Primary Site >> Colorectal Cancer

Gene >> TDG

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Ref: Initiation of strand incision at G:T and O(6)-methylguanine:T base mismatches in DNA by human cell extracts.
PMID: 11376160
Ref: Thymine DNA glycosylase.
PMID: 11554300
Ref: Multiplicity of strand incision at G:T base mismatches in DNA by human cell extracts.
PMID: 15157103
Ref: Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition.
PMID: 17029639
Ref: Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations.
PMID: 21537397
Ref: Unique mutational profile associated with a loss of TDG expression in the rectal cancer of a patient with a constitutional PMS2 deficiency.
PMID: 22608206
Ref: Transcriptional regulation of thymine DNA glycosylase (TDG) by the tumor suppressor protein p53.
PMID: 23165212
Ref: Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk.
PMID: 22961839
Ref: Acidic tumor microenvironment downregulates hMLH1 but does not diminish 5-fluorouracil chemosensitivity.
PMID: 23643670
Ref: 8-Oxo-7,8-dihydroguanine and uric acid as efficient predictors of survival in colon cancer patients.
PMID: 23832862
Ref: Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer.
PMID: 24532795
Ref: Thymine DNA glycosylase promotes transactivation of beta-catenin/TCFs by cooperating with CBP.
PMID: 24748645
Ref: Enigmatic 5-hydroxymethyluracil: Oxidatively modified base, epigenetic mark or both?
PMID: 27036066
Ref: Thymine DNA Glycosylase (TDG) is involved in the pathogenesis of intestinal tumors with reduced APC expression.
PMID: 29163805