Primary Site >> Stomach Cancer
Gene >> STAT3
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Ref: Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway. PMID: 12555068 |
Ref: STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. PMID: 15077160 Ref: Constitutional activation of IL-6-mediated JAK/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell line. PMID: 15354212 Ref: [Constitutive activation and clinical significance of Stat3 in human gastric cancer tissues and cell lines]. PMID: 15730617 Ref: [The impact of decreased Stat3 activation on 5-fluorouracil resistance of human gastric cancer cell line]. PMID: 15730734 |
Ref: Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma. PMID: 15735748 Ref: Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer. PMID: 15746037 Ref: Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation. PMID: 15882975 Ref: Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130. PMID: 16143138 |
Ref: Phospho-Stat3 expression and correlation with VEGF, p53, and Bcl-2 in gastric carcinoma using tissue microarray. PMID: 16948814 Ref: STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis. PMID: 17030178 |
Ref: Expression of p-STAT3 in human gastric carcinoma: significant correlation in tumour invasion and prognosis. PMID: 17203226 Ref: (-)-Epigallocatechin-3-gallate inhibits growth of gastric cancer by reducing VEGF production and angiogenesis. PMID: 17451194 Ref: [Effects of Chinese herbal recipe Weichang'an in inducing apoptosis and related gene expression in human gastric cancer grafted onto nude mice]. PMID: 17498489 Ref: Augmented gp130-mediated cytokine signalling accompanies human gastric cancer progression. PMID: 17724739 Ref: [Difference of gene expression profile in human gastric cancer grafted onto nude mice treated with WCA]. PMID: 18161298 Ref: Expression of seven gastric cancer-associated genes and its relevance for Wnt, NF-kappaB and Stat3 signaling. PMID: 18184402 |
Ref: REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells. PMID: 18024479 Ref: Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin. PMID: 18097546 Ref: Effects of Wei Chang An on expression of multiple genes in human gastric cancer grafted onto nude mice. PMID: 18205257 Ref: Signal transduction proteins in tumors from Puerto Rican and Caucasian gastric adenocarcinoma patients: expression differences with potential for specific targeted therapies. PMID: 18224443 Ref: What lurks beneath: IL-11, via Stat3, promotes inflammation-associated gastric tumorigenesis. PMID: 18431518 Ref: STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. PMID: 18431520 Ref: Inverse association between Raf Kinase Inhibitory Protein and signal transducers and activators of transcription 3 expression in gastric adenocarcinoma patients: implications for clinical outcome. PMID: 18483365 Ref: IL-6 induces MUC4 expression through gp130/STAT3 pathway in gastric cancer cell lines. PMID: 18573283 Ref: Role of STAT3 as a negative regulator in Mac2- binding protein expression. PMID: 18594176 |
Ref: Stat3 is involved in angiotensin II-induced expression of MMP2 in gastric cancer cells. PMID: 19082717 Ref: [Epigallocatechin-3-gallate inhibits growth and angiogenesis of gastric cancer and its molecular mechanism]. PMID: 19145512 Ref: Chemokine receptor CXCR4 expression, function, and clinical implications in gastric cancer. PMID: 19148483 Ref: STAT3 expression in gastric cancer indicates a poor prognosis. PMID: 19175826 Ref: Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma. PMID: 19339266 Ref: STAT3 as a prognostic marker in human gastric cancer. PMID: 19368630 Ref: Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades. PMID: 19424602 Ref: Expression of activated signal transducer and activator of transcription 3 predicts poor clinical outcome in gastric adenocarcinoma. PMID: 19664131 Ref: Cytokine signalling via gp130 in gastric cancer. PMID: 19665497 |
Ref: Inflammation modulates the expression of the intestinal mucins MUC2 and MUC4 in gastric tumors. PMID: 20062084 Ref: Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions. PMID: 20128024 Ref: Helicobacter pylori CagA phosphorylation status determines the gp130-activated SHP2/ERK and JAK/STAT signal transduction pathways in gastric epithelial cells. PMID: 20348091 Ref: KRAS mutant lung cancer cells are differentially responsive to MEK inhibitor due to AKT or STAT3 activation: implication for combinatorial approach. PMID: 20358631 Ref: Epstein-Barr virus and gastric carcinoma. PMID: 20518883 Ref: Differential interleukin-6/Stat3 signaling as a function of cellular context mediates Ras-induced transformation. PMID: 20929542 Ref: Catecholamine up-regulates MMP-7 expression by activating AP-1 and STAT3 in gastric cancer. PMID: 20939893 Ref: STAT-3 correlates with lymph node metastasis and cell survival in gastric cancer. PMID: 21072904 |
