Primary Site >> Colorectal Cancer
Gene >> TIMP2
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Ref: Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues. PMID: 2380196 |
Ref: Stromal expression of 72 kda type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia. PMID: 1323219 |
Ref: Expression pattern of metalloproteinases and their inhibitors changes with the progression of human sporadic colorectal neoplasia. PMID: 8269281 |
Ref: Enhanced expression of tissue inhibitors of metalloproteinases in human colorectal tumors. PMID: 8895669 |
Ref: Expression of tissue inhibitor of metalloproteinases TIMP-2 in human colorectal cancer--a predictor of tumour stage. PMID: 9310250 Ref: Expression and localization of matrix metalloproteinases and tissue inhibitors of metalloproteinases as a prognostic factor in advanced colorectal carcinomas. PMID: 21590124 |
Ref: The expression of MMP-2 and TIMP-2 in patients with colorectal adenocarcinoma invaded to the submucosal and proper muscle layer. PMID: 9468552 Ref: Short chain fatty acids inhibit human (SW1116) colon cancer cell invasion by reducing urokinase plasminogen activator activity and stimulating TIMP-1 and TIMP-2 activities, rather than via MMP modulation. PMID: 9695737 |
Ref: The expression of MMP-2 and TIMP-2 in patients with primary colorectal adenocarcinoma: correlation with liver metastasis. PMID: 10425288 Ref: Role of tissue inhibitors of metalloproteinases (TIMPs) in colorectal carcinoma. PMID: 10485622 Ref: Proteolysis in human breast and colorectal cancer. PMID: 10496354 |
Ref: Limited value of preoperative serum analyses of matrix metalloproteinases (MMP-2, MMP-9) and tissue inhibitors of matrix metalloproteinases (TIMP-1, TIMP-2) in colorectal cancer. PMID: 10810401 Ref: Activation of fibroblast-derived matrix metalloproteinase-2 by colon-cancer cells in non-contact Co-cultures. PMID: 10861469 Ref: Immunohistochemical detection of membrane-type-1-matrix metalloproteinase in colorectal carcinoma. PMID: 10901373 Ref: Matrix metalloproteinases, their tissue inhibitors and colorectal cancer staging. PMID: 10971431 Ref: [Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in colorectal neoplasm]. PMID: 11832095 |
Ref: AdTIMP-2 inhibits tumor growth, angiogenesis, and metastasis, and prolongs survival in mice. PMID: 11268284 Ref: Spectrum of matrix metalloproteinase expression in primary and metastatic colon cancer: relationship to the tissue inhibitors of metalloproteinases and membrane type-1-matrix metalloproteinase. PMID: 11401321 Ref: Increased matrix metalloproteinase 2 concentration and transcript expression in advanced colorectal carcinomas. PMID: 11459286 |
Ref: Comparison of matrix metalloproteinase expression between primary tumors with or without liver metastasis in pancreatic and colorectal carcinomas. PMID: 12173379 Ref: Balance between activation and inhibition of matrix metalloproteinase-2 (MMP-2) is altered in colorectal tumors compared to normal colonic epithelium. PMID: 12184536 |
Ref: The plasminogen activator and matrix metalloproteinase systems in colorectal cancer: relationship to tumour pathology. PMID: 12706368 Ref: Profiles of matrix metalloproteinases and their tissue inhibitors in intraperitoneal drainage fluid: relationship to wound healing. PMID: 12846914 Ref: Matrilysin (MMP-7) induces homotypic adhesion of human colon cancer cells and enhances their metastatic potential in nude mouse model. PMID: 14647460 |
Ref: Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers. PMID: 15623598 |
