectal carcinoma. PMID: 8816885 Ref: Carcinoma of the rectum. Possible cellular predictors of metastatic potential and response to radiation therapy. PMID: 8831521 Ref: p21 (WAF1/CIP1) expression is induced in newly nondividing cells in diverse epithelia and during differentiation of the Caco-2 intestinal cell line. PMID: 8831553 Ref: Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53. PMID: 8831555 Ref: Microsatellite instability-associated mutations associate preferentially with the intestinal type of primary gastric carcinomas in a high-risk population. PMID: 8840981 Ref: DNA damage and p53 induction do not cause ZD1694-induced cell cycle arrest in human colon carcinoma cells. PMID: 8840989 Ref: Modulation of colon tumor oncogene expression by cancer patient-derived lipids. PMID: 8841466 Ref: Clinico-pathological correlation and prognostic significance of nuclear p53 protein in colorectal cancer. Colorectal Cancer Study Group of the University and Health Care District of Modena. PMID: 8842835 Ref: Expression of cyclin E in colorectal adenomas and adenocarcinomas: correlation with expression of Ki-67 antigen and p53 protein. PMID: 8865848 Ref: Clinico-pathological features and p53 expression in left-sided sporadic colorectal cancers with and without microsatellite instability. PMID: 8869282 Ref: p53 nuclear protein overexpression in colorectal cancer: a dominant predictor of survival in patients with advanced hepatic metastases. PMID: 8874329 Ref: Clinical practice guidelines for the use of tumor markers in breast and colorectal cancer. Adopted on May 17, 1996 by the American Society of Clinical Oncology. PMID: 8874347 Ref: p53 gene mutation is not directly related to tumoricidal effects of preoperative radiochemohyperthermia therapy for rectal cancers. PMID: 8888799 Ref: Colorectal adenocarcinoma as a second malignant neoplasm following Wilms' tumor and rhabdomyosarcoma. PMID: 8888817 Ref: The molecular biology of esophageal carcinoma. PMID: 8893331 Ref: Radio-induced modulation of transforming growth factor beta1 sensitivity in a p53 wild-type human colorectal-cancer cell line. PMID: 8895552 Ref: A very large villous adenoma with an adjacent cancer of the rectum: an informative case for testing the proposed molecular basis of colorectal tumorigenesis. PMID: 8895682 Ref: Genetic aspects of colorectal cancer: the surgeon's view. PMID: 8898451 Ref: MDR1 expression correlates with mutant p53 expression in colorectal cancer metastases. PMID: 8898977 Ref: The flow cytometric analysis of total p53 protein content and proliferation indices in colorectal cancer, in relation to clinical outcome. PMID: 8903495 Ref: NM-23 H1 immunohistochemistry is not useful as predictor of metastatic potential of colorectal cancer. PMID: 8912537 Ref: Higher expression of oncoproteins c-myc, c-erb B-2/neu, PCNA, and p53 in metastasizing colorectal cancer than in nonmetastasizing tumors. PMID: 8915491 Ref: Photodynamic anticancer agent merocyanine540 inhibits cell growth by apoptosis. PMID: 8917386 Ref: Detection of circulating anti-p53 antibodies in patients with colorectal carcinoma and the antibody's relation to clinical factors. PMID: 8918437 Ref: Malignant rhabdoid tumor of the colon. Report of a case with molecular analysis. PMID: 8918447 Ref: [Recent progress of molecular oncology and its contribution to clinical gastroenterology]. PMID: 8920648 Ref: [Genetic steps in colorectal cancer]. PMID: 8920676 Ref: p53 tumor suppressor gene status and the degree of genomic instability in sporadic colorectal cancers. PMID: 8931611 Ref: Differential GADD45, p21CIP1/WAF1, MCL-1 and topoisomerase II gene induction and secondary DNA fragmentation after camptothecin-induced DNA damage in two mutant p53 human colon cancer cell lines. PMID: 8938795 Ref: Stress responses to DNA damaging agents in the human colon carcinoma cell line, RKO. PMID: 8950345 Ref: Antisense GADD45 expression results in decreased DNA repair and sensitizes cells to u.v.-irradiation or cisplatin. PMID: 8950993 Ref: Characterisation and clinicopathological correlates of serum anti-p53 antibodies in breast and colon cancer. PMID: 8954174 Ref: Restoration of the transcription activation function to mutant p53 in human cancer cells. PMID: 8957091 Ref: Expression of bcl-2 and p53 in de novo and ex-adenoma colon carcinoma: a comparative immunohistochemical study. PMID: 8958802 Ref: The cellular and molecular pathogenesis of colorectal cancer. PMID: 8960890 Ref: Infection of human papillomavirus (HPV) and p53 over-expression in human female genital tract carcinoma. PMID: 8961706 Ref: Flow cytometric examination of p53 protein in primary tumors and metastases to the liver and lymph nodes of colorectal cancer. PMID: 8969671 Ref: Molecular pathogenesis of adenoma and differentiated adenocarcinoma of the stomach. PMID: 8970192 Ref: Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice. PMID: 8971180 Ref: p53 and PCNA expression in advanced colorectal cancer: response to chemotherapy and long-term prognosis. PMID: 8980242 Ref: Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide. PMID: 8986786 Ref: Induction of HSP70 gene expression by modulation of Ca(+2) ion and cellular p53 protein by curcumin in colorectal carcinoma cells. PMID: 8989916 Ref: Expression of wild-type p53 stimulates an increase in both Bax and Bcl-xL protein content in HT29 cells. PMID: 9000137 Ref: Inverse correlation between RER+ status and p53 mutation in colorectal cancer cell lines. PMID: 9000147 Ref: Prognostic significance of p53 abnormalities in colorectal carcinoma detected by PCR-SSCP and immunohistochemical analysis. PMID: 9014855 Ref: Allelotype of adenoma and differentiated adenocarcinoma of the stomach. PMID: 9014856 Ref: DNA alterations in sporadic colorectal tumors do not correlate with tumor staging diagnosed by the TNM system. PMID: 9020916 Ref: Ulcerative colitis with overexpression of p53 preceding overt histological abnormalities of the epithelium. PMID: 9027653 Ref: In vivo adenovirus-mediated p53 tumor suppressor gene therapy for colorectal cancer. PMID: 9042200 Ref: Immunohistochemical p53 overexpression correlated to c-erbB-2 and cathepsin D proteins in colorectal cancer. PMID: 9042263 Ref: Comparative study of the role of serum levels of p53 antigen and its tumor cell concentration in colon cancer detection. PMID: 9057060 Ref: P53 mutations associated with breast, colorectal, liver, lung, and ovarian cancers. PMID: 9118874 Ref: Biological prospectives to define prognosis and treatment strategies in liver metastases from colorectal cancer. PMID: 9125689 Ref: [The effect of the tumor suppressor p53 and its mutant forms on the differentiation and viability of K562 leukemic cells]. PMID: 9163103 Ref: Spontaneous apoptosis in human colon tumor cell lines and the relation of wt p53 to apoptosis. PMID: 9206101 Ref: [Expression of p53 protein in colorectal cancer and its relationship to cell proliferative activity and prognosis]. PMID: 9387310 Ref: [Relations between p53 and p185 expression and prognosis of patients with colon cancers]. PMID: 9387311 Ref: Wild-type p53 demonstrates functional dominance in a human colon carcinoma cell line in which it induces reversible growth arrest. PMID: 9816111 Ref: Wild-type p53 protein potentiates cytotoxicity of therapeutic agents in human colon cancer cells. PMID: 9816112 Ref: Adenoviral-mediated wild-type p53 gene expression sensitizes colorectal cancer cells to ionizing radiation. PMID: 9816114 Ref: Increased apoptosis accompanies neoplastic development in the human colorectum. PMID: 9816159 Ref: Overexpression of the c-myc proto-oncogene in colorectal carcinoma is associated with a reduced mortality that is abrogated by point mutation of the p53 tumor suppressor gene. PMID: 9816266 Ref: Suppression of cancer cell growth by adenovirus expressing p21(WAF1/CIP1) deficient in PCNA interaction. PMID: 9816291 Ref: Prediction of Biologic Aggressiveness in Colorectal Cancer by p53/K-ras-2 Topographic Genotyping. PMID: 10330194 Ref: p53 gene alterations and protein accumulation in colorectal cancer. PMID: 16696056 Ref: Genes mediating programmed cell death: an immunohistochemical study of bcl-2, c-myc and p53 expression in colorectal neoplasia. PMID: 16696064 Ref: Bile acid activation of the gadd153 promoter and of p53-independent apoptosis: relevance to colon cancer. PMID: 17180111 Ref: Gel fiberglass as a new matrix of affinity chromatography columns for isolation of colon cancer-associated antigens. PMID: 21541495 Ref: Genetics of colorectal cancer (Review). PMID: 21541519 Ref: Effect of cytochrome P450 inducers on expression of oncogenes and a tumor suppressor gene in human colon cancer cells. PMID: 21541530 Ref: Mutation in the K-ras gene at codon 12 does not correlate with disease progression in colorectal carcinoma patients treated with 5-FU/folinic acid biomodulated chemotherapy. PMID: 21541641 Ref: HPLC determination of serum levels of soluble p53 antigen as a new method for colon cancer detection, and its clinical implication. PMID: 21544491 Ref: Increased induction of apoptosis of human colorectal cancer cells after preoperative treatment with 5-fluorouracil. PMID: 21594360 |
Ref: Humoral immune response against p53 protein in patients with colorectal carcinoma. PMID: 8985089 Ref: Prognostic markers for colorectal cancer: expression of P53 and BCL2. PMID: 8995081 Ref: p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer? PMID: 9000603 Ref: The p53-regulated cyclin G gene promotes cell growth: p53 downstream effectors cyclin G and Gadd45 exert different effects on cisplatin chemosensitivity. PMID: 9013707 Ref: Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. PMID: 9020077 Ref: Assessment of microsatellite alterations in young patients with gastric adenocarcinoma. PMID: 9024705 Ref: WAF1 expression and p53 mutations in human colorectal cancers. PMID: 9030251 Ref: K-ras and p53 mutations in hereditary non-polyposis colorectal cancers. PMID: 9036876 Ref: Conserved region mutations of the p53 gene are concentrated in distal colorectal cancers. PMID: 9036877 Ref: p53 haplotype determination in breast cancer. PMID: 9037561 Ref: Polymerase chain reaction-based approaches for detection of allelic loss in the p53 tumor suppressor gene in colon neoplasms. PMID: 9040212 Ref: Induction of p53-independent apoptosis associated with G2M arrest following DNA damage in human colon cancer cell lines. PMID: 9045894 Ref: Advances in molecular genetics. PMID: 9046882 Ref: Overexpression of p53 mRNA in colorectal cancer and its relationship to p53 gene mutation. PMID: 9052405 Ref: Accumulation of p53 in relation to long-term prognosis in colorectal carcinoma. PMID: 9058631 Ref: Pregnancy associated with colon carcinoma overexpressing p53. PMID: 9062163 Ref: Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B. PMID: 9063739 Ref: Effect of penclomedine (NSC-338720) on telomere fusions, chromatin blebbing, and cell viability with and without telomerase activity and abrogated p53 function. PMID: 9065745 Ref: Absence of p53 gene mutations in rat colon carcinomas induced through the synergistic interaction between methylazoxymethanol and X-irradiation. PMID: 9065795 Ref: Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis. PMID: 9070487 Ref: A rapid and nonisotopic method for the screening and sequencing of p53 gene mutations in formalin-fixed, paraffin-embedded tumors. PMID: 9071734 Ref: Immunohistochemical determination of p53 overexpression. An easy and readily available method to identify progression in superficial bladder cancer? PMID: 9079754 Ref: Association between sucrase-isomaltase and p53 expression in colorectal cancer. PMID: 9084856 Ref: K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients. PMID: 9097977 Ref: Single-step DGGE-based mutation scanning of the p53 gene: application to genetic diagnosis of colorectal cancer. PMID: 9101296 Ref: [Diagnostic problems associated with colorectal cancer]. PMID: 9101542 Ref: [Molecular-pathological problems of genetic diagnosis for colorectal cancer]. PMID: 9101543 Ref: Proliferating cell nuclear antigen expression and its relationship to malignancy potential in invasive colorectal carcinomas. PMID: 9102262 Ref: Meat consumption and preparation, and genetic susceptibility in relation to colorectal adenomas. PMID: 9103318 Ref: Mutated p53 gene is an independent adverse predictor of survival in colon carcinoma. PMID: 9108757 Ref: Oral contraceptives, reproductive factors and p53 gene expression in colorectal cancer. PMID: 9111225 Ref: Low-level c-myc amplification in human colonic carcinoma cell lines and tumors: a frequent, p53-independent mutation associated with improved outcome in a randomized multi-institutional trial. PMID: 9135021 Ref: Detection and monitoring of serum p53 antibodies in patients with colorectal cancer. PMID: 9135525 Ref: Genetic alterations in gastric cancer: relation to histological subtypes, tumor stage, and Helicobacter pylori infection. PMID: 9136822 Ref: Enterocyte differentiation is compatible with SV40 large T expression and loss of p53 function in human colonic Caco-2 cells. Status of the pRb1 and pRb2 tumor suppressor gene products. PMID: 9136893 Ref: Poorly differentiated colonic adenocarcinoma, medullary type: clinical, phenotypic, and molecular characteristics. PMID: 9137104 Ref: Genetic alterations and oxidative metabolism in sporadic colorectal tumors from a Spanish community. PMID: 9142218 Ref: Topographic genotyping of colorectal carcinoma: from a molecular carcinogenesis model to clinical relevance. PMID: 9142390 Ref: Pathological and genetic correlates of apoptosis in the progression of colorectal neoplasia. PMID: 9143411 Ref: Role of p21Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells. PMID: 9150394 Ref: K-ras mutation and loss of heterozygosity of chromosome 17p and survival in colorectal cancer. PMID: 9152151 Ref: Molecular genetics of colon cancer. PMID: 9156280 Ref: Cell proliferation-related markers in colorectal liver metastases: correlation with patient prognosis. PMID: 9164212 Ref: The regrowth of rectal adenocarcinoma after pre-operative radiotherapy with a report of two cases. PMID: 9164508 Ref: Mutant plasma p53 protein levels: prognostication in colorectal carcinoma. PMID: 9171756 Ref: Cells lacking CIP1/WAF1 genes exhibit preferential sensitivity to cisplatin and nitrogen mustard. PMID: 9174048 Ref: Cancer biology in ulcerative colitis and potential use in endoscopic surveillance. PMID: 9177146 Ref: Immunophenotyping of human HT29 colon cancer cell primary tumours and their metastases in severe combined immunodeficient mice. PMID: 9184853 Ref: Anti-p53 autoantibodies in colon cancer patients. PMID: 9186708 Ref: Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases. PMID: 9202067 Ref: Genetic alterations in sporadic and Crohn's-associated adenocarcinomas of the small intestine. PMID: 9207270 Ref: Assessment of mutations in Ki-ras and p53 in colon cancers from azoxymethane- and dimethylhydrazine-treated rats. PMID: 9210960 Ref: Coexpression of Bcl-2, c-Myc, and p53 oncoproteins as prognostic discriminants in patients with colorectal carcinoma. PMID: 9221853 Ref: Expression of p21WAF1/CIP1 in colorectal adenomas and adenocarcinomas and its correlation with p53 protein expression. PMID: 9234386 Ref: [Prognostic factors of advanced colorectal cancers]. PMID: 9248088 Ref: p53 and CD44 as clinical markers of tumour progression in colorectal carcinogenesis. PMID: 9248852 Ref: Lack of uncoupling of S phase and mitosis after irradiation in p53- human lymphoblast cell lines. PMID: 9254731 Ref: [Detection of nucleotide mutation by direct sequencing method using non-radio isotopic marker]. PMID: 9256014 Ref: 7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53. PMID: 9260909 Ref: [Findings of genetic changes in small intestinal carcinomas]. PMID: 9263525 Ref: Multiple tumor case: report and analysis of an autopsy case. PMID: 9267495 Ref: Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line. PMID: 9268365 Ref: Distinct effects of various p53 mutants on differentiation and viability of human K562 leukemia cells. PMID: 9268986 Ref: Stereologic estimates of volume-weighted mean nuclear volume in colorectal adenocarcinoma: correlation with histologic grading, Dukes' staging, cell proliferation activity and p53 protein expression. PMID: 9269906 Ref: Recent advances in molecular genetics of colorectal cancer. PMID: 9276697 Ref: Mutation frequencies at codon 248 of the p53 tumour suppressor gene are not increased in colon cancer cell lines with the RER+ phenotype. PMID: 9278485 Ref: The polyproline region of p53 is required to activate apoptosis but not growth arrest. PMID: 9285684 Ref: Female embryonic lethality in mice nullizygous for both Msh2 and p53. PMID: 9288110 Ref: Microsatellite instability in sporadic-colon-cancer patients with and without liver metastases. PMID: 9291442 Ref: Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas. PMID: 9294187 Ref: Molecular genetics of small bowel cancer. PMID: 9298583 Ref: Common patterns of genetic evolution in human solid tumors. PMID: 9298807 Ref: The status of p53 in the metastatic progression of colorectal cancer. PMID: 9301461 Ref: Effect of p53 overexpression on radiation sensitivity of human colon cancer cells. PMID: 9303056 Ref: Apoptosis in colorectal carcinoma occurring in patients aged 45 years and under: relationship to prognosis, mitosis, and immunohistochemical demonstration of p53, c-myc and bcl-2 protein products. PMID: 9306959 Ref: Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function. PMID: 9307289 Ref: Expression of Bcl-2 and p53 in the colorectal adenoma-carcinoma sequence. PMID: 9309780 Ref: Does p53 overexpression cause metastases in early invasive colorectal adenocarcinoma? PMID: 9311476 Ref: Concordance of genetic alterations in poorly differentiated colorectal neuroendocrine carcinomas and associated adenocarcinomas. PMID: 9326914 Ref: Experimental models of gene-environment interaction for cancer chemoprevention studies. PMID: 9327228 Ref: Predictive value of genetic diagnosis for cancer micrometastasis: histologic and experimental appraisal. PMID: 9338462 Ref: [Quantification of protein p53 expression by image analysis in 58 cases of colon carcinoma. Study of correlations between sex, age, histology, Dukes stage, DNA content and lymph node invasion]. PMID: 9338999 Ref: Isolation and characterization of new microsatellites at the nm23-H1 and nm23-H2 gene loci and application for loss of heterozygosity (LOH) analysis. PMID: 9341864 Ref: Alternative genetic pathways in colorectal carcinogenesis. PMID: 9342373 Ref: The role of p53, p21WAF1/C1PI, and bcl-2 in radioresistant colorectal carcinoma. PMID: 9343326 Ref: Loss of p21Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism. PMID: 9354425 Ref: Apoptosis induced by hyperthermia and verapamil in vitro in a human colon cancer cell line. PMID: 9354939 Ref: Combined analysis of p53 and vascular endothelial growth factor expression in colorectal carcinoma for determination of tumor vascularity and liver metastasis. PMID: 9355971 Ref: Novel combination therapy for human colon cancer with adenovirus-mediated wild-type p53 gene transfer and DNA-damaging chemotherapeutic agent. PMID: 9359484 Ref: Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: a p53-independent induction of p21WAF1/CIP1 via C/EBPbeta. PMID: 9359698 Ref: Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory. PMID: 9359923 Ref: [Colonic cancer: from molecular diagnosis to diagnostic and therapeutic procedure]. PMID: 9365717 Ref: p53 mutations detected in colorectal carcinoma patients in Hong Kong. PMID: 9367066 Ref: Expressions of cell cycle regulators in human colorectal cancer cell lines. PMID: 9369933 Ref: Genetic detection of colorectal cancer cells in circulation and lymph nodes. PMID: 9378009 Ref: Prevention of fluorodeoxyuridine-induced cytotoxicity and DNA damage in HT29 colon carcinoma cells by conditional expression of wild-type p53 phenotype. PMID: 9380022 Ref: p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents. PMID: 9380755 Ref: Immunohistochemical detection of p53 tumor suppressor gene protein in canine epithelial colorectal tumors. PMID: 9381650 Ref: [Continuous hepatic arterial infusion of fluorouracil with leucovorin for liver metastases from colorectal cancer]. PMID: 9382508 Ref: Activation of adenomatous polyposis coli (APC) gene expression by the DNA-alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine requires p53. PMID: 9388195 Ref: Modulation of p53 expression in cultured colonic adenoma cell lines by the naturally occurring lumenal factors butyrate and deoxycholate. PMID: 9398049 Ref: Carcinoma of the colon in childhood; report of 2 cases expressing p53 without K-ras mutation. PMID: 9402497 Ref: Colorectal carcinoma in Hong Kong: epidemiology and genetic mutations. PMID: 9413950 Ref: Drastic genetic instability of tumors and normal tissues in Turcot syndrome. PMID: 9419979 Ref: Heat shock protein 72/73 in relation to cytoplasmic p53 expression and prognosis in colorectal adenocarcinomas. PMID: 9421355 Ref: Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors. PMID: 9421366 Ref: Critical issues in the evolving management of rectal cancer. PMID: 9422268 Ref: Detection of p53 protein overexpression and DNA ploidy analysis in colon cancer. PMID: 9427029 Ref: K-ras and p53 gene mutations in colorectal cancer in 57 Japanese patients. PMID: 9431782 Ref: No involvement of APC gene mutations in ulcerative colitis-associated rat colon carcinogenesis induced by 1-hydroxyanthraquinone and methylazoxymethanol acetate. PMID: 9433483 Ref: Molecular biology of colorectal cancer. PMID: 9438104 Ref: Ki-ras oncogene and p53 tumour suppressor gene mutations in colorectal carcinomas from the European Saar-Luxembourg region are less frequent than predicted by the classic adenoma-carcinoma sequence model. PMID: 9470817 Ref: Molecular analysis in endometrial cancer. PMID: 9474873 Ref: [Immunohistochemical expression of p53 oncoprotein in large bowel adenomas and carcinomas]. PMID: 9497572 Ref: [Colorectal carcinogenesis, frequency and significance of genetic alterations: deletion of the short arm of chromosome 1, and initiating event]. PMID: 9554124 Ref: Immunophenotype of human HT29 colon cancer cell metastases in the lungs of scid mice: spontaneous versus artificial metastases. PMID: 9561026 Ref: [p53 mutation and chemoresistance in oral-maxillofacial squamous cell carcinoma. Role of p53 in the cell cycle control and in the modulating action of chemotherapeutic agents]. PMID: 9567617 Ref: Expression of p53 protein in rat colon cancer cell lines transfected with Rous sarcoma virus-33. PMID: 9570350 Ref: [Detection of protein p53 in the stool of patients with colorectal cancer]. PMID: 9587516 Ref: Genetic markers for early detection of lung cancer and outcome measures for response to chemoprevention. PMID: 9589350 Ref: Biomarkers for predicting response to regional chemo-immunotherapy in liver metastases from colorectal carcinoma. PMID: 9637342 Ref: 14-3-3sigma is a p53-regulated inhibitor of G2/M progression. PMID: 9659898 Ref: [Expression of p53 and bcl-2 in colorectal adenomas and carcinomas]. PMID: 9674186 Ref: [The molecular biology and genetics of colorectal carcinoma]. PMID: 9739886 Ref: [p53 and colorectal cancer]. PMID: 9769952 Ref: p53 immunohistochemical staining predicts residual disease after chemoradiation in patients with high-risk rectal cancer. PMID: 9815551 Ref: Inhibition of radiation-induced G2 delay potentiates cell death by apoptosis and/or the induction of giant cells in colorectal tumor cells with disrupted p53 function. PMID: 9815821 Ref: p53 alterations are associated with improved prognosis in distal colonic carcinomas. PMID: 9815825 Ref: Inactivation of p53 increases the cytotoxicity of camptothecin in human colon HCT116 and breast MCF-7 cancer cells. PMID: 9815856 Ref: Prognostic significance of tumor markers in colorectal cancer patients: DNA index, S-phase fraction, p53 expression, and Ki-67 index. PMID: 9834357 Ref: [Apoptosis and expression of its regulating genes in adenoma and adenocarcinoma of large intestine]. PMID: 10072852 Ref: [A comparative study on p53 gene mutation in primary human Dukes C colon cancer with that in matched lymph node metastasis]. PMID: 10072877 Ref: [Inhibition effect of p53 antisense RNA on malignant phenotype of colorectal cancer cells]. PMID: 10743076 Ref: Immunological implications of alterations in the c-Ki-ras and p53 genes in the stepwise progression of colorectal cancer: indications for the improvement of prognosis, biotherapy treatment and tumor biology understanding PMID: 10851492 Ref: Wild-type p53 is not sufficient for serum starvation-induced apoptosis in cancer cells but accelerates apoptosis in sensitive cells. PMID: 21528317 Ref: Second-look hepatectomy after 5FU arterial infusion in patients with primary unresectable hepatic colorectal metastases. PMID: 21533352 Ref: Modulation of alterations in p53 tumor suppressor gene and its association with activation of ras proto-oncogenes during chemoprevention of colon cancer. PMID: 21533396 Ref: A possible correlation between p53 overexpression and prognosis after radiotherapy combined surgery for rectal carcinoma. PMID: 21533472 Ref: The role of p53 tumor-associated protein in colon cancer detection and prevention (Review). PMID: 21533511 Ref: Evaluation of DNA polymerase beta gene mutation as a genetic marker for colorectal carcinoma. PMID: 21590066 Ref: Preliminary study on the loss of heterozygosity at 17p13 in gastric and colorectal cancers. PMID: 27239133 |
Ref: p53 expression in human carcinomas: could flow cytometry be an alternative to immunohistochemistry? PMID: 9405493 Ref: Molecular changes during the genesis of human gliomas. PMID: 9407626 Ref: Quantification and characterization of total cellular p53 protein in colorectal cancer. PMID: 9450526 Ref: Proapoptotic gene BAX is frequently mutated in hereditary nonpolyposis colorectal cancers but not in adenomas. PMID: 9453486 Ref: Analysis of histological therapeutic effect, apoptosis rate and p53 status after combined treatment with radiation, hyperthermia and 5-fluorouracil suppositories for advanced rectal cancers. PMID: 9459162 Ref: p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells. PMID: 9467956 Ref: Decreased expression of the adenomatous polyposis coli (Apc) and mutated in colorectal cancer (Mcc) genes in mouse lung neoplasia. PMID: 9473770 Ref: [Molecular diagnosis of gastrointestinal cancers]. PMID: 9474927 Ref: [Molecular therapy for human cancer with tumor suppressor p53 gene transfer]. PMID: 9474928 Ref: p53-dependent elevation of p21Waf1 expression by UV light is mediated through mRNA stabilization and involves a vanadate-sensitive regulatory system. PMID: 9488455 Ref: p53, vessel count, and vascular endothelial growth factor expression in human colon cancer. PMID: 9495355 Ref: Heterogeneous induction of apoptosis in colon cancer cells by wild-type p53 gene transfection. PMID: 9499436 Ref: p53 genetic alterations, protein expression and autoantibodies in human colorectal carcinoma: A comparative study. PMID: 9499437 Ref: Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer. PMID: 9500462 Ref: Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase. PMID: 9508765 Ref: Role of p53 and p21/WAF1 detection in patient selection for preoperative radiotherapy in rectal cancer patients. PMID: 9510313 Ref: Alteration of p53 clonality accompanying colorectal cancer progression. PMID: 9510474 Ref: [The study of genetic changes in colorectal cancer accompanied with ulcerative colitis]. PMID: 9513564 Ref: Molecular pathogenesis of sporadic duodenal cancer. PMID: 9514055 Ref: Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study. PMID: 9515799 Ref: TP53 and long-term prognosis in colorectal cancer: mutations in the L3 zinc-binding domain predict poor survival. PMID: 9516972 Ref: Absence of frequent involvement of modifier of Min(APC) in sporadic colorectal cancer. PMID: 9527272 Ref: Nuclear factor - kappaB-dependent regulation of p53 gene expression induced by daunomycin genotoxic drug. PMID: 9528861 Ref: Comparative analysis of histology, DNA content, p53 and Ki-ras mutations in colectomy specimens with long-standing ulcerative colitis. PMID: 9533753 Ref: Molecular detection of genetic alterations in the serum of colorectal cancer patients. PMID: 9537240 Ref: Increased serum levels of mutant p53 proteins in patients with colorectal cancer. PMID: 9539318 Ref: Differential photosensitivity in wild-type and mutant p53 human colon carcinoma cell lines. PMID: 9540217 Ref: Mismatch repair deficiency leads to a unique mode of colorectal tumorigenesis characterized by intratumoral heterogeneity. PMID: 9546427 Ref: Human smooth muscle alpha-actin gene is a transcriptional target of the p53 tumor suppressor protein. PMID: 9546431 Ref: Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma. PMID: 9552053 Ref: Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells. PMID: 9558281 Ref: Comparative survival analysis of p53 gene mutations and protein accumulation in colorectal cancer. PMID: 9560058 Ref: A genetic perspective of male germ cell tumors. PMID: 9562446 Ref: Disruption of p53 function in immortalized human cells does not affect survival or apoptosis after taxol or vincristine treatment. PMID: 9563901 Ref: Genetic alterations are frequent in APC but rare in the TGF-beta type II receptor gene in cancer in adenomas of the colon. PMID: 9566701 Ref: Immunoperoxidase staining for cytokeratins 8 and 18 is very sensitive for detection of occult node metastasis of colorectal cancer: a comparison with genetic analysis of K-ras. PMID: 9568504 Ref: Abrogation of c-Raf expression induces apoptosis in tumor cells. PMID: 9583688 Ref: The prognostic significance of p53 expression for survival and local control in rectal carcinoma treated with surgery and postoperative radiotherapy. PMID: 9588914 Ref: Genetic alterations in a patient with Turcot's syndrome. PMID: 9589476 Ref: The association between telomerase, p53, and clinical staging in colorectal cancer. PMID: 9600278 Ref: A comparison of the genetic pathways involved in the pathogenesis of three types of colorectal cancer. PMID: 9602705 Ref: p53 and thymidylate synthase expression in untreated stage II colon cancer: associations with recurrence, survival, and site. PMID: 9607581 Ref: p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival. PMID: 9607583 Ref: Loss of p21WAF1/Cip1 protein expression accompanies progression of sporadic colorectal neoplasms but not hereditary nonpolyposis colorectal cancers. PMID: 9607584 Ref: p53 protein overexpression and response to induction chemoradiation therapy in patients with locally advanced rectal adenocarcinoma. PMID: 9607618 Ref: Immunohistochemical study of p53 overexpression in radiation-induced colon cancers. PMID: 9610028 Ref: Characterization of human colon cancer antigens recognized by autologous antibodies. PMID: 9610721 Ref: Conjunction dysfunction: CBP/p300 in human disease. PMID: 9613201 Ref: Identification and characterization of families with aggregation of lung cancer. PMID: 9614442 Ref: Growth patterns and genetic changes of colorectal carcinoma. PMID: 9614443 Ref: Genetic instability, p53 and nm23 mutation and clinicopathological features in rectal carcinoma. PMID: 9615752 Ref: Aspirin use and p53 expression in colorectal cancer. PMID: 9618042 Ref: p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. PMID: 9618491 Ref: Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer. PMID: 9622060 Ref: Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. PMID: 9622070 Ref: Preparation of heat-labile antigens on air-dried cytologic specimens for immunocytochemical analysis. PMID: 9622692 Ref: [Molecular mechanisms of carcinogenesis: the role of systems of DNA repair]. PMID: 9622930 Ref: Accumulating mutations of p53 in colon tumor and hairy cell leukemia do not arise from methylation/deamination processes, but rather from nucleotide deletions and insertions. PMID: 9628350 Ref: A histopathological assessment of the response of rectal adenocarcinoma to combination chemo-radiotherapy: relationship to apoptotic activity, p53 and bcl-2 expression. PMID: 9630854 Ref: Apoptosis, proliferation, bax, bcl-2 and p53 status prior to and after preoperative radiochemotherapy for locally advanced rectal cancer. PMID: 9635706 Ref: The effect of activation of wild-type p53 function on fluoropyrimidine-mediated radiosensitization. PMID: 9635719 Ref: [Proliferation and apoptosis before and after preoperative simultaneous radiochemotherapy of rectal carcinomas]. PMID: 9645209 Ref: Genetic alterations in colorectal cancer, comparative analysis of deletion events, and point mutations. PMID: 9648555 Ref: Moderate amplifications of the c-myc gene correlate with molecular and clinicopathological parameters in colorectal cancer. PMID: 9649157 Ref: Primary cancer of the small intestine and mutational analysis of the K-ras and p53 genes. PMID: 9658320 Ref: Somatic mutations, acetylator status, and prognosis in colorectal cancer. PMID: 9659162 Ref: Mitochondrial membrane potential (delta psi(mt)) in the coordination of p53-independent proliferation and apoptosis pathways in human colonic carcinoma cells. PMID: 9661904 Ref: Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells. PMID: 9664116 Ref: Mutational analysis of the p73 gene localized at chromosome 1p36.3 in colorectal carcinomas. PMID: 9664127 Ref: Mutation of the transforming growth factor-beta type II receptor gene in right-sided colorectal cancer: relationship to clinicopathological features and genetic alterations. PMID: 9664904 Ref: Immunohistochemical detection of p53 and Bcl-2 in colorectal carcinoma: no evidence for prognostic significance. PMID: 9667656 Ref: Increased serum p53 antibody levels indicate poor prognosis in patients with colorectal cancer. PMID: 9667657 Ref: Bcl-2 protein expression: association with p53 and prognosis in colorectal cancer. PMID: 9667660 Ref: Up-regulation of the tumor suppressor gene p53 and WAF1 gene expression by IP6 in HT-29 human colon carcinoma cell line. PMID: 9673359 Ref: Absence of frameshift mutations in the bax gene in renal cell cancer (RCC) and transitional cell cancer (TCC). PMID: 9673385 Ref: DNA flow cytometry, p53 levels and proliferative cell nuclear antigen in human colon dysplastic, precancerous and cancerous tissues. PMID: 9673389 Ref: [Genetic alterations and molecular mechanisms underlying colorectal tumorigenesis]. PMID: 9676181 Ref: Cooperation of a single lysine mutation and a C-terminal domain in the cytoplasmic sequestration of the p53 protein. PMID: 9677415 Ref: Evaluation of p53, Ki-67 and DNA ploidy in both primary rectal carcinomas and locally recurrent tumors. PMID: 9683840 Ref: Gene therapy for colon cancer. PMID: 9684100 Ref: Expression of hypoxia-inducible genes in tumor cells. PMID: 9692838 Ref: [A novel approach for cancer chemoprevention referred to as "gene-regulating chemoprevention"]. PMID: 9695075 Ref: Chromosome 18q allelic loss and prognosis in stage II and III colon cancer. PMID: 9699532 Ref: Allelotype analysis of early colorectal cancers with lymph node metastasis. PMID: 9699536 Ref: K-ras codon 12 mutation determines the polypoid growth of colorectral cancer. PMID: 9699657 Ref: [Significance of p53 and VEGF expression in liver metastasis from colorectal cancer]. PMID: 9703827 Ref: Growth dependency of human colon cancer xenograft on organ environment is related with their original clinical stage. PMID: 9703939 Ref: Isolation of a novel TP53 target gene from a colon cancer cell line carrying a highly regulated wild-type TP53 expression system. PMID: 9713990 Ref: Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53. PMID: 9715273 Ref: Natural history of colorectal carcinoma: can the tumor volume doubling time be predicted by radiologic findings or immunohistochemical variables? PMID: 9721706 Ref: Genetic abnormalities and microsatellite instability in colorectal cancer. PMID: 9727619 Ref: Microsatellite instability and p53 mutations in sporadic right and left colon carcinoma: different clinical and molecular implications. PMID: 9731891 Ref: No evidence for overexpression of the p53 protein and mutations in exons 4-9 of the p53 gene in a large family with adenomatous polyposis. PMID: 9732936 Ref: Effects of pharmacokinetic modulating chemotherapy using oral UFT and continuous venous 5FU infusion on the prognosis of irradiated rectal carcinomas with p53 overexpression. PMID: 9735391 Ref: Protein synthesis and transcriptional inhibitors control N-methyl-N'-nitro-N-nitrosoguanidine-induced levels of APC mRNA in a p53-dependent manner. PMID: 9735403 Ref: p53 mutation in patients with ulcerative colitis in rectal biopsy. PMID: 9735666 Ref: Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases. PMID: 9736017 Ref: Microsatellite instability in young patients with colorectal cancer. PMID: 9736405 Ref: [Messenger RNA expression of p21WAF1/CIP1 in colorectal carcinoma tissues]. PMID: 9742528 Ref: [Molecular surgery for human colorectal cancer with tumor suppressor p53 gene transfer]. PMID: 9742529 Ref: Nuclear targeting of Bax during apoptosis in human colorectal cancer cells. PMID: 9747879 Ref: Telomerase activity significantly correlates with cell differentiation, proliferation and lymph node metastasis in colorectal carcinomas. PMID: 9750021 Ref: p53 exon 7 mutations as a predictor of poor prognosis in patients with colorectal cancer. PMID: 9751268 Ref: Clinical relevance of transforming growth factor alpha, epidermal growth factor receptor, p53, and Ki67 in colorectal liver metastases and corresponding primary tumors. PMID: 9755233 Ref: Epidemiological study of p53 tumor suppressor gene mutations in patients from Luxembourg and the German Saar region with an advanced colorectal cancer using PCR-SSCP analysis. PMID: 9755819 Ref: Advantages of immunostaining over DNA analysis using PCR amplification to detect p53 abnormality in long-term formalin-fixed tissues of human colorectal carcinomas. PMID: 9773930 Ref: Importance of cytogenetic markers for multiple primary carcinomas in colorectal cancer: chromosome 17 and p53 locus translocation. PMID: 9773931 Ref: [Genetic alterations in the region of the p53 gene on human chromosome 17 in colorectal cancer]. PMID: 9777351 Ref: Accumulated clonal genetic alterations in familial and sporadic colorectal carcinomas with widespread instability in microsatellite sequences. PMID: 9777938 Ref: Clinical, histopathological, cytogenetic and prognostic differences between mucinous and nonmucinous colorectal adenocarcinomas. PMID: 9780789 Ref: Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers. PMID: 9788444 Ref: 5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteins. PMID: 9792140 Ref: Gel fiberglass membranes for affinity chromatography columns and their application to cancer detection. PMID: 9792517 Ref: Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells. PMID: 9792801 Ref: [Expression of protein p53 in the adenoma-colorectal carcinoma sequence]. PMID: 9793394 Ref: Dexamethasone-mediated protection from drug cytotoxicity: association with p21WAF1/CIP1 protein accumulation? PMID: 9794234 Ref: Enhanced growth inhibition and differentiation of fluorodeoxyuridine-treated human colon carcinoma cells by phenylbutyrate. PMID: 9796984 Ref: Nuclear p53 protein expression in resected hepatic metastases from colorectal cancer: an independent prognostic factor of survival. PMID: 9797697 Ref: Retinoblastoma and p53 protein expression in sporadic colorectal cancers. PMID: 9800976 Ref: Long-term analysis of colonic aberrant crypt formation after treatment of Sprague-Dawley rats with azoxymethane. PMID: 9804274 Ref: [Clinicopathological significance of p53 overexpression in elderly patients with colorectal cancer]. PMID: 9805927 Ref: Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer. PMID: 9823313 Ref: [Analysis of genetic disorders of cancer of the rectum: differences in relation to cancer of the colon]. PMID: 9823556 Ref: Growth patterns in various macroscopic types of noninvasive intramucosal colorectal carcinoma with special reference to apoptosis and cell proliferation. PMID: 9823803 Ref: Expression of the mismatch repair gene hMSH2 in sporadic colorectal cancer. PMID: 9824623 Ref: Multifocal neoplasia involving the colon and appendix in ulcerative colitis: pathological and molecular features. PMID: 9834286 Ref: p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. PMID: 9841917 Ref: [Evaluation of yeast functional assay to detect p53 gene mutation in minute endoscopic samples of colonic mucosal neoplasia]. PMID: 9846280 Ref: Loss of heterozygosity and microsatellite instability in de novo versus ex-adenoma carcinomas of the colorectum. PMID: 9846987 Ref: Alterations in tumour suppressor gene p53 correlate with inhibition of thrombospondin-1 gene expression in colon cancer cells. PMID: 9849855 Ref: Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome. PMID: 9850045 Ref: p53 gene mutations in rectal cancer associated with schistosomiasis japonica in Chinese patients. PMID: 9851256 Ref: The role of the soluble p53 antigen and its autoantibodies as markers for diagnosis of colon cancer: a comparative study. PMID: 9852249 Ref: Loss of Bcl-2 expression correlates with tumour recurrence in colorectal cancer. PMID: 9863484 Ref: Imbalance between proliferation and apoptosis in the development of colorectal carcinoma. PMID: 9870685 Ref: Nuclear accumulation of p53 in colorectal adenocarcinoma: prognostic importance differs with race and location of the tumor. PMID: 9874449 Ref: A novel mutant from apoptosis-resistant colon cancer HT-29 cells showing hyper-apoptotic response to hypoxia, low glucose and cisplatin. PMID: 9914786 Ref: Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor. PMID: 10072587 Ref: Effects of perturbations of pools of deoxyribonucleoside triphosphates on expression of ribonucleotide reductase, a G1/S transition state enzyme, in p53-mutated cells. PMID: 10076525 Ref: Ki-ras and p53 gene mutations in pancreatic ductal carcinoma: a relationship with tumor phenotype and survival. PMID: 10076772 Ref: Mutations of the adenomatous polyposis coli and p53 genes in a child with Turcot's syndrome. PMID: 10397462 Ref: [Expression and significance of p53, c-erbB2, CEA proteins in colorectal adenoma and carcinoma]. PMID: 10681823 Ref: [Multivariate analysis of clinicopathological and immunohistochemical factors in colorectal carcinomas]. PMID: 11244942 Ref: [Bcl-2 inhibits p53-induced apoptosis after genotoxic damage by inhibitors of nuclear import of p53]. PMID: 14518224 Ref: Anti-Fas antibody-induced apoptosis in human colorectal carcinoma cell lines: role of the p53 gene. PMID: 14646476 |