Ref: PIAS3 expression in human gastric carcinoma and its adjacent non-tumor tissues. PMID: 21334998 Ref: (-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer. PMID: 21633597 Ref: The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17. PMID: 21710691 Ref: Differential roles of STAT3 depending on the mechanism of STAT3 activation in gastric cancer cells. PMID: 21730976 Ref: [(-)-Epigallocatechin-3-gallate reduces vascular endothelial growth factor expression in gastric cancer cells via suppressing activity]. PMID: 21866460 Ref: The effects of recombinant human GH on promoting tumor growth depend on the expression of GH receptor in vivo. PMID: 21920991 Ref: Epstein-Barr virus-associated gastric carcinoma. PMID: 21944426 Ref: Eupatilin Inhibits Gastric Cancer Cell Growth by Blocking STAT3-Mediated VEGF Expression. PMID: 22076197 Ref: Constitutive activation of signal transducers and activators of transcription 3 correlates with better prognosis, cell proliferation and hypoxia-inducible factor-1alpha in human gastric cancer. PMID: 22104200 Ref: Contribution of gut microbiota to colonic and extracolonic cancer development. PMID: 22179211 Ref: Prognostic value of co-expression of STAT3, mTOR and EGFR in gastric cancer. PMID: 22977493 Ref: Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis. PMID: 24212943 |
Ref: Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth. PMID: 22030090 Ref: Antiproliferative effect of SOCS-1 through the suppression of STAT3 and p38 MAPK activation in gastric cancer cells. PMID: 22095154 Ref: Inhibition of activated Stat3 reverses drug resistance to chemotherapeutic agents in gastric cancer cells. PMID: 22104727 Ref: Evaluation of the antitumor effects and mechanisms of PF00299804, a pan-HER inhibitor, alone or in combination with chemotherapy or targeted agents in gastric cancer. PMID: 22135232 Ref: NVP-BKM120, a novel PI3K inhibitor, shows synergism with a STAT3 inhibitor in human gastric cancer cells harboring KRAS mutations. PMID: 22159814 Ref: Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer. PMID: 22203730 Ref: [Quercetin affects leptin and its receptor in human gastric cancer MGC-803 cells and JAK-STAT pathway]. PMID: 22230496 Ref: Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10. PMID: 22285823 Ref: MiR-135a targets JAK2 and inhibits gastric cancer cell proliferation. PMID: 22310976 Ref: Constitutive activation of STAT3 is predictive of poor prognosis in human gastric cancer. PMID: 22328012 Ref: STAT3 silencing enhances the efficacy of the HSV.tk suicide gene in gastrointestinal cancer therapy. PMID: 22350508 Ref: Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-alpha. PMID: 22351606 Ref: Expression of STAT3, MMP-1 and TIMP-1 in gastric cancer and correlation with pathological features. PMID: 22469989 Ref: Correlation of epigenetic aberrance with STAT3 signaling pathway in gastric carcinogenesis. PMID: 22562532 Ref: Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression. PMID: 22581828 Ref: Resistance to TRAIL is mediated by DARPP-32 in gastric cancer. PMID: 22589394 Ref: Targeting STAT3 in gastric cancer. PMID: 22834702 Ref: Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice. PMID: 22937084 Ref: STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation. PMID: 23079657 Ref: [Epstein-Barr virus and gastric carcinoma]. PMID: 23198550 |
Ref: Recombinant human leptin induces growth inhibition and apoptosis in human gastric cancer MGC-803 cells. PMID: 23001141 Ref: GRIM-19 inhibits the STAT3 signaling pathway and sensitizes gastric cancer cells to radiation. PMID: 23124042 Ref: MicroRNA-18a modulates STAT3 activity through negative regulation of PIAS3 during gastric adenocarcinogenesis. PMID: 23322197 Ref: STAT3 interacts with Skp2/p27/p21 pathway to regulate the motility and invasion of gastric cancer cells. PMID: 23333463 Ref: Gastrin acting on the cholecystokinin2 receptor induces cyclooxygenase-2 expression through JAK2/STAT3/PI3K/Akt pathway in human gastric cancer cells. PMID: 23376640 Ref: Expression of AFP and STAT3 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in AFP-producing gastric cancer cells. PMID: 23382965 Ref: A synergistic interaction between transcription factors nuclear factor-kappaB and signal transducers and activators of transcription 3 promotes gastric cancer cell migration and invasion. PMID: 23402362 Ref: OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells. PMID: 23402820 Ref: Sunitinib reverse multidrug resistance