Primary Site >> Colorectal Cancer
Gene >> TIMP1
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Ref: Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues. PMID: 2380196 |
Ref: Immunological quantitation of levels of tissue inhibitor of metalloproteinase-1 in human colon cancer. PMID: 1933883 |
Ref: Expression pattern of metalloproteinases and their inhibitors changes with the progression of human sporadic colorectal neoplasia. PMID: 8269281 |
Ref: The distribution of matrix metalloproteinases and tissue inhibitor of metalloproteinases in colorectal cancer. PMID: 7551259 Ref: Colon carcinoma cells with inactive nm23 show increased motility and response to motility factors. PMID: 7554087 Ref: [Significance of MMP-9 and TIMP-1 production during liver metastasis in colorectal cancer]. PMID: 7630024 Ref: Distinct pattern of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 mRNA expression in human colorectal cancer and liver metastases. PMID: 7669564 Ref: The distribution of matrix metalloproteinases and tissue inhibitor of metalloproteinases in colorectal cancer. PMID: 7780609 Ref: A fibroblast elongation factor purified from colon carcinoma cells shares sequence identity with TIMP-1. PMID: 7826376 Ref: Elevated tissue inhibitor of metalloproteinase 1 RNA in colorectal cancer stroma correlates with lymph node and distant metastases. PMID: 9816060 |
Ref: Suppression of in vivo tumor growth and induction of suspension cell death by tissue inhibitor of metalloproteinases (TIMP)-3. PMID: 8824499 Ref: Enhanced expression of tissue inhibitors of metalloproteinases in human colorectal tumors. PMID: 8895669 |
Ref: [Significance in gene expression of matrix metalloproteinase-9, urokinase-type plasminogen activator and tissue inhibitor of metalloproteinase for metastases of gastric and/or colo-rectal cancer]. PMID: 9263524 Ref: TIMP-3 induces cell death by stabilizing TNF-alpha receptors on the surface of human colon carcinoma cells. PMID: 9344510 Ref: Expression and localization of matrix metalloproteinases and tissue inhibitors of metalloproteinases as a prognostic factor in advanced colorectal carcinomas. PMID: 21590124 |
Ref: Identifying markers for pancreatic cancer by gene expression analysis. PMID: 9488584 Ref: Short chain fatty acids inhibit human (SW1116) colon cancer cell invasion by reducing urokinase plasminogen activator activity and stimulating TIMP-1 and TIMP-2 activities, rather than via MMP modulation. PMID: 9695737 |
Ref: Quantitation of TIMP-1 in plasma of healthy blood donors and patients with advanced cancer. PMID: 10408859 Ref: Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applications. PMID: 10415733 Ref: Role of tissue inhibitors of metalloproteinases (TIMPs) in colorectal carcinoma. PMID: 10485622 Ref: Proteolysis in human breast and colorectal cancer. PMID: 10496354 Ref: Proteolysis in colorectal cancer. PMID: 10621835 |
Ref: Limited value of preoperative serum analyses of matrix metalloproteinases (MMP-2, MMP-9) and tissue inhibitors of matrix metalloproteinases (TIMP-1, TIMP-2) in colorectal cancer. PMID: 10810401 Ref: Activation of fibroblast-derived matrix metalloproteinase-2 by colon-cancer cells in non-contact Co-cultures. PMID: 10861469 Ref: Matrix metalloproteinases, their tissue inhibitors and colorectal cancer staging. PMID: 10971431 Ref: Simultaneous measurement of soluble carcinoembryonic antigen and the tissue inhibitor of metalloproteinase TIMP1 serum levels for use as markers of pre-invasive to invasive colorectal cancer. PMID: 10999465 Ref: High preoperative plasma tissue inhibitor of metalloproteinase-1 levels are associated with short survival of patients with colorectal cancer. PMID: 11106246 Ref: Increased expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) in a more tumourigenic colon cancer cell line. PMID: 11113862 Ref: [Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in colorectal neoplasm]. PMID: 11832095 Ref: Plasma TIMP-1-a marker of metastasis in colorectal cancer. PMID: 23577994 |