Ref: Penclomedine-induced DNA fragmentation and p53 accumulation correlate with reproductive cell death in colorectal carcinoma cells with altered p53 status. PMID: 9864421 Ref: Prospective study of intratumoral microvessel density, p53 expression and survival in colorectal cancer. PMID: 9888475 Ref: Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer. PMID: 9890175 Ref: Thymidylate synthase protein and p53 mRNA form an in vivo ribonucleoprotein complex. PMID: 9891091 Ref: Changes of angiogenesis and tumor cell apoptosis during colorectal carcinogenesis. PMID: 9918211 Ref: Symptomatic colonic polyps in childhood: not so benign. PMID: 9932851 Ref: Molecular characteristics of poorly differentiated adenocarcinoma and signet-ring-cell carcinoma of colorectum. PMID: 9988229 Ref: Clinicopathological variables and p53 overexpression as a combined prognosticator for hematogenic recurrence in colorectal cancer. PMID: 9989413 Ref: Distinct chromosomal alterations associated with TP53 status of LoVo cells under PALA selective pressure: a parallel with cytogenetic pathways of colorectal cancers. PMID: 9989828 Ref: Evaluation of the usefulness of testing for p53 mutations in colorectal cancer surveillance for ulcerative colitis. PMID: 10022646 Ref: L-myc genotypes in Hong Kong Chinese colorectal carcinoma patients. PMID: 10023018 Ref: p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent. PMID: 10023682 Ref: Assessment of microsatellite instability and loss of heterozygosity in sporadic keratoacanthomas. PMID: 10025721 Ref: [Genetic alterations in human malignant tumor]. PMID: 10067361 Ref: Hepatitis B virus X protein inhibits nucleotide excision repair. PMID: 10074921 Ref: Detection of serum p53 antibodies in mucosal colorectal cancer and negative conversion after endoscopic resection. PMID: 10078825 Ref: Prognostic value of p53 genetic changes in colorectal cancer. PMID: 10080604 Ref: Prognostic significance of p53 gene mutations in laryngeal cancer. PMID: 10089975 Ref: Regulation of p53 expression by thymidylate synthase. PMID: 10097112 Ref: Clinicopathological features of superficial depressed-type colorectal neoplastic lesions. PMID: 10201461 Ref: MUC1 expression in intramucosal colorectal neoplasms. Possible involvement in histogenesis and progression. PMID: 10202278 Ref: Loci for efficient detection of microsatellite instability in hereditary non-polyposis colorectal cancer. PMID: 10203581 Ref: Usefulness of p53 protein, Bcl-2 protein and Ki-67 as predictors of chemosensitivity of malignant tumors. PMID: 10203614 Ref: Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a). PMID: 10207115 Ref: High gastrin releasing peptide receptor mRNA level is related to tumour dedifferentiation and lymphatic vessel invasion in human colon cancer. PMID: 10211100 Ref: Cyclooxygenase (COX)-2 immunoreactivity and relationship to p53 and Ki-67 expression in colorectal cancer. PMID: 10213117 Ref: Cooperation between p53 and hMLH1 in a human colocarcinoma cell line in response to DNA damage. PMID: 10213232 Ref: K-ras and p53 mutations and overexpressions as prognostic factors in female rectal carcinoma. PMID: 10216477 Ref: No-touch isolation technique reduces intraoperative shedding of tumor cells into the portal vein during resection of colorectal cancer. PMID: 10216526 Ref: Infrequent somatic mutations of the p73 gene in various human cancers. PMID: 10218465 Ref: The significance of microsatellite instability in predicting the development of metachronous multiple colorectal carcinomas in patients with nonfamilial colorectal carcinoma. PMID: 10223230 Ref: Detection of p53 mutations in Hong Kong colorectal carcinomas by conventional PCR-SSCP analysis versus p53 yeast functional assays. PMID: 10226610 Ref: Mucinous carcinoma of the colon in a 16-year-old Turkish boy with Bloom syndrome: cytogenetic, histopathologic, TP53 gene and protein expression studies. PMID: 10326590 Ref: Differential involvement of the CD95 (Fas/APO-1) receptor/ligand system on apoptosis induced by the wild-type p53 gene transfer in human cancer cells. PMID: 10327065 Ref: p53 over-expression and p53 mutations in colon carcinomas: relation to dietary risk factors. PMID: 10328215 Ref: Correlations between p53-protein accumulation, serum antibodies and gene mutation in colorectal cancer. PMID: 10328221 Ref: Microsatellite instability in endometrial cancer: relation to histological subtypes. PMID: 10329042 Ref: Dysregulation of beta-catenin is common in canine sporadic colorectal tumors. PMID: 10332831 Ref: Analysis of the p53/BAX pathway in colorectal cancer: low BAX is a negative prognostic factor in patients with resected liver metastases. PMID: 10334520 Ref: p53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer. PMID: 10334521 Ref: Protein synthesis inhibitor-mediated stability of adenomatous polyposis coli mRNA levels in HCT-116 colon cancer cells. PMID: 10339655 Ref: Failure of wild-type p53 gene therapy in human cancer cells expressing a mutant p53 protein. PMID: 10341872 Ref: Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features. PMID: 10348818 Ref: Familial gastric cancer: clinicopathological characteristics, RER phenotype and germline p53 and E-cadherin mutations. PMID: 10357799 Ref: Excess beta-catenin promotes accumulation of transcriptionally active p53. PMID: 10357817 Ref: An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis. PMID: 10359525 Ref: Boswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity. PMID: 10360653 Ref: Growth dysregulation and p53 accumulation in human primary colorectal cancer. PMID: 10362117 Ref: Establishment and characterization of 12 human colorectal-carcinoma cell lines. PMID: 10362137 Ref: The influence of the p53 gene on the in vitro chemosensitivity of colorectal cancer cells. PMID: 10363568 Ref: Morphological and genetic abnormalities in prediction of recurrence in radically operated colorectal cancer. PMID: 10365106 Ref: Correlation between DNA content and p53 deletion in colorectal cancer. PMID: 10365839 Ref: Loss of heterozygosity of TP53 is not correlated with clinicopathological variables in sporadic colorectal carcinomas. PMID: 10368694 Ref: Reappraisal of K-ras and p53 gene mutations in the recurrence of Dukes' B2 rectal cancer after curative resection. PMID: 10370622 Ref: Clinicopathologic and carcinogenetic appraisal of DNA replication error in sporadic T3N0M0 stage colorectal cancer after curative resection. PMID: 10370632 Ref: Carcinogenesis of intestinal-type gastric cancer and colorectal cancer is commonly accompanied by expression of brain (fetal)-type glycogen phosphorylase. PMID: 10374690 Ref: Apoptosis in relation to proliferating cell nuclear antigen and Dukes' stage in colorectal adenocarcinoma. PMID: 10375593 Ref: Wild-type p53 protein potentiates phototoxicity of 2-BA-2-DMHA in HT29 cells expressing endogenous mutant p53. PMID: 10378792 Ref: Expression of p53, p21/waf, bcl-2, bax, Rb and Ki67 proteins in colorectal adenocarcinomas. PMID: 10382939 Ref: KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules. PMID: 10383157 Ref: Clinical significance of serum p53 antibody detection on chemosensitivity assay in human colorectal cancer. PMID: 10389868 Ref: An ultra-metastatic model of human colon cancer in nude mice. PMID: 10390146 Ref: Loss of P27Kip1 expression correlates with tumor grade and with reduced disease-free survival in primary superficial bladder cancers. PMID: 10397272 Ref: p21WAF1/CIP1 expression in colorectal carcinoma correlates with advanced disease stage and p53 mutations. PMID: 10398083 Ref: [The relationship between p53 protein and c-erb B-2 expression and apoptosis in colorectal cancer]. PMID: 10401235 Ref: Expression of the HMGI(Y) gene in human colorectal cancer. PMID: 10404089 Ref: Genomic instability and alterations in Apc, Mcc and Dcc in Hong Kong patients with colorectal carcinoma. PMID: 10404094 Ref: Microsomal epoxide hydrolase gene polymorphism and susceptibility to colon cancer. PMID: 10408710 Ref: Comprehensive TP53-denaturing gradient gel electrophoresis mutation detection assay also applicable to archival paraffin-embedded tissue. PMID: 10408787 Ref: Villous tumor of the colon and rectum with special reference to roles of p53 and bcl-2 in adenoma-carcinoma sequence. PMID: 10417679 Ref: Paclitaxel sensitivity correlates with p53 status and DNA fragmentation, but not G2/M accumulation. PMID: 10421546 Ref: p53 point mutation and survival in colorectal cancer patients: effect of disease dissemination and tumour location. PMID: 10427130 Ref: [Pathogenesis of malignant melanoma. Molecular biology aspect]. PMID: 10427507 Ref: Apoptotic and mitotic indices predict survival rates in lymph node-negative colon carcinomas. PMID: 10430084 Ref: Disruption of p53 in human cancer cells alters the responses to therapeutic agents. PMID: 10430607 Ref: Clinicopathologic and immunohistochemical study of early colorectal cancer with liver metastases. PMID: 10433008 Ref: [Establishment of alpha-fetoprotein producing human rectal cancer cell line (RKK-YK) and its features]. PMID: 10434556 Ref: P53 and beta catenin expression in chronic ulcerative colitis--associated polypoid dysplasia and sporadic adenomas: an immunohistochemical study. PMID: 10435567 Ref: p53 status: an indicator for the effect of preoperative radiotherapy of rectal cancer. PMID: 10435809 Ref: Generation of anti-p53 Fab fragments from individuals with colorectal cancer using phage display. PMID: 10438972 Ref: Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene. PMID: 10441517 Ref: p27 modulates cell cycle progression and chemosensitivity in human malignant glioma. PMID: 10441521 Ref: Protein markers in colorectal cancer: predictors of liver metastasis. 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PMID: 10665650 Ref: LOH at the sites of the DCC, APC, and TP53 tumor suppressor genes occurs in Barrett's metaplasia and dysplasia adjacent to adenocarcinoma of the esophagus. PMID: 10667431 Ref: Immunohistochemical detection of mutant p53 protein in regional lymph nodes is associated with adverse outcome in stage II colorectal cancer. PMID: 10682269 Ref: Identification of seven genes regulated by wild-type p53 in a colon cancer cell line carrying a well-controlled wild-type p53 expression system. PMID: 10691030 Ref: A colorectal cell line with alterations in E-cadherin and epithelial biology may be an in vitro model of colitis. PMID: 10694944 Ref: Effect of extracellular NADH on human tumor cell proliferation. PMID: 10697561 Ref: Prognostic evaluation of metallothionein expression in human colorectal neoplasms. PMID: 10711249 Ref: [Are there differences between ex adenoma and de novo colorectal carcinomas?]. PMID: 10714204 Ref: [Determination of proliferative activity using Ki67 and expression of p53 in colorectal cancer]. PMID: 10751898 Ref: Sequence of molecular genetic events in colorectal tumorigenesis. PMID: 10772417 Ref: p53 autoantibodies in patients with autoimmune diseases: a quantitative approach. PMID: 10789988 Ref: Racial and ethnic factors in the genetic pathogenesis of colorectal cancer. PMID: 10826011 Ref: p53-independent inhibition of proliferation and p21(WAF1/Cip1)-modulated induction of cell death by the antioxidants N-acetylcysteine and vitamin E. PMID: 10935502 Ref: [NF-kappa B and cancers]. PMID: 10992882 Ref: [p53 mutations and protein overexpression in primary colorectal cancer and its liver metastasis]. PMID: 11776850 Ref: [The accessory diagnosis of rectal carcinoma by ICM and oncogene expressions]. PMID: 11829854 Ref: [Chemotherapeutic failure in micrometastasis in peripheral blood of patients with colorectal carcinomas]. 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PMID: 11263856 Ref: Telomerase activity and p53 gene mutation in familial polyposis coli. PMID: 11268463 Ref: Intratumor heterogeneity of k-ras and p53 mutations among human colorectal adenomas containing early cancer. PMID: 11310641 Ref: Inhibition of X-ray and doxorubicin-induced apoptosis by butyrolactone I, a CDK-specific inhibitor, in human tumor cells. PMID: 11329882 Ref: Angiogenesis and p53 expression in the colorectal adenoma-carcinoma sequence. PMID: 11341470 Ref: [P53 tumor suppressor gene in digestive neoplasms]. PMID: 11347516 Ref: [p53 gene mutation in cancer of the colon and rectum]. PMID: 11349504 Ref: Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates. PMID: 11417748 Ref: The history, mechanism and clinical use of oral 5-fluorouracil derivative chemotherapeutic agents. PMID: 11467334 Ref: Change of apoptotic status in the human colorectal adenoma-carcinoma sequences and its correlation with carcinogenesis and prognosis. PMID: 11775833 Ref: [Comparative study of metastasis-associated characteristics of tumor cells with different metastatic capacities]. PMID: 11778231 Ref: [Functional status of p53 and chemosensitivity of colon cancer cell lines]. PMID: 11778275 Ref: [Genes of micrometastasis in bone marrow of patients with colorectal cancer]. PMID: 11832027 |
Ref: Cloning and characterization of the human activity-dependent neuroprotective protein. PMID: 11013255 Ref: A retro-inverso peptide homologous to helix 1 of c-Myc is a potent and specific inhibitor of proliferation in different cellular systems. PMID: 11099487 Ref: p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma. PMID: 11139340 Ref: Effect of 2'-O-methyl antisense ORNs on expression of thymidylate synthase in human colon cancer RKO cells. PMID: 11139611 Ref: Molecular characterization of colorectal neoplasia in translational research. PMID: 11151060 Ref: Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1. PMID: 11158615 Ref: Proteasome inhibitor induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5. PMID: 11161273 Ref: Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer. PMID: 11161382 Ref: Genomic structure and loss of heterozygosity of EPHB2 in colorectal cancer. PMID: 11166921 Ref: Long lasting p53-specific T cell memory responses in the absence of anti-p53 antibodies in patients with resected primary colorectal cancer. PMID: 11169448 Ref: Cancer cells surviving hypoxia obtain hypoxia resistance and maintain anti-apoptotic potential under reoxygenation. PMID: 11169954 Ref: Differential expression of Hox A5 in human colon cancer cell differentiation: a quantitative study using real-time RT-PCR. PMID: 11179495 Ref: Microsatellite instability of each tumor in sporadic synchronous multiple colorectal cancers. PMID: 11182044 Ref: Modulation of protein kinase C in antitumor treatment. PMID: 11190577 Ref: Effects of folate supplementation on two provisional molecular markers of colon cancer: a prospective, randomized trial. PMID: 11197251 Ref: Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression. PMID: 11205907 Ref: Ternary combination of irinotecan, fluorouracil-folinic acid and oxaliplatin: results on human colon cancer cell lines. PMID: 11207057 Ref: K-ras and p16 aberrations confer poor prognosis in human colorectal cancer. PMID: 11208819 Ref: Differential p53-dependent mechanism of radiosensitization in vitro and in vivo by the protein kinase C-specific inhibitor PKC412. PMID: 11212276 Ref: Monitoring of p53 autoantibodies after resection of colorectal cancer: relationship to operative curability. PMID: 11213822 Ref: Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome. PMID: 11215281 Ref: Dual antitumor effects of 5-fluorouracil on the cell cycle in colorectal carcinoma cells: a novel target mechanism concept for pharmacokinetic modulating chemotherapy. PMID: 11221829 Ref: Mutations of p53 in morphologically non-neoplastic mucosa of long-standing ulcerative colitis. PMID: 11223540 Ref: Heterogeneity of p53 mutational status in intramucosal carcinoma of the colorectum. PMID: 11223545 Ref: Characterization of CD8+ cytotoxic T lymphocyte/tumor cell interactions reflecting recognition of an endogenously expressed murine wild-type p53 determinant. PMID: 11225991 Ref: Gene expression analysis in colorectal cancer using practical DNA array filter. PMID: 11227951 Ref: Novel method for simultaneous analysis of p53 and K-ras mutations and p53 protein expression in single histologic sections. PMID: 11231481 Ref: Synergistic efficacy of 3n-butyrate and 5-fluorouracil in human colorectal cancer xenografts via modulation of DNA synthesis. PMID: 11231942 Ref: Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer. PMID: 11232644 Ref: Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer. PMID: 11237386 Ref: The role of p21(CIP1/WAF1) in growth of epithelial cells exposed to hyperoxia. PMID: 11238001 Ref: Differential sensitivities of the MRP gene family and gamma-glutamylcysteine synthetase to prooxidants in human colorectal carcinoma cell lines with different p53 status. PMID: 11239498 Ref: P53 mutations in primary tumors and subsequent liver metastases are related to survival in patients with colorectal carcinoma who undergo liver resection. PMID: 11241240 Ref: Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. PMID: 11245456 Ref: P53 modulates the effect of loss of DNA mismatch repair on the sensitivity of human colon cancer cells to the cytotoxic and mutagenic effects of cisplatin. PMID: 11245458 Ref: Antiproliferative activity and interactions with cell-cycle related proteins of the organotin compound triethyltin(IV)lupinylsulfide hydrochloride. PMID: 11248220 Ref: RPR-115135, a new non peptidomimetic farnesyltransferase inhibitor, induces G0/G1 arrest only in serum starved cells. PMID: 11251185 Ref: Therapeutic vaccines against melanoma and colorectal cancer. PMID: 11257394 Ref: Effect of the nonsteroidal anti-inflammatory drug indomethacin on proliferation and apoptosis of colon carcinoma cells. PMID: 11260862 Ref: Multiple genetic alterations involved in the tumorigenesis of human cholangiocarcinoma: a molecular genetic and clinicopathological study. PMID: 11260864 Ref: Alterations of K-ras and p53 mutations in colorectal cancer patients in Central Europe. PMID: 11261896 Ref: Mutations of p53 gene in human colorectal cancer: distinct frameshifts among populations. PMID: 11275993 Ref: Aberrations of the p53 tumor suppressor gene in various tumors in dogs. PMID: 11277210 Ref: Adenocarcinoma of the colon developing on the basis of Crohn's disease in childhood. PMID: 11277378 Ref: p53-dependent transcriptional regulation of the APC promoter in colon cancer cells treated with DNA alkylating agents. PMID: 11279192 Ref: Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species. PMID: 11280728 Ref: Genetic pathways in the evolution of morphologically distinct colorectal neoplasms. PMID: 11289147 Ref: The results of colorectal cancer treatment by p53 status: treatment-specific overview. PMID: 11289276 Ref: Prognostic significance of K-ras and TP53 mutations in the role of adjuvant chemotherapy on survival in patients with Dukes C colon cancer. PMID: 11289281 Ref: Dukes B colorectal cancer: distinct genetic categories and clinical outcome based on proximal or distal tumor location. PMID: 11289282 Ref: Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer. PMID: 11290569 Ref: p53 Mutations are present in colorectal cancer with cytoplasmic p53 accumulation. PMID: 11291068 Ref: Synergistic effects of dexamethasone and genistein on the expression of Cdk inhibitor p21WAF1/CIP1 in human hepatocellular and colorectal carcinoma cells. PMID: 11295047 Ref: Molecular markers and prediction of response to chemoradiation in rectal cancer. PMID: 11295069 Ref: p53 mutation found to be a significant prognostic indicator in distal colorectal cancer. PMID: 11295071 Ref: Multiple detection of genetic alterations in tumors and stool. PMID: 11297253 Ref: Correlation of immunohistochemical p53 labeling index with inhibition rate in chemosensitivity test in gastric and colon cancer. PMID: 11299739 Ref: Bax protein expression in colorectal cancer: association with p53, bcl-2 and patterns of relapse. PMID: 11299743 Ref: IGF-II down regulation associated cell cycle arrest in colon cancer cells exposed to phenolic antioxidant ellagic acid. PMID: 11299762 Ref: Topoisomerase I-DNA covalent complexes in human colorectal cancer xenografts with different p53 and microsatellite instability status: relation with their sensitivity to CTP-11. PMID: 11299781 Ref: 5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients. PMID: 11300326 Ref: p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2. PMID: 11306450 Ref: Determination of microsatellite instability, p53 and K-RAS mutations in hepatic metastases from patients with colorectal cancer: relationship with response to 5-fluorouracil and survival. PMID: 11307149 Ref: Cell differentiation and chemotherapy influence p53 and Mdm2 immunoreactivity in human HT29 colon cancer cells grown in scid mice. PMID: 11311495 Ref: Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells. PMID: 11313933 Ref: p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells. PMID: 11313989 Ref: A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function. PMID: 11313999 Ref: p53 autoantibodies in sera of patients with a colorectal cancer and their association to p53 protein concentration and p53 immunohistochemistry in tumor tissue. PMID: 11317693 Ref: Prognostic significance of recurrent chromosomal aberrations detected by comparative genomic hybridization in sporadic colorectal cancer. PMID: 11317696 Ref: [Expression of p21 WAF1/CIP1 protein in colorectal cancers: study of its relation to p53 mutation and Ki67 antigen expression]. PMID: 11317955 Ref: Increased levels of insulin-like growth factor binding protein-2 in sera and tumours from patients with colonic neoplasia with and without acromegaly. PMID: 11318786 Ref: Methylation of the hMLH1, p16, and MDR1 genes in colorectal carcinoma: associations with clinicopathological features. PMID: 11323103 Ref: Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition. PMID: 11325813 Ref: Establishment of a Tcrb and Trp53 genes deficient mouse strain as an animal model for spontaneous colorectal cancer. PMID: 11326422 Ref: p73beta, a variant of p73, enhances Wnt/beta-catenin signaling in Saos-2 cells. PMID: 11327702 Ref: Colonic intra-epithelial carcinoma occurring in a hyperplastic polyp via a serrated adenoma. PMID: 11328539 Ref: 8-Cl-adenosine induces differentiation in LS174T cells. PMID: 11330409 Ref: Molecular markers are predictors of recurrence and survival in patients with Dukes B and Dukes C colorectal adenocarcinoma. PMID: 11330579 Ref: The p53-regulated cyclin-dependent kinase inhibitor, p21 (cip1, waf1, sdi1), is not required for global genomic and transcription-coupled nucleotide excision repair of UV-induced DNA photoproducts. PMID: 11331289 Ref: Tumor growth pattern and thymidine phosphorylase expression are related with the risk of hematogenous metastasis in patients with Astler Coller B1/B2 colorectal carcinoma. PMID: 11335901 Ref: Allelic loss of chromosome 2p21-16.3 is associated with reduced survival in sporadic colorectal cancer. PMID: 11336166 Ref: Methylxanthine sensitization of human colon cancer cells to 186Re-labeled monoclonal antibody. PMID: 11337548 Ref: Heterogeneity of DNA methylation status analyzed by bisulfite-PCR-SSCP and correlation with clinico-pathological characteristics in colorectal cancer. PMID: 11341745 Ref: Biomarkers for early detection of colon cancer. PMID: 11350874 Ref: P53 alteration and microsatellite instability have predictive value for survival benefit from chemotherapy in stage III colorectal carcinoma. PMID: 11350904 Ref: Caspase-3 activity as a prognostic factor in colorectal carcinoma. PMID: 11351040 Ref: Immunohistochemical detection of the anti-apoptosis protein, survivin, predicts survival after curative resection of stage II colorectal carcinomas. PMID: 11352303 Ref: P27kip1 expression is associated with tumor response to preoperative chemoradiotherapy in rectal cancer. PMID: 11352304 Ref: Expression of p185 and p53 in benign and malignant colorectal lesions. PMID: 11352401 Ref: Microsatellite instability and the clinicopathological features of sporadic colorectal cancer. PMID: 11358903 Ref: Study of P53 protein expression in colorectal cancer. PMID: 11374803 Ref: Deoxycholic acid suppresses p53 by stimulating proteasome-mediated p53 protein degradation. PMID: 11375905 Ref: Carcinogenesis of cancer of the papilla and ampulla: pathophysiological facts and molecular biological mechanisms. PMID: 11382316 Ref: Frequent p53 mutation in brain (fetal)-type glycogen phosphorylase positive foci adjacent to human 'de novo' colorectal carcinomas. PMID: 11384100 Ref: Hydrocarbon carcinogens evade cellular defense mechanism of G1 arrest in nontransformed and malignant lung cell lines. PMID: 11384212 Ref: Mutations and allelic loss of p53 in primary tumor DNA from potentially cured patients with colorectal carcinoma. PMID: 11387354 Ref: Detecting colorectal cancer in stool with the use of multiple genetic targets. PMID: 11390535 Ref: Expression of survivin correlates with apoptosis, proliferation, and angiogenesis during human colorectal tumorigenesis. PMID: 11391581 Ref: [The role of estrogen receptor, vitamin D receptor and calcium receptor genotypes in the pathogenesis of colorectal cancer]. PMID: 11392075 Ref: Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis. PMID: 11406538 Ref: c-myc/p53 interaction determines sensitivity of human colon carcinoma cells to 5-fluorouracil in vitro and in vivo. PMID: 11406570 Ref: p53, BCL-2, and Ki-67 expression according to tumor response after concurrent chemoradiotherapy for advanced rectal cancer. PMID: 11407516 Ref: Polyamine depletion arrests growth of IEC-6 and Caco-2 cells by different mechanisms. PMID: 11408253 Ref: Loss of p27 expression predicts poor prognosis in patients with Dukes' B stage or proximal colorectal cancer. PMID: 11408921 Ref: [Colorectal carcinoma in Cronkhite-Canada syndrome]. PMID: 11413916 Ref: p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents. PMID: 11423989 Ref: Heterocyclic amine induced apoptotic response in the human lymphoblastoid cell line TK6 is linked to mismatch repair status. PMID: 11425520 Ref: Metabolic radiolabeling: experimental tool or Trojan horse? (35)S-Methionine induces DNA fragmentation and p53-dependent ROS production. PMID: 11427488 Ref: Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses. PMID: 11431359 Ref: Intratumor genetic heterogeneity in advanced human colorectal adenocarcinoma. PMID: 11433398 Ref: K-ras and p53 mutations in colonic lavage fluid of patients with colorectal neoplasias. PMID: 11435722 Ref: Comparative study for histology, proliferative activity, glycoproteins, and p53 protein between old and recent colorectal adenomas in Japan. PMID: 11448534 Ref: P53 codon 72 genotypes in colon cancer. Association with human papillomavirus infection. PMID: 11458982 Ref: Serous tumors of low malignant potential of the ovary-molecular pathology: part 2. PMID: 11469685 Ref: Wild-type p53-function is not required for hyperthermia-enhanced cytotoxicity of cisplatin. PMID: 11471984 Ref: Apoptosis as an independent prognostic indicator in squamous cell carcinoma of the esophagus. PMID: 11472561 Ref: Two metachronous tumors in the radiotherapy fields of a patient with Li-Fraumeni syndrome. PMID: 11474498 Ref: Induction of apoptosis in human colon carcinoma cells HT29 by sublethal cryo-injury: mediation by cytochrome c release. PMID: 11477556 Ref: Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer. PMID: 11484952 Ref: Polymorphisms and colorectal tumor risk. PMID: 11487538 Ref: p53 mutation in plasma DNA and its prognostic value in breast cancer patients. PMID: 11489795 Ref: Serum anti-p53 in relation to mutations across the entire translated p53 gene in colorectal carcinomas. PMID: 11494027 Ref: DNA alkylation-induced phosphorylation of p53 and activation of kinases in colon cancer cells. PMID: 11494044 Ref: Antineoplastic activity of novel N-1-sulfonypyrimidine derivatives. PMID: 11497287 Ref: Replicating adenoviral vector-mediated transfer of a heat-inducible double suicide gene for gene therapy. PMID: 11498759 Ref: Risk of breast and ovarian cancer in women with strong family histories. PMID: 11499690 Ref: Apoptosis and p53 overexpression in human rectal cancer; relationship with response to hyperthermo-chemo-radiotherapy. PMID: 11501834 Ref: The comparison of immunohistochemical proliferation and apoptosis markers in rectal carcinoma treated surgically or by preoperative radio-chemotherapy. PMID: 11505681 Ref: Potential role and chronology of abnormal expression of the Deleted in Colon Cancer (DCC) and the p53 proteins in the development of gastric cancer. PMID: 11518545 Ref: Mutations spanning P53 exons 5-9 detected by non-isotopic RNAse cleavage assay and protein expression in human colon cancer. PMID: 11520564 Ref: Do wine polyphenols modulate p53 gene expression in human cancer cell lines? PMID: 11522280 Ref: The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells. PMID: 11522654 Ref: Apoptosis and cell-cycle regulatory proteins in colorectal carcinoma: relationship to tumour stage and patient survival. PMID: 11523051 Ref: Apoptosis induction by sennoside laxatives in man; escape from a protective mechanism during chronic sennoside use? PMID: 11523059 Ref: Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells. PMID: 11526513 Ref: Immunohistochemical analysis of candidate gene product expression in the duodenal epithelium of children with coeliac sprue. PMID: 11533074 Ref: Cellular protein alterations in colorectal cancer: p28, p53 and p65 studies. PMID: 11534828 Ref: Single alteration of p53 or E-cadherin genes can alter the surgical resection benefit in an experimental model of colon cancer. PMID: 11535849 Ref: p53 nuclear accumulation and multiploidy are adverse prognostic factors in surgically resected stage II colorectal cancers independent of fluorouracil-based adjuvant therapy. PMID: 11554164 Ref: Thymine DNA glycosylase. PMID: 11554300 Ref: Isolation of human antibodies against the central DNA binding domain of p53 from an individual with colorectal cancer using antibody phage display. PMID: 11555596 Ref: DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: role of telomere repeat binding factor 2. PMID: 11556843 Ref: Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse. PMID: 11559569 Ref: Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells. PMID: 11559818 Ref: p53-dependent induction of p21(Cip1/WAF1/Sdi1) protects against oxygen-induced toxicity. PMID: 11568365 Ref: Adenovirus-mediated transfer of the p53 family genes, p73 and p51/p63 induces cell cycle arrest and apoptosis in colorectal cancer cell lines: potential application to gene therapy of colorectal cancer. PMID: 11571580 Ref: Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway. PMID: 11571648 Ref: Genetic markers of survival and liver recurrence after resection of liver metastases from colorectal cancer. PMID: 11571982 Ref: The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax. PMID: 11574543 Ref: Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells. PMID: 11590433 Ref: Mechanisms of oncogenesis in colon versus rectal cancer. PMID: 11592095 Ref: Contrasting molecular pathology of colorectal carcinoma in Egyptian and Western patients. PMID: 11592777 Ref: Frequent allelic imbalance at the ATM locus in DNA multiploid colorectal carcinomas. PMID: 11593417 Ref: Profiling of cancer cells using protein microarrays: discovery of novel radiation-regulated proteins. PMID: 11606398 Ref: Neither p21WAF1 nor 14-3-3sigma prevents G2 progression to mitotic catastrophe in human colon carcinoma cells after DNA damage, but p21WAF1 induces stable G1 arrest in resulting tetraploid cells. PMID: 11606409 Ref: Microsatellite instability, PTEN and p53 germline mutations in glioma families. PMID: 11669337 Ref: Mutagen sensitivity and p53 expression in colorectal cancer in China. PMID: 11677281 Ref: Cloning and chromosomal localization of human WIG-1/PAG608 and demonstration of amplification with increased expression in primary squamous cell carcinoma of the lung. PMID: 11689294 Ref: Short-chain fatty acids inhibit invasive human colon cancer by modulating uPA, TIMP-1, TIMP-2, mutant p53, Bcl-2, Bax, p21 and PCNA protein expression in an in vitro cell culture model. PMID: 11694645 Ref: Identification of two Fas-associated phosphatase-1 (FAP-1) promoters in human cancer cells. PMID: 11696979 Ref: Analysis of the CHK2 gene in lymphoid malignancies. PMID: 11699418 Ref: P21 (WAF1) expression in colorectal cancer: correlation with P53 and cyclin D1 expression, clinicopathological parameters and prognosis. PMID: 11700890 Ref: The investigational new drug XK469 induces G(2)-M cell cycle arrest by p53-dependent and -independent pathways. PMID: 11705845 Ref: Microsatellite instability in thyroid cancer: hot spots, clinicopathological implications, and prognostic significance. PMID: 11705861 Ref: Altered subcellular localization of suppressin, a novel inhibitor of cell-cycle entry, is an independent prognostic factor in colorectal adenocarcinomas. PMID: 11705868 Ref: E2F-1 up-regulates c-Myc and p14(ARF) and induces apoptosis in colon cancer cells. PMID: 11705881 Ref: The potential clinical value of GML and the p53 gene as a predictor of chemosensitivity for colorectal cancer. PMID: 11706756 Ref: Instability of chromosome 17 and the p53 locus in non-familial colorectal cancer with multiple primary malignancies. PMID: 11718221 Ref: O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer. PMID: 11719438 Ref: Intrachromosomal genomic instability in human sporadic colorectal cancer measured by genome-wide allelotyping and inter-(simple sequence repeat) PCR. PMID: 11719460 Ref: Implication of the proliferation and apoptosis associated CSE1L/CAS gene for breast cancer development. PMID: 11724300 Ref: [Alternations of p53 gene, microsatellite instability and proliferation associated antigen Ki-67 in the synchronous multiple colorectal cancers]. PMID: 11729653 Ref: Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis. PMID: 11733361 Ref: Resveratrol induces colon tumor cell apoptosis independently of p53 and precede by epithelial differentiation, mitochondrial proliferation and membrane potential collapse. PMID: 11745454 Ref: Humoral response to p53 in human colorectal tumors: a prospective study of 1,209 patients. PMID: 11745489 Ref: Ki-ras mutation type and the survival benefit from adjuvant chemotherapy in Dukes' C colorectal cancer. PMID: 11745689 Ref: Nuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinoma. PMID: 11747337 Ref: Expression of Id helix-loop-helix proteins in colorectal adenocarcinoma correlates with p53 expression and mitotic index. PMID: 11751402 Ref: Molecular analysis of sulindac-resistant adenomas in familial adenomatous polyposis. PMID: 11751493 Ref: Ubiquitin and malignant transformation of oral mucosa. PMID: 11754502 Ref: Colorectal carcinogenesis. PMID: 11764413 Ref: [Clinical significance of a carcinogenesis model of colorectal carcinoma]. PMID: 11765350 Ref: Genetic alterations in poorly differentiated endocrine colon carcinomas developing in tubulo-villous adenomas: a report of two cases. PMID: 11787850 Ref: p53 gene transfer does not enhance E2F-1-mediated apoptosis in human colon cancer cells. PMID: 11795482 Ref: [The role of p21 (wafl/cip1) in human colorectal carcinoma cell apoptosis]. PMID: 16200730 Ref: Single-Strand Conformation Polymorphism Analysis of Mutations in Exons 4-8 of the TP53 Gene. PMID: 21370130 Ref: Aberrant Crypt Foci in the Background Mucosa of Colorectal Adenocarcinoma. PMID: 26680788 |
Ref: Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. PMID: 11706006 Ref: Nonpeptidomimetic farnesyltransferase inhibitor RPR-115135 increases cytotoxicity of 5-fluorouracil: role of p53. PMID: 11752120 Ref: Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. PMID: 11752408 Ref: Expression of heavy subunit of gamma-glutamylcysteine synthetase (gamma-GCSh) in human colorectal carcinoma. PMID: 11774239 Ref: Mitotic arrest induced by XK469, a novel antitumor agent, is correlated with the inhibition of cyclin B1 ubiquitination. PMID: 11774253 Ref: An insight into the genetic pathway of adenocarcinoma of the small intestine. PMID: 11788563 Ref: Ku86 is essential in human somatic cells. PMID: 11792868 Ref: p53 inhibits adriamycin-induced down-regulation of cyclin D1 expression in human cancer cells. PMID: 11798189 Ref: Molecular staging of colorectal cancer in African-American and Caucasian patients using phenotypic expression of p53, Bcl-2, MUC-1 AND p27(kip-1). PMID: 11802199 Ref: Clinical application of hyperthermia combined with anticancer drugs for the treatment of solid tumors. PMID: 11821791 Ref: The relationship between cyclin B1 overexpression and lymph node metastasis in human colorectal cancer. PMID: 11821797 Ref: Targeted cytotoxic somatostatin analogue AN-238 inhibits somatostatin receptor-positive experimental colon cancers independently of their p53 status. PMID: 11830533 Ref: Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis. PMID: 11836585 Ref: p53 expression in human rectal tissue after radiotherapy: upregulation in normal mucosa versus functional loss in rectal carcinomas. PMID: 11849795 Ref: Coexpression of MUC1 with p53 or MUC2 correlates with lymph node metastasis in colorectal carcinomas. PMID: 11850585 Ref: Comparison of clinicopathologic characteristics and genetic alterations between microsatellite instability-positive and microsatellite instability-negative sporadic colorectal carcinomas in patients younger than 40 years old. PMID: 11852336 Ref: Comparison of microsatellite instability and chromosomal instability in predicting survival of patients with T3N0 colorectal cancer. PMID: 11854698 Ref: Prediction of distant metastases after curative surgery for rectal cancer. PMID: 11855920 Ref: Human papillomavirus type 16 E6-enhanced susceptibility to apoptosis induced by TNF in A2780 human ovarian cancer cell line. PMID: 11857347 Ref: Associations between family history of colorectal cancer and genetic alterations in tumors. PMID: 11857362 Ref: Effect of p53 status on tumor response to antiangiogenic therapy. PMID: 11859195 Ref: Immunohistochemical expression of P53 and oncogenes in ulcerative colitis-associated colorectal carcinoma. PMID: 11865380 Ref: Apoptosis as a cellular predictor for histopathologic response to neoadjuvant radiochemotherapy in patients with rectal cancer. PMID: 11872273 Ref: An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation. PMID: 11875737 Ref: Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin. PMID: 11877436 Ref: Chronic immune activation and inflammation in the pathogenesis of AIDS and cancer. PMID: 11883529 Ref: SN2 DNA-alkylating agent-induced phosphorylation of p53 and activation of p21 gene expression. PMID: 11890931 Ref: Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas. PMID: 11891209 Ref: Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: In vivo activity and mechanisms. PMID: 11894120 Ref: Ceramide involvement in homocamptothecin- and camptothecin-induced cytotoxicity and apoptosis in colon HT29 cells. PMID: 11894136 Ref: Human cells deficient in p53 regulated p21(waf1/cip1) expression exhibit normal nucleotide excision repair of UV-induced DNA damage. PMID: 11895854 Ref: Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases. PMID: 11896073 Ref: Intestinal epithelial lesions associated with signet ring cell carcinoma of the colon and small intestine. PMID: 11902446 Ref: Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: synergism with sulindac-mediated inhibition of Bcl-x(L). PMID: 11912124 Ref: Transcriptional regulation of mitotic genes by camptothecin-induced DNA damage: microarray analysis of dose- and time-dependent effects. PMID: 11912141 Ref: Evaluation of molecular markers in low-grade diffuse astrocytomas: loss of p16 and retinoblastoma protein expression is associated with short survival. PMID: 11914625 Ref: Efficient induction of apoptosis by ONYX-015 adenovirus in human colon cancer cell lines regardless of p53 status. PMID: 11914640 Ref: Investigation of the prognostic and predictive value of thymidylate synthase, p53, and Ki-67 in patients with locally advanced colon cancer. PMID: 11919229 Ref: Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X(L) in addition to Bax and p53 status. PMID: 11920608 Ref: Analysis of key cell-cycle checkpoint proteins in colorectal tumours. PMID: 11920733 Ref: Apoptosis and its correlation with proliferative activity in rectal cancer. PMID: 11920781 Ref: Antitumor effects of miconazole on human colon carcinoma xenografts in nude mice through induction of apoptosis and G0/G1 cell cycle arrest. PMID: 11922774 Ref: TP53 genotype but not p53 immunohistochemical result predicts response to preoperative short-term radiotherapy in rectal cancer. PMID: 11923604 Ref: Differences in the intracellular fate of free and polymer-bound doxorubicin. PMID: 11943391 Ref: New strategies for colorectal cancer prevention and treatment. PMID: 11948369 Ref: [Gene expression significance of beta-catenin, p53 and PCNA in PJS polyposis]. PMID: 11955391 Ref: Prediction of postoperative survival by preoperative serum concentrations of anti-p53 compared to CEA, CA 50, CA 242 and conventional blood tests in patients with colorectal carcinoma. PMID: 11956598 Ref: Neoangiogenesis in colon cancer: correlation between vascular density, vascular endothelial growth factor (VEGF) and p53 protein expression. PMID: 11956638 Ref: The influence of pre-operative radiotherapy on the expression of p53 and adhesion molecules: correlation with treatment results in patients with squamous cell carcinoma or adenocarcinoma. PMID: 11956639 Ref: Microsatellite analysis of fecal DNA for colorectal cancer detection. PMID: 11967905 Ref: mRTVP-1, a novel p53 target gene with proapoptotic activities. PMID: 11971968 Ref: Enhanced expression of vascular endothelial growth factor (VEGF) plays a critical role in the tumor progression potential induced by simian virus 40 large T antigen. PMID: 11973650 Ref: CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability. PMID: 11984524 Ref: Influence of epidermal growth factor receptor (EGFR), p53 and intrinsic MAP kinase pathway status of tumour cells on the antiproliferative effect of ZD1839 ("Iressa"). PMID: 11986789 Ref: Analysis of p53/BAX in primary colorectal carcinoma: low BAX protein expression is a negative prognostic factor in UICC stage III tumors. PMID: 11992551 Ref: Prognostic significance of p53 mutations in colon cancer at the population level. PMID: 11992552 Ref: Induction of p53-specific immune responses in colorectal cancer patients receiving a recombinant ALVAC-p53 candidate vaccine. PMID: 12006514 Ref: Immune recognition of cyclin B1 as a tumor antigen is a result of its overexpression in human tumors that is caused by non-functional p53. PMID: 12009577 Ref: Age-associated loss of heterozygosity of tumor suppressor genes in the gastric mucosa of humans. PMID: 12016117 Ref: Induction of apoptosis by 1,4-phenylenebis(methylene)selenocyanate in cultured human colon cancer cells. PMID: 12017340 Ref: p21, p27, cyclin D1, and p53 in rectal cancer: immunohistology with prognostic significance? PMID: 12018448 Ref: Calcium-sensing receptor A986S polymorphism in human rectal cancer. PMID: 12018449 Ref: Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage. PMID: 12023887 Ref: The p53 stabilizing compound CP-31398 induces apoptosis by activating the intrinsic Bax/mitochondrial/caspase-9 pathway. PMID: 12027451 Ref: Evaluation of the tissue microarray technique for immunohistochemical analysis in rectal cancer. PMID: 12033959 Ref: High apoptotic activity and low epithelial cell proliferation with underexpression of p21(WAF1/CIP1) and p27Kip1 of mucinous carcinomas of the colorectum: comparison with well-differentiated type. PMID: 12047142 Ref: [Etiopathogenic factors in colorectal cancer. Genetic and clinical features (first of 2 parts)]. PMID: 12048974 Ref: Colorectal carcinoma in Poland in 1975 and 1995: not only more, but also different. PMID: 12049310 Ref: Diet activity, and lifestyle associations with p53 mutations in colon tumors. PMID: 12050095 Ref: Colorectal carcinoma with special reference to growth pattern classifications: clinicopathologic characteristics and genetic changes. PMID: 12051534 Ref: Duodenal cancer in a patient with Peutz-Jeghers syndrome: molecular analysis. PMID: 12051537 Ref: Mutation analysis of the CHK2 gene in breast carcinoma and other cancers. PMID: 12052256 Ref: Metallothionein: early marker in the carcinogenesis of ulcerative colitis-associated colorectal carcinoma. PMID: 12053227 Ref: Syndecan-2 mediates adhesion and proliferation of colon carcinoma cells. PMID: 12055189 Ref: RER and LOH association with sporadic colorectal cancer in Taiwanese patients. PMID: 12063967 Ref: Have p53 gene mutations and protein expression a different biological significance in colorectal cancer? PMID: 12064467 Ref: mdm2-p53 Interaction: lack of correlation with the response to 5-fluorouracil in advanced colorectal cancer. PMID: 12065876 Ref: 7-Hydroxystaurosporine (UCN-01) preferentially sensitizes cells with a disrupted TP53 to gamma radiation in lung cancer cell lines. PMID: 12071807 Ref: The prognostic value of invariant chain (Ii) and Her-2/neu expression in curatively resected colorectal cancer. PMID: 12074327 Ref: High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter. PMID: 12082016 Ref: Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis. PMID: 12082630 Ref: Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways. PMID: 12082636 Ref: Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase. PMID: 12084458 Ref: Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. PMID: 12084461 Ref: Genetic and histological assessment of surgical margins in resected liver metastases from colorectal carcinoma: minimum surgical margins for successful resection. PMID: 12093342 Ref: JM216-, JM118-, and cisplatin-induced cytotoxicity in relation to platinum-DNA adduct formation, glutathione levels and p53 status in human tumour cell lines with different sensitivities to cisplatin. PMID: 12093475 Ref: Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer. PMID: 12093899 Ref: [Recent advances in the diagnosis and treatment of colorectal cancers]. PMID: 12094697 Ref: Genetic alterations in normal epithelium of colorectal cancer patients may be a useful indicator for subsequent metachronous tumor development. PMID: 12095975 Ref: Novel colon cancer cell lines leading to better understanding of the diversity of respective primary cancers. PMID: 12096341 Ref: Antigenic and immunologic characterization of an allogeneic colon carcinoma vaccine. PMID: 12100028 Ref: DNA interstrand cross-linking and TP53 status as determinants of tumour cell sensitivity in vitro to the antibody-directed enzyme prodrug therapy ZD2767. PMID: 12110502 Ref: Increased frequency of p53 mutation in sporadic colorectal cancer from cigarette smokers. PMID: 12110635 Ref: Extended lymphadenectomy and preoperative radiotherapy for lower rectal cancers. PMID: 12110792 Ref: Analysis of mutational spectra: locating hotspots and clusters of mutations using recursive segmentation. PMID: 12111894 Ref: RPR-115135, a farnesyltransferase inhibitor, increases 5-FU- cytotoxicity in ten human colon cancer cell lines: role of p53. PMID: 12115540 Ref: Prognostic value of P53 mutations in rectal carcinoma. PMID: 12115559 Ref: Loss of heterozygosity in the clonal evolution of flat colorectal neoplasms. PMID: 12115875 Ref: Immunohistochemical pattern of MLH1/MSH2 expression is related to clinical and pathological features in colorectal adenocarcinomas with microsatellite instability. PMID: 12118112 Ref: Association of p53 mutations, microvessel density and neoangiogenesis in pairs of colorectal cancers and corresponding liver metastases. PMID: 12118317 Ref: P53 mutations in colorectal cancer assessed in both genomic DNA and cDNA as compared to the presence of p53 LOH. PMID: 12118339 Ref: Cancer-related serological recognition of human colon cancer: identification of potential diagnostic and immunotherapeutic targets. PMID: 12124339 Ref: [Immunohistochemistry and genotype analysis of tumors. First part: Which future for the immunochemical diagnosis of cancer?]. PMID: 12124491 Ref: Sebastianines A and B, novel biologically active pyridoacridine alkaloids from the Brazilian ascidian Cystodytes dellechiajei. PMID: 12126446 Ref: Increased endocrine cells in treated rectal adenocarcinomas: a possible reflection of endocrine differentiation in tumor cells induced by chemotherapy and radiotherapy. PMID: 12131153 Ref: Butyrate and aspirin in combination have an enhanced effect on apoptosis in human colorectal cancer cells. PMID: 12131661 Ref: A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF). PMID: 12135761 Ref: Adenovirus-mediated gene transfer of P16INK4/CDKN2 into bax-negative colon cancer cells induces apoptosis and tumor regression in vivo. PMID: 12136424 Ref: Influence of G2 arrest on the cytotoxicity of DNA topoisomerase inhibitors toward human carcinoma cells with different p53 status. PMID: 12136930 Ref: Homogeneous amplification and mutation scanning of the p53 gene using fluorescent melting curves. PMID: 12142390 Ref: Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice. PMID: 12145803 Ref: Anti-tumor efficacy of a novel antisense anti-MDM2 mixed-backbone oligonucleotide in human colon cancer models: p53-dependent and p53-independent mechanisms. PMID: 12149568 Ref: ATM is activated in response to N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA alkylation. PMID: 12151394 Ref: Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio. PMID: 12151395 Ref: Supra-additive antitumor activity of 5FU with tumor necrosis factor-related apoptosis-inducing ligand on gastric and colon cancers in vitro. PMID: 12168112 Ref: Comparative study of various biological parameters, including expression of survivin, between primary and metastatic human colonic adenocarcinomas. PMID: 12168867 Ref: Modulation of the Fas signaling pathway by IFN-gamma in therapy of colon cancer: phase I trial and correlative studies of IFN-gamma, 5-fluorouracil, and leucovorin. PMID: 12171874 Ref: The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein. PMID: 12174820 Ref: Mismatch repair, p53 and beta-catenin proteins in colorectal cancer. PMID: 12174887 Ref: Expression of vascular endothelial growth factor, mitogen-activated protein kinase and p53 in human colorectal cancer. PMID: 12174901 Ref: Efficient repair of bulky anti-BPDE DNA adducts from non-transcribed DNA strand requires functional p53 but not p21(waf1/cip1) and pRb. PMID: 12175902 Ref: Reduced Fhit expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma. PMID: 12177781 Ref: Abrogation of the radiation-induced G2 checkpoint by the staurosporine derivative UCN-01 is associated with radiosensitisation in a subset of colorectal tumour cell lines. PMID: 12177808 Ref: Expression of maspin in colon cancers: its relationship with p53 expression and microvessel density. PMID: 12184537 Ref: GSTM-1 and NAT2 and genetic alterations in colon tumors. PMID: 12195642 Ref: Fighting colorectal cancer: molecular epidemiology differences among Ashkenazi and Sephardic Jews and Palestinians. PMID: 12196377 Ref: Expression of CD10 by stromal cells during colorectal tumor development. PMID: 12203213 Ref: Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status. PMID: 12209584 Ref: Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. PMID: 12221076 Ref: Base excision repair as a therapeutic target in colon cancer. PMID: 12231545 Ref: Antifolates targeting purine synthesis allow entry of tumor cells into S phase regardless of p53 function. PMID: 12234990 Ref: High-frequency microsatellite instability predicts better chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV sporadic colorectal cancer after palliative bowel resection. PMID: 12237891 Ref: Value of expression of p21WAF1/CIP1 as a prognostic factor in advanced middle and lower rectal cancer patients treated with preoperative radio-chemotherapy. PMID: 12239617 Ref: p53 expression and DNA ploidy pattern in Egyptian colorectal carcinoma. PMID: 12239910 Ref: High survivin expression is associated with reduced apoptosis in rectal cancer and may predict disease-free survival after preoperative radiochemotherapy and surgical resection. PMID: 12240548 Ref: p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene. PMID: 12242345 Ref: Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity. PMID: 12244568 Ref: Molecular and genetic toxicology of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). PMID: 12351148 Ref: Loss of p21(WAF1) compartmentalisation in sebaceous carcinoma compared with sebaceous hyperplasia and sebaceous adenoma. PMID: 12354803 Ref: 2-Methoxyestradiol induces p53-associated apoptosis of colorectal cancer cells. PMID: 12359354 Ref: Screening for p53 and K-ras mutations in whole-gut lavage in chronic inflammatory bowel disease. PMID: 12362095 Ref: Frequent RASSF1A tumour suppressor gene promoter methylation in Wilms' tumour and colorectal cancer. PMID: 12370819 Ref: Protein expression of NF-kappaB in human colorectal adenocarcinoma. PMID: 12373289 Ref: Transcriptional activation of the MUC2 gene by p53. PMID: 12374798 Ref: Correlation between malignancy grade and p53 gene in relation to thymidine phosphorylase activity in colorectal cancer patients. PMID: 12375032 Ref: Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells. PMID: 12376477 Ref: [Antitumor vaccines: conception, development and evaluation in humans]. PMID: 12378152 Ref: Less cytotoxicity to combination therapy of 5-fluorouracil and cisplatin than 5-fluorouracil alone in human colon cancer cell lines. PMID: 12378627 Ref: Predominance of CIN versus MSI in the development of rectal cancer at young age. PMID: 12379157 Ref: Benzylamide sulindac analogues induce changes in cell shape, loss of microtubules and G(2)-M arrest in a chronic lymphocytic leukemia (CLL) cell line and apoptosis in primary CLL cells. PMID: 12384529 Ref: UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1. PMID: 12384533 Ref: p53, DCC and thymidylate synthase as predictors of survival after resection of hepatic metastases from colorectal cancer. PMID: 12390383 Ref: [p53 expression and cancer cell invasion in the distal bowel wall of patients with rectal carcinoma]. PMID: 12390734 Ref: [Pathogenesis of colorectal carcinoma]. PMID: 12391909 Ref: Prognostic significance of calcium-binding protein S100A4 in colorectal cancer. PMID: 12404222 Ref: [Genetic pathways in colorectal cancer: interest for the pathologist]. PMID: 12410150 Ref: Molecular validation of the modified Vienna classification of colorectal tumors. PMID: 12411586 Ref: Oligonucleotide microarray data mining: search for age-dependent gene expression. PMID: 12419321 Ref: The role of oxaliplatin in the treatment of advanced metastatic colorectal cancer: prospects and future directions. PMID: 12422306 Ref: DNA markers predicting benefit from adjuvant fluorouracil in patients with colon cancer: a molecular study. PMID: 12423985 Ref: The cyclin-dependent kinase inhibitor butyrolactone is a potent inhibitor of p21 (WAF1/CIP1 expression). PMID: 12429914 Ref: Prognostic values of radiation-induced p53 in adjacent normal mucosa and p21WAF1/CIP1 expression in rectal cancer patients. PMID: 12429971 Ref: No associations of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro polymorphisms with the risk of digestive tract cancers in Japanese. PMID: 12430182 Ref: p53 mutations in L3-loop zinc-binding domain, DNA-ploidy, and S phase fraction are independent prognostic indicators in colorectal cancer: a prospective study with a five-year follow-up. PMID: 12433709 Ref: Low-penetrance genes and their involvement in colorectal cancer susceptibility. PMID: 12433710 Ref: Differential expression of p63 isoforms in normal tissues and neoplastic cells. PMID: 12434410 Ref: Application of the crypt isolation technique to the assessment of genetic alterations of colorectal carcinomas. PMID: 12445134 Ref: Inhibition of tumor growth by S-3-1, a synthetic intermediate of salvianolic acid A. PMID: 12450255 Ref: Topoisomerase I protein expression in primary colorectal cancer and lymph node metastases. PMID: 12454816 Ref: Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner. PMID: 12464677 Ref: Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. PMID: 12466962 Ref: The use of molecular profiling of early colorectal cancer to predict micrometastases. PMID: 12470104 Ref: Tissue microarray molecular profiling of early, node-negative adenocarcinoma of the rectum: a comprehensive analysis. PMID: 12473598 Ref: DNA ploidy and S-phase fraction, but not p53 or NM23-H1 expression, predict outcome in colorectal cancer patients. Result of a 5-year prospective study. PMID: 12474051 Ref: Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction. PMID: 12477050 Ref: Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. PMID: 12481159 Ref: Liver-directed viral therapy for cancer p53-targeted adenoviruses and beyond. PMID: 12487057 Ref: A paradigm for therapy-induced microenvironmental changes in solid tumors leading to drug resistance. PMID: 12492501 Ref: The TP53 codon 72 polymorphism may affect the function of TP53 mutations in breast carcinomas but not in colorectal carcinomas. PMID: 12496062 Ref: Thymidylate synthase and p53 expression in primary tumor do not predict chemotherapy outcome in metastatic colorectal carcinoma. PMID: 12552972 Ref: A novel gene containing PDZ and LIM domains, PCD1, is overexpressed in human colorectal cancer. PMID: 12553053 Ref: Value of p53 protein expression and its relationship with short-term prognosis in colorectal cancer. PMID: 17146270 |