in gastric cancer cells by modulating Stat3 and inhibiting P-gp function. PMID: 23471661 Ref: Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets. PMID: 23520544 Ref: Overexpression of AKT decreases the chemosensitivity of gastric cancer cells to cisplatin in vitro and in vivo. PMID: 23546174 Ref: Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis. PMID: 23593346 Ref: [Effects of xinwei granule on STAT3 and p-STAT3 signal pathway in rats with precancerous lesion of gastric cancer]. PMID: 23596790 Ref: Catecholamine-Induced beta2-adrenergic receptor activation mediates desensitization of gastric cancer cells to trastuzumab by upregulating MUC4 expression. PMID: 23630346 Ref: IL-26 promotes the proliferation and survival of human gastric cancer cells by regulating the balance of STAT1 and STAT3 activation. PMID: 23704922 Ref: [Effect of rhGH on JAK2-STAT3 signal pathway after GHR was down-regulated by siRNA in gastric cancer cell]. PMID: 23724661 Ref: Epstein-Barr virus-encoded small non-coding RNAs induce cancer cell chemoresistance and migration. PMID: 23791019 Ref: STAT3 is associated with lymph node metastasis in gastric cancer. PMID: 23824569 Ref: Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: the role of IL-6 signaling and Nrf2/AKR1C axis identification. PMID: 23933386 Ref: Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. PMID: 23948300 Ref: Proton pump inhibitor selectively suppresses proliferation and restores the chemosensitivity of gastric cancer cells by inhibiting STAT3 signaling pathway. PMID: 23973653 Ref: Activation of STAT3 in human gastric cancer cells via interleukin (IL)-6-type cytokine signaling correlates with clinical implications. PMID: 24116074 |
Ref: Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice. PMID: 23178499 Ref: Obesity accelerates Helicobacter felis-induced gastric carcinogenesis by enhancing immature myeloid cell trafficking and TH17 response. PMID: 23729675 Ref: Testican-1-mediated epithelial-mesenchymal transition signaling confers acquired resistance to lapatinib in HER2-positive gastric cancer. PMID: 23873022 Ref: Caveolin-1 promotes gastric cancer progression by up-regulating epithelial to mesenchymal transition by crosstalk of signalling mechanisms under hypoxic condition. PMID: 24070739 Ref: A positive feedback loop between STAT3 and cyclooxygenase-2 gene may contribute to Helicobacter pylori-associated human gastric tumorigenesis. PMID: 24127267 Ref: CD24 mediates gastric carcinogenesis and promotes gastric cancer progression via STAT3 activation. PMID: 24327257 Ref: Genetic regulation of MUC1 expression by Helicobacter pylori in gastric cancer cells. PMID: 24491543 Ref: Interleukin-11 induces the expression of matrix metalloproteinase 13 in gastric cancer SCH cells partly via the PI3K-AKT and JAK-STAT3 pathways. PMID: 24504547 Ref: Signal transducer and activator of transcription 3 signaling upregulates fascin via nuclear factor-kappaB in gastric cancer: Implications in cell invasion and migration. PMID: 24527098 Ref: The role of leptin in gastric cancer: clinicopathologic features and molecular mechanisms. PMID: 24569072 Ref: STAT3 activation in tumor cell-free lymph nodes predicts a poor prognosis for gastric cancer. PMID: 24696730 Ref: Dynamic reprogramming of signaling upon met inhibition reveals a mechanism of drug resistance in gastric cancer. PMID: 24757178 Ref: Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo. PMID: 24804649 Ref: Activation of mesenchymal stem cells by macrophages prompts human gastric cancer growth through NF-kappaB pathway. PMID: 24824968 Ref: Novel role of toll-like receptors in Helicobacter pylori - induced gastric malignancy. PMID: 24833854 Ref: rs744166 polymorphism of the STAT3 gene is associated with risk of gastric cancer in a Chinese population. PMID: 24864251 Ref: Altered expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and its regulatory genes in gastric cancer tissues. PMID: 24927122 Ref: IL-22 produced by cancer-associated fibroblasts promotes gastric cancer cell invasion via STAT3 and ERK signaling. PMID: 24937671 Ref: The IL-6-STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression. PMID: 24946088 Ref: CDX2 can be regulated through the signalling pathways activated by IL-6 in gastric cells. PMID: 24953186 Ref: Systems modeling of the role of interleukin-21 in the maintenance of effector CD4+ T cell responses during chronic Helicobacter pylori infection. PMID: 25053783 Ref: Silibinin inhibits proliferation, induces apoptosis and causes cell cycle arrest in human gastric cancer MGC803 cells via STAT3 pathway inhibition. PMID: 25169527 Ref: Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression. PMID: 25327561 Ref: Correlation of RKIP, STAT3 and cyclin D1 expression in pathogenesis of gastric cancer. PMID: 25337233 Ref: Helicobacter pylori-induced STAT3 activation and signalling network in gastric cancer. PMID: 25594045 Ref: Role of Raf kinase inhibitor protein in Helicobacter pylori-mediated signaling in gastric cancer. PMID: 25597356 Ref: STAT3 regulation the expression of VEGF-D in HGC-27 gastric cancer cell. PMID: 25628786 Ref: SIRT1 counteracted the activation of STAT3 and NF-kappaB to repress the gastric cancer growth. PMID: 25664004 |