Ref: Gene expression analysis in colorectal cancer using practical DNA array filter. PMID: 11227951 Ref: Clinicopathological significance of fibrotic capsule formation around liver metastasis from colorectal cancer. PMID: 11260865 Ref: Significance of cysteine rich transcription factor (CRTF) in the synthesis of tissue inhibitor of metalloproteinases 1 (TIMP-1) in gastrointestinal cancers. PMID: 11370821 Ref: Spectrum of matrix metalloproteinase expression in primary and metastatic colon cancer: relationship to the tissue inhibitors of metalloproteinases and membrane type-1-matrix metalloproteinase. PMID: 11401321 Ref: Increased matrix metalloproteinase 2 concentration and transcript expression in advanced colorectal carcinomas. PMID: 11459286 Ref: Imbalance between matrix metalloproteinase 9 and tissue inhibitor of metalloproteinases 1 expression by tumor cells implicated in liver metastasis from colorectal carcinoma. PMID: 11680936 Ref: Inhibition of liver metastasis from orthotopically implanted colon cancer in nude mice by transfection of the TIMP-1 gene into KM12SM cells. PMID: 11686557 Ref: Short-chain fatty acids inhibit invasive human colon cancer by modulating uPA, TIMP-1, TIMP-2, mutant p53, Bcl-2, Bax, p21 and PCNA protein expression in an in vitro cell culture model. PMID: 11694645 Ref: Plasma concentration of tissue inhibitor of matrix metalloproteinase 1 in patients with colorectal carcinoma. PMID: 11736971 Ref: [Effect of lidamycin on the expression of genes involved in invasion regulation in HCT-8 human colon cancer cells]. PMID: 12580049 |
Ref: Total levels of tissue inhibitor of metalloproteinases 1 in plasma yield high diagnostic sensitivity and specificity in patients with colon cancer. PMID: 11801553 Ref: Measurement of the noncomplexed free fraction of tissue inhibitor of metalloproteinases 1 in plasma by immunoassay. PMID: 12142388 |
Ref: Serum markers of matrix turnover as predictors for the evolution of colorectal cancer metastasis under chemotherapy. PMID: 12698191 Ref: The plasminogen activator and matrix metalloproteinase systems in colorectal cancer: relationship to tumour pathology. PMID: 12706368 Ref: Profiles of matrix metalloproteinases and their tissue inhibitors in intraperitoneal drainage fluid: relationship to wound healing. PMID: 12846914 Ref: Serum levels of tissue inhibitor of metalloproteinases-1 (TIMP-1) in colorectal cancer patients. PMID: 14669077 |
Ref: Association between preoperative plasma levels of tissue inhibitor of metalloproteinases 1 and rectal cancer patient survival. a validation study. PMID: 14687791 Ref: Prognostic impact of tissue inhibitor of matrix metalloproteinase-1 in plasma of patients with colorectal cancer. PMID: 15274408 Ref: Do aberrant crypt foci have predictive value for the occurrence of colorectal tumours? Potential of gene expression profiling in tumours. PMID: 15304309 Ref: Plasma TIMP-1 in patients with colorectal adenomas: a prospective study. PMID: 15341992 Ref: Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinases-1 in the liver: efficient protection against T-cell lymphoma and colon carcinoma metastasis. PMID: 15390257 Ref: Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers. PMID: 15623598 Ref: Advanced colorectal carcinomas measuring 20 mm or less exhibit markedly higher invasiveness despite their size. PMID: 15628723 |