Ref: Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage. PMID: 12427745 Ref: WT1-p53 interactions in insulin-like growth factor-I receptor gene regulation. PMID: 12444079 Ref: Clinical application of oligonucleotide probe array for full-length gene sequencing of TP53 in colon cancer. PMID: 12457032 Ref: Methylation profile of the MLH1 promoter region and their relationship to colorectal carcinogenesis. PMID: 12461746 Ref: Combined deficiency of hMLH1, hMSH2, hMSH3 and hMSH6 is an independent prognostic factor in colorectal cancer. PMID: 12469183 Ref: Genetic pathways of 'de novo' colorectal carcinomas with reference to fetal-type glycogen phosphorylase positive foci. PMID: 12469186 Ref: Apoptosis induced by cryo-injury in human colorectal cancer cells is associated with mitochondrial dysfunction. PMID: 12471619 Ref: Influence of p53 and p21(WAF1) expression on sensitivity of cancer cells to cladribine. PMID: 12473386 Ref: Clinicopathologic characteristics and prognoses of gastric cancer in patients with a positive familial history of cancer. PMID: 12488704 Ref: c-myc down-regulation induces apoptosis in human cancer cell lines exposed to RPR-115135 (C31H29NO4), a non-peptidomimetic farnesyltransferase inhibitor. PMID: 12490573 Ref: Numerical abnormalities of chromosomes 17 and 18 in sporadic colorectal cancer: Incidence and correlation with clinical and biological findings and the prognosis of the disease. PMID: 12500293 Ref: A novel case with germline p53 gene mutation having concurrent multiple primary colon tumours. PMID: 12524418 Ref: Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study. PMID: 12525515 Ref: Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems. PMID: 12529318 Ref: Cancer as an evolutionary process at the cell level: an epidemiological perspective. PMID: 12538342 Ref: Titration of serum p53 antibodies in 1,085 patients with various types of malignant tumors: a multiinstitutional analysis by the Japan p53 Antibody Research Group. PMID: 12548611 Ref: Clinicopathological and molecular biological features of colorectal cancer in patients less than 40 years of age. PMID: 12555297 Ref: Detection of genetic abnormalities in neoplasms from Greek patients with FAP. PMID: 12559075 Ref: Cancer and phase II drug-metabolizing enzymes. PMID: 12570745 Ref: PUMA mediates the apoptotic response to p53 in colorectal cancer cells. PMID: 12574499 Ref: p53, deleted in colorectal cancer gene, and thymidylate synthase as predictors of histopathologic response and survival in low, locally advanced rectal cancer treated with preoperative adjuvant therapy. PMID: 12576893 Ref: Mutated p53 gene encodes a nonmutated epitope recognized by HLA-B*4601-restricted and tumor cell-reactive CTLs at tumor site. PMID: 12591737 Ref: Reconstitution of TGF-beta sensitivity in the VACO-411 human colon carcinoma line by somatic cell fusion with MCF-7. PMID: 12595761 Ref: Dystroglycan expression is frequently reduced in human breast and colon cancers and is associated with tumor progression. PMID: 12598319 Ref: Isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis, induces cell cycle arrest and apoptosis in human colon cancer cells. PMID: 12604687 Ref: Usefulness of liposomes loaded with cytostatic bile acid derivatives to circumvent chemotherapy resistance of enterohepatic tumors. PMID: 12606785 Ref: Genetic tumor markers with prognostic impact in Dukes' stages B and C colorectal cancer patients. PMID: 12610180 Ref: P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53. PMID: 12612901 Ref: p53 protein regulates the effects of amifostine on apoptosis, cell cycle progression, and cytoprotection. PMID: 12618886 Ref: TP53 mutation in colorectal cancer. PMID: 12619112 Ref: Telomeric repeat-length alterations in colorectal carcinoma are associated with loss of heterozygosity and point mutation in p53 gene. PMID: 12632102 Ref: E2F-1 overexpression sensitizes colorectal cancer cells to camptothecin. PMID: 12637937 Ref: Apoptosis induction in human cancer cells by sungucine from Strychnos icaja root. PMID: 12644898 Ref: Correlation of Ki-67, p53, and Adnab-9 immunohistochemical staining and ploidy with clinical and histopathologic features of severely dysplastic colorectal adenomas. PMID: 12645814 Ref: Clinical utility of biochemical markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines. PMID: 12651195 Ref: Putative colon cancer risk factors damage global DNA and TP53 in primary human colon cells isolated from surgical samples. PMID: 12659718 Ref: Transcriptional upregulation of the insulin-like growth factor binding protein IGFBP-3 by sodium butyrate increases IGF-independent apoptosis in human colonic adenoma-derived epithelial cells. PMID: 12663497 Ref: Cigarette smoking and genetic alterations in sporadic colon carcinomas. PMID: 12663519 Ref: Detection of serum p53 protein in patients with different gastrointestinal cancers. PMID: 12670524 Ref: Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells. PMID: 12670866 Ref: p53 and DCC immunohistochemistry in curative rectal cancer surgery. PMID: 12673482 Ref: Molecular targeting and pharmacogenomics in the management of advanced bladder cancer. PMID: 12673700 Ref: Detection of hotspot mutations and polymorphisms using an enhanced PCR-RFLP approach. PMID: 12673796 Ref: Tumour 'budding' and its relationship to p53 and Bcl-2 expression in colorectal cancer. PMID: 12680162 Ref: Induction of colonic epithelial cell apoptosis by p47-dependent oxidants. PMID: 12681507 Ref: [Soft tissue pathologies of the oral cavity]. PMID: 12686915 Ref: Preoperatively irradiated rectal carcinoma: analysis of the histopathologic response and predictive value of proliferating cell nuclear antigen immunostaining. PMID: 12697960 Ref: Oxaliplatin-5-fluorouracil and ionizing radiation. Importance of the sequence and influence of p53 status. PMID: 12697970 Ref: Hypermethylation of the gene promoter and enhancer region can regulate Fas expression and sensitivity in colon carcinoma. PMID: 12700649 Ref: The Drg-1 gene suppresses tumor metastasis in prostate cancer. PMID: 12702552 Ref: Colon carcinogenesis in inflammatory bowel disease: applying molecular genetics to clinical practice. PMID: 12702969 Ref: Coprocytobiology: on the nature of cellular elements from stools in the pathophysiology of colonic disease. PMID: 12702972 Ref: Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers. PMID: 12707038 Ref: Polo-like kinase 1 (PLK1) is overexpressed in primary colorectal cancers. PMID: 12708489 Ref: Usefulness of analysis of p53 alteration and observation of surface microstructure for diagnosis of ulcerative colitis-associated colorectal neoplasia. PMID: 12725330 Ref: A new method for determining the status of p53 in tumor cell lines of different origin. PMID: 12725531 Ref: Colorectal carcinoma nodal staging. Frequency and nature of cytokeratin-positive cells in sentinel and nonsentinel lymph nodes. PMID: 12741889 Ref: The dominant-negative effect of p53 mutants and p21 induction in tetraploid G1 arrest depends on the type of p53 mutation and the nature of the stimulus. PMID: 12742155 Ref: High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine. PMID: 12743811 Ref: Extended operation with or without intraoperative (IORT) and external (EBRT) radiotherapy for gallbladder carcinoma. PMID: 12749210 Ref: Bioluminescent molecular imaging of endogenous and exogenous p53-mediated transcription in vitro and in vivo using an HCT116 human colon carcinoma xenograft model. PMID: 12750563 Ref: Analysis of genetic alterations, classified according to their DNA ploidy pattern, in the progression of colorectal adenomas and early colorectal carcinomas. PMID: 12754737 Ref: Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma. PMID: 12759252 Ref: Genotyping of p53 codon 175 in colorectal cancer. PMID: 12761448 Ref: Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines. PMID: 12763222 Ref: Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) is induced by genistein through the expression of p53 in colorectal cancer cells. PMID: 12767058 Ref: Adenomatous polyposis coli (APC)-independent regulation of beta-catenin degradation via a retinoid X receptor-mediated pathway. PMID: 12771132 Ref: Sensitivity and specificity of a stool DNA multitarget assay panel for the detection of advanced colorectal neoplasia. PMID: 12777192 Ref: Lack of p53 nuclear immunostaining is not indicative of absence of TP53 gene mutations in colorectal adenocarcinomas. PMID: 12777996 Ref: Impact of p53 knockout and topotecan treatment on gene expression profiles in human colon carcinoma cells: a pharmacogenomic study. PMID: 12782583 Ref: [Study of angiogenesis in human colorectal carcinoma and its modulation by p53 and K-ras gene]. PMID: 12783699 Ref: Oncogenic pathway of sporadic colorectal cancer with novel germline missense mutations in the hMSH2 gene. PMID: 12792735 Ref: In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrest. PMID: 12794767 Ref: Mutations in the p53 tumor suppressor gene in colorectal cancer in Taiwan. PMID: 12795343 Ref: Options for screening for colorectal cancer. PMID: 12797674 Ref: Synergistic antitumor effect of TRAIL and doxorubicin on colon cancer cell line SW480. PMID: 12800232 Ref: Tissue microarray technology: validation in colorectal carcinoma and analysis of p53, hMLH1, and hMSH2 immunohistochemical expression. PMID: 12802583 Ref: [Gene-regulating chemoprevention against cancer--as a model for "molecular-targeting prevention" of cancer]. PMID: 12806965 Ref: Poor prognosis of colorectal cancer in patients over 80 years old is associated with down-regulation of tumor suppressor genes. PMID: 12811209 Ref: Abnormal p53 immunohistochemistry is associated with an increased colorectal cancer-related mortality in patients with ulcerative colitis. PMID: 12818291 Ref: Dephosphorylation of p53 during cell death by N-alpha-tosyl-L-phenylalanyl chloromethyl ketone. PMID: 12821135 Ref: RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. PMID: 12821781 Ref: Immunohistochemical analyses of colon cancer in I1307K APC mutation carriers compared with noncarriers. PMID: 12822869 Ref: Enhanced sensitivity to cis-diamminedichloroplatinum(II) of a human carcinoma cell line with mutated p53 gene by cyclin-dependent kinase inhibitor p21(WAF1) expression. PMID: 12824923 Ref: Safety of intravenous administration of a canarypox virus encoding the human wild-type p53 gene in colorectal cancer patients. PMID: 12833131 Ref: Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter. PMID: 12847090 Ref: Sodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK. PMID: 12851702 Ref: Prognostic molecular markers for planning adjuvant chemotherapy trials in Dukes' B colorectal cancer patients: how much evidence is enough? PMID: 12853343 Ref: Antisense Bcl-xl down-regulation switches the response to topoisomerase I inhibition from senescence to apoptosis in colorectal cancer cells, enhancing global cytotoxicity. PMID: 12855666 Ref: p21+/+ (CDKN1A+/+) and p21-/- (CDKN1A-/-) human colorectal carcinoma cells display equivalent amounts of thermal radiosensitization. PMID: 12859231 Ref: Phosphorylation site interdependence of human p53 post-translational modifications in response to stress. PMID: 12860987 Ref: p73 Overexpression and angiogenesis in human colorectal carcinoma. PMID: 12865464 Ref: Nitric oxide suppresses apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions. PMID: 12866025 Ref: Prediction of tumor radiosensitivity in rectal carcinoma based on p53 and Ku70 expression. PMID: 12866572 Ref: Malignancy-associated regions of transcriptional activation: gene expression profiling identifies common chromosomal regions of a recurrent transcriptional activation in human prostate, breast, ovarian, and colon cancers. PMID: 12869305 Ref: Molecular modes of action of artesunate in tumor cell lines. PMID: 12869643 Ref: Intratumoural thymidylate synthase and dihydropyrimidine dehydrogenase activities are good predictors of 5-fluorouracil sensitivity in colorectal cancer. PMID: 12870370 Ref: P53 and beta-catenin in colorectal cancer progression. PMID: 12871177 Ref: Noxa in colorectal cancer: a study on DNA, mRNA and protein expression. PMID: 12879012 Ref: The DNA minor groove-alkylating cyclopropylpyrroloindole drugs adozelesin and bizelesin induce different DNA damage response pathways in human colon carcinoma HCT116 cells. PMID: 12883038 Ref: A Li-Fraumeni syndrome family with retained heterozygosity for a germline TP53 mutation in two tumors. PMID: 12885464 Ref: Dynamic expression profile of p21WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy. PMID: 12885834 Ref: Folic acid mediated attenuation of loss of heterozygosity of DCC tumor suppressor gene in the colonic mucosa of patients with colorectal adenomas. PMID: 12893078 Ref: Identification of 5-fluorouracil-inducible target genes using cDNA microarray profiling. PMID: 12907638 Ref: Human neurotropic polyomavirus, JCV, and its role in carcinogenesis. PMID: 12910255 Ref: [Detection of point mutation in p53 gene by capillary electrophoresis-PCR-SSCP analysis]. PMID: 12910694 Ref: CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer. PMID: 12912934 Ref: Possible alternative carcinogenesis pathway featuring microsatellite instability in colorectal cancer stroma. PMID: 12915883 Ref: [Synergistic effect of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) and doxorubicin on human colon cancer SW480 cells]. PMID: 12917026 Ref: [p53 mutations in sporadic colorectal cancers with microsatellite instability]. PMID: 12921629 Ref: Nitric oxide prevents UV-induced phosphorylation of the p53 tumor-suppressor protein at serine 46: a possible role in inhibition of apoptosis. PMID: 12927814 Ref: Colorectal cancer relapse: allelic alterations associated with tumour marker overexpression. PMID: 12931021 Ref: Potential role of MLH1 in the induction of p53 and apoptosis by blocking transcription on damaged DNA templates. PMID: 12939400 Ref: In situ quantification of aberrant p53 in colorectal neoplasia. PMID: 12944180 Ref: Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53. PMID: 12944906 Ref: Oncocytic adenocarcinoma of the rectum with diffuse intra-luminal microcalcifications: the first reported case. PMID: 12955503 Ref: Clinical significance of Fhit expression in development of colorectal carcinoma of various macroscopic types. PMID: 12964015 Ref: CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene. PMID: 12970742 Ref: Mad2 and p53 expression profiles in colorectal cancer and its clinical significance. PMID: 12970887 Ref: Quantification of p21 gene expression in Caco-2 cells treated with sodium butyrate using real-time reverse transcription-PCR (RT-PCR) assay. PMID: 13678314 Ref: Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53. PMID: 14500353 Ref: Distinct K-ras mutation pattern characterizes signet ring cell colorectal carcinoma. PMID: 14506148 Ref: Magnitude and polarization of P53-specific T-helper immunity in connection to leukocyte infiltration of colorectal tumors. PMID: 14506743 Ref: Repression of IR-inducible clusterin expression by the p53 tumor suppressor protein. PMID: 14508108 Ref: The early response of p53-dependent proteins during radiotherapy in human rectal carcinoma and in adjacent normal tissue. PMID: 14532965 Ref: WNT2 and human gastrointestinal cancer (review). PMID: 14533014 Ref: Clinical significance in molecular detection of p53 mutation in serum of patients with colorectal carcinoma. PMID: 14534722 Ref: Genetic and biochemical changes in colorectal carcinoma in relation to morphologic characteristics. PMID: 14534731 Ref: p53 gene mutations are rare in human papillomavirus-associated colon cancer. PMID: 14534749 Ref: Ferredoxin reductase: pharmacogenomic assessment in colorectal cancer. PMID: 14559799 Ref: Experimental evidence for mutagenic potential of duodenogastric juice on Barrett's esophagus. PMID: 14560365 Ref: EphA2 up-regulation induced by deoxycholic acid in human colon carcinoma cells, an involvement of extracellular signal-regulated kinase and p53-independence. PMID: 14564515 Ref: Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma. PMID: 14568168 Ref: [Immunohistologic evaluation of TS, DPD, and p53 protein expression in patients with colorectal cancer having liver and pulmonary metastases]. PMID: 14574888 Ref: Macrophage inhibitory cytokine-1: a novel biomarker for p53 pathway activation. PMID: 14578467 Ref: Deletions of 17p are associated with transition from early to advanced colorectal cancer. PMID: 14580770 Ref: p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. PMID: 14583449 Ref: Enhanced radiosensitization with gemcitabine in mismatch repair-deficient HCT116 cells. PMID: 14583494 Ref: c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis. PMID: 14583781 Ref: [Prognostic significance and clinic utility of serum and immunohistochemical cathepsin B levels in colorectal cancer]. PMID: 14585038 Ref: Conjugated linoleic acid inhibits cell proliferation through a p53-dependent mechanism: effects on the expression of G1-restriction points in breast and colon cancer cells. PMID: 14608092 Ref: Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells. PMID: 14612511 Ref: Genetic pathways and genome-wide determinants of clinical outcome in colorectal cancer. PMID: 14612515 Ref: Induction of chromosomal instability in colonic cells by the human polyomavirus JC virus. PMID: 14612521 Ref: Recursive partitioning as an approach to selection of immune markers for tumor diagnosis. PMID: 14613989 Ref: Apoptotic response to 5-fluorouracil treatment is mediated by reduced polyamines, non-autocrine Fas ligand and induced tumor necrosis factor receptor 2. PMID: 14614330 Ref: [Relation between p53 expression of human colon cancer cell lines and induction of apoptosis by anticancer drugs]. PMID: 14619538 Ref: Detection of p53 gene mutations by nonisotopic RNase cleavage assay as a predictor of poor prognosis in colorectal cancers. PMID: 14627345 Ref: Analysis of Ki-ras and p53 gene mutations in laterally spreading tumors of the colorectum. PMID: 14629748 Ref: Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway. PMID: 14633673 Ref: Induction of GADD gene expression by phenethylisothiocyanate in human colon adenocarcinoma cells. PMID: 14635187 Ref: Colon cancer-associated DNA mutations: marker selection for the detection of proximal colon cancer. PMID: 14639104 Ref: Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy. PMID: 14645705 Ref: Immunohistochemical and mutational analyses of beta-catenin, Ki-ras, and p53 in two subtypes of colorectal mucinous carcinoma. PMID: 14654549 Ref: Induction of apoptosis by p53, bax, bcl-2, and p21 expressed in colorectal cancer. PMID: 14663636 Ref: Aberrant crypt foci as microscopic precursors of colorectal cancer. PMID: 14669304 Ref: Differential apoptotic response to the proteasome inhibitor Bortezomib [VELCADE, PS-341] in Bax-deficient and p21-deficient colon cancer cells. PMID: 14688479 Ref: Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer. PMID: 14695142 Ref: Interferon-gamma-induced sensitization of colon carcinomas to ZD9331 targets caspases, downstream of Fas, independent of mitochondrial signaling and the inhibitor of apoptosis survivin. PMID: 14695155 Ref: Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin. PMID: 14695196 Ref: Sporadic colorectal cancer in elderly people. PMID: 14696396 Ref: Gene mutations in advanced colonic polyps: potential marker selection for stool-based mutated human DNA assays for colon cancer screening. PMID: 14706178 Ref: Functional and physical interactions between BRCA1 and p53 in transcriptional regulation of the IGF-IR gene. PMID: 14710355 Ref: Genetic analysis of radiation-associated rectal cancer. PMID: 14714259 Ref: [Microsatellite instability and loss of heterozygosity in neoplastic and preneoplastic gastric lesions]. PMID: 14743682 Ref: [Histopathology and tumor markers]. PMID: 14743744 Ref: Anti-P53 antibodies in Brazilian brain tumor patients. PMID: 14966683 Ref: [Effect of learning about the human genome on the development of pathology]. PMID: 14974156 Ref: Fecal multiple molecular tests to detect colorectal cancer in stool. PMID: 15017656 Ref: Bio-pathological factors of prognostic value in colorectal adenocarcinomas. PMID: 16767924 |
Ref: Molecular lesions in colorectal cancer: impact on prognosis? Original data and review of the literature. PMID: 12827409 Ref: Requirement of Kruppel-like factor 4 in preventing entry into mitosis following DNA damage. PMID: 14627709 Ref: Humoral immune response to p53 correlates with clinical course in colorectal cancer patients during adjuvant chemotherapy. PMID: 14634775 Ref: A TP53 polymorphism is associated with increased risk of colorectal cancer and with reduced levels of TP53 mRNA. PMID: 14647431 Ref: 2'-benzoyloxycinnamaldehyde induces apoptosis in human carcinoma via reactive oxygen species. PMID: 14660655 Ref: Regulation of p53 stability and function in HCT116 colon cancer cells. PMID: 14665630 Ref: Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas. PMID: 14688025 Ref: o-Nitrotoluene-induced large intestinal tumors in B6C3F1 mice model human colon cancer in their molecular pathogenesis. PMID: 14688030 Ref: Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation. PMID: 14695993 Ref: Obstructive colitis proximal to partially obstructive colonic carcinoma: a case report and review of the literature. PMID: 14704804 Ref: Clinical and molecular biologic characteristics of early-onset versus late-onset colorectal carcinoma in Filipinos. PMID: 14708047 Ref: Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association. PMID: 14712090 Ref: The destruction box of human Geminin is critical for proliferation and tumor growth in human colon cancer cells. PMID: 14712211 Ref: Regulation of telomerase and its hTERT messenger in colorectal cancer. PMID: 14719074 Ref: Nemo-like kinase suppresses a wide range of transcription factors, including nuclear factor-kappaB. PMID: 14720327 Ref: Quantitative effects on c-Jun N-terminal protein kinase signaling determine synergistic interaction of cisplatin and 17-allylamino-17-demethoxygeldanamycin in colon cancer cell lines. PMID: 14722256 Ref: N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA. PMID: 14728717 Ref: Colorectal cancer without high microsatellite instability and chromosomal instability--an alternative genetic pathway to human colorectal cancer. PMID: 14729584 Ref: A role for p300/CREB binding protein genes in promoting cancer progression in colon cancer cell lines with microsatellite instability. PMID: 14732695 Ref: Intronic deletion affecting a negative regulatory region of TP73 is related to breast and colorectal carcinomas. PMID: 14732927 Ref: Cronkhite-Canada syndrome containing colon cancer and serrated adenoma lesions. PMID: 14755154 Ref: Simultaneous mutations in K-ras and TP53 are indicative of poor prognosis in sporadic colorectal cancer. PMID: 14758132 Ref: Radiosensitization by pan ErbB inhibitor CI-1033 in vitro and in vivo. PMID: 14760092 Ref: Multiple biomarkers of colorectal tumor in a differential diagnosis model: a quantitative study. PMID: 14760775 Ref: Cathepsin D protein levels in colorectal tumors: divergent expression patterns suggest complex regulation and function. PMID: 14767531 Ref: Metastatic tumor doubling time: most important prehepatectomy predictor of survival and nonrecurrence of hepatic colorectal cancer metastasis. PMID: 14961200 Ref: A profile of the in vitro antitumor activity of lissoclinolide. PMID: 14962505 Ref: p53-independent anti-tumor effects of the nitrogen-containing bisphosphonate zoledronic acid. PMID: 14965371 Ref: The replication error phenotype is associated with the development of distant metastases in hormonally treated patients with breast carcinoma. PMID: 14983485 Ref: Enhanced oxaliplatin-induced apoptosis following antisense Bcl-xl down-regulation is p53 and Bax dependent: Genetic evidence for specificity of the antisense effect. PMID: 14985457 Ref: Involvement of Arp2/3 complex in the process of colorectal carcinogenesis. PMID: 14990971 Ref: Identification of Tcf-4 as a transcriptional target of p53 signalling. PMID: 14990988 Ref: A high degree of aneuploidy, loss of p53 gene, and low soluble p53 protein serum levels are detected in ulcerative colitis patients. PMID: 14991492 Ref: Microvessel density, cyclo-oxygenase 2 expression, K-ras mutation and p53 overexpression in colonic cancer. PMID: 14991639 Ref: Nup88 mRNA overexpression is associated with high aggressiveness of breast cancer. PMID: 14999780 Ref: Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line. PMID: 15001986 Ref: Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus. PMID: 15004035 Ref: Expression of p53 protein as a predictor of the response to 5-fluorouracil and cisplatin chemotherapy in human gastrointestinal cancer cell lines evaluated with apoptosis by use of thin layer collagen gel. PMID: 15010816 Ref: Influence of p53 and p21Waf1 expression on G2/M phase arrest of colorectal carcinoma HCT116 cells to proteasome inhibitors. PMID: 15010833 Ref: Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis. PMID: 15010835 Ref: Loss of hMSH2 expression in primary breast cancer with p53 alterations. PMID: 15010883 Ref: Evaluation of genetic mutations of tumor suppresser genes in colorectal cancer patients. PMID: 15011843 Ref: p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis. PMID: 15016801 Ref: Standardized approach for microsatellite instability detection in gastric carcinomas. PMID: 15017590 Ref: Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan. PMID: 15041737 Ref: [Analysis of microsatellite instability and p53 LOH in advanced colorectal cancers--first report of the No. 3 protocol]. PMID: 15045942 Ref: The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe. PMID: 15048074 Ref: Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer. PMID: 15057748 Ref: Immunohistochemical expression of cyclin D1, cyclin E, p21/waf1 and p27/kip1 in inflammatory bowel disease: correlation with other cell-cycle-related proteins (Rb, p53, ki-67 and PCNA) and clinicopathological features. PMID: 15060836 Ref: [Clinical significance of transrectal ultrasound in detecting of rectal cancer margin and deciding of distal surgical incisal edge]. PMID: 15062016 Ref: p53 and HLA class-I expression are not down-regulated in colorectal cancer liver metastases. PMID: 15065606 Ref: Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil. PMID: 15067352 Ref: [Alterations of p53 gene and microsatellite instability in ulcerative colitis and ulcerative colitis-associated colorectal cancer]. PMID: 15067728 Ref: Impact of GSTT1, GSTM1, GSTP1 and NAT2 genotypes on KRAS2 and TP53 gene mutations in colorectal cancer. PMID: 15069679 Ref: beta-Carotene exacerbates DNA oxidative damage and modifies p53-related pathways of cell proliferation and apoptosis in cultured cells exposed to tobacco smoke condensate. PMID: 15073048 Ref: Thirtyfold multiplex genotyping of the p53 gene using solid phase capturable dideoxynucleotides and mass spectrometry. PMID: 15081121 Ref: [Colorectal carcinogenesis: update]. PMID: 15086056 Ref: Correspondence re: M. V. Swamy et al., Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53. Cancer Res 2003;63:5239-42. PMID: 15087416 Ref: Regulation of ultraviolet light-induced gene expression by gene size. PMID: 15087501 Ref: Molecular analysis of astrocytoma associated with Turcot syndrome type 1--case report. PMID: 15095965 Ref: Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors. PMID: 15096505 Ref: [Report of the National Oncology Research and Developement Consortium, 2003]. PMID: 15105900 Ref: The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor. PMID: 15107820 Ref: Allochronic overlapping malignancies after renal transplantation in a patient with p53 gene mutation: report of a case. PMID: 15108094 Ref: Prognostic value of proliferation, apoptosis, defective DNA mismatch repair, and p53 overexpression in patients with resected Dukes' B2 or C colon cancer: a North Central Cancer Treatment Group Study. PMID: 15117979 Ref: Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK. PMID: 15122344 Ref: Time- and dose-dependent effects of curcumin on gene expression in human colon cancer cells. PMID: 15140256 Ref: Different DNA lesions trigger distinct cell death responses in HCT116 colon carcinoma cells. PMID: 15141019 Ref: Correlation of p53 and bcl-2 expression with vascular endothelial growth factor (VEGF), microvessel density (MVD) and clinico-pathological features in colon cancer. PMID: 15142682 Ref: IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines. PMID: 15144569 Ref: The inhibition of tumor growth by triplex-forming oligonucleotides. PMID: 15145520 Ref: Molecular prognostic factors in locally irresectable rectal cancer treated preoperatively by chemo-radiotherapy. PMID: 15154650 Ref: Determination of molecular marker expression can predict clinical outcome in colon carcinomas. PMID: 15161706 Ref: The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites. PMID: 15161716 Ref: Structurally related antitumor effects of flavanones in vitro and in vivo: involvement of caspase 3 activation, p21 gene expression, and reactive oxygen species production. PMID: 15163544 Ref: p53 is an independent pre-treatment markers for long-term survival in stage II and III colorectal cancers: an analysis of interaction between genetic markers and fluorouracil-based adjuvant therapy. PMID: 15172127 Ref: Polyamine biosynthesis in relation to K-ras and p-53 mutations in colorectal carcinoma. PMID: 15180186 Ref: [Genetic aspects of colorectal carcinogenesis]. PMID: 15181754 Ref: Molecular detection of APC, K- ras, and p53 mutations in the serum of colorectal cancer patients as circulating biomarkers. PMID: 15185002 Ref: Evidence for colorectal cancer cell specificity of aspirin effects on NF kappa B signalling and apoptosis. PMID: 15188000 Ref: Tissue preparation for gene expression profiling of colorectal carcinoma: three alternatives to laser microdissection with preamplification. PMID: 15192650 Ref: Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease. PMID: 15199542 Ref: Synthetic bile acid derivatives inhibit cell proliferation and induce apoptosis in HT-29 human colon cancer cells. PMID: 15202011 Ref: Thermal enhancement of oxaliplatin-induced inhibition of cell proliferation and cell cycle progression in human carcinoma cell lines. PMID: 15204521 Ref: Enhanced 7-ethyl-10-hydroxycamptothecin (SN-38) lethality by methylselenocysteine is associated with Chk2 phosphorylation at threonine-68 and down-regulation of Cdc6 expression. PMID: 15213307 Ref: Pathological features and genetic alterations in colorectal carcinomas with characteristics of nonpolypoid growth. PMID: 15213719 Ref: No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer. PMID: 15217503 Ref: Different genetic features associated with colon and rectal carcinogenesis. PMID: 15217933 Ref: Harmonized microarray/mutation scanning analysis of TP53 mutations in undissected colorectal tumors. PMID: 15221790 Ref: Distinct expression patterns of the transcription factor E2F-1 in relation to tumour growth parameters in common human carcinomas. PMID: 15221933 Ref: Reversal of 5-flouroucial resistance by adenovirus-mediated transfer of wild-type p53 gene in multidrug-resistant human colon carcinoma LoVo/5-FU cells. PMID: 15222051 Ref: Reproducibility of a multitarget stool-based DNA assay for colorectal cancer detection. PMID: 15233675 Ref: Expression of vascular endothelial growth factor and receptor flk-1 in colon cancer liver metastases. PMID: 15235888 Ref: Immunoreactivity evaluation of mutant p53 gene product with DNA ploidy pattern in colorectal carcinoma. PMID: 15239234 Ref: DT-diaphorase: a target for new anticancer drugs. PMID: 15245776 Ref: Mitochondrial p53 levels parallel total p53 levels independent of stress response in human colorectal carcinoma and glioblastoma cells. PMID: 15247902 Ref: High sensitivity scanning of colorectal tumors and matched plasma DNA for mutations in APC, TP53, K-RAS, and BRAF genes with a novel DHPLC fluorescence detection platform. PMID: 15251969 Ref: Induction of p53-dependent apoptosis in HCT116 tumor cells by RNA viruses and possible implications in virus-mediated oncolysis. PMID: 15254403 Ref: p53 dependence and apoptosis in response to FP treatment with p53-transfected colon cancer cell lines by use of thin layer collagen gel. PMID: 15254702 Ref: The antitumor triazoloacridone C-1305 is a topoisomerase II poison with unusual properties. PMID: 15258255 Ref: Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO. PMID: 15259066 Ref: Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways. PMID: 15262986 Ref: ATM-dependent CHK2 activation induced by anticancer agent, irofulven. PMID: 15269203 Ref: The breakdown of apoptotic mechanism in the development and progression of colorectal carcinoma. PMID: 15274324 Ref: Alterations of the K-ras and p53 genes and microsatellite instability in sporadic colorectal carcinomas. PMID: 15274399 Ref: Inhibition of proliferation and induction of apoptosis by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide in adult T-cell leukemia cells. PMID: 15276867 Ref: Global investigation of p53-induced apoptosis through quantitative proteomic profiling using comparative amino acid-coded tagging. PMID: 15284338 Ref: Flavone inhibition of tumor growth via apoptosis in vitro and in vivo. PMID: 15289867 Ref: Preliminary evaluation in vitro of the inhibition of cell proliferation, cytotoxicity and induction of apoptosis by 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene. PMID: 15292706 Ref: Antiproliferative effects of ZD0473 (AMD473) in combination with 5-fluorouracil or SN38 in human colorectal cancer cell lines. PMID: 15292710 Ref: Immunohistochemical patterns in rectal cancer: application of tissue microarray with prognostic correlations. PMID: 15300804 Ref: Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. PMID: 15308587 Ref: [The application of p53 gene mutation status in fecal specimen in the diagnosis of colorectal carcinoma]. PMID: 15312403 Ref: Suppression of tumor growth by galectin-7 gene transfer. PMID: 15313906 Ref: Susceptibility to cell death induced by blockade of MAPK pathway in human colorectal cancer cells carrying Ras mutations is dependent on p53 status. PMID: 15325273 Ref: Chk1, but not Chk2, is involved in the cellular response to DNA damaging agents: differential activity in cells expressing or not p53. PMID: 15326376 Ref: Prognostic and predictive molecular markers in colorectal carcinoma. PMID: 15330208 Ref: Oxaliplatin-induced mitochondrial apoptotic response of colon carcinoma cells does not require nuclear DNA. PMID: 15334062 Ref: Distinct secreted Frizzled receptor protein 1 staining pattern in patients with hyperplastic polyposis coli syndrome. PMID: 15335268 Ref: Survivin expression is an independent prognostic factor in rectal cancer patients with and without preoperative radiotherapy. PMID: 15337550 Ref: Reduced levels of the adenomatous polyposis coli (APC) protein are associated with ceramide-induced apoptosis of colon cancer cells. PMID: 15340841 Ref: P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells. PMID: 15342418 Ref: p53 protein accumulation in colorectal cancer tissue has prognostic value only in left-sided colon tumours. PMID: 15350628 Ref: Expression profiling of colorectal carcinomas using tissue microarrays: cell cycle regulatory proteins p21, p27, and p53 as immunohistochemical prognostic markers in univariate and multivariate analysis. PMID: 15354735 Ref: p53 polymorphism and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population. PMID: 15355915 Ref: Molecular differences between RER+ and RER- sporadic endometrial carcinomas in a large population-based series. PMID: 15361209 Ref: Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway. PMID: 15361841 Ref: p53 codon 72 polymorphism and susceptibility malignancy of colorectal cancer in Taiwan. PMID: 15365822 Ref: Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastroph PMID: 15374978 Ref: Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. PMID: 15375533 Ref: Dysfunction of p53 pathway in human colorectal cancer: analysis of p53 gene mutation and the expression of the p53-associated factors p14ARF, p33ING1, p21WAF1 and MDM2. PMID: 15375540 Ref: Construction and expression of a bispecific single-chain antibody that penetrates mutant p53 colon cancer cells and binds p53. PMID: 15375563 Ref: p53 autoantibodies from patients with colorectal cancer recognize common epitopes in the N- or C-terminus of p53. PMID: 15375567 Ref: Biological features of sporadic colorectal carcinoma with high-frequency microsatellite instability: special reference to tumor proliferation and apoptosis. PMID: 15375710 Ref: Allelic imbalance of APAF-1 locus at 12q23 is related to progression of colorectal carcinoma. PMID: 15378005 Ref: Systematic review of genetic influences on the prognosis of colorectal cancer. PMID: 15382104 Ref: Influence of age on adenomatous polyposis coli and p53 mutation frequency in sporadic colorectal cancer-rarity of co-occurrence of mutations in APC, K-ras, and p53 genes. PMID: 15449054 Ref: Mutational analysis of OGG1, MYH, MTH1 in FAP, HNPCC and sporadic colorectal cancer patients: R154H OGG1 polymorphism is associated with sporadic colorectal cancer patients. PMID: 15449173 Ref: Induction of apoptosis by shikonin through coordinative modulation of the Bcl-2 family, p27, and p53, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells. PMID: 15453709 Ref: Sex-specific differences in colon cancer associated with p53 mutations. PMID: 15456634 Ref: Serum p53 antibodies in patients affected with ulcerative colitis. PMID: 15472522 Ref: [Clinical significance of P53-immunohistochemistry in large slice in evaluating distal intramural spread extent in rectal cancer]. PMID: 15473935 Ref: A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines. PMID: 15476557 Ref: Nitric oxide signaling in colon cancer chemoprevention. PMID: 15476855 Ref: Clusterin-mediated apoptosis is regulated by adenomatous polyposis coli and is p21 dependent but p53 independent. PMID: 15492264 Ref: Humoral response to p53 is associated with conserved domains II and IV mutations in human colorectal cancer: a case-control study in Taiwan. PMID: 15492791 Ref: Low-dose radiation hypersensitivity is associated with p53-dependent apoptosis. PMID: 15498930 Ref: APC gene loss of heterozygosity, mutations, E1317Q, and I1307K germ-line variants in sporadic colon cancer in Croatia. PMID: 15507235 Ref: Microsatellite status and cell cycle associated markers in rectal cancer patients undergoing a combined regimen of 5-FU and CPT-11 chemotherapy and radiotherapy. PMID: 15510606 Ref: Equivalence test in quantitative reverse transcription polymerase chain reaction: confirmation of reference genes suitable for normalization. PMID: 15519565 Ref: Effect of pH on radiation-induced p53 expression. PMID: 15519799 Ref: Nitric oxide and ionizing radiation synergistically promote apoptosis and growth inhibition of cancer by activating p53. PMID: 15520210 Ref: [The occurrence and significance of apoptosis in tumors]. PMID: 15520871 Ref: Expression of p27 in residual rectal cancer after preoperative chemoradiation predicts long-term outcome. PMID: 15525823 Ref: Organochlorine exposure and colorectal cancer risk. PMID: 15531428 Ref: Co-mutation of p53, K-ras genes and accumulation of p53 protein and its correlation to clinicopathological features in rectal cancer. PMID: 15534934 Ref: p53 alterations in colon tumors: a comparison of SSCP/sequencing and immunohistochemistry. PMID: 15536342 Ref: Heterogeneity within and between primary colorectal carcinomas and matched metastases as revealed by analysis of Ki-ras and p53 mutations. PMID: 15541358 Ref: Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells. PMID: 15545975 Ref: The clinical implication of 14-3-3 sigma expression in primary gastrointestinal malignancy. PMID: 15547695 Ref: Assessment of K-ras, Smad4 and p53 gene alterations in colorectal metastases and their role in the metastatic process. PMID: 15547741 Ref: Gene expression in response to anti-tumour intervention by polysaccharide-K (PSK) in colorectal carcinoma cells. PMID: 15547752 Ref: Selective loss of codon 72 proline p53 and frequent mutational inactivation of the retained arginine allele in colorectal cancer. PMID: 15548361 Ref: [Expression of HSP70 and P53 in malignant tumor tissues and its relationship to heat syndrome of TCM]. PMID: 15553822 Ref: Genetic alterations in locally advanced stage II/III colon cancer: a search for prognostic markers. PMID: 15555207 Ref: Conjugated docosahexaenoic acid is a potent inducer of cell cycle arrest and apoptosis and inhibits growth of colo 201 human colon cancer cells. PMID: 15572300 Ref: Netrin-1 and its receptors in tumorigenesis. PMID: 15573119 Ref: C-MYB, serum P-53M, genetic instability, labeling index and endoscopic findings in patients with adenoma or colorectal cancer. PMID: 15595638 Ref: Role of the p53/p21 system in the response of human colon carcinoma cells to Doxorubicin. PMID: 15601469 Ref: PKCdelta requires p53 for suppression of the transformed phenotype in human colon cancer cells. PMID: 15601585 Ref: Recombinant cancer vaccines based on viral vectors. PMID: 15603188 Ref: Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1. PMID: 15604277 Ref: Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL. PMID: 15604280 Ref: In vivo recombinant adenovirus-mediated p53 gene therapy in a syngeneic rat model for colorectal cancer. PMID: 15608394 Ref: Prognostic value of p27, p53, and vascular endothelial growth factor in Dukes A and B colon cancer patients undergoing potentially curative surgery. PMID: 15622584 Ref: Evaluation of prognosis for malignant rectal gastrointestinal stromal tumor by clinical parameters and immunohistochemical staining. PMID: 15622586 Ref: Thymidylate synthase expression, p53, bcl-2, Ki-67 and p27 in colorectal cancer: relationships with tumor recurrence and survival. PMID: 15627889 Ref: [Angiogenesis and cancer: from biopathology to therapy]. PMID: 15636732 Ref: Predictive factors of tumor shrinkage and histological regression in patients who received preoperative radiotherapy for rectal cancer. PMID: 15640505 Ref: Apoptosis inducing effects of 6-methoxydihydrosanguinarine in HT29 colon carcinoma cells. PMID: 15646800 Ref: Cyclin E, p27 and mutant p53 do not predict the prognosis in AJCC stage II colorectal carcinomas. PMID: 15665575 Ref: p21Cip/WAF1 activation is an important factor for the ERK pathway dependent anti-proliferation of colorectal cancer cells. PMID: 15665589 Ref: Role of P53 and Bcl-2 in advanced rectal carcinomas treated with adjuvant therapy. PMID: 15675468 Ref: Genetic testing and surgeon decision. PMID: 15771290 Ref: Histopathology of residual rectal carcinoma following preoperative radiochemotherapy. PMID: 15771300 Ref: P53 expression in colorectal carcinoma: the University of Malaya Medical Centre's experience. PMID: 15779585 Ref: Loss of p53 function in colon cancer cells results in increased phosphocholine and total choline. PMID: 15802048 Ref: Responsiveness of CPT-11 in respect to hMLH1 and hMSH2 protein expression in the primary colorectal cancer. PMID: 20368829 Ref: Inheritance of cancer. PMID: 20704938 |
