Primary Site >> Colorectal Cancer
Gene >> TLR4
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Ref: Epidemiological factors of cancer in California. PMID: 1464811 |
Ref: Bacterial lipopolysaccharide induces transforming growth factor beta and hepatocyte growth factor through toll-like receptor 2 in cultured human colon cancer cells. PMID: 11725828 |
Ref: Cellular differentiation-induced attenuation of LPS response in HT-29 cells is related to the down-regulation of TLR4 expression. PMID: 16202385 |
Ref: The expression patterns of Toll-like receptors in the ileal pouch mucosa of postoperative ulcerative colitis patients. PMID: 16493544 Ref: Polymorphism of CD14 gene but not the mutation of TLR4 gene is associated with colorectal cancer in Chinese patients. PMID: 16706818 Ref: The burden of gastrointestinal and liver diseases, 2006. PMID: 16848807 Ref: Microsatelite GT polymorphism in the toll-like receptor 2 is associated with colorectal cancer. PMID: 16879199 Ref: Polymorphisms within inflammatory genes and colorectal cancer. PMID: 17062130 Ref: Intracellular expression of toll-like receptor 4 in neuroblastoma cells and their unresponsiveness to lipopolysaccharide. PMID: 17156435 |
Ref: Reduced expression of TLR4 is associated with the metastatic status of human colorectal cancer. PMID: 17549384 Ref: TLR4 signalling in the intestine in health and disease. PMID: 18031248 Ref: Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. PMID: 18054559 |
Ref: TLR4 signaling in cancer cells promotes chemoattraction of immature dendritic cells via autocrine CCL20. PMID: 18083111 Ref: Rapamycin suppresses TLR4-triggered IL-6 and PGE(2) production of colon cancer cells by inhibiting TLR4 expression and NF-kappaB activation. PMID: 18343502 Ref: Experiences of self-care in patients with colorectal cancer: a longitudinal study. PMID: 18764852 Ref: Rapamycin reverses TLR4 signaling-triggered tumor apoptosis resistance by disrupting Akt-mediated Bcl-xL upregulation. PMID: 18789402 Ref: CD4+CD25+ Tregs control the TRAIL-dependent cytotoxicity of tumor-infiltrating DCs in rodent models of colon cancer. PMID: 18830416 Ref: [Expression of toll-like receptor 4 in colorectal cancer]. PMID: 19106585 |
Ref: Silencing of TLR4 decreases liver tumor burden in a murine model of colorectal metastasis and hepatic steatosis. PMID: 19165543 Ref: Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors. PMID: 19229991 Ref: Practical techniques for detection of Toll-like receptor-4 in the human intestine. PMID: 19378023 Ref: Bacterial endotoxin enhances colorectal cancer cell adhesion and invasion through TLR-4 and NF-kappaB-dependent activation of the urokinase plasminogen activator system. PMID: 19436306 Ref: Toll-like receptor 4 activation increases Akt phosphorylation in colon cancer cells. PMID: 19596916 Ref: [Regulation of immune suppressive cytokines by TLR4 activation in colon cancer cells]. PMID: 19598032 Ref: Toll-like receptors and the tendency of normal mucous membrane to transform to polyp or colorectal cancer. PMID: 19609015 Ref: Lipopolysaccharide (LPS) increases the invasive ability of pancreatic cancer cells through the TLR4/MyD88 signaling pathway. PMID: 19722233 Ref: Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer. PMID: 19760027 Ref: Single nucleotide polymorphism typing of the human toll-like receptor 4 gene at the 2-kb upstream region of the 5' untranslated region: New enclosure strategy for the risk grouping of poorly-differentiated gastric adenocarcinoma patients. PMID: 21475784 |
