Primary Site >> Liver Cancer
Gene >> SREBF2
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Ref: Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. PMID: 21147110 |
Ref: The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation. PMID: 27013235 Ref: SND1 overexpression deregulates cholesterol homeostasis in hepatocellular carcinoma. PMID: 27238764 |
Ref: NS5ABP37 inhibits liver cancer by impeding lipogenesis and cholesterogenesis. PMID: 27862769 Ref: Pro-inflammation NF-kappaB signaling triggers a positive feedback via enhancing cholesterol accumulation in liver cancer cells. PMID: 28100270 |
Ref: Targeting the mevalonate pathway is a novel therapeutic approach to inhibit oncogenic FoxM1 transcription factor in human hepatocellular carcinoma. PMID: 29765517 |