Ref: Localization of tissue inhibitor of metalloproteinases 1 (TIMP-1) in human colorectal adenoma and adenocarcinoma. PMID: 15386409 Ref: Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer. PMID: 15583811 Ref: Gene expression profiling of colorectal adenomas and early invasive carcinomas by cDNA array analysis. PMID: 15785755 Ref: Establishment and characterization of 7 new monoclonal antibodies to tissue inhibitor of metalloproteinases-1. PMID: 15870512 Ref: [The expression of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs) and angiogenesis in relation to the depth of tumor invasion and lymph node metastasis in submucosally invasive colorectal carcinoma]. PMID: 15973074 Ref: Effects of hepatocyte growth factor/scatter factor on the invasion of colorectal cancer cells in vitro. PMID: 15991286 Ref: Quantitative estimation of matrix metalloproteinases 2 and 7 (MMP-2, MMP-7) and tissue inhibitors of matrix metalloproteinases 1 and 2 (TIMP-1, TIMP-2) in colorectal carcinoma tissue samples. PMID: 16101153 |
Ref: Etodolac, a selective cyclooxygenase-2 inhibitor, inhibits liver metastasis of colorectal cancer cells via the suppression of MMP-9 activity. PMID: 16391837 Ref: Prognostic value of E-cadherin, beta-catenin, MMPs (7 and 9), and TIMPs (1 and 2) in patients with colorectal carcinoma. PMID: 16425303 Ref: Altered plasma matrix metalloproteinase-9/tissue inhibitor of matrix [corrected] metalloproteinase-1 concentration during the early postoperative period in patients with colorectal cancer. PMID: 16432654 Ref: Impact of elective resection on plasma TIMP-1 levels in patients with colon cancer. PMID: 16466554 Ref: Circulating gelatinases and tissue inhibitor of metalloproteinase-1 in colorectal cancer metastatic liver disease. PMID: 16650961 Ref: [Expression of tissue inhibitor of metalloproteinase-1 in colorectal carcinoma and its clinical implications]. PMID: 16762889 Ref: Tissue inhibitor of metalloproteinases-1 in the postoperative monitoring of colorectal cancer. PMID: 16809030 Ref: Activity and expression of urokinase-type plasminogen activator and matrix metalloproteinases in human colorectal cancer. PMID: 16916471 Ref: Evaluation of an improved tissue inhibitor of metalloproteinase 1 dual monoclonal sandwich immunoassay. PMID: 17033201 Ref: Suppression effects of human recombinant tissue inhibitor of metalloproteinases-1(TIMP-1) on tumor proliferation using in vivo treatment model of well-differentiated colon cancer cell line, HT29. PMID: 17072372 Ref: Enhanced expression of MMP-7 and MMP-13 in inflammatory bowel disease: a precancerous potential? PMID: 17075343 |
Ref: Matrix metalloproteinase-9,-3 and tissue inhibitor of matrix metalloproteinase-1 in colorectal cancer: relationship to clinicopathological variables. PMID: 16615041 Ref: Plasma tissue inhibitor of metalloproteinases-1 as a biological marker? Pre-analytical considerations. PMID: 17328880 Ref: Beneficial influence of microsatellite instability on gelatinase-tissue inhibitors of metalloproteinase balance in colorectal cancer. PMID: 17348445 Ref: Prognostic significance of matrix metalloproteinases-1, -2, -7 and -13 and tissue inhibitors of metalloproteinases-1, -2, -3 and -4 in colorectal cancer. PMID: 17455256 Ref: MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties. PMID: 17513868 Ref: Investigation of tissue inhibitor of metalloproteinases 1 in plasma from colorectal cancer patients and blood donors by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. PMID: 17549663 Ref: Peroxisome proliferator-activated receptor gamma agonists inhibit the proliferation and invasion of human colon cancer cells. PMID: 17551074 Ref: Clinicopathological assessment and quantitative estimation of the matrix metalloproteinases MMP-2 and MMP-7 and the inhibitors TIMP-1 and TIMP-2 in colorectal carcinoma tissue samples. PMID: 17649785 Ref: Tissue inhibitor of metalloproteinase-1 levels in plasma from tumour arteries and veins of patients with rectal cancer. PMID: 17763191 Ref: Inhibitory effects of retinoic acid and IIF on growth, migration and invasiveness in the U87MG human glioblastoma cell line. PMID: 17786368 Ref: Impact of plasma tissue inhibitor of matrix metalloproteinase-1 on long-term survival in patients with colorectal cancer. PMID: 18160809 Ref: Identification of alternatively spliced TIMP-1 mRNA in cancer cell lines and colon cancer tissue. PMID: 19383295 |