Ref: Influence of thymidylate synthase and p53 protein expression on clinical outcome in patients with colorectal cancer. PMID: 15309465 Ref: Laser pressure catapulting (LPC): optimization LPC-system and genotyping of colorectal carcinomas. PMID: 15316933 Ref: Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracil. PMID: 15365767 Ref: p21(Waf1/Cip1) and p53 are downstream effectors of protein kinase C delta in tumor suppression and differentiation in human colon cancer cells. PMID: 15386430 Ref: Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis. PMID: 15494427 Ref: Genotype phenotype correlations in Israeli colorectal cancer patients. PMID: 15523694 Ref: Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival. PMID: 15532096 Ref: Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells. PMID: 15546879 Ref: 5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. PMID: 15547111 Ref: Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells. PMID: 15560738 Ref: Over-expression of human UREB1 in colorectal cancer: HECT domain of human UREB1 inhibits the activity of tumor suppressor p53 protein. PMID: 15567145 Ref: Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer. PMID: 15574462 Ref: Genetic alteration of p53, but not overexpression of intratumoral p53 protein, or serum p53 antibody is a prognostic factor in sporadic colorectal adenocarcinoma. PMID: 15586226 Ref: Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling. PMID: 15592498 Ref: Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio. PMID: 15596295 Ref: hTERT antagonizes p53-induced apoptosis independently of telomerase activity. PMID: 15608686 Ref: Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis. PMID: 15618392 Ref: Low BAX protein expression correlates with disease recurrence in preoperatively irradiated rectal carcinoma. PMID: 15629598 Ref: Detection of JC virus DNA sequences and expression of viral T antigen and agnoprotein in esophageal carcinoma. PMID: 15630684 Ref: Robust estimation of protein expression ratios with lysate microarray technology. PMID: 15647295 Ref: Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells. PMID: 15655348 Ref: New drugs in cancer therapy, National Tumor Institute, Naples, 17-18 June 2004. PMID: 15655420 Ref: Synergistic antitumor activity of capecitabine in combination with irinotecan. PMID: 15663838 Ref: Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1. PMID: 15665816 Ref: Experimental study of the killing effects of oxymatrine on human colon cancer cell line SW1116. PMID: 15667553 Ref: P53 abnormalities and outcomes in colorectal cancer: a systematic review. PMID: 15668707 Ref: Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner. PMID: 15670751 Ref: Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells. PMID: 15671246 Ref: Loss of heterozygosity: an independent prognostic factor of colorectal cancer. PMID: 15682467 Ref: Low daunomycin concentrations protect colorectal cancer cells from hypoxia-induced apoptosis. PMID: 15688011 Ref: Aberrant methylation of Reprimo in human malignancies. PMID: 15700311 Ref: Mutation analysis of p53, K-ras, and BRAF genes in colorectal cancer progression. PMID: 15702478 Ref: Importance of thymidine phosphorylase expression in tumor stroma as a prognostic factor in patients with advanced colorectal carcinoma. PMID: 15706408 Ref: Induction of apoptosis by R-flurbiprofen in human colon carcinoma cells: involvement of p53. PMID: 15710360 Ref: Support for hMLH1 and MGMT silencing as a mechanism of tumorigenesis in the hyperplastic-adenoma-carcinoma (serrated) carcinogenic pathway in the colon. PMID: 15712188 Ref: Histone deacetylase 1: a target of 9-hydroxystearic acid in the inhibition of cell growth in human colon cancer. PMID: 15716589 Ref: The clinical significance of p53, p21, and p27 expressions in rectal carcinoma. PMID: 15722792 Ref: Investigation of the role of Bax, p21/Waf1 and p53 as determinants of cellular responses in HCT116 colorectal cancer cells exposed to the novel cytotoxic ruthenium(II) organometallic agent, RM175. PMID: 15726367 Ref: 3-Aminomethyl derivatives of 4,11-dihydroxynaphtho[2,3-f]indole-5,10-dione for circumvention of anticancer drug resistance. PMID: 15727877 Ref: A substantial proportion of microsatellite-unstable colon tumors carry TP53 mutations while not showing chromosomal instability. PMID: 15729700 Ref: Evolution of intratumoral genetic heterogeneity during colorectal cancer progression. PMID: 15731168 Ref: Role of bax mutations in apoptosis in colorectal cancers with microsatellite instability. PMID: 15743744 Ref: Aminothiol WR1065 induces differential gene expression in the presence of wild-type p53. PMID: 15750621 Ref: Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors. PMID: 15753391 Ref: Sporadic medullary carcinoma of the colon: a clinicopathologic comparison with nonhereditary poorly differentiated enteric-type adenocarcinoma and neuroendocrine colorectal carcinoma. PMID: 15762280 Ref: Retinoblastoma protein is required for efficient colorectal carcinoma cell apoptosis by histone deacetylase inhibitors in the absence of p21Waf. PMID: 15763542 Ref: Aspirin-induced nuclear translocation of NFkappaB and apoptosis in colorectal cancer is independent of p53 status and DNA mismatch repair proficiency. PMID: 15770215 Ref: Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability. PMID: 15778432 Ref: Effect of indomethacin on cell cycle proteins in colon cancer cell lines. PMID: 15786552 Ref: Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer. PMID: 15788679 Ref: Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families. PMID: 15788729 Ref: Loss of maspin is a helpful prognosticator in colorectal cancer: a tissue microarray analysis. PMID: 15792121 Ref: Kruppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage. PMID: 15806166 Ref: Relationships of tumor inflammatory infiltration and necrosis with microsatellite instability in colorectal cancers. PMID: 15810089 Ref: Variance in the expression of 5-Fluorouracil pathway genes in colorectal cancer. PMID: 15814641 Ref: Correlation between hMLH1/hMSH2 and p53 protein expression in sporadic colorectal cancer. PMID: 15816455 Ref: MnSOD inhibits proline oxidase-induced apoptosis in colorectal cancer cells. PMID: 15817612 Ref: hTERT gene copy number is not associated with hTERT RNA expression or telomerase activity in colorectal cancer. PMID: 15818616 Ref: [Laboratory-immunology indicators according as prognostic factors of patients with colon and rectum cancer]. PMID: 15822675 Ref: Expression of cellular FLICE-inhibitory protein and its association with p53 mutation in colon cancer. PMID: 15832422 Ref: The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma. PMID: 15843421 Ref: The patellazoles inhibit protein synthesis at nanomolar concentrations in human colon tumor cells. PMID: 15846119 Ref: Increased BNip3 and decreased mutant p53 in cisplatin-sensitive PDT-resistant HT29 cells. PMID: 15850808 Ref: Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. PMID: 15855171 Ref: Oncogenic Ras increases sensitivity of colon cancer cells to 5-FU-induced apoptosis. PMID: 15856030 Ref: P53 abnormalities and outcomes in colorectal cancer: a systematic review. PMID: 15856032 Ref: The initiation of colon cancer in a chronic inflammatory setting. PMID: 15860506 Ref: Expression of dihydropyrimidine dehydrogenase, thymidylate synthase, p53 and p21 in metastatic liver tumor from colorectal cancer after 5-fluorouracil-based chemotherapy. PMID: 15865071 Ref: Nanosecond pulsed electric fields (nsPEF) induce direct electric field effects and biological effects on human colon carcinoma cells. PMID: 15869405 Ref: Prognostic evaluation of CD44 expression in correlation with bcl-2 and p53 in colorectal cancer. PMID: 15871560 Ref: Sensitization to UV-induced apoptosis by the histone deacetylase inhibitor trichostatin A (TSA). PMID: 15878336 Ref: Inhibition of colon cancer cell proliferation by the dietary compound conjugated linoleic acid is mediated by the CDK inhibitor p21CIP1/WAF1. PMID: 15880444 Ref: O(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitions. PMID: 15888787 Ref: Bax, a predictive marker for therapeutic response to preoperative chemoradiotherapy in patients with rectal carcinoma. PMID: 15891997 Ref: Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. PMID: 15896711 Ref: Autoimmune response to anti-apoptotic protein survivin and its association with antibodies to p53 and c-myc in cancer detection. PMID: 15896923 Ref: A phase I clinical trial of the sequential combination of irinotecan followed by flavopiridol. PMID: 15897584 Ref: p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target. PMID: 15900046 Ref: Overexpression of CD10 and reduced MUC2 expression correlate with the development and progression of colorectal neoplasms. PMID: 15901128 Ref: Immunohistochemistry of p53, Bcl-2, and Ki-67 as predictors of chemosensitivity. PMID: 15901938 Ref: Molecular mechanisms of econazole-induced toxicity on human colon cancer cells: G0/G1 cell cycle arrest and caspase 8-independent apoptotic signaling pathways. PMID: 15919146 Ref: Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies. PMID: 15923428 Ref: Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal adenocarcinomas: results of a 5-year Gruppo Oncologico dell'Italia Meridionale (GOIM) prospective study. PMID: 15923430 Ref: Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy. PMID: 15929791 Ref: P53 mutation analysis of colorectal liver metastases: relation to actual survival, angiogenic status, and p53 overexpression. PMID: 15930341 Ref: High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for chemotherapeutic strategies. PMID: 15930362 Ref: Adjuvant treatment of colon cancer. PMID: 15933474 Ref: Molecular markers that predict response to colon cancer therapy. PMID: 15934813 Ref: [Study on the prognostic factors of colorectal cancer after radical resection and on suggested model for prediction]. PMID: 15941514 Ref: Effects of p21cip1/waf1 overexpression on growth, apoptosis and differentiation in human colon carcinoma cells. PMID: 15942645 Ref: Synchronous colon and gastric advanced carcinomas. PMID: 15943046 Ref: APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance. PMID: 15943410 Ref: [The first molecular analysis of a Hungarian HNPCC family: a novel MSH2 germline mutation]. PMID: 15945244 Ref: Sulindac activates nuclear translocation of AIF, DFF40 and endonuclease G but not induces oligonucleosomal DNA fragmentation in HT-29 cells. PMID: 15946692 Ref: Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathway. PMID: 15956247 Ref: p53 status and response to radiotherapy in rectal cancer: a prospective multilevel analysis. PMID: 15956964 Ref: Activation of p53-dependent apoptosis by acute ablation of glycogen synthase kinase-3beta in colorectal cancer cells. PMID: 15958644 Ref: Expression of p53, DCC, and HER-2/neu in mucinous carcinoma of the breast. PMID: 15960065 Ref: Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARgamma in human colon cancer Caco-2 cells. PMID: 15961301 Ref: The p53 pathway is synergized by p38 MAPK signaling to mediate 11,11'-dideoxyverticillin-induced G2/M arrest. PMID: 15963507 Ref: Evaluating the combination of molecular prognostic factors in tumor radiosensitivity in rectal cancer. PMID: 15966178 Ref: Hereditary breast cancer syndromes in a Turkish population. Results of molecular germline analysis. PMID: 15993273 Ref: Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated with aneuploidy. PMID: 16007128 Ref: The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer. PMID: 16012945 Ref: Identification of a novel synthetic thiazolidin compound capable of inducing c-Jun NH2-terminal kinase-dependent apoptosis in human colon cancer cells. PMID: 16024641 Ref: Evidence that the p53 negative / Bcl-2 positive phenotype is an independent indicator of good prognosis in colorectal cancer: a tissue microarray study of 460 patients. PMID: 16029489 Ref: Analysis of genetic alterations associated with DNA diploidy, aneuploidy and multiploidy in gastric cancers. PMID: 16037688 Ref: Arg462Gln sequence variation in the prostate-cancer-susceptibility gene RNASEL and age of onset of hereditary non-polyposis colorectal cancer: a case-control study. PMID: 16054567 Ref: A predictive model of rectal tumor response to preoperative radiotherapy using classification and regression tree methods. PMID: 16061859 Ref: A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer. PMID: 16061869 Ref: Mutations in the p53 and Ki-ras genes, microsatellite instability and site of tumor origin in colorectal cancer. PMID: 16077965 Ref: Induction of p21WAF1 expression protects HT29 colon cancer cells from apoptosis induced by cryoinjury. PMID: 16078010 Ref: p53 intronic G13964C variant in colon cancer and its association with HPV. PMID: 16080524 Ref: Correlation of AIB1 overexpression with advanced clinical stage of human colorectal carcinoma. PMID: 16084947 Ref: Cancer-specific gene therapy. PMID: 16096014 Ref: Tumor response to neoadjuvant chemoradiation therapy for rectal adenocarcinoma is mediated by p53-dependent and caspase 8-dependent apoptotic pathways. PMID: 16098252 Ref: Colorectal cancer prognosis: is it all mutation, mutation, mutation? PMID: 16099785 Ref: Signaling through IFN regulatory factor-5 sensitizes p53-deficient tumors to DNA damage-induced apoptosis and cell death. PMID: 16103093 Ref: Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells. PMID: 16107721 Ref: Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients. PMID: 16110022 Ref: Radiation response and cell cycle regulation of p53 rescued malignant keratinocytes. PMID: 16120440 Ref: Non-apoptotic concentrations of prodigiosin (H+/Cl- symporter) inhibit the acidification of lysosomes and induce cell cycle blockage in colon cancer cells. PMID: 16126233 Ref: Novel genetic variations of the p53R2 gene in patients with colorectal adenoma and controls. PMID: 16127747 Ref: Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells. PMID: 16129820 Ref: Induction of polyploidy by histone deacetylase inhibitor: a pathway for antitumor effects. PMID: 16140952 Ref: The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck. PMID: 16141004 Ref: Association of the ERK1/2 and p38 kinase pathways with nitric oxide-induced apoptosis and cell cycle arrest in colon cancer cells. PMID: 16142585 Ref: [Expression and amplification of steroid receptor coactivator-3 gene in colorectal carcinoma and its clinicopathological significance]. PMID: 16149006 Ref: [The molecular screening of the stool for the colorectal carcinoma]. PMID: 16149221 Ref: Who takes the lead in the development of ulcerative colitis-associated colorectal cancers: mutator, suppressor, or methylator pathway? PMID: 16157203 Ref: Enterolactone induces apoptosis and inhibits growth of Colo 201 human colon cancer cells both in vitro and in vivo. PMID: 16158974 Ref: Prognostic value of multimarker analysis in stage III colorectal cancer: one step forward towards an individualized therapy decision. PMID: 16160402 Ref: Adjuvant treatment strategies for early colon cancer. PMID: 16162019 Ref: SMS 201-995 enhances S-phase block induced by 5-fluorouracil in a human colorectal cancer cell line. PMID: 16162975 Ref: Juvenile polyposis coli: a facultative precancerosis with some similarities to ulcerative colitis? PMID: 16164047 Ref: Molecular alterations in tumors and response to combination chemotherapy with gefitinib for advanced colorectal cancer. PMID: 16166444 Ref: The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: influence of tumor site, type of mutation, and adjuvant treatment. PMID: 16172461 Ref: MTHFR variants reduce the risk of G:C->A:T transition mutations within the p53 tumor suppressor gene in colon tumors. PMID: 16177213 Ref: Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells. PMID: 16179498 Ref: JNK1-dependent antimitotic activity of thiazolidin compounds in human non-small-cell lung and colon cancer cells. PMID: 16179969 Ref: Molecular genetic alterations and clinical features in early-onset colorectal carcinomas and their role for the recognition of hereditary cancer syndromes. PMID: 16181381 Ref: The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells. PMID: 16181796 Ref: Is there a role for routine p53 testing in colorectal cancer? PMID: 16186590 Ref: [Radiosensitivity on colorectal neoplasms by recombinant adenoviral-mediated wild-type p53 gene]. PMID: 16194359 Ref: Significance of Cox-2 expression in rectal cancers with or without preoperative radiotherapy. PMID: 16199309 Ref: The p53 codon 72 variation is associated with the age of onset of hereditary non-polyposis colorectal cancer (HNPCC). PMID: 16199549 Ref: Venous invasion and down-regulation of p21(WAF1/CIP1) are associated with metastasis in colorectal carcinomas. PMID: 16201087 Ref: Chemoprevention of colorectal cancer. PMID: 16201746 Ref: p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome. PMID: 16203772 Ref: Overexpressed beta-catenin blocks nitric oxide-induced apoptosis in colonic cancer cells. PMID: 16204024 Ref: Effect of p53 status and STAT1 on chemotherapy-induced, Fas-mediated apoptosis in colorectal cancer. PMID: 16204068 Ref: Pharmacologic modulation of glycogen synthase kinase-3beta promotes p53-dependent apoptosis through a direct Bax-mediated mitochondrial pathway in colorectal cancer cells. PMID: 16204075 Ref: Effect of the farnesyl transferase inhibitor L-744,832 on the colon cancer cell line DLD-1 and its combined use with radiation and 5-FU. PMID: 16224182 Ref: Role of p21waf1/cip1 in effects of oxaliplatin in colorectal cancer cells. PMID: 16227409 Ref: WMC-79, a potent agent against colon cancers, induces apoptosis through a p53-dependent pathway. PMID: 16227412 Ref: P53 and heat shock protein 70 expressions in colorectal adenocarcinoma. PMID: 16228064 Ref: Tumour proliferation, angiogenesis, and ploidy status in human colon cancer. PMID: 16254106 Ref: Microsatellite instability in sporadic and inherited colon adenocarcinomas from Greek patients: correlation with several clinicopathological characteristics. PMID: 16268414 Ref: The role of combined allelic imbalance and mutations of p53 in tumor progression and survival following surgery for colorectal carcinoma. PMID: 16273227 Ref: Differential gene expression of sulindac-treated human breast epithelial cells. PMID: 16273229 Ref: [Testosterone production by tumor tissue in partial androgen deficiency in aged men (PADAM)]. PMID: 16281838 Ref: The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress. PMID: 16288013 Ref: Using a combination of cytochrome P450 1B1 and beta-catenin for early diagnosis and prevention of colorectal cancer. PMID: 16289386 Ref: Modulation of TRAIL-induced tumor cell apoptosis in a hypoxic environment. PMID: 16294025 Ref: Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest. PMID: 16297916 Ref: p53, Bcl-2 and C-Myc expressions in colorectal carcinoma associated with schistosomiasis in Egypt. PMID: 16308474 Ref: [A case of anal fistula cancer probably developing from intraluminal dissemination of rectal cancer]. PMID: 16315938 Ref: A novel logistic model based on clinicopathological features predicts microsatellite instability in colorectal carcinomas. PMID: 16319691 Ref: TP53 mutation and microsatellite instability status for the prediction of survival in adjuvant-treated colon cancer patients. PMID: 16339756 Ref: A new method for isolating colonocytes from naturally evacuated feces and its clinical application to colorectal cancer diagnosis. PMID: 16344060 Ref: Survivin expression in colorectal adenocarcinoma using tissue microarray. PMID: 16353082 Ref: Prognostic significance of bcl-2 and p53 expression in colorectal carcinoma. PMID: 16358373 Ref: Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP. PMID: 16373718 Ref: The proteasome inhibitor bortezomib (Velcade) sensitizes some human tumor cells to Apo2L/TRAIL-mediated apoptosis. PMID: 16382051 Ref: The significance of tumor markers for proliferation and apoptosis in predicting survival in colorectal cancer. PMID: 16400510 Ref: Genetic models of human cancer as a multistep process. Paradigm models of colorectal cancer, breast cancer, and chronic myelogenous and acute lymphoblastic leukaemia. PMID: 16471312 Ref: Immunohistochemical expression of bcl-2 in Dukes' stage B and C colorectal carcinoma patients: correlation with p53 and ki-67 in evaluating prognostic significance. PMID: 16477877 Ref: Thymidylate synthase, thymidine phosphorylase, VEGF and p53 protein expression in primary colorectal cancer for predicting response to 5-fluorouracil-based chemotherapy. PMID: 19956517 |
Ref: Expression of cyclooxygenase-2 in colorectal adenocarcinoma is associated with p53 accumulation and hdm2 overexpression. PMID: 15921850 Ref: Hypoxia, angiogenesis and apoptosis markers in locally advanced rectal cancer. PMID: 16052307 Ref: Biological activities of a recombinant adenovirus p53 (SCH 58500) administered by hepatic arterial infusion in a Phase 1 colorectal cancer trial. PMID: 16082381 Ref: Distinct molecular features of colorectal carcinoma with signet ring cell component and colorectal carcinoma with mucinous component. PMID: 16118624 Ref: Role of the mismatch repair system and p53 in the clastogenicity and cytotoxicity induced by bleomycin. PMID: 16139849 Ref: Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumour growth. PMID: 16170360 Ref: p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1. PMID: 16170570 Ref: Exploring SNP-SNP interactions and colon cancer risk using polymorphism interaction analysis. PMID: 16217767 Ref: Oligonucleotide microarray analysis of distinct gene expression patterns in colorectal cancer tissues harboring BRAF and K-ras mutations. PMID: 16219636 Ref: Relationship between genetic alterations and prognosis in sporadic colorectal cancer. PMID: 16231316 Ref: c-FLIP inhibits chemotherapy-induced colorectal cancer cell death. PMID: 16247474 Ref: Antitumor activity and downregulation of pro-angiogenic molecules in human prostate cancer cells by a novel thiazolidione compound. PMID: 16302260 Ref: Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms. PMID: 16303758 Ref: Influence of TRP53 status on FAS membrane localization, CFLAR (c-FLIP) ubiquitinylation, and sensitivity of GC-2spd (ts) cells to undergo FAS-mediated apoptosis. PMID: 16306425 Ref: Pathological and molecular predictors of the response of rectal cancer to neoadjuvant radiochemotherapy. PMID: 16324817 Ref: Angiogenesis and p53 at the invading tumor edge: prognostic markers for colorectal cancer beyond stage. PMID: 16325858 Ref: An overview of apoptosis and the prevention of colorectal cancer. PMID: 16326109 Ref: Methylation-induced silencing of ASC and the effect of expressed ASC on p53-mediated chemosensitivity in colorectal cancer. PMID: 16331272 Ref: Dexamethasone desensitizes hepatocellular and colorectal tumours toward cytotoxic therapy. PMID: 16338063 Ref: Detection of stool DNA mutations before and after treatment of colorectal neoplasia. PMID: 16342248 Ref: Anticancer activity of the lanthanum compound [tris(1,10-phenanthroline)lanthanum(III)]trithiocyanate (KP772; FFC24). PMID: 16343446 Ref: Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cells. PMID: 16344270 Ref: Epithelial and stromal genetic instability contributes to genesis of colorectal adenomas. PMID: 16354798 Ref: Expression of sFRP-4 and beta-catenin in human colorectal carcinoma. PMID: 16356838 Ref: Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay. PMID: 16369045 Ref: T-cell response to p53 tumor-associated antigen in patients with colorectal carcinoma. PMID: 16391798 Ref: The interaction between two radiosensitizers: 5-iododeoxyuridine and caffeine. PMID: 16397265 Ref: Tumor-specific hyperactive low-molecular-weight cyclin E isoforms detection and characterization in non-metastatic colorectal tumors. PMID: 16397408 Ref: Prevalence of early onset colorectal cancer in 397 patients with classic Li-Fraumeni syndrome. PMID: 16401470 Ref: BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status. PMID: 16403224 Ref: The human pre-B cell line Nalm-6 is highly proficient in gene targeting by homologous recombination. PMID: 16405397 Ref: p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine. PMID: 16407843 Ref: Silencing of DMBT1 in neuroblastoma cell lines is not due to methylation of CCWGG motifs on its promoter. PMID: 16416007 Ref: P53 correlates positively with VEGF in preoperative sera of colorectal cancer patients. PMID: 16416012 Ref: Genetic detection of lymph node micrometastases: a selection criterion for liver transplantation in patients with liver metastases after colorectal cancer. PMID: 16421478 Ref: Decrease in c-Myc activity enhances cancer cell sensitivity to vinblastine. PMID: 16428936 Ref: Anticancer activities of novel chalcone and bis-chalcone derivatives. PMID: 16434201 Ref: Ionizing radiation enhances the expression of the nonsteroidal anti-inflammatory drug-activated gene (NAG1) by increasing the expression of TP53 in human colon cancer cells. PMID: 16435911 Ref: DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosis. PMID: 16446370 Ref: Polymorphisms in insulin-related genes predispose to specific KRAS2 and TP53 mutations in colon cancer. PMID: 16448675 Ref: Mismatch repair, p53 and chromosomal aberrations in primary colorectal carcinomas. PMID: 16464797 Ref: Loss of heterozygosity in human aberrant crypt foci (ACF), a putative precursor of colon cancer. PMID: 16474178 Ref: Repression of HIP/RPL29 expression induces differentiation in colon cancer cells. PMID: 16475173 Ref: Aberrant crypt foci. PMID: 16475686 Ref: The prognostic impact of O6-Methylguanine-DNA Methyltransferase (MGMT) promotor hypermethylation in esophageal adenocarcinoma. PMID: 16477636 Ref: Association between MDM2-SNP309 and age at colorectal cancer diagnosis according to p53 mutation status. PMID: 16478747 Ref: Analysis of neuroendocrine differentiation and the p53/BAX pathway in UICC stage III colorectal carcinoma identifies patients with good prognosis. PMID: 16485142 Ref: Profiling markers of prognosis in colorectal cancer. PMID: 16489072 Ref: PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States). PMID: 16489531 Ref: Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae. PMID: 16500682 Ref: c-Abl-independent p73 stabilization during gemcitabine- or 4'-thio-beta-D-arabinofuranosylcytosine-induced apoptosis in wild-type and p53-null colorectal cancer cells. PMID: 16505115 Ref: p53 is involved in clearance of ionizing radiation-induced RAD51 foci in a human colon cancer cell line. PMID: 16516153 Ref: Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop. PMID: 16518869 Ref: Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study. PMID: 16524972 Ref: The antitumor effect of a novel differentiation inducer, 2, 2-Bis (4-(4-amino-3-hydroxyphenoxy) phenyl) adamantane (DPA), in combinatory therapy on human colon cancer. PMID: 16525652 Ref: Mutational targets in colorectal cancer cells with microsatellite instability. PMID: 16528606 Ref: Colorectal carcinoma from Saudi Arabia. Analysis of MLH-1, MSH-2 and p53 genes by immunohistochemistry and tissue microarray analysis. PMID: 16532091 Ref: Telomere dysfunction and loss of p53 cooperate in defective mitotic segregation of chromosomes in cancer cells. PMID: 16547498 Ref: Evaluation of p53 codon 72 polymorphism in adenocarcinomas of the colon and rectum in La Plata, Argentina. PMID: 16552814 Ref: Microsatellite instability in colorectal cancer. PMID: 16555243 Ref: VEGF expression in the colorectal adenoma-carcinoma sequence. PMID: 16555551 Ref: [Comparison of geno- and cytotoxicity of methylnitrosourea on MMR-proficient and MMR-deficient human tumor cell lines]. PMID: 16568831 Ref: Using p53-immunostained large specimens to determine the distal intramural spread margin of rectal cancer. PMID: 16570359 Ref: Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway. PMID: 16574813 Ref: Immunohistochemical expression of p16, p53, and p63 in colorectal adenomas and adenocarcinomas. PMID: 16575619 Ref: Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. PMID: 16584549 Ref: Mitosis-independent survivin gene expression in vivo and regulation by p53. PMID: 16585159 Ref: Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex changes and multiple forms of chromosomal instability in colorectal cancers. PMID: 16585170 Ref: The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells. PMID: 16585172 Ref: Comparative integromics on Ephrin family. PMID: 16596216 Ref: Acyclic retinoid, a novel synthetic retinoid, induces growth inhibition, apoptosis, and changes in mRNA expression of cell cycle- and differentiation-related molecules in human colon carcinoma cells. PMID: 16596235 Ref: [The expression of mutation p53 gene from circulating cancer cells of peripheral blood and the clinical significance in detecting the patients with colorectal cancer]. PMID: 16604493 Ref: Fish detected p53 deletion and N-MYC amplification in colorectal cancer. PMID: 16608022 Ref: Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer. PMID: 16609010 Ref: Relationship between somatostatin receptor subtype expression and clinicopathology, Ki-67, Bcl-2 and p53 in colorectal cancer. PMID: 16610049 Ref: Inflammation and cancer: the role of the immune response and angiogenesis. PMID: 16610701 Ref: Prognostic significance of epidermal growth factor receptor expression in colon cancer patients undergoing curative surgery. PMID: 16614884 Ref: Discovery and evaluation of dual CDK1 and CDK2 inhibitors. PMID: 16618755 Ref: Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling. PMID: 16619034 Ref: hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway. PMID: 16619047 Ref: Methylation and repeats in silent and nonsense mutations of p53. PMID: 16620878 Ref: Selenomethionine induces p53 mediated cell cycle arrest and apoptosis in human colon cancer cells. PMID: 16627976 Ref: Adenovirus-mediated transfer of siRNA against PTTG1 inhibits liver cancer cell growth in vitro and in vivo. PMID: 16628636 Ref: Synthesis and structure-activity relationship studies of 4,11-diaminonaphtho[2,3-f]indole-5,10-diones. PMID: 16631372 Ref: O6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States). PMID: 16633920 Ref: Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas. PMID: 16645205 Ref: Clinicopathological characteristics, microsatellite instability, and expression of mucin core proteins and p53 in colorectal mucinous adenocarcinomas in relation to location. PMID: 16645863 Ref: Methoxyamine potentiates iododeoxyuridine-induced radiosensitization by altering cell cycle kinetics and enhancing senescence. PMID: 16648559 Ref: Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation. PMID: 16651407 Ref: Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. PMID: 16652156 Ref: Prognostic value of p16INK4a and p14ARF gene hypermethylation in human colon cancer. PMID: 16675157 Ref: Thymidylate synthase expression in colon carcinomas with microsatellite instability. PMID: 16675565 Ref: Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB. PMID: 16682957 Ref: Genetic dissection of apoptosis and cell cycle control in response of colorectal cancer treated with preoperative radiochemotherapy. PMID: 16686938 Ref: [Role of the genetic polymorphism of p53 (codon 72) gene in colorectal cancer]. PMID: 16699611 Ref: Expression of the p53 protein and clinical and pathologic correlation in adenocarcinoma of the rectum. PMID: 16699612 Ref: Octahedral Pt(IV) complex K101 induces apoptosis via ERK1/2 activation and the p53 pathway in human colon cancer cells. PMID: 16702812 Ref: Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. PMID: 16707462 Ref: KRAS(D13) Promotes apoptosis of human colorectal tumor cells by ReovirusT3D and oxaliplatin but not by tumor necrosis factor-related apoptosis-inducing ligand. PMID: 16707468 Ref: Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. PMID: 16709241 Ref: [Cyclo-oxygenase-2 and p53 immunoreactivity in superficial early colorectal carcinoma]. PMID: 16714876 Ref: Microdissection-based allelotyping: a novel technique to determine the temporal sequence and biological aggressiveness of colorectal cancer. PMID: 16719202 Ref: Implications of CEA and p53 overexpression in the poor prognosis of colorectal cancer. PMID: 16720924 Ref: Questioning the oncogenic role of DeltaNp73alpha in different cell lines expressing p53 or not. PMID: 16721041 Ref: Different p53 mutation patterns in colorectal tumors from smokers and nonsmokers. PMID: 16721749 Ref: p53 Arg72Pro polymorphism and risk of colorectal adenoma and cancer. PMID: 16721787 Ref: Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent manner. PMID: 16728583 Ref: DNA mismatch repair and p53 function are major determinants of the rate of development of cisplatin resistance. PMID: 16731756 Ref: Quantitative analysis of the level of p53 and p21(WAF1) mRNA in human colon cancer HT-29 cells treated with inositol hexaphosphate. PMID: 16733561 Ref: Scoring of p53, VEGF, Bcl-2 and APAF-1 immunohistochemistry and interobserver reliability in colorectal cancer. PMID: 16741523 Ref: Inter-relationship between microsatellite instability, thymidylate synthase expression, and p53 status in colorectal cancer: implications for chemoresistance. PMID: 16753067 Ref: Novel P53 mutations detected by FAMA in colorectal cancers. PMID: 16760300 Ref: Molecular detection of TP53, Ki-Ras and p16INK4A promoter methylation in plasma of patients with colorectal cancer and its association with prognosis. Results of a 3-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study. PMID: 16760301 Ref: Cancer surveillance in inflammatory bowel disease: new molecular approaches. PMID: 16760754 Ref: Elevated microsatellite instability at selected tetranucleotide repeats does not correlate with clinicopathologic features of bladder cancer. PMID: 16762487 Ref: HCCR-1-interacting molecule "deleted in polyposis 1" plays a tumor-suppressor role in colon carcinogenesis. PMID: 16762630 Ref: Thioredoxin reductase is required for the inactivation of tumor suppressor p53 and for apoptosis induced by endogenous electrophiles. PMID: 16777982 Ref: Acetyl-keto-beta-boswellic acid inhibits cellular proliferation through a p21-dependent pathway in colon cancer cells. PMID: 16783403 Ref: Invasive colorectal micropapillary carcinoma: an aggressive variant of adenocarcinoma. PMID: 16784979 Ref: Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. PMID: 16797627 Ref: Beta-escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21(waf1/cip1) in colon cancer cells. PMID: 16818504 Ref: Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 16820091 Ref: Inflammatory infiltration, fibrosis, necrosis and mucinous content in relation to clinicopathological and molecular factors in rectal cancers with or without preoperative radiotherapy. PMID: 16820910 Ref: Differential expression of Bcl-2, Bcl-XL and p53 in colorectal cancer. PMID: 16824061 Ref: Synthetic small interfering RNA targeting heat shock protein 105 induces apoptosis of various cancer cells both in vitro and in vivo. PMID: 16827803 Ref: Influence of the c-erb B-2, nm23, bcl-2 and p53 protein markers on colorectal cancer. PMID: 16830272 Ref: Effects of inositol hexaphosphate on proliferation of HT-29 human colon carcinoma cell line. PMID: 16830361 Ref: Apoptotic effects of over-expressed estrogen receptor-beta on LoVo colon cancer cell is mediated by p53 signalings in a ligand-dependent manner. PMID: 16830793 Ref: Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts. PMID: 16835297 Ref: Multiplex sequencing of paired-end ditags (MS-PET): a strategy for the ultra-high-throughput analysis of transcriptomes and genomes. PMID: 16840528 Ref: Uranyl nitrilotriacetate, a stabilized salt of uranium, is genotoxic in nontransformed human colon cells and in the human colon adenoma cell line LT97. PMID: 16840563 Ref: Bak functionally complements for loss of Bax during p14ARF-induced mitochondrial apoptosis in human cancer cells. PMID: 16847458 Ref: Down-regulation of p21 (CDKN1A/CIP1) is inversely associated with microsatellite instability and CpG island methylator phenotype (CIMP) in colorectal cancer. PMID: 16850502 Ref: Prognostic significance of histological features and biological parameters in stage I (pT1 and pT2) colorectal adenocarcinoma. PMID: 16860493 Ref: p21(Cip1/Waf1/Sdi1) protects against hyperoxia by maintaining expression of Bcl-X(L). PMID: 16863993 Ref: New p53 related genes in human tumors: significant downregulation in colon and lung carcinomas. PMID: 16865262 Ref: Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a 'fusion' pathway to colorectal cancer. PMID: 16879389 Ref: Radiosensitization of colorectal carcinoma cell lines by histone deacetylase inhibition. PMID: 16887021 Ref: Relationship between point gene mutation, chromosomal abnormality, and tumour suppressor gene methylation status in colorectal adenomas. PMID: 16902913 Ref: Phenotype-genotype correlation: challenge of intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. PMID: 16906516 Ref: Colorectal mucinous adenocarcinoma: the clinicopathologic features and significance of p16 and p53 expression. PMID: 16912910 Ref: Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers. PMID: 16918136 Ref: Heterogeneous microsatellite instability observed within epithelium of ulcerative colitis. PMID: 16929496 Ref: Circumvention and reactivation of the p53 oncogene checkpoint in mouse colon tumors. PMID: 16949053 Ref: Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers. PMID: 16951157 Ref: Prognostic impact of microsatellite instability and DNA ploidy in human colon carcinoma patients. PMID: 16952542 Ref: Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer. PMID: 16953238 Ref: Sessile serrated adenomas of the large bowel. Clinicopathologic and immunohistochemical study including comparison with common hyperplastic polyps and adenomas. PMID: 16955561 Ref: Transcriptional activation of the carboxylesterase 2 gene by the p53 pathway. PMID: 16963839 Ref: Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer. PMID: 16969349 Ref: A prospective, blinded analysis of thymidylate synthase and p53 expression as prognostic markers in the adjuvant treatment of colorectal cancer. PMID: 16971666 Ref: KRAS, p53 and BRAF gene mutations and aneuploidy in sporadic colorectal cancer progression. PMID: 16988471 Ref: ECA39 is a novel distant metastasis-related biomarker in colorectal cancer. PMID: 17007058 Ref: Ursodeoxycholic acid modulates histone acetylation and induces differentiation and senescence. PMID: 17019713 Ref: Correlation of microsatellite status, proliferation, apoptotic and selected immunohistochemical markers in colorectal carcinoma studied with tissue microarray. PMID: 17019973 Ref: Microsatellite instability accounts for tumor site-related differences in clinicopathologic variables and prognosis in human colon cancers. PMID: 17026563 Ref: The presence of an intronic deletion in p73 and high levels of ZEB1 alter the TAp73/DeltaTAp73 ratio in colorectal carcinomas. PMID: 17029218 Ref: Genetic instability on chromosome 17 in the epithelium of non-polypoid colorectal carcinomas compared to polypoid lesions. PMID: 17032312 Ref: Quantitative analysis of the expression of p53 gene in colorectal carcinoma by using real-time PCR. PMID: 17041552 Ref: Regulating p73 isoforms in human tumours. PMID: 17044134 Ref: Opposing securin and p53 protein expression in the oxaliplatin-induced cytotoxicity of human colorectal cancer cells. PMID: 17045763 Ref: Global DNA and p53 region-specific hypomethylation in human colonic cells is induced by folate depletion and reversed by folate supplementation. PMID: 17056795 Ref: ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer. PMID: 17060676 Ref: The DNA damage checkpoint is activated during residual tumour cell survival to methotrexate treatment as an initial step of acquired drug resistance. PMID: 17075316 Ref: Improved marker combination for detection of de novo genetic variation and aberrant DNA in colorectal neoplasia. PMID: 17082247 Ref: (2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells. PMID: 17083937 Ref: Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. PMID: 17090686 Ref: [Influence and significance of preoperative intraarterial infusion chemotherapy combined with radiotherapy on survivin, p53 and Bax expression in low rectal carcinoma]. PMID: 17094914 Ref: Colon cancer and gene alterations: their immunological implications and suggestions for prognostic indices and improvements in biotherapy. PMID: 17105421 Ref: [Pancreatic cancer]. PMID: 17111879 Ref: p53 Gene mutations in sporadic colorectal carcinoma in Guangxi region. PMID: 17118779 Ref: Loss of p27 expression and microsatellite instability in sporadic colorectal cancer. PMID: 17123889 Ref: NSAID activated gene (NAG-1), a modulator of tumorigenesis. PMID: 17129398 Ref: Mechanisms of genotoxin-induced transcription and hypermutation in p53. PMID: 17140443 Ref: Effect of ligand troglitazone on peroxisome proliferator-activated receptor gamma expression and cellular growth in human colon cancer cells. PMID: 17143939 Ref: [Small-cell rectal carcinoma coexisted with tubular-villous adenoma]. PMID: 17144530 Ref: p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation. PMID: 17145870 Ref: Promoter methylation precedes chromosomal alterations in colorectal cancer development. PMID: 17167178 Ref: Modulation of the cell cycle and induction of apoptosis in human cancer cells by synthetic bile acids. PMID: 17168673 Ref: Gypenosides induced apoptosis in human colon cancer cells through the mitochondria-dependent pathways and activation of caspase-3. PMID: 17201150 Ref: Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ROS, Ca2+ and the activation of caspase-3. PMID: 17201158 Ref: Immunohistochemical expression of bcl-2 in UICC stage I and III colorectal carcinoma patients: correlation with c-erbB-2, p53, ki-67, CD44, laminin and collagen IV in evaluating prognostic significance. PMID: 17219742 Ref: Uptake of anti-anemic substance ferric-sorbitol-citrate by normal and malignant cells and its effects on expression of transferrin receptor 1 and ferritin. PMID: 17257079 Ref: Early genetic instability of both epithelial and stromal cells in esophageal squamous cell carcinomas, contrasted with Barrett's adenocarcinomas. PMID: 17287898 Ref: p53 and p27 as predictors of clinical outcome for rectal-cancer patients receiving neoadjuvant therapy. PMID: 17360176 Ref: Increased risk of colorectal adenomas in Italian subjects carrying the p53 PIN3 A2-Pro72 haplotype. PMID: 17374954 Ref: Selective resistance of tetraploid cancer cells against DNA damage-induced apoptosis. PMID: 17384245 Ref: Fatty acid synthase hyperactivation in human colorectal cancer: relationship with tumor side and sex. PMID: 17687193 Ref: Types of colorectal adenoma. PMID: 17867575 Ref: Prognostic Values of microRNAs in Colorectal Cancer. PMID: 18079988 Ref: Non-coding MicroRNAs hsa-let-7g and hsa-miR-181b are Associated with Chemoresponse to S-1 in Colon Cancer. PMID: 18172508 |
Ref: Antiproliferative activity and induction of apoptosis in human colon cancer cells treated in vitro with constituents of a product derived from Pistacia lentiscus L. var. chia. PMID: 16713222 Ref: Frequent occurrence of uniparental disomy in colorectal cancer. PMID: 16774939 Ref: Colorectal cancer in a population with endemic Schistosoma mansoni: is this an at-risk population? PMID: 16786317 Ref: Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells. PMID: 16825434 Ref: Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin. PMID: 16901994 Ref: Hypoxia induces p53-dependent transactivation and Fas/CD95-dependent apoptosis. PMID: 16917513 Ref: Distinct molecular patterns based on proximal and distal sporadic colorectal cancer: arguments for different mechanisms in the tumorigenesis. PMID: 17021745 Ref: Different matrix micro-environments in colon cancer and diverticular disease. PMID: 17021746 Ref: p53 protein accumulation as a prognostic marker in sporadic colorectal cancer. PMID: 17021749 Ref: Inhibition of Fas expression by RNAi modulates 5-fluorouracil-induced apoptosis in HCT116 cells expressing wild-type p53. PMID: 17056233 Ref: Synchronous adenocarcinomas of intestinal type of the inner nose and the colon. PMID: 17084438 Ref: An integrated map of p53-binding sites and histone modification in the human ENCODE regions. PMID: 17085012 Ref: Loss of nuclear p27 (CDKN1B/KIP1) in colorectal cancer is correlated with microsatellite instability and CIMP. PMID: 17086168 Ref: In vivo evaluation of the role of DNp73alpha protein in regulating the p53-dependent apoptotic pathway after treatment with cytotoxic drugs. PMID: 17096333 Ref: Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion. PMID: 17130833 Ref: Protoporphyrin IX interacts with wild-type p53 protein in vitro and induces cell death of human colon cancer cells in a p53-dependent and -independent manner. PMID: 17135250 Ref: Expression of MAC30 protein is related to survival and biological variables in primary and metastatic colorectal cancers. PMID: 17143516 Ref: Prognostic value of cell cycle and apoptosis regulatory proteins in mismatch repair-proficient colorectal cancer: a tissue microarray-based approach. PMID: 17145638 Ref: RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. PMID: 17146433 Ref: Ferric iron is genotoxic in non-transformed and preneoplastic human colon cells. PMID: 17157427 Ref: Colorectal cancer: potential therapeutic benefits of Vitamin D. PMID: 17157547 Ref: Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells. PMID: 17182797 Ref: Alterations in cell proliferation and apoptosis in colon cancers with microsatellite instability. PMID: 17187355 Ref: Eukaryotic translation initiation factor 5A induces apoptosis in colon cancer cells and associates with the nucleus in response to tumour necrosis factor alpha signalling. PMID: 17187778 Ref: Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress. PMID: 17188250 Ref: NAG-1 up-regulation mediated by EGR-1 and p53 is critical for quercetin-induced apoptosis in HCT116 colon carcinoma cells. PMID: 17191121 Ref: Comet fluorescence in situ hybridization analysis for oxidative stress-induced DNA damage in colon cancer relevant genes. PMID: 17192441 Ref: Differential apoptosis by gallotannin in human colon cancer cells with distinct p53 status. PMID: 17192871 Ref: Expression of p53 in colorectal carcinoma: correlation with clinicopathologic features. PMID: 17198452 Ref: Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human. PMID: 17200209 Ref: Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses. PMID: 17201907 Ref: Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells. PMID: 17201910 Ref: Expression analysis of pancreatic cancer cell lines reveals association of enhanced gene transcription and genomic amplifications at the 8q22.1 and 8q24.22 loci. PMID: 17203180 Ref: Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer. PMID: 17203186 Ref: Comparative analysis of predictive biomarkers for therapeutical strategies in colorectal cancer. PMID: 17211733 Ref: Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. PMID: 17218778 Ref: Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines. PMID: 17219422 Ref: Induction of apoptosis and cell-cycle arrest in human colon cancer cells by meclizine. PMID: 17222494 Ref: The additive effect of p53 Arg72Pro and RNASEL Arg462Gln genotypes on age of disease onset in Lynch syndrome patients with pathogenic germline mutations in MSH2 or MLH1. PMID: 17224235 Ref: Targeting serum antibody for cancer diagnosis: a focus on colorectal cancer. PMID: 17227237 Ref: Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study. PMID: 17228023 Ref: The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells. PMID: 17237273 Ref: Cytoplasmic localization of p27 (cyclin-dependent kinase inhibitor 1B/KIP1) in colorectal cancer: inverse correlations with nuclear p27 loss, microsatellite instability, and CpG island methylator phenotype. PMID: 17239930 Ref: 5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint. PMID: 17241873 Ref: Sequence-dependent antitumor effects of differentiation agents in combination with cell cycle-dependent cytotoxic drugs. PMID: 17256134 Ref: Phenotypes of invasion in sporadic colorectal carcinomas related to aberrations of the adenomatous polyposis coli (APC ) gene. PMID: 17257127 Ref: A simple method for the routine detection of somatic quantitative genetic alterations in colorectal cancer. PMID: 17258723 Ref: Mutations in TP53 are a prognostic factor in colorectal hepatic metastases undergoing surgical resection. PMID: 17259658 Ref: BLIMP1 regulates cell growth through repression of p53 transcription. PMID: 17264218 Ref: TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer. PMID: 17270239 Ref: Naphthoindole-based analogues of tryptophan and tryptamine: synthesis and cytotoxic properties. PMID: 17276690 Ref: Early apoptosis and cell death induced by ATX-S10Na (II)-mediated photodynamic therapy are Bax- and p53-dependent in human colon cancer cells. PMID: 17278191 Ref: Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray. PMID: 17278192 Ref: Clinical significance of serum p53 antibodies in patients with ulcerative colitis and its carcinogenesis. PMID: 17285596 Ref: Thymidylate synthase polymorphisms and colon cancer: associations with tumor stage, tumor characteristics and survival. PMID: 17290389 Ref: Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression. PMID: 17292358 Ref: APC mutations and other genetic and epigenetic changes in colon cancer. PMID: 17293392 Ref: Possible role of semaphorin 3F, a candidate tumor suppressor gene at 3p21.3, in p53-regulated tumor angiogenesis suppression. PMID: 17308083 Ref: Absence of cyclooxygenase-2 protein expression is a predictor of tumor regression in rectal cancer treated with preoperative short-term chemoradiotherapy. PMID: 17308999 Ref: Genetic markers predictive of response to induction chemoradiotherapy for locally advanced rectal cancers. PMID: 17310874 Ref: Ribonucleotide reductase subunits M2 and p53R2 are potential biomarkers for metastasis of colon cancer. PMID: 17311703 Ref: Alcohol consumption and distinct molecular pathways to colorectal cancer. PMID: 17313702 Ref: DNA mismatch repair initiates 6-thioguanine--induced autophagy through p53 activation in human tumor cells. PMID: 17317843 Ref: Comparison of oxaliplatin- and curcumin-mediated antiproliferative effects in colorectal cell lines. PMID: 17330230 Ref: Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels. PMID: 17339891 