Ref: Immunogenic death of colon cancer cells treated with oxaliplatin. PMID: 19881547 Ref: Bacillus calmette-guerin cell wall cytoskeleton enhances colon cancer radiosensitivity through autophagy. PMID: 19901560 Ref: High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer. PMID: 20145615 Ref: Actions of vitamin D are mediated by the TLR4 pathway in inflammation-induced colon cancer. PMID: 20214986 Ref: Expression and functional research of TLR4 in human colon carcinoma. PMID: 20228668 Ref: Enhancement of antitumor effect using dendritic cells activated with natural killer cells in the presence of Toll-like receptor agonist. PMID: 20386085 Ref: An apple oligogalactan prevents against inflammation and carcinogenesis by targeting LPS/TLR4/NF-kappaB pathway in a mouse model of colitis-associated colon cancer. PMID: 20400476 Ref: Persistent cyclooxygenase-2 inhibition downregulates NF-{kappa}B, resulting in chronic intestinal inflammation in the min/+ mouse model of colon tumorigenesis. PMID: 20484034 Ref: Significant association between toll-like receptor gene polymorphisms and gallbladder cancer. PMID: 20492496 Ref: TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells. PMID: 20526283 Ref: [Study on the molecular expression and regulation of toll pathway in HT-29 cells]. PMID: 20848773 Ref: In vitro screening of probiotics and synbiotics according to anti-inflammatory and anti-proliferative effects. PMID: 20951454 Ref: The tumor microenvironment of colorectal cancer: stromal TLR-4 expression as a potential prognostic marker. PMID: 21059221 |
Ref: Toll-like receptor 4 facilitates binding of Shiga toxin to colon carcinoma and primary umbilical vein endothelial cells. PMID: 21054580 Ref: Activation of PAR2 or/and TLR4 promotes SW620 cell proliferation and migration via phosphorylation of ERK1/2. PMID: 21152870 Ref: Engaging physical activity policymakers. PMID: 21350257 Ref: LPS-induced TLR4 signaling in human colorectal cancer cells increases beta1 integrin-mediated cell adhesion and liver metastasis. PMID: 21363926 Ref: Extracellular Calcium-Sensing Receptor Inhibition of Intestinal EpithelialTNF Signaling Requires CaSR-Mediated Wnt5a/Ror2 Interaction. PMID: 21603229 Ref: Variant Toll-like receptor4 (Asp299Gly and Thr399Ile alleles) and Toll-like receptor2 (Arg753Gln and Arg677Trp alleles) in colorectal cancer. PMID: 21625017 Ref: LBP and CD14 polymorphisms correlate with increased colorectal carcinoma risk in Han Chinese. PMID: 21633598 Ref: Low molecular weight hyaluronan preconditioning of tumor-pulsed dendritic cells increases their migratory ability and induces immunity against murine colorectal carcinoma. PMID: 21638126 Ref: Prebiotic treatment reduced preneoplastic lesions through the downregulation of toll like receptor 4 in a chemo-induced carcinogenic model. PMID: 21765608 Ref: Colon cancer-derived factors activate NF-kappaB in myeloid cells via TLR2 to link inflammation and tumorigenesis. PMID: 21822539 Ref: Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal cells and is associated with advanced human colon cancer. PMID: 21920464 Ref: Early lesion formation in colorectal carcinogenesis is associated with adiponectin status whereas neoplastic lesions are associated with diet and sex in C57BL/6J mice. PMID: 21958077 Ref: Alteration of CXCR7 expression mediated by TLR4 promotes tumor cell proliferation and migration in human colorectal carcinoma. PMID: 22180778 Ref: Toll-like receptor 4 signaling integrates intestinal inflammation with tumorigenesis: lessons from the murine model of colitis-associated cancer. PMID: 24212947 |