Ref: Prognostic values of matrix metalloproteinase family expression in human colorectal carcinoma. PMID: 17543340 Ref: Functional proteomics study reveals that N-Acetylglucosaminyltransferase V reinforces the invasive/metastatic potential of colon cancer through aberrant glycosylation on tissue inhibitor of metalloproteinase-1. PMID: 17878270 Ref: A TIMP-1 splice variant transcript: possible role in regulation of TIMP-1 expression. PMID: 18180096 Ref: Investigating the biomarker potential of glycoproteins using comparative glycoprofiling - application to tissue inhibitor of metalloproteinases-1. PMID: 18206988 Ref: Comparative studies of tissue inhibitor of metalloproteinases-1 in plasma, serum and tumour tissue extracts from patients with primary colorectal cancer. PMID: 18224564 Ref: Plasma tissue inhibitor of metalloproteinases-1 (TIMP-1): a novel biological marker in the detection of primary colorectal cancer. Protocol outlines of the Danish-Australian endoscopy study group on colorectal cancer detection. PMID: 18224568 Ref: Gelatinase B expression as a prognostic factor in patients with stage II/III rectal carcinoma treated by postoperative adjuvant therapy. PMID: 18376229 Ref: Assessment of the biological variation of plasma tissue inhibitor of metalloproteinases-1. PMID: 18409150 Ref: Histone deacetylase inhibitors: the anticancer, antimetastatic and antiangiogenic activities of AN-7 are superior to those of the clinically tested AN-9 (Pivanex). PMID: 18506586 Ref: Biology and potential clinical implications of tissue inhibitor of metalloproteinases-1 in colorectal cancer treatment. PMID: 18584515 Ref: Invasion front-specific overexpression of tissue inhibitor of metalloproteinase-1 in liver metastases from colorectal cancer. PMID: 18630499 Ref: Improved diagnosis of colorectal cancer using a combination of fecal occult blood and novel fecal protein markers. PMID: 18928937 Ref: Irinophore C, a novel nanoformulation of irinotecan, alters tumor vascular function and enhances the distribution of 5-fluorouracil and doxorubicin. PMID: 19010842 Ref: TIMP-1 expression in human colorectal cancer is associated with TGF-B1, LOXL2, INHBA1, TNF-AIP6 and TIMP-2 transcript profiles. PMID: 19383344 |
Ref: Differences in the gene expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in primary colorectal tumors and their synchronous liver metastases. PMID: 19331134 Ref: Changes in plasma TIMP-1 levels after resection for primary colorectal cancer. PMID: 19331135 Ref: Low expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in glioblastoma predicts longer patient survival. PMID: 19430729 Ref: 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells. PMID: 19501039 Ref: [Tissue inhibitor of metalloproteinase-1 (TIMP-1) in colorectal cancer: correlation with clinico-morphological factors]. PMID: 19514370 Ref: Peritumoral administration of GPI-anchored TIMP-1 inhibits colon carcinoma growth in Rag-2 gamma chain-deficient mice. PMID: 19558322 Ref: Effective treatment of advanced colorectal cancer by rapamycin and 5-FU/oxaliplatin monitored by TIMP-1. PMID: 19565301 Ref: Quantitative analysis of an aberrant glycoform of TIMP1 from colon cancer serum by L-PHA-enrichment and SISCAPA with MRM mass spectrometry. PMID: 19645485 Ref: Inhibitory effects of tanshinone II-A on invasion and metastasis of human colon carcinoma cells. PMID: 19820721 Ref: Changes in cytokine and biomarker blood levels in patients with colorectal cancer during dendritic cell-based vaccination. PMID: 19863224 Ref: Serum tissue inhibitor of metalloproteinase 1 and 2 (TIMP-1 and TIMP-2) levels in colorectal cancer patients: associations with clinicopathological variables and patient survival. PMID: 20108216 |