Ref: Bidirectional regulation between TMEFF2 and STAT3 may contribute to Helicobacter pylori-associated gastric carcinogenesis. PMID: 24996057 Ref: Piperine inhibits IL-1beta-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cells. PMID: 25234193 Ref: A MDM2-dependent positive-feedback loop is involved in inhibition of miR-375 and miR-106b induced by Helicobacter pylori lipopolysaccharide. PMID: 25307786 Ref: Inhibition of beta-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo. PMID: 25331984 Ref: Twist1 is a key regulator of cancer-associated fibroblasts. PMID: 25368021 Ref: Overexpression of SMYD3 was associated with increased STAT3 activation in gastric cancer. PMID: 25471787 Ref: Kurarinone Synergizes TRAIL-Induced Apoptosis in Gastric Cancer Cells. PMID: 25524636 Ref: IL-1RT1 signaling antagonizes IL-11 induced STAT3 dependent cardiac and antral stomach tumor development through myeloid cell enrichment. PMID: 25528766 Ref: Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma. PMID: 25588213 Ref: miR-874 functions as a tumor suppressor by inhibiting angiogenesis through STAT3/VEGF-A pathway in gastric cancer. PMID: 25596740 Ref: CXCL1 promotes tumor growth through VEGF pathway activation and is associated with inferior survival in gastric cancer. PMID: 25641338 Ref: Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/Notch positive feedback loop. PMID: 25669984 Ref: Myeloid cell leukemia-1 regulates the cell growth and predicts prognosis in gastric cancer. PMID: 25672320 Ref: Phase I Study of OPB-31121, an Oral STAT3 Inhibitor, in Patients with Advanced Solid Tumors. PMID: 25715763 Ref: Prognostic and clinical significance of STAT3 and MMP9 in patients with gastric cancer: a meta-analysis of a Chinese cohort. PMID: 25785029 Ref: PIAS3, an inhibitor of STAT3, has intensively negative association with the survival of gastric cancer. PMID: 25785044 Ref: Antitumorigenic effect of plumbagin by induction of SH2-containing protein tyrosine phosphatase 1 in human gastric cancer cells. PMID: 25815436 Ref: The Lauren classification highlights the role of epithelial-to-mesenchymal transition in gastric carcinogenesis: an immunohistochemistry study of the STAT3 and adhesion molecules expression. PMID: 25822437 Ref: Signal transducers and activators of transcription 3-induced metastatic potential in gastric cancer cells is enhanced by glycogen synthase kinase-3beta. PMID: 25846563 Ref: Netrin-4 as a biomarker promotes cell proliferation and invasion in gastric cancer. PMID: 25909166 Ref: Argininosuccinate synthetase 1 suppression and arginine restriction inhibit cell migration in gastric cancer cell lines. PMID: 25928182 Ref: Wogonin Inhibits Tumor-derived Regulatory Molecules by Suppressing STAT3 Signaling to Promote Tumor Immunity. PMID: 25962106 Ref: Fas Signaling Promotes Gastric Cancer Metastasis through STAT3-Dependent Upregulation of Fascin. PMID: 25992623 Ref: Prognostic Role of Phospho-STAT3 in Patients with Cancers of the Digestive System: A Systematic Review and Meta-Analysis. PMID: 26024373 Ref: Anti-Warburg effect of rosmarinic acid via miR-155 in gastric cancer cells. PMID: 26056431 Ref: Paeoniflorin inhibits human gastric carcinoma cell proliferation through up-regulation of microRNA-124 and suppression of PI3K/Akt and STAT3 signaling. PMID: 26109806 Ref: The Pharmacological Effects of S-Propargyl-Cysteine, a Novel Endogenous H2S-Producing Compound. PMID: 26162842 Ref: STAT3 polymorphism and Helicobacter pylori CagA strains with higher number of EPIYA-C segments independently increase the risk of gastric cancer. PMID: 26186918 Ref: Chronic inflammation and the development of malignancy in the GI tract. PMID: 26194796 Ref: [Retraction] Interleukin-11 induces the expression of matrix metalloproteinase 13 in gastric cancer SCH cells partly via the PI3K-AKT and JAK-STAT3 pathways. PMID: 26238072 Ref: Isoprenaline induces epithelial-mesenchymal transition in gastric cancer cells. PMID: 26253173 Ref: Dietary prevention of Helicobacter pylori-associated gastric cancer with kimchi. PMID: 26317548 Ref: Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer. PMID: 