Ref: Toll-like receptor genes and their association with colon and rectal cancer development and prognosis. PMID: 21792899 Ref: Tissue expression of Toll-like receptors 2 and 4 in sporadic human colorectal cancer. PMID: 21845432 Ref: Toll-like receptors in the inflammatory response during open and laparoscopic colectomy for colorectal cancer. PMID: 21898023 Ref: Anti-inflammatory effects of resveratrol occur via inhibition of lipopolysaccharide-induced NF-kappaB activation in Caco-2 and SW480 human colon cancer cells. PMID: 22251620 Ref: Microarray Analyses of Genes Differentially Expressed by Diet (Black Beans and Soy Flour) during Azoxymethane-Induced Colon Carcinogenesis in Rats. PMID: 22496968 Ref: Cancer in inflammatory bowel disease: lessons from animal models. PMID: 22614440 Ref: Loss-of-function alleles of P2RX7 and TLR4 fail to affect the response to chemotherapy in non-small cell lung cancer. PMID: 22737602 Ref: Increased NFk-B activity in HCT116 colorectal cancer cell line harboring TLR4 Asp299Gly variant. PMID: 22761186 Ref: Expression of BMP2, TLR3, TLR4 and COX2 in colorectal polyps, adenoma and adenocarcinoma. PMID: 22923219 Ref: TLR4 signaling promotes immune escape of human colon cancer cells by inducing immunosuppressive cytokines and apoptosis resistance. PMID: 23035361 Ref: TLR-4 signalling accelerates colon cancer cell adhesion via NF-kappaB mediated transcriptional up-regulation of Nox-1. PMID: 23071493 Ref: A TLR4-interacting peptide inhibits lipopolysaccharide-stimulated inflammatory responses, migration and invasion of colon cancer SW480 cells. PMID: 23264896 |
Ref: Functional polymorphisms of Toll-like receptors 2 and 4 alter the risk for colorectal carcinoma in Europeans. PMID: 22999059 Ref: Potential association between TLR4 and chitinase 3-like 1 (CHI3L1/YKL-40) signaling on colonic epithelial cells in inflammatory bowel disease and colitis-associated cancer. PMID: 23170831 Ref: Microbiota and innate immunity in intestinal inflammation and neoplasia. PMID: 23207600 Ref: Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors. PMID: 23547558 Ref: TLR4 activates the beta-catenin pathway to cause intestinal neoplasia. PMID: 23691015 Ref: Linking inflammation to tumorigenesis in a mouse model of high-fat-diet-enhanced colon cancer. PMID: 23735174 Ref: Toll-like receptor-4 expression by stromal fibroblasts is associated with poor prognosis in colorectal cancer. PMID: 23799413 Ref: [The role of TLR4 receptor in development of inflammation and carcinogenesis in ulcerative colitis and pharmacotherapy of this disorder]. PMID: 23905422 Ref: Increased Th17-inducing activity of CD14+ CD163 low myeloid cells in intestinal lamina propria of patients with Crohn's disease. PMID: 23993972 Ref: The human TLR4 variant D299G mediates inflammation-associated cancer progression in the intestinal epithelium. PMID: 24073372 Ref: Modified apple polysaccharides suppress the migration and invasion of colorectal cancer cells induced by lipopolysaccharide. PMID: 24074742 Ref: Peripheral CD45RO, PD-1, and TLR4 expression in metastatic colorectal cancer patients treated with bevacizumab, fluorouracil, and irinotecan (FOLFIRI-B). PMID: 24114613 Ref: TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy. PMID: 24154870 Ref: 5-Fluorouracil Induce the Expression of TLR4 on HCT116 Colorectal Cancer Cell Line Expressing Different Variants of TLR4. PMID: 24250621 Ref: Combinations of TLR ligands: a promising approach in cancer immunotherapy. PMID: 24371445 Ref: beta-2 microglobulin is unsuitable as an internal reference gene for the analysis of gene expression in human colorectal cancer. PMID: 24648917 Ref: Correlation of Asp299Gly and Thr399Ile polymorphisms in toll-like receptor 4 gene with digestive cancer risk: A meta-analysis. PMID: 24648938 |