Ref: Elevated intraperitoneal matrix metalloproteinases-8 and -9 in patients who develop anastomotic leakage after rectal cancer surgery: a pilot study. PMID: 19508511 Ref: A novel prognostic index in colorectal cancer defined by serum carcinoembryonic antigen and plasma tissue inhibitor of metalloproteinases-1. PMID: 20095885 Ref: A comparative study of protein expression in primary colorectal cancer and synchronous hepatic metastases: the significance of matrix metalloproteinase-1 expression as a predictor of liver metastasis. PMID: 20095886 Ref: Changes in soluble CEA and TIMP-1 levels during adjuvant chemotherapy for stage III colon cancer. PMID: 20150641 Ref: Comparative quantitation of aberrant glycoforms by lectin-based glycoprotein enrichment coupled with multiple-reaction monitoring mass spectrometry. PMID: 20462175 Ref: The diagnostic value of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) determination in the sera of colorectal adenoma and cancer patients. PMID: 20556397 Ref: Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas. PMID: 20572039 Ref: Preoperative plasma TIMP-1 is an independent prognostic indicator in patients with primary colorectal cancer: a prospective validation study. PMID: 20619633 Ref: Overexpression of MMP-13 gene in colorectal cancer with liver metastasis. PMID: 20683000 Ref: Expression of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinases 1 (TIMP-1) by colorectal cancer cells and adjacent stroma cells--associations with histopathology and patients outcome. PMID: 20801641 Ref: Dendritic cell vaccination of patients with metastatic colorectal cancer. PMID: 20816019 Ref: [Significance of plasmic L-plastin levels in the diagnosis of colorectal cancer]. PMID: 20878578 Ref: Overexpression of tissue inhibitor of metalloproteinase-1 gene correlates with poor outcomes in colorectal cancer. PMID: 21036730 Ref: Chemoradiation-induced changes in serum CEA and plasma TIMP-1 in patients with locally advanced rectal cancer. PMID: 21115936 Ref: Matrix metalloproteinases and tissue inhibitor of metalloproteinases are essential for the inflammatory response in cancer cells. PMID: 21152266 Ref: Evaluation of the expression of metalloproteinases 2 and 9 and their tissue inhibitors in colon cancer cells treated with phytic acid. PMID: 21229878 |
Ref: Plasma TIMP-1 and CEA in detection of primary colorectal cancer: a prospective, population based study of 4509 high-risk individuals. PMID: 20799911 Ref: Parameters of biological activity in colorectal cancer. PMID: 21273626 Ref: Pitavastatin inhibits hepatic steatosis and fibrosis in non-alcoholic steatohepatitis model rats. PMID: 21276150 Ref: Genetic patterns of metalloproteinases and their tissular inhibitors - clinicopathologic and prognostic significance in colorectal cancer. PMID: 21424059 Ref: Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs). PMID: 21763448 Ref: JNK suppression is essential for 17beta-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells. PMID: 21859479 Ref: Plasma or serum TIMP-1 is a predictor of survival outcomes in colorectal cancer: a meta-analysis. PMID: 21961097 Ref: Differences in plasma TIMP-1 levels between healthy people and patients with rectal cancer stage II or III. PMID: 22933958 Ref: Rosiglitazone and retinoic acid inhibit proliferation and induce apoptosis in the HCT-15 human colorectal cancer cell line. PMID: 22977519 |