Ref: Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer. PMID: 15583811 Ref: Quantification of tissue inhibitor of metalloproteinases 2 in plasma from healthy donors and cancer patients. PMID: 15882437 Ref: Matrix metalloproteinase-2 and tissue inhibitor of metallo-proteinase-2 in colorectal carcinoma invasion and metastasis. PMID: 15918187 Ref: [The expression of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs) and angiogenesis in relation to the depth of tumor invasion and lymph node metastasis in submucosally invasive colorectal carcinoma]. PMID: 15973074 Ref: Effects of hepatocyte growth factor/scatter factor on the invasion of colorectal cancer cells in vitro. PMID: 15991286 Ref: Quantitative estimation of matrix metalloproteinases 2 and 7 (MMP-2, MMP-7) and tissue inhibitors of matrix metalloproteinases 1 and 2 (TIMP-1, TIMP-2) in colorectal carcinoma tissue samples. PMID: 16101153 Ref: Effect of a nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester on invasion of human colorectal cancer cell line SL-174T. PMID: 16419170 |
Ref: Prognostic value of E-cadherin, beta-catenin, MMPs (7 and 9), and TIMPs (1 and 2) in patients with colorectal carcinoma. PMID: 16425303 Ref: [Lymph node micrometastases and expression of metastasis-related gene proteins in patients with colorectal cancer]. PMID: 16635348 Ref: Activity and expression of urokinase-type plasminogen activator and matrix metalloproteinases in human colorectal cancer. PMID: 16916471 |
Ref: Clinicopathologic and prognostic significance of matrix metalloproteinases in rectal cancer. PMID: 16896992 Ref: Beneficial influence of microsatellite instability on gelatinase-tissue inhibitors of metalloproteinase balance in colorectal cancer. PMID: 17348445 Ref: MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties. PMID: 17513868 Ref: Clinicopathological assessment and quantitative estimation of the matrix metalloproteinases MMP-2 and MMP-7 and the inhibitors TIMP-1 and TIMP-2 in colorectal carcinoma tissue samples. PMID: 17649785 Ref: Imatinib inhibits colorectal cancer cell growth and suppresses stromal-induced growth stimulation, MT1-MMP expression and pro-MMP2 activation. PMID: 17721919 Ref: Inhibitory effects of retinoic acid and IIF on growth, migration and invasiveness in the U87MG human glioblastoma cell line. PMID: 17786368 Ref: The value and correlation between PRL-3 expression and matrix metalloproteinase activity and expression in human gliomas. PMID: 18021371 |
Ref: Gelatinase B expression as a prognostic factor in patients with stage II/III rectal carcinoma treated by postoperative adjuvant therapy. PMID: 18376229 Ref: TIMP-1 expression in human colorectal cancer is associated with TGF-B1, LOXL2, INHBA1, TNF-AIP6 and TIMP-2 transcript profiles. PMID: 19383344 |
Ref: Inhibition of hyaluronan synthases decreases matrix metalloproteinase-7 (MMP-7) expression and activity. PMID: 19231585 Ref: Differences in the gene expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in primary colorectal tumors and their synchronous liver metastases. PMID: 19331134 Ref: Analysis of differential gene expression in colorectal cancer and stroma using fluorescence-activated cell sorting purification. PMID: 19401702 Ref: [Effects of allicin on invasion and metastasis of colon cancer LoVo cell line in vitro]. PMID: 19671326 Ref: Inhibitory effects of tanshinone II-A on invasion and metastasis of human colon carcinoma cells. PMID: 19820721 Ref: PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin beta1-ERK1/2 and-MMP2 signaling. PMID: 19930715 Ref: Serum tissue inhibitor of metalloproteinase 1 and 2 (TIMP-1 and TIMP-2) levels in colorectal cancer patients: associations with clinicopathological variables and patient survival. PMID: 20108216 |
Ref: Effects of dietary beef and chicken with and without high amylose maize starch on blood malondialdehyde, interleukins, IGF-I, insulin, leptin, MMP-2, and TIMP-2 concentrations in rats. PMID: 20432166 Ref: Anti-proliferative and anti-cancer properties of Achyranthes aspera: specific inhibitory activity against pancreatic cancer cells. PMID: 20541002 Ref: Matrix metalloproteinases and tissue inhibitor of metalloproteinases are essential for the inflammatory response in cancer cells. PMID: 21152266 Ref: Evaluation of the expression of metalloproteinases 2 and 9 and their tissue inhibitors in colon cancer cells treated with phytic acid. PMID: 21229878 Ref: Matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases 2 in the diagnosis of colorectal adenoma and cancer patients. PMID: 21478099 |