Ref: Constitutive TLR4 signalling in intestinal epithelium reduces tumor load by increasing apoptosis in APC(Min/+) mice. PMID: 23318418 Ref: Positive link between variant Toll-like receptor 4 (Asp299Gly and Thr399Ile) and colorectal cancer patients with advanced stage and lymph node metastasis. PMID: 23949880 Ref: Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway. PMID: 24232001 Ref: TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells. PMID: 24362470 Ref: Expression of toll-like receptors on human rectal adenocarcinoma cells. PMID: 24390484 Ref: Correlation between genetic polymorphisms within IL-1B and TLR4 genes and cancer risk in a Russian population: a case-control study. PMID: 24446182 Ref: MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice. PMID: 24603458 Ref: Graphene oxide triggers toll-like receptors/autophagy responses in vitro and inhibits tumor growth in vivo. PMID: 24652749 Ref: Role of toll-like receptor 4 in colorectal carcinogenesis: a meta-analysis. PMID: 24705379 Ref: Comparative analysis of innate immune system function in metastatic breast, colorectal, and prostate cancer patients with circulating tumor cells. PMID: 24731923 Ref: In silico and Ex vivo approaches identify a role for toll-like receptor 4 in colorectal cancer. PMID: 24887394 Ref: Intervention on toll-like receptors in pancreatic cancer. PMID: 24914341 Ref: A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon cancer via caspase-8. PMID: 24934366 Ref: Multiple roles of toll-like receptor 4 in colorectal cancer. PMID: 25076949 Ref: Association between Toll-like receptor 4 and interleukin 17 gene polymorphisms and colorectal cancer susceptibility in Northeast China. PMID: 25216863 Ref: Upregulation of TLRs and IL-6 as a marker in human colorectal cancer. PMID: 25547486 Ref: Toll-like receptor signaling in colorectal cancer: carcinogenesis to cancer therapy. PMID: 25548469 Ref: The TLR4/NF-kappaB signaling pathway mediates the growth of colon cancer. PMID: 25555874 |
Ref: A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4. PMID: 24469032 Ref: Apple polysaccharide reduces NF-Kb mediated colitis-associated colon carcinogenesis. PMID: 25412264 Ref: Upregulation of Toll-like receptor 2 expression in colorectal cancer infected by human cytomegalovirus. PMID: 25435993 Ref: LPS receptor subunits have antagonistic roles in epithelial apoptosis and colonic carcinogenesis. PMID: 25633197 Ref: Polymorphisms in NFKB1 and TLR4 and interaction with dietary and life style factors in relation to colorectal cancer in a Danish prospective case-cohort study. PMID: 25705893 Ref: Expression of Toll-like receptors in the mucosa of patients with ulcerative colitis. PMID: 25780451 Ref: The immune microenvironment of the colorectal tumor: Involvement of immunity genes and microRNAs belonging to the TH17 pathway. PMID: 25911397 Ref: Redox status of high-mobility group box 1 performs a dual role in angiogenesis of colorectal carcinoma. PMID: 26099505 Ref: TLR2 and TLR4 polymorphisms influence mRNA and protein expression in colorectal cancer. PMID: 26167073 Ref: Molecular Response of Human Monocytes Following Interaction with Colon Cancer Cells by Pre-treatment with Low-dose Lipopolysaccharide. PMID: 26168489 Ref: Toll-like receptor 4 gene polymorphisms and susceptibility to colorectal cancer: a meta-analysis and review. PMID: 26322080 Ref: Human Colon Tumors Express a Dominant-Negative Form of SIGIRR That Promotes Inflammation and Colitis-Associated Colon Cancer in Mice. PMID: 26344057 Ref: Negative prognostic impact of regulatory T cell infiltration in surgically resected esophageal cancer post-radiochemotherapy. PMID: 26369701 |
Ref: Perioperative treatment with the new synthetic TLR-4 agonist GLA-SE reduces cancer metastasis without adverse effects. PMID: 26453448 Ref: Adenomatous polyposis coli genotype-dependent toll-like receptor 4 activity in colon cancer. PMID: 26760960 Ref: Expression and Polymorphism of Toll-Like Receptor 4 and Effect on NF-kappaB Mediated Inflammation in Colon Cancer Patients. PMID: 26771524 Ref: CCL-34, a synthetic toll-like receptor 4 activator, modulates differentiation and maturation of myeloid dendritic cells. PMID: 26883191 Ref: Cell-surface markers for colon adenoma and adenocarcinoma. PMID: 26894861 Ref: Mesenchymal-epithelial signalling in tumour