Ref: Endothelin-1 stimulates colon cancer adjacent fibroblasts. PMID: 21445967 Ref: Identification of low-abundance cancer biomarker candidate TIMP1 from serum with lectin fractionation and peptide affinity enrichment by ultrahigh-resolution mass spectrometry. PMID: 22196688 Ref: p38alpha MAPK mediates 17beta-estradiol inhibition of MMP-2 and -9 expression and cell migration in human lovo colon cancer cells. PMID: 22377968 Ref: The effect of inositol hexaphosphate on the expression of selected metalloproteinases and their tissue inhibitors in IL-1beta-stimulated colon cancer cells. PMID: 22415590 Ref: Comparison and combination of blood-based inflammatory markers with faecal occult blood tests for non-invasive colorectal cancer screening. PMID: 22454079 Ref: Effect of the expression of matrix metalloproteases and their tissue inhibitors on survival of patients with resectable colorectal cancer. PMID: 22488635 Ref: Anti-invasive effects and proapoptotic activity induction by the rexinoid IIF and valproic acid in combination on colon cancer cell lines. PMID: 22753748 Ref: High levels of serum VEGF and TIMP-1 are correlated with colon cancer liver metastasis and intrahepatic recurrence after liver resection. PMID: 22807974 Ref: Overexpression and beta-1,6-N-acetylglucosaminylation-initiated aberrant glycosylation of TIMP-1: a "double whammy" strategy in colon cancer progression. PMID: 22859303 Ref: Saliva and plasma TIMP-1 in patients with colorectal cancer: a prospective study. PMID: 22871105 Ref: Limitations of tissue micro array in Duke's B colon cancer. PMID: 22958290 Ref: Evaluation of predictive markers for patients with advanced colorectal cancer. PMID: 22974092 Ref: Plasma TIMP1 level is a prognostic factor in patients with liver metastases. PMID: 23060593 Ref: Expression level and glycan dynamics determine the net effects of TIMP-1 on cancer progression. PMID: 23187000 Ref: The behavior of matrix metalloproteinases and their inhibitors in colorectal cancer. PMID: 23202950 Ref: Inhibitory effect of inositol hexaphosphate on metalloproteinases transcription in colon cancer cells stimulated with phorbol-12-myristate 13-acetate. PMID: 23285695 |
Ref: Liver acid sphingomyelinase inhibits growth of metastatic colon cancer. PMID: 23298833 Ref: Prognostic role of tumor-associated proteases in colorectal cancer. PMID: 23484202 Ref: Detection of cadherin-17 in human colon cancer LIM1215 cell secretome and tumour xenograft-derived interstitial fluid and plasma. PMID: 23557862 Ref: Tissue inhibitor of metalloproteinases-1 as a biological marker in colorectal cancer: influence of smoking on plasma levels? PMID: 23592002 Ref: Dual inhibition of EGFR and c-Met kinase activation by MJ-56 reduces metastasis of HT29 human colorectal cancer cells. PMID: 23677180 Ref: Phenethyl isothiocyanate suppresses EGF-stimulated SAS human oral squamous carcinoma cell invasion by targeting EGF receptor signaling. PMID: 23754208 Ref: The correlation between the levels of tissue inhibitor of metalloproteinases 1 in plasma and tumour response and survival after preoperative radiochemotherapy in patients with rectal cancer. PMID: 23801910 Ref: TIMP-1 increases expression and phosphorylation of proteins associated with drug resistance in breast cancer cells. PMID: 23909892 Ref: [Expression of molecular markers detected by immunohistochemistry and risk of lymph node metastasis in stage T1 and T2 colorecrectal cancers]. PMID: 23985256 Ref: [Clinical prospects of tumor-associated proteases and their tissue inhibitors investigation in oncologic patient]. PMID: 24000664 Ref: TIMP-1 promotes accumulation of cancer associated fibroblasts and cancer progression. PMID: 24143225 Ref: Comparison of protein immunoprecipitation-multiple reaction monitoring with ELISA for assay of biomarker candidates in plasma. PMID: 24224610 Ref: Tumor associated proteases -- prognostic markers of colorectal cancer. PMID: 24640092 |