Ref: Inhibition of G1/S transition potentiates oxaliplatin-induced cell death in colon cancer cell lines. PMID: 17343830 Ref: Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. PMID: 17350669 Ref: A case of lymphoepithelioma-like carcinoma of the colon with ulcerative colitis. PMID: 17351809 Ref: Maspin expression was involved in colorectal adenoma-adenocarcinoma sequence and liver metastasis of tumors. PMID: 17352241 Ref: Chromosomal 20q gain in the DNA diploid component of aneuploid colorectal carcinomas. PMID: 17354231 Ref: Molecular genetic changes in epithelial, stromal and mixed neoplasms of the endometrium. PMID: 17365822 Ref: p53 targets identified by protein expression profiling. PMID: 17372198 Ref: BRCA1a has antitumor activity in TN breast, ovarian and prostate cancers. PMID: 17384678 Ref: Expression of EIF3-p48/INT6, TID1 and Patched in cancer, a profiling of multiple tumor types and correlation of expression. PMID: 17385060 Ref: XAF1 mediates apoptosis through an extracellular signal-regulated kinase pathway in colon cancer. PMID: 17385215 Ref: The contribution of p53 in the dynamics of cell cycle response to DNA damage interpreted by a mathematical model. PMID: 17387280 Ref: Autoantibodies to Ca2+ binding protein Calnuc is a potential marker in colon cancer detection. PMID: 17390015 Ref: Clinical significance of p53, K-ras and DCC gene alterations in the stage I-II colorectal cancers. PMID: 17410283 Ref: Low- and high-grade non-invasive gastric neoplasia (formerly dysplasia): cytological differentiation (gastro-entero-pancreatic antigens) in association with p53 pattern expression. PMID: 17419219 Ref: Studies on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of proapoptotic BAX. PMID: 17426704 Ref: Long-term cancer risk of the anorectal cuff following restorative proctocolectomy assessed by p53 expression and cuff dysplasia. PMID: 17432983 Ref: p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells. PMID: 17440101 Ref: Prognostic and predictive value of baseline and posttreatment molecular marker expression in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy. PMID: 17445998 Ref: New mutations in the human p53 gene--a regulator of the cell cycle and carcinogenesis. PMID: 17447881 Ref: NF-kappaB and apoptosis in colorectal tumourigenesis. PMID: 17461988 Ref: Targeting aberrant chromatin structure in colorectal carcinomas. PMID: 17464246 Ref: Histopathological and genetic differences between polypoid and non-polypoid submucosal colorectal carcinoma. PMID: 17465446 Ref: Microarray analysis to reveal genes involved in colon carcinogenesis. PMID: 17472535 Ref: 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high. PMID: 17474983 Ref: 18F-FDG PET scanning correlates with tissue markers of poor prognosis and predicts mortality for patients after liver resection for colorectal metastases. PMID: 17475966 Ref: p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation. PMID: 17486059 Ref: Experimental therapy for colon cancer: anti-cancer effects of TLR9 agonism, combination with other therapeutic modalities, and dependence upon p53. PMID: 17487373 Ref: Onopordum cynarocephalum induces apoptosis and protects against 1,2 dimethylhydrazine-induced colon cancer. PMID: 17487413 Ref: Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2. PMID: 17488476 Ref: The growth-inhibitory effects of tomatoes digested in vitro in colon adenocarcinoma cells occur through down regulation of cyclin D1, Bcl-2 and Bcl-xL. PMID: 17490506 Ref: Apoptosis by cisplatin requires p53 mediated p38alpha MAPK activation through ROS generation. PMID: 17505786 Ref: Identification and quantification of basic and acidic proteins using solution-based two-dimensional protein fractionation and label-free or 18O-labeling mass spectrometry. PMID: 17506541 Ref: Novel small molecule induces p53-dependent apoptosis in human colon cancer cells. PMID: 17509529 Ref: Aspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATM. PMID: 17510082 Ref: Tumour markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines for clinical use. PMID: 17512720 Ref: 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling. PMID: 17513605 Ref: Nanosecond pulsed electric fields induce apoptosis in p53-wildtype and p53-null HCT116 colon carcinoma cells. PMID: 17520193 Ref: Limitations in molecular detection of lymph node micrometastasis from colorectal cancer. PMID: 17525678 Ref: Chromosomal alteration in Chinese sporadic colorectal carcinomas detected by comparative genomic hybridization. PMID: 17525679 Ref: Microsatellite instability in Ewing tumor is not associated with loss of mismatch repair protein expression. PMID: 17530287 Ref: P53 dependent and independent apoptosis induced by lidamycin in human colorectal cancer cells. PMID: 17534142 Ref: Newly established tumourigenic primary human colon cancer cell lines are sensitive to TRAIL-induced apoptosis in vitro and in vivo. PMID: 17551494 Ref: Cumulative expression of HIF-1-alpha, Bax, Bcl-xL and P53 in human colorectal cancer. PMID: 17558861 Ref: The 15-lipoxygenase-1 expression may enhance the sensitivity to non-steroidal anti-inflammatory drug-induced apoptosis in colorectal cancers from patients who are treated with the compounds. PMID: 17559385 Ref: p53 dependent and independent sensitivity to oxaliplatin of colon cancer cells. PMID: 17559811 Ref: Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity. PMID: 17569115 Ref: LKB1 catalytically deficient mutants enhance cyclin D1 expression. PMID: 17575127 Ref: c-FLIP: a key regulator of colorectal cancer cell death. PMID: 17575142 Ref: Photodynamic therapy resistant human colon carcinoma HT29 cells show cross-resistance to UVA but not UVC light. PMID: 17576382 Ref: Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling. PMID: 17578896 Ref: p21 (CDKN1A) is a negative regulator of p53 stability. PMID: 17585201 Ref: Predicting prognosis of rectal cancer patients with total mesorectal excision using molecular markers. PMID: 17589956 Ref: Intraductal papillary cholangiocarcinoma and atypical biliary epithelial lesions confused with intrabiliary extension of metastatic colorectal carcinoma. PMID: 17591040 Ref: Correlations of proliferation markers, p53 expression and histological findings in colorectal carcinoma. PMID: 17592558 Ref: Expression of cyclooxygenase-2 and its relationship to p53 accumulation in colorectal cancers. PMID: 17594159 Ref: Base excision DNA repair defect in Gadd45a-deficient cells. PMID: 17599061 Ref: Association of the TP53 codon 72 polymorphism with colorectal cancer in a Chinese population. PMID: 17599946 Ref: Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin. PMID: 17609769 Ref: Genetic polymorphisms in TP53, nonsteroidal anti-inflammatory drugs and the risk of colorectal cancer: evidence for gene-environment interaction? PMID: 17622940 Ref: Gastrointestinal stromal tumor of the rectum with liver metastasis: report of a case. PMID: 17629050 Ref: [Expression of survivin in colorectal adenoma and adenocarcinoma]. PMID: 17633470 Ref: Regulation of p53 expression in response to 5-fluorouracil in human cancer RKO cells. PMID: 17634554 Ref: Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. PMID: 17638885 Ref: Histone deacetylase inhibitors enhance lexatumumab-induced apoptosis via a p21Cip1-dependent decrease in survivin levels. PMID: 17638911 Ref: Docosahexaenoic acid (DHA), a primary tumor suppressive omega-3 fatty acid, inhibits growth of colorectal cancer independent of p53 mutational status. PMID: 17640164 Ref: The correlation between the immunostains for p53 and Ki67 with bcl-2 expression and classical prognostic factors in colorectal carcinomas. PMID: 17641794 Ref: Nuclear expression of E2F4 induces cell death via multiple pathways in normal human intestinal epithelial crypt cells but not in colon cancer cells. PMID: 17656449 Ref: Involvement of Kruppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma. PMID: 17663506 Ref: p53 codon 72 polymorphism in patients affected with ulcerative colitis. PMID: 17671760 Ref: Value of staining intensity in the interpretation of immunohistochemistry for tumor markers in colorectal cancer. PMID: 17674041 Ref: Mucin expression, p53 overexpression, and peritumoral lymphocytic infiltration of advanced colorectal carcinoma with mucus component: is mucinous carcinoma a distinct histological entity? PMID: 17679024 Ref: Genetic pathways and mutation profiles of human cancers: site- and exposure-specific patterns. PMID: 17693665 Ref: A population-based study of age-related variation in clinicopathological features, molecular. Markers and outcome from colorectal cancer. PMID: 17695456 Ref: High-degree tumor budding and podia-formation in sporadic colorectal carcinomas with K-ras gene mutations. PMID: 17707462 Ref: Clinicopathologic significance in serum presence of anti-p53 antibody in patients with colorectal carcinoma. PMID: 17708268 Ref: Change in expression of apoptosis genes after hyperthermia, chemotherapy and radiotherapy in human colon cancer transplanted into nude mice. PMID: 17708613 Ref: Association of angiogenesis markers with lymph node metastasis in early colorectal cancer. PMID: 17709727 Ref: Molecular portrait of cisplatin induced response in human testis cancer cell lines based on gene expression profiles. PMID: 17711579 Ref: Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca(2+) accumulation in colonocytes. PMID: 17717041 Ref: Importance of MutL homologue MLH1 and MutS homologue MSH2 expression in Turkish patients with sporadic colorectal cancer. PMID: 17724798 Ref: Schedule-dependent cytotoxicity of 5-fluorouracil and irinotecan in p53 mutant human colon cancer. PMID: 17725105 Ref: Focal adhesion kinase and p53 signaling in cancer cells. PMID: 17725966 Ref: [TP53 gene polymorphisms and colorectal cancer risk in Chinese population]. PMID: 17785079 Ref: The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line. PMID: 17786325 Ref: Function of the SIRT1 protein deacetylase in cancer. PMID: 17806102 Ref: Expression of securin promotes colorectal cancer cell death via a p53-independent pathway after radiation. PMID: 17854787 Ref: P21WAF1/CIP1 expression in colorectal carcinomas is related to Kras mutations and prognosis. PMID: 17873613 Ref: Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. PMID: 17875987 Ref: [Effect of lipoteichoic acid of Bifidobacterium on survivin and its regulatory genes]. PMID: 17892124 Ref: The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressor. PMID: 17909040 Ref: Further studies on the arrest of cell proliferation in tumor cells at the invading front of colonic adenocarcinoma. PMID: 17914963 Ref: Modulation of beta-catenin-mediated TCF-signalling in prostate cancer cell lines by wild-type and mutant p53. PMID: 17929268 Ref: Multimodality optical imaging and 18F-FDG uptake in wild-type p53-containing and p53-null human colon tumor xenografts. PMID: 17932466 Ref: Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factor-kappaB/IkappaB kinase signal pathway. PMID: 17938270 Ref: MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines. PMID: 17942928 Ref: p53-dependent change in replication timing of the human genome. PMID: 17949684 Ref: Stimulus-specific transcriptional regulation within the p53 network. PMID: 17957141 Ref: Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells. PMID: 17964072 Ref: Study of molecular mechanisms of pro-apoptotic activity of NCX 4040, a novel nitric oxide-releasing aspirin, in colon cancer cell lines. PMID: 17971198 Ref: [Molecular profile of node-negative colorectal cancer of poor prognosis using immunohistochemical determination of p53, ki67, VEGF, and metalloproteinase-9]. PMID: 17973591 Ref: Can the clinical outcome in stage II colon carcinomas be predicted by determination of molecular marker expression? PMID: 17974527 Ref: Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. PMID: 17974990 Ref: Prognostic value of LISCH7 mRNA in plasma and tumor of colon cancer patients. PMID: 17975147 Ref: Differential response of p53 and p21 on HDAC inhibitor-mediated apoptosis in HCT116 colon cancer cells in vitro and in vivo. PMID: 17982666 Ref: Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatment. PMID: 17982676 Ref: SNP-Array genotyping and spectral karyotyping reveal uniparental disomy as early mutational event in MSS- and MSI-colorectal cancer cell lines. PMID: 18000373 Ref: Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. PMID: 18003927 Ref: Serum p53 antibodies as an early detection marker in colorectal cancer. PMID: 18019675 Ref: Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo. PMID: 18025273 Ref: [Genetic profile and molecular bases of pancreatic carcinogenesis]. PMID: 18028855 Ref: From colonic polyps to colon cancer: pathophysiology, clinical presentation, screening and colonoscopic therapy. PMID: 18043553 Ref: Association between VEGF expression in tumour-associated macrophages and elevated serum VEGF levels in primary colorectal cancer patients. PMID: 18048970 Ref: Rapid DNA extraction protocol from stool, suitable for molecular genetic diagnosis of colon cancer. PMID: 18051782 Ref: Bilirubin inhibits tumor cell growth via activation of ERK. PMID: 18073533 Ref: Investigation of miRNA biology by bioinformatic tools and impact of miRNAs in colorectal cancer--regulatory relationship of c-Myc and p53 with miRNAs. PMID: 18079974 Ref: IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53. PMID: 18084616 Ref: Adduction of human p53 gene by fecal water: an in vitro biomarker of mutagenesis in the human large bowel. PMID: 18086774 Ref: Hsp27 modulates p53 signaling and suppresses cellular senescence. PMID: 18089808 Ref: [Peripheral blood p53 single nucleotide polymorphism analysis for early diagnosis of colorectal carcinoma]. PMID: 18159026 Ref: Antiproliferative activity of cisplatin detected by CFSE in p53-proficient and p53-deficient cells. PMID: 18161532 Ref: PCR-based assessment of the recovery rate of exfoliated colonocytes or cancer cells from fecal samples depends on the storage conditions after defecation. PMID: 18193116 Ref: Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex. PMID: 18220746 Ref: The differentially mutational spectra of the APC, K-ras, and p53 genes in sporadic colorectal cancers from Taiwanese patients. PMID: 18265644 Ref: Tetrandrine: a potent abrogator of G2 checkpoint function in tumor cells and its mechanism. PMID: 18348409 Ref: Predicting 5-year survival of colorectal carcinoma patients using data mining methods. PMID: 18694007 Ref: Clinico-Pathological and Prognostic Significance of p53, Bcl-2 and Her-2/neu Protein Markers in Colorectal Cancer Using Tissue Microarray. PMID: 18839030 Ref: Association between p53 expression and Bcl-2, P-glycoprotein, topoisomerase II alpha, thymidylate synthase and thymidine phosphorylase as potential therapeutic targets in colorectal cancer patients. PMID: 19090149 Ref: Comparison of predicted probabilities of proportional hazards regression and linear discriminant analysis methods using a colorectal cancer molecular biomarker database. PMID: 19455238 Ref: Inhibition of Erythroleukemia Cell Growth by Triplex-forming RNAs. PMID: 21603516 |
Ref: Casiopeina III-ia induces apoptosis in HCT-15 cells in vitro through caspase-dependent mechanisms and has antitumor effect in vivo. PMID: 17390215 Ref: Potential role of apoptosis and apoptotic regulatory proteins in colorectal neoplasia: correlations with clinico-pathological parameters and survival. PMID: 17562177 Ref: Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling and folate uptake in human colonic epithelial cell lines. PMID: 17681772 Ref: Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients. PMID: 17704924 Ref: Survivin, p53, and Ki-67 as predictors of histopathologic response in locally advanced rectal cancer treated with preoperative chemoradiotherapy. PMID: 17805549 Ref: Curcumin as "Curecumin": from kitchen to clinic. PMID: 17900536 Ref: Prognostic significance of cyclooxygenase-2 expression and nuclear p53 accumulation in patients with colorectal cancer. PMID: 17929263 Ref: Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53. PMID: 17942461 Ref: Association of familial colorectal cancer with variants in the E-cadherin (CDH1) and cyclin D1 (CCND1) genes. PMID: 17960397 Ref: Wild-type p53 and p73 negatively regulate expression of proliferation related genes. PMID: 17982488 Ref: p53 regulates FAK expression in human tumor cells. PMID: 17999388 Ref: Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell lines. PMID: 17999988 Ref: PIK3CA cancer mutations display gender and tissue specificity patterns. PMID: 18022911 Ref: Hypersensitivity to chromium-induced DNA damage correlates with constitutive deregulation of upstream p53 kinases in p21-/- HCT116 colon cancer cells. PMID: 18024214 Ref: p53 is important for the anti-proliferative effect of ibuprofen in colon carcinoma cells. PMID: 18036557 Ref: Response of cell cycle/stress-related protein expression and DNA damage upon treatment of CaCo2 cells with anthocyanins. PMID: 18053307 Ref: p53 Nuclear accumulation and Bcl-2 expression in contiguous adenomatous components of colorectal adenocarcinomas predict aggressive tumor behavior. PMID: 18071066 Ref: Abberant crypt foci -- importance in colorectal carcinogenesis and expression of p53 and mdm2: a changing concept. PMID: 18080767 Ref: WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 18084250 Ref: Biological predictive factors in rectal cancer treated with preoperative radiotherapy or radiochemotherapy. PMID: 18087284 Ref: Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis. PMID: 18095365 Ref: The antiapoptotic role of pregnane X receptor in human colon cancer cells. PMID: 18096695 Ref: Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. PMID: 18097482 Ref: Fhit, Mlh1, P53 and phenotypic expression in the early stage of colorectal neoplasms. PMID: 18097574 Ref: Diallyl disulfide induces reversible G2/M phase arrest on a p53-independent mechanism in human colon cancer HCT-116 cells. PMID: 18097607 Ref: Regulation of MDMX expression by mitogenic signaling. PMID: 18172009 Ref: Aberrant crypt foci as precursors of the dysplasia-carcinoma sequence in patients with ulcerative colitis. PMID: 18172251 Ref: Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner. PMID: 18174288 Ref: Colorectal carcinomas from Middle East. Molecular and tissue microarray analysis of genomic instability pathways. PMID: 18176677 Ref: A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization. PMID: 18181020 Ref: Combined analysis of VEGF and EGFR predicts complete tumour response in rectal cancer treated with preoperative radiotherapy. PMID: 18182986 Ref: Reprimo 824 G>C and p53R2 4696 C>G single nucleotide polymorphisms and colorectal cancer: a case-control disease association study. PMID: 18197409 Ref: Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage. PMID: 18208837 Ref: PUMA inactivation protects against oxidative stress through p21/Bcl-XL inhibition of bax death. PMID: 18215742 Ref: Anti-cancer effects of JKA97 are associated with its induction of cell apoptosis via a Bax-dependent and p53-independent pathway. PMID: 18218619 Ref: The different roles of hRAD50 in microsatellite stable and unstable colorectal cancers. PMID: 18219098 Ref: p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage. PMID: 18223691 Ref: Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase. PMID: 18239060 Ref: Sanguinarine causes DNA damage and p53-independent cell death in human colon cancer cell lines. PMID: 18243168 Ref: Combining radiation with oxaliplatin: a review of experimental results. PMID: 18243751 Ref: Genotoxic stress-induced expression of p53 and apoptosis in leukemic clam hemocytes with cytoplasmically sequestered p53. PMID: 18245478 Ref: Progression and tumor heterogeneity analysis in early rectal cancer. PMID: 18245538 Ref: Detection of R337H, a germline TP53 mutation predisposing to multiple cancers, in asymptomatic women participating in a breast cancer screening program in Southern Brazil. PMID: 18248785 Ref: Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells. PMID: 18272544 Ref: Expression of P53, P27 and KI-67 in colorectal cancer patients of various ethnic origins: clinical and tissue microarray based analysis. PMID: 18286523 Ref: Predictive value of Ki67 and p53 in locally advanced rectal cancer: correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy. PMID: 18286688 Ref: IL-4/Stat6 activities correlate with apoptosis and metastasis in colon cancer cells. PMID: 18294957 Ref: A Japanese patient with Li-Fraumeni syndrome who had nine primary malignancies associated with a germline mutation of the p53 tumor-suppressor gene. PMID: 18307025 Ref: MDM2 gene amplification is correlated to tumor progression but not to the presence of SNP309 or TP53 mutational status in primary colorectal cancers. PMID: 18314481 Ref: The AP-2alpha transcription factor is required for the ganglioside GM3-stimulated transcriptional regulation of a PTEN gene. PMID: 18316341 Ref: hTERT expression in colorectal adenocarcinoma: correlations with p21, p53 expressions and clinicopathological features. PMID: 18322660 Ref: Colorectal carcinoma prognosis can be predicted by alterations in gene p53 exons 5 and 8. PMID: 18322661 Ref: CUGBP2 downregulation by prostaglandin E2 protects colon cancer cells from radiation-induced mitotic catastrophe. PMID: 18325984 Ref: Prognostic and predictive factors in colorectal cancer. PMID: 18326017 Ref: Anti-p53 autoantibody in colorectal cancer: prognostic significance in long-term follow-up. PMID: 18330580 Ref: P53 mutations in colorectal cancer from northern Iran: Relationships with site of tumor origin, microsatellite instability and K-ras mutations. PMID: 18330889 Ref: A chemotherapy-associated senescence bystander effect in breast cancer cells. PMID: 18340112 Ref: P53-mediated upregulation of DcR1 impairs oxaliplatin/TRAIL-induced synergistic anti-tumour potential in colon cancer cells. PMID: 18345033 Ref: Anti-colon cancer effects of Salograviolide A isolated from Centaurea ainetensis. PMID: 18357373 Ref: The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines. PMID: 18357397 Ref: Growth associated proteins in tumor cells and stroma related to disease progression of colon cancer accounting for tumor tissue PGE2 content. PMID: 18360718 Ref: An indicator of cancer: downregulation of monoamine oxidase-A in multiple organs and species. PMID: 18366702 Ref: The BH3-only protein PUMA is involved in green tea polyphenol-induced apoptosis in colorectal cancer cell lines. PMID: 18367875 Ref: Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and beta-catenin expression: a different pathway from the polypoid adenoma-carcinoma sequence. PMID: 18370954 Ref: Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells. PMID: 18377871 Ref: Critical role of Bid and Bax in indirubin-3'-monoxime-induced apoptosis in human cancer cells. PMID: 18377873 Ref: The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner. PMID: 18381438 Ref: Genetic variants in germline TP53 and MDM2 SNP309 are not associated with early onset colorectal cancer. PMID: 18381604 Ref: New method for colorectal cancer diagnosis based on SSCP analysis of DNA from exfoliated colonocytes in naturally evacuated feces. PMID: 18383838 Ref: [Association of TP53 gene polymorphisms with genetic susceptibility to liver metastases of colorectal cancer]. PMID: 18393238 Ref: Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras. PMID: 18398843 Ref: De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. PMID: 18400537 Ref: Human Delta1-pyrroline-5-carboxylate synthase: function and regulation. PMID: 18401542 Ref: DUSP1 is controlled by p53 during the cellular response to oxidative stress. PMID: 18403641 Ref: The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells. PMID: 18413749 Ref: Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status. PMID: 18413751 Ref: A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model. PMID: 18418047 Ref: Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis. PMID: 18419600 Ref: Individual tumorigenesis pathways of sporadic colorectal adenocarcinomas are associated with the biological behavior of tumors. PMID: 18422752 Ref: P53 and bcl-2 in colorectal cancer arising in patients under 40 years of age: distribution and prognostic relevance. PMID: 18424032 Ref: Methylation alterations are not a major cause of PTTG1 misregulation. PMID: 18426563 Ref: Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells. PMID: 18430410 Ref: Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma. PMID: 18451217 Ref: Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir. PMID: 18452174 Ref: Oncogene and tumor suppressor gene expression changes in the peripheral blood leukocytes of patients with colorectal cancer. PMID: 18468340 Ref: Reversible dysfunction of wild-type p53 following homeodomain-interacting protein kinase-2 knockdown. PMID: 18483253 Ref: Trans- and cis-stilbene polyphenols induced rapid perinuclear mitochondrial clustering and p53-independent apoptosis in cancer cells but not normal cells. PMID: 18486125 Ref: Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics. PMID: 18486467 Ref: Mesalazine negatively regulates CDC25A protein expression and promotes accumulation of colon cancer cells in S phase. PMID: 18495657 Ref: Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53. PMID: 18497562 Ref: Mechanism of resistance to chemoradiation in p53 mutant human colon cancer. PMID: 18497992 Ref: Familial adenomatous polyposis: analysis of genetic instability of microsatellites Loci and genetic alternations of tumor suppressor genes. PMID: 18498268 Ref: Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells. PMID: 18504430 Ref: P53Arg72 homozygosity and its increased incidence in left-sided sporadic colorectal adenocarcinomas, in a Greek-Caucasian population. PMID: 18507052 Ref: Crude extracts of Solanum lyratum induced cytotoxicity and apoptosis in a human colon adenocarcinoma cell line (colo 205). PMID: 18507053 Ref: Oxaliplatin activity in selected and unselected human ovarian and colorectal cancer cell lines. PMID: 18508032 Ref: Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial. PMID: 18509181 Ref: PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations. PMID: 18516290 Ref: Ki-67, p53 and bcl-2 analysis in colonic versus rectal adenocarcinoma. PMID: 18516322 Ref: Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. PMID: 18519671 Ref: The iroquois homeobox gene 5 is regulated by 1,25-dihydroxyvitamin D3 in human prostate cancer and regulates apoptosis and the cell cycle in LNCaP prostate cancer cells. PMID: 18519790 Ref: E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines. PMID: 18521084 Ref: P53 expression in synchronous colorectal cancer. PMID: 18521459 Ref: Elevated p21 expression is associated with poor prognosis of rectal stromal tumors after resection. PMID: 18521824 Ref: Deregulated expression of miR-106a predicts survival in human colon cancer patients. PMID: 18521848 Ref: p73 Isoforms affect VEGF, VEGF165b and PEDF expression in human colorectal tumors: VEGF165b downregulation as a marker of poor prognosis. PMID: 18546269 Ref: CANu1, a novel nucleolar protein, accumulated on centromere in response to DNA damage. PMID: 18547334 Ref: Differential cancer predisposition in Lynch syndrome: insights from molecular analysis of brain and urinary tract tumors. PMID: 18550572 Ref: RHAMM, p21 combined phenotype identifies microsatellite instability-high colorectal cancers with a highly adverse prognosis. PMID: 18559599 Ref: Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: the role of p53 and p21. PMID: 18561895 Ref: Eps8 decreases chemosensitivity and affects survival of cervical cancer patients. PMID: 18566210 Ref: Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer. PMID: 18566224 Ref: Proinflammatory cytokines cause FAT10 upregulation in cancers of liver and colon. PMID: 18574467 Ref: Analysis of the K-ras/B-raf/Erk signal cascade, p53 and CMAP as markers for tumor progression in colorectal cancer patients. PMID: 18575712 Ref: Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage. PMID: 18594007 Ref: Overexpression of WNT2 and TSG101 genes in colorectal carcinoma. PMID: 18600204 Ref: Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells. PMID: 18600534 Ref: MDM2 mRNA expression in the p53 pathway may predict the potential of invasion and liver metastasis in colorectal cancer. PMID: 18607552 Ref: Folate and vitamin B6 intake and risk of colon cancer in relation to p53 expression. PMID: 18619459 Ref: The ubiquitin-proteasome system in colorectal cancer. PMID: 18619533 Ref: Genetic alterations in colorectal cancers with demethylation of insulin-like growth factor II. PMID: 18619647 Ref: Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide. PMID: 18619950 Ref: Growth inhibition and apoptosis induction by tanshinone IIA in human colon adenocarcinoma cells. PMID: 18622903 Ref: Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter. PMID: 18628250 Ref: GSTM, GSTT and p53 polymorphisms as modifiers of clinical outcome in colorectal cancer. PMID: 18630481 Ref: Enhancement of sodium butyrate-induced cell death by hyperthermia in HCT 116 human colorectal cancer cells. PMID: 18630528 Ref: Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells. PMID: 18632613 Ref: Prognostic analysis of rectal stromal tumors by reference of National Institutes of Health risk categories and immunohistochemical studies. PMID: 18633679 Ref: Moderate variations in CDC25B protein levels modulate the response to DNA damaging agents. PMID: 18635965 Ref: Enhancement of sodium butyrate-induced cell death and apoptosis by X-irradiation in the human colorectal cancer cell line HCT 116. PMID: 18636204 Ref: 5,5'-Dibromo-bis(3'-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cells. PMID: 18645021 Ref: Differential antiproliferative mechanisms of novel derivative of benzimidazo[1,2-alpha]quinoline in colon cancer cells depending on their p53 status. PMID: 18645022 Ref: Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress. PMID: 18663430 Ref: Preoperative radiochemotherapy is successful also in patients with locally advanced rectal cancer who have intrinsically high apoptotic tumours. PMID: 18664561 Ref: Single cell cytometry of protein function in RNAi treated cells and in native populations. PMID: 18673568 Ref: K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy. PMID: 18676755 Ref: Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation. PMID: 18677110 Ref: [Ki-67 and p53 expressions versus differentiation degrees of colon adenocarcinoma]. PMID: 18677924 Ref: Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers. PMID: 18691581 Ref: Tumor suppressor gene insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) induces senescence-like growth arrest in colorectal cancer cells. PMID: 18701096 Ref: Suppression of inhibitor of differentiation 2, a target of mutant p53, is required for gain-of-function mutations. PMID: 18701504 Ref: Full-length hdmX transcripts decrease following genotoxic stress. PMID: 18711402 Ref: Role of DNA repair systems in malignant tumor development in the elderly. PMID: 18713157 Ref: S-adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis. PMID: 18713839 Ref: Mitochondrially targeted wild-type p53 induces apoptosis in a solid human tumor xenograft model. PMID: 18719383 Ref: A new formula for predicting liver metastasis in patients with colorectal cancer: immunohistochemical analysis of a large series of 439 surgically resected cases. PMID: 18728370 Ref: Poorer outcome in stromal HIF-2 alpha- and CA9-positive colorectal adenocarcinomas is associated with wild-type TP53 but not with BNIP3 promoter hypermethylation or apoptosis. PMID: 18728663 Ref: miR-34a repression of SIRT1 regulates apoptosis. PMID: 18755897 Ref: Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID: 18756595 Ref: Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways. PMID: 18758483 Ref: The expression of cytoskeleton regulatory protein Mena in colorectal lesions. PMID: 18758639 Ref: Celecoxib induces p53-PUMA pathway for apoptosis in human colorectal cancer cells. PMID: 18760266 Ref: [A pilot experience with a tumor bank]. PMID: 18769829 Ref: Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation- status. PMID: 18781614 Ref: Morphologic and molecular events at the invading edge of colorectal carcinomas. PMID: 18784803 Ref: 15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity. PMID: 18785202 Ref: Characterization of humoral immune responses against p16, p53, HPV16 E6 and HPV16 E7 in patients with HPV-associated cancers. PMID: 18785210 Ref: Anti colon cancer components from Lebanese sage (Salvia libanotica) essential oil: Mechanistic basis. PMID: 18787402 Ref: Mithramycin SK modulates polyploidy and cell death in colon carcinoma cells. PMID: 18790779 Ref: Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers. PMID: 18794809 Ref: WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis. PMID: 18806757 Ref: Differential proteome expression associated with urokinase plasminogen activator receptor (uPAR) suppression in malignant epithelial cancer. PMID: 18808175 Ref: Mutant p53 protein localized in the cytoplasm inhibits autophagy. PMID: 18818522 Ref: Prognostic and predictive factors in colorectal cancer. PMID: 18832400 Ref: APC shuttling to the membrane, nucleus and beyond. PMID: 18848448 Ref: Hexane/ethanol extract of Glycyrrhiza uralensis licorice suppresses doxorubicin-induced apoptosis in H9c2 rat cardiac myoblasts. PMID: 18849542 Ref: 15-deoxy-Delta12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription. PMID: 18852146 Ref: Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73alpha tumor suppressor. PMID: 18922894 Ref: [Epigenetic alterations in colorectal carcinomas and precancerous lesions]. PMID: 18937191 Ref: Epigenetic events in normal colonic mucosa surrounding colorectal cancer lesions. PMID: 18938072 Ref: Growth inhibition and apoptosis induction by tanshinone I in human colon cancer Colo 205 cells. PMID: 18949381 Ref: [Genetic polymorphism in MDM2 is associated with susceptibility to colorectal cancer in a Chinese population]. PMID: 18953830 Ref: Cohort study of fatty acid synthase expression and patient survival in colon cancer. PMID: 18955444 Ref: Cyclin D1 is frequently overexpressed in microsatellite unstable colorectal cancer, independent of CpG island methylator phenotype. PMID: 18983468 Ref: Two-marker protein profile predicts poor prognosis in patients with early rectal cancer. 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PMID: 21530747 Ref: Detection of tumor DNA at the margins of colorectal cancer liver metastasis. PMID: 21531819 Ref: Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations. PMID: 21537397 Ref: Effects of alpha-mangostin on apoptosis induction of human colon cancer. PMID: 21547127 Ref: Peritoneal carcinomatosis of colon cancer origin: highest incidence in women and in patients with right-sided tumors. PMID: 21547915 Ref: Evaluation of the effects of the flavonoid apigenin on apoptotic pathway gene expression on the colon cancer cell line (HT29). PMID: 21548803 Ref: Induction of apoptosis in colon cancer cells by a novel topoisomerase I inhibitor TopIn. PMID: 21549095 Ref: Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53. PMID: 21557998 Ref: Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis. PMID: 21566225 Ref: Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts. PMID: 21567080 Ref: Folate receptor-alpha expression in resectable hepatic colorectal cancer metastases: patterns and significance. PMID: 21572402 Ref: Overexpression of miR-22 reverses paclitaxel-induced chemoresistance through activation of PTEN signaling in p53-mutated colon cancer cells. PMID: 21594648 Ref: TP53 codon 72 polymorphism and P53 protein expression in colorectal cancer specimens in Isfahan. PMID: 21598212 Ref: Detection of Brk expression in non-small cell lung cancer: clinicopathological relevance. PMID: 21603980 Ref: p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation. PMID: 21606339 Ref: 5-Methoxyflavanone induces cell cycle arrest at the G2/M phase, apoptosis and autophagy in HCT116 human colon cancer cells. PMID: 21616090 Ref: Aspirin reduces the apoptotic effect of etoposide via Akt activation and up-regulation of p21(cip). PMID: 21617849 Ref: Relative role of methylator and tumor suppressor pathways in ulcerative colitis-associated colon cancer. PMID: 21618350 Ref: Inhibition of VEGF induces cellular senescence in colorectal cancer cells. PMID: 21618508 Ref: A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5-FU treatment. PMID: 21619678 Ref: The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action. PMID: 21620827 Ref: Resveratrol potentiates grape seed extract induced human colon cancer cell apoptosis. PMID: 21622155 Ref: Calbindin 2 (CALB2) regulates 5-fluorouracil sensitivity in colorectal cancer by modulating the intrinsic apoptotic pathway. PMID: 21629658 Ref: Dual role of insulin-like growth factor-1 in acetyl-CoA carboxylase-alpha activity in human colon cancer cells HCT-8: downregulating its expression and phosphorylation. PMID: 21638027 Ref: Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity. PMID: 21639915 Ref: Pathogenesis and biomarkers of carcinogenesis in ulcerative colitis. PMID: 21647200 Ref: Dicaffeoylquinic acids in Yerba mate (Ilex paraguariensis St. Hilaire) inhibit NF-kappaB nucleus translocation in macrophages and induce apoptosis by activating caspases-8 and -3 in human colon cancer cells. PMID: 21656672 Ref: Colonic carcinogenesis in IBD: molecular events. PMID: 21657151 Ref: Distinctive patterns of p53 protein expression and microsatellite instability in human colorectal cancer. PMID: 21665242 Ref: Immunohistochemical investigation of tumorigenic pathways in sinonasal intestinal-type adenocarcinoma. A tissue microarray analysis of 62 cases. PMID: 21668475 Ref: Relationship between TP73 polymorphism (G4C14-A4T14) and cancer risk: a meta-analysis based on literatures. PMID: 21672615 Ref: DNA damage signaling in response to 5-fluorouracil in three colorectal cancer cell lines with different mismatch repair and TP53 status. PMID: 21674128 Ref: Site impact on colorectal cancer biological behavior in terms of clinicopathological and molecular features. PMID: 21674855 Ref: Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. PMID: 21678067 Ref: Protein kinase CK2alpha is overexpressed in colorectal cancer and modulates cell proliferation and invasion via regulating EMT-related genes. PMID: 21702981 Ref: The relative contribution of pro-apoptotic p53-target genes in the triggering of apoptosis following DNA damage in vitro and in vivo. PMID: 21709442 Ref: Overexpression of neurone glial-related cell adhesion molecule is an independent predictor of poor prognosis in advanced colorectal cancer. PMID: 21718388 Ref: The depletion of DNA methyltransferase-1 and the epigenetic effects of 5-aza-2'deoxycytidine (decitabine) are differentially regulated by cell cycle progression. PMID: 21725200 Ref: Quinacrine synergizes with 5-fluorouracil and other therapies in colorectal cancer. PMID: 21725213 Ref: Colon cancer: a civilization disorder. PMID: 21734388 Ref: VEGFA gene locus (6p12) amplification identifies a small but highly aggressive subgroup of colorectal cancer [corrected] patients. PMID: 21743435 Ref: Role of cyclophilin B in tumorigenesis and cisplatin resistance in hepatocellular carcinoma in humans. PMID: 21748762 Ref: Prognostic significance of miR-215 in colon cancer. PMID: 21752725 Ref: High expression of testes-specific protease 50 is associated with poor prognosis in colorectal carcinoma. PMID: 21765952 Ref: Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells. PMID: 21774804 Ref: p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200. PMID: 21775823 Ref: Study of the Anti-Proliferative Activity of 5-Substituted 4,7-Dimethoxy-1,3-Benzodioxole Derivatives of SY-1 from Antrodia camphorata on Human COLO 205 Colon Cancer Cells. PMID: 21785624 Ref: Expression of p53 and DR5 in normal and malignant tissues of colorectal cancer: correlation with advanced stages. PMID: 21805040 Ref: Molecular basis for the actions of Hsp90 inhibitors and cancer therapy. PMID: 21811259 Ref: Pretreatment CD133 and cyclooxygenase-2 expression as the predictive markers of the pathological effect of chemoradiotherapy in rectal cancer patients. PMID: 21825889 Ref: Honokiol radiosensitizes colorectal cancer cells: enhanced activity in cells with mismatch repair defects. PMID: 21836060 Ref: Familial colorectal cancer type X syndrome: two distinct molecular entities? PMID: 21837511 Ref: PTTG1 attenuates drug-induced cellular senescence. PMID: 21858218 Ref: Identification of a biomarker profile associated with resistance to neoadjuvant chemoradiation therapy in rectal cancer. PMID: 21865946 Ref: [Preliminary study on relationship between multi-drug resistance-associated protein 4 and radiosensitivity of rectal cancer]. PMID: 21866459 Ref: Prognostic significance of thymidylate synthase expression in the adjuvant chemotherapy after resection for pulmonary metastases from colorectal cancer. PMID: 21868518 Ref: Cell cycle arrest and apoptosis induced by methyl 3,5-dicaffeoyl quinate in human colon cancer cells: Involvement of the PI3K/Akt and MAP kinase pathways. PMID: 21872580 Ref: Goblet cell carcinoid of the rectum with lymph node metastasis: report of a case. PMID: 21874432 Ref: Reduced level of ribonucleotide reductase R2 subunits increases dependence on homologous recombination repair of cisplatin-induced DNA damage. PMID: 21875941 Ref: Molecular genetic analysis of 103 sporadic colorectal tumours in Czech patients. PMID: 21901162 Ref: Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome. PMID: 21909432 Ref: Platinum-(IV)-derivative satraplatin induced G2/M cell cycle perturbation via p53-p21(waf1/cip1)-independent pathway in human colorectal cancer cells. PMID: 21927014 Ref: Aloe vera non-decolorized whole leaf extract-induced large intestinal tumors in F344 rats share similar molecular pathways with human sporadic colorectal tumors. PMID: 21937742 Ref: The prognostic role of apoptosis mediators in rectal adenocarcinoma. PMID: 21940317 Ref: NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor. PMID: 21952639 Ref: Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk of gastric and colorectal cancer in Turkish population. PMID: 21971103 Ref: Tumor-specific usage of alternative transcription start sites in colorectal cancer identified by genome-wide exon array analysis. PMID: 21999571 Ref: Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53. PMID: 22022355 Ref: Tissue microarrays in Chinese human rectal cancer: study of expressions of the tumor-associated genes. PMID: 22024062 Ref: Significance of mRNA and protein expression of MAC30 in progression of colorectal cancer. PMID: 22024687 Ref: Expression of activation-induced cytidine deaminase in ulcerative colitis-associated carcinogenesis. PMID: 22034886 Ref: p53 and microRNA-34 are suppressors of canonical Wnt signaling. PMID: 22045851 Ref: Synchronized release of Doxil and Nutlin-3 by remote degradation of polysaccharide matrices and its possible use in the local treatment of colorectal cancer. PMID: 22082104 Ref: Expression of p16INK4a, alone or combined with p53, is predictive of better prognosis in colorectal adenocarcinoma in Tunisian patients. PMID: 22095233 Ref: Hedgehog signaling and the Gli code in stem cells, cancer, and metastases. PMID: 22114144 Ref: Aurora A mediates cross-talk between N- and C-terminal post-translational modifications of p53. PMID: 22157150 Ref: Expression of circadian clock gene human Period2 (hPer2) in human colorectal carcinoma. PMID: 22166120 Ref: Cancer chemopreventive ability of conjugated linolenic acids. PMID: 22174613 Ref: Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. PMID: 22195963 Ref: Genetic variability in EGFR, Src and HER2 and risk of colorectal adenoma and cancer. PMID: 22199994 Ref: P53 codon 72 polymorphism and colorectal cancer: a meta-analysis of epidemiological studies. PMID: 22234063 Ref: Association of Arg72Pro of P53 polymorphism with colorectal cancer susceptibility risk in Malaysian population. PMID: 22393962 Ref: Detection of serum anti-P53 antibodies from patients with colorectal cancer in China using a combination of P53- and phage-ELISA: correlation to clinical parameters. PMID: 22393964 Ref: Over-expression of Metastasis-associated in Colon Cancer-1 (MACC1) Associates with Better Prognosis of Gastric Cancer Patients. PMID: 23483020 Ref: The Prognostic Impact of p53 Expression on Sporadic Colorectal Cancer Is Dependent on p21 Status. PMID: 24212661 Ref: Predictive factors of the response of rectal cancer to neoadjuvant radiochemotherapy. PMID: 24212803 Ref: Gastric cancer following total proctocolectomy for colon cancer associated with ulcerative colitis. PMID: 26189522 Ref: Role of CD34, vascular endothelial growth factor, and p53 in neoangiogenesis as correlated with stage of disease in colorectal carcinoma. PMID: 27365839 |