microenvironment: role of high-mobility group Box 1. PMID: 26979829 Ref: TLR4 siRNA inhibits proliferation and invasion in colorectal cancer cells by downregulating ACAT1 expression. PMID: 27177773 Ref: Impact of Pattern Recognition Receptors on the Prognosis of Breast Cancer Patients Undergoing Adjuvant Chemotherapy. PMID: 27197163 Ref: MiR-205 and MiR-373 Are Associated with Aggressive Human Mucinous Colorectal Cancer. PMID: 27271572 Ref: Quercetin Suppresses the Migration and Invasion in Human Colon Cancer Caco-2 Cells Through Regulating Toll-like Receptor 4/Nuclear Factor-kappa B Pathway. PMID: 27279714 Ref: Therapeutic effect of hydroxychloroquine on colorectal carcinogenesis in experimental murine colitis. PMID: 27288548 Ref: Eritoran Suppresses Colon Cancer by Altering a Functional Balance in Toll-like Receptors That Bind Lipopolysaccharide. PMID: 27328732 Ref: Enhanced TLR4 Expression on Colon Cancer Cells After Chemotherapy Promotes Cell Survival and Epithelial-Mesenchymal Transition Through Phosphorylation of GSK3beta. PMID: 27354597 Ref: Structural Change in Microbiota by a Probiotic Cocktail Enhances the Gut Barrier and Reduces Cancer via TLR2 Signaling in a Rat Model of Colon Cancer. PMID: 27384052 Ref: sTLR4/MD-2 complex inhibits colorectal cancer in vitro and in vivo by targeting LPS. PMID: 27409669 Ref: GSK-3beta-mediated fatty acid synthesis enhances epithelial to mesenchymal transition of TLR4-activated colorectal cancer cells through regulation of TAp63. PMID: 27599658 Ref: Extracellular HSP110 skews macrophage polarization in colorectal cancer. PMID: 27622020 Ref: Lipopolysaccharide increases the release of VEGF-C that enhances cell motility and promotes lymphangiogenesis and lymphatic metastasis through the TLR4- NF-kappaB/JNK pathways in colorectal cancer. PMID: 27713159 Ref: Sodium butyrate protects mice from the development of the early signs of non-alcoholic fatty liver disease: role of melatonin and lipid peroxidation. PMID: 27876107 Ref: NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. PMID: 27951586 Ref: Lack of Adrenomedullin Results in Microbiota Changes and Aggravates Azoxymethane and Dextran Sulfate Sodium-Induced Colitis in Mice. PMID: 27965594 Ref: CXCR4-CXCL12-CXCR7, TLR2-TLR4, and PD-1/PD-L1 in colorectal cancer liver metastases from neoadjuvant-treated patients. PMID: 28123896 |
Ref: TLR4-mediated galectin-1 production triggers epithelial-mesenchymal transition in colon cancer cells through ADAM10- and ADAM17-associated lactate production. PMID: 27837433 Ref: Casticin induced apoptotic cell death and altered associated gene expression in human colon cancer colo 205 cells. PMID: 27862857 Ref: Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-kappaB, and Up-regulating Expression of MicroRNA-21. PMID: 27876571 Ref: Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice. PMID: 28126350 Ref: Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin. PMID: 28179508 Ref: Beware! Are bacteria raising your oxidative stress? PMID: 28228598 Ref: An apple oligogalactan enhances the growth inhibitory effect of 5-fluorouracil on colorectal cancer. PMID: 28389232 Ref: Risk Stratification for Surgical Site Infections in Colon Cancer. PMID: 28403477 Ref: All-Trans Retinoic Acid Modulates TLR4/NF-kappaB Signaling Pathway Targeting TNF-alpha and Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer. PMID: 28408791 Ref: Resistin causes G1 arrest in colon cancer cells through upregulation of SOCS3. PMID: 28417458 Ref: Invasive Fusobacterium nucleatum activates beta-catenin signaling in colorectal cancer via a TLR4/P-PAK1 cascade. PMID: 28423670 Ref: Dual effect of silymarin on experimental non-alcoholic steatohepatitis induced by irinotecan. PMID: 28454924 Ref: KDM3A promotes inhibitory cytokines secretion by participating in TLR4 regulation