Ref: Positron emission tomography/computed tomography for optimized colon cancer staging and follow up. PMID: 24286594 Ref: Predicting the pathologic response of locally advanced rectal cancer to neoadjuvant concurrent chemoradiation using enzyme-linked immunosorbent assays (ELISAs) for biomarkers. PMID: 24390211 Ref: A gene expression and pre-mRNA splicing signature that marks the adenoma-adenocarcinoma progression in colorectal cancer. PMID: 24516561 Ref: EGFR and HER2 exert distinct roles on colon cancer cell functional properties and expression of matrix macromolecules. PMID: 24792576 Ref: Enhanced anti-colorectal cancer effects of carfilzomib combined with CPT-11 via downregulation of nuclear factor-kappaB in vitro and in vivo. PMID: 24968890 Ref: Pair-wise comparison analysis of differential expression of mRNAs in early and advanced stage primary colorectal adenocarcinomas. PMID: 25107436 Ref: TIMP-1: a strong player in colorectal cancer. PMID: 25531992 Ref: TIMP-1 expression in human colorectal cancer is associated with SMAD3 gene expression levels: a pilot study. PMID: 25532000 Ref: Diagnostic significance of TIMP-1 level in serum and its immunohistochemical expression in colorectal cancer patients. PMID: 25693084 Ref: Predictive value of tissue inhibitor of metalloproteinases-1 and carcinoembryonic antigen plasma levels in response to chemotherapy in patients with metastatic colorectal cancer. PMID: 25709652 |
Ref: Targeting colon cancer cell NF-kappaB promotes an anti-tumour M1-like macrophage phenotype and inhibits peritoneal metastasis. PMID: 24704833 Ref: Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice. PMID: 25131778 Ref: A randomized pilot study on single-port versus conventional laparoscopic rectal surgery: effects on postoperative pain and the stress response to surgery. PMID: 25380743 Ref: The matrix metalloproteinase-7 and pro-enzyme of metalloproteinase-1 as a potential marker for patients with rectal cancer without distant metastasis. PMID: 25549795 Ref: TIMP-1 and CEA as biomarkers in third-line treatment with irinotecan and cetuximab for metastatic colorectal cancer. PMID: 25608838 Ref: Quantitative analysis of low-abundance serological proteins with peptide affinity-based enrichment and pseudo-multiple reaction monitoring by hybrid quadrupole time-of-flight mass spectrometry. PMID: 26043090 Ref: Molecular targets and pathways involved in liver metastasis of colorectal cancer. PMID: 26104118 Ref: Plasma TIMP-1 and CEA as Markers for Detection of Primary Colorectal Cancer: A Prospective Validation Study Including Symptomatic and Non-symptomatic Individuals. PMID: 26254391 Ref: Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array. PMID: 26258407 Ref: Blood-based Biomarkers at Large Bowel Endoscopy and Prediction of Future Malignancies. PMID: 26526637 Ref: Expressions of TIMP-1, COX-2 and MMP-7 in Colon Polyp and Colon Cancer. PMID: 29201696 |