Ref: A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen. PMID: 21494837 Ref: Role of immunohistochemical markers in predicting progression of dysplasia to advanced neoplasia in patients with ulcerative colitis. PMID: 21509910 Ref: PNAS-4 expression and its relationship to p53 in colorectal cancer. PMID: 21556770 Ref: p53 mutation is common in microsatellite stable, BRAF mutant colorectal cancers. PMID: 21557216 Ref: Pharmacological inhibition of Mdm2 triggers growth arrest and promotes DNA breakage in mouse colon tumors and human colon cancer cells. PMID: 21557332 Ref: Combined analysis of the association between p73 G4C14-to-A4T14 polymorphisms and cancer risk. PMID: 21617940 Ref: Genome-scale analysis of aberrant DNA methylation in colorectal cancer. PMID: 21659424 Ref: XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification. PMID: 21678496 Ref: The use of molecular markers as a method to predict the response to neoadjuvant therapy for advanced stage rectal adenocarcinoma. PMID: 21689364 Ref: Identification of spliced variants of the proto-oncogene HDM2 in colorectal cancer. PMID: 21761395 Ref: MDM2 SNP309 polymorphism and colorectal cancer risk: a meta-analysis. PMID: 21770737 Ref: Cardamonin sensitizes tumour cells to TRAIL through ROS- and CHOP-mediated up-regulation of death receptors and down-regulation of survival proteins. PMID: 21797841 Ref: Effects of DeltaNp73beta on cisplatin treatment in colon cancer cells. PMID: 21837762 Ref: P38MAPK is a major determinant of the balance between apoptosis and autophagy triggered by 5-fluorouracil: implication in resistance. PMID: 21841826 Ref: Apoptotic proteins as prognostic markers and indicators of radiochemosensitivity in stage II/III rectal cancers. PMID: 21848899 Ref: Platinum anticancer agents and antidepressants: desipramine enhances platinum-based cytotoxicity in human colon cancer cells. PMID: 21918844 Ref: Key role of ATF3 in p53-dependent DR5 induction upon DNA damage of human colon cancer cells. PMID: 21927023 Ref: USP22 acts as an oncogene by the activation of BMI-1-mediated INK4a/ARF pathway and Akt pathway. PMID: 21928107 Ref: The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function. PMID: 21964066 Ref: Role and interaction of p53, BAX and the stress-activated protein kinases p38 and JNK in benzo(a)pyrene-diolepoxide induced apoptosis in human colon carcinoma cells. PMID: 21983885 Ref: Inhibition of beta-catenin signaling by nongenomic action of orphan nuclear receptor Nur77. PMID: 21986938 Ref: B1, a novel topoisomerase II inhibitor, induces apoptosis and cell cycle G1 arrest in lung adenocarcinoma A549 cells. PMID: 22008852 Ref: Association between the p73 exon 2 G4C14-to-A4T14 polymorphism and cancer risk: a meta-analysis. PMID: 22011187 Ref: Stool-fermented Plantago ovata husk induces apoptosis in colorectal cancer cells independently of molecular phenotype. PMID: 22018732 Ref: Distinct genetic and epigenetic signatures of colorectal cancers according to ethnic origin. PMID: 22028395 Ref: Tumor TP53 expression status, body mass index and prognosis in colorectal cancer. PMID: 22038927 Ref: Evaluation of copper-64-labeled somatostatin agonists and antagonist in SSTr2-transfected cell lines that are positive and negative for p53: implications for cancer therapy. PMID: 22056254 Ref: Reevaluation of serum p53 antibody as a tumor marker in colorectal cancer patients. PMID: 22075664 Ref: Pleomorphic adenoma gene-like 2 regulates expression of the p53 family member, p73, and induces cell cycle block and apoptosis in human promonocytic U937 cells. PMID: 22076304 Ref: Role of p21 as a determinant of 1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane response in human HCT-116 colon carcinoma cells. PMID: 22076474 Ref: Expression of SPRR3 is associated with tumor cell proliferation in less advanced stages of breast cancer. PMID: 22076481 Ref: Two initiation sites of early detection of colon cancer, revealed by localization of pERK1/2 in the nuclei or in aggregates at the perinuclear region of tumor cells. PMID: 22108866 Ref: Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death. PMID: 22120717 Ref: The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells. PMID: 22134899 Ref: Hsp90 inhibitors sensitise human colon cancer cells to topoisomerase I poisons by depletion of key anti-apoptotic and cell cycle checkpoint proteins. PMID: 22138446 Ref: Disparate clinicopathological correlations of p53 and Bcl-2 in colorectal cancer. PMID: 22143931 Ref: Genetic variability in IL23R and risk of colorectal adenoma and colorectal cancer. PMID: 22154103 Ref: The phosphoinositide 3-kinase inhibitor LY294002, decreases aminoacyl-tRNA synthetases, chaperones and glycolytic enzymes in human HT-29 colorectal cancer cells. PMID: 22172953 Ref: The indolic diet-derivative, 3,3'-diindolylmethane, induced apoptosis in human colon cancer cells through upregulation of NDRG1. PMID: 22187533 Ref: TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens. PMID: 22188812 Ref: Differences in gene expression profiles and carcinogenesis pathways between colon and rectal cancer. PMID: 22188913 Ref: The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. PMID: 22190494 Ref: COLD-PCR enrichment of rare cancer mutations prior to targeted amplicon resequencing. PMID: 22194627 Ref: MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1. PMID: 22198213 Ref: The influence of 5-aminosalicylic acid on the progression of colorectal adenomas via the beta-catenin signaling pathway. PMID: 22198215 Ref: The complex intratumoral heterogeneity of colon cancer highlighted by laser microdissection. PMID: 22198706 Ref: Selenite-induced apoptosis and autophagy in colon cancer cells. PMID: 22200533 Ref: Abrogation of Gli3 expression suppresses the growth of colon cancer cells via activation of p53. PMID: 22227409 Ref: Differential microRNA expression tracks neoplastic progression in inflammatory bowel disease-associated colorectal cancer. PMID: 22241525 Ref: Assessment of the novel tubulin-binding agent EHT 6706 in combination with ionizing radiation or chemotherapy. PMID: 22246215 Ref: p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors. PMID: 22262171 Ref: Impact of MDM2 polymorphism: increased risk of developing colorectal cancer and a poor prognosis in the Tunisian population. PMID: 22266832 Ref: Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer. PMID: 22270257 Ref: MiR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL. PMID: 22287560 Ref: Hypoxia and TP53 deficiency for induced pluripotent stem cell-like properties in gastrointestinal cancer. PMID: 22293932 Ref: Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells. PMID: 22294162 Ref: Mutations and polymorphisms in TP53 gene--an overview on the role in colorectal cancer. PMID: 22294769 Ref: Aging alters folate homeostasis and DNA damage response in colon. PMID: 22306610 Ref: DNA demethylation in normal colon tissue predicts predisposition to multiple cancers. PMID: 22310288 Ref: CIP2A overexpression is associated with c-Myc expression in colorectal cancer. PMID: 22310977 Ref: Cell cycle proteins predict recurrence in stage II and III colon cancer. PMID: 22311118 Ref: Antiproliferative effects of a new alpha-lipoic acid derivative, DHL-HisZnNa, in HT29 human colon cancer cells in vitro. PMID: 22313417 Ref: DNA alterations of microsatellite DNA, p53, APC and K-ras in Chinese colorectal cancer patients. PMID: 22324744 Ref: Down-regulation of MutS homolog 3 by hypoxia in human colorectal cancer. PMID: 22343000 Ref: DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells. PMID: 22349266 Ref: Over-expression of GAPDH in human colorectal carcinoma as a preferred target of 3-bromopyruvate propyl ester. PMID: 22350014 Ref: REGgamma is associated with multiple oncogenic pathways in human cancers. PMID: 22361172 Ref: Thermotherapy enhances oxaliplatin-induced cytotoxicity in human colon carcinoma cells. PMID: 22363135 Ref: Glutathione peroxidase tagSNPs: associations with rectal cancer but not with colon cancer. PMID: 22371331 Ref: Different mutation profiles associated to P53 accumulation in colorectal cancer. PMID: 22373952 Ref: The chemopreventive agent ursodeoxycholic acid inhibits proliferation of colon carcinoma cells by suppressing c-Myc expression. PMID: 22395148 Ref: Molecular alterations in colitis-associated colorectal neoplasia: study from a low prevalence area using magnifying chromo colonoscopy. PMID: 22398042 Ref: Screening for epigenetically masked genes in colorectal cancer Using 5-Aza-2'-deoxycytidine, microarray and gene expression profile. PMID: 22399497 Ref: Proteomic identification of chaperonin-containing tail-less complex polypeptide-1 gamma subunit as a p53-responsive protein in colon cancer cells. PMID: 22399500 Ref: The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively. PMID: 22399804 Ref: p53-Independent expression of wild-type p53-induced phosphatase 1 (Wip1) in methylmethane sulfonate-treated cancer cell lines and human tumors. PMID: 22405851 Ref: Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC delta-independent mechanism. PMID: 22410117 Ref: Correlations between clinicopathological parameters and molecular signatures of primary tumors for patients with stage T3n0 colorectal adenocarcinomas: a single center retrospective study on 100 cases. PMID: 22414548 Ref: Analysis of exosome release and its prognostic value in human colorectal cancer. PMID: 22420032 Ref: Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer. PMID: 22426808 Ref: In vivo antitumor effects of 4,7-dimethoxy-5-methyl-1,3-benzodioxole isolated from the fruiting body of Antrodia camphorata through activation of the p53-mediated p27/Kip1 signaling pathway. PMID: 22429157 Ref: Differential expression of senescence and cell death factors in non-small cell lung and colorectal tumors showing telomere attrition. PMID: 22433385 Ref: Down-regulation of Fer induces ROS levels accompanied by ATM and p53 activation in colon carcinoma cells. PMID: 22434045 Ref: Selective killing of p53-deficient cancer cells by SP600125. PMID: 22438244 Ref: Synergistic anticancer effect of rAd/P53 combined with 5-fluorouracil or iodized oil in the early therapeutic response of human colon cancer in vivo. PMID: 22441128 Ref: Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer. PMID: 22444159 Ref: Cellular apoptosis susceptibility (chromosome segregation 1-like, CSE1L) gene is a key regulator of apoptosis, migration and invasion in colorectal cancer. PMID: 22450763 Ref: [Long non-coding RNA influences radiosensitivity of colorectal carcinoma cell lines by regulating cyclin D1 expression]. PMID: 22454180 Ref: Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer. PMID: 22473991 Ref: Activations of Both Extrinsic and Intrinsic Pathways in HCT 116 Human Colorectal Cancer Cells Contribute to Apoptosis through p53-Mediated ATM/Fas Signaling by Emilia sonchifolia Extract, a Folklore Medicinal Plant. PMID: 22474491 Ref: Hypoxia-inducible factor 1 regulated ARC expression mediated hypoxia induced inactivation of the intrinsic death pathway in p53 deficient human colon cancer cells. PMID: 22475487 Ref: Immunohistochemical evaluation of p53 and Ki-67 proteins in colorectal adenomas. PMID: 22481684 Ref: Comparison of the chemosensitivity of the primary lesion and a pancreatic metastasis of colon cancer: a case report. PMID: 22493386 Ref: hERG1 Channels and Glut-1 as Independent Prognostic Indicators of Worse Outcome in Stage I and II Colorectal Cancer: A Pilot Study. PMID: 22496927 Ref: Use of multiple biomarkers for the localization and characterization of colon cancer stem cells by indirect immunocytochemistry. PMID: 22504585 Ref: Postmenopausal hormone therapy is associated with a reduced risk of colorectal cancer lacking CDKN1A expression. PMID: 22511578 Ref: Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D. PMID: 22514644 Ref: Combined metallothioneins and p53 proteins expression as a prognostic marker in patients with Dukes stage B and C colorectal cancer. PMID: 22516242 Ref: The combination of olaparib and camptothecin for effective radiosensitization. PMID: 22524618 Ref: Reduced telomere length in colorectal carcinomas. PMID: 22524803 Ref: Cell death induced by the Alternaria mycotoxin Alternariol. PMID: 22542754 Ref: The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways. PMID: 22552631 Ref: The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer. PMID: 22558377 Ref: Oxidatively damaged DNA and its repair in colon carcinogenesis. PMID: 22561673 Ref: Acriflavine enhances radiosensitivity of colon cancer cells through endoplasmic reticulum stress-mediated apoptosis. PMID: 22564437 Ref: Genetic alterations in colorectal cancer. PMID: 22574233 Ref: Chk2 phosphorylation of survivin-DeltaEx3 contributes to a DNA damage-sensing checkpoint in cancer. PMID: 22586065 Ref: Preferential killing of p53-deficient cancer cells by reversine. PMID: 22592527 Ref: Utility of cell-free tumour DNA for post-surgical follow-up of colorectal cancer patients. PMID: 22593440 Ref: Oroxylin A improves the sensitivity of HT-29 human colon cancer cells to 5-FU through modulation of the COX-2 signaling pathway. PMID: 22607196 Ref: High-resolution melting assay (HRMA) is a simple and sensitive stool-based DNA Test for the detection of mutations in colorectal neoplasms. PMID: 22609129 Ref: Development of ulcerative colitis and its associated colorectal neoplasia as a model of the organ-specific chronic inflammation-carcinoma sequence. PMID: 22612505 Ref: Curcumin induces permanent growth arrest of human colon cancer cells: link between senescence and autophagy. PMID: 22613224 Ref: Systems biology approach to identify gene network signatures for colorectal cancer. PMID: 22629282 Ref: The anticancer effect of saffron in two p53 isogenic colorectal cancer cell lines. PMID: 22640402 Ref: MAPK14/p38alpha confers irinotecan resistance to TP53-defective cells by inducing survival autophagy. PMID: 22647487 Ref: Direct molecular interactions between HMGB1 and TP53 in colorectal cancer. PMID: 22647615 Ref: 2'-Hydroxyflavanone induces apoptosis through Egr-1 involving expression of Bax, p21, and NAG-1 in colon cancer cells. PMID: 22648623 Ref: Pharmacogenomic profiling and pathway analyses identify MAPK-dependent migration as an acute response to SN38 in p53 null and p53-mutant colorectal cancer cells. PMID: 22665525 Ref: Comparative genomic analysis of primary versus metastatic colorectal carcinomas. PMID: 22665543 Ref: Microsatellite instability testing in Korean patients with colorectal cancer. PMID: 22669410 Ref: Hypermethylation of the 5' CpG island of the p14ARF flanking exon 1beta in human colorectal cancer displaying a restricted pattern of p53 overexpression concomitant with increased MDM2 expression. PMID: 22703554 Ref: Caveolin-1 increases aerobic glycolysis in colorectal cancers by stimulating HMGA1-mediated GLUT3 transcription. PMID: 22706202 Ref: Digital detection of multiple minority mutants in stool DNA for noninvasive colorectal cancer diagnosis. PMID: 22715805 Ref: Chloroquine enhances the chemotherapeutic activity of 5-fluorouracil in a colon cancer cell line via cell cycle alteration. PMID: 22716215 Ref: 6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest. PMID: 22719783 Ref: Anti-proliferative effect of an analogue of the LL-37 peptide in the colon cancer derived cell line HCT116 p53+/+ and p53-/-. PMID: 22736062 Ref: Cross-regulation of protein stability by p53 and nuclear receptor SHP. PMID: 22737255 Ref: Polymorphisms in TP53 and MDM2 contribute to higher risk of colorectal cancer in Chinese population: a hospital-based, case-control study. PMID: 22744426 Ref: STAT3 repressed USP7 expression is crucial for colon cancer development. PMID: 22750444 Ref: A significant role of lipogenic enzymes in colorectal cancer. PMID: 22753716 Ref: Domain landscapes of somatic mutations in cancer. PMID: 22759657 Ref: The pattern of epidermal growth factor receptor variation with disease progression and aggressiveness in colorectal cancer depends on tumor location. PMID: 22783405 Ref: C1B domain peptide of protein kinase Cgamma significantly suppresses growth of human colon cancer cells in vitro and in an in vivo mouse xenograft model through induction of cell cycle arrest and apoptosis. PMID: 22785210 Ref: Cisplatin-induced chemoresistance in colon cancer cells involves FXR-dependent and FXR-independent up-regulation of ABC proteins. PMID: 22800197 Ref: N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents. PMID: 22801474 Ref: The role of serotonin and p53 status in the radiation-induced bystander effect. PMID: 22803606 Ref: Comprehensive molecular characterization of human colon and rectal cancer. PMID: 22810696 Ref: In vitro and in vivo anti-colon cancer effects of Garcinia mangostana xanthones extract. PMID: 22818000 Ref: Genomic CGH-assessed structural DNA alterations in rectal carcinoma as related to local recurrence following primary operation for cure. PMID: 22825718 Ref: A comprehensive characterization of genome-wide copy number aberrations in colorectal cancer reveals novel oncogenes and patterns of alterations. PMID: 22860045 Ref: Prohibitin attenuates colitis-associated tumorigenesis in mice by modulating p53 and STAT3 apoptotic responses. PMID: 22869582 Ref: MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame. PMID: 22870278 Ref: CAV1/caveolin 1 enhances aerobic glycolysis in colon cancer cells via activation of SLC2A3/GLUT3 transcription. PMID: 22874559 Ref: The utility of diagnostic biopsy specimens for predictive molecular testing in colorectal cancer. PMID: 22882224 Ref: Apoptotic-like death occurs through a caspase-independent route in colon carcinoma cells undergoing mitotic catastrophe. PMID: 22885806 Ref: Mitomycin C potentiates TRAIL-induced apoptosis through p53-independent upregulation of death receptors: evidence for the role of c-Jun N-terminal kinase activation. PMID: 22895172 Ref: Histomorphologic and molecular features of pouch and peripouch adenocarcinoma: a comparison with ulcerative colitis-associated adenocarcinoma. PMID: 22895272 Ref: Irinotecan induces senescence and apoptosis in colonic cells in vitro. PMID: 22898888 Ref: No association between the USP7 gene polymorphisms and colorectal cancer in the Chinese Han population. PMID: 22901115 Ref: Pilot study of the sensitivity and specificity of the DNA integrity assay for stool-based detection of colorectal cancer in Malaysian patients. PMID: 22901138 Ref: c-Src antisense complexed with PAMAM denderimes decreases of c-Src expression and EGFR-dependent downstream genes in the human HT-29 colon cancer cell line. PMID: 22901200 Ref: Human papilloma virus 16 E6 oncoprotein associated with p53 inactivation in colorectal cancer. PMID: 22912557 Ref: Non-digestible fraction of beans (Phaseolus vulgaris L.) modulates signalling pathway genes at an early stage of colon cancer in Sprague-Dawley rats. PMID: 22916810 Ref: Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors. PMID: 22922338 Ref: The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep? PMID: 22927544 Ref: High-mobility group A1 protein inhibits p53-mediated intrinsic apoptosis by interacting with Bcl-2 at mitochondria. PMID: 22932725 Ref: Identification of HEXIM1 as a positive regulator of p53. PMID: 22948151 Ref: Induction of apoptosis by 7-piperazinethylchrysin in HCT-116 human colon cancer cells. PMID: 22948973 Ref: Limitations of tissue micro array in Duke's B colon cancer. PMID: 22958290 Ref: Osteopontin is overexpressed in colorectal carcinoma and is correlated with P53 by immunohistochemistry. PMID: 22969940 Ref: EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma. PMID: 22975375 Ref: Magnolol-induced apoptosis in HCT-116 colon cancer cells is associated with the AMP-activated protein kinase signaling pathway. PMID: 22975518 Ref: Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage. PMID: 22989419 Ref: The prognostic value of the immunohistochemical aspects of tumor suppressor genes p53, bcl-2, PTEN and nuclear proliferative antigen Ki-67 in resected colorectal carcinoma. PMID: 22990545 Ref: Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells. PMID: 22992837 Ref: Expression of p53 and Ki-67 as prognostic factors for survival of men with colorectal cancer. PMID: 22993345 Ref: Molecular dissection of premalignant colorectal lesions reveals early onset of the CpG island methylator phenotype. PMID: 22995252 Ref: Role of FBXL20 in human colorectal adenocarcinoma. PMID: 23023584 Ref: The inhibition of autophagy sensitises colon cancer cells with wild-type p53 but not mutant p53 to topotecan treatment. PMID: 23024792 Ref: MAP kinase genes and colon and rectal cancer. PMID: 23027623 Ref: Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. PMID: 23034650 Ref: Combined effects of storage and processing on the bioactive compounds and pro-apoptotic properties of color-fleshed potatoes in human colon cancer cells. PMID: 23039105 Ref: P53 status as a predictive biomarker for patients receiving neoadjuvant radiation-based treatment: a meta-analysis in rectal cancer. PMID: 23049793 Ref: A LIN28B polymorphism predicts for colon cancer survival. PMID: 23052130 Ref: Meeting the biologic challenge of colorectal metastases. PMID: 23053740 Ref: FBN2 methylation is detected in the serum of colorectal cancer patients with hepatic metastasis. PMID: 23060561 Ref: Novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, MHY-449, induces apoptosis and cell cycle arrest in HCT116 human colon cancer cells. PMID: 23064444 Ref: Roles of miRNA in the initiation and development of colorectal carcinoma. PMID: 23092344 Ref: Crocetin induces cytotoxicity in colon cancer cells via p53-independent mechanisms. PMID: 23098467 Ref: Abnormal expression of GADD45B in human colorectal carcinoma. PMID: 23110778 Ref: Bax is essential for death receptor-mediated apoptosis in human colon cancer cells. PMID: 23113596 Ref: Prognostic and predictive factors in colorectal cancer. PMID: 23116828 Ref: MiR-186, miR-216b, miR-337-3p, and miR-760 cooperatively induce cellular senescence by targeting alpha subunit of protein kinase CKII in human colorectal cancer cells. PMID: 23137536 Ref: Non-thermal Plasma Causes p53-Dependent Apoptosis in Human Colon Carcinoma Cells. PMID: 23150806 Ref: Predictive role of thymidine phosphorylase expression in patients with colorectal cancer and its association with angiogenesis-related proteins and extracellular matrix components. PMID: 23160694 Ref: Transcriptional regulation of thymine DNA glycosylase (TDG) by the tumor suppressor protein p53. PMID: 23165212 Ref: Combined EGFR and c-Src antisense oligodeoxynucleotides encapsulated with PAMAM Denderimers inhibit HT-29 colon cancer cell proliferation. PMID: 23167414 Ref: Quinacrine-mediated autophagy and apoptosis in colon cancer cells is through a p53- and p21-dependent mechanism. PMID: 23193914 Ref: Reactive oxygen species mediate Cr(VI)-induced S phase arrest through p53 in human colon cancer cells. PMID: 23216635 Ref: Macrophage inhibitory cytokine-1: a review of its pleiotropic actions in cancer. PMID: 23220850 Ref: Induction of apoptosis of SW480 human colon cancer cells by (-)-epicatechin isolated from Bulnesia sarmienti. PMID: 23225437 Ref: [Clinical significance of serum anti-p53 antibody measurement for colorectal cancer]. PMID: 23268012 Ref: [The clinical significance of serum anti-p53 antibody as a monitoring marker in colorectal cancer]. PMID: 23268013 Ref: [Genetic and epigenetic changes in colorectal cancer and genetic testing for personalized medicine]. PMID: 23323463 Ref: [A study on the mutation of P53 and K-ras gene in colorectal adenomas and colorectal carcinomas]. PMID: 23387205 Ref: Analysis of PTEN, VEGF, HER2 and P53 status in determining colorectal cancer benefit from bevacizumab therapy. PMID: 23464465 Ref: Mutation Analysis of TP53 Tumor Suppressor Gene in Colorectal Cancer in Patients from Iran (Kerman Province). PMID: 23492839 Ref: Selective growth inhibition by glycogen synthase kinase-3 inhibitors in tumorigenic HeLa hybrid cells is mediated through NF-kappaB-dependent GLUT3 expression. PMID: 23552737 Ref: Molecular analysis and anticancer properties of two identified isolates, Fusarium solani and Emericella nidulans isolated from Wady El-Natron soil in Egypt against Caco-2 (ATCC) cell line. PMID: 23569862 Ref: Mechanisms involved in the cytotoxic effects of berberine on human colon cancer HCT-8 cells. PMID: 23682426 Ref: Relationship Between Dual-Time Point FDG PET and Immunohistochemical Parameters in Preoperative Colorectal Cancer: Preliminary Study. PMID: 24900032 |
Ref: DNA damaging properties of single walled carbon nanotubes in human colon carcinoma cells. PMID: 22007624 Ref: Cladosporol a stimulates G1-phase arrest of the cell cycle by up-regulation of p21(waf1/cip1) expression in human colon carcinoma HT-29 cells. PMID: 22025467 Ref: A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo. PMID: 22292771 Ref: Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells. PMID: 22430210 Ref: Inhibition of autophagy and tumor growth in colon cancer by miR-502. PMID: 22580605 Ref: Curcumin inhibits proliferation and induces apoptosis of human colorectal cancer cells by activating the mitochondria apoptotic pathway. PMID: 22628241 Ref: The role of autophagic cell death and apoptosis in irinotecan-treated p53 null colon cancer cells. PMID: 22721392 Ref: An alternative pathway in colorectal carcinogenesis based on the mismatch repair system and p53 expression in Korean patients with sporadic colorectal cancer. PMID: 22732839 Ref: Identification of novel driver tumor suppressors through functional interrogation of putative passenger mutations in colorectal cancer. PMID: 22753261 Ref: Methylselenol, a selenium metabolite, modulates p53 pathway and inhibits the growth of colon cancer xenografts in Balb/c mice. PMID: 22841391 Ref: Ursolic acid induces cell death and modulates autophagy through JNK pathway in apoptosis-resistant colorectal cancer cells. PMID: 22841540 Ref: Relationship between MDM2 and p53 alterations in colorectal cancer and their involvement and prognostic value in the Tunisian population. PMID: 22914606 Ref: A bioactive probe of the oxidative pentose phosphate cycle: novel strategy to reverse radioresistance in glucose deprived human colon cancer cells. PMID: 22926048 Ref: Transcriptional profiling identifies genes induced by hepatocyte-derived extracellular matrix in metastatic human colorectal cancer cell lines. PMID: 22930170 Ref: Addition of interferon-alpha to the p53-SLP(R) vaccine results in increased production of interferon-gamma in vaccinated colorectal cancer patients: a phase I/II clinical trial. PMID: 22948952 Ref: PIK3CA overexpression is a possible prognostic factor for favorable survival in ovarian clear cell carcinoma. PMID: 22955107 Ref: Possible predictive value of maspin expression in colorectal cancer. PMID: 22963136 Ref: PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage. PMID: 22975685 Ref: The rs6983267 SNP is associated with MYC transcription efficiency, which promotes progression and worsens prognosis of colorectal cancer. PMID: 22976378 Ref: HSP27 expression in primary colorectal cancers is dependent on mutation of KRAS and PI3K/AKT activation status and is independent of TP53. PMID: 22982087 Ref: Diffusion-weighted MR imaging in liver metastases of colorectal cancer: reproducibility and biological validation. PMID: 23001604 Ref: Mathematical model of colitis-associated colon cancer. PMID: 23026764 Ref: Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner. PMID: 23072722 Ref: Association between genomic alterations and metastatic behavior of colorectal cancer identified by array-based comparative genomic hybridization. PMID: 23073979 Ref: Resveratrol depletes mitochondrial DNA and inhibition of autophagy enhances resveratrol-induced caspase activation. PMID: 23088850 Ref: Roles of miRNA in the initiation and development of colorectal carcinoma. PMID: 23092337 Ref: Gene polymorphisms predict toxicity to neoadjuvant therapy in patients with rectal cancer. PMID: 23096768 Ref: Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924. PMID: 23100467 Ref: UbcH10 overexpression in human lung carcinomas and its correlation with EGFR and p53 mutational status. PMID: 23102841 Ref: Cytoplasmic mislocalization of overexpressed FOXF1 is associated with the malignancy and metastasis of colorectal adenocarcinomas. PMID: 23103611 Ref: 5-Fluorouracil signaling through a calcium-calmodulin-dependent pathway is required for p53 activation and apoptosis in colon carcinoma cells. PMID: 23108402 Ref: Tumor regression by phenethyl isothiocyanate involves DDB2. PMID: 23114715 Ref: Relationship between the expression of the extracellular matrix genes SPARC, SPP1, FN1, ITGA5 and ITGAV and clinicopathological parameters of tumor progression and colorectal cancer dissemination. PMID: 23128103 Ref: Cancer cell resistance to aurora kinase inhibitors: identification of novel targets for cancer therapy. PMID: 23151231 Ref: Biopsy specimens obtained 7 days after starting chemoradiotherapy (CRT) provide reliable predictors of response to CRT for rectal cancer. PMID: 23158058 Ref: Use of multivariate analysis to suggest a new molecular classification of colorectal cancer. PMID: 23165447 Ref: Early detection of cancer in the general population: a blinded case-control study of p53 autoantibodies in colorectal cancer. PMID: 23169294 Ref: Hedgehog Gli3 activator signal augments tumorigenicity of colorectal cancer via upregulation of adherence-related genes. PMID: 23176625 Ref: A genetic variant in the promoter region of miR-34b/c is associated with a reduced risk of colorectal cancer. PMID: 23183747 Ref: Upregulation of the antiapoptotic factor Livin contributes to cisplatin resistance in colon cancer cells. PMID: 23188704 Ref: Kras mutations and p53 overexpression in pseudomyxoma peritonei: association with phenotype and prognosis. PMID: 23199549 Ref: microRNA-7 is a novel inhibitor of YY1 contributing to colorectal tumorigenesis. PMID: 23208495 Ref: Multiplicity and molecular heterogeneity of colorectal carcinomas in individuals with serrated polyposis. PMID: 23211288 Ref: p21(WAF(1)/C(1)P(1)) deficiency induces mitochondrial dysfunction in HCT116 colon cancer cells. PMID: 23211592 Ref: Prognostic relevance of BRD7 expression in colorectal carcinoma. PMID: 23215825 Ref: Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway. PMID: 23246487 Ref: Identification of miRNA-miRNA synergistic relationships in colorectal cancer. PMID: 23246904 Ref: The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe? PMID: 23246969 Ref: MicroRNA-218 inhibits cell cycle progression and promotes apoptosis in colon cancer by downregulating BMI1 polycomb ring finger oncogene. PMID: 23255074 Ref: High-mobility group box 2 (HMGB2) modulates radioresponse and is downregulated by p53 in colorectal cancer cell. PMID: 23255232 Ref: Anticancer potential of an ethanol extract of Asiasari radix against HCT-116 human colon cancer cells in vitro. PMID: 23255939 Ref: Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymerase beta. PMID: 23266186 Ref: Different patterns of DNA methylation of the two distinct O6-methylguanine-DNA methyltransferase (O6-MGMT) promoter regions in colorectal cancer. PMID: 23271133 Ref: Effect of genomic instability and mutations on the signaling pathways in colon cancer cells. PMID: 23277013 Ref: Dysregulation and crosstalk of cellular signaling pathways in colon carcinogenesis. PMID: 23287077 Ref: The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest. PMID: 23308284 Ref: Cohypermethylation of p14 in combination with CADM1 or DCC as a recurrence-related prognostic indicator in stage I esophageal squamous cell carcinoma. PMID: 23310950 Ref: bis-Dehydroxy-Curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy. PMID: 23326480 Ref: Role of rho-kinase gene polymorphisms and protein expressions in colorectal cancer development. PMID: 23328676 Ref: Suppression of Src/ERK and GSK-3/beta-catenin signaling by pinosylvin inhibits the growth of human colorectal cancer cells. PMID: 23333577 Ref: Associations of beta-catenin alterations and MSI screening status with expression of key cell cycle regulating proteins and survival from colorectal cancer. PMID: 23337059 Ref: 5-Geranyloxy-7-methoxycoumarin inhibits colon cancer (SW480) cells growth by inducing apoptosis. PMID: 23345169 Ref: Stool DNA testing for the detection of colorectal neoplasia in patients with inflammatory bowel disease. PMID: 23347191 Ref: Chromosome 16q loss--a genetic key to the understanding of breast carcinogenesis. PMID: 23348384 Ref: Tamoxifen magnifies therapeutic impact of ceramide in human colorectal cancer cells independent of p53. PMID: 23353700 Ref: Scutellaria barbata D. Don induces G1/S arrest via modulation of p53 and Akt pathways in human colon carcinoma cells. PMID: 23354912 Ref: Two initiation sites of early detection of colon cancer revealed by localization of pERK1/2 in the nuclei or in aggregates at the perinuclear region of the tumor cells. PMID: 23357054 Ref: Oleuropein, a secoiridoid derived from olive tree, inhibits the proliferation of human colorectal cancer cell through downregulation of HIF-1alpha. PMID: 23368925 Ref: microRNA-16 represses colorectal cancer cell growth in vitro by regulating the p53/survivin signaling pathway. PMID: 23380758 Ref: A case of syncronised hereditery nonpoliposis colorectal tumor with different hystopathological type and k-ras gene mutation: case report. PMID: 23390480 Ref: Regulation of the proliferation of colon cancer cells by compounds that affect glycolysis, including 3-bromopyruvate, 2-deoxyglucose and biguanides. PMID: 23393330 Ref: Thymidylate kinase: an old topic brings new perspectives. PMID: 23394555 Ref: Downregulation of anti-oncomirs miR-143/145 cluster occurs before APC gene aberration in the development of colorectal tumors. PMID: 23397547 Ref: Relationship between epithelial and stromal TRIM28 expression predicts survival in colorectal cancer patients. PMID: 23425061 Ref: Induction of apoptosis and suppression of ERCC1 expression by the potent amonafide analogue 8-c in human colorectal carcinoma cells. PMID: 23426174 Ref: Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects. PMID: 23429289 Ref: Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions. PMID: 23434653 Ref: Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling. PMID: 23441183 Ref: Management of stage II colon cancer - the use of molecular biomarkers for adjuvant therapy decision. PMID: 23446022 Ref: Socioeconomic status, p53 abnormalities, and colorectal cancer. PMID: 23450636 Ref: Autophagy and cellular senescence mediated by Sox2 suppress malignancy of cancer cells. PMID: 23451179 Ref: Anticancer activity of olive oil hydroxytyrosyl acetate in human adenocarcinoma Caco-2 cells. PMID: 23452288 Ref: Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. PMID: 23454242 Ref: Mutations in specific codons of the KRAS oncogene are associated with variable resistance to neoadjuvant chemoradiation therapy in patients with rectal adenocarcinoma. PMID: 23456389 Ref: The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer. PMID: 23456958 Ref: Xenogeneic human p53 DNA vaccination by electroporation breaks immune tolerance to control murine tumors expressing mouse p53. PMID: 23457640 Ref: Cytotoxic effect of (1-methyl-1H-imidazol-2-yl)-methanamine and its derivatives in Pt(II) complexes on human carcinoma cell lines: a comparative study with cisplatin. PMID: 23462712 Ref: Calcein-effluxing human colon cancer cells are enriched for self-renewal capacity and depend on beta-catenin. PMID: 23468473 Ref: Cytotoxic activity and apoptosis-inducing potential of di-spiropyrrolidino and di-spiropyrrolizidino oxindole andrographolide derivatives. PMID: 23472133 Ref: Synthesis and evaluation of an imidazole derivative-fluorescein conjugate. PMID: 23477941 Ref: Stabilization of MDA-7/IL-24 for colon cancer therapy. PMID: 23481022 Ref: Decrease of survivin, p53 and Bcl-2 expression in chemorefractory colorectal liver metastases may be predictive of radiosensivity radiosensivity after radioembolization with yttrium-90 resin microspheres. PMID: 23497522 Ref: Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer. PMID: 23512991 Ref: Silver-based nanoparticles induce apoptosis in human colon cancer cells mediated through p53. PMID: 23514434 Ref: ss-Catenin, Cox-2 and p53 immunostaining in colorectal adenomas to predict recurrence after endoscopic polypectomy. PMID: 23516071 Ref: Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target alpha5 integrin in colon cancer cells. PMID: 23523610 Ref: Alterations in K-ras, APC and p53-multiple genetic pathway in colorectal cancer among Indians. PMID: 23526092 Ref: Secreted recombinant P53 protein from Pichia pastoris is a useful antigen for detection of serum p53: autoantibody in patients with advanced colorectal adenocarcinoma. PMID: 23526366 Ref: KRAS, BRAF, and TP53 deep sequencing for colorectal carcinoma patient diagnostics. PMID: 23531339 Ref: Nucleophosmin 1, upregulated in adenomas and cancers of the colon, inhibits p53-mediated cellular senescence. PMID: 23536448 Ref: LncRNA loc285194 is a p53-regulated tumor suppressor. PMID: 23558749 Ref: p53 interferes with microtubule-stabilizing agent-induced apoptosis in prostate and colorectal cancer cells. PMID: 23563592 Ref: Evaluation of apoptotic activity of new condensed pyrazole derivatives. PMID: 23568979 Ref: Prognostic role of p53 messenger ribonucleic acid expression in patients after curative resection for stage I to III colorectal cancer: association with colon cancer stem cell markers. PMID: 23571142 Ref: Downregulation of ATP-binding cassette subfamily C member 4 increases sensitivity to neoadjuvant radiotherapy for locally advanced rectal carcinoma. PMID: 23575399 Ref: Practical value of the new system for Maspin assessment, in colorectal cancer. PMID: 23581409 Ref: Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade. PMID: 23583370 Ref: Melanoidins isolated from heated potato fiber (Potex) affect human colon cancer cells growth via modulation of cell cycle and proliferation regulatory proteins. PMID: 23583803 Ref: Stage III & IV colon and rectal cancers share a similar genetic profile: a review of the Oregon Colorectal Cancer Registry. PMID: 23592171 Ref: alpha-Lipoic acid prevents p53 degradation in colon cancer cells by blocking NF-kappaB induction of RPS6KA4. PMID: 23599020 Ref: Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21). PMID: 23620673 Ref: Autophagy of cancer stem cells is involved with chemoresistance of colon cancer cells. PMID: 23624503 Ref: p53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2 suppression in colorectal cancer cells. PMID: 23624843 Ref: Inauhzin sensitizes p53-dependent cytotoxicity and tumor suppression of chemotherapeutic agents. PMID: 23633924 Ref: Over-expression of small ubiquitin-related modifier-1 and sumoylated p53 in colon cancer. PMID: 23640307 Ref: [Effect of cell cycle-related novel gene CACUL1 on the apoptosis of colorectal cancer cells in vitro]. PMID: 23643261 Ref: Normalization of serum p53 antibody levels in patients after curative resection for colorectal cancer. PMID: 23645779 Ref: Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint. PMID: 23649806 Ref: Expression and functions of galectin-7 in human and murine melanomas. PMID: 23658821 Ref: EVI1 targets DeltaNp63 and upregulates the cyclin dependent kinase inhibitor p21 independent of p53 to delay cell cycle progression and cell proliferation in colon cancer cells. PMID: 23665236 Ref: A case of late-onset Li-Fraumeni-like syndrome with unilateral breast cancer. PMID: 23667851 Ref: HIPK1 drives p53 activation to limit colorectal cancer cell growth. PMID: 23676219 Ref: A novel aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment. PMID: 23678290 Ref: Mutant p53 prolongs NF-kappaB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. PMID: 23680148 Ref: Antioxidants: friends or foe in prevention or treatment of cancer: the debate of the century. PMID: 23680455 Ref: Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells. PMID: 23686257 Ref: Curcumin induces apoptosis in human colorectal carcinoma (HCT-15) cells by regulating expression of Prp4 and p53. PMID: 23686430 Ref: Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value. PMID: 23700391 Ref: FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells. PMID: 23700428 Ref: Targeted sequencing of cancer-related genes in colorectal cancer using next-generation sequencing. PMID: 23700467 Ref: Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy. PMID: 23703384 Ref: Characterization and Prognostic Value of Mutations in Exons 5 and 6 of the p53 Gene in Patients with Colorectal Cancers in Central Iran. PMID: 23710310 Ref: Activation of AMP-activated protein kinase (AMPK) mediates plumbagin-induced apoptosis and growth inhibition in cultured human colon cancer cells. PMID: 23712032 Ref: Tumor suppressor functions of miR-133a in colorectal cancer. PMID: 23723074 Ref: Inhibition of GSK3B bypass drug resistance of p53-null colon carcinomas by enabling necroptosis in response to chemotherapy. PMID: 23729362 Ref: [Radiation-induced intracranial osteosarcoma after radiation for acute lymphocytic leukemia associated with Li-Fraumeni syndrome]. PMID: 23732761 Ref: Spectral histopathology of colon cancer tissue sections by Raman imaging with 532 nm excitation provides label free annotation of lymphocytes, erythrocytes and proliferating nuclei of cancer cells. PMID: 23733134 Ref: Genomic instability and colon carcinogenesis: from the perspective of genes. PMID: 23734346 Ref: Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer. PMID: 23739040 Ref: Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo. PMID: 23741060 Ref: Destruxins: fungal-derived cyclohexadepsipeptides with multifaceted anticancer and antiangiogenic activities. PMID: 23747344 Ref: Overexpression of hypoxia inducible factor-1 alpha is an independent risk factor for recurrence after curative resection of colorectal liver metastases. PMID: 23748663 Ref: 5-lipoxygenase antagonist therapy: a new approach towards targeted cancer chemotherapy. PMID: 23752617 Ref: Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells. PMID: 23754252 Ref: Cytotoxicity of 1,4-diamino-2-butanone, a putrescine analogue, to RKO cells: mechanism and redox imbalance. PMID: 23758064 Ref: Coumestrol induces senescence through protein kinase CKII inhibition-mediated reactive oxygen species production in human breast cancer and colon cancer cells. PMID: 23768371 Ref: Molecular classification of colorectal cancer: a dream that can become a reality. PMID: 23771065 Ref: A mechanistic study of the proapoptotic effect of tolfenamic acid: involvement of NF-kappaB activation. PMID: 23784084 Ref: Overexpression of RBBP6, alone or combined with mutant TP53, is predictive of poor prognosis in colon cancer. PMID: 23799110 Ref: Comparison of primarily diet-modifiable intestinal factors, connexin 43 and E-cadherin with TP53 and TGFB1 in colorectal cancer. PMID: 23803369 Ref: Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype. PMID: 23807779 Ref: [Effect of free and polymer carrier encapsulated doxorubicin towards HCT116 cells of human colorectal carcinoma]. PMID: 23808308 Ref: Ceragenin CSA-13 induces cell cycle arrest and antiproliferative effects in wild-type and p53 null mutant HCT116 colon cancer cells. PMID: 23817390 Ref: Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue. PMID: 23818604 Ref: Ribosomal protein S27-like in colorectal cancer: a candidate for predicting prognoses. PMID: 23826192 Ref: Cytotoxicity and modes of action of four Cameroonian dietary spices ethno-medically used to treat cancers: Echinops giganteus, Xylopia aethiopica, Imperata cylindrica and Piper capense. PMID: 23827757 Ref: ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis. PMID: 23831472 Ref: HSP90 Inhibitors, Geldanamycin and Radicicol, Enhance Fisetin-Induced Cytotoxicity via Induction of Apoptosis in Human Colonic Cancer Cells. PMID: 23840275 Ref: BRAF: a driver of the serrated pathway in colon cancer. PMID: 23845435 Ref: The influence of R substituents in triphenylphosphinegold(I) carbonimidothioates, Ph3PAu[SC(OR)=NPh] (R=Me, Et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways. PMID: 23850666 Ref: Epicatechin gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon cancer SW480 cells. PMID: 23859040 Ref: Dihydrotanshinone induces p53-independent but ROS-dependent apoptosis in colon cancer cells. PMID: 23871989 Ref: The role of p53 in combination radioimmunotherapy with 64Cu-DOTA-cetuximab and cisplatin in a mouse model of colorectal cancer. PMID: 23873478 Ref: Regulation of hypoxia-inducible factor 1alpha (HIF-1alpha) by lysophosphatidic acid is dependent on interplay between p53 and Kruppel-like factor 5. PMID: 23880760 Ref: Particled Mica, STB-HO has chemopreventive potential via G1 arrest, and inhibition of proliferation and vascular endothelial growth factor receptor 2 in HCT colorectal cancer cells. PMID: 23883349 Ref: Role of p53, Bax, p21, and DNA-PKcs in radiation sensitivity of HCT-116 cells and xenografts. PMID: 23889944 Ref: Mechanisms involved in the antiproliferative and proapoptotic effects of unsaponifiable fraction of extra virgin olive oil on HT-29 cancer cells. PMID: 23909736 Ref: Preparation, preliminary characterization and inhibitory effect on human colon cancer HT-29 cells of an acidic polysaccharide fraction from Stachys floridana Schuttl. ex Benth. PMID: 23911803 Ref: Current evidence on the relationship between SNP309 polymorphism in the MDM2 gene and colorectal cancer risk. PMID: 23912932 Ref: Clinical utility of anti-p53 auto-antibody: systematic review and focus on colorectal cancer. PMID: 23922463 Ref: Gene expression data reveal common pathways that characterize the unifocal nature of ovarian cancer. PMID: 23933223 Ref: Blastocystis sp. subtype 3 triggers higher proliferation of human colorectal cancer cells, HCT116. PMID: 23933809 Ref: Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing. PMID: 23934261 Ref: TP53 and let-7a micro-RNA regulate K-Ras activity in HCT116 colorectal cancer cells. PMID: 23936455 Ref: Human voltage-gated proton channel hv1: a new potential biomarker for diagnosis and prognosis of colorectal cancer. PMID: 23940591 Ref: Anti-cancer effect and apoptosis induction of cordycepin through DR3 pathway in the human colonic cancer cell HT-29. PMID: 23941773 Ref: PINCH expression in relation to radiation response in co-cultured colon cancer cells and in rectal cancer patients. 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PMID: 26336987 Ref: Cytotoxicity of selected Cameroonian medicinal plants and Nauclea pobeguinii towards multi-factorial drug-resistant cancer cells. PMID: 26341728 Ref: Hypoxia Promotes Synergy between Mitomycin C and Bortezomib through a Coordinated Process of Bcl-xL Phosphorylation and Mitochondrial Translocation of p53. PMID: 26354682 Ref: p53 controls colorectal cancer cell invasion by inhibiting the NF-kappaB-mediated activation of Fascin. PMID: 26362504 Ref: Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1. PMID: 26363315 Ref: Gypenosides Synergistically Enhances the Anti-Tumor Effect of 5-Fluorouracil on Colorectal Cancer In Vitro and In Vivo: A Role for Oxidative Stress-Mediated DNA Damage and p53 Activation. PMID: 26368019 Ref: High Prevalence and Clinical Relevance of Genes Affected by Chromosomal Breaks in Colorectal Cancer. PMID: 26375816 Ref: A survey of tandem repeat instabilities and associated gene expression changes in 35 colorectal cancers. PMID: 26376692 Ref: Tumour-promoting role of SOCS1 in colorectal cancer cells. PMID: 26391193 Ref: Synthetic Bichalcone TSWU-BR23 Induces Apoptosis of Human Colon Cancer HT-29 Cells by p53-Mediated Mitochondrial Oligomerization of BAX/BAK and Lipid Raft Localization of CD95/FADD. PMID: 26408703 Ref: Cellular signaling pathways implicated in metastasis of colorectal cancer and the associated targeted agents. PMID: 26414153 Ref: TP53 codon 72 Arg/Arg polymorphism is associated with a higher risk for inflammatory bowel disease development. PMID: 26420962 Ref: TP53 Mutational Status and Prediction of Benefit from Adjuvant 5-Fluorouracil in Stage III Colon Cancer Patients. PMID: 26425688 Ref: Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design. PMID: 26437226 Ref: Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets. PMID: 26446703 Ref: Analysis of K-ras codon 12 and TP53 mutations in patients with advanced colorectal carcinoma. PMID: 26449693 Ref: PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms. PMID: 26452133 Ref: Deregulation of miR-126 expression in colorectal cancer pathogenesis and its clinical significance. PMID: 26455548 Ref: The silence of p66(Shc) in HCT8 cells inhibits the viability via PI3K/AKT/Mdm-2/p53 signaling pathway. PMID: 26464652 Ref: Large Bowel Genetic Background and Inflammatory Processes in Carcinogenesis--Systematic Review. PMID: 26469098 Ref: Role of retinoids in the prevention and treatment of colorectal cancer. PMID: 26483874 Ref: Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis. PMID: 26485768 Ref: Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. PMID: 26492315 Ref: Identification of O-Linked Glycoproteins Binding to the Lectin Helix pomatia Agglutinin as Markers of Metastatic Colorectal Cancer. PMID: 26495974 Ref: Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents. PMID: 26501353 Ref: The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death. PMID: 26510776 Ref: Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics. PMID: 26513173 Ref: Nucleocytoplasmic Translocation of UBXN2A Is Required for Apoptosis during DNA Damage Stresses in Colon Cancer Cells. PMID: 26516353 Ref: Mutational profiling of colorectal cancers with microsatellite instability. PMID: 26517354 Ref: Editorial. PMID: 26520390 Ref: Identification of a novel compound (beta-sesquiphellandrene) from turmeric (Curcuma longa) with anticancer potential: comparison with curcumin. PMID: 26521943 Ref: [Fecal Biomarker for Colorectal Cancer Diagnosis]. PMID: 26524859 Ref: Cytotoxicity of three naturally occurring flavonoid derived compounds (artocarpesin, cycloartocarpesin and isobavachalcone) towards multi-factorial drug-resistant cancer cells. PMID: 26547532 Ref: A new way to target p53-defective colorectal cancer. PMID: 26549592 Ref: MIR517C inhibits autophagy and the epithelial-to-mesenchymal (-like) transition phenotype in human glioblastoma through KPNA2-dependent disruption of TP53 nuclear translocation. PMID: 26553592 Ref: Novel beta-Carboline/Hydroxamic Acid Hybrids Targeting Both Histone Deacetylase and DNA Display High Anticancer Activity via Regulation of the p53 Signaling Pathway. PMID: 26555243 Ref: Radiation and SN38 treatments modulate the expression of microRNAs, cytokines and chemokines in colon cancer cells in a p53-directed manner. PMID: 26556872 Ref: Regorafenib with a fluoropyrimidine for metastatic colorectal cancer after progression on multiple 5-FU-containing combination therapies and regorafenib monotherapy. PMID: 26561209 Ref: Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells. PMID: 26580615 Ref: Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth. PMID: 26586936 Ref: Anticancer bioactive peptides suppress human colorectal tumor cell growth and induce apoptosis via modulating the PARP-p53-Mcl-1 signaling pathway. PMID: 26592508 Ref: Antitumor Activity of Americanin A Isolated from the Seeds of Phytolacca americana by Regulating the ATM/ATR Signaling Pathway and the Skp2-p27 Axis in Human Colon Cancer Cells. PMID: 26595875 Ref: Metformin Radiosensitizes p53-Deficient Colorectal Cancer Cells through Induction of G2/M Arrest and Inhibition of DNA Repair Proteins. PMID: 26599019 Ref: Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action. PMID: 26599982 Ref: Functional Characterization and Drug Response of Freshly Established Patient-Derived Tumor Models with CpG Island Methylator Phenotype. PMID: 26618628 Ref: Relationship among mismatch repair deficiency, CDX2 loss, p53 and E-cadherin in colon carcinoma and suitability of using a double panel of mismatch repair proteins by immunohistochemistry. PMID: 26619103 Ref: Mechanism of Action of Nigella sativa on Human Colon Cancer Cells: the Suppression of AP-1 and NF-kappaB Transcription Factors and the Induction of Cytoprotective Genes. PMID: 26625825 Ref: Anticolorectal cancer effects and pharmacokinetic application of 2, 2-Bis [4-(4-amino-3-hydroxyphenoxy) phenyl] adamantane. PMID: 26628962 Ref: ROS/p38/p53/Puma signaling pathway is involved in emodin-induced apoptosis of human colorectal cancer cells. PMID: 26629030 Ref: Adenovirus-Mediated E2F-1 Gene Transfer Augments Gemcitabine-Induced Apoptosis in Human Colon Cancer Cells. PMID: 26642705 Ref: Resveratrol elicits anti-colorectal cancer effect by activating miR-34c-KITLG in vitro and in vivo. PMID: 26674205 Ref: Fulvic Acid Attenuates Resistin-Induced Adhesion of HCT-116 Colorectal Cancer Cells to Endothelial Cells. PMID: 26690142 Ref: Aberrant DNA methylation profiles of inherited and sporadic colorectal cancer. PMID: 26697123 Ref: Interrupted E2F1-miR-34c-SCF negative feedback loop by hyper-methylation promotes colorectal cancer cell proliferation. PMID: 26704889 Ref: Polymorphisms of cell cycle regulator genes CCND1 G870A and TP53 C215G: Association with colorectal cancer susceptibility risk in a Malaysian population. PMID: 26722315 Ref: Circulating DNA and its methylation level in inflammatory bowel disease and related colon cancer. PMID: 26722606 Ref: Changes in immunoexpression of p53, Ki-67, Ets-1, APAF-1 and PTEN in serrated and conventional colon adenomas. PMID: 26743285 Ref: [Total Pelvic Exenteration for Local Recurrence of Rectal Cancer Appearing 12 Years after Curative Operation--A Case Report]. PMID: 26805356 Ref: p53 Configures the G2/M Arrest Response of Nucleostemin-Deficient Cells. PMID: 26835157 Ref: The Significance of Combined Measurement of p53 Antibody and other Tumor Markers for Colorectal Cancer after Curative Resection. PMID: 26897942 Ref: The Development Of RRx-001, A Novel Nitric-Oxide-Mediated Epigenetically Active Anticancer Agent. PMID: 28162292 |