26359459 Ref: The G-protein-coupled bile acid receptor Gpbar1 (TGR5) suppresses gastric cancer cell proliferation and migration through antagonizing STAT3 signaling pathway. PMID: 26417930 Ref: Stat3-siRNA inhibits the growth of gastric cancer in vitro and in vivo. PMID: 26486443 Ref: Berberine and Curcumin Target Survivin and STAT3 in Gastric Cancer Cells and Synergize Actions of Standard Chemotherapeutic 5-Fluorouracil. PMID: 26492225 Ref: Tumor suppressor microRNA-31 inhibits gastric carcinogenesis by targeting Smad4 and SGPP2. PMID: 26494556 Ref: miR-27b-3p suppresses cell proliferation through targeting receptor tyrosine kinase like orphan receptor 1 in gastric cancer. PMID: 26576539 Ref: Expression analysis of apolipoprotein E and its associated genes in gastric cancer. PMID: 26622669 Ref: Hydroxyflavanone inhibits gastric carcinoma MGC-803 cell proliferation. PMID: 26629250 Ref: Overexpression of STAT3/pSTAT3 was associated with poor prognosis in gastric cancer: a meta-analysis. PMID: 26884913 |
Ref: Gastric tumour-derived ANGPT2 regulation by DARPP-32 promotes angiogenesis. PMID: 25779598 Ref: Silencing of FGFR4 could influence the biological features of gastric cancer cells and its therapeutic value in gastric cancer. PMID: 26432329 Ref: Epigenetic regulation and anti-tumorigenic effects of SH2-containing protein tyrosine phosphatase 1 (SHP1) in human gastric cancer cells. PMID: 26508024 Ref: IL-17 promotes tumor angiogenesis through Stat3 pathway mediated upregulation of VEGF in gastric cancer. PMID: 26566627 Ref: IL-6 mediates the signal pathway of JAK-STAT3-VEGF-C promoting growth, invasion and lymphangiogenesis in gastric cancer. PMID: 26750536 Ref: CCL5 secreted by tumor associated macrophages may be a new target in treatment of gastric cancer. PMID: 26796278 Ref: Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model. PMID: 26837764 Ref: Leptin receptor signaling is required for high-fat diet-induced atrophic gastritis in mice. PMID: 26839577 Ref: Prognostic Value and Clinicopathological Significance of p-stat3 Among Gastric Carcinoma Patients: A Systematic Review and Meta-Analysis. PMID: 26844481 Ref: STAT3 is Overactivated in Gastric Cancer Stem-Like Cells. PMID: 26862521 Ref: Low nanomolar concentrations of Cucurbitacin-I induces G2/M phase arrest and apoptosis by perturbing redox homeostasis in gastric cancer cells in vitro and in vivo. PMID: 26890145 Ref: Helicobacter pylori Activates IL-6-STAT3 Signaling in Human Gastric Cancer Cells: Potential Roles for Reactive Oxygen Species. PMID: 26910614 Ref: Prognostic role of STAT3 in solid tumors: a systematic review and meta-analysis. PMID: 26959884 Ref: Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression. PMID: 26974160 Ref: Expression of p-STAT3 and vascular endothelial growth factor in MNNG-induced precancerous lesions and gastric tumors in rats. PMID: 26989466 Ref: Associations of potentially functional variants in IL-6, JAKs and STAT3 with gastric cancer risk in an eastern Chinese population. PMID: 27049718 Ref: Targeting HCCR expression resensitizes gastric cancer cells to chemotherapy via down-regulating the activation of STAT3. PMID: 27052330 Ref: Piperlongumine inhibits gastric cancer cells via suppression of the JAK1,2/STAT3 signaling pathway. PMID: 27053336 Ref: Salinomycin exerts anti-angiogenic and anti-tumorigenic activities by inhibiting vascular endothelial growth factor receptor 2-mediated angiogenesis. PMID: 27058891 Ref: Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis. PMID: 27109105 Ref: Knockdown of CMTM3 promotes metastasis of gastric cancer via the STAT3/Twist1/EMT signaling pathway. PMID: 27121055 Ref: Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro. PMID: 27122665 Ref: The Functional SOCS3 RS115785973 Variant Regulated by MiR-4308 Promotes Gastric Cancer Development in Chinese Population. PMID: 27160093 Ref: Mitochondrial GRIM-19 as a potential therapeutic target for STAT3-dependent carcinogenesis of gastric cancer. PMID: 27167343 Ref: Role of the IL-11/STAT3 signaling pathway in human chronic atrophic gastritis and gastric cancer. PMID: 27173233 Ref: Recent updates of precision therapy for gastric cancer: Towards optimal tailored management. PMID: 27217696 Ref: Protein arginine methyltransferase 5 is associated with malignant phenotype and peritoneal metastasis in gastric cancer. PMID: 27315569 Ref: Novel STAT 3 inhibitors for treating gastric cancer. PMID: 27322026 Ref: Type II cGMPdependent protein kinase inhibits EGFinduced JAK/STAT signaling in gastric cancer cells. PMID: 27357186 Ref: Isoproterenol regulates CD44 expression in gastric cancer cells through