Ref: Tissue inhibitor of matrix metalloproteinase-1 expression in colorectal cancer liver metastases is associated with vascular structures. PMID: 25594187 Ref: Clinicopathologic and Prognostic Significance of Metalloproteinase Tissue Inhibitor-2 Promoters in Tunisian Colorectal Cancer: A Case-Control Study. PMID: 26808125 Ref: Increased serological cancer-associated biomarker levels at large bowel endoscopy and risk of subsequent primary cancer (dagger). PMID: 26918701 Ref: Expression of Migration-Related Genes in Human Colorectal Cancer and Activity of a Disintegrin and Metalloproteinase 17. PMID: 27110571 Ref: Detection of Biomarkers with Solid-Phase Proximity Ligation Assay in Patients with Colorectal Cancer. PMID: 27267845 Ref: Distinct Transcriptional Changes and Epithelial-Stromal Interactions Are Altered in Early-Stage Colon Cancer Development. PMID: 27353028 Ref: Matrix metalloproteinases MMP1, MMP2, MMP9 and their tissue inhibitors TIMP1, TIMP2, TIMP3 in head and neck cancer: an immunohistochemical study. PMID: 27386931 Ref: TIMP-1 is under regulation of the EGF signaling axis and promotes an aggressive phenotype in KRAS-mutated colorectal cancer cells: a potential novel approach to the treatment of metastatic colorectal cancer. PMID: 27509063 Ref: TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway. PMID: 27644693 Ref: Combination of three-gene immunohistochemical panel and magnetic resonance imaging-detected extramural vascular invasion to assess prognosis in non-advanced rectal cancer patients. PMID: 27784970 |
Ref: TUC.338 promotes invasion and metastasis in colorectal cancer. PMID: 27914101 Ref: Detection of colorectal neoplasia: Combination of eight blood-based, cancer-associated protein biomarkers. PMID: 27935033 Ref: Evaluation on biological compatibility of carboxymethyl chitosan as biomaterials for antitumor drug delivery. PMID: 28077049 Ref: Profile of Expression of Genes Encoding Matrix Metallopeptidase 9 (MMP9), Matrix Metallopeptidase 28 (MMP28) and TIMP Metallopeptidase Inhibitor 1 (TIMP1) in Colorectal Cancer: Assessment of the Role in Diagnosis and Prognostication. PMID: 28293015 Ref: Anticancer activity of Nelumbo nucifera stamen extract in human colon cancer HCT-116 cells in vitro. PMID: 28454279 Ref: Identification of molecular characteristics induced by radiotherapy in rectal cancer based on microarray data. PMID: 28454466 Ref: Predicting Outcome and Therapy Response in mCRC Patients Using an Indirect Method for CTCs Detection by a Multigene Expression Panel: A Multicentric Prospective Validation Study. PMID: 28608814 Ref: Ca(2+)/calmodulin-dependent protein kinase II regulates colon cancer proliferation and migration via ERK1/2 and p38 pathways. PMID: 28970726 Ref: Prediction and Validation of Hub Genes Associated with Colorectal Cancer by Integrating PPI Network and Gene Expression Data. PMID: 29209625 |
Ref: Anti-cancer effect of Aquaporin 5 silencing in colorectal cancer cells in association with inhibition of Wnt/beta-catenin pathway. PMID: 29455395 Ref: Genistein inhibits invasion and migration of colon cancer cells by recovering WIF1 expression. PMID: 29568950 Ref: Role of matrix metalloproteinases in tumour invasion: immunohistochemistry of peritoneum from peritoneal carcinomatosis. PMID: 29623449 Ref: Analysis of potential genes and pathways associated with the colorectal normal mucosa-adenoma-carcinoma sequence. PMID: 29659199 Ref: Angiogenin and the MMP9-TIMP2 axis are up-regulated in proangiogenic, decidual NK-like cells from patients with colorectal cancer. PMID: 29763380 Ref: Interrogation of transcriptomic changes associated with drug-induced hepatic sinusoidal dilatation in colorectal cancer. PMID: 29879147 Ref: Serum MMP-8 and TIMP-1 predict prognosis in colorectal cancer. PMID: 29929486 Ref: [How to predict the relapse after surgery or radiofrequency of liver metastases of colorectal cancer? Interest of the serum kinetic variation of a matrix metalloproteinase cluster]. PMID: 30243479 Ref: Cryptotanshinone inhibits the growth and invasion of colon cancer by suppressing inflammation and tumor angiogenesis through modulating MMP/TIMP system, PI3K/Akt/mTOR signaling and HIF-1alpha nuclear translocation. PMID: 30388517 |