Ref: The proto-oncogene PBF binds p53 and is associated with prognostic features in colorectal cancer. PMID: 25408419 Ref: mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation. PMID: 25867072 Ref: NY-ESO-1 autoantibody as a tumor-specific biomarker for esophageal cancer: screening in 1969 patients with various cancers. PMID: 25906289 Ref: H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK. PMID: 25961932 Ref: Germline and somatic genetic predictors of pathological response in neoadjuvant settings of rectal and esophageal cancers: systematic review and meta-analysis. PMID: 26122021 Ref: Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. PMID: 26152521 Ref: Serrated tubulovillous adenoma of the large intestine. PMID: 26212352 Ref: Tankyrase Inhibition Blocks Wnt/beta-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer. PMID: 26224873 Ref: High Ki67 expression is an independent good prognostic marker in colorectal cancer. PMID: 26281861 Ref: CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) and P53 mutation pattern in sporadic colorectal cancer. PMID: 26314856 Ref: Loss of H2Bub1 Expression is Linked to Poor Prognosis in Nodal Negative Colorectal Cancers. PMID: 26347467 Ref: RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies. PMID: 26350096 Ref: A phosphomimetic mutant of RelA/p65 at Ser536 induces apoptosis and senescence: An implication for tumor-suppressive role of Ser536 phosphorylation. PMID: 26375985 Ref: Anticancer Opportunity Created by Loss of Tumor Suppressor Genes. PMID: 26376693 Ref: LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner. PMID: 26400164 Ref: Adenoma development in familial adenomatous polyposis and MUTYH-associated polyposis: somatic landscape and driver genes. PMID: 26414517 Ref: ROBO1 deletion as a novel germline alteration in breast and colorectal cancer patients. PMID: 26427657 Ref: Clinicopathologic features of gastric cancer with synchronous and metachronous colorectal cancer in Korea: are microsatellite instability and p53 overexpression useful markers for predicting colorectal cancer in gastric cancer patients? PMID: 26445944 Ref: Purification, partial characterization and antitumor effect of an exopolysaccharide from Rhizopus nigricans. PMID: 26449531 Ref: Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas. PMID: 26451011 Ref: Mutation Spectra of Common Cancer-Associated Genes in Different Phenotypes of Colorectal Carcinoma Without Distant Metastasis. PMID: 26471487 Ref: mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition. PMID: 26471831 Ref: DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53. PMID: 26494468 Ref: Crataegus azarolus Leaves Induce Antiproliferative Activity, Cell Cycle Arrest, and Apoptosis in Human HT-29 and HCT-116 Colorectal Cancer Cells. PMID: 26495895 Ref: Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer. PMID: 26506418 Ref: Genetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway. PMID: 26510091 Ref: Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy. PMID: 26517689 Ref: Next-Generation Sequencing of Matched Primary and Metastatic Rectal Adenocarcinomas Demonstrates Minimal Mutation Gain and Concordance to Colonic Adenocarcinomas. PMID: 26536055 Ref: Evaluation of a 5-Marker Blood Test for Colorectal Cancer Early Detection in a Colorectal Cancer Screening Setting. PMID: 26561557 Ref: CRISPR-Cas9-based target validation for p53-reactivating model compounds. PMID: 26595461 Ref: Aspirin acetylates wild type and mutant p53 in colon cancer cells: identification of aspirin acetylated sites on recombinant p53. PMID: 26596838 Ref: Contribution of rare germline copy number variations and common susceptibility loci in Lynch syndrome patients negative for mutations in the mismatch repair genes. PMID: 26620301 Ref: Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID: 26634371 Ref: Signature miRNAs in colorectal cancers were revealed using a bias reduction small RNA deep sequencing protocol. PMID: 26646696 Ref: Genetic heterogeneity in synchronous colorectal cancers impacts genotyping approaches and therapeutic strategies. PMID: 26650777 Ref: Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway. PMID: 26666750 Ref: Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis. PMID: 26669864 Ref: Guarana a Caffeine-Rich Food Increases Oxaliplatin Sensitivity of Colorectal HT-29 Cells by Apoptosis Pathway Modulation. PMID: 26673759 Ref: Identification of the TP53-induced glycolysis and apoptosis regulator in various stages of colorectal cancer patients. PMID: 26675982 Ref: Novel 1,5-diphenyl-6-substituted 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones induced apoptosis in RKO colon cancer cells. PMID: 26677729 Ref: Potential role of TRIM3 as a novel tumour suppressor in colorectal cancer (CRC) development. PMID: 26691157 Ref: Expression of the apoptosis repressor with caspase recruitment domain (ARC) in liver metastasis of colorectal cancer and its correlation with DNA mismatch repair proteins and p53. PMID: 26721253 Ref: Synthesis and Optimization of New 3,6-Disubstitutedindole Derivatives and Their Evaluation as Anticancer Agents Targeting the MDM2/MDMx Complex. PMID: 26726742 Ref: Mieap-regulated mitochondrial quality control is frequently inactivated in human colorectal cancer. PMID: 26727575 Ref: Maslinic Acid, a Natural Triterpene, Induces a Death Receptor-Mediated Apoptotic Mechanism in Caco-2 p53-Deficient Colon Adenocarcinoma Cells. PMID: 26751572 Ref: Arginine starvation in colorectal carcinoma cells: Sensing, impact on translation control and cell cycle distribution. PMID: 26751966 Ref: Integrated analysis of DNA methylation and mutations in esophageal squamous cell carcinoma. PMID: 26756304 Ref: Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers. PMID: 26764183 Ref: Deregulated expression of cryptochrome genes in human colorectal cancer. PMID: 26768731 Ref: Chidamide and 5-flurouracil show a synergistic antitumor effect on human colon cancer xenografts in nude mice. PMID: 26774139 Ref: Imperatorin exhibits anticancer activities in human colon cancer cells via the caspase cascade. PMID: 26794238 Ref: Study of Arsenic Sulfide in Solid Tumor Cells Reveals Regulation of Nuclear Factors of Activated T-cells by PML and p53. PMID: 26795951 Ref: Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases. PMID: 26797410 Ref: Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis. PMID: 26807433 Ref: Effects of autophagy regulation of tumor-associated macrophages on radiosensitivity of colorectal cancer cells. PMID: 26821367 Ref: Decreasing CNPY2 Expression Diminishes Colorectal Tumor Growth and Development through Activation of p53 Pathway. PMID: 26835537 Ref: microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis. PMID: 26840028 Ref: Ribosomal protein S15A promotes malignant transformation and predicts poor outcome in colorectal cancer through misregulation of p53 signaling pathway. PMID: 26847263 Ref: Nitidine chloride inhibits proliferation and induces apoptosis in colorectal cancer cells by suppressing the ERK signaling pathway. PMID: 26847477 Ref: Piperlongumine exerts cytotoxic effects against cancer cells with mutant p53 proteins at least in part by restoring the biological functions of the tumor suppressor. PMID: 26848023 Ref: Thymoquinone from Nigella sativa Seeds Promotes the Antitumor Activity of Noncytotoxic Doses of Topotecan in Human Colorectal Cancer Cells in Vitro. PMID: 26848703 Ref: Radiosensitisation of human colorectal cancer cells by ruthenium(II) arene anticancer complexes. PMID: 26867983 Ref: Chromosomal microarray provides enhanced targetable gene aberration detection when paired with next generation sequencing panel in profiling lung and colorectal tumors. PMID: 26880400 Ref: Role of ribosomal protein mutations in tumor development (Review). PMID: 26892688 Ref: Association between the expression levels of TAZ, AXL and CTGF and clinicopathological parameters in patients with colon cancer. PMID: 26893723 Ref: miR-30e controls DNA damage-induced stress responses by modulating expression of the CDK inhibitor p21WAF1/CIP1 and caspase-3. PMID: 26895377 Ref: Mutation analysis of 13 driver genes of colorectal cancer-related pathways in Taiwanese patients. PMID: 26900293 Ref: Expression analysis and association of RBBP6 with apoptosis in colon cancers. PMID: 26905308 Ref: Prospective evaluation of 64 serum autoantibodies as biomarkers for early detection of colorectal cancer in a true screening setting. PMID: 26909861 Ref: Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis. PMID: 26913956 Ref: Development of a novel multiplex beads-based assay for autoantibody detection for colorectal cancer diagnosis. PMID: 26915739 Ref: Three-year monitoring of serum p53 antibody during chemotherapy and surgery for stage IV rectal cancer. PMID: 26919859 Ref: Impact of Cellular Genetic Make-up on Colorectal Cancer Cell Lines Response to Ellagic Acid: Implications of Small Interfering RNA. PMID: 26925673 Ref: Uc.206 regulates cell proliferation and apoptosis by targeting P53 in cervical cancer cells. PMID: 26925787 Ref: Adsorption according to the Langmuir-Freundlich model is the detection mechanism of the antigen p53 for early diagnosis of cancer. PMID: 26932233 Ref: Antitumor effects of calgranulin B internalized in human colon cancer cells. PMID: 26933915 Ref: SRJ09, a promising anticancer drug lead: Elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy. PMID: 26940565 Ref: Oroxylin A modulates mitochondrial function and apoptosis in human colon cancer cells by inducing mitochondrial translocation of wild-type p53. PMID: 26958937 Ref: Acquisition of Chemoresistance and Other Malignancy-related Features of Colorectal Cancer Cells Are Incremented by Ribosome-inactivating Stress. PMID: 26961878 Ref: Miltirone induced mitochondrial dysfunction and ROS-dependent apoptosis in colon cancer cells. PMID: 26969764 Ref: Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells. PMID: 26983878 Ref: Impact of KRAS, BRAF, PIK3CA, TP53 status and intraindividual mutation heterogeneity on outcome after liver resection for colorectal cancer metastases. PMID: 26991344 Ref: TP53 mutation at early stage of colorectal cancer progression from two types of laterally spreading tumors. PMID: 26991699 Ref: A novel dual-functioning ruthenium(II)-arene complex of an anti-microbial ciprofloxacin derivative - Anti-proliferative and anti-microbial activity. PMID: 26993079 Ref: Early signet ring cell carcinoma arising from colonic adenoma: the molecular profiling supports the adenoma-carcinoma sequence. PMID: 26997454 Ref: Deoxyelephantopin from Elephantopus scaber Inhibits HCT116 Human Colorectal Carcinoma Cell Growth through Apoptosis and Cell Cycle Arrest. PMID: 27007366 Ref: Design, synthesis and biological evaluation of novel benzimidazole-2-substituted phenyl or pyridine propyl ketene derivatives as antitumour agents. PMID: 27017265 Ref: Luffa echinata Roxb. Induced Apoptosis in Human Colon Cancer Cell (SW-480) in the Caspase-dependent Manner and Through a Mitochondrial Apoptosis Pathway. PMID: 27019558 Ref: KRAS and Combined KRAS/TP53 Mutations in Locally Advanced Rectal Cancer are Independently Associated with Decreased Response to Neoadjuvant Therapy. PMID: 27020587 Ref: Modeling the Etiology of p53-mutated Cancer Cells. PMID: 27022024 Ref: Systematic discovery of drug action mechanisms by an integrated chemical genomics approach: identification of functional disparities between azacytidine and decitabine. PMID: 27036028 Ref: Ultraconserved region-containing Transformer 2beta4 controls senescence of colon cancer cells. PMID: 27043659 Ref: The novel anthraquinone derivative IMP1338 induces death of human cancer cells by p53-independent S and G2/M cell cycle arrest. PMID: 27044842 Ref: Clinical value of intratumoral metabolic heterogeneity in [18F]FDG PET/CT for prediction of recurrence in patients with locally advanced colorectal cancer. PMID: 27045576 Ref: Genotoxicity of Cytolethal Distending Toxin (CDT) on Isogenic Human Colorectal Cell Lines: Potential Promoting Effects for Colorectal Carcinogenesis. PMID: 27047802 Ref: Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing. PMID: 27062928 Ref: Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease. PMID: 27063727 Ref: Cytotoxicity of 15 Cameroonian medicinal plants against drug sensitive and multi-drug resistant cancer cells. PMID: 27063984 Ref: Antitumor Activity of Spicatoside A by Modulation of Autophagy and Apoptosis in Human Colorectal Cancer Cells. PMID: 27064730 Ref: Comparative analysis of copy number variations in ulcerative colitis associated and sporadic colorectal neoplasia. PMID: 27080994 Ref: Mutation Yield of a 34-Gene Solid Tumor Panel in Community-Based Tumor Samples. PMID: 27084556 Ref: Establishment and characterization of HROC69 - a Crohn s related colonic carcinoma cell line and its matched patient-derived xenograft. PMID: 27087592 Ref: Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301. PMID: 27097159 Ref: Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest. PMID: 27098147 Ref: Validation and Application of a Custom-Designed Targeted Next-Generation Sequencing Panel for the Diagnostic Mutational Profiling of Solid Tumors. PMID: 27101000 Ref: Colorectal cancer cells display chaperone dependency for the unconventional prefoldin URI1. PMID: 27105489 Ref: Transcriptome profiling identifies genes and pathways deregulated upon floxuridine treatment in colorectal cancer cells harboring GOF mutant p53. PMID: 27114909 Ref: MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism. PMID: 27144434 Ref: Higher Initial DNA Damage and Persistent Cell Cycle Arrest after Carbon Ion Irradiation Compared to X-irradiation in Prostate and Colon Cancer Cells. PMID: 27148479 Ref: The prognostic significance of p53, Bax, Bcl-2 and cyclin E protein overexpression in colon cancer - an immunohistochemical study using the tissue microarray technique. PMID: 27151692 Ref: Driver Gene Mutations in Stools of Colorectal Carcinoma Patients Detected by Targeted Next-Generation Sequencing. PMID: 27155048 Ref: BRD7: a novel tumor suppressor gene in different cancers. PMID: 27158366 Ref: Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer. PMID: 27167335 Ref: Colorectal tumor molecular phenotype and miRNA: expression profiles and prognosis. PMID: 27198570 Ref: [Clinicopathological characteristics of colorectal carcinoma in the elderly]. PMID: 27215512 Ref: Nicotinamide Mononucleotide Adenylyl Transferase 2: A Promising Diagnostic and Therapeutic Target for Colorectal Cancer. PMID: 27218101 Ref: Harmal Extract Induces Apoptosis of HCT116 Human Colon Cancer Cells, Mediated by Inhibition of Nuclear Factor-kappaB and Activator Protein-1 Signaling Pathways and Induction of Cytoprotective Genes. PMID: 27221880 Ref: Screening for germline BRCA1, BRCA2, TP53 and CHEK2 mutations in families at-risk for hereditary breast cancer identified in a population-based study from Southern Brazil. PMID: 27223485 Ref: Localized Irradiation of Cell Membrane by Auger Electrons Is Cytotoxic Through Oxidative Stress-Mediated Nontargeted Effects. PMID: 27224059 Ref: Growth hormone is permissive for neoplastic colon growth. PMID: 27226307 Ref: An Association Map on the Effect of Flavonoids on the Signaling Pathways in Colorectal Cancer. PMID: 27226778 Ref: Progesterone receptor activation is required for folic acid-induced anti-proliferation in colorectal cancer cell lines. PMID: 27233474 Ref: Apoptotic effect of eugenol envolves G2/M phase abrogation accompanied by mitochondrial damage and clastogenic effect on cancer cell in vitro. PMID: 27235711 Ref: Longitudinal molecular characterization of endoscopic specimens from colorectal lesions. PMID: 27239120 Ref: Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers. PMID: 27244218 Ref: Recurrent, truncating SOX9 mutations are associated with SOX9 overexpression, KRAS mutation, and TP53 wild type status in colorectal carcinoma. PMID: 27248473 Ref: Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway. PMID: 27271587 Ref: Combination treatment with flavonoid morin and telomerase inhibitor MST312 reduces cancer stem cell traits by targeting STAT3 and telomerase. PMID: 27279256 Ref: Tanshinone I induces human colorectal cancer cell apoptosis: The potential roles of Aurora A-p53 and survivin-mediated signaling pathways. PMID: 27279458 Ref: Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer. PMID: 27283986 Ref: Cytotoxicity of seven naturally occurring phenolic compounds towards multi-factorial drug-resistant cancer cells. PMID: 27288921 Ref: Boletus edulis ribonucleic acid - a potent apoptosis inducer in human colon adenocarcinoma cells. PMID: 27302173 Ref: A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC. PMID: 27302369 Ref: Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer. PMID: 27304964 Ref: A novel TP53 pathway influences the HGS-mediated exosome formation in colorectal cancer. PMID: 27312428 Ref: P53 Is Involved in a Three-Dimensional Architecture-Mediated Decrease in Chemosensitivity in Colon Cancer. PMID: 27313779 Ref: Autophagy regulation and its role in gastric cancer and colorectal cancer. PMID: 27314289 Ref: Torilis japonica extract-generated intracellular ROS induces apoptosis by reducing the mitochondrial membrane potential via regulation of the AMPK-p38 MAPK signaling pathway in HCT116 colon cancer. PMID: 27314881 Ref: Aqueous Oldenlandia diffusa extracts inhibits colorectal cancer cells via activating AMP-activated protein kinase signalings. PMID: 27322552 Ref: Molecular pathological classification of colorectal cancer. PMID: 27325016 Ref: Combined treatment with vitamin C and sulindac synergistically induces p53- and ROS-dependent apoptosis in human colon cancer cells. PMID: 27339904 Ref: DNA Damage Is a Potential Marker for TP53 Mutation in Colorectal Carcinogenesis. PMID: 27342962 Ref: Undefined familial colorectal cancer and the role of pleiotropism in cancer susceptibility genes. PMID: 27356891 Ref: Paradoxical Reductions in Serum Anti-p53 Autoantibody Levels by Chemotherapy in Unresectable Colorectal Cancer: An Observational Study. PMID: 27362767 Ref: Knockdown delta-5-desaturase promotes the formation of a novel free radical byproduct from COX-catalyzed omega-6 peroxidation to induce apoptosis and sensitize pancreatic cancer cells to chemotherapy drugs. PMID: 27368132 Ref: Human Blood Autoantibodies in the Detection of Colorectal Cancer. PMID: 27383396 Ref: 5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-beta-synthase in colon cancer cells lacking p53. PMID: 27385096 Ref: Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer. PMID: 27385211 Ref: DNA methylation based biomarkers in colorectal cancer: A systematic review. PMID: 27385266 Ref: Prognostic significance of survivin in rectal cancer patients treated with surgery and postoperative concurrent chemo-radiation therapy. PMID: 27391438 Ref: Enhanced colon cancer chemoprevention of curcumin by nanoencapsulation with whey protein. PMID: 27404761 Ref: beta-Catenin activation in fundic gland polyps, gastric cancer and colonic polyps in families afflicted by 'gastric adenocarcinoma and proximal polyposis of the stomach' (GAPPS). PMID: 27406052 Ref: Methylsulfonylmethane Induces p53 Independent Apoptosis in HCT-116 Colon Cancer Cells. PMID: 27428957 Ref: BH3 mimetic ABT-737 sensitizes colorectal cancer cells to ixazomib through MCL-1 downregulation and autophagy inhibition. PMID: 27429848 Ref: Prognostic value of pigment epithelium-derived factor for neoadjuvant radiation therapy in patients with locally advanced rectal carcinoma. PMID: 27431441 Ref: [Mechanism of colon cancer cell apoptosis induced by telocinobufagin: role of oxidative stress and apoptosis pathway]. PMID: 27435769 Ref: Pleomorphic Carcinoma of the Colon: Morphological and Immunohistochemical Findings. PMID: 27462191 Ref: Lentivirus-mediated shRNA interference of ghrelin receptor blocks proliferation in the colorectal cancer cells. PMID: 27464938 Ref: Clinical Value of Serum p53 Antibody in the Diagnosis and Prognosis of Colorectal Cancer. PMID: 27466527 Ref: Inactivation of the FoxO3a transcription factor is associated with the production of reactive oxygen species during protein kinase CK2 downregulation-mediated senescence in human colon cancer and breast cancer cells. PMID: 27470586 Ref: Correction: MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer. PMID: 27480870 Ref: Cytotoxicity of methanol extracts of 10 Cameroonian medicinal plants towards multi-factorial drug-resistant cancer cell lines. PMID: 27484842 Ref: Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax. PMID: 27496966 Ref: Deficiency of 53BP1 inhibits the radiosensitivity of colorectal cancer. PMID: 27499037 Ref: A Ribonuclease Isolated from Wild Ganoderma Lucidum Suppressed Autophagy and Triggered Apoptosis in Colorectal Cancer Cells. PMID: 27504094 Ref: Molecular differences in the microsatellite stable phenotype between left-sided and right-sided colorectal cancer. PMID: 27509333 Ref: Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation. PMID: 27512955 Ref: Inhibition of glucosylceramide synthase eliminates the oncogenic function of p53 R273H mutant in the epithelial-mesenchymal transition and induced pluripotency of colon cancer cells. PMID: 27517620 Ref: p53 functional deficiency in human colon cancer cells promotes fibroblast-mediated angiogenesis and tumor growth. PMID: 27520561 Ref: Post-transcriptional regulation of the tumor suppressor p53 by a novel miR-27a, with implications during hypoxia and tumorigenesis. PMID: 27531966 Ref: RBBP6: a potential biomarker of apoptosis induction in human cervical cancer cell lines. PMID: 27536134 Ref: Tumor Protein (TP)-p53 Members as Regulators of Autophagy in Tumor Cells upon Marine Drug Exposure. PMID: 27537898 Ref: Apple Polyphenol Phloretin Inhibits Colorectal Cancer Cell Growth via Inhibition of the Type 2 Glucose Transporter and Activation of p53-Mediated Signaling. PMID: 27538679 Ref: Human pregnane X receptor compromises the function of p53 and promotes malignant transformation. PMID: 27547448 Ref: Two subtypes of colorectal tumor with distinct molecular features in familial adenomatous polyposis. PMID: 27563825 Ref: Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways. PMID: 27564258 Ref: Interplay Between Transcription Factors and MicroRNAs Regulating Epithelial-Mesenchymal Transitions in Colorectal Cancer. PMID: 27573895 Ref: MicroRNAs as Therapeutic Targets and Colorectal Cancer Therapeutics. PMID: 27573904 Ref: Expression Profile of p53 and p21 in Large Bowel Mucosa as Biomarkers of Inflammatory-Related Carcinogenesis in Ulcerative Colitis. 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PMID: 27629291 Ref: Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition. PMID: 27634879 Ref: p53-dependent and -independent mechanisms are involved in (E)-1-(2-hydroxyphenyl)-3-(2-methoxynaphthalen-1-yl)prop-2-en-1-one (HMP)-induced apoptosis in HCT116 colon cancer cells. PMID: 27641669 Ref: Serine/arginine-rich splicing factor 7 regulates p21-dependent growth arrest in colon cancer cells. PMID: 27644562 Ref: Decreased expression of p73 in colorectal cancer. PMID: 27654017 Ref: X-radiation enhances the collagen type I strap formation and migration potentials of colon cancer cells. PMID: 27655687 Ref: Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors. PMID: 27671336 Ref: Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseases. PMID: 27672289 Ref: Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research. PMID: 27708166 Ref: Prevalence of the CHEK2 R95* germline mutation. PMID: 27708748 Ref: Increased gene expression noise in human cancers is correlated with low p53 and immune activities as well as late stage cancer. PMID: 27713130 Ref: BAY61-3606 potentiates the anti-tumor effects of TRAIL against colon cancer through up-regulating DR4 and down-regulating NF-kappaB. PMID: 27721019 Ref: Stereoisomers of Astaxanthin Inhibit Human Colon Cancer Cell Growth by Inducing G2/M Cell Cycle Arrest and Apoptosis. PMID: 27726394 Ref: Genomic profiling of stage II and III colon cancers reveals APC mutations to be associated with survival in stage III colon cancer patients. PMID: 27729614 Ref: Cytotoxicity of methanol extracts of Annona muricata, Passiflora edulis and nine other Cameroonian medicinal plants towards multi-factorial drug-resistant cancer cell lines. PMID: 27730025 Ref: p53 increase mitochondrial copy number via up-regulation of mitochondrial transcription factor A in colorectal cancer. PMID: 27732955 Ref: High expression of fibronectin is associated with poor prognosis, cell proliferation and malignancy via the NF-kappaB/p53-apoptosis signaling pathway in colorectal cancer. PMID: 27748871 Ref: Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis. PMID: 27748879 Ref: Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing. PMID: 27756406 Ref: Anti-FIRs (PUF60) auto-antibodies are detected in the sera of early-stage colon cancer patients. PMID: 27756887 Ref: [Clinical Significance of Serum p53 Antibody Measurement in Colorectal Cancer Patients]. PMID: 27760967 Ref: microRNA-146a inhibits proliferation, migration and invasion of human cervical and colorectal cancer cells. PMID: 27769860 Ref: Subcellular protein expression models for microsatellite instability in colorectal adenocarcinoma tissue images. PMID: 27770786 Ref: [Overexpression of aplysia Ras homolog I (ARHI) increases apoptosis in colon cancer SW480 cells]. PMID: 27774944 Ref: 5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers. PMID: 27777774 Ref: miR-300 promotes proliferation and EMT-mediated colorectal cancer migration and invasion by targeting p53. PMID: 27779716 Ref: Targeted ultra-deep sequencing unveils a lack of driver-gene mutations linking non-hereditary gastrointestinal stromal tumors and highly prevalent second primary malignancies: random or nonrandom, that is the question. PMID: 27806309 Ref: PRIMA-1Met suppresses colorectal cancer independent of p53 by targeting MEK. PMID: 27806324 Ref: ING4 suppresses tumor angiogenesis and functions as a prognostic marker in human colorectal cancer. PMID: 27806345 Ref: Evaluation of a furochromone from the halophyte Corydalis heterocarpa for cytotoxic activity against human gastric cancer (AGS) cells. PMID: 27808331 Ref: TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression. PMID: 27818144 Ref: Biomarker-Based Scoring System for Prediction of Tumor Response After Preoperative Chemoradiotherapy in Rectal Cancer by Reverse Transcriptase Polymerase Chain Reaction Analysis. PMID: 27824703 Ref: Expression pattern of BCCIP in hepatocellular carcinoma is correlated with poor prognosis and enhanced cell proliferation. PMID: 27832471 Ref: Enhancement of 5-FU sensitivity by the proapoptotic rpL3 gene in p53 null colon cancer cells through combined polymer nanoparticles. PMID: 27835895 Ref: Didox and resveratrol sensitize colorectal cancer cells to doxorubicin via activating apoptosis and ameliorating P-glycoprotein activity. PMID: 27841296 Ref: Hypoxic resistance of KRAS mutant tumor cells to 3-Bromopyruvate is counteracted by Prima-1 and reversed by N-acetylcysteine. PMID: 27863474 Ref: [Expression of CD10 in tumor-associated fibroblast of cancerized or recurrent colorectal adenomas]. PMID: 27868405 Ref: Investigating cytokinesis failure as a strategy in cancer therapy. PMID: 27895316 Ref: Functional exploration of colorectal cancer genomes using Drosophila. PMID: 27897178 Ref: Newcastle disease virus degrades HIF-1alpha through proteasomal pathways independent of VHL and p53. PMID: 27902314 Ref: TP53 Polymorphisms and Colorectal Cancer Risk in Patients with Lynch Syndrome in Taiwan: A Retrospective Cohort Study. PMID: 27907203 Ref: [Inhibitory effect of jianpi-jiedu prescription-contained serum on colorectal cancer SW48 cell proliferation by mTOR-P53-P21 signalling pathway]. PMID: 27932756 Ref: Prognostic value of p53 for colorectal cancer after surgical resection of pulmonary metastases. PMID: 28003030 Ref: Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53. PMID: 28008906 Ref: Personalized oncogenomics in the management of gastrointestinal carcinomas-early experiences from a pilot study. PMID: 28050146 Ref: Sorbus rufopilosa Extract Exhibits Antioxidant and Anticancer Activities by Inducing Cell Cycle Arrest and Apoptosis in Human Colon Adenocarcinoma HT29 Cells. PMID: 28053959 Ref: The Evaluation of p53 Polymorphism at Codon 72 and Association With Breast Cancer in Iran: A Systematic Review and Meta-analysis. PMID: 28053964 Ref: [Expression of CD10 in cancer-associated fibroblasts and its effect on initiation and progression of colorectal carcinoma]. PMID: 28056302 Ref: Molecular spectrum of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC somatic gene mutations in Arab patients with colorectal cancer: determination of frequency and distribution pattern. PMID: 28078112 Ref: Combining fisetin and ionizing radiation suppresses the growth of mammalian colorectal cancers in xenograft tumor models. PMID: 28105204 Ref: Identification of potential therapeutic targets for colorectal cancer by bioinformatics analysis. PMID: 28105216 Ref: Toward Liquid Biopsy: Determination of the Humoral Immune Response in Cancer Patients Using HaloTag Fusion Protein-Modified Electrochemical Bioplatforms. PMID: 28193070 Ref: Correlation of p53 Overexpression with the Clinicopathological Prognostic Factors in Colorectal Adenocarcinoma. PMID: 28208862 Ref: Anticancer metallohelices: nanomolar potency and high selectivity. PMID: 28808525 Ref: Somatic mutation detection using various targeted detection assays in paired samples of circulating tumor DNA, primary tumor and metastases from patients undergoing resection of colorectal liver metastases. PMID: 28949453 Ref: Immunohistochemical expression of proinflammatory enzyme COX-2 and p53 in ulcerative colitis and its associated dysplasia and colorectal carcinoma. PMID: 30023227 |
Ref: Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma. PMID: 26475632 Ref: Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression. PMID: 26824338 Ref: Paired Primary and Metastatic Tumor Analysis of Somatic Mutations in Synchronous and Metachronous Colorectal Cancer. PMID: 27384156 Ref: FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation. PMID: 27399335 Ref: Subclonal diversity arises early even in small colorectal tumours and contributes to differential growth fates. PMID: 27609830 Ref: The long noncoding RNA-ROR promotes the resistance of radiotherapy for human colorectal cancer cells by targeting the p53/miR-145 pathway. PMID: 27696511 Ref: Validation of Recently Proposed Colorectal Cancer Susceptibility Gene Variants in an Analysis of Families and Patients-a Systematic Review. PMID: 27713038 Ref: Colorectal carcinomas with submucosal invasion (pT1): analysis of histopathological and molecular factors predicting lymph node metastasis. PMID: 27713420 Ref: Histone Demethylase Gene PHF2 Is Mutated in Gastric and Colorectal Cancers. PMID: 27744626 Ref: Novel mouse model recapitulates genome and transcriptome alterations in human colorectal carcinomas. PMID: 27750367 Ref: Prognostic Value of Pre- and Postoperative Anti-p53 Antibody Levels in Colorectal Cancer Patients: A Retrospective Study. PMID: 27794579 Ref: New dibutyltin(IV) ladders: Syntheses, structures and, optimization and evaluation of cytotoxic potential employing A375 (melanoma) and HCT116 (colon carcinoma) cell lines in vitro. PMID: 27815980 Ref: Class I histone deacetylases regulate p53/NF-kappaB crosstalk in cancer cells. PMID: 27838375 Ref: Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells. PMID: 27878243 Ref: Restoration of the tumor-suppressor function to mutant p53 by Ganoderma lucidum polysaccharides in colorectal cancer cells. PMID: 27878254 Ref: Evolutionary biologic changes of gut microbiota in an 'adenoma-carcinoma sequence' mouse colorectal cancer model induced by 1, 2-Dimethylhydrazine. PMID: 27880935 Ref: Hierarchical investigating the predictive value of p53, COX2, EGFR, nm23 in the post-operative patients with colorectal carcinoma. PMID: 27888614 Ref: The association between the TP53 Arg72Pro polymorphism and colorectal cancer: An updated meta-analysis based on 32 studies. PMID: 27901479 Ref: Nuclear Export of Ubiquitinated Proteins Determines the Sensitivity of Colorectal Cancer to Proteasome Inhibitor. PMID: 27903750 Ref: Is Metformin a Therapeutic Paradigm for Colorectal Cancer: Insight into the Molecular Pathway? PMID: 27919208 Ref: pathTiMEx: Joint Inference of Mutually Exclusive Cancer Pathways and Their Progression Dynamics. PMID: 27936934 Ref: ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1. PMID: 27965283 Ref: Exosomal microRNA concentrations in colorectal cancer: A mathematical model. PMID: 27993628 Ref: Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer. PMID: 28002797 Ref: Copy number variations in DCC/18q and ERBB2/17q are associated with disease-free survival in microsatellite stable colon cancer. PMID: 28006840 Ref: Clinical relevance of colorectal cancer molecular subtypes. PMID: 28010901 Ref: Curcumin inhibits growth potential by G1 cell cycle arrest and induces apoptosis in p53-mutated COLO 320DM human colon adenocarcinoma cells. PMID: 28011386 Ref: EGFR Gene Amplification and KRAS Mutation Predict Response to Combination Targeted Therapy in Metastatic Colorectal Cancer. PMID: 28025786 Ref: 5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells. PMID: 28028695 Ref: Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. PMID: 28035355 Ref: Novel derivative of aminobenzenesulfonamide (3c) induces apoptosis in colorectal cancer cells through ROS generation and inhibits cell migration. PMID: 28049506 Ref: HIPK2-T566 autophosphorylation diversely contributes to UV- and doxorubicin-induced HIPK2 activation. PMID: 28060750 Ref: The utility of tumor marker combination, including serum P53 antibody, in colorectal cancer treatment. PMID: 28062920 Ref: KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage. PMID: 28073943 Ref: KRAS and TP53 mutations in inflammatory bowel disease-associated colorectal cancer: a meta-analysis. PMID: 28077799 Ref: Molecular subtypes of colorectal cancers determined by PCR-based analysis. PMID: 28083970 Ref: The depletion of ATM inhibits colon cancer proliferation and migration via B56gamma2-mediated Chk1/p53/CD44 cascades. PMID: 28093285 Ref: Loss of CUL4A expression is underlying cisplatin hypersensitivity in colorectal carcinoma cells with acquired trabectedin resistance. PMID: 28095394 Ref: Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii. PMID: 28096658 Ref: Carboxamide analog ITR-284 evokes apoptosis and inhibits migration ability in human lung adenocarcinoma A549 cells. PMID: 28098885 Ref: Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells. PMID: 28103302 Ref: Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer. PMID: 28106826 Ref: Combined Parthenolide and Balsalazide Have Enhanced Antitumor Efficacy Through Blockade of NF-kappaB Activation. PMID: 28108625 Ref: Calreticulin is a fine tuning molecule in epibrassinolide-induced apoptosis through activating endoplasmic reticulum stress in colon cancer cells. PMID: 28112451 Ref: Growth-Inhibiting Activity of Resveratrol Imine Analogs on Tumor Cells In Vitro. PMID: 28114318 Ref: DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer. PMID: 28120820 Ref: Combined detection of the expression of Nm23-H1 and p53 is correlated with survival rates of patients with stage II and III colorectal cancer. PMID: 28123532 Ref: CQ synergistically sensitizes human colorectal cancer cells to SN-38/CPT-11 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk. PMID: 28131902 Ref: Identification of terpenoids from Rubus corchorifolius L. f. leaves and their anti-proliferative effects on human cancer cells. PMID: 28134947 Ref: Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer. PMID: 28135145 Ref: Somatic mutations in cancer: Stochastic versus predictable. PMID: 28137366 Ref: Multiregion ultra-deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer. PMID: 28145097 Ref: Variable Levels of Long Noncoding RNA Expression in DNA Mismatch Repair-Proficient Early-Stage Colon Cancer. PMID: 28160106 Ref: Novel ent-Kaurane Diterpenoid from Rubus corchorifolius L. f. Inhibits Human Colon Cancer Cell Growth via Inducing Cell Cycle Arrest and Apoptosis. PMID: 28169543 Ref: Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells (HT-29) by activating various signaling pathways. PMID: 28169560 Ref: Whole-exome sequencing identified mutational profiles of high-grade colon adenomas. PMID: 28179590 Ref: Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathway. PMID: 28182012 Ref: ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib. PMID: 28182994 Ref: Chromosome 20q Amplification Defines a Subtype of Microsatellite Stable, Left-Sided Colon Cancers with Wild-type RAS/RAF and Better Overall Survival. PMID: 28184012 Ref: Diverse repetitive element RNA expression defines epigenetic and immunologic features of colon cancer. PMID: 28194445 Ref: Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells. PMID: 28196676 Ref: The p53 isoform delta133p53ss regulates cancer cell apoptosis in a RhoB-dependent manner. PMID: 28212429 Ref: USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth. PMID: 28216017 Ref: Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors. PMID: 28218467 Ref: Discovery of Mieap-regulated mitochondrial quality control as a new function of tumor suppressor p53. PMID: 28222492 Ref: Prevalence and coexistence of KRAS, BRAF, PIK3CA, NRAS, TP53, and APC mutations in Indian colorectal cancer patients: Next-generation sequencing-based cohort study. PMID: 28222664 Ref: The in vitro and vivo effects of nuclear and cytosolic parafibromin expression on the aggressive phenotypes of colorectal cancer cells: a search of potential gene therapy target. PMID: 28223542 Ref: Antitumorigenic effect of atmospheric-pressure dielectric barrier discharge on human colorectal cancer cells via regulation of Sp1 transcription factor. PMID: 28225083 Ref: Oridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cells. PMID: 28230866 Ref: Conventional colon adenomas harbor various disturbances in microsatellite stability and contain micro-serrated foci with microsatellite instability. PMID: 28234922 Ref: CRIF1 enhances p53 activity via the chromatin remodeler SNF5 in the HCT116 colon cancer cell lines. PMID: 28235567 Ref: Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1). PMID: 28236663 Ref: Construction of a multiplex mutation hot spot PCR panel: the first step towards colorectal cancer genotyping on the GS Junior platform. PMID: 28243320 Ref: Preparation of carotenoid extracts and nanoemulsions from Lycium barbarum L. and their effects on growth of HT-29 colon cancer cells. PMID: 28266352 Ref: Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids. PMID: 28270604 Ref: Exosomes are released by bystander cells exposed to radiation-induced biophoton signals: Reconciling the mechanisms mediating the bystander effect. PMID: 28278290 Ref: The oncogenic effects of p53-inducible gene 3 (PIG3) in colon cancer cells. PMID: 28280421 Ref: Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis. PMID: 28280620 Ref: Reactivating p53 and Inducing Tumor Apoptosis (RITA) Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin. PMID: 28284059 Ref: Mus81 knockdown sensitizes colon cancer cells to chemotherapeutic drugs by activating CHK1 pathway. PMID: 28291626 Ref: AZD1775 induces toxicity through double-stranded DNA breaks independently of chemotherapeutic agents in p53-mutated colorectal cancer cells. PMID: 28296564 Ref: CD95 ligand induces senescence in mismatch repair-deficient human colon cancer via chronic caspase-mediated induction of DNA damage. PMID: 28300842 Ref: Anti-Cancerous Potential of Polysaccharide Fractions Extracted from Peony Seed Dreg on Various Human Cancer Cell Lines Via Cell Cycle Arrest and Apoptosis. PMID: 28316571 Ref: Immunohistochemical Markers as Predictors of Histopathologic Response and Prognosis in Rectal Cancer Treated with Preoperative Adjuvant Therapy: State of the Art. PMID: 28326100 Ref: TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours. PMID: 28327152 Ref: Predicted vitamin D status and colon cancer recurrence and mortality in CALGB 89803 (Alliance). PMID: 28327908 Ref: p53-inducible long non-coding RNA PICART1 mediates cancer cell proliferation and migration. PMID: 28339031 Ref: p53/microRNA-374b/AKT1 regulates colorectal cancer cell apoptosis in response to DNA damage. PMID: 28339062 Ref: Polo-like kinase 1 expression is suppressed by CCAAT/enhancer-binding protein alpha to mediate colon carcinoma cell differentiation and apoptosis. PMID: 28341486 Ref: Mitochondrial DNA alteration in primary and metastatic colorectal cancer: Different frequency and association with selected clinicopathological and molecular markers. PMID: 28345467 Ref: The DEAD-box RNA helicase DDX41 is a novel repressor of p21(WAF1/CIP1) mRNA translation. PMID: 28348086 Ref: Gambogic acid potentiates the chemosensitivity of colorectal cancer cells to 5-fluorouracil by inhibiting proliferation and inducing apoptosis. PMID: 28352348 Ref: Assessment of Olea europaea L. fruit extracts: Phytochemical characterization and anticancer pathway investigation. PMID: 28360012 Ref: miR-34a and miR-34b/c Suppress Intestinal Tumorigenesis. PMID: 28363996 Ref: Tracking a CAD-ALK gene rearrangement in urine and blood of a colorectal cancer patient treated with an ALK inhibitor. PMID: 28368455 Ref: Detection of Free Cancer Cells in Pelvic Lavage with Double Immunocytochemistry at Rectal Cancer Surgery. PMID: 28373415 Ref: Low Variability and Stable Frequency of Common Haplotypes of the TP53 Gene Region in Colorectal Cancer Patients in a Slovak Population. PMID: 28373458 Ref: RSK activation via ERK modulates human colon cancer cells response to PTHrP. PMID: 28385776 Ref: Establishment of apoptotic regulatory network for genetic markers of colorectal cancer. PMID: 28386169 Ref: Establishment of apoptotic regulatory network for genetic markers of colorectal cancer and optimal selection of traditional Chinese medicine target. PMID: 28386190 Ref: Celecoxib enhances the radiosensitivity of HCT116 cells in a COX-2 independent manner by up-regulating BCCIP. PMID: 28386336 Ref: MsrB3 deficiency induces cancer cell apoptosis through p53-independent and ER stress-dependent pathways. PMID: 28389299 Ref: p53 target miR-29c-3p suppresses colon cancer cell invasion and migration through inhibition of PHLDB2. PMID: 28392396 Ref: The suppressing effects of BTG3 expression on aggressive behaviors and phenotypes of colorectal cancer: An in vitro and vivo study. PMID: 28407690 Ref: Cytosolic calcium mediates RIP1/RIP3 complex-dependent necroptosis through JNK activation and mitochondrial ROS production in human colon cancer cells. PMID: 28414098 Ref: Is there a prognostic value of tumor location among Chinese patients with colorectal cancer? PMID: 28418874 Ref: Impact of Acetazolamide, a Carbonic Anhydrase Inhibitor, on the Development of Intestinal Polyps in Min Mice. PMID: 28420165 Ref: Dependence of p53-deficient cells on the DHX9 DExH-box helicase. PMID: 28427210 Ref: Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells. PMID: 28435028 Ref: Morphological Features and Prognostic Significance of ARID1A-Deficient Esophageal Adenocarcinomas. PMID: 28440661 Ref: Specific up-regulation of p21 by a small active RNA sequence suppresses human colorectal cancer growth. PMID: 28445988 Ref: Neural precursor cell expressed, developmentally downregulated 8activating enzyme inhibitor MLN4924 sensitizes colorectal cancer cells to oxaliplatin by inducing DNA damage, G2 cell cycle arrest and apoptosis. PMID: 28447739 Ref: Expression and clinicopathologic significance of TUFM and p53 for the normal-adenoma-carcinoma sequence in colorectal epithelia. PMID: 28449687 Ref: Apoptosis-induced effects of extract from Artemisia annua Linne by modulating PTEN/p53/PDK1/Akt/ signal pathways through PTEN/p53-independent manner in HCT116 colon cancer cells. PMID: 28454566 Ref: Inhibition of Colon Carcinoma Cell Migration Following Treatment with Purified Venom from Lesser Weever Fish (Trachinus Vipera). PMID: 28456793 Ref: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. PMID: 28459449 Ref: A rare case of choroid plexus carcinoma that led to the diagnosis of Lynch syndrome (hereditary nonpolyposis colorectal cancer). PMID: 28460341 Ref: A novel oncolytic adenovirus based on simian adenovirus serotype 24. PMID: 28460470 Ref: Cisatracurium-induced proliferation impairment and death of colorectal cancer cells, HCT116 is mediated by p53 dependent intrinsic apoptotic pathway in vitro. PMID: 28463795 Ref: The prognostic value of p53 positive in colorectal cancer: A retrospective cohort study. PMID: 28468582 Ref: [Application of PLA Method for Detection of p53/p63/p73 Complexes in Situ in Tumour Cells and Tumour Tissue]. PMID: 28471195 Ref: Local recurrences at the anastomotic area are clonally related to the primary tumor in sporadic colorectal carcinoma. PMID: 28476018 Ref: Influence of chronic low-dose/dose-rate high-LET irradiation from radium-226 in a human colorectal carcinoma cell line. PMID: 28477580 Ref: Intestinal differentiated mucinous adenocarcinoma of the endometrium with sporadic MSI high status: a case report. PMID: 28494767 Ref: Mammea longifolia Planch. and Triana Fruit Extract Induces Cell Death in the Human Colon Cancer Cell Line, SW480, via Mitochondria-Related Apoptosis and Activation of p53. PMID: 28504908 Ref: Identification of XAF1-MT2A mutual antagonism as a molecular switch in cell-fate decisions under stressful conditions. PMID: 28507149 Ref: Association between mutations of critical pathway genes and survival outcomes according to the tumor location in colorectal cancer. PMID: 28513830 Ref: Low-Dose Paclitaxel Inhibits Tumor Cell Growth by Regulating Glutaminolysis in Colorectal Carcinoma Cells. PMID: 28522974 Ref: Statin use, candidate mevalonate pathway biomarkers, and colon cancer survival in a population-based cohort study. PMID: 28524155 Ref: Targeted sequencing-based analyses of candidate gene variants in ulcerative colitis-associated colorectal neoplasia. PMID: 28524162 Ref: Lymphogenous metastasis to the transverse colon that originated from signet-ring cell gastric cancer: A case report and review of the literature. PMID: 28526245 Ref: A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53. PMID: 28526414 Ref: AKT is indispensable for coordinating Par-4/JNK cross talk in p21 downmodulation during ER stress. PMID: 28530706 Ref: Gender-related prognostic value and genomic pattern of intra-tumor heterogeneity in colorectal cancer. PMID: 28531253 Ref: The interaction between cytosine methylation and processes of DNA replication and repair shape the mutational landscape of cancer genomes. PMID: 28531315 Ref: PAK4 regulates G6PD activity by p53 degradation involving colon cancer cell growth. PMID: 28542136 Ref: Infrequently expressed miRNAs in colorectal cancer tissue and tumor molecular phenotype. PMID: 28548123 Ref: A Specific Mutational Signature Associated with DNA 8-Oxoguanine Persistence in MUTYH-defective Colorectal Cancer. PMID: 28551381 Ref: Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells. PMID: 28555064 Ref: Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer. PMID: 28561063 Ref: Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line. PMID: 28571588 Ref: Teng-Long-Bu-Zhong-Tang induces p21-dependent cell senescence in colorectal carcinoma LS174T cells via histone acetylation. PMID: 28572741 Ref: Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3. PMID: 28580901 Ref: Expression of the EP300, TP53 and BAX genes in colorectal cancer: Correlations with clinicopathological parameters and survival. PMID: 28586030 Ref: Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10. PMID: 28587923 Ref: Role of AXL in invasion and drug resistance of colon and breast cancer cells and its association with p53 alterations. PMID: 28596680 Ref: AA-NAT, MT1 and MT2 Correlates with Cancer Stem-Like Cell Markers in Colorectal Cancer: Study of the Influence of Stage and p53 Status of Tumors. PMID: 28604612 Ref: Implication of PHF2 Expression in Clear Cell Renal Cell Carcinoma. PMID: 28607325 Ref: Differences in p53 status significantly influence the cellular response and cell survival to 1,25-dihydroxyvitamin D3-metformin cotreatment in colorectal cancer cells. PMID: 28618116 Ref: Analysis of mutant allele fractions in driver genes in colorectal cancer - biological and clinical insights. PMID: 28618197 Ref: p53 Expression as a Diagnostic Biomarker in Ulcerative Colitis-Associated Cancer. PMID: 28621756 Ref: Gold-loaded nanoporous iron oxide nanocubes: a novel dispersible capture agent for tumor-associated autoantibody analysis in serum. PMID: 28627551 Ref: Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation. PMID: 28628120 Ref: Bilateral blockade of MEK- and PI3K-mediated pathways downstream of mutant KRAS as a treatment approach for peritoneal mucinous malignancies. PMID: 28640835 Ref: Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity. PMID: 28655792 Ref: P53-induced miR-30e-5p inhibits colorectal cancer invasion and metastasis by targeting ITGA6 and ITGB1. PMID: 28656629 Ref: Levistolide A Induces Apoptosis via ROS-Mediated ER Stress Pathway in Colon Cancer Cells. PMID: 28662507 Ref: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. PMID: 28675510 Ref: Heterogeneity in the colorectal primary tumor and the synchronous resected liver metastases prior to and after treatment with an anti-EGFR monoclonal antibody. PMID: 28685087 Ref: Regulation of tubular recycling endosome biogenesis by the p53-MICALL1 pathway. PMID: 28714518 Ref: Anticarcinogenic Effects of Dried Citrus Peel in Colon Carcinogenesis Due to Inhibition of Oxidative Stress. PMID: 28718722 Ref: Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-kappaB Signaling. PMID: 28726723 Ref: Morphology with immunohistochemical and genetic profiling of high-grade neuroendocrine carcinoma of colon - a case report with review of literature. PMID: 28730258 Ref: BMP7 mediates the anticancer effect of honokiol by upregulating p53 in HCT116 cells. PMID: 28731124 Ref: miR-141 Inhibits Proliferation and Migration of Colorectal Cancer SW480 Cells. PMID: 28739727 Ref: Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity. PMID: 28745318 Ref: Effects of PKM2 Gene Silencing on the Proliferation and Apoptosis of Colorectal Cancer LS-147T and SW620 Cells. PMID: 28746922 Ref: SMG-1 kinase attenuates mitochondrial ROS production but not cell respiration deficits during hyperoxia. PMID: 28749708 Ref: Cellular expression, in-vitro and in-vivo confirmation of GAEC1 oncogenic properties in colon cancer. PMID: 28764863 Ref: Molecular Characterization of Somatic Alterations in Dukes' B and C Colorectal Cancers by Targeted Sequencing. PMID: 28769798 Ref: An innovative immunosensor for detection of tumor suppressor protein p53 in unprocessed human plasma and cancer cell lysates. PMID: 28774804 Ref: Wip1 gene silencing enhances the chemosensitivity of human colon cancer cells. PMID: 28781635 Ref: Synergistic activity and heterogeneous acquired resistance of combined MDM2 and MEK inhibition in KRAS mutant cancers. PMID: 28783173 Ref: p53 performs an essential role in mediating the oncogenic stimulus triggered by loss of expression of neurofibromatosis type 2 during in vitro tumor progression. PMID: 28789444 Ref: Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites. PMID: 28790461 Ref: Identification of the anticancer effects of a novel proteasome inhibitor, ixazomib, on colorectal cancer using a combined method of microarray and bioinformatics analysis. PMID: 28790851 Ref: Aberrantly methylated-differentially expressed genes and pathways in colorectal cancer. PMID: 28794688 Ref: Gender-related prognostic significance of clinical and biological tumor features in rectal cancer patients receiving short-course preoperative radiotherapy. PMID: 28794690 Ref: Biphasic ROS production, p53 and BIK dictate the mode of cell death in response to DNA damage in colon cancer cells. PMID: 28796811 Ref: Differences of protein expression profiles, KRAS and BRAF mutation, and prognosis in right-sided colon, left-sided colon and rectal cancer. PMID: 28801584 Ref: A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PMID: 28806777 Ref: Mesua ferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells, through modulation of multiple cell signalling pathways. PMID: 28807224 Ref: TP53 Mutational Status and ROS Effect the Expression of the Survivin-Associated Radio-Adaptive Response. PMID: 28813624 Ref: The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. PMID: 28813679 Ref: Synergistic antitumor effect of 3-bromopyruvate and 5-fluorouracil against human colorectal cancer through cell cycle arrest and induction of apoptosis. PMID: 28816773 Ref: Anticancer Activity of Ramalin, a Secondary Metabolite from the Antarctic Lichen Ramalina terebrata, against Colorectal Cancer Cells. PMID: 28817102 Ref: LRF inhibits p53 expression in colon cancer cells via modulating DAP5 activity. PMID: 28849590 Ref: Clinical significance of serum anti-p53 antibody expression following curative surgery for colorectal cancer. PMID: 28855992 Ref: Phosphoproteomic Analysis Identifies Signaling Pathways Regulated by Curcumin in Human Colon Cancer Cells. PMID: 28870897 Ref: In vitro and in vivo inhibitory effects of a Pleurotus eryngii protein on colon cancer cells. PMID: 28880032 Ref: NFATc3 mediates the sensitivity of gastric cancer cells to arsenic sulfide. PMID: 28881766 Ref: [The value of serum human tumor protein P53 in colorectal cancer combined diagnosis and postoperative monitoring]. PMID: 28910954 Ref: Rhus coriaria increases protein ubiquitination, proteasomal degradation and triggers non-canonical Beclin-1-independent autophagy and apoptotic cell death in colon cancer cells. PMID: 28912474 Ref: Metformin Has Positive Therapeutic Effects in Colon Cancer and Lung Cancer. PMID: 28918830 Ref: In vitro anticancer activity of new gold(III) porphyrin complexes in colon cancer cells. PMID: 28923355 Ref: Protein expression of Fragile Histidine Triad and cyclooxgenase-2 in serrated neoplasia of the colorectum. PMID: 28927131 Ref: Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression. PMID: 28928376 Ref: Identification of novel methylated targets in colorectal cancer by microarray analysis and construction of co-expression network. PMID: 28928808 Ref: Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer. PMID: 28939741 Ref: Synthesis, structure-activity relationships and preliminary mechanism of action of novel water-soluble 4-quinolone-3-carboxamides as antiproliferative agents. PMID: 28942112 Ref: Long non-coding RNA HNF1A-AS1 mediated repression of miR-34a/SIRT1/p53 feedback loop promotes the metastatic progression of colon cancer by functioning as a competing endogenous RNA. PMID: 28943452 Ref: Sulforaphane induces p53deficient SW480 cell apoptosis via the ROSMAPK signaling pathway. PMID: 28944886 Ref: Expression of ERCC1, RRM1, TUBB3 in correlation with apoptosis repressor ARC, DNA mismatch repair proteins and p53 in liver metastasis of colorectal cancer. PMID: 28949378 Ref: Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells. PMID: 28981110 Ref: Wild-type and mutant p53 differentially modulate miR-124/iASPP feedback following pohotodynamic therapy in human colon cancer cell line. PMID: 29022915 Ref: In vitro effects of Apixaban on 5 different cancer cell lines. PMID: 29023465 Ref: Molecular profiling of colorectal pulmonary metastases and primary tumours: implications for targeted treatment. PMID: 29029407 Ref: Colorectal carcinoma with osseous metaplasia. PMID: 29029440 Ref: Pien Tze Huang inhibits the proliferation of colorectal cancer cells by increasing the expression of miR-34c-5p. PMID: 29042999 Ref: Increased Frequency of KRAS Mutations in African Americans Compared with Caucasians in Sporadic Colorectal Cancer. PMID: 29048416 Ref: Inhibitory effect of hyperoside isolated from Zanthoxylum bungeanum leaves on SW620 human colorectal cancer cells via induction of the p53 signaling pathway and apoptosis. PMID: 29067453 Ref: CDK1 interacts with iASPP to regulate colorectal cancer cell proliferation through p53 pathway. PMID: 29069733 Ref: Acquired somatic TP53 or PIK3CA mutations are potential predictors of when polyps evolve into colorectal cancer. PMID: 29069792 Ref: p53 expression in patients with ulcerative colitis - associated with dysplasia and carcinoma: a systematic meta-analysis. PMID: 29070013 Ref: Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines. PMID: 29078261 Ref: KO of 5-InsP7 kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype. PMID: 29078269 Ref: Partially Purified Gloriosa superba Peptides Inhibit Colon Cancer Cell Viability by Inducing Apoptosis Through p53 Upregulation. PMID: 29078848 Ref: [Effect of resveratrol in regulating proliferation and apoptosis of rectal cancer cells via up-regulating PTEN]. PMID: 29082697 Ref: Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features. PMID: 29085228 Ref: Establishing a colorectal cancer liver metastasis patient-derived tumor xenograft model for the evaluation of personalized chemotherapy. PMID: 29094026 Ref: Functional consequence of the p53 codon 72 polymorphism in colorectal cancer. PMID: 29100333 Ref: Critical Role of p53 and K-ras in the Diagnosis of Early Colorectal Cancer: a One-year, Single-center Analysis. PMID: 29104470 Ref: Pteisolic acid G, a novel ent-kaurane diterpenoid, inhibits viability and induces apoptosis in human colorectal carcinoma cells. PMID: 29113182 Ref: Grape seed proanthocyanidins induce mitochondrial pathway-mediated apoptosis in human colorectal carcinoma cells. PMID: 29113217 Ref: JAB1-STAT3 activation loop is associated with recurrence following 5-fluorouracil-based adjuvant chemotherapy in human colorectal cancer. PMID: 29113268 Ref: Exploring conserved mRNA-miRNA interactions in colon and lung cancers. PMID: 29118934 Ref: RRS1 silencing suppresses colorectal cancer cell proliferation and tumorigenesis by inhibiting G2/M progression and angiogenesis. PMID: 29137316 Ref: Beta-catenin and p53 expression in topographic compartments of colorectal cancer and its prognostic value following surgery. PMID: 29146051 Ref: Metformin transiently inhibits colorectal cancer cell proliferation as a result of either AMPK activation or increased ROS production. PMID: 29167573 Ref: Development and validation of a panel of five proteins as blood biomarkers for early detection of colorectal cancer. PMID: 29184444 Ref: MiR-215-5p is a tumor suppressor in colorectal cancer targeting EGFR ligand epiregulin and its transcriptional inducer HOXB9. PMID: 29199273 Ref: Anticancer effect of dentatin and dentatin-hydroxypropyl-beta-cyclodextrin complex on human colon cancer (HT-29) cell line. PMID: 29200826 Ref: Apoptosis induction of colorectal cancer cells HTL-9 in vitro by the transformed products of soybean isoflavones by Ganoderma lucidum. PMID: 29204990 Ref: Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer: critical role of p53. PMID: 29212503 Ref: Hsp90 inhibitor sensitizes TRAIL-mediated apoptosis via chop-dependent DR5 upregulation in colon cancer cells. PMID: 29218092 Ref: The MiR-495/Annexin A3/P53 Axis Inhibits the Invasion and EMT of Colorectal Cancer Cells. PMID: 29224019 Ref: Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway. PMID: 29254217 Ref: Cytotoxic, antioxidative, genotoxic and antigenotoxic effects of Horchata, beverage of South Ecuador. PMID: 29258490 Ref: Loss of p53-inducible long non-coding RNA LINC01021 increases chemosensitivity. PMID: 29262524 Ref: High RNA-Binding Motif Protein 3 (RBM3) Expression is Independently Associated with Prolonged Overall Survival in Intestinal-Type Gastric Cancer. PMID: 29263314 Ref: Study of the role of telomerase in colorectal cancer: preliminary report and literature review. PMID: 29280699 Ref: Hyperthermia exposure induces apoptosis and inhibits proliferation in HCT116 cells by upregulating miR-34a and causing transcriptional activation of p53. PMID: 29285066 Ref: TP53 Gene Pro72Arg (rs1042522) Single Nucleotide Polymorphism as Not a Risk Factor for Colorectal Cancer in the Iranian Azari Population PMID: 29286614 Ref: Cytotoxic Profiling of Plant Secondary Metabolites on P53 Variant Human Colon Carcinoma Cell Lines. PMID: 29308058 Ref: p21 does, but p53 does not predict pathological response to preoperative chemoradiotherapy in locally advanced rectal cancer. PMID: 29332339 Ref: LRP6 targeting suppresses gastric tumorigenesis via P14(ARF)-Mdm2-P53-dependent cellular senescence. PMID: 29340077 Ref: Analysis of 12 variants in the development of gastric and colorectal cancers. PMID: 29358861 Ref: Xylopine Induces Oxidative Stress and Causes G2/M Phase Arrest, Triggering Caspase-Mediated Apoptosis by p53-Independent Pathway in HCT116 Cells. PMID: 29362667 Ref: Cyclin-dependent kinase 2 inhibitor SU9516 increases sensitivity of colorectal carcinoma cells Caco-2 but not HT29 to BH3 mimetic ABT-737. PMID: 29372687 Ref: Network analysis of common genes related to esophageal, gastric, and colon cancers. PMID: 29379595 Ref: Common and differential genetically pathways between ulcerative colitis and colon adenocarcinoma. PMID: 29511478 Ref: Establishment of optimal regulatory network of colorectal cancer based on p42.3 protein. PMID: 29551923 Ref: How does inflammation drive mutagenesis in colorectal cancer? PMID: 30147278 |
Ref: Metabolic response evaluation for colorectal liver metastases and correlation to pathologic response and tumour markers. PMID: 27452367 Ref: Molecular Predictors of Response to Neoadjuvant Chemoradiation for Rectal Cancer. PMID: 27740975 Ref: HDAC inhibitors show differential epigenetic regulation and cell survival strategies on p53 mutant colon cancer cells. PMID: 28264628 Ref: CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells. PMID: 28389531 Ref: Scorpion Venom Causes Upregulation of p53 and Downregulation of Bcl-xL and BID Protein Expression by Modulating Signaling Proteins Erk(1/2) and STAT3, and DNA Damage in Breast and Colorectal Cancer Cell Lines. PMID: 28438053 Ref: CB002, a novel p53 tumor suppressor pathway-restoring small molecule induces tumor cell death through the pro-apoptotic protein NOXA. PMID: 28749203 Ref: Frameshift Mutations in Repeat Sequences of ANK3, HACD4, TCP10L, TP53BP1, MFN1, LCMT2, RNMT, TRMT6, METTL8 and METTL16 Genes in Colon Cancers. PMID: 28803425 Ref: Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway. PMID: 28822989 Ref: RCC2 is a novel p53 target in suppressing metastasis. PMID: 28869598 Ref: Clinicopathologic and Molecular Characteristics of Synchronous Colorectal Carcinoma With Mismatch Repair Deficiency. PMID: 28877066 Ref: Expression of ATF6 as a marker of pre-cancerous atypical change in ulcerative colitis-associated colorectal cancer: a potential role in the management of dysplasia. PMID: 28884228 Ref: Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis. PMID: 28937686 Ref: Triggering p53 activation is essential in ziyuglycoside I-induced human retinoblastoma WERI-Rb-1 cell apoptosis. PMID: 28960612 Ref: Berbamine suppresses cell viability and induces apoptosis in colorectal cancer via activating p53-dependent apoptotic signaling pathway. PMID: 28965196 Ref: The small molecule AU14022 promotes colorectal cancer cell death via p53-mediated G2/M-phase arrest and mitochondria-mediated apoptosis. PMID: 29030986 Ref: Genome-wide association study identified copy number variants associated with sporadic colorectal cancer risk. PMID: 29079706 Ref: Expression of KLF6-SV2 in colorectal cancer and its impact on proliferation and apoptosis. PMID: 29084019 Ref: Ultrasensitive electrochemical immunosensing of tumor suppressor protein p53 in unprocessed human plasma and cell lysates using a novel nanocomposite based on poly-cysteine/graphene quantum dots/gold nanoparticle. PMID: 29113888 Ref: Simvastatin enhances the radiosensitivity of p53deficient cells via inhibition of mouse double minute 2 homolog. PMID: 29115437 Ref: Molecular Profiling of Patients With Advanced Colorectal Cancer: Princess Margaret Cancer Centre Experience. PMID: 29128266 Ref: Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient-derived spheroid cultures. PMID: 29130628 Ref: Germline Genetic Features of Young Individuals With Colorectal Cancer. PMID: 29146522 Ref: MicroRNAs as novel biomarkers for colorectal cancer: New outlooks. PMID: 29156521 Ref: Identification of genes involved in the four stages of colorectal cancer: Gene expression profiling. PMID: 29179987 Ref: Classifying Colorectal Cancer by Tumor Location Rather than Sidedness Highlights a Continuum in Mutation Profiles and Consensus Molecular Subtypes. PMID: 29180604 Ref: The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival. PMID: 29187402 Ref: APTM, a Thiophene Heterocyclic Compound, Inhibits Human Colon Cancer HCT116 Cell Proliferation Through p53-Dependent Induction of Apoptosis. PMID: 29215922 Ref: Radiotherapy-Activated Cancer-Associated Fibroblasts Promote Tumor Progression through Paracrine IGF1R Activation. PMID: 29217764 Ref: TAp73 inhibits cell invasion and migration by directly activating KAI1 expression in colorectal carcinoma. PMID: 29222041 Ref: Molecular profiling and genome-wide analysis based on somatic copy number alterations in advanced colorectal cancers. PMID: 29230882 Ref: Prediagnostic Antibodies to Serum p53 and Subsequent Colorectal Cancer. PMID: 29254936 Ref: Wee1 inhibition can suppress tumor proliferation and sensitize p53 mutant colonic cancer cells to the anticancer effect of irinotecan. PMID: 29257266 Ref: Induction of apoptosis by pyrazolo[3,4-d]pyridazine derivative in lung cancer cells via disruption of Bcl-2/Bax expression balance. PMID: 29290491 Ref: Mutations of key driver genes in colorectal cancer progression and metastasis. PMID: 29322354 Ref: Integrative omics analysis of p53-dependent regulation of metabolism. PMID: 29323703 Ref: Appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid are genetically distinct from primary colorectal-type adenocarcinoma of the appendix. PMID: 29327707 Ref: Temozolomide analog PMX 465 downregulates MGMT expression in HCT116 colorectal carcinoma cells. PMID: 29331023 Ref: Apoptosis induction by Pleurotus sajor-caju (Fr.) Singer extracts on colorectal cancer cell lines. PMID: 29337231 Ref: Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers. PMID: 29343849 Ref: Insight into the role of PIKK family members and NF-small ka, CyrillicB in DNAdamage-induced senescence and senescence-associated secretory phenotype of colon cancer cells. PMID: 29352261 Ref: NF-kappaB-induced WIP1 expression promotes colorectal cancer cell proliferation through mTOR signaling. PMID: 29367109 Ref: Autophagic flux is essential for the downregulation of D-dopachrome tautomerase by atractylenolide I to ameliorate intestinal adenoma formation. PMID: 29368299 Ref: DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a. PMID: 29394130 Ref: Peloruside A-Induced Cell Death in Hypoxia Is p53 Dependent in HCT116 Colorectal Cancer Cells. PMID: 29400463 Ref: Phosphatidylinositol 3-Kinase alpha-Selective Inhibition With Alpelisib (BYL719) in PIK3CA-Altered Solid Tumors: Results From the First-in-Human Study. PMID: 29401002 Ref: Mechanism of action of the atypical retinoid ST1926 in colorectal cancer: DNA damage and DNA polymerase alpha. PMID: 29416919 Ref: Implication of KRT16, FAM129A and HKDC1 genes as ATF4 regulated components of the integrated stress response. PMID: 29420561 Ref: Topographic, histological and molecular study of aberrant crypt foci identified in human colon in different clinical groups. PMID: 29422806 Ref: Three molecular pathways model colorectal carcinogenesis in Lynch syndrome. PMID: 29424427 Ref: A disposable immunosensor using ITO based electrode modified by a star-shaped polymer for analysis of tumor suppressor protein p53 in human serum. PMID: 29425857 Ref: Silencing Artemis Enhances Colorectal Cancer Cell Sensitivity to DNA-damaging Agents. PMID: 29426373 Ref: ZFP36L1 and ZFP36L2 inhibit cell proliferation in a cyclin D-dependent and p53-independent manner. PMID: 29426877 Ref: PIK3CA and TP53 mutations predict overall survival of stage II/III colorectal cancer patients. PMID: 29434452 Ref: Deciphering the biochemical and molecular mechanism underlying the in vitro and in vivo chemotherapeutic efficacy of ruthenium quercetin complex in colon cancer. PMID: 29442390 Ref: Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterations. PMID: 29453410 Ref: Nondysplastic Ulcerative Colitis Has High Levels of the Homologous Recombination Repair Protein NUCKS1 and Low Levels of the DNA Damage Marker Gamma-H2AX. PMID: 29462394 Ref: Src is the primary target of aripiprazole, an atypical antipsychotic drug, in its anti-tumor action. PMID: 29464048 Ref: A novel purified Lactobacillus acidophilus 20079 exopolysaccharide, LA-EPS-20079, molecularly regulates both apoptotic and NF-kappaB inflammatory pathways in human colon cancer. PMID: 29466981 Ref: Selenium-Enriched Saccharomyces cerevisiae Reduces the Progression of Colorectal Cancer. PMID: 29468612 Ref: Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246. PMID: 29472616 Ref: Cullin-1 and -2 Protein Expression in Colorectal Cancer: Correlation with Clinicopathological Variables. PMID: 29475926 Ref: Inhibition of autophagy enhances DENSpm-induced apoptosis in human colon cancer cells in a p53 independent manner. PMID: 29492901 Ref: Riluzole Inhibits Proliferation, Migration and Cell Cycle Progression and Induces Apoptosis in Tumor Cells of Various Origins. PMID: 29493465 Ref: [Relationships between the enrichment of ETBF, Fn, Hp in intestinal and colorectal cancer]. PMID: 29502368 Ref: The Immunome of Colon Cancer: Functional In Silico Analysis of Antigenic Proteins Deduced from IgG Microarray Profiling. PMID: 29505855 Ref: Long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) promote cell proliferation in colorectal cancer by affecting P53. PMID: 29509245 Ref: Arylamine N-acetyltransferase 1 protects against reactive oxygen species during glucose starvation: Role in the regulation of p53 stability. PMID: 29518119 Ref: APC:T1556fs and STK11 mutations in duodenal adenomas and adenocarcinomas. PMID: 29525853 Ref: Multifactorial Modes of Action of Arsenic Trioxide in Cancer Cells as Analyzed by Classical and Network Pharmacology. PMID: 29535630 Ref: Monitoring colorectal cancer following surgery using plasma circulating tumor DNA. PMID: 29541205 Ref: Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-alpha, and HMGB1. PMID: 29546074 Ref: Pramlintide, an antidiabetic, is antineoplastic in colorectal cancer and synergizes with conventional chemotherapy. PMID: 29551915 Ref: Potential diagnostic value of serum p53 antibody for detecting colorectal cancer: A meta-analysis. PMID: 29556296 Ref: Extracted metabolite from Streptomyces Levis ABRIINW111 altered the gene expression in colon cancer. PMID: 29564063 Ref: POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim. PMID: 29573636 Ref: Deciphering the molecular mechanism and apoptosis underlying the in-vitro and in-vivo chemotherapeutic efficacy of vanadium luteolin complex in colon cancer. PMID: 29574863 Ref: Validation of the systematic scoring of immunohistochemically stained tumour tissue microarrays using QuPath digital image analysis. PMID: 29575153 Ref: Mutation analysis of adenomas and carcinomas of the colon: Early and late drivers. PMID: 29575536 Ref: Mitochondrial dysfunction suppresses p53 expression via calcium-mediated nuclear factor-kB signaling in HCT116 human colorectal carcinoma cells. PMID: 29580374 Ref: TP53 mutations and number of alterations correlate with maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) [(18)F] fluorodeoxyglucose ((18)F-FDG PET). PMID: 29581845 Ref: Butyrate, a dietary fiber derivative that improves irinotecan effect in colon cancer cells. PMID: 29587241 Ref: Racial Disparities in the Molecular Landscape of Cancer. PMID: 29599344 Ref: Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response. PMID: 29604063 Ref: The Biological Effect and Clinical Application of Long Noncoding RNAs in Colorectal Cancer. PMID: 29614491 Ref: Prognostic significance of CD117 expression and TP53 missense mutations in triple-negative breast cancer. PMID: 29616097 Ref: A Network Pharmacology Approach to Uncover the Multiple Mechanisms of Hedyotis diffusa Willd. on Colorectal Cancer. PMID: 29619072 Ref: Omega-3 fatty acid DHA modulates p53, survivin, and microRNA-16-1 expression in KRAS-mutant colorectal cancer stem-like cells. PMID: 29619114 Ref: Alterations in the p53-SOCS2 axis contribute to tumor growth in colon cancer. PMID: 29622769 Ref: PMN inhibits colorectal cancer cells through inducing mitotic arrest and p53-dependent apoptosis via the inhibition of tubulin polymerization. PMID: 29626471 Ref: Revisiting colorectal cancer animal model - An improved metastatic model for distal rectosigmoid colon carcinoma. PMID: 29628185 Ref: The apoptotic effects of Brucea javanica fruit extract against HT29 cells associated with p53 upregulation and inhibition of NF-kappaB translocation. PMID: 29636600 Ref: The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 1: the suppression of cell proliferation, promotion of apoptosis and arrest of the cell cycle. PMID: 29645049 Ref: The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer. PMID: 29651325 Ref: TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma. PMID: 29653964 Ref: Phenylbutyl isoselenocyanate induces reactive oxygen species to inhibit androgen receptor and to initiate p53-mediated apoptosis in LNCaP prostate cancer cells. PMID: 29668110 Ref: Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation. PMID: 29669932 Ref: The Marine Dinoflagellate Alexandrium andersoni Induces Cell Death in Lung and Colorectal Tumor Cell Lines. PMID: 29679250 Ref: Multi-panel assay of serum autoantibodies in colorectal cancer. PMID: 29691673 Ref: Population-based statistical inference for temporal sequence of somatic mutations in cancer genomes. PMID: 29697365 Ref: Performance validation of an amplicon-based targeted next-generation sequencing assay and mutation profiling of 648 Chinese colorectal cancer patients. PMID: 29705968 Ref: Molecular Landscape of ERBB2/ERBB3 Mutated Colorectal Cancer. PMID: 29718453 Ref: Histogram analysis of ADC in rectal cancer: associations with different histopathological findings including expression of EGFR, Hif1-alpha, VEGF, p53, PD1, and KI 67. A preliminary study. PMID: 29719621 Ref: Identification of specific and common diagnostic antibody markers for gastrointestinal cancers by SEREX screening using testis cDNA phage library. PMID: 29719626 Ref: The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis. PMID: 29721061 Ref: The family of apoptosis-stimulating proteins of p53 is dysregulated in colorectal cancer patients. PMID: 29731851 Ref: miR-211 regulates the expression of RRM2 in tumoral metastasis and recurrence in colorectal cancer patients with a k-ras gene mutation. PMID: 29731918 Ref: Dihydroartemisinin potentiates antitumor activity of 5-fluorouracil against a resistant colorectal cancer cell line. PMID: 29738772 Ref: Resveratrol analogue, (E)-N-(2-(4-methoxystyryl) phenyl) furan-2-carboxamide induces G2/M cell cycle arrest through the activation of p53-p21(CIP1/WAF1) in human colorectal HCT116 cells. PMID: 29754265 Ref: Hotspot KRAS exon 2 mutations in CD166 positive colorectal cancer and colorectal adenoma cells. PMID: 29755662 Ref: Increased mucosal expression of miR-215 precedes the development of neoplasia in patients with long-standing ulcerative colitis. PMID: 29755683 Ref: Wasabi 6-(methylsulfinyl)hexyl isothiocyanate induces apoptosis in human colorectal cancer cells through p53-independent mitochondrial dysfunction pathway. PMID: 29756671 Ref: Molecular Background of Colorectal Tumors From Patients With Lynch Syndrome Associated With Germline Variants in PMS2. PMID: 29758216 Ref: The role of heme iron molecules derived from red and processed meat in the pathogenesis of colorectal carcinoma. PMID: 29759553 Ref: PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids. PMID: 29760071 Ref: Spindle Assembly Disruption and Cancer Cell Apoptosis with a CLTC-Binding Compound. PMID: 29769406 Ref: DNA content analysis of colorectal serrated lesions detects an aneuploid subset of inflammatory bowel disease-associated serrated epithelial change and traditional serrated adenomas. PMID: 29772067 Ref: Varacin-1, a novel analog of varacin C, induces p53-independent apoptosis in cancer cells through ROS-mediated reduction of XIAP. PMID: 29773887 Ref: G9a stimulates CRC growth by inducing p53 Lys373 dimethylation-dependent activation of Plk1. PMID: 29774081 Ref: 1,2,3,4,6-Penta-O-galloyl-beta-d-glucose suppresses colon cancer through induction of tumor suppressor. PMID: 29778287 Ref: Integrated analysis of colorectal cancer microRNA datasets: identification of microRNAs associated with tumor development. PMID: 29779016 Ref: The anti-cancer activity of an andrographolide analogue functions through a GSK-3beta-independent Wnt/beta-catenin signaling pathway in colorectal cancer cells. PMID: 29784906 Ref: Mapping the HLA Ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation. PMID: 29789417 Ref: Massively parallel sequencing analysis of mucinous ovarian carcinomas: genomic profiling and differential diagnoses. PMID: 29793804 Ref: Comprehensive molecular analysis based on somatic copy number alterations in intramucosal colorectal neoplasias and early invasive colorectal cancers. PMID: 29796160 Ref: Copper-redox cycling by coumarin-di(2-picolyl)amine hybrid molecule leads to ROS-mediated DNA damage and apoptosis: A mechanism for cancer chemoprevention. PMID: 29803612 Ref: Upregulation of let-7f-5p promotes chemotherapeutic resistance in colorectal cancer by directly repressing several pro-apoptotic proteins. PMID: 29805607 Ref: Activation of the p53 pathway with digiferrol isolated from Rubia philippinensis induces cell cycle arrest, apoptosis, and autophagy in colon cancer cells. PMID: 29842910 Ref: B-cell lymphoma 2 is associated with advanced tumor grade and clinical stage, and reduced overall survival in young Chinese patients with colorectal carcinoma. PMID: 29844818 Ref: Identification of different mutational profiles in cancers arising in specific colon segments by next generation sequencing. PMID: 29844865 Ref: Combined assessment of the TNM stage and BRAF mutational status at diagnosis in sporadic colorectal cancer patients. PMID: 29844874 Ref: Angiodrastic Chemokines in Colorectal Cancer: Clinicopathological Correlations. PMID: 29850390 Ref: Phase II study of panitumumab combined with capecitabine and oxaliplatin as first-line treatment in metastatic colorectal cancer patients: clinical results including extended tumor genotyping. PMID: 29855806 Ref: The p53-signaling pathway and colorectal cancer: Interactions between downstream p53 target genes and miRNAs. PMID: 29860032 Ref: Quinalizarin Induces Apoptosis through Reactive Oxygen Species (ROS)-Mediated Mitogen-Activated Protein Kinase (MAPK) and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathways in Colorectal Cancer Cells. PMID: 29860266 Ref: Ruthenium-Containing Linear Helicates and Mesocates with Tuneable p53-Selective Cytotoxicity in Colorectal Cancer Cells. PMID: 29863754 Ref: L-carnosine induces apoptosis/cell cycle arrest via suppression of NF-kappaB/STAT1 pathway in HCT116 colorectal cancer cells. PMID: 29869056 Ref: Yin Yang 1 promotes the Warburg effect and tumorigenesis via glucose transporter GLUT3. PMID: 29869834 Ref: Association of mRNA expression of TP53 and the TP53 codon 72 Arg/Pro gene polymorphism with colorectal cancer risk in Asian population: a bioinformatics analysis and meta-analysis. PMID: 29872345 Ref: Cyclophilin B induces chemoresistance by degrading wild-type p53 via interaction with MDM2 in colorectal cancer. PMID: 29876924 Ref: Pea lectin inhibits cell growth by inducing apoptosis in SW480 and SW48 cell lines. PMID: 29885391 Ref: Novel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2-STAT3 pathway. PMID: 29892198 Ref: LACTB, a novel epigenetic silenced tumor suppressor, inhibits colorectal cancer progression by attenuating MDM2-mediated p53 ubiquitination and degradation. PMID: 29899406 Ref: A452, an HDAC6-selective inhibitor, synergistically enhances the anticancer activity of chemotherapeutic agents in colorectal cancer cells. PMID: 29917295 Ref: Acriflavine enhances the antitumor activity of the chemotherapeutic drug 5-fluorouracil in colorectal cancer cells. PMID: 29928378 Ref: p53 positively regulates the expression of cancer stem cell marker CD133 in HCT116 colon cancer cells. PMID: 29928431 Ref: Clinical significance and prognostic relevance of KRAS, BRAF, PI3K and TP53 genetic mutation analysis for resectable and unresectable colorectal liver metastases: A systematic review of the current evidence. PMID: 29937183 Ref: Gene promoter and exon DNA methylation changes in colon cancer development - mRNA expression and tumor mutation alterations. PMID: 29945573 Ref: Clonal Structures of Regionally Synchronous Gastric Adenomas and Carcinomas. PMID: 29945994 Ref: Sensitization of colorectal cancer cells to irinotecan by the Survivin inhibitor LLP3 depends on XAF1 proficiency in the context of mutated p53. PMID: 29947891 Ref: Metabolic Imaging Phenotype Using Radiomics of [(18)F]FDG PET/CT Associated with Genetic Alterations of Colorectal Cancer. PMID: 29948642 Ref: Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4. PMID: 29954944 Ref: Liver kinase B1/adenosine monophosphate-activated protein kinase signaling axis induces p21/WAF1 expression in a p53-dependent manner. PMID: 29963200 Ref: Survivin antagonizes chemotherapy-induced cell death of colorectal cancer cells. PMID: 29963241 Ref: The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1. PMID: 29966255 Ref: Dynamics of Genome Alterations in Crohn's Disease-Associated Colorectal Carcinogenesis. PMID: 29967250 Ref: ANIMAL MODELS FOR COLORECTAL CANCER. PMID: 29972397 Ref: Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancer. PMID: 29975776 Ref: Differences in gene mutations according to gender among patients with colorectal cancer. PMID: 29976257 Ref: MicroRNA molecular profiling identifies potential signaling pathways conferring resistance to chemoradiation in locally-advanced rectal adenocarcinoma. PMID: 29988972 Ref: Aneuploidy of chromosome 8 and mutation of circulating tumor cells predict pathologic complete response in the treatment of locally advanced rectal cancer. PMID: 30008877 Ref: Genome doubling shapes the evolution and prognosis of advanced cancers. PMID: 30013179 Ref: Knockdown of metadherin inhibits cell proliferation and migration in colorectal cancer. PMID: 30015962 Ref: Mechanistic Insight into Size-Dependent Enhanced Cytotoxicity of Industrial Antibacterial Titanium Oxide Nanoparticles on Colon Cells Because of Reactive Oxygen Species Quenching and Neutral Lipid Alteration. PMID: 30023799 Ref: Genomic alterations accompanying tumour evolution in colorectal cancer: tracking the differences between primary tumours and synchronous liver metastases by whole-exome sequencing. PMID: 30029640 Ref: Regulation of tNOX expression through the ROS-p53-POU3F2 axis contributes to cellular responses against oxaliplatin in human colon cancer cells. PMID: 30029680 Ref: A Novel Inhibitor Targets Both Wnt Signaling and ATM/p53 in Colorectal Cancer. PMID: 30032112 Ref: Deep sequencing and pathway-focused analysis revealed multigene oncodriver signatures predicting survival outcomes in advanced colorectal cancer. PMID: 30032163 Ref: LonP1 Differently Modulates Mitochondrial Function and Bioenergetics of Primary Versus Metastatic Colon Cancer Cells. PMID: 30038898 Ref: A genome-wide analysis of colorectal cancer in a child with Noonan syndrome. PMID: 30039904 Ref: Targeting the MDM2-p53 protein-protein interaction with prenylchalcones: Synthesis of a small library and evaluation of potential antitumor activity. PMID: 30041135 Ref: Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series. PMID: 30042065 Ref: Oncogenic heterogeneous nuclear ribonucleoprotein D-like promotes the growth of human colon cancer SW620 cells via its regulation of cell-cycle. PMID: 30052712 Ref: Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability. PMID: 30056083 Ref: Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy. PMID: 30059758 Ref: Label-free distinction between p53+/+ and p53 -/- colon cancer cells using a graphene based SERS platform. PMID: 30059864 Ref: Manzamine A Exerts Anticancer Activity against Human Colorectal Cancer Cells. PMID: 30060617 Ref: MicroRNA-552 links Wnt signaling to p53 tumor suppressor in colorectal cancer. PMID: 30066856 Ref: Establishment of three novel cell lines derived from African American patients with colorectal carcinoma: A unique tool for assessing racial health disparity. PMID: 30066857 Ref: Cinnamtannin B-1 inhibits cell survival molecules and induces apoptosis in colon cancer. PMID: 30066888 Ref: Cytotoxic Potential and Molecular Pathway Analysis of Silver Nanoparticles in Human Colon Cancer Cells HCT116. PMID: 30072642 Ref: RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation. PMID: 30076409 Ref: Improving anticancer activity towards colon cancer cells with a new p53-activating agent. PMID: 30076608 Ref: Myocardin-related transcription factor A (MRTF-A) mediates doxorubicin-induced PERP transcription in colon cancer cells. PMID: 30078679 Ref: Ascorbic Acid Chemosensitizes Colorectal Cancer Cells and Synergistically Inhibits Tumor Growth. PMID: 30083105 Ref: Radiosensitization by irinotecan is attributed to G2/M phase arrest, followed by enhanced apoptosis, probably through the ATM/Chk/Cdc25C/Cdc2 pathway in p53-mutant colorectal cancer cells. PMID: 30085332 Ref: Icariin reduces human colon carcinoma cell growth and metastasis by enhancing p53 activities. PMID: 30088538 Ref: Metachronous rectal metastasis from primary transverse colon cancer: a case report. PMID: 30094696 Ref: Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice via Increasing Levels of IL6R and PAI1. PMID: 30099074 Ref: Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells. PMID: 30103008 Ref: Synthesis of 2,6-Diamino-Substituted Purine Derivatives and Evaluation of Cell Cycle Arrest in Breast and Colorectal Cancer Cells. PMID: 30103421 Ref: Evaluation of potential anti-cancer activity of cationic liposomal nanoformulated Lycopodium clavatum in colon cancer cells. PMID: 30104445 Ref: Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion. PMID: 30107178 Ref: Cisatracurium Retards Cell Migration and Invasion Upon Upregulation of p53 and Inhibits the Aggressiveness of Colorectal Cancer. PMID: 30108509 Ref: Synthesis and Cytotoxicity Studies of Novel NHC*-Gold(I) Complexes Derived from Lepidiline A. PMID: 30110951 Ref: Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells. PMID: 30111797 Ref: Cytotoxic Profiling of Endogenous Metabolites Relevant to Chronic Fatigue Immune Dysfunction Syndrome (CFIDS) on p53 Variant Human Colon Carcinoma Cell Lines. PMID: 30116169 Ref: MicroRNA-423-5p inhibits colon cancer growth by promoting caspase-dependent apoptosis. PMID: 30116373 Ref: Difference Between Left-Sided and Right-Sided Colorectal Cancer: A Focused Review of Literature. PMID: 30116425 Ref: Replica to the Opinion Letter regarding the article "Sensitization of colorectal cancer cells to irinotecan by the Survivin inhibitor LLP3 depends on XAF1 proficiency in the context of mutated p53" (Arch Toxicol https://doi.org/10.1007/s00204-018-240-x). PMID: 30120489 Ref: Current insight into a cancer-implicated long noncoding RNA ZFAS1 and correlative functional mechanisms involved. PMID: 30122315 Ref: TP53-dependence on the effect of doxorubicin and Src inhibitor combination therapy. PMID: 30124118 Ref: Medicinal supplement genipin induces p53 and Bax-dependent apoptosis in colon cancer cells. PMID: 30127884 Ref: ARHGAP24 regulates cell ability and apoptosis of colorectal cancer cells via the regulation of P53. PMID: 30127956 Ref: Anticancer effects of oridonin on colon cancer are mediated via BMP7/p38 MAPK/p53 signaling. PMID: 30132514 Ref: Mechanism of Cepharanthine Cytotoxicity in Human Ovarian Cancer Cells. PMID: 30142661 Ref: PR-LncRNA signature regulates glioma cell activity through expression of SOX factors. PMID: 30143669 Ref: Serine/threonine kinase 31 promotes PDCD5-mediated apoptosis in p53-dependent human colon cancer cells. PMID: 30144069 Ref: Elevated expression of p53 in early colon polyps in a pig model of human familial adenomatous polyposis. PMID: 30145695 Ref: MALAT1-miR663a negative feedback loop in colon cancer cell functions through direct miRNA-lncRNA binding. PMID: 30154407 Ref: EXOSC4 functions as a potential oncogene in development and progression of colorectal cancer. PMID: 30155936 Ref: Ferroptosis-inducing agents enhance TRAIL-induced apoptosis through upregulation of death receptor 5. PMID: 30160785 Ref: Role of ferroptosis in hepatocellular carcinoma. PMID: 30167889 Ref: HMGA2 promotes intestinal tumorigenesis by facilitating MDM2-mediated ubiquitination and degradation of p53. PMID: 30175854 Ref: Close interplay of nitro-oxidative stress, advanced glycation end products and inflammation in inflammatory bowel diseases. PMID: 30182837 Ref: In Vitro Study of Colon Cancer Cell Migration Using E-Jet 3D Printed Cell Culture Platforms. PMID: 30187643 Ref: Novel isothiacalothrixin B analogues exhibit cytotoxic activity on human colon cancer cells in vitro by inducing irreversible DNA damage. PMID: 30188913 Ref: Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer. PMID: 30191522 Ref: The prognostic and therapeutic values of long noncoding RNA PANDAR in colorectal cancer. PMID: 30191971 Ref: Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer. PMID: 30191976 Ref: Sorbus commixta water extract induces apoptotic cell death via a ROS-dependent pathway. PMID: 30197667 Ref: Total ginsenosides of Chinese ginseng induces cell cycle arrest and apoptosis in colorectal carcinoma HT-29 cells. PMID: 30197678 Ref: Contribution of allelic imbalance to colorectal cancer. PMID: 30202008 Ref: Assessment of intratumor immune-microenvironment in colorectal cancers with extranodal extension of nodal metastases. PMID: 30202242 Ref: Prognostic Implications of Mucinous Differentiation in Metastatic Colorectal Carcinoma Can Be Explained by Distinct Molecular and Clinicopathologic Characteristics. PMID: 30205948 Ref: The roles and mechanisms of G3BP1 in tumour promotion. PMID: 30207743 Ref: Reactive Oxygen Species and p53 Mediated Activation of p38 and Caspases is Critically Involved in Kaempferol Induced Apoptosis in Colorectal Cancer Cells. PMID: 30211553 Ref: Sequential treatment with celecoxib and bortezomib enhances the ER stress-mediated autophagy-associated cell death of colon cancer cells. PMID: 30214587 Ref: Chaetominine induces cell cycle arrest in human leukemia K562 and colon cancer SW1116 cells. PMID: 30214601 Ref: Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer. PMID: 30219719 Ref: Proliferative and Invasive Colorectal Tumors in Pet Dogs Provide Unique Insights into Human Colorectal Cancer. PMID: 30223484 Ref: RASSF1A suppresses colorectal tumor cell growth through p53-dependent p21(WAF1) activation. PMID: 30226276 Ref: Drug resistance and new therapies in colorectal cancer. PMID: 30228778 Ref: [Crohn's disease-associated colorectal carcinogenesis : TP53 mutations and copy number gains of chromosome arm 5p as (early) markers of tumor progression]. PMID: 30229283 Ref: Somatic cancer genetics in the UK: real-world data from phase I of the Cancer Research UK Stratified Medicine Programme. PMID: 30233821 Ref: A novel p.Gly187Arg TP53 variant appears to result in Li-Fraumeni syndrome. PMID: 30239254 Ref: Profiles of alternative splicing in colorectal cancer and their clinical significance: A study based on large-scale sequencing data. PMID: 30243491 Ref: Baicalein Inhibits Proliferation Activity of Human Colorectal Cancer Cells HCT116 Through Downregulation of Ezrin. PMID: 30244250 Ref: Novel genetic mutations detected by multigene panel are associated with hereditary colorectal cancer predisposition. PMID: 30256826 Ref: Differential expression of mucin 1 and mucin 2 in colorectal cancer. PMID: 30271081 Ref: Advanced Glycation End Products Increase MDM2 Expression via Transcription Factor KLF5. PMID: 30271790 Ref: Expression levels of hnRNP K and p21WAF1/CIP1 are associated with resistance to radiochemotherapy independent of p53 pathway activation in rectal adenocarcinoma. PMID: 30272263 Ref: Expression of Plasma miRNA-221 in Colorectal Carcinoma Patients and its Diagnostic Significance in Comparison with p53 Expression. PMID: 30274025 Ref: Positive effect of single nucleotide RAD51 135G>C polymorphism and low Ku70 protein expression on female rectal cancer patients survival after preoperative radiotherapy. PMID: 30289394 Ref: Possible role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in human breast cancer. PMID: 30290054 Ref: Colonic Lysine Homocysteinylation Induced by High-Fat Diet Suppresses DNA Damage Repair. PMID: 30304680 Ref: PTBP1 promotes tumorigenesis by regulating apoptosis and cell cycle in colon cancer. PMID: 30309622 Ref: Synergistic Interaction of Rutin and Silibinin on Human Colon Cancer Cell Line. PMID: 30314650 Ref: ACTH-Secreting Neuroendocrine Carcinoma of the Cecum: Case Report and Review of the Literature. PMID: 30314823 Ref: Association between p53 Arg72Pro polymorphism and colorectal cancer risk in Asian population: a meta-analysis. PMID: 30316510 Ref: PIG3 suppresses gastric cancer proliferation by regulating p53- mediated apoptosis. PMID: 30334411 Ref: A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53. PMID: 30339780 Ref: Human UTP14a promotes colorectal cancer progression by forming a positive regulation loop with c-Myc. PMID: 30343112 Ref: Effects and mechanism of STAT3 silencing on the growth and apoptosis of colorectal cancer cells. PMID: 30344711 Ref: Quantitative analysis of somatically-acquired and constitutive uniparental disomy in gastrointestinal cancers. PMID: 30350313 Ref: Novel targeting approaches and signaling pathways of colorectal cancer: An insight. PMID: 30357011 Ref: Quantitative evaluation of TP53 immunohistochemistry to predict gene mutations: lessons learnt from a series of colorectal carcinomas. PMID: 30359636 Ref: Bio-Effects of TiO2 Nanoparticles on Human Colorectal Cancer and Umbilical Vein Endothelial Cell Lines PMID: 30361551 Ref: beta-Ketoiminato iridium(III) organometallic complexes: Selective cytotoxicity towards colorectal cancer cells HCT116 p53-/. PMID: 30362193 Ref: The clinical impact of miRNA34a and P53 gene expression in colon cancer. PMID: 30377673 Ref: Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway. PMID: 30387805 |