Ref: Role of gelatinases (matrix metalloproteinases 2 and 9), vascular endothelial growth factor and endostatin on clinicopathological behaviour of rectal cancer. PMID: 19888958 Ref: Matrix metalloproteinase-9 is a prognostic marker to predict survival of patients who underwent surgery due to rectal carcinoma. PMID: 21212604 Ref: Clinical characteristics of TIMP2, MMP2, and MMP9 gene polymorphisms in colorectal cancer. PMID: 21261731 Ref: Pitavastatin inhibits hepatic steatosis and fibrosis in non-alcoholic steatohepatitis model rats. PMID: 21276150 Ref: EZH2 depletion blocks the proliferation of colon cancer cells. PMID: 21765901 |
Ref: The effect of inositol hexaphosphate on the expression of selected metalloproteinases and their tissue inhibitors in IL-1beta-stimulated colon cancer cells. PMID: 22415590 Ref: Anti-invasive effects and proapoptotic activity induction by the rexinoid IIF and valproic acid in combination on colon cancer cell lines. PMID: 22753748 Ref: Inhibitory effect of inositol hexaphosphate on metalloproteinases transcription in colon cancer cells stimulated with phorbol-12-myristate 13-acetate. PMID: 23285695 |
Ref: CD133 affects the invasive ability of HCT116 cells by regulating TIMP-2. PMID: 23195431 Ref: S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer. PMID: 23661436 Ref: Dual inhibition of EGFR and c-Met kinase activation by MJ-56 reduces metastasis of HT29 human colorectal cancer cells. PMID: 23677180 Ref: Phenethyl isothiocyanate suppresses EGF-stimulated SAS human oral squamous carcinoma cell invasion by targeting EGF receptor signaling. PMID: 23754208 Ref: Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRgamma activation. PMID: 24190430 |
Ref: Serum levels and tissue expression of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinases 2 (TIMP-2) in colorectal cancer patients. PMID: 24395652 Ref: Epithelial-mesenchymal transition in colorectal cancer tissue of patients with Lynch syndrome. PMID: 24415879 Ref: Upregulated miR-106a plays an oncogenic role in pancreatic cancer. PMID: 24444603 Ref: Luteolin inhibits matrix metalloproteinase 9 and 2 in azoxymethane-induced colon carcinogenesis. PMID: 24532706 Ref: EGFR and HER2 exert distinct roles on colon cancer cell functional properties and expression of matrix macromolecules. PMID: 24792576 |
Ref: The matrix metalloproteinase-7 and pro-enzyme of metalloproteinase-1 as a potential marker for patients with rectal cancer without distant metastasis. PMID: 25549795 Ref: TKTL1 promotes cell proliferation and metastasis in esophageal squamous cell carcinoma. PMID: 26349965 Ref: Colorectal cancer DNA methylation patterns from patients in Manaus, Brazil. PMID: 26363785 Ref: microRNA-20a enhances the epithelial-to-mesenchymal transition of colorectal cancer cells by modulating matrix metalloproteinases. PMID: 26622375 |
Ref: Clinicopathologic and Prognostic Significance of Metalloproteinase Tissue Inhibitor-2 Promoters in Tunisian Colorectal Cancer: A Case-Control Study. PMID: 26808125 Ref: Matrix metalloproteinases MMP1, MMP2, MMP9 and their tissue inhibitors TIMP1, TIMP2, TIMP3 in head and neck cancer: an immunohistochemical study. PMID: 27386931 |
Ref: The effectiveness of cyclooxygenase-2 inhibitors and evaluation of angiogenesis in the model of experimental colorectal cancer. PMID: 29562216 Ref: Downregulation of RPN2 induces apoptosis and inhibits migration and invasion in colon carcinoma. PMID: 29749494 Ref: Angiogenin and the MMP9-TIMP2 axis are up-regulated in proangiogenic, decidual NK-like cells from patients with colorectal cancer. PMID: 29763380 Ref: Knockdown of MON1B Exerts Anti-Tumor Effects in Colon Cancer In Vitro. PMID: 30368516 Ref: Cryptotanshinone inhibits the growth and invasion of colon cancer by suppressing inflammation and tumor angiogenesis through modulating MMP/TIMP system, PI3K/Akt/mTOR signaling and HIF-1alpha nuclear translocation. PMID: 30388517 |