STAT3/MicroRNA373 cascade. PMID: 27512943 Ref: MiR-148a Functions as a Tumor Suppressor by Targeting CCK-BR via Inactivating STAT3 and Akt in Human Gastric Cancer. PMID: 27518872 Ref: Epigenetic silencing of the NR4A3 tumor suppressor, by aberrant JAK/STAT signaling, predicts prognosis in gastric cancer. PMID: 27528092 Ref: Aberrant JAK/STAT Signaling Suppresses TFF1 and TFF2 through Epigenetic Silencing of GATA6 in Gastric Cancer. PMID: 27598141 Ref: Novel long non-coding RNA GACAT3 promotes gastric cancer cell proliferation through the IL-6/STAT3 signaling pathway. PMID: 27644247 Ref: Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs. PMID: 27671820 Ref: Advances in Systemic Therapy for Metastatic or Advanced Gastric Cancer. PMID: 27697983 Ref: Anticancer effect of cucurbitacin B on MKN-45 cells via inhibition of the JAK2/STAT3 signaling pathway. PMID: 27698776 Ref: Astragalus extract inhibits proliferation but enhances apoptosis in gastric cancer. PMID: 27731799 Ref: Berberine inhibits EGFR signaling and enhances the antitumor effects of EGFR inhibitors in gastric cancer. PMID: 27738318 Ref: miR-590-5p regulates gastric cancer cell growth and chemosensitivity through RECK and the AKT/ERK pathway. PMID: 27757042 Ref: Sulforaphane improves chemotherapy efficacy by targeting cancer stem cell-like properties via the miR-124/IL-6R/STAT3 axis. PMID: 27824145 Ref: STAT3 signaling drives EZH2 transcriptional activation and mediates poor prognosis in gastric cancer. PMID: 27938379 |
Ref: The promotion of the transformation of quiescent gastric cancer stem cells by IL-17 and the underlying mechanisms. PMID: 27524415 Ref: CMTM3 decreases EGFR expression and EGF-mediated tumorigenicity by promoting Rab5 activity in gastric cancer. PMID: 27867015 Ref: Gastric Cancer Cell Proliferation and Survival Is Enabled by a Cyclophilin B/STAT3/miR-520d-5p Signaling Feedback Loop. PMID: 28011625 Ref: A novel synthetic Asiatic acid derivative induces apoptosis and inhibits proliferation and mobility of gastric cancer cells by suppressing STAT3 signaling pathway. PMID: 28053540 Ref: Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation. PMID: 28061458 Ref: Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients. PMID: 28061480 Ref: IL-17B activated mesenchymal stem cells enhance proliferation and migration of gastric cancer cells. PMID: 28145881 Ref: Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling. PMID: 28160627 Ref: Generation of an inducible mouse model to reversibly silence Stat3. PMID: 28170160 Ref: Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1. PMID: 28182003 Ref: New agents on the horizon in gastric cancer. PMID: 28184417 Ref: IL-6 secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and metastasis of gastric cancer via JAK2/STAT3 signaling pathway. PMID: 28186964 Ref: Cryptotanshinone potentiates the antitumor effects of doxorubicin on gastric cancer cells via inhibition of STAT3 activity. PMID: 28222632 Ref: IGF1/IGF1R/STAT3 signaling-inducible IFITM2 promotes gastric cancer growth and metastasis. PMID: 28223169 Ref: Resistance Mechanism against Trastuzumab in HER2-Positive Cancer Cells and Its Negation by Src Inhibition. PMID: 28223426 Ref: Proapoptotic and Growth-inhibitory Effects of Plumbagin on Human Gastric Cancer Cells Via Suppression of Signal Transducer and Activator of Transcription 3 and Protein Kinase B. PMID: 28236621 Ref: Basic Transcription Factor 3 Is Required for Proliferation and Epithelial-Mesenchymal Transition via Regulation of FOXM1 and JAK2/STAT3 Signaling in Gastric Cancer. PMID: 28276310 Ref: Integrated expression analysis identifies transcription networks in mouse and human gastric neoplasia. PMID: 28281307 Ref: GKN2 increases apoptosis, reduces the proliferation and invasion ability of gastric cancer cells through down-regulating the JAK/STAT signaling pathway. PMID: 28337309 Ref: REG3A promotes the proliferation, migration, and invasion of gastric cancer cells. PMID: 28435292 Ref: Low-dose paclitaxel suppresses the induction of M2 macrophages in gastric cancer. PMID: 28440494 Ref: Regulation of Gastric Metaplasia, Dysplasia, and Neoplasia by Bone Morphogenetic Protein Signaling. PMID: 28462376 Ref: Correction: miR-874 functions as a tumor suppressor by inhibiting angiogenesis through STAT3/VEGF-A pathway in gastric cancer. PMID: 28468128 Ref: Knockdown of long non-coding RNA HOXD-AS1 inhibits gastric cancer cell growth via inactivating the JAK2/STAT3 pathway. PMID: 28475004 Ref: A positive crosstalk between CXCR4 and CXCR2 promotes gastric cancer metastasis. PMID: 28481874 Ref: Regulation of CD44v6 expression in gastric carcinoma by the IL-6/STAT3 signaling pathway