of Foxp3 transcription in lung adenocarcinoma cells. PMID: 28521455 Ref: Pigs, Unlike Mice, Have Two Distinct Colonic Stem Cell Populations Similar to Humans That Respond to High-Calorie Diet prior to Insulin Resistance. PMID: 28576788 Ref: Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy. PMID: 28753429 Ref: Divergent expression of bacterial wall sensing Toll-like receptors 2 and 4 in colorectal cancer. PMID: 28765705 Ref: Multiple Gene-Environment Interactions on the Angiogenesis Gene-Pathway Impact Rectal Cancer Risk and Survival. PMID: 28956832 Ref: Keratin 8 reduces colonic permeability and maintains gut microbiota homeostasis, protecting against colitis and colitis-associated tumorigenesis. PMID: 29228570 |
Ref: Loss of BMI-1 dampens migration and EMT of colorectal cancer in inflammatory microenvironment through TLR4/MD-2/MyD88-mediated NF-kappaB signaling. PMID: 28815730 Ref: Blood transcriptional and microRNA responses to short-term exposure to disinfection by-products in a swimming pool. PMID: 29122314 Ref: MicroRNA-6869-5p acts as a tumor suppressor via targeting TLR4/NF-kappaB signaling pathway in colorectal cancer. PMID: 29206292 Ref: Protective effect of Coptisine from Rhizoma Coptidis on LPS/D-GalN-induced acute liver failure in mice through up-regulating expression of miR-122. PMID: 29253766 Ref: Cytosolic high-mobility group box protein 1 (HMGB1) and/or PD-1+ TILs in the tumor microenvironment may be contributing prognostic biomarkers for patients with locally advanced rectal cancer who have undergone neoadjuvant chemoradiotherapy. PMID: 29270668 Ref: Aspirin inhibited the metastasis of colon cancer cells by inhibiting the expression of toll-like receptor 4. PMID: 29308184 Ref: Prediction of novel target genes and pathways involved in bevacizumab-resistant colorectal cancer. PMID: 29342159 Ref: Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis in Mice via a Toll-Like Receptor 4/p21-Activated Kinase 1 Cascade. PMID: 29508166 Ref: Effects of Consumer Antimicrobials Benzalkonium Chloride, Benzethonium Chloride, and Chloroxylenol on Colonic Inflammation and Colitis-Associated Colon Tumorigenesis in Mice. PMID: 29514330 Ref: An Asparagus polysaccharide fraction inhibits MDSCs by inducing apoptosis through toll-like receptor 4. PMID: 29532545 Ref: Meat and fiber intake and interaction with pattern recognition receptors (TLR1, TLR2, TLR4, and TLR10) in relation to colorectal cancer in a Danish prospective, case-cohort study. PMID: 29566186 Ref: Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice. PMID: 29696632 Ref: Polymorphisms in genes related to inflammation and obesity and colorectal adenoma risk. PMID: 29802748 Ref: A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice. PMID: 29848663 Ref: Evaluation of the detection of Toll-like receptors (TLRs) in cancer development and progression in patients with colorectal cancer. PMID: 29883450 Ref: Aspirin inhibited the metastasis of colon cancer cells by inhibiting the expression of toll-like receptor 4. PMID: 29942487 Ref: Translationally controlled tumor protein affects colorectal cancer metastasis through the high mobility group box 1-dependent pathway. PMID: 30066846 Ref: Fusobacterium nucleatum promotes M2 polarization of macrophages in the microenvironment of colorectal tumours via a TLR4-dependent mechanism. PMID: 30121899 Ref: Effects of Supplemental Calcium and Vitamin D on Expression of Toll-Like Receptors and Phospho-IKKalpha/beta in the Normal Rectal Mucosa of Colorectal Adenoma Patients. PMID: 30209117 Ref: Butyrate upregulates the TLR4 expression and the phosphorylation of MAPKs and NK-kappaB in colon cancer cell in vitro. PMID: 30214578 Ref: Trapping of Lipopolysaccharide to Promote Immunotherapy against Colorectal Cancer and Attenuate Liver Metastasis. PMID: 30387230 |