and its clinical significance. PMID: 28507278 Ref: Troxerutin (TXN) potentiated 5-Fluorouracil (5-Fu) treatment of human gastric cancer through suppressing STAT3/NF-kappaB and Bcl-2 signaling pathways. PMID: 28531805 Ref: SIRT6 inhibits growth of gastric cancer by inhibiting JAK2/STAT3 pathway. PMID: 28656307 Ref: Correlation Between Thrombospondin-1 Expression in Non-cancer Tissue and Gastric Carcinogenesis. PMID: 28668845 Ref: Increased tumor-infiltrating CD45RA(-)CCR7(-) regulatory T-cell subset with immunosuppressive properties foster gastric cancer progress. PMID: 28817117 Ref: Interleukin 6 induces M2 macrophage differentiation by STAT3 activation that correlates with gastric cancer progression. PMID: 28828629 Ref: Tumor-Associated Macrophages Promote Epigenetic Silencing of Gelsolin through DNA Methyltransferase 1 in Gastric Cancer Cells. PMID: 28835422 Ref: miR-93-5p/IFNAR1 axis promotes gastric cancer metastasis through activating the STAT3 signaling pathway. PMID: 28842285 Ref: Anti-tumor bioactivities of curcumin on mice loaded with gastric carcinoma. PMID: 28848967 Ref: Downregulation of Piwil3 suppresses cell proliferation, migration and invasion in gastric cancer. PMID: 28869440 Ref: B7-H3 promotes gastric cancer cell migration and invasion. PMID: 29069741 Ref: CDX2 is involved in microRNA-associated inflammatory carcinogenesis in gastric cancer. PMID: 29113265 Ref: RNAi-mediated silencing of NOX4 inhibited the invasion of gastric cancer cells through JAK2/STAT3 signaling. PMID: 29118906 Ref: CD163 as a novel target gene of STAT3 is a potential therapeutic target for gastric cancer. PMID: 29152078 Ref: Novel allylated monocarbonyl analogs of curcumin induce mitotic arrest and apoptosis by reactive oxygen species-mediated endoplasmic reticulum stress and inhibition of STAT3. PMID: 29254150 Ref: Sorcin induces gastric cancer cell migration and invasion contributing to STAT3 activation. PMID: 29262638 Ref: Constitutive activation of STAT3 and cyclin D1 overexpression contribute to proliferation, migration and invasion in gastric cancer cells. PMID: 29312519 Ref: GRAM domain-containing protein 1B (GRAMD1B), a novel component of the JAK/STAT signaling pathway, functions in gastric carcinogenesis. PMID: 29383166 Ref: Cryptotanshinone induces ROS-mediated apoptosis in human gastric cancer cells. PMID: 29383168 |
Ref: Src promotes EGF-induced epithelial-to-mesenchymal transition and migration in gastric cancer cells by upregulating ZEB1 and ZEB2 through AKT. PMID: 29052277 Ref: Enhanced gastric cancer growth potential of mesenchymal stem cells derived from gastric cancer tissues educated by CD4(+) T cells. PMID: 29057538 Ref: Effects of purified Omphalia lapidescens protein on metastasis, cell cycle, apoptosis and the JAK-STAT signaling pathway in SGC-7901 human gastric cells. PMID: 29102525 Ref: Inhibition of two gastric cancer cell lines induced by fucoxanthin involves downregulation of Mcl-1 and STAT3. PMID: 29110251 Ref: STAT3-induced lncRNA HAGLROS overexpression contributes to the malignant progression of gastric cancer cells via mTOR signal-mediated inhibition of autophagy. PMID: 29329543 Ref: Clinical Utility of a STAT3-Regulated miRNA-200 Family Signature with Prognostic Potential in Early Gastric Cancer. PMID: 29330205 Ref: Long noncoding RNA NEAT1-modualted miR-506 regulates gastric cancer development through targeting STAT3. PMID: 29363783 Ref: Hyperactive gp130/STAT3-driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development. PMID: 29417587 Ref: Increased expression of hepcidin and associated upregulation of JAK/STAT3 signaling in human gastric cancer. PMID: 29434930 Ref: Parthenolide facilitates apoptosis and reverses drug-resistance of human gastric carcinoma cells by inhibiting the STAT3 signaling pathway. PMID: 29467878 Ref: Effects of purified Omphalia lapidescens protein on metastasis, cell cycle, apoptosis and the JAK-STAT signaling pathway in SGC-7901 human gastric cells. PMID: 29541181 Ref: Highly Expressed Granulocyte Colony-Stimulating Factor (G-CSF) and Granulocyte Colony-Stimulating Factor Receptor (G-CSFR) in Human Gastric Cancer Leads to Poor Survival. PMID: 29567938 Ref: Interleukin-23 promotes the migration and invasion of gastric cancer cells by inducing epithelial-to-mesenchymal transition via the STAT3 pathway. PMID: 29574157 Ref: Novel long noncoding RNA GACAT3 promotes colorectal cancer cell proliferation, invasion, and migration through miR-149. PMID: 29593420 Ref: PGD2/PTGDR2 Signaling Restricts the Self-Renewal and Tumorigenesis of Gastric Cancer. PMID: 29604141 Ref: High density of CD68+ tumor-associated macrophages predicts a poor prognosis in gastric cancer mediated by IL-6 expression. PMID: 29616104 Ref: MiR-340 affects gastric cancer cell proliferation, cycle, and apoptosis through regulating SOCS3/JAK-STAT signaling pathway. PMID: 29658372 Ref: Cancer-Associated-Fibroblasts Promote the Chemo-Resistance in Gastric Cancer through Secreting IL-11 targeting JAK/STAT3/Bcl2 Pathway. PMID: 29690750 Ref: CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer. PMID: 29690901 Ref: LncRNA PVT1 promotes angiogenesis via activating the STAT3/VEGFA axis in gastric cancer. PMID: 29706652 Ref: Cancer-associated fibroblasts-stimulated interleukin-11 promotes metastasis of gastric cancer cells mediated by upregulation of MUC1. PMID: 29709516 Ref: Upregulation of bone morphogenetic protein 1 is associated with poor prognosis of late-stage gastric Cancer patients. PMID: 29720137 Ref: IGF-1-induced MMP-11 expression promotes the proliferation and invasion of gastric cancer cells through the JAK1/STAT3 signaling pathway. PMID: 29731870 Ref: miR-337-3p suppresses the proliferation and invasion of hepatocellular carcinoma cells through targeting JAK2. PMID: 29736311 Ref: Knockdown of TMEM45B inhibits cell proliferation and invasion in gastric cancer. PMID: 29803169 Ref: Inhibitory effects of isocryptotanshinone on gastric cancer. PMID: 29915371 Ref: EGFL7: Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis. PMID: 29923200 Ref: Induction of Pro-Inflammatory Response via Activated Macrophage-Mediated NF-kappaB and STAT3 Pathways in Gastric Cancer Cells. PMID: 29929193 Ref: Influence of single nucleotide polymorphisms in pri-miR-124-1 and STAT3 genes on gastric cancer susceptibility. PMID: 29938592 Ref: Human epidermal growth factor receptor 2 expressions and Janus-activated kinase/signal transducer and activator of transcription 3-suppressor of cytokine signaling 3 pathway may be associated with clinicopathological features and prognosis of gastric canc PMID: 29970682 Ref: Correction: Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1. PMID: 30013076 Ref: Pachymic acid inhibits growth and induces cell cycle arrest and apoptosis in gastric cancer SGC-7901 cells. PMID: 30013646 Ref: NFIB promotes cell growth, aggressiveness, metastasis and EMT of gastric cancer through the Akt/Stat3 signaling pathway. PMID: 30015981 Ref: Discovery of an Indirubin Derivative as a Novel c-Met Kinase Inhibitor with in vitro Anti-Tumor Effects. PMID: 30060294 Ref: EphA3 contributes to tumor growth and angiogenesis in human gastric cancer cells. PMID: 30066881 Ref: LncRNA GACAT3 acts as a competing endogenous RNA of HMGA1 and alleviates cucurbitacin B-induced apoptosis of gastric cancer cells. PMID: 30098426 Ref: Oxymatrine exhibits anti-tumor activity in gastric cancer through inhibition of IL-21R-mediated JAK2/STAT3 pathway. PMID: 30103640 Ref: Ceramide synthase 6 predicts the prognosis of human gastric cancer: It functions as an oncoprotein by dysregulating the SOCS2/JAK2/STAT3 pathway. PMID: 30129684 Ref: HGF-mediated crosstalk between cancer-associated fibroblasts and MET-unamplified gastric cancer cells activates coordinated tumorigenesis and metastasis. PMID: 30158543 Ref: GACAT3 promoted proliferation of osteoarthritis synoviocytes by IL-6/STAT3 signaling pathway. PMID: 30178830 Ref: Gastric cancer mesenchymal stem cells derived IL-8 induces PD-L1 expression in gastric cancer cells via STAT3/mTOR-c-Myc signal axis. PMID: 30206229 Ref: Tanshinone IIA inhibits cell proliferation and tumor growth by downregulating STAT3 in human gastric cancer. PMID: 30214513 Ref: Sorcin a Potential Molecular Target for Cancer Therapy. PMID: 30216763 Ref: Y-box binding protein-1 and STAT3 independently regulate ATP-binding cassette transporters in the chemoresistance of gastric cancer cells. PMID: 30221675 Ref: The compound 2-(naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via reactive oxygen species-regulated mitogen-activated protein kinase, protein kinase B, and signal transducer and activator of transcription 3 signaling in human gast PMID: 30222185 Ref: Regulation of miR-155 affects the invasion and migration of gastric carcinoma cells by modulating the STAT3 signaling pathway. PMID: 30250530 Ref: TMEM119 promotes gastric cancer cell migration and invasion through STAT3 signaling pathway. PMID: 30271166 Ref: S1PR1 predicts patient survival and promotes chemotherapy drug resistance in gastric cancer cells through STAT3 constitutive activation. PMID: 30316864 Ref: Knockdown of RNF6 inhibits gastric cancer cell growth by suppressing STAT3 signaling. PMID: 30323630 Ref: Paeoniflorin Inhibits Migration- and Invasion-Promoting Capacities of Gastric Cancer Associated Fibroblasts